Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.


Protein Function Description

Instruction: Predict the functional description of the protein sequence below.

Output: The glycine cleavage system catalyzes the degradation of glycine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell-wall hydrolase involved in septum cleavage during cell division.


Instruction: Predict the general functional description of the protein sequence.

Input: MHEMSIAMSVVEAVVDKAREEGGGKITGIDLVVGRLAGVEVESLKFCFGAAARGTLAEGAELVIEEPEGRGRCEACGAEFPVTSFYAKCSACGQFRVKIESGRELAVRSFTIE

Output: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.


Instruction: What is the functional description of the protein sequence?

Input: MGLTKEHKTEIITKFGDSATDTGKAEVQVALFTRRITDLTGHLQQHPKDKHSRRGLLMLVGKRKRVLNYLKKVDIERYRKVLADLDLRK

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Predict the functional description of the protein sequence below.

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Predict the functional description of the protein sequence below.

Input: MNKGEDNLVRTSITVPEQLLQKVNELIASGYFASRSEIFRQALREYLQRIEWTERVGDEEYFGALTYVFQHERAEPELVKVQHEFTDVIISTTHIHVSPEKCLEVLLLQGPGKRIAELAKRIRGVRGVEQAKLTVVSSEGE

Output: Transcriptional regulator.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.


Instruction: Predict the general functional description of the protein sequence.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MDKKAIFDSVSNMEEQIGELYQQLGDLKTNLGEMLEENNRLNLENEHLRRRLSLTDEATPEPKAETEAEHGVMAPNRKEAMQQMIELGEGYDNLVQLYKEGFHVCNVHFGSPRGNDEDCLFCLSLLNKK

Output: Involved in initiation control of chromosome replication.


Instruction: Predict the functional description of the protein sequence below.

Input: MELTTRTIAARKHIALVSHDHCKKSLLAWVMENRDLLAQHELYATGTTGNLVQKATGIDVHCLLSGPMGGDQEVGALISEKKIDILIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNRSTADFLIGSTLFSSEVTIAIPDYDRYMQQRLDLK

Output: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


Instruction: What is the functional description of the protein sequence?

Output: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: Predict the functional description of the protein sequence below.

Output: In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation. May be an efflux transporter and involved in maintaining correct cell wall permeability. Probably required with LprG for normal surface localization of lipoarabinomannan (LAM).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May have a role in meiosis and sporulation.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKNDTLNDVINSIKNASRLGKREIIAEPAAKLIGKVLKVMQDYNYIKSFEVIDESRGGKFKIVLNTTINNCGVIKPRFPVKNENLEKYEARYLPAEDFGILILTTTKGVMSNIEARKLGIGGKLLAYVY

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MSNQDSGNPAAKPPKGKTAARRKARSLAVQALYSWQIAGQPLHEIEAQFRTDNDFSEVDGAYFHEILHGVPRQKSELDSTFEPCLDRPLAEIDPVELAILRLSTYELRNRIDVPYKVVINEGIELAKTFGATDGHKFVNGVLDKLAPRLRAAELRGGKR

Output: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Transcriptional activator of the nitrous-oxide reductase gene NosZ.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTDTPPENEEQHESNVQNENEVEHLQQEIVTLKTELKEKNDKYLMALAESENSRKRLQKERQELMQYALENTLIDFLNPIESMEKALGFATQMSDDVKNWALGFNMILNQFKQIFEEKGIIEYSSIGQKFNPFLHEAVQTEETSEVPEGTILEEFAKGYKIGERPIRVAKVKVAKAPTPKENKE

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Oxidoreductase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) . SQS1 is composed of a 2,8-dioxobicyclic[3.2.1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms . These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase clz14, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product . The phenylalanine ammonia lyase (PAL) clz10 and the acyl-CoA ligase clz12 are involved in transforming phenylalanine into benzoyl-CoA . The citrate synthase-like protein clz17 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit . The potential hydrolytic enzymes, clz11 and clz13, are in close proximity to pks2 and may participate in product release . On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase clz2 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase clz6 (By similarity). The biosynthesis of the tetraketide must involve 3 rounds of chain extension (By similarity). After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (By similarity). The enoyl reductase and C-MeT of clz2 are not active in the final round of extension (By similarity). The acetyltransferase clz6 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (By similarity). The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases clz3, clz15 and clz16 (Probable). Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) clz20, suggesting a likely mechanism for self-resistance (Probable).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: What is the functional description of the protein sequence?

Input: MAKKIDAYIKLQVKSGSANPSPPVGPALGQKGVNIMEFCKAFNARTEKMEKGMPIPVVITVYSDRSFTFETKTPPASYLLKTAAGLKSGSPRPNTQKVGTIARAKIQEIAELKAADMTGADVEAMTRSIEGTARSMGLVVEG

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: Predict the functional description of the protein sequence below.

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MALTAEQKKEILGTYGLHDTDTGSPEAQVALLTKRIADLTEHLKVHKHDHHSRRGLLLLVGRRRRLLKYVAQIDVERYRSLVERLGLRR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKFSQRTLLKLKNKNKKLRPNKYKKLKRETLRGRIKGTVERPRLSVYRSNENIYAQIIDDTNSKTLISCSTLDRSIKLVISTGRTCDASRLMGEKLAKLSLKKNITKIVFDRGPYLYHGRIKAVADGARAGGLQF

Output: Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKKITGYIKLQVPAGKANPAPPIGPALGQHGVNIMEFCKAFNAKTQADEGTITPVVITVYADRSFTFITKTPPVPVLIKKAAGIASGSAVPNKTKVGKLTKAQVEEIAKTKMPDLNAASLEAAMRTVEGTARSMGVDIV

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: What is the functional description of the protein sequence?

Input: MSNQNIRIKLKAFDHRLIDKSALEIVETAKRTGASVRGPIPLPTKKERFTVLTSPHVNKKARDQYELRTYVRLMDVISPTDKTVDALMKLDLAAGVDVAIKLN

Output: Involved in the binding of tRNA to the ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MDQEPIPSSLEDNPQFKEETSLQKFRRRFKEEPLIPLGCAATSYALYRAYRSMKAGDSVEMNKMFRARIYAQFFTLIAVVAGGMYFKTERQQRREFEKMVEQRKAQEKRDAWLRELEVRDKEDKDWRERHAAMEAAAKEAGKRKSVPEQDAARSAIEPADEKSIGVLAAVRELLARQN

Output: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).


Instruction: Predict the functional description of the protein sequence below.

Output: Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MATTNDIKNGTVLKLEGQLWNIIEFQHVKPGKGGAFVRTKMRNVMSGKVVDKTFNAGLKIETATVDRRDYQYLYQDGEDFVFMDTQDYDQITVSGATVGDATNFMLENQMVNIAIHEGTPLYIELPPSVVLEITYTEPGLQGDRSSAGTKPATVETGYEIQVPLFVEQGTKVKVDTRDGSYLGRVND

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLDGKKSLAERIVYGALEQAREKTGTDPVVTLKRAMDNVKPSLEVRSRRVGGATYQVPVEVRPDRSVTLALRWLVSFSKARREKTMVERLANEILDASNGLGAAVKRREDTHKMAEANRAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the guanosine in position 1516 of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSGKNNIISQLEAEQMTKEIPAFAPGDTVVVQVRVTEGNRERLQAFEGVVIGKRNRGMNSSFTVRKISYGVGVERTFQTYSKLIDSVSVKRRGDVRQAKLYYLRDLSGKAARIKEKLN

Output: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


Instruction: Predict the general functional description of the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAIADNKKARFNYTIEEQFEAGMVLEGWEVKAIRAGQVQLTDGYVVVKDGELFLIGCRINPLRTASTHVHPQADRTKKLLMKKDEIRRLVGKVEQKGYTLVPLNLHYKGGRVKADIALAKGKDLHDKRETEKKRDWEREKGQLMRHKISSPRKDT

Output: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.


Instruction: Predict the functional description of the protein sequence below.

Input: MVNDTVANMITSIRNANVIEATTVRIPATNTTKDVGKILLQEGFITNLREHKENTRSFLILTLKYRGRKKKPYITNLKRISKPGLRIYSNHREIPKVLGGMGIVILSTSSGIVTDREARQKQIGGEILCYVW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: May bind RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Acts as a chaperone.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKPSDWLILQKKVRFGDCDSAGVIHFHNLLKWSHEAWEESIEIYGIPCNDIFPDFSIRKSQIIFPIVNCEANFNAPIKIGDLLKVKIAPHKINTHLFQVNSFFIKNGNKVAEGKIIHCSLDVDSRNKIEIPDQLERWIEASNVSTNLKEC

Output: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the desulfonation and deamination of L-cysteate, yielding pyruvate, sulphite and ammonium. Involved in sulfolactate degradation.


Instruction: Predict the general functional description of the protein sequence.

Input: MSGASARDATFLAFDYGEKRIGVALGNALTRSARALVVIPNLNREHRFKAVGELLAEWRPDALVVGLPMHPDGTPHDMTQQAKRFGNQLNGRFGLPVTWVDERYSSVEAEAGLRERNVRGRARTDMLDAEAARVILQQYFDELSDHEHH

Output: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).


Instruction: Predict the functional description of the protein sequence below.

Output: Molecular chaperone. Has ATPase activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


Instruction: Predict the functional description of the protein sequence below.

Input: MSRIGRKSIPVPTGVDVTIAGQTVTVKGPKGELSHTIAEPITIDRAEDGQLNVARPNDERKAKELHGLSRTLVANMIVGVTEGYRKSLEIAGTGYRVTAKGKDLEFALGFSHPVTVVAPEGITFSVEKPTLFHVAGINKQLVGEVAANIRKIRPPEPYKGKGVKYQGEVIRRKAGKAGKK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MARIAGVDLPREKRIEIALTYIFGIGLSRSKQILRDTGVDPNKRVKDLTDDEVAKIRDYIDKNFKVEGELRAEIARNIKRLIDIRCYRGLRHLRGLPVRGQRTRTNARTRKGPRKTVGVMRKKS

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPVLVSNLQGKVAVDEALTGLLTRAAQEVLKAEGYGEEAEVSLVFVDDAYIHGLNRQYRGVDAPTDVLSFAMQEGEPLAGGEEELILGDVVISLQAAERQAGEYGHSLQREAAYLAVHGVLHLLGYDHQGEEERKIMRRKEEEVLGRLNLTR

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


Instruction: Predict the functional description of the protein sequence below.

Input: MSRIGKSPIPIPDKVSVSLDGLAVTVKGPKGELKRTLPDGVTVNQVDNTIVVAPTSEKRQSRERHGLCRTLVANMIEGVSKGYSKKLEIVGVGSRAQVKGKTLVVSAGYSHPVEMLAPEGITFAVENNTNVTVSGTDKELVGNEAAKIRAIRPPEPYKGKGIKYAGERILRKAGKSGKK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKRVQVVLSEDILSLGKDGDLVEVAPGYARNFLLPHGKALPVTPAVLKQVEHRRAKEAERLAALKADAVAFRTALDTIGRFTVKKQTGGDDVLFGTVTNVDVAEAIESATKKLVDKRDITVPEVHRTGNYKVQVKLHPEVVAEINLEVVSH

Output: Binds to the 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MEQQHIEVVGKLGSTYGIRGWLRIYSSTEQAESIFDYQPWFLKIKGEWQSIELENWRYHNHEIIVKLKGVDDREAAQILANVEIGVDLSVFPELEEGDYYWHDLIGCTVVNLEGYTMGTVTEMMETGSNDVLVVKANTKDAFGKQERLIPFLYEQVVKRVDLTTKTIEVDWDAGF

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.


Instruction: Predict the functional description of the protein sequence below.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


Instruction: Predict the functional description of the protein sequence below.

Input: MSRVGRLPIAIPADVTVTVTPDNLVTVKGPKGELVKTMHKDISIAVENNEVIVTRHSEQKDHRALHGLTRALINNMVIGVKQGYQKTLDLVGVGYRAQLQGKKLVMNLGYSHPVEIEPIDGITFETPAATRVIVSGIDKEKVGFAAADIRKWRVPEPYKGKGIKYENEVIRRKEGKTGKK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: What is the functional description of the protein sequence?

Input: MDIISLGWSSLLVVFTFSLSLVVWGRNGF

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: What is the functional description of the protein sequence?

Input: MAEKKRAQEQEKVQEDQKMQNEQNECEEVEKKLQECEEKYLRVHADFENTKKRLEREKIQAIEYSLEKFAQDLLPALDSLDMALAAVSHDNLNAEEAVKELKKGIELTIDQFIKAFNKNGIEVIEIEEGGEFNPHLHEAILQVDDAEKKAGQIVQVIQKGYKYKERILRPAKVSVAKGNE

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSVTAERKAQIIKEFATAEGDTGSPEVQVAILTERINNLTEHFKDHKKDNHSRRGLLALVSSRRSLLDYLKKKDEARYTKLIGALGIRR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Predict the general functional description of the protein sequence.

Input: MFAVIKTGGKQYRVAANDLIKVEKVAGEAGDIVEFAEVLMVGSTIGAPTVAGAIVTAEVVEQGRARKVIAFKKRRRQNSKRTRGHRQELTTIRISEILTDGAKPSKKAAEKKAPKAAPKKAAAKAESAE

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: Predict the functional description of the protein sequence below.

Input: MARVKTGVVRRRKHKKVLKLARGFYSGRRKHFRKAKEQLERSLVYAYRDRRRKKTDFRRLWIVRINAACRLNDLSYSRFINGLKKAGIELDRKILADLAMNDVAAFAKIAEAAKKAL

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Splits dipeptides with a prolyl residue in the C-terminal position.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in DNA repair and RecF pathway recombination.


Instruction: What is the functional description of the protein sequence?

Input: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG

Output: This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.


Instruction: Predict the functional description of the protein sequence below.

Output: Provides the (R)-glutamate required for cell wall biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Input: MDVTRLLLATLLVFLCFFTACSHPPPGEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Output: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSRIDQSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNGHVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNVLLKPASEGTGVIAGGPVRAVLELAGLADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKSVEDLLG

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the general functional description of the protein sequence.

Output: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.


Instruction: What is the functional description of the protein sequence?

Output: Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MEAIFELLGYQYKASLNWDIYIPLLKGYNKGKNIFIKKILFIKNNGLIINGFPYINRGIIKAKIIKHIRDKKQICFKSKKRKGFKLKKGHRQYLTKIKIIYIEF

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: Predict the functional description of the protein sequence below.

Output: Provides the (R)-glutamate required for cell wall biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Input: MPLLLSGKEFRDDLESACCLAIQTPLEGGAETRLLRRLKAAGYRTQITSVRGFGDPEVFLLKLHGIRPPHLGHQNIGRNGALGEVQEVIPQLHELLSEEQPLALWLLEGQVLSRSELLALCDLSEKDPQLKIVVEMGGERKLKWQSMRKFLEQ

Output: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Acts as a chaperone.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).


Instruction: What is the functional description of the protein sequence?

Input: MMTPTIPVALFDRLLVEGISPHELVRRKLMCLFNSCAVPGGETLPPLLTRGMPEWHEVNVGDKRVLNWFCRELRAAILRYEPSINMLKVSVKDAHHQTLALSLEAMLQDESEPLRLEIAYSNGRWR

Output: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.


Instruction: What is the functional description of the protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


Instruction: What is the functional description of the protein sequence?

Output: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).


Instruction: What is the functional description of the protein sequence?

Output: Involved in DNA repair and RecF pathway recombination.


Instruction: What is the functional description of the protein sequence?

Input: MAKVSSIKKNESRKKKSQSLHNKRLALKSKIYDKNISLEERFSLVMSLAQLPRNSSSTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGLVPGVVKSSW

Output: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.


Instruction: Predict the functional description of the protein sequence below.

Input: MAVKERVGVVVSDKMDKTVVVAIENRSPHPKYGKIVVKTQKFKAHDAENQAKQGDRVRIRETRPLSKTKRWEVAEILTDS

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: What is the functional description of the protein sequence?

Output: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKTDIHPKYVAAKIKCACGTVIETRSTSGDISVEICSNCHPFFTGKSKLVDTTGRVDKFKKKYKMK

Output: Binds the 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the guanosine in position 1516 of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MANIKSAKKRAVQSEKRRKHNASRRSMVRTFIKKVYAAIAAGDKDAAQKAFNEMQPIVDRQSCKGLIHKNKAARHKSNLVAQINAMQ

Output: Binds directly to 16S ribosomal RNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.


Instruction: Predict the functional description of the protein sequence below.

Output: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQCPYCQHTNSRVLESRSSEGGQSIRRRRECLNCKHRFTTYERIEFVPITVIKHDGKKESFDASKLLRGMVRACEKTGISHQRLETIVDDIEAYLQQRPQREVTTHEIGQLVLKYLREENEVAYIRFASVYGRFKGIKDFVETLDQLQEETISSPMSQWSKSSTRDRDQSQTSPCLSLTHNGSENSR

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAKRKQNVRSKRKVKKNIESGIVHIRSTFNNTIVTITDMQGNAISWATAGNMGFKGSRKSTPFAAQLASETAAKTAMDNGMRTVEVNVKGPGAGREAAIRALQAIGLEVTAIRDVTPVPHNGCRPPKRRRV

Output: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.


Instruction: Predict the functional description of the protein sequence below.

Output: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the functional description of the protein sequence below.

Input: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.


Instruction: Predict the functional description of the protein sequence below.

Input: MIIERLIGNLRDLNPLDFSVDYVDLEWFETRKKIARFKTRQGKDIAIRLKDAPKLGLSQGDILFKEEKEIIAVNILDSEVIHIQAKSVAEVAKICYEIGNRHAALYYGESQFEFKTPFEKPTLALLEKLGVQNHVLSSKLDSKDRLTVSMPHSEPNFKVSLASDFKVVMK

Output: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.


Instruction: What is the functional description of the protein sequence?

Input: MSSKEQNTPNEQASDEIETEQAKNQGADTAAEAADQRDERIAQLEAQLAESQGGVRDAQLRAQAEIENIRRRAELDVEKAHKFALEKFSNELLPVIDSLERALEVADKSNPELAAMIEGIDLTMKSLLGAVRKFGVEVVGDTNVPFNPEVHQAMSMMESEEVEPNHVMMVMQRGYTLNGRLLRPAMVAVAKSKG

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.


Instruction: What is the functional description of the protein sequence?

Input: MPKKTQQSVSFEASLQQLEQIVSRLESGDLALEEALNEFERGVQLARAGQQVLQQAEQRVQILLSDDKNAELTPFTPEKE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKNVTDSFVSLGHWRSAGSFGFNTDIFATNPINLSVVIGVLIFFGKGVFSDLLDNRKLRIVNTIRNSEELCGRAVEQLEKARARLRKVEMEADQFRMNGYSEIERDKLNLINSIYKTLEQLENYKNETIHFEQQRVINQVRLRVFQQALQGALGTLNSCLSNELHLRTINANIGMFGAMKEITD

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MANHKSTQKSIRQDQKRNLINKSRKSNVKTFLKRVTLAINAGDKKVASEALSAAHSKLAKAANKGIYKLNTVSRKVSRLSRKIKQLEDKI

Output: Binds directly to 16S ribosomal RNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDIYLYINSPGGVVTAGLAIYDTMNFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARVMIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQPFEKVAADTERDNFMSAVEAMEYGLIDKVLTHRDIK

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MANTPQAKKRARQNEKARKHNASMRSMGRTYLKKVLSAIQTGDQAAAQAAYVSAVAVIDRIADKGLIHKNKAARHKSRLNAKLKAMAA

Output: Binds directly to 16S ribosomal RNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAARLQEFYKEQVVPKLIEQFGYKSVMEVPRITKITLNMGLGEAINDKKIIENAVGDLTKIAGQKPVVTKAKKAIAGFKIRQGYPIGAMVTLRGERMFEFLDRFVTVALPRVRDFRGVSGRSFDGRGNYNIGVKEQIIFPEIEYDKIDALRGLNISITTTAKNDEEAKALLGAFKFPFRN

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Input: MLSNILPLSIGAIFGTTARWLLNLAVPASLSPATGNLFANWTGALLIGIFAETVSHPQWKLLLITGFFGSLTTLSGFSLETVTLLQSNRPASALANIFLHTAGSLLLTWLGLKIGTAVK

Output: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.


Instruction: Predict the functional description of the protein sequence below.

Input: MALTKAEMAEKLFDEVGLNKREAKEFVDAFFDVLREALEQGRQVKLSGFGNFDLRRKNQRPGRNPKTGEEIPISARTVVTFRPGQKLKERVEAYAGSGQ

Output: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.


Instruction: Predict the general functional description of the protein sequence.

Input: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGNPFELEADGLLAICIQHEMDHLVGKLFIDYLSPLKQQRIRQKVEKLDRLNARA

Output: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: Predict the functional description of the protein sequence below.

Input: METATLIAISISGLIVSFTGYALYTAFGQPSQQLRDPFEEHGD

Output: May play a role in photosystem I and II biogenesis.


Instruction: Can you provide the functional description of the following protein sequence?

Input: METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR

Output: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).;


Instruction: Predict the functional description of the protein sequence below.

Output: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.


Instruction: Predict the functional description of the protein sequence below.

Input: MSDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQTGETLLIIADDPATTRDIPGFCTFMEHDLLAQETEGLPYRYLLRKAH

Output: Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKKIAAQFRLLLPAGKATPAPPVGPALGQRGVNIMEFIKRFNAATASMGDVLVPVDVTVFADKSFTFEVRTPPASFLLKKAAKVEKGSGEPNKVTVGKVTRAQVEEIAKQKMKDLNTEDLEAAVRIIEGTARSMGIQVVD

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: Predict the functional description of the protein sequence below.

Input: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLAAAVNELENCIATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPADHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALWQWLPEFVVRCRQYDSFGFYAALSQLLLVLVESDHQNR

Output: Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.


Instruction: Predict the general functional description of the protein sequence.

Input: MALNLEQKKAMVAEITDIANQAVSAVAADYRGLTVSEMSDLRKSAREARVHMRVYRNTLARRAFKETTYACLEEVLTGPIVLFFSQEEPGAAARLIEKFIKEHERLEVKGLALGGELLPAEKLKAVARLPSREEALSQLAAVLLAPVTKLVRTLNEPIAQVARVMAAVRDQKAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Input: MQQGIHPDYHPVEVTCSCGNTFVTRTAGKEDHMFVDVCSQCHPFYTGKQKILDTGGRVARFEKRYGKKSK

Output: Binds the 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Shows a 3'-5' exoribonuclease activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.


Instruction: Predict the general functional description of the protein sequence.

Input: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Predict the functional description of the protein sequence below.

Output: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.


Instruction: Predict the functional description of the protein sequence below.

Input: MRTSHMLEHLMEALRCLPGVGPKSAQRMAFHLLQRDRKGGLQLAEALSQAMTEIGHCNECRTFTEEETCHICTNPKRQDNGQICVVESPADIAAIEATGQYSGRYFVLMGHLSPLDGIGPSDIGLDVLDYRLRRGDITEVILATNPTVEGEATAHYIAELCNAHEVNASRIAHGVPVGGELELVDGTTLSHSLLGRHKI

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: What is the functional description of the protein sequence?

Output: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPRRRIIGTRKILPDPKFSSELLAKFINILMIDGKKSIAEVIVYTALKNLSKRTDKKELEAFEIALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVESARKRVDKSMSLRLSNELYDALENKGTAVKKREEVHRMAEANKAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MAEIILNVEVRDGAGTGNARATRRAGKVPGVLYGGGKAPVNIAVKANEFRKSLYTGKLLGHLVTLQYGEEKQSVIAKAVQFHPVTDEPVHFDLYRVDEHQLIKIEVPVHFKNHETSVGLKKGGTLEVIRHTVELACPADKIPEELVIDLAGHDIGDVIRISEVKLPEGVKPAMDRDFVIANVKASSAAQSDAGDTTA

Output: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.


Instruction: What is the functional description of the protein sequence?

Input: MARLAGVDIPREKRLEIALTYIYGVGKTRAHETLAATGISADVRVKDLTDAQLVELRDYIEGNYKVEGDLRREVAADIRRKVEIGSYEGLRHRKGLPVRGQRTKTNARTRKGPKRTVAGKKKAR

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: Predict the general functional description of the protein sequence.

Input: MEMLLGTDIIEVDRIKRAIENGGRKFSEKVFTLNEIEYCESRKAGKYQSYAARFAAKEAVSKAFGTGIGKNAAFSEIEILKDSLGKPYVRLSGKAKEFYDSLGTAGISVSLSHCRAYAVAYAVISLGDSFKNKI

Output: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


Instruction: Predict the functional description of the protein sequence below.

Input: MDILKSIENEQIRTDLPKLEIGDFIKVHAKIKEGTRERIQVFEGTVIALKGSGLKETFTVRRISYGVGVERVFPVNSPRVDRIDVVRKGVVRRAKLYYLRDRVGKAAKIKEKLDRK

Output: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


Instruction: What is the functional description of the protein sequence?

Input: MKYSKNESRQRRKIRISKKVSGTAERPRLVVYRSNLHVYAQIVNDLDGATLVATSTLALGKNESGLHCNKGGAEKVGIEIARMAKEKNIDKVVFDRNGYLYHGRVKAVADGAREGGLEF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: Predict the functional description of the protein sequence below.

Input: MARLLLVCLGGALGSGARYLTSAWALRAFGPDFPRGTLLVNVSGSFLLAGIMTASLQSEAVPPDLRLFLAAGVMGGFTTYSSFNYETLALVEQGRLAAAAAYLLATVLGCLAAAFAATLLVRWLAG

Output: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.


Instruction: Predict the general functional description of the protein sequence.

Input: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAAGGAEEATKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANIKEGVAAAEAEEIKAKLEEAGATITLK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MARVKRGVIARRRHKKILKLAKGYYGARSRVFRVAKQAVIKAGQYAYRDRRQRKRQFRALWIARINAGARQNGLSYSRLIAGLKKATIEIDRKVLSDLAVNEKAAFAAIVEKAKAVLA

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Predict the general functional description of the protein sequence.

Input: MEPFRIHKGTAAVLMNDNIDTDQIIPKQYLKRIERTGFGKFLFDEWRYDNNRQENPNFPLNAPDRKGASILITGDNFGCGSSREHAPWALADYGFRVIIAGGFADIFYMNCMKNGMLPIVMDKEMREKLVKTDAREQIEVDLENEVITTSTHRFHFTIEKMWKEKLFNGLDEISITMQYEQEIKEYERRVATY

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


Instruction: Predict the functional description of the protein sequence below.

Input: MTEMKILIVTLTYIEKSIIDEIVNNLSSYGLEVDILFDSRKYLPISAFNWERLQYDAEKVLSFLKSKYDFNYDSIIFLADSDGYIDGYNFVFGLTIDNFAIIFLNRLREEFYNRKPDLELFMKRVVKEVTHEAGHTLGLGHCNTIGCVMNFSNTVEDVDKKQARFCKNCIYKIENLSKYLQRK

Output: Probable zinc metalloprotease whose natural substrate is unknown.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MYCPFCHNEQSRVIDSRVIDSGTSIRRRRECAACKGRFTTIEKAVLSVVKRNGLAEPFSRDKLIRGVKRACQGRDVSDDALKKLAQEVEETVRSHGSSQVNANDIGLAILEPLRDLDEVAYLRFASVYKSFESADDFESEIRLMRRRDRDSF

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).


Instruction: What is the functional description of the protein sequence?

Input: MMRQSLQAVLPEISGNKTSSLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWDNGGWRSATLENVS

Output: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.


Instruction: Predict the functional description of the protein sequence below.

Input: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.


Instruction: Predict the general functional description of the protein sequence.

Output: Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSKVKNIAVVAHDNCKKELLDFVDCNHNILSRHNLVATGTTGGLVEKMIMERVEQKADEGYEFKPVNRMKSGPLGGDQQLGAMISEGKIDVLIFFWDPMQPQPHDVDVKALLRLAVLYNIPTASNRSTAEFLISSPFFEGEFQRKETDFSSYTQRKL

Output: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Releases the N-terminal proline from various substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MRIFVYGSLRTKQGNSHWMTNALLLGEYSIDNYQLYSLGHYPGAVPGNGTVHGEVYRIDNATLAELDALRTRGGEYARQLIQTPYGSAWMYVYQRPVEGLTLIESGNWLDRDQY

Output: May play a role in antibiotic biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Input: GLNRPSKRCLAGSAPCEFHKRSTCCSGHCIIWWCA

Output: Probable neurotoxin with unknown target. Possibly targets ion channels.


Instruction: What is the functional description of the protein sequence?

Input: MKPLHAFPKRWLPWLIGGAFALVAISMMPSLMRHENVVQIRVSHAGAPMPDGFYLYQQLSAQGIRIKSITPSGDALIIHFDNEEQSLAAQKVLRRLLPDGFIVAQHDQAAHLSLA

Output: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.


Instruction: Predict the general functional description of the protein sequence.

Output: Oxidoreductase; part of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable). The hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) nps1 might incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway (By similarity). In addition, the cluster also includes the tryptophan dimethylallyltransferase dma1, the FAD-dependent oxidoreductase toxD, the cytochrome P450 monooxygenase cyp3.1 and the methyltransferase DOTSEDRAFT_139328; the latter 2 being not present in all CPA-producing fungi but involved in additional modifications that occur in biosynthesis of a range of CPA and CPA-like products (Probable). Further studies are required to clarify whether the CPA-like hps1-dma1 cluster is functional or a non-functional relic reflecting evolution of D.septosporum (Probable).


Instruction: What is the functional description of the protein sequence?

Output: Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.


Instruction: Predict the general functional description of the protein sequence.

Input: MTDVAKTLEELCTERGMRMTEQRRVIARILEDSEDHPDVEELYRRSVKVDAKISISTVYRTVKLFEDAGIIARHDFRDGRSRYETVPEEHHDHLIDLKTGTVIEFRSPEIEALQERIAREHGFRLVDHRLELYGVPLKKEDL

Output: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.


Instruction: Can you provide the functional description of the following protein sequence?

Input: NTVSSFQDILMRMSKMQLGSSSEDLNGMITQLESLKLYRDSLGEAVMRMGDLHSLQSRNEKWREQLSQKFEEIRWLIEEVRHRLKNTENSFEQITFMQALQLLLEVEQEIRT

Output: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MKQVNMNRNERRQMRHKRVIKKIRRIDNDRPVMIVVKSNSHISAQVWDFNQNKIIASSSSVSLDLVNGNKENAAVVGTDIANKLLKMKIDEITFDHGGSKYHGRIAALADAARKAGLKF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVTIPPLVSRWFPVCGFRVCKISSPFAFTTPRWPHNDVYIGLPITLLHFPAHFQKFSQPAEISDKRYRVLLCNGHQTPALQQGTHSSRQVTPLSLRSRSSTFNK

Output: Plays a role in modulating host cell signaling by binding to and degrading host RGS16 . Not necessary for virus replication .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: LECKDLGISIDDDNNRRLAVKEGDPLVVQFVNADREGN

Output: Inhibition of trypsin.


Instruction: Predict the general functional description of the protein sequence.

Input: MNMGLFYGSSTCYTEMAAEKIRDIIGPELVTLHNLKDDSPKLMEQYDVLILGIPTWDFGEIQEDWEAVWDQLDDLNLEGKIVALYGLGDQLGYGEWFLDALGMLHDKLSTKGVKFVGYWPTEGYEFTSPKPVIADGQLFVGLALDETNQYDLSDERIQSWCEQILNEMAEHYA

Output: Low-potential electron donor to a number of redox enzymes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in intracellular removal of iron from iron-vibriobactin complex. Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Required for viral crescent formation early during virus morphogenesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MDLRTGEVITAPQAMNGVYTWEINNPLYFTITRHQQRPFLLNQDIITVQVRFNHNLRKELGIHKCFLNFQIWTTLQPQTGLFLRVFRYQVIKYLDNIGVISINNVIRAADHVLFNVIANTIECKLTHEIKFNVY

Output: Increases viral DNA accumulation. Enhances infectivity and symptom expression.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: NEQSGKSQTVIVGSWGAKVS

Output: D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.


Instruction: Predict the general functional description of the protein sequence.

Input: DLTPKVQVYSRFPASAGTKNVLNCFAAGFHPPKISITLMKDGVPMEGAQYSDMSFNDDWSFQRLVYADFTPSSDAVYTCKVDHETLKEPQVYKWDPEF

Output: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.


Instruction: Predict the functional description of the protein sequence below.

Input: MVIETWKKSGIATKFPTYRNSAPVTVHSWQKGKRQDVEAEGLWRIKDGIYDFTEFIDKHPGGTFWIRETKGTDITEAFEAHHLTTAPEKMIAKYKVRDAYQRIYTLTLHEDGFYKTLKERVREKLKTIDKRPKRKSDVSDDL

Output: May play a role in muscle cell metabolism.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKMLTVFDPAMCCSTGVCGSDVDQVLVNFSADVQWLKGRGVQIERYNLAHEPMSFVENEKAKAFLEASGAEGLPLLLLDGETVMAGRYPKRAELARWFGIPLEKVGLASTSCCGGKTSCC

Output: Inducer-independent trans-acting repressor of the ars operon.


Instruction: What is the functional description of the protein sequence?

Output: Required for the formation of sulfated nod factor. Proposed to transfer activated sulfate (PAPS) to a N-acetylglucosamine of the nod factor.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPRKGPVAKRDVLPDPIYNSKLVTRLINKMMVDGKRGKSQAILYSAFDIIAQETGKDPMEVFEQAMKNIMPLLEVKARRVGGANYQVPIEVRADRRSTLGLRWLVNYARLRGEKTMEVRVAREIMDAANNTGASVKKREDTHKMADANRAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPKKNEAPASFETALSELEHIVTRLESGDLPLEDALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEEASPEPFIADNE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: KCCKKGGPRKCPPEGMTXFYERIFRI

Output: Exhibits antibacterial activity. May play a role in protection against parasite settlement.


Instruction: Predict the functional description of the protein sequence below.

Input: GASGLIPVMRN

Output: Mediates visceral muscle contractile activity (myotropic activity).


Instruction: Predict the general functional description of the protein sequence.

Input: RQERLAKLFTEAVRRWDVSFTENLPDYMKELVSFFRKGWEDYLLGYYEEAEWLAAEYVPSLDEYIK

Output: Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MKSNHMQVEAICNGYVIDHIPSGQGVKILRLFSLTDTKQRVTVGFNLPSHDGTTKDLIKVENTEITKSQANQLALLAPNATVNIIENFKVTDKHSLALPKEVENVFPCPNSNCITHGEPVISSFTIKMIKGNIGLKCKYCEKTFSKEIVTAQV

Output: Involved in allosteric regulation of aspartate carbamoyltransferase.


Instruction: What is the functional description of the protein sequence?

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT). Acts as a glycosyltransferase that catalyzes the oligoglycosylation of pre-mycofactocin (PMFT), adding up to nine beta-1,4-linked glucose residues. Is required for the in vivo ethanol assimilation in M.smegmatis.


Instruction: What is the functional description of the protein sequence?

Input: MATTADFKNGLVLVIDGQLWTITEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVDTATVDRRDTTYLYRDGSDFVFMDSQDYEQHPLPEALVGDAARFLLEGMPVQVAFHNGVPLYIELPVTVELEVTHTEPGLQGDRSSAGTKPATLQTGAQINVPLFINTGDKLKVDSRDGSYLGRVNA

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAKDDVIEVDGKVVDTMPNAMFTVELENGHQVLATISGKIRKNYIRILPGDKVQVELSPYDLTRGRITYRFK

Output: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


Instruction: What is the functional description of the protein sequence?

Input: MANRLKEKFVNEITPDLVKKFDYTSVMQVPKIEKIVLNMGVGDAVTNSKNLDEAVAELELISGQKPLVTKAKKSIAGFRLREGMSIGAKVTLRGERMYDFLDKLVNVSLPRVRDFRGVSSKAFDGRGNYTLGVREQLIFPEIDFDNVNRVRGLDIVIVTTANTDEESRELLAQFGMPFEK

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: What is the functional description of the protein sequence?

Input: MSLNRATVAKRYSQALFDLLSEKDQLESGYTELQELRRIFQDNPQLSTMLSDASLQVADREALLQPLLKQASPYIKNLIQMVYDYGRMENMVDIIDQFQVLYDELHHTVYAEVTTAVELSAEQKSQIEAVYAKRVGAEKVVLSSKVDPDVIGGVIVKAADTILDGSLRTKINRLRQQLLA

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Predict the functional description of the protein sequence below.

Output: Seems to be necessary for the expression of RuBisCO.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MYAVIKTGGKQYKVAEGESIFVEKLDVQAGEEVVFDQVILVANGDDVKVGTPLVEGAKVVASVDKQGKEKKVVTFKYKPKKHSHSKYGHRQPYTKVTVKSIEA

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: What is the functional description of the protein sequence?

Input: MTRIKRGYIARRRRTKIRLFASSFQGARSRLTRTITQQKIRALVSAHQDRGRQKRDFRRLWITRINAVIRANKVYYSYSTLIHHLYKRQLLLNRKILAQIAILNRNCLYMISNEILK

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: What is the functional description of the protein sequence?

Input: MSTVPVKIKPLDHYEGLALPAYETPQSAGMDLRAAVPADEPVSIPPGEWRLIPVGIAIALPAGFEAQVRPRSGLAAKHGISCVNTPGTVDADYRGEIRVNLINHGQANFVVNRGDRIAQMIIAPVTQAVWEIADTLDETTRGTGGFGSTGTK

Output: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


Instruction: Predict the general functional description of the protein sequence.

Input: MKKIVLAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYDENIISLKELLAKFWTIIDPTSLNKQGNDVGSQYRTGIYYVEPSDLEEILNSKEELQKSYSKKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD

Output: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


Instruction: Predict the functional description of the protein sequence below.

Input: MSNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLRERTGKAARIKERLN

Output: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MHRNDSQRLGKPGGAPESLQMANNNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNNSSGAGGNPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF

Output: Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: GTPase that plays an essential role in the late steps of ribosome biogenesis.


Instruction: Predict the general functional description of the protein sequence.

Input: TKKDGEEKVA

Output: Strongly inhibits trypsin and plasma enzyme(s) activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: Can you provide the functional description of the following protein sequence?

Output: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.


Instruction: What is the functional description of the protein sequence?

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Predict the functional description of the protein sequence below.

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Input: MALNLEKKQEIIKAFATKENDTGSCEVQVALLNERIKLLTEHLKANPKDHSSRLGLLELVAQRRNLLKYIKRTDHARYVVLIEKLGIKDR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Predict the functional description of the protein sequence below.

Output: May be involved in recombination.


Instruction: Predict the general functional description of the protein sequence.

Input: MANHKSAEKRIRQTIKRTERNRFYKTKVKNIIKAVREAVAINDVAKAQERLKIANKELHKFVSKGILKKNTASRKVSRLNASVKKIALA

Output: Binds directly to 16S ribosomal RNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.


Instruction: What is the functional description of the protein sequence?

Output: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Input: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD

Output: May play a role in photosystem I and II biogenesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Specifically methylates the guanosine in position 1516 of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.


Instruction: What is the functional description of the protein sequence?

Input: MRSGVFVAVLVVVVFALLTQGQELHVPEREAVANLAARILKIVHAPHDAAAGVPHKRNSELINSLLGISALMNEAGRR

Output: The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neuromodulator (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSRIGKRPISIPGGVDVNIEGNVVTVKGPKGTLTKEMHSLINIAVEEQQIVVTRPDDQPLSRSLHGLTRTLVANMVEGVTKGFSKSLDMVGVGYRAAKQGNKLVLSVGKSHPVELIPFEGIEVEVPAQNKIIVKGMDKELVGDFAAEIRKERPPEPYKGKGIKYENEVVRRKAGKTGAKKGGKK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: Predict the general functional description of the protein sequence.

Input: MKIQDYTKQMVDEKSFIDMAYTLLNDKGETMNLYDIIDEFRALGDYEYEEIENRVVQFYTDLNTDGRFLNVGENLWGLRDWYSVDDIEEKIAPTIQKFDILDADDEEDQNLKLLGEDEMDDDDDIPAQTDDQEELNDPEDEQVEEEINHSDIVIEEDEDELDEDEEVFEDEEDFND

Output: Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.


Instruction: Can you provide the functional description of the following protein sequence?

Output: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


Instruction: Predict the functional description of the protein sequence below.

Output: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.


Instruction: What is the functional description of the protein sequence?

Output: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MNHNVIIVIALIIVVISMLAMLIRVVLGPSLADRVVALDAIGLQLMAVIALFSILLNIKYMIVVIMMIGILAFLGTAVFSKFMDKGKVIEHDQNHTD

Output: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD

Output: This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MGGLSIWHWLIVLLIVALVFGTKKLRNIGNDLGSAVKGFKDGMKEGEAPADAQQLPRSGSVDVNAKETTRSDSNKA

Output: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSRRHAAEKREILPDAKFGDTVLTKFMNNLMIDGKKSVAESIVYNALDRVQTRLKREPLEAFHEALDNVKPSVEVRSRRVGGATYQVPVEVRTERREALAIRWLITAARKRNENTMEERLAAELADACNNRGTAVKKREDTHKMADANKAFSHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKFDPRNLPDLVRRPILTEKATIMMEQDKYTFEVTPKATKPQIRAAIEDLFQVKVVKVNTALPPRRKKRVGKFIGFKPQYKKAIVTIAPGDVEKIRQVLFPEV

Output: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of putrescine from agmatine.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL

Output: Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).


Instruction: Predict the functional description of the protein sequence below.

Input: MYAVVKTGGKQYKVAAGEKLKVEQIPADIGAEITLDQVLAVGAGDQIKFGTPLVSGASVKATVISQGRHDKVKIFKMRRRKHYQKRQGHRQNYTELRIEAINA

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSRVAKAPVTLPNGVSVTLNDRQVEVKGKNGNMSLRLHELVELKQEDDLIIFSPTVDSKEAMMHAGTMRSLLNNLVIGVNEGFEKRLLLIGVGYRAQATGNKVTLNVGYSHPVEYTLPEGVSAETPTQTEIVLKSNDKQQLGQAAANIRGFRPPEPYKGKGIRYSDEHVIRKEAKKK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: What is the functional description of the protein sequence?

Output: Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MDPVKAQQLAAELEVEMMADMYNSLLRMTGACHKKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSLQDEELMKKMQQGVTST

Output: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.


Instruction: Predict the functional description of the protein sequence below.

Output: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.


Instruction: What is the functional description of the protein sequence?

Input: MKTYSAKPSEIEKKWWVIDAKNIVLGRLASRVANMLRGKHKPSFTPHLDCGDNIIIINAEHVKLTGKKANPKDGKIYYRHTGFPGGLKDTTAGKILSSKHPERVIKMAVKRMITRNTLGAKQMSNLYVYANGDHPHMAQQPTVYDFASQNPKNKK

Output: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


Instruction: Predict the general functional description of the protein sequence.

Output: Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.


Instruction: Predict the general functional description of the protein sequence.

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MMKKIDVKILDPRVGQQFPLPTYATSGSAGLDLRACLDDAVELAPGATTLVPTGLAIHIADPSLAAVMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSIWNRGQDSFTIEPGERIAQMVFVPVVQAEFNLVEAFDATERGEGGFGHSGRK

Output: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAKKESFFKGVKSEMEKTSWPTKEELFKYTVIVVSTVIFFLVFFYALDLGITALKNLLFR

Output: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.


Instruction: Predict the general functional description of the protein sequence.

Output: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).