Instruction: Predict the functional description of the protein sequence below.

Input: MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRAAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH

Output: Acts as a gating modifier on both Kv and Nav ion channels, and also acts on blood pressure (By similarity). Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (By similarity). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively) (By similarity). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (By similarity). On sodium channels, tests have been done on human Nav1.7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (By similarity). This toxin also reduces blood pressure (By similarity).


Protein Function Description

Instruction: Predict the functional description of the protein sequence below.

Input: MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit central domain. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.


Instruction: What is the functional description of the protein sequence?

Input: MGRIIFYEDKNFQGRRYECDSDCSDFHAFLNRCNSIRVESGAWVIYERPNFMGYQYVLTRGEYPDYQRWMGLNDRLCSCKMIHFVSGSEYKIQLYDKGDFTGQVYESTEDCPSVVDRFRTREVHSCKVLDGIWIFYEHPNYRGRQYLLEKGEYRKPVDWGAVCPTVQSFKRLME

Output: Crystallins are the dominant structural components of the vertebrate eye lens.


Instruction: Predict the functional description of the protein sequence below.

Output: This is a seed storage protein.


Instruction: Predict the general functional description of the protein sequence.

Output: A methylase that recognizes the double-stranded sequence 5'-CCGG-3', methylates C-2 on both strands, and protects the DNA from cleavage by the HpaII endonuclease.


Instruction: What is the functional description of the protein sequence?

Output: Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (By similarity). In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (Probable).


Instruction: Predict the functional description of the protein sequence below.

Output: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MYMDRHCVYYRKPLLESGTLGTKGNIQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFESLFKQPAENVNQYLTNPKFVERTLRLGGTQPLEVLEAVHRSLVLQRPHDWADCVTWACLHWHSQYANNIRQLLHNFPPEQ

Output: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes an anti cycloisomerization.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: MBP may play some important roles in the allergic reactions and inflammations, since MBP is capable of releasing histamine from mast cells and damaging the epithelial cells of bronchial tubes. Antiparasitic and antibiotic.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the first oxidative step of the phenylpropanoid pathway in higher plants by transforming trans-cinnamate into p-coumarate (By similarity). The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases.


Instruction: What is the functional description of the protein sequence?

Output: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLKGIHPALSPELLKTLAEMGHGDEIVLADAHFPAHSLHKNVIRADGISIDILLEAITPLFEFDAYVDAPLLMMKAVEGDSLDPNVETRYLNAIESAVGFTPNLTCLERFDFYTRAKQAYAVVVSGEIAKYGNIIIKKGVTPIL

Output: Involved in the anomeric conversion of L-fucose.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.


Instruction: Predict the general functional description of the protein sequence.

Output: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development.


Instruction: Predict the general functional description of the protein sequence.

Input: MGYKCTRCKQKVEIDYEYTGIRCPYCGHRILVKERPTTIKRIKAE

Output: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the functional description of the protein sequence below.

Input: MDNKTYEISSAEWEVMNIIWMKKYASANNIIEEIQMQKDWSPKTIRTLITRLYKKGFIDRKKDNKIFQYYSLVEESDIKYKTSKNFINKVYKGGFNSLVLNFVEKEDLSQDEIEELRNILNKK

Output: Transcriptional repressor that constitutively blocks the transcription of the gene for the penicillin-binding protein MecA. Binds palindromic DNA with the sequence 5'-TACA-[AT]-N-TGTA-3'. Regulates genes involved in antibiotic resistance. Binds DNA as a dimer.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: TALFLAMHYTSDIATAFSSVAHICRDVNYGWLIRNMHANGASFFFICIYLHIGRGLYYGSYLYKETWNVGVVLLLLTMM

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the terminal adenosine residue to tRNA . Acts as a nucleotidyltransferase and not a poly(A) polymerase .


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.


Instruction: Can you provide the functional description of the following protein sequence?

Input: AVPDKIDRRESGYV

Output: Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.


Instruction: Predict the functional description of the protein sequence below.

Input: LAKTNFPLNFPIHVRDAGVQWSPLGRLTTGADVRHEIPARVGHRLARWA

Output: Beta-galactoside specific lectin. Has a hemagglutinating activity on erythrocytes.


Instruction: Predict the functional description of the protein sequence below.

Input: GLWSKIKETGKEAAKAAGKAALNKIAEAV

Output: Antimicrobial peptide, active against the Gram-positive bacterium S.aureus, the Gram-negative bacteria E.coli and P.aeruginosa, and the yeasts C.albicans and P.brasiliensis. Has hemolytic activity (40% hemolysis at 128 ug/ml).


Instruction: Can you provide the functional description of the following protein sequence?

Input: QDLDHVFMRF

Output: Myoinhibiting neuropeptide.


Instruction: Predict the functional description of the protein sequence below.

Output: Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cell cytoskeletal keratins K7 and K18.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Terpene cyclase; part of the gene cluster that mediates the biosynthesis of the brasilane terpene glycosides brasilane D and E . The biosynthesis starts with the activity of the terpene cyclase braA that converts farnesyl pyrophosphate into the sesquiterpene alcohol trichobrasilenol . Subsequently, trichobrasilenol is glycosylated by the O-glycosyltransferase braB putatively using UDP-GlcNAc as sugar donor to yield brasilane A . The latter then undergoes two rounds of oxidation performed by the cytochrome P450 monooxygenase braC . In the first round braC hydroxylates C-12 forming brasilane D, which serves as substrate in the second round to establish the epoxide at the bond between C-5 and C-10 and oxidize the alcohol at C-12 to an aldehyde leading to the final product brasilane E .


Instruction: Predict the functional description of the protein sequence below.

Output: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Might catalyze the phosphorylation of aminoglycosides and confer aminoglycoside antibiotics resistance.


Instruction: What is the functional description of the protein sequence?

Input: MSPKTHTLSVLVEDKPGVLARVAALFSRRGFNIESLAVGATECKDRSRMTIVVSAEDTPLEQITKQLNKLINVIKIVEQDDEHSVSRELALIKVQADAGSRSQVIEAVNLFRANVIDVSPESLTVEATGNRGKLEALLRVLEPFGIREIAQSGMVSLSRGPRGIGTAK

Output: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.


Instruction: What is the functional description of the protein sequence?

Output: Involved in both the histidine and tryptophan biosynthetic pathways.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Seems to function only as a co-chaperone, along with cpn60, and in certain cases is essential for the discharge of biologically active proteins from cpn60.


Instruction: Predict the general functional description of the protein sequence.

Output: May bind attractants or detect changes in the extracellular concentration of soluble sugars.


Instruction: Predict the general functional description of the protein sequence.

Output: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis. It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


Instruction: What is the functional description of the protein sequence?

Input: MAIQRTFSIIKPDATARNLTGAINAKIEAAGLRIIAQKRIRLSREQAEGFYGVHKERPFFNDLVTFMISGPVVVQVLEGEDAIAKYRTVMGATNPEQADAGTIRKDFAESIEANSVHGSDAPETAAEEIPFFFSDDEIVG

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: Predict the functional description of the protein sequence below.

Output: ATP synthase subunit beta; part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit . Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). Whereas ctvA to ctvD constitute the core biosynthetic gene cluster, ctvE acts as a self-resistance gene .


Instruction: What is the functional description of the protein sequence?

Output: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.


Instruction: Predict the general functional description of the protein sequence.

Output: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Predict the functional description of the protein sequence below.

Input: MNNKYAEYLPIAIQLMVTLGFISVTLLSSWLLGPKVKSKKKLDAFESGLDPVGNARVQFSIKYFLVATLFVLFDVEVIFFYPWAVNFNYFAEAVNKWEGFVKMLLFMTSLLIGFIYVIKKKALDWE

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).


Instruction: What is the functional description of the protein sequence?

Input: MQHLVLIGFMGSGKSSLAQELGLALNLEVLDTDMIISERVGLSVRGIFEELGEDNFRMFEKNLIDELKMLKNPHVISTGGGIIMHDNFKGLGTTFYLKMDFETIIKRLSKKEREKRPLLNNLTQAKELFEKRQALYEKNASFIINAQGGLKKSLKQALQFIA

Output: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSETFIYPQANLIAGVDEVGRGPLVGAVVTAAVILDPNRPIVGLADSKKLSEKRRLSLYDEITEKALSWSLGRAEPEEIDQLNILHATMLAMQRAVSGLHIVPDYVLIDGNRCPKLQMPSLAVVKGDSRVAEISAASILAKVTRDREMTELDLLFPEYGFAQHKGYPTAFHLEKLAALGATVHHRRSFGPVKRVLGLV

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Required for chromosome condensation and partitioning.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRILGLTGSIGMGKSTTARLFAEAGVPVYDADATVHQIYEGEAAPAVETAFPGTTVNGKVDRALLSARVLHDAAAMQRLEAIVHPMLRAHHQQFLADAEKSGAPVAVVDVPLLYETGGDARVDAVVVVTTSHQVQRARILARQGMTDEKLDALLARQLPDAEKRQRADFVVDTSNGLEPVRAQIREILAATAKMPQRRA

Output: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


Instruction: Predict the general functional description of the protein sequence.

Output: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.


Instruction: Predict the general functional description of the protein sequence.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.


Instruction: Can you provide the functional description of the following protein sequence?

Output: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.


Instruction: What is the functional description of the protein sequence?

Input: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKTMFTLEERVELAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVYQALMAKLA

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: What is the functional description of the protein sequence?

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.


Instruction: Predict the general functional description of the protein sequence.

Output: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.


Instruction: What is the functional description of the protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSVMPDHWIKDKAIQEKMIDPFIDYKESSGILSYGLSSYGYDARIDNKFKIFTNINPVTVDPKNFPLGSFIDKEEDICIIPPNSFVLAKTVEYFKIPKDILVMCVGKSTYARCGIVVNVTPLEPGWEGYVTLEFSNTTPLPAKIYAFEGACQFIFLKGDSQCSLSYNEMKGKYMKQLDVTLPIVNNS

Output: Catalyzes the deamination of dCTP to dUTP.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.


Instruction: Predict the general functional description of the protein sequence.

Output: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: What is the functional description of the protein sequence?

Output: In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the general functional description of the protein sequence.

Output: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.


Instruction: Predict the functional description of the protein sequence below.

Output: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MRPGSTPPSRRKSRPPRRVSPPLPTTSRTSPRRPHAQQQRRASRASPKKRFRPGTRALMEIRKYQKSTELLIRKAPFSRLVREVCMTYACGMNYNWQSMALMALQEASEAFLVRLFEDSYLCSLHAKRVTLYVQDIQLARRIRGVNEGLG

Output: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.


Instruction: What is the functional description of the protein sequence?

Output: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


Instruction: Predict the functional description of the protein sequence below.

Input: MKVAVIKYNAGNIRSVDYALKRLGVEAVVTSDKEVLKAADKVIFPGVGEAETTMLHLKESGMDHFIKELRQPVLGICLGMQLMCRFSEEGNVDCLGIFDTDVKRFAPRKHEEKVPHMGWNTISCLKSDLFKGFTRDEFVYFVHSYYVPVSEFTAAETDYIRPFSAALHKDNFYATQFHPEKSGEAGERIIKNFLEL

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


Instruction: Predict the general functional description of the protein sequence.

Input: MTTETKSADIQLIQRILPHRYPFLLVDKVVEIDGYSSAVGIKNVTMNEPHFQGHFPGTPIMPGVTIVEAMAQTAGVMLGVGMDIIDSELLIYFMNIDNCKFRRKVVPGDVMKMHVETLRGKMGGKIFKFRGTATVEGEVAAQAEFSAYVDLTGEKST

Output: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASAASTAAGSRPGRHTKL

Output: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.


Instruction: Predict the functional description of the protein sequence below.

Output: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.


Instruction: Predict the general functional description of the protein sequence.

Output: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MNLAAYYPVLLFLLVGTGLGIALVSIGKILGPNKPDSEKNAPYECGFEAFEDARMKFDVRYYLVAILFIIFDLETAFLFPWGVALREIGWPGFIAMMIFLLEFLLGFAYIWKKGGLDWE

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the general functional description of the protein sequence.

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFTGLLKDFVRANDARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMAQGPSA

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.


Instruction: Predict the general functional description of the protein sequence.

Output: Selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells.


Instruction: What is the functional description of the protein sequence?

Output: Central component of the spindle assembly checkpoint.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: What is the functional description of the protein sequence?

Input: MGNFHATTIFAVHHNGECAMAGDGQVTMGNAVVMKHTARKVRKLFQGKVLAGFAGSVADAFTLFEMFEGKLEEYNGNLQRAAVEMAKQWRGDKMLRQLEAMLIVMDKTTMLLVSGTGEVIEPDDGILAIGSGGNYALSAGRALKQYASEHLTAKQIAKASLEIAGDICVYTNHNIIVEEL

Output: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.


Instruction: Predict the general functional description of the protein sequence.

Input: MSKTPRKSAPSPSLQLGQAVEWPDRPEAAKLDRVPNPQKDTNFLARFTAPEFTSLCPVTGQPDFAHLVIDYVPGPWLLESKSLKLYLASFRNHGAFHEDCTVAIGKRIATEIKPKWLRIGGYWYPRGGIPIDVFWQTGKLPKDVWVPDQGVQPYRGRG

Output: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.


Instruction: Predict the general functional description of the protein sequence.

Output: Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.


Instruction: Predict the functional description of the protein sequence below.

Output: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLCGIDEAGRGPLAGPVTAAAVILPSSFDFSILKDSKKLTEKKREEVRKTIYADPNVIWAIGWASNYEIDEINILQATFLAMERAYEGLYLKLQEFCKLNNDKFIEPDIIVDGNFIPNIKNCSSIKALVKADDSVYEVMAASILAKTARDRMMIRYSWIYPEYGYEKHKGYGTKKHIEAIRFNGYSPIQRRSFFVKNL

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MHKTAIYPGTFDPLTNGHMDIIRRASMIFDTLIVAVAKSATKEPMFPLSEREEMLRLATRECPSVRVESFDTLLADFAQERGACILVRGLRAVSDFEYELQMGYANASLNPALETIYLMPSLQNAFISSSVIRSILLHKGKISHLVPPVVCEYIQKRRSCM

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: What is the functional description of the protein sequence?

Output: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: What is the functional description of the protein sequence?

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the general functional description of the protein sequence.

Input: MSCYTAILKSVGGLALFQVANGAIDLCRHFFMYFCEQKLRPNSFWFVVVRAIASMIMYLVLGIALLYISEQDDKKNTNNANTNNDSNSNNSNNDKRNESSINSNSSPK

Output: Envelope protein. Required for an early step in virion morphogenesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).


Instruction: What is the functional description of the protein sequence?

Output: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of glycine to tRNA(Gly).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.


Instruction: Predict the functional description of the protein sequence below.

Output: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.;


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Output: Member of the two-component regulatory system RssA/RssB involved in regulation of swarming motility which has been shown to be inhibited by saturated fatty acids. RssA/RssB regulates cellular fatty acid composition, hemolysin production and cell surface topography. RssA/RssB negatively regulates the activity of SlhBA. It can also act as a negative regulator for the control of the swarming initiation.


Instruction: What is the functional description of the protein sequence?

Output: Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the coupling of aromatic side chains of the heptapeptide of vancomycin.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAERLDPDVVLNHVLVPKHEVIDDEEEIEKILEELGVEKDDLPRIHTNDPVVVALSEKLGKRIKPGSLVKIVRDSPTAGKTVVYRVVTNPPE

Output: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKRNVLLLPLLIFLLIAAALLWQLARNAQGDDPTNLESALTGKPVPAFRLESLETPGQYYQAEVLTQGKPVLLNVWATWCPTCRAEHQYLNRLAAQGIRVVGLNYKDDRAKAVAWLKELGNPYALSLSDSDGMLGLDLGVYGAPETFLIDGRGIIRYRHAGDLNARVWESELKPLWDRYSREAAQ

Output: Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).


Instruction: What is the functional description of the protein sequence?

Input: MITKAIYPGTFDPITNGHLDLVTRASAMFSHVILAIADSSSKKPMFTLDERVALAKKVTAPLKNVEVLGFSELMAEFAKKHNANILVRGLRSVSDFEYEWQLANMNRHLMPKLESVFLIPSEKWSFISSSLVKEVARHGGDITPFLPKPVTKALLAKLA

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Predict the general functional description of the protein sequence.

Input: MQKRAIYPGTFDPITNGHLDIVTRATQMFDHVILAIAASPSKKPMFTLDERVALAQKATAHLGNVEVVGFSDLMANFARDRQANILIRGLRAVADFEYEMQLAHMNRHLMPQLESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPDNVHQALMDKLK

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the decarboxylation of D-ornithine and D-lysine . Ornithine is likely the physiological substrate . Has no detectable diaminopimelate decarboxylase activity in vitro .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKIAIGCDEMGYELKQTLITRLKEKNIEFTDFGSFENEKVLYPSIAEKVALEVKNNDYDRGILICGTGIGMAITANKIHGIRAAQIHDSYSAERARKSNDAHIMTMGALVIGPSLAVSLLDTWLDSDFSGGRSQAKVDLMEEIDQKNR

Output: Catalyzes the interconversion of ribulose-5-P and ribose-5-P.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible phosphorylation of UMP to UDP.


Instruction: What is the functional description of the protein sequence?

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MAKFNVLDHNLVPEHHIVSEEEEKTILKELGIEKEFLPRISPNDPVIKALEAIHGKIKDGTVIKIIRNSPTMGHSVYYRVVASEVFK

Output: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biosynthesis of the anti-fungal toxins colneleic acid and colnelenic acid. Can use (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoic acid (9-HPOD) and (10E,12Z,15Z)-(9S)-9-hydroperoxyoctadeca-10,12,15-trienoic acid (9-HPOT) as substrates but has a very low activity with the corresponding 13-hydroperoxides.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.


Instruction: Predict the general functional description of the protein sequence.

Output: Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).


Instruction: Predict the functional description of the protein sequence below.

Input: LLMTGVESGRDAYIAKNYNCVYHCFRDDYCNGLCTENGADSGYCYLAGKYGNACWCINLPDDKPIRIPGKCHRR

Output: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.


Instruction: Predict the functional description of the protein sequence below.

Input: MSFFVQKLSEKATIPTKGSANSAGYDLYAAAECIVPRRGKVLVDTDLAIAVPEGTYGRVAPRSGLASKHSIDTGAGVIDADYRGHVRVLLFNYSDVDFPIKVGDRIAQLILERIVNPPVILVESLEATVRGANGFGSTGV

Output: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MRGEREFRKVRAHGAAVRDPLFTLRLTDYRPRYGERWHPRAIIGLVVSKKTLKHAVKRNRARRRVREALRTMPPELLPGGLPACRAILMLNPGVLTVPFPELQAALAQALQRGAGATKRGGAKGKGGKKGGGQVAGERAGNESGSGRVSAEVNPTSASPASPAEKS

Output: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


Instruction: What is the functional description of the protein sequence?

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Inner capsid (core) component. Displays NTPase, RNA 5'-triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome. Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis. RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.


Instruction: Predict the functional description of the protein sequence below.

Input: MDMLSLNQLQLNIEKRNLFDLCITFLPSAITYIKGANGSGKSSLLRMIAGIMQPSSGNIYYKNSHINNCIKPYCTYIGHNLGLKLEMTVFENLKFWSEIYNSTETVPAAIHYFKLDYLLDEKCYNLSSGIQKIVAIARLIVCQSDLWLLDEVESNLSKENKDLLNNLIVMKANSGGIILLSSHQENVIKSAQILQLK

Output: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the hydrolysis of dGTP into dGMP, which is needed among other for the first step of biosynthesis of dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate).


Instruction: Predict the general functional description of the protein sequence.

Output: Terpene cyclase/mutase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids nectripenoids A and B, as well as cochliquninone D and isocochliquninone E . The pathway probably begins with the HR-PKS ntnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS ntnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of nectripenoids (Probable). The FAD-dependent monooxygenase ntnJ then performs an oxidative decarboxylation at C11 of the ntnH/ntnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (Probable). The membrane-bound polyprenyl transferase ntnF then introduces a farnesyl group before the FAD-dependent monooxygenase ntnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by ntnA (Probable). The terpene cyclase/mutase ntnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (Probable). The cytochrome P450 monooxygenase ntnM may then hydroxylate C1' (Probable).


Instruction: Predict the general functional description of the protein sequence.

Output: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.


Instruction: Predict the general functional description of the protein sequence.

Output: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).


Instruction: What is the functional description of the protein sequence?

Input: MRVAIYPGSFDPITEGHLDIIKRASKVFDEVIVSVLVNPDKKGLFSIEERVKLIEKVTEDIDNVKAESFEGLLVDYMKEKDAKVIIKGLRVVSDFEYELQMAHMNKKLDSSIETVFMMTNAKYSYLSSSSIKQVVMFGGCIEGLVPNKIIKDIINKIGKVR

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biosynthesis of the maltose-1-phosphate (M1P) building block required for alpha-glucan production by the key enzyme GlgE. Catalyzes the formation of an alpha-1,4 linkage between glucose from ADP-glucose and glucose 1-phosphate (G1P) to yield maltose-1-phosphate (M1P).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVEKIRIIGIDPGLRRTGWGIIDFLGNHMHFVASGTLHSDAQLNLASRLHQLHKGLSEVVHQFMPHEAAVEHVFVNKDATATLKLGQARAIALLVPAQAGLPVFEYAPNTIKKSVIGVGHGAKEQIHMMVKRLLPRAEFDGHDAADALALVICHSAHRTNFAHRIKG

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.


Instruction: Can you provide the functional description of the following protein sequence?

Output: PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: What is the functional description of the protein sequence?

Input: MRALYPGSFDPLTLGHLDLIERGCALFGEVVVAVLSNPAKTPAFTLQQRFNQIHVATAHCKGVSVISFDGLTVRCARHNQVDLILRGLRAMSDFEYELQIAHTNRSLAPDFETIFLATAAHHSFLSSSMVKEVARFGGNIDHMVPEVVAQDLHRLFN

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Probable transcription factor.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTAIQHFFKTFFLTELLKGLALTGRYTFRRKFTVQFPEEKTPISPRFRGLHALRRYENGEERCIACKLCEAVCPAMAITIESETRADNTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQILEYHGEKRGDLYFTKEMLLAVGDRYEKDIAAAKAADAPYR

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.


Instruction: Predict the general functional description of the protein sequence.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).


Instruction: Predict the general functional description of the protein sequence.

Output: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).


Instruction: What is the functional description of the protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.


Instruction: Predict the general functional description of the protein sequence.

Input: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVIKMTETGGNYDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDDRLIYTANDLKVGLFQDTSAF

Output: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.


Instruction: Predict the general functional description of the protein sequence.

Output: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.


Instruction: Predict the functional description of the protein sequence below.

Output: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


Instruction: Predict the functional description of the protein sequence below.

Output: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.


Instruction: What is the functional description of the protein sequence?

Input: MRLCDRDIEAWLDEGRLAITPRPPVERINGATVDVRLGNKFRTFRGHTAAYIDLSGPKDEVSAALDRVMSDEIVLNDGEAFFLHPGELALAVTYESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWQGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRRQDAKYRDQQGAVASRIDKD

Output: Catalyzes the deamination of dCTP to dUTP.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.


Instruction: Predict the general functional description of the protein sequence.

Output: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the synthesis of activated sulfate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).


Instruction: Predict the general functional description of the protein sequence.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Output: [Hexon-linking protein-N]: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.;


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


Instruction: What is the functional description of the protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.


Instruction: Predict the functional description of the protein sequence below.

Input: MPIKSDKWIRRMAESHQLIYPFEPKQVRETPSGKVISYGTSSYGYDVRCADEFKIFTNINASIVDPKNFDPNGFIDLKANVCIIPPNSFVLARTVEYFKIPRNILTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTNLPAKIYANEGVAQMLFLESDEVCDISYKDRGGKYQGQKGVTLPVA

Output: Catalyzes the deamination of dCTP to dUTP.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MIALIQRALSASVVVEGNIVGEIGPGLLVLLGVEQGDTEQKAQRLCERVLGYRIFSDENDKMNLNVQQAGGSVLVVSQFTLVADTQKGMRPSFSRGAIPQEADRLYQYFVAQCRERGVKTETGLFAADMKVSLVNDGPVTFWLQV

Output: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.


Instruction: Predict the general functional description of the protein sequence.

Output: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.;


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


Instruction: Predict the general functional description of the protein sequence.

Output: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.


Instruction: What is the functional description of the protein sequence?

Output: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.