Instruction: Can you provide the functional description of the following protein sequence?

Input: MSKKKGSNTLAENRKARHDYFIEETYEAGIELVGTEVKSIRQGKANLKDSYAEIRNGEVFVRNMHISPYEQGNIYNKDPLRDRKLLLHKSEIYKLVGFTTQQGYTLIPLSLYLKHGRVKVSLAVAKGKKNYDKRDAMLEKAAKREMDRQIKERSRY

Output: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.


Protein Function Description

Instruction: What is the functional description of the protein sequence?

Input: MIQSFTRLAVADNSGAKELMCIKVLGGSKRRYATLGDVIICSVKKALPNGKIKKGQVVKAVVVRTKKEVQRGNGSLIRFDENAAVILDNKREPIGTRIFGPVGREVRYANFMKIVSLAPEVL

Output: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.


Instruction: Predict the general functional description of the protein sequence.

Input: MNLEALCKEAELSFYDDELVSENGKKIYRIYVQKEGGVNLDDCARLSEILSPIFDVEPPVNGEYFLEVSSPGLERKLSKIEHFAKSIGELVKITTNEKEKIEAKIIAVDDENITLENLENKEKTTINFNDIKKARTFMEW

Output: Required for maturation of 30S ribosomal subunits.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Activates expression of the rhaSR operon in response to L-rhamnose.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRHYEIVFMVHPDQSEQVAGMIERYTGSITEAGGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAGQEVIDELETAFRFNDAVLRNMIMRTKAAITEQSIMLKQKEERAERAPRREERAEAKPEAAAE

Output: Binds together with S18 to 16S ribosomal RNA.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Predict the functional description of the protein sequence below.

Input: MVKLAFPRELRLLTPSHFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS

Output: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


Instruction: Predict the functional description of the protein sequence below.

Input: MNETNDIDQLIYLFSKLPGLGSRSARRIVLYLLQDKDVRLKSLINNLINIDKKIVKCEICGNMDTENICRICSSEYRDKSVIAIVETVAELWAMERSGNFKGLYHVLGYNLSAASRKNPSMLRLPELLTRCFAANIKEVIIATNSTLEGQTTAYFITEYLKEHPAKISRLASGIPIGGELDYLDEGTLSAAINLRQPFE

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: Predict the general functional description of the protein sequence.

Input: MKTLLLTLVVVTIVFLDLGYTMTCCNQQSSQPKTTTTCAESSCYKKTWRDHRGTITERGCGCPNVKPGVQINCCKTDECNN

Output: Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.


Instruction: What is the functional description of the protein sequence?

Input: MAVNVQQYLNKEYEVECDGQMVRLKPVKAWVLQPKGRKGVVIGLFKCPNGKTLRKAIGKIE

Output: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.


Instruction: What is the functional description of the protein sequence?

Input: MKYTRHSKILELIDKNEIETQEELSERLKDMGFTVTQATVSRDIKELRLIKVLTKNGKYKYATLQSQENILSDRVVKIFKNSVVSIDYAGNLIVIKTLTGSAQAAAAAIDAGDMNDVVGTIAGDDTIFIVIRDEKNVPSTIEHFRKLMK

Output: Regulates arginine biosynthesis genes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MASEIFGTAAVFWVLIPVGLLGGAILLKLQGD

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: Predict the general functional description of the protein sequence.

Output: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.


Instruction: What is the functional description of the protein sequence?

Input: MNEKPVLGIQDIQNLLPHRYPFLLVDKILSYDLNTRSVVAQKNVTINEPFFAGHFPGAPIMPGVLILEALAQAAGVLLGIILENDRDKKIALFLGIQKAKFRQPVKPGDVLTLKAEFSLISAKGGKAFAQAFVGSQVVAEGELSFVLVKKESI

Output: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


Instruction: Predict the functional description of the protein sequence below.

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Predict the functional description of the protein sequence below.

Input: MRDMMGMMKQAKELQAKMKAMQDEIATMEASASSGGGLVTVTLSGKGTLSALKIDPSLMKEDEVEILEDLIIAAHNDAKAKLEAAMAEKTQSLTAGLPIPPGFKLPF

Output: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


Instruction: What is the functional description of the protein sequence?

Output: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


Instruction: Predict the general functional description of the protein sequence.

Input: MSTISRDSCPALRAGVRLQHDRARDQWVLLAPERVVELDDIALVVAQRYDGTQSLAEIAQTLATEFDADASEIETDVIELTTTLHQKRLLRL

Output: Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAGLSKDQLIESISSMSVIELSELVKALEEKFGVSAAAPAPAVVAGTSPAVATEEKTEFNVILGSVGTSKINVIKVVREVTGLGLKEAKDLVDGAPKTVKENVAKAEAEEIKKKFTEVGATVELK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MNKKQLNFEKSLKKLEEIVSEIENADPDLDKALALFAEGAELIKSCLAKLNETKKKIEVIISSGKTEFFKE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.


Instruction: What is the functional description of the protein sequence?

Input: MINDIKKDAQDRMGKSIEALGRNLASIRTGRAHPSILDSVKVPAWGSEMPLNQVAAVSVEDARTLKIVAHDKNLSAAIEKAILTSDLGLNPSSAGTTIRVPMPALTEETRKGYTKQASAVAEDAKVAVRNVRRDALADLKKLTKDKEISEDEERRAADEIQKLTDKFVAEIDAAFKAKEKDLLAV

Output: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).


Instruction: Predict the general functional description of the protein sequence.

Output: Confers resistance to chloramphenicol.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Transports acetate.


Instruction: What is the functional description of the protein sequence?

Input: MSSGGLLLLLGLLTLWAELTPISSRERHPDCDKPPDTGRCGNNVRAFYYKPSTNKCVQFIYGGCNANGNHFKSDHLCRCQCREND

Output: Beta-1-bungarotoxin is a presynaptic neurotoxin of the venom. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and blocks voltage-gated potassium channels (Kv) (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


Instruction: What is the functional description of the protein sequence?

Output: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEDRSPQNSIQGCQNQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS

Output: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.


Instruction: What is the functional description of the protein sequence?

Input: MGLHAYPKAARLTKTDEFSSVFALRPVRRSRHFVLYVRANGDRPARLGVVIGKKFAKRAVERNLIKRQCRELFRLRQPLLGGRDVLIRLQAKFPRQDVPTVAAFKRICREELAQLFEVATRPLSAPPAATPPQPTAGSTP

Output: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MALLEIIHYPSKILRTISKEIVSFDSKLHQQLDDMRETMIASEGIGLAAIQVGLPLRMLIINLPREDGVQHKEDCLEIINPKFIETKGTIMYKEGCLSVPGFYEEVERFEKVKIEYQNRFAEVKVLEASELLAVAIQHEIDHLNGVLFVDKLSILKRKKFEKELKELNKNPKSKS

Output: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


Instruction: Predict the general functional description of the protein sequence.

Input: MVNWQVIGQLLSATLIVLAGPAVIFVLAFKKGNL

Output: A core subunit of photosystem II (PSII).


Instruction: What is the functional description of the protein sequence?

Input: QTFHYSQGWTN

Output: Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: ARSDNFVRL

Output: FMRFamides and FMRFamide-like peptides are neuropeptides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPRSLKKGPFIDFKLEKRILDLNAKDEKKVVKTWSRSSMISPDFVGHTIAVHNGKTHVPVYVSDNMVGHKLGEFAPTRTFRGHAGGKAEKGGSAPRKK

Output: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


Instruction: Predict the general functional description of the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Input: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE

Output: Binds to the 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MRSSAKQEELVRAFKALLKEEKFSSQGEIVLALQDQGFENINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPASGFSVRDLYEAILELFEQEL

Output: Regulates arginine biosynthesis genes.


Instruction: What is the functional description of the protein sequence?

Output: The glycine cleavage system catalyzes the degradation of glycine.


Instruction: Predict the functional description of the protein sequence below.

Input: MPKKNEAPASFETALSELEHIVTRLESGDLPLEDALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEEASPEPFIADNE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.


Instruction: Predict the general functional description of the protein sequence.

Input: MSITKDQIIEAVSAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPAEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKSLEEAGAEVEVK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the proton-dependent transport of sialic acid.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: Predict the functional description of the protein sequence below.

Input: MSSGGLLLLLGLLTLWAELTPVSGQDRPVKPGLCPPRPQKPPCVKECKNDWSCRGEQKCCRYGCIYECRDPIFVK

Output: Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAKLHDYYKDEVVAKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLTAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Output: Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.


Instruction: Predict the functional description of the protein sequence below.

Output: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.


Instruction: Predict the general functional description of the protein sequence.

Input: MAQNKANTVSQLQSLKNKSGKSYNQLAEETGLTNVYVAQLLRRQAHLKPETAPKLKAALPELPEELIHEMMKPPLRSYDPNIIQDPTVYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFYCSVDKVQGVDGKDRVVLTFDGKYLPHSEQKTEHMVSRTRPLEKQ

Output: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates guanosine-37 in various tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKYTNDELLEAFGEMTLVELSEFVKAFEEKFDVEAAAPVAAVAAVAGAAAPAEEEKDEFDVILSAVGDKKIQVIKAVRAITSLGLAEAKALVDGAPKAVLEKAKKEDAEKAKAQLEEAGASVELK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: Predict the functional description of the protein sequence below.

Output: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


Instruction: Predict the functional description of the protein sequence below.

Input: MSIPNNLRYSEEHEWVKTEGNEVVIGITHFAQNELGDIVFVELPEVGATIEADEPFGSVESVKTVSELYAPVSGKVVAVNEELSDQPELVNESPYEGAWMVKVELSDASQVEKLLTAEKYAEMTNQD

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.;


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.


Instruction: Predict the functional description of the protein sequence below.

Input: MPKADIHPTWYPEAKIICNGEVVMTVGSTQPEIHVEVWSGNHPFYTGTQKMIDTEGRIDRFQKRYGNLGKGGSKPNKKGDQK

Output: Binds the 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKRIAFVFSTAPHGTAAGREGLDALLATSALTDDLTVFFIADGVFQLLSGQKPDAVLARDYIATFKLLGLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF

Output: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.


Instruction: What is the functional description of the protein sequence?

Input: MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF

Output: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.


Instruction: What is the functional description of the protein sequence?

Input: MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA

Output: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


Instruction: What is the functional description of the protein sequence?

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Predict the functional description of the protein sequence below.

Input: MALSIHDKKIIVSKINKISNTALSAVTADLQGVCVNKINELRKSGREVGVKMSIVQNTLLSLAIKNTVFECLKKKLKGSTFIAYSMIHPGSGARLFKEFSKKNTQFKITGAAFEGKLLSILEINQLADMPTYKEAIIKLLLTWKMLIAGKLIYTLSAIKQKKETS

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Predict the functional description of the protein sequence below.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTEYALILISTVLVNNFVLVKFLGLCPFMGVSRKVETATGMGLATTFVLTLSSVCSYLVNEYLLAPLGLEYLRTIAFILVIAAVVQFTEMVVHKTSPLLYNVLGIFLPLITTNCAVLGVALLNVQEAHGFIESALYGLGAAVGFSLVLVLFASIRERVAVADVPLPFKGNAIALITAGLMSLGFMGFIGLVK

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Specifically methylates guanosine-37 in various tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Output: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MILGIGTDLANIDRMEKTLARFGERFRNRVFTPLEQAKAERRADVAGTYAKRWAAKEACSKALGTGLRMGISWKDMSVANLETGQPVMRLTGWAAERLASMTPPGHEAVVHVSLTDDHPWAQAFVVIEARPRAAPPA

Output: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.


Instruction: Predict the general functional description of the protein sequence.

Input: MANHKSAAKRAKQSEARRLRNKSTRSSMNTAVKKVRTAKEAGTDNATDLLNSAKSLIAKAAKKGVIHQNTAARKISRLTKSLG

Output: Binds directly to 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPIDTVMETLPGYAKDIKLNYSTLVRQNTELTPQQLWGTVVASAIATRNDTLTAAALEDGAQHLSEQALEAARIAAALMSMNNIFYRFQHLSSNEKYATMPARLRMNGMRTHGVEPVDFELWSLAVSAINGCGKCVDSHEKVLREKGAGEDLVLAAVRVASVIHAIGAVLDAEKVHQPEAAMA

Output: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


Instruction: Predict the general functional description of the protein sequence.

Input: MTDLRHYDVIVSPSITEKSTLVSEQNQVVFNVAKGASKPEIKAAVEALFGVKVTAVNTLVRKGKLKRFRGFAGKQKDVKKAIITLAEGQSIDVSTGL

Output: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.


Instruction: Predict the functional description of the protein sequence below.

Input: MQGKSIRLGIVVAEFNYDITQLMLQKALSHAKFLNAEVKVVIKVPGTFDMPLAIKKLLEKDFIDAVVTLGAVIKGETKHDEIVASQTARKIVDLSTEFNKPVTLGIIGHGATHEQAVERIEEYATRAVEAAIKLVQRTRKIDELKEVKETVIID

Output: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


Instruction: Predict the functional description of the protein sequence below.

Output: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


Instruction: What is the functional description of the protein sequence?

Input: MHELSIAQSLLALIEDEMAKHGKEKLITVKVRHGRLSSVVPEALSMAFEVMTADSRLAGAALVMEETPVLLRCRDCSREFTPDPPTAAFAPCPGCGQELGHTVVSGRELYIEYLELE

Output: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.


Instruction: Predict the general functional description of the protein sequence.

Output: Unable to convert squalene, botryococcene, cycloartenol, zymosterol or lanosterol to mono-, di-, tri- or tetramethylated derivatives.


Instruction: Predict the general functional description of the protein sequence.

Input: MIGIDIVSIARIEKCVKRFKMKFLERFLSPSEIVLCKDKSSSIAGFFALKEACSKALQVGIGKELSFLDIKISKSPKNAPLITLSKEKMDYFNIQSLSASISHDAGFAIAVVVVSSSNE

Output: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for morphogenesis under gluconeogenic growth conditions.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MIKMFKYKQVIVARADLKLSKGKLAAQVAHGAVTAAFEAYKKKREWFEAWFREGQKKVVVKVESEEELFKLKAEAEKLGLPNALIRDAGLTEIPPGTVTVLAVGPAPEEIVDKVTGNLKLL

Output: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.


Instruction: What is the functional description of the protein sequence?

Input: MSIPVMQLKHELALKAREEYLRKELPLKVRANTSRMNPGAKTWIPQINHRKSRNHYNRKETCQFPPLYNVEAKINHSYSAFYRPFTKRENGLWYANPYYMQHGPNGNYHHVYY

Output: Has a role in meiosis.


Instruction: Predict the general functional description of the protein sequence.

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Predict the general functional description of the protein sequence.

Input: MDILSLGWSALMVVFTFSLALVVWGRNGF

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: Predict the functional description of the protein sequence below.

Output: Synthesizes alpha-1,4-glucan chains using ADP-glucose.


Instruction: Predict the functional description of the protein sequence below.

Input: MNLATIASEIEVVKTNQKTIESKIDQILAKIGSTPDESSNLESVAAKIISDLTKEMKECHCNKEIVEILNKDKAIIPSPEQDSIQKRLSEPQYTFPNFDVGNEGMGSSTNPNALKWPPTEKPQPWPPR

Output: Plays a role in virus cell-to-cell and plant-to-plant transmission. Interacts with virion icosahedral capsid and movement protein, thereby facilitating virion cell-to-cell transmission through plasmodesmata opened by viral movement protein. Also interacts with aphid transmission factor, attaching the virion to aphid stylet when the animal feeds on an virus infected plant. Aphid saliva may later detach the virion, inducing release of infectious particles when the animal feeds on a new plant (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: DEPTTDLPICEQAFGDAGLCFGYMKLYSYNQETKNCEEFIYGGCQGNDNRFSTLAECEQKCIN

Output: Inhibits chymotrypsin and thus avoids the accidental chymotrypsin-mediated activation of prophenoloxidase. This enzyme is required by the insect immune system to produce melanin which is used to engulf foreign objects.


Instruction: Predict the general functional description of the protein sequence.

Input: MSLNITENESISTAVIDAINSGATLKDINAIPDDMMDDIYSYAYDFYNKGRIEEAEVFFRFLCIYDFYNVDYIMGLAAIYQIKEQFQQAADLYAVAFALGKNDYTPVFHTGQCQLRLKAPLKAKECFELVIQHSNDEKLKIKAQSYLDAIQDIKE

Output: Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MANIKSAKKRAIQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAAQKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQINKLA

Output: Binds directly to 16S ribosomal RNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYLDDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Output: Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM

Output: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.


Instruction: What is the functional description of the protein sequence?

Output: The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGKRERSEVYSEAVKRIL

Output: Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). Acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. Acts with RelB as a corepressor of relBE transcription (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MDPQNALYYQPRVPTAAPTSGGVPWSRVGEVAILSFVALICFYLLYLWVLRDLILVLKARQGRSTEELIFGGQAVDRSNPIPNIPAPPSQGNPGPFVPGTG

Output: Involved in the viral transport within, and between cells.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis.


Instruction: Predict the general functional description of the protein sequence.

Input: ADDDLEGFSEEDLKAIKEHRAGLAA

Output: Unknown. Is not toxic to mammals.


Instruction: Predict the general functional description of the protein sequence.

Input: TPEHQRYVELFIVVD

Output: Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.


Instruction: What is the functional description of the protein sequence?

Input: MSRRLILILVLVAMLVKTMAGMESKWVETTYEIKKRSGTSEKERESERLLGVVNPLIKCFRSPCPGRRAISEQT

Output: Possesses antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as against the fungus C.tropicalis. Also possesses a relatively high hemolytic activity.


Instruction: Predict the functional description of the protein sequence below.

Input: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Output: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.


Instruction: What is the functional description of the protein sequence?

Input: MDIINIAWAALMVIFTFSLSLVVWGRSGL

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: Predict the general functional description of the protein sequence.

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MNLVTTIITITITLSAVLATISFWLPQISPDAEKLSPYECGFDPLGSARLPFSLRFFLIAILFLLFDLEIALLLPLPWGDQLNAPTLTLLWSTAVLALLTLGLIYEWTQGGLEWAE

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.


Instruction: Predict the general functional description of the protein sequence.

Input: MKKSIFSKKLLVSFGSLVALASIPLIAISCGQTNTDKSQQPGSGSSTSGDQSGTTTGGHSGSGTSTSGGQSGTTSGSGTTTGEQTETAPKSPESGSQEATPKSPESGSQEATPKSPESGSQEAAPKSSESGSQEAAPKSSESGSQEAAPKSSESGSQKTT

Output: Responsible for the antigenic diversity for host adaptation.


Instruction: Predict the functional description of the protein sequence below.

Output: Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Forms a ribonucleoprotein complex with viral RNA. Binds microtubules and modulates microtubule stability. Can bind double-stranded DNA. Triggers host hypersensitive defense reaction in incompatible plants harboring resistance (R) proteins.


Instruction: Predict the functional description of the protein sequence below.

Input: MTDAFQKLFQQMLQSGQEMARAFNPALEHFDMRAMEKLVPTIPADMLEMWFGKTFNREGLDAKTRLLLTIGAITVQGALAEPQLRMTVRQALAAGATKREIAETIFQMSMFGGLPAMQKALEIAQSVYAEEDEE

Output: May have a role in the regulation of NDH-1 biosynthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. It is responsible for directing gene expression in the forespore compartment of developing cells of Bacillus.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKKIEAIIRPFKLNEVKLALVKGGIGGMTVVKVSGFGRQKGQTERYKGSEYSIDIIDKIKIEIIVSDDKVNSITEIIIKTAKTGEIGDGKIFISDVEQVIRIRTNDLNSAAL

Output: P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase, so activating the enzyme (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.


Instruction: Predict the general functional description of the protein sequence.

Output: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Chelates iron to the siroheme precursor.


Instruction: Predict the general functional description of the protein sequence.

Output: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).


Instruction: What is the functional description of the protein sequence?

Output: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination. Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle. Recruits the multifunctional OPG102 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities. Interacts with nucleoside triphosphatase I/OPG123, a DNA-dependent ATPase required for the termination of early transcripts. Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles.


Instruction: What is the functional description of the protein sequence?

Input: MGIQHEFDIIINGDIALRNLQLHKGDNYGCKLKIISNDYKKLKFRFIIRPDWSEIDEVKGLTVFANNYAVKVNKVDDTFYYVIYEAVIHLYNKKTEILIYSDDENELFKHYYPYISLNMISKKYKVKEENYSSPYIEHPLIPYRDYESMD

Output: Inhibits antiviral activity induced by type I interferons. Does not block signal transduction of IFN, but is important to counteract the host antiviral state induced by a pre-treatment with IFN (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MAYNPITPSKLIAFSASYVPVRTLLNFLVASQGTAFQTQAGRDSFRESLSALPSSVVDINSRFPDAGFYAFLNGPVLRPIFVSLLSSTDTRNRVIEVVDPSNPTTAESLNAVKRTDDASTAARAEIDNLIESISKGFDVYDRASFEAAFSVVWSEATTSKA

Output: Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: VMNLWPGVRLRVTEGWDEDGHHSEESLHYEGRAVDITASDRDRNKYAMLARLAVEAGF

Output: Intercellular signal essential for a variety of patterning events during development.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: VHMARNMXVPPXXAD

Output: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: DAHNEDEEHAEGS

Output: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: AVNVNTNVSAMTAQRYLNQA

Output: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


Instruction: Predict the functional description of the protein sequence below.

Input: QVNFSPGWGT

Output: Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).


Instruction: Can you provide the functional description of the following protein sequence?

Input: QVNFSPGWGT

Output: Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFTQRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Output: Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB12 (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Potential transporter for phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKSVITTTISAADAAGRYPSTSDLQSVQGNIQRAAARLEAAEKLGSNHEAVVKEAGDACFSKYGYLKNPGEAGENQEKINKCYRDIDHYMRLINYTLVVGGTGPLDEWGIAGAREVYRTLNLPSAAYIAAFVFTRDRLCIPRDMSAQAGVEFCTALDYLINSLS

Output: Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.


Instruction: What is the functional description of the protein sequence?

Input: MVLTDPIADYLTRIRNANMVRHESLVVPASKMKKDISEILKREGFIRDYEVIDDDKQGVIRIFLKYGKNNERVISGLKRISKPGLRSYVKSDAVPKVLNGLGIAIISTSEGVITDKEARAKNVGGEVLAYVW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MRNISLTTTIITTTDTTGNGAG

Output: This protein is involved in control of the biosynthesis of threonine.


Instruction: What is the functional description of the protein sequence?

Input: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNGGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLVGTLVALWLGIGATLPIEKSLTLGLFSIK

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: What is the functional description of the protein sequence?

Output: May be involved in proton extrusion. Indirectly promotes efficient inorganic carbon uptake into chloroplasts.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRIRLISVGGRMPGWAAEGYREYAQRLGGGISLELVEIPLGRRGKGADPRRALDEEGRRMLKALGDEQVVALDVRGKAWDTPALARELDGWLHDGRDLALLVGGPDGLHPDCLARAERRWSLSPLTFPHMLVRVLLAEQLYRAWSLLQGHPYHRA

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MVVLGRVIGPHGIRGQIKVTPFTEHIDGLMEYPVWWLSNDEKSWQIVHPTSFSVHDSLLIITLEEYSDRTNASGLKGWLIAVPRSQLPQLSEDGKEGYYWSDLIGISVVNTQGEFIGTVAGLFETGANDVLRIQLPGGKEELIPFVDQVVRQVDMRSRQIMVDWELDY

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: What is the functional description of the protein sequence?

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MISGSDLRKGTTFELDGQVYTVIDFLHVKPGKGAAFVRTKLRNVIMGGVTDRTFNPTDKLQEAIIERKEMQYLYSDGELYYFMDQETFEQIPLNHEKVEDAIKFLKENMNAVIKFYKGEAFSVEAPNFVELLITECEPSVKGNTATTAMKTAVVETGATVMVPMFVEEGNTIRIDTRTGEYMERV

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.


Instruction: Predict the general functional description of the protein sequence.

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: What is the functional description of the protein sequence?

Input: MKLHTLRPAKGSVKTSKRIGRGTGSGRGGTSTKGHKGAKSRSGYSSKIGFEGGQMPLQRRLPKFGFKPLNKIEFKPINLDELLELIEKTGASVIDTALMNQNGLIGKNDKVKVLARGEVKSIKAEIIAHAFSASASEAITNAGGKVTLIG

Output: Binds to the 23S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


Instruction: Predict the general functional description of the protein sequence.

Input: MTRVKRGYVARKRRKRVLQLTQGFRGAHSVLFRTANQQNIKALRYASRDRARRKRDFRRLWITRINAGARKQGLSYSQLMHRFKKCGILINRKVLAQLALLDTKTFNQLVFYTDL

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Predict the functional description of the protein sequence below.

Input: MASYYSNDFRPGLKIMFEGEPYAVESSEFVKPGKGQAFARVKMRRLLTGGRVEKTFKSTDSLEGADVNDMNLTYLYNDGEFWHFMNNETYEQLQADAKAVGDNGKWLIDQAECIVTLWNGQPIAVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQVGEIIKVDTRSGEYVSRVK

Output: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.


Instruction: Predict the general functional description of the protein sequence.

Input: MTTINVEVRNDQGKGASRRLRAANKFPAIVYGGSEAAISIALDHDTTKNLELKPGFYDSVLTLVIDGKETKVKVQAVQRHAFKPKLTHIDFVRV

Output: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSLSEARFHDLVDATQQALEDLFDESDLDLDMENSAGVLTVKFDNGSQLIFSRQEPLRQLWLADRSGGFHFDYDEESGKWVCEKTEELLGEMLERIVWERAGEKLDFDEI

Output: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in cell division and chromosome segregation.


Instruction: What is the functional description of the protein sequence?

Input: MIQEQTMLTVADNSGARRVMCIKVLGGSCRRYASIGDVIKITIKEAIPRGKVKKGDVLKAVIVRTKKGVRRPDGSIVRFDGNACVLLNNNEQPIGTRVFGPITRELRIEKFMKIISLAPEVL

Output: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MALTLEQKQQVVAEVSEVAANAYSAVAAEYHGIGVAKLTKLREQAREKGVVLKVVKNTLAKRAFEGTKFESMSDRMTGPLLLAFSMEDLGSAARVIFDFSKDHKALETKLVSVGGVVYGPEELERVSKLPTRDEAISILMATMNAPVTKLVQTMNAVPGKFVRTVAAIKDAKEAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.


Instruction: Predict the general functional description of the protein sequence.

Input: MNNNFTKYLSTAPVIGVLWMTFTAGFIIELNRFFPDVLYFYL

Output: May help in the organization of the PsaE and PsaF subunits.


Instruction: Predict the functional description of the protein sequence below.

Input: MIEKVPMTAGGYAALEVELKQRQSVDRPRIIEHIAEARSHGDLSENAEYHAAKEEQSHNEGRIAELEDKLARADIIDISKLSGDTIKFGATVTLIDEDTEKKAVWQIVGEPEADAKKGRISITSPLARALIGKKKGASVEVVAPGGAKAYEITKVEWR

Output: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


Instruction: Predict the functional description of the protein sequence below.

Output: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSLNRSEKEAVISDVTGLAAKAQTLVMAEYRGITVADMTKLRSTARSNGVSLSVLKNTLARRAVTGSGFEIVSDLMTGPLIYGFSEDAVAAARVVADFAKTNVKLVIRGGAYGGKALDVNGVKQLASIPSKEVLLAQLLGLMQSPISRTARVLAAIAEKKGAGVADAPVEAAAEAVAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MVRIRIRAIGKIKESFIRDAIADYAKRMCSFCQVECIEYPEAPVPDTHPSTIEMACVSEGEKLCSGIDSLDYVIILDRTGKQVSSEGLAEVIRRCEIEGPYQLVFIIGGPHGLSKDCLQKGNIILSLSAMTFPHQIARLLLYEQLYRAFTIIRGLPYHR

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MANRIKKGDQVVINTGKDKGKQGEVVRVDGDRVIVSNANLIKRHTKPNPQAGVAGGVVEREASIHISNVNIVNPATGKGERVGFKVLEDGRKLRVFRSSGEALDA

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Predict the functional description of the protein sequence below.

Input: MEMLQGLLLLMLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQSVLPPLPQVVCTYRDVRFESIWLPGCPRGVDPVVSYAVALSCHCGLCRRSTSDCGGPKDHPLTCDHPQLPGLLFL

Output: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.


Instruction: What is the functional description of the protein sequence?

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPRATNKPATRRRRKKILNKAKGYWGRRSKVYKVAKHAVEKGLQYAYRDRRQKKRRFRRLWITRINAATRQHDVSYSQFMGQYRKSDLDMNRKVLADLAVHDPDAFEQIVDHVME

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phosphorylation of thiamine to thiamine phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MANRIKKGDQVVINTGKDKGKQGEVVRVEGDRVIVSNANVIKRHTKPNPQAGVAGGVVEREASIHISNVNIVNPATGKGERVGFKVLEDGRKLRVFRSSGEALDA

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTYLGSIEALLFVAGEDGLSLRQMAELLSLTPSALIQQLEKLAKRYEEDDDSSLLLLETAQTYKLVTKDSYMTLLRDYAKAPINQSLSRASLEVLSIIAYKQPITRIEIDDIRGVNSSGAITRLIAFGLIKEAGKKEVLGRPNLYETTNYFLDYMGINQLDDLIDASSIELVDEEVSLFSMDSINTEDKENNEN

Output: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGLEREDVEILACTRGWLRYRLPQRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD

Output: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTGTGKTVTRVDLCEAVYKKVGLSRTESSAFVELVLKEITDCLEKGETVKLSSFGSFMVRKKGQRIGRNPKTGTEVPISPRRVMVFKPSAILKQRINSNGAGGKTD

Output: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.


Instruction: What is the functional description of the protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Predict the functional description of the protein sequence below.

Output: The glycine cleavage system catalyzes the degradation of glycine.


Instruction: Predict the functional description of the protein sequence below.

Input: MPRKGSVPKRDVLPDPIHNSKLVTKLINKIMLDGKRGTAQRILYSAFDLVKERSGREAVEVFEEAIDNIMPVLEVKARRVGGSNYQVPVEVRPERRTTLGLRWLVNYSRLRGEKTMEERLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTKKAEELKMHEKDTGSSEVQIALLTGKIETLSAHIKQFKKDKHSSVGLLRAVNRRKKLLEYLKKNKFDSYKNVLTQLNLRK

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: What is the functional description of the protein sequence?

Output: Responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots.


Instruction: Predict the general functional description of the protein sequence.

Output: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MKTLLLTLVVVTIMCLDLGYTTKCYVTPDVTSQTCPDGQNICYTETWCDAWCGSRGKRVNLGCAATCPKVNPGVDIICCSTDNCNPFPKRS

Output: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.


Instruction: What is the functional description of the protein sequence?

Input: MPKKDVRAFLYDILENMKDIIDFTNDMTFDEFLKDKKTQKAVIRSLEVIGEAVKNLPEDFINKYPQVPWKGMARLRDKLIHHYFGINYEIIWDIVINKVPNDIKEIEEIIKDIEGEDENSI

Output: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MJ0128. Neutralization may be due to AMPylation by MJ0128.


Instruction: What is the functional description of the protein sequence?

Output: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the proton-dependent transport of sialic acid.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Required for efficient assembly and nuclear export of the 60S ribosomal subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Acts as a chaperone.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds to the 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSSRSRHDVKGPAGVSAHGPSTRQLRVAEEVRRVLAELFARTEFRDPELLDVRITVTEVRISPDFRHATAFVTRLGRSDVEVLLPALKRVAPFLRTGLSKALNLRTVPEIHFQPDTALDNAMELDEIMRSPEVQRDLNSKPE

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MIEINVYYKKWYSTIKKPKIFVKNVIKSSLINLNIYEYKPIISIVLANNILLQKLNYEYRNKNKPTNVLSFPYDKLNKKCNLGEIFLSLDTLIQESIDLNIPIEHHTCHMLIHGLLHILDYNHEEPLMQYIMESIEIKLLDKLGIRNPYVSRETIYP

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSLSDPIANFLTSIRNGQLSMNKVVTVSYSYVIHAILQILLSEGYIDGFTEKLRSTNIKFFEVKLKYYNGVPVINRICRVSKPGKRCYCSAKGMPKFYNGLGLYIISTSKGIMSDYNARKSGVGGEILCGVF

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: What is the functional description of the protein sequence?

Input: MRTYEVMYIVRPNIEEDAKKALVERFNGILATEGAEVLEAKDWGKRRLAYEINDFKDGFYNIVRVKSDNNKATDEFQRLAKISDDIIRYMVIREDEDK

Output: Binds together with S18 to 16S ribosomal RNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MDLKQYVSEVKDWPSAGVSFKDITTIMDNGEAYGYATDQIVEYAKEKNIDIVVGPEARGFIIGCPVAYSMGIGFAPVRKEGKLPREVIRYEYNLEYGTNVLTMHKDAIKPGQRVLITDDLLATGGTIEAAIKLVEQLGGIVVGIAFIIELKYLNGIDKIKDYDVMSLISYDE

Output: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


Instruction: What is the functional description of the protein sequence?

Input: MLEGIVRESIGRKAAKALKRDGYLIANIYGKGLENINAAFKVNEFIKEVRKKTTLIFDVKVGSQTLSVVVVDYQKDPVTAELKHVDLKVAQKGVISKYMVPVKITGTAIGLKNKGVLIQSKRRLKVKCAAENLPNFFELDVSKLDVGDALLVRDIVVPAGVTMIDADRVAVVGVEKAR

Output: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARVKRGVTARARHKKVVALAKGYRGRSKNCYRAALQRLEKALVYAYRDRRNRKRDFRRLWIVRINAAARQWGIKYSQLMKGMALCGIELNRKMLAEMAVNDKAAFEKVVSAVAGTCGYACAVNQQDK

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism.


Instruction: What is the functional description of the protein sequence?

Output: Probable transporter.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MNKTPMTTRGAEKLREELNHLKTVARPRVIEAIAEARAHGDLKENAEYQAAREQQGFIEGRIKEIEAKLANAQIIDVTRLNPGGKVVFGATAEIEDLASGEVVTYQIVGEDEAEIKEGRISVTSPIARALIGKQEGDVATVQAPGGTREYEIVSVRYV

Output: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Activates expression of the rhaBAD and rhaT operons.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of L-arabinose to L-ribulose.


Instruction: Predict the general functional description of the protein sequence.

Input: MRLNTLSPAEGAKHAPKRVGRGIGSGLGKTAGRGHKGQNSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAMITAEVRLSELALVEGDVIDLNTLKAANVVGIQMEFVKVILSGEVNRAVTLRGLRVTKGARAAIEAAGGKIEE

Output: Binds to the 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Proton-coupled antiporter flippase that catalyzes the translocation, from the inner to the outer leaflet of the cell membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors lipoteichoic acids (LTA) to the cell membrane.


Instruction: What is the functional description of the protein sequence?

Input: MDSNTVSSFQDILLRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLGQKFEEIRWLIEEVRHRLKTTENSFEQITFMQALQLLFEVEQEIRTFSFQLI

Output: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).


Instruction: What is the functional description of the protein sequence?

Input: MAVIADPETAQGFRLAGLEGYGASSAEEAQSLLETLVERGGYALVAVDEALLSDPERAVERLMRGRDLPVLLPIAGLKEAFQGHDVEGYMRELVRKTIGFDIKL

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKKDIHPKYEETTVTCACGNVINTRSTVKDIKVEICSQCHPFFTGKQKLVDTAGRIDRFKKRYNIKD

Output: Binds the 23S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MKLILTADVDHLGAVGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADDIRRARETKAVRDLDHANEFKTAIEALGPVTLPVKTAGDSGKLFGSVTAGDVVAAIKKAGGPNLDKRIVRLPKAHIKALGTHPVAVHLHPEVDVEVPLEVVPQS

Output: Binds to the 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MEALVYTFLLVSTLGIIFFAIFFREPPRISTKKMK

Output: Seems to play a role in the dimerization of PSII.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MDDSIDEEVISGGSTITVEFSGGAETLFGGVKEHIVPLDGSKIVLLEEMLRWLRDHLLTGDAGLFLQENTVRPGILVMINDTDWDLMGETEYILQPGDHILFISTLHGG

Output: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.


Instruction: Predict the functional description of the protein sequence below.

Input: MIASKFKIGQQVRHKLLGYLGVVIDIDPEYSLEKPTLDEVTKNDSLRKFPWYHVVMEDDEGKPIHTYLAEIQLGYEDTVIHPEQSTLDDLAESIRLQLQTPRLRN

Output: Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.


Instruction: Predict the general functional description of the protein sequence.

Input: MNWRSERIWIELITGSRKTSNFCWACILFLGSLGFLLVGTSSYLGRNLISLFPSQQIIFFPQGIVMSFYGIAGLFISSYLWCTISWNVGSGYDRFDRKEGIVCIFRWGFPGINRRIFLRFLMRDIQSIRMEVKGGLYSRRVLYMEIRGQGAIPLTRTDENFTPREIEQKAAELAYFLRVPIELK

Output: Seems to be required for the assembly of the photosystem I complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.


Instruction: What is the functional description of the protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: What is the functional description of the protein sequence?

Input: MFNDIGPLELVTLVVLAVLVFGPDKLPKMIQDVTRTIRKIREFSESAKQDIREELGPEFKDFEFEDLNPKTFIRKQLDNDELGLKEIRNGFDLKKEMAEVTDAVHGRESETSASSSSANGSAGGTVDMTKKREQLEADERPPFDADAT

Output: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


Instruction: Predict the general functional description of the protein sequence.

Input: MSTGLFDFNGTLPVMGLQVVLLSWLLEQILYSPIQGVIQKRQNKIQQELQLAADQLQKAQQLTQEYQTQLQKAREKARERIRQVQQEAQTMMEDQLKQAQQQMTQLFNEAMQQLEQQKQQALMNLSNQVDEVAKFILSKLMKQ

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Predict the general functional description of the protein sequence.

Input: MPRKGYIGKRDVLPDPMYNSKVLTKLINSLMYDGKKGLAQKICYDAFDVIQNKTGKEPMEVFEEAMNNVMPLLEVKARRIGGATYQVPLEVRPERRQTLGIRWILIAARKRGEKYMSERLAGELMDAANNLGAAVKKREETHKMAEANKAFAHYRY

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MDSFGRAPPLWPQSALPRVPGAAPSSSGLPWSRVGEIAIFTFVAVLALYLLWSWVGRDLLLVLKARRGGTTEELTFGPRERHSLPAVAVARVENPPCPSGSVEARPFTG

Output: Involved in the viral transport within, and between cells.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MACCRCDSSPGDYSGALLILFISFVFFYITSLSPQGNTYVHHFDSSSVKTQYVGISTNGDG

Output: Cell-to-cell movement function.


Instruction: Predict the functional description of the protein sequence below.

Output: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.;


Instruction: What is the functional description of the protein sequence?

Output: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Molecular chaperone. Has ATPase activity.


Instruction: Predict the functional description of the protein sequence below.

Input: MRCPKCNYLKSSVVDSRQAEEGNTIRRRRECENCHTRFTTFERIEELPLLVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSSAIEKVVNDIEQKIRSDYDSEVSSVVIGNLVMDELAELDEITYVRFASVYRSFKDVDEIEALLQQITNRVRSKKKRKADETN

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: What is the functional description of the protein sequence?

Output: Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Involved in the high-affinity zinc uptake transport system.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MLKRSLLFLTVLLLLFSFSSITNEVSASSSFDKGKYKKGDDASYFEPTGPYLMVNVTGVDGKGNELLSPHYVEFPIKPGTTLTKEKIEYYVEWALDATAYKEFRVVELDPSAKIEVTYYDKNKKKEETKSFPITEKGFVVPDLSEHIKNPGFNLITKVIIEKK

Output: Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1:1 complex with plasmin, which in turn activates other plasminogen molecules (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of the elfADCG fimbrial operon, which could be required for adherence to host epithelial cells. Could be required for the biogenesis of the ElfA fimbriae.


Instruction: What is the functional description of the protein sequence?

Input: MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH

Output: Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons.


Instruction: Predict the general functional description of the protein sequence.

Input: MRKFLKSAIEYLAKDLDLDKELLEQIQYVVIVLTFEFIKCISVILIAGILGYFKESLIVILSMCFIKPFIGGYHEDSQLKCFIATLIITTSIIMLVTFNKLNLFSIVILNLFSIFSIYNKAPVIDSRFPLTKEHLIKKNKILSVTNSSILFLITLIFFKISWISQTITWTLLIQTLLLFNKYKREDS

Output: May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Has been proposed to be a redox modulator.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARYFRRRKFCRFTAEGVVEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARCIKRARYLSLLPYTDRHQ

Output: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


Instruction: What is the functional description of the protein sequence?

Output: H(+)-stimulated, divalent metal cation uptake system.


Instruction: Predict the general functional description of the protein sequence.

Output: Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MNKYETLFILNPSLDEEGINTNVEKFKSVITNGGGEVENVDLWGKRKLAYEIDKVNEGIYVLVNFQSDAQLPKELDRVFRISDSIIRHLIISLEK

Output: Binds together with S18 to 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAISQERKNEIIKEYRVHETDTGSPEVQIAVLTAEINAVNEHLRTHKKDHHSRRGLLKMVGRRRHLLNYLRSKDIQRYRELIKSLGIRR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: Predict the general functional description of the protein sequence.

Input: MRVIDASGAIYGRLSAYVAKRLLEGEEITIVNASKAVITGNKEFIIEKFKERLDIGSVRKGPYYPKTPENILRRSIGDMLPKKITKGKEALARCRVYRNTPPDIEKEKVEKVDGVVTDKVSGIITLGDLSKELGGY

Output: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


Instruction: Predict the functional description of the protein sequence below.

Output: Acts with RNA polymerase to initiate transcription from late gene promoters.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: What is the functional description of the protein sequence?

Input: MKKEHRIKRSDEFSRVFNEGFSVANRQFVIYVLPKEGQDFFRVGLSVSKKIGNAVTRNRVKRLIRTFFQEHEQAISGERDYVIIARKPAADMTYEQVKGSLWHVCKKAKIIQPKVRAHK

Output: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MELNAFTILQIAVFIAVGYHANTHSPVAGSEVQKLTSDPNDDIDVSYCGMNCTVVNGKSDECSENCKCLHEGDDPKGICVAITYFGDWGDPNDDPKINEATPQTQIFEKKRK

Output: Salivary chemokine-binding protein which binds to host chemokine CXCL8.


Instruction: Predict the general functional description of the protein sequence.

Output: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSKTVEPACLVPVGKVTRTHGIRGALKIFPYGESLAAQAAGERFFLRSKNGGYCTLTLIGLRAQGRMLVCGFEEIKDVNGAQPFVGEEIFLPEDRLPPVSEGEYYHYRLIGLDIVTLDGESLGVLRKIIETGGNDVYVAEREGREILIPAIEDVIREIDLERKRMVVDLPEGLVDA

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Specifically methylates the N7 position of a guanine in 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: What is the functional description of the protein sequence?

Input: MFGKGGMGNLMKQAQMMQEKMAKMQEEIARMEVTGESGAGLVKVTMTGTHNVRKVEIDPSLLEDDKELLEDLVAAACNDAARRVEENQKTKMAEVTGGMQLPPGMKMPF

Output: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


Instruction: Can you provide the functional description of the following protein sequence?

Output: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.


Instruction: Predict the general functional description of the protein sequence.

Input: MEVILLEKVANLGSLGDKVKVKAGYGRNFLLPYGKAVPATEANVKAFEERRAELEKAAAEKLAAAQARAEALEGASFTITSKAGEEGKLFGSIGVRDIADAVSTGGTEVEKSEVRLPEGPIRVTGEYDIELQLHTDVEVTIKLAVVAE

Output: Binds to the 23S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.


Instruction: What is the functional description of the protein sequence?

Input: MIQTESRLEVADNTGAREVMCIKVLGGSKRRYASIGDIIKVSVKEATPRGRVKKGEIYNAVVVRTAKGVRRQDGSLIKFDGNAAVLLNNKLEPIGTRIFGPVTRELRSERFMKIVSLAPEVL

Output: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MIDIGLSKMALIGAVALIVIGPEKLPRVARTVGTLLGKAQRYVADVKAEVNRSMELDELKKMKDTVESAAREVHDSIQTSASAFEKDWAEAIDSAAPLPGSTATVPAPEYKHPGKRWRLKRSALPQWYKARSGVRSKALSGAARVARYRPGKSR

Output: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.


Instruction: What is the functional description of the protein sequence?

Output: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


Instruction: Predict the functional description of the protein sequence below.

Output: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MSRDYKGKKIVIYPQYIDSSIPRSRGRRIPRNIAIPKPRIEEIIEAAEELGLNPKYEESAYPKHWWIKGRIVVDKVGSKLNTLKLIAQKIKDLRK

Output: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVMLDLLSNALTAIKNAEAMGKRQVVIWPVNKLIYYTLRVLQRYGYVGEIEYIDDGRGGKYVVQLLGKINDIGAIRPRFPVKYREIVEWEQKYLPARQIGILVISTSQGVMSHLEAKEKKIGGVLLAYVY

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARRRKYEGLNPFVAAGLIKFSEEGELEKIKLSPKAAIAISLAIIAAILALNLLLPPP

Output: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAEENQVAAPEEAQTPFELQIQRIYIKDVSFEAPNLPTIFHQEWKPQLGFELDTETKQLDEDLYEVVLHINVSTTLEDSGDTAFICEVKQAGVFTIKGIEGIQLAHCLASQCPNVLYPYARELISSLVNRGTFPALNLSPVNFDALFMDYLQRQEAEQNAEAPAVN

Output: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.


Instruction: Predict the functional description of the protein sequence below.

Input: MSLTNEQLIEAIASKSVSEIVELIAAMEEKFGVSAAAAVAAAPAAGAAAAEEKTEFDVILAEAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGISKPEAEALKKELEEAGAKVEIK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: What is the functional description of the protein sequence?

Output: Displays ATPase and GTPase activities.