Instruction: Predict the functional description of the protein sequence below.

Input: MSVTIDDVTYIAELARLRFSDDEALKMTDELNTILHYVDTLNEVDTEGVLPLSNIHDQKNVLRADEEHEPIANAAALSNAPDSQDRFFRVPKVLG

Output: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).


Protein Function Description

Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MIDDDGYRPNVGIVICNRQGEVLWARRYGQHSWQFPQGGINPGETPEQAMYRELFEEVGLNKKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQRWFLLQLMCNEAEINMQRSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFAATVMPVQEVAPPRVPPAYRRKRG

Output: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MITGIQITKAANDDLLNSFWLLDSEKGEARCVVAKAGFAEDQIVPVNKLGEIEYREIPMEIQPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTASL

Output: Acts as a radical domain for damaged PFL and possibly other radical proteins.


Instruction: What is the functional description of the protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.


Instruction: Predict the general functional description of the protein sequence.

Input: MEKFTIHTGTAVPLRLSNVDTDQIIPAVHLKRVTRTGFADALFSSWREDQAFVLNDESYSGASILVAGPEFGTGSSREHAVWALRDWGFRVVIAPRFGDIFRGNALKGGLLPVELELKAIEEIWGRIEADPSTSITVDLAARQVQVGGVNWGFPLDEFSRWRLMEGLDDIGLTLRHEPLIGAFEASRQPFLPTIA

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: What is the functional description of the protein sequence?

Input: MSERDKLYHVLLDRLYAKLPKKDLASETQTLPTLSIINVGNTTIIRNFSEYCDRIRREDKICMRYLLKELAAAGSISENGQLMIQGKFSNAIVNTFMDRFLKTYVQCSTCKSLDTVLVKDKKIWYIQCLACGAKNPVKPL

Output: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MHMRLVVIAIGRLKQGPERQLAERYRERFDDIGRKLGFRGLDIHEIPESRARDAATRMAEEAAAIAAAIPDNSMLVCLDERGHNIDSATFAGHIGRWRDEGVAATAFVIGGADGLSPELRRKAKLGVAFGAATWPHQIVRVLLLEQIYRTATILAGHPYHRA

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MSILSLVTAPDPILKKVSSPVDTVNDSIRQLIDDMLETMYHNHGVGLAAPQVAVSKRIIVLDLSKVDIEEDNITNSEYKYPLFMVNPIVKAISNQTVTAKEGCLSLPKQAIEVSRYHEIQVTYLDYYNKLKTLNAAGWLARAIQHEVDHLDGILLVDYLSNLKKEATLNTLSKIKDAAYDK

Output: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MGASPVQLLIVLFIAVLVFGGKRLRTLGSDVGAAIKGFKEAMKEEPTEPEKLEQQPPVIEVVATQKEKTKG

Output: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.


Instruction: Predict the general functional description of the protein sequence.

Input: MIQGIQITKAANDDLLNSIWLLDSEKNEARCVAALKGFEADQVVSINDLGQFESREVAIEAAPRIEGGQHLNVNVLKRETLEDAVAHPEKYPQLTIRVSGYAVRFNSLTAEQQRDVIARTFTESL

Output: Acts as a radical domain for damaged PFL and possibly other radical proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.


Instruction: What is the functional description of the protein sequence?

Input: MIYIDNRQNKIKVNEELENKIKEIIDYALKEEKVNIDYEISVVFIDNNSIKEINKDYRNIDKATDVLSFPMLDYEDGEVFKDIYLNYEFDESDLDEGNLVLGDIALSLEKAEEQSKEFGHSFLRETCYLTIHSVLHLLGYDHMEEDEKVIMRQREEEILKSFNLHR

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MFKKVDKKASREKRHLRVRKKVFGTAERPRLSVFKSEKNIYAQVIDDINGVTLVAASSLEKDFAAKGGNKEGAKLVGELVAKKAIEKGIDVVVFDRGGYIYHGRIQELAQAAREAGLKF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: What is the functional description of the protein sequence?

Input: MKNVTDSFVYLVGHCPFAGSFAFNTDILATNPINLSIVLGVLIFFGKGVLNDLLDNRKQRILSTIQNSEELRKKTIEQLERARDRLRKVEIEADEYRINGYSEIEREKTNLINATYDSLERLENYKNETLHFEQQRAINKVRQRVFQEALQGALGTLNSCLNSDLHFRTISANIGILGAMEEITD

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MALDSAKKQEIISKFAEHEGDTGSPAVQIALLSERISYLTEHLKEHKKDHSSRLGLLKLVGQRKRLLNYLKRKDYEKYTQVIKELGIRG

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.;


Instruction: What is the functional description of the protein sequence?

Input: MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSKQSLSSFLFTRLNFYLIDLFRQQNQLKDVILCENNSPTLTEQPTYFNEHDLRLQDIFKLLNQRERLWLKLYLEGYKQFEIAEIMSLSLSTIKLIKMSVKRKCQHNFN

Output: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: May act as a negative regulator of salt tolerance.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


Instruction: What is the functional description of the protein sequence?

Input: MTKETQSFEEMMQELEQIVQKLDNETVSLEESLDLYQRGMKLSAACDTTLKNAEKKVNDLIKEEAEDVKNDESTDE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the general functional description of the protein sequence.

Input: MSEVETTNDQTPAPKRKDKKPSRSQLRSASRRLALQAVYQWQMNKTAVSEIETQFVIDQDRDMDSCDKVYFRELLQGVTASAKKLDTLFEELLDRPLSELDPIELAVMRIGSYELSQRLDVPYRVAINESVELAKGFGATESHKYVNGILDKLAQRVRREEIAARREANKESNK

Output: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


Instruction: What is the functional description of the protein sequence?

Output: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MNWAAAVCWALLLAATFLCDGSAAKGGRGGARGSARGGRGAARVRVRPAPRYAGSSVRAAAGAAAGAAAAAGVAAGLAAGSSWRRAAGPAELGLEDAEDGAPGSNGTGRGVYSYWAWTSGAGPTGHRHLCPLLGGALGALRLLRP

Output: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MTASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYSLVSFDGH

Output: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


Instruction: Predict the functional description of the protein sequence below.

Input: MSSDGTPGRKRSAKVRSSVSGLEIEVLREAGDWESSTDETVRRAAEHAYAVARGDESAELCIVLGDDALVAKLNKAYRGKEGPTNVLSFPAAEMPDTGAPEAVFGGATPLLGDVVLARETIAREALDQNKKFADHLSHLTVHGVLHLLGHDHMEDVDADEMEALERDILEDLGIADPYGADHPGQ

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MQSEPMTLYGYEKITAELKDLKMVQRPNIVRDIDIARSHGDLKENSEYHAAREKQAFIENRIAEISDIVSRAKVIDPSTYEHDKVKFGSTVTIMDVETELEKTYVIVGISESDISKGYININTPLARQLLGKVEGDDVILNLPNGVSEIEIVSVEYKPINFN

Output: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQVILKEKVENLGVLGDIVNVKPGYARNFLIPFGKAVQATQANIKAFEAQKAELEKAEKARFEAAVAVADAIKDKVYTIAAQAGEGGKLFGSVGIAEVAEAVSNQSGKKIEKSQVRMPEGVIRSIGEFELTVHVYTDVDADIKVNVVAAEA

Output: Binds to the 23S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MARKALMVKAQRPQKYTVRAYNRCKICGRSRAYMRKFGMCRICFREHALRGLIPGVTKSSW

Output: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES

Output: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Input: MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYTGRQKFASADGRVDRFNKKYGLK

Output: Binds the 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Endoribonuclease that initiates mRNA decay.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


Instruction: What is the functional description of the protein sequence?

Output: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Oxidative deamination of D-amino acids.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQIWHMEPFPCGDRRLPHHVFPPKKITTTQLGALAGVQYYKVDLEDTASMKKRLSAVKTEKNVTFTDVFTVSETMLDFDDKMEQFYEAQTQKEDVISLVVEGTCYYDVEPEDDSWIRVQLEKGDLIVIPKGLSHRFTTTPQNFVKIQRFFSRKVEGTQG

Output: Probable inactive acireductone dioxygenase.


Instruction: Predict the general functional description of the protein sequence.

Input: MILMKDIVRDGDPVLRQVAKPLTFPLSDHYKQLAEDMMEYLVNSQDPKIAEKHQLRAGVGLAAPQVGEGVQMAALLVPDDKGEIIFKEVYVNPEIVSESVRQACLSEGEGCLSVDKVINGYVPRPDKLTIHYYTVDGEEKTIRLKDYPAIVSSHEIDHLNGHLFYDRINKKEPFALKEDTVVIS

Output: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


Instruction: Predict the functional description of the protein sequence below.

Input: MNTLTIFGIAVALAMDAFAVSIAAGVFLRSIGLRHYFRLAWHFGLFQALMPIVGWYAGLSVRGLIERYDHWIAFFLLAFVSFNMIRESFDAGENHTKADPTRGLRLVLLSIATSIDALAVGLSLSVLNVSVWMPATVIGITAAVFTVGGLMMGSRAGDIPWLRRYADRVGAGVLLFIGLRILYAHGVFY

Output: Probably functions as a manganese efflux pump.


Instruction: What is the functional description of the protein sequence?

Output: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.


Instruction: What is the functional description of the protein sequence?

Output: Methylates ribosomal protein L11.


Instruction: What is the functional description of the protein sequence?

Input: MNKIRKGDQIIVLTGRDKGKQGVVSARKDDSHLLIDGINMVKKHVKPNPMKGTTGGIVEKAMPIHQSNVAIFNAATGKADRVGIKVQADGTRVRVFKSSGAEIKAA

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Predict the general functional description of the protein sequence.

Output: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.


Instruction: What is the functional description of the protein sequence?

Input: MSNVPTELKYALSHEWVRADGDGVYSVGITEHAQELLGDMVFVDLPEVGSDVSAGSDCAVAESVKAASDIYAPISGEIVAVNTELENSPELVNSAPYTDGWLFSIKAADESELDNLLDADAYLAAIEE

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: What is the functional description of the protein sequence?

Input: MAKKNAKNSKNSSASIARNKRATFDYKFEEKLEAGLSLMGWEVKSIRMGKVNLSESYVFLREGEAYLFGCTIAPLNTASSHVVCDPLRSRKLLLKRKELDKLQGLVDRKGYSIVPISMYWQKGAWVKIEIGLGKGKKEHDKRDDTKDREWQIEKARTIKKAVQQ

Output: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


Instruction: Predict the functional description of the protein sequence below.

Input: MVEALLSGIVPGLIPITLAGSFVIAYLQYRRGDQLDL

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA

Output: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: What is the functional description of the protein sequence?

Input: MLRFTDEHEWLRLDGDVATVGITAHAAEQLGDLVFVELPKVGVKLTKGEAAAVVESVKAASDVYAPLSGEVTEVNEAALSDPASVGADPQGAGWLYRLKLDDVSAMDALMDEAAYADFAK

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Endoribonuclease that initiates mRNA decay.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSDNTEKKTLRTVEGRVVSNKMDKTVTVLVERQVKHALYGKYIKRSTKLHAHDADNACKEGDVVRVTEIAPMSKTKNWRVVEVITRAAE

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPIIKSAIERVRTSEKAEARNASQLSQMRTAIKKFDKAKLAGADNLDDLYKAAISAIDRAHSKGLIKANKAARDKSRLSARYAK

Output: Binds directly to 16S ribosomal RNA.


Instruction: What is the functional description of the protein sequence?

Input: MIVTEILGNIHEDSGRELVAGRHVEKVVLPSAELVKRIQRLRTDHDRQIGLRLPAGAPDLRDGDVVAVEDAAPSGAGHGDGEQDGTGAPGRGNAVVIQVLPTDVLVIGARSVVEMAFVAHSLGNRHLQAQFFDADSEYGAEVMVVQYDHTVQDFLDHHGVPYSRQERVMPVPFRHAEHTH

Output: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.


Instruction: What is the functional description of the protein sequence?

Input: MDDVNSIVLAAGQAAEEGGTNNFLVPNGTFFFVLAIFLVVLAVIGTFVVPPILKVLRERDAMVAKTLADNKKSAEQFAAAQADYEKAMAEARVQASSYRDNARAEGRKVVEDARAHAEQEVASTLQQANEQLKRERDAVELDLRANVGAMSATLANRIVGVDVTTPAAAG

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Predict the general functional description of the protein sequence.

Input: MARIAGVNIPTNKRVIIALQYIHGIGPKKAEEICEKVSIPPERRVVDLTDAEVLQIRETIDRDYIVEGDLRREVAINIKRLMDLGCYRGLRHRRQLPVRGQRTHTNARTRKGKAKPIAGKKK

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: What is the functional description of the protein sequence?

Output: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MNKIRKGDRVIVRTGKDKGKQGTVLAVLAEHVTVEGVNVAKKHVRPNPMLGTTGGVVDKIMPIHISNVALVDANGKPSRVGIKVEGGVKTRVLKTTGAAVGA

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Predict the general functional description of the protein sequence.

Output: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


Instruction: Predict the general functional description of the protein sequence.

Output: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.


Instruction: What is the functional description of the protein sequence?

Output: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.


Instruction: Predict the functional description of the protein sequence below.

Input: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ

Output: Involved in the binding of tRNA to the ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSEKLIVKCPTCRTEVIWDESSPYRPFCCKRCQLIDLGEWAAEEKRIPSQSESNDSDEWSEMPEQDPKPFN

Output: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MKVILLERLEGWGGLGDVVDVKDGYARNFLLPRQKALRANGANLKVFEAQRAEIEARNAKAKEAAGKAGEKLDGTQYVLIRQAGESGQLYGSVSGRDVADAVNAEGGKVERSMVVLDKPIKTLGMHEVKIRLHSEVAVTVTLNIARSQDEADRQARGENVIASQFEDERMAAEQAAADLLEGGAGQQASEYTEAQA

Output: Binds to the 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLIYLRTLAFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism.


Instruction: Predict the functional description of the protein sequence below.

Input: MSKQDEVIVVGKFGASYGIRGWLKVVSFTDQPESIFDYKPWLIQVKGEWVEFSVESWKRHKGLVCKLKGLDVREEAQTYTNLEIAVKADVLPELSEDEFYWRELFGMEVVTTKGYALGVVDDIFETGSNDVLVVKANLKDAFGKKERLIPFIDEQVIKLIDREAQRIEVDWDPGF

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MLVPKRVKHRREFRGKMRGEAKGGKEVSFGEYGLQATTSHWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKVMFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE

Output: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.


Instruction: What is the functional description of the protein sequence?

Output: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


Instruction: Predict the general functional description of the protein sequence.

Output: Proton-dependent permease that transports di- and tripeptides.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAQTTNDIKNGSVLNLDGQLWTVMKFQHVKPGKGPAFVRTTIKNVLSGKIVDKTFNAGMKMEFETVDNRTLQYSYEDGDNFVFMDMTTYDQIMVPKTLLGDKAKFLLEGTDCLVSFHDGTPLSVDLPGSVVLTITHTEPGLQGNRSNAGTKPATVETGAEIQVPLFINEGDRVKINTEDGSYTGRENN

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.


Instruction: What is the functional description of the protein sequence?

Input: MSKSDLNLLVENIKFEHLNVFYDFVVSVLNALSISDFELSVILCDNAYIQELNNKFRNKNEPTDVLSFNYNEHNELNEDLVDGINYKIQGDLVISFEYLKFSAQEFNVEIYEELQRVTIHGILHLMGYKHETNDFQKEGMLILQENILKENKRVF

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MHCPFCAYADTRVVDSRLADDGGSVRRRRECPQCGQRFTTFERAELALPVVVKTDGRRESFNEEKLQRGLTRALSKRPVATARVDAAVRMIQRRIRERGEREIPARLIGELVMEALRDLDPVAYVRFASVYRRFEDVDAFSVEIARMKEAEVPDGGDDLNRGD

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).


Instruction: Predict the functional description of the protein sequence below.

Input: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRNYVKKLLKHPRQ

Output: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.


Instruction: What is the functional description of the protein sequence?

Output: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.


Instruction: What is the functional description of the protein sequence?

Input: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEDRSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS

Output: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN

Output: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSDVAEKVKKIIVDQLGVSADEVKPEASFVEDLGADSLDLTELIMAMEEEFEVEIADEDAQKILKVQDAIAYIEEKK

Output: Carrier of the growing fatty acid chain in fatty acid biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.


Instruction: What is the functional description of the protein sequence?

Output: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


Instruction: Predict the functional description of the protein sequence below.

Input: MHVKTGDEVLVIAGKDKGRRGKIKRALPAVNRVVVEGINIVKRHQKPRGPGRPGGIIEMEAPLHASNVMLICPSCGRASRTGKRFLEETDHKGRPRKVRYCKACDAVIDK

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: VDPAQVSGSWRTAAIASD

Output: Binds the chemical odorant, 2-isobutyl-3-methoxypyrazine.


Instruction: Predict the general functional description of the protein sequence.

Input: IIGDTINGAITTADNIAGKIGII

Output: May act as an antimicrobial peptide.


Instruction: What is the functional description of the protein sequence?

Output: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.


Instruction: Predict the functional description of the protein sequence below.

Output: Acts as a chaperone.


Instruction: Predict the general functional description of the protein sequence.

Input: MVDHARAARMAKRIQTIVASAIERQIKDRRLELVTITDARVTGDLHDATVFYTVRGTDIGTEPDYDQAAEALTRAKGQLRKIVGDELSVRFTPTLSFELDTVPEASAHMEELLARARARDAELAKLKEGAQPAGDANPYKTSDEEED

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MARLAGVDLPRNKRMEVALTYIYGIGPTSAKQLLEKTEISPDLRTDALTDDQVAKLRDAIEAEYTVEGDLRRQVQADIRRKIEIGSYQGLRHRRGLPVRGQRTKTNARTRKGPKKTIAGKKK

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Predict the general functional description of the protein sequence.

Output: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.


Instruction: What is the functional description of the protein sequence?

Output: Cysteine dioxygenase involved in sulfite formation from cysteine. Required for keratin degradation and plays an important role in filamentous growth and virulence.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKTAIFTVVLALAVFAVLCLVVSTHAERHSKTDMEDSPMIQERKGLPPGKPCYGATQKIPCCGVCSHNNCT

Output: Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells. Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: May be involved in a process influencing telomere capping.


Instruction: Predict the general functional description of the protein sequence.

Output: Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: RFKKIRRLGALPGLTSKRPRSGSDLKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPRDIITTKDKERSKVLIQNYIASSPHEELPNHLTIDPLQYKGLVNQIIDSKWVGLKIN

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Predict the functional description of the protein sequence below.

Input: MDSNTVSSFQDILMRMSKMQLGASSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI

Output: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MIEVGEYKVKEGLYYTKDHEWAQVLEDGTVLVGITDYAQKELGDLAYVELPEVGKEVSKGDVLCEVESVKAVSEVYAPVSGEVIEVNEELSDSPEKINEDPYGAWIAKIKPKNLEEELKELMDAEKYAEYLKTL

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: RLFDQFFGEGMFDHDLLPFTSPTISPFYRQSLFRNFLDSSNSGISEVRSDRDKFTVHWDVKHFSPDELSVKVIDDFVEIQGKHGERQDDHGYISREFHRRYRLPSTVDQSAITCSLSADGLLTLSGPNPAGGPNGRSDRSIPVCR

Output: Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.


Instruction: What is the functional description of the protein sequence?

Output: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: ADAPAGFTLCKACHSVEAGKNGVGPSLAGVYGRKAGTISGFKFSDPHIKSGLTWDEPTLTKYLADPKTVIPGNKMVFAGLKNPDDVKAVIEYLKTLK

Output: Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Together with two further proteins McbF and McbG this protein causes immunity to the peptide antibiotic microcin B17 (MccB17), which inhibits DNA replication in enterobacteriaceae. Immunity is determined by two different mechanisms. McbE is involved in the production of extracellular MccB17 and, in a complex with McbF it also serves as 'pump' for the export of active MccB17 from the cytoplasm to the periplasmic space.


Instruction: What is the functional description of the protein sequence?

Output: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MHLLPELASHHAVSIPELLVSRDERQARQHVWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRLWDIDVLTPEGEILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDACNVN

Output: Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.


Instruction: Predict the functional description of the protein sequence below.

Input: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA

Output: Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA (By similarity).;


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MNKSQLIDKIAAGADISKAAAGRALDAIIASVTESLKEGDDVALVGFGTFAVKERAARTGRNPQTGKEITIAAAKVPSFRAGKALKDAVN

Output: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


Instruction: Predict the functional description of the protein sequence below.

Input: MLDKIDRKLLALLQQDCTLSLQALAEAVNLTTTPCWKRLKRLEDDGILIGKVALLDPEKIGLGLTAFVLIKTQHHSSEWYCRFVTVVTEMPEVLGFWRMAGEYDYLMRVQVADMKRYDEFYKRLVNSVPGLSDVTSSFAMEQIKYTTSLPIE

Output: Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L-cysteine; activates transcription from the dlsT(yhaO)-yhaM operon.


Instruction: Predict the general functional description of the protein sequence.

Input: MSIDRTSPLKPVSTVQPRETTDAPVTNSRAAKTTASTSTSVTLSDAQAKLMQPGSSDINLERVEALKLAIRNGELKMDTGKIADALINEAQQDLQSN

Output: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex PstSACB involved in phosphate import.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: ADVPGNYPLNTNGNMYYCTILGENEFCRKVCKVHGVKYGYCFNSHCWCEYLEAKDVSVWNAAKNYCKNPVGK

Output: Binds to sodium channels (Nav) and affects the channel activation process.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Major core structural protein.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein ORF2 is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSANNMRLLCLLLACYISAIVAHRPSYRSSGSDRYVDVVRASETAEAQAAALTNAAGAAASAAKLDGADWYALNRYGWEQGRPLLAKPYGPLDNLYAAALPPRSFVAEIDPVFKKSHYGGAYGGKSVTLNTGAKVAVAALN

Output: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.


Instruction: Predict the general functional description of the protein sequence.

Output: May serve as anchor for the fimbriae in the outer membrane.


Instruction: Predict the functional description of the protein sequence below.

Input: MTKIGLFYGTQTGNTETIAELIQKEMGGDSVVDMMDISQADVDDFRQYSCLIIGCPTWNVGELQSDWEGFYDQLDEIDFNGKKVAYFGAGDQVGYADNFQDAMGILEEKISGLGGKTVGFWPTAGYDFDESKAVKNGKFVGLALDEDNQPELTELRVKTWVSEIKPILQS

Output: Low-potential electron donor to a number of redox enzymes.


Instruction: Predict the functional description of the protein sequence below.

Output: Essential for virulence of baculovirus occlusion bodies for insect larvae.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for the transposition of the insertion element.


Instruction: What is the functional description of the protein sequence?

Output: dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: F-box protein that manipulates the host DNA damage response (DRR) in order to promote viral multiplication. Acts as a substrate recognition component of SKP1/Cullin/F-box (SCF) complexes for targeted protein polyubiquitination.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: ELNPSLVISLSXGL

Output: Not yet known.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in lipopolysaccharide biosynthesis and pathogenicity.


Instruction: Predict the functional description of the protein sequence below.

Input: MTEQTIDNILPASKNNVKQWYVVHTASGAEKRIKEDILRKIAKQKMTDFFEDILIPVFGVSEVKRGKNVKVEKKLMPSYILIKMNMTDKSWHLVKNIPGVTGFLGSKIVPKALTESEIQNIFNNLEAEAKVAKNSKLYEVGEIVTVTDGPFETFMGTVEAIDKARNRLKVSVSIFGKATPIELNFNQVKKSD

Output: Participates in transcription elongation, termination and antitermination.


Instruction: What is the functional description of the protein sequence?

Output: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine.


Instruction: Can you provide the functional description of the following protein sequence?

Input: SPTISITAPIDVLRKTWEQERARKQMVKNREFLNSLN

Output: Stimulates fluid secretion by the Malpighian tubules. Increases cyclic AMP production.


Instruction: Predict the functional description of the protein sequence below.

Input: MLQKKKYQKKSSKIIINKKAYYNYFIEKVFQSGLVLEGWEIKSIRSGKVNISESYIINDRNEMYLCNCLIEPLQMSSNRFSCDPTRKKKLLLHKNEIDFLSLKKKNTGYTMVSLSLFWKKSWCKLEFGLAKGKTAQDKRINLKKREWEQEKLKILKKTKETY

Output: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.


Instruction: What is the functional description of the protein sequence?

Input: MSRRGTAEKKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDITVKARRVGGSTHQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.


Instruction: What is the functional description of the protein sequence?

Input: MAQRERNREERGREERDSEFVDKLVHINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAIRKATEAAKRDMIFVPLRSGRTLHHDVEGRHGAGKVLLRAAPAGKGIIAGGPMRAVFETLGVQDVVAKSLGSSNPYNMVRATFDALKHQMHPKDIAAQRGIKYSTLQARRHDVVGSEE

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the general functional description of the protein sequence.

Input: MVKSARQGAGGFWRDFKDFILRGNVVDLAVAVVIGGAFTSIVNAFVAWLMAVLLQPVLDQAGVSQLQDLPLGLGELVIAIINFLIIAFVIFLIIKAIEKMQRKKAVEEEIVAEAQPDPVLEAQTNLTDSINRLITTLENQQSSSQ

Output: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.


Instruction: Predict the general functional description of the protein sequence.

Input: YTAKQCLQAIGSCGIAGTGAGAAGGPAGAFVGAXVVXI

Output: Bacteriocin active against Listeria monocytogenes, Pediococcus, Enterococcus, Lactobacilli and Bacilli.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: ARAVGIDLGTTNXVXAV

Output: Acts as a chaperone.


Instruction: Predict the functional description of the protein sequence below.

Input: MVEMRMKKCPKCGLYTLKEICPKCGEKTVIPKPPKFSLEDRWGKYRRMLKRALKNKNKAE

Output: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: AGLPPEEKPKLCDAACE

Output: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: GSSGLIPFPRV

Output: Mediates visceral muscle contractile activity (myotropic activity).


Instruction: Predict the general functional description of the protein sequence.

Input: MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR

Output: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.


Instruction: Predict the general functional description of the protein sequence.

Output: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MFEYLKGIVAKIDPAYVVLDVNGIGYKILCPTPYSYQENQPATIYVEQVVRDTGITLYGFLSLEDKELFLKLLSVSGIGPKSAVAIMAAEDTDSLASAIQNGEVKYLTRFPGVGKKTASQIVLDLKGKLGDYVKKSAVATDLTPSLQDALLALVALGYTQKEVDRITPKLAKLPENTADGYIKEALALLLKK

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSRSIKKGPFADASLLKKIEAQEGSEKKQVIKTWSRRSTIFPSFVGFTIAVYDGRKHVPVYITEDMVGHKLGEFVPTRTFRGHKVADKATTTVGK

Output: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.


Instruction: What is the functional description of the protein sequence?

Output: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTLNLCVLTPNRIIWDSEVKEIILPTNSGQIGVLPNHAPIATAVDIGILRIRLDDQWVTMALMGGFARIGNNEITILVNDAERGSDIDLQEAQGTLEIAEANLNKAEGKRQVIEANLALRRARTRVEAVNTIS

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).


Instruction: What is the functional description of the protein sequence?

Output: Involved in assembly of the mitochondrial F1-F0 complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endoribonuclease that initiates mRNA decay.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MNFNATLIGQTVAFIIFVWFCMKFVWPPLMNAIEARQKRIADGLADADRAVKDLELAQAKATDQLKEAKVTANEIIEQANKRKAQIVEEAKAEADAERAKIIAQGKAEIEAERNRVKEDLRKQVATLAIMGAEKILERSIDPAAHSDIVNKLVAEI

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: What is the functional description of the protein sequence?

Output: GTPase that plays an essential role in the late steps of ribosome biogenesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.


Instruction: Predict the general functional description of the protein sequence.

Output: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKFQAKSQNDAPDDGLKEKMIAVNRVTKVVKGGRILGFAALTVVGDGDGRVGMGKGKSKEVPAAVQKAMEEARRNMTKVSLKNGTIHHNVFGHWGAANVMMAPAPKGTGIIAGGPMRAVFEVMGITDIVAKSHGSSNPYNMVRATMDALNNSTTASEIAAKRGKSVEEIFG

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the general functional description of the protein sequence.

Input: MERAAKKEAVESLNGLFQTTSVAVVAHYSGLTVAQMQKLRSQMKQAGASVKVSKNRLAKIALEGTDVVAIGSLLKGPTVIATSSDPVAAPKVAVEFAKANEKFVILGGSMGKTVLNVDGVKALASLPSLDELRGKLVGLLVAPATKIAQLTTAPAAKVARVVQAYASKSEAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA.


Instruction: Predict the functional description of the protein sequence below.

Input: MGKVAAKIKVMPDSPDIDLDELQERLEQSLPEGAKINGFERDDVAFGLVALLPTVIVPDDAGGTEAVEESFGDVTGVESVAVENVGRI

Output: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTRTAIEIPENVSAEVSNLALTVEGPNGSVTRTLWYPSVTVSVDEDADADAVVIETDETDAKTSATVGTFESHVSNMIHGVTDGWSYEMEVYYAHFPMQVSVEGDEVIIENFLGEKASRRTPIRGDTNVQIDGEMVTLTGPSKEDVGQTAADIEQLTRVTDKDTRIFQDGVYITQKPQQGGA

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSKQNLIEIEGLVTESLPNAMFRVCLDNGCEVLTHISGKIRKNYIRILPGDRVKVELSPYDLTKGRITYRLRSKNTNT

Output: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


Instruction: What is the functional description of the protein sequence?

Output: Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MLQAIYNETKDLMQKSVQALNRDFSTLRSAKVSVNILDHIKVDYYGTPTALNQVGSVMSLDATTLQISPWEKNLLKEIERSIQEANIGVNPNNDGETIKLFFPPMTTEQRKLIAKDAKAMGEKAKVAVRNIRQDANNKVKKLEKDKEISEDESKKAQEQIQKITDEAIKKIDESVKNKEDAILKV

Output: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEISFDDVDKVRGLDIVIVTTANTDEESRELLKGLGMPFAK

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Output: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.


Instruction: Predict the general functional description of the protein sequence.

Input: MQRYPMTPQGHAALEAELKQLKSIDRPRITASIAEAREHGDLKENAEYHAAREQQGFCEARIRDIEAKLGGAQVIDPTTLPKDGRVIFGVSVVIENMDTEEEKQYKIVGDDEADFKAGKISVNSPIARGLIGKSEGDEARIETPKGVVEYEIMKVIYD

Output: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


Instruction: Predict the general functional description of the protein sequence.

Input: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSQLTIDRDNDKNPVVSLREIAEQTISPEDMREELVHSLQKFVEVDEPEPDTVPLIGSAGASVDADDTEVAVERMTEEELLKGLEGLAPREEQPEEDE

Output: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Efflux system for nickel and cobalt.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSMSDPIADLLTRIRNAQMVAKTTVSVPSSKVKVAIAQVLTEEGYIDSFKVNANDGKPELEIVLKYYAGRPVIERIERVSRPGLRVYRGSDAIPQVQNGLGVAIVTTPKGVMTDRKARATGVGGEVLCYVA

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Predict the general functional description of the protein sequence.

Input: MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRGVLRKFEMSRIAFREHAHKGQIPGVKKSSW

Output: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Probably phosphorylates lipids; the in vivo substrate is unknown.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


Instruction: What is the functional description of the protein sequence?

Input: MNGIKYAVFTDKSIRLLGKNQYTFNVESGSTRTEIKHWVELFFDVKVIAMNSHRLPVKGRRVRPIMGHTMHYRRMIITLQPGYSIPPLRKKKT

Output: Binds to 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MGISVHCDIVSAEQEIFSGLVEMVIAAGSEGDLGITPGHTPLLTALNPGPVRIIKQGGEEEVFFVTGGFLEVQPNMVTILSDSAQRAGDMDEAAALEAKKEAEKALANRGGDFEYSRAASQLAEAAARLRTIQQMRNKLKR

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: Predict the functional description of the protein sequence below.

Output: Minor inner capsid component. Displays NTPase and RNA 5'-triphosphatase (RTPase) activities. May function as a cofactor of polymerase VP2. Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).


Instruction: Predict the general functional description of the protein sequence.

Input: MKGLIIIGSAQVNSHTSALARYLTEHFKTHDIEAEIFDLAEKPLNQLDFSGTTPSIDEIKQNMKDLKEKAMAADFLILGTPNYHGSYSGILKNALDHLNMDYFKMKPVGLIGNSGGIVSSEPLSHLRVIVRSLLGIAVPTQIATHDSDFAKNEDGSYYLNDSEFQLRARLFVDQIVSFVNNSPYEHLK

Output: Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.


Instruction: What is the functional description of the protein sequence?

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MDIVSLTWAALMVVFTFSLSLVVWGRSGL

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: Predict the functional description of the protein sequence below.

Input: MMKMEFGKELLVYMTFLVVVTPVFVQAIKKTELIPSKWLPTVSILVGAILGALATSLDGSGSLATMIWAGALAGAGGTGLFEQFTNRAKKYGKDDK

Output: [Isoform Holin]: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (By similarity). Determines the precise timing of host cell lysis (By similarity). Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (By similarity).;


Instruction: Predict the general functional description of the protein sequence.

Output: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible oxidation of malate to oxaloacetate.


Instruction: What is the functional description of the protein sequence?

Input: MEAKAVLRNTPTSPRKMRLVAGLVRGKQVNQAKAILLNSTKAASKNVMLTLKSAVSNYTLNNPDERVSDQELFVKAIFVDGGMTLKRTLPAPMGRAYRIRKRSNHLTIVVDKVKNPVIN

Output: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).;


Instruction: Predict the general functional description of the protein sequence.

Input: METATLVAISISGLLVSFTGYALYTAFGQPSQKLRDPFEEHGD

Output: May play a role in photosystem I and II biogenesis.


Instruction: What is the functional description of the protein sequence?

Input: MSNQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRFERFTVLTSPHVNKDARDQYEIRTHKRLIDIVEPTDKTVDALMRLDLAAGVDVQISLG

Output: Involved in the binding of tRNA to the ribosomes.


Instruction: Predict the functional description of the protein sequence below.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


Instruction: Predict the general functional description of the protein sequence.

Input: MTARVCVARIGAAHGLRGEVRLWTFTEDPMSVTRYGPLSTKDGARQLEVSHARAASDHLIATLTGVTTREEAERLNGTELYVARDKLPETDEGEFYHADLIGLAAFDAAGTALGTVAAIHNFGAGDIIEIAPARGPTLMLPFTDAVVPIVDIAGGRVVIEAPAEIDGEEPNSV

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFDPTVTSYRQLLEFFFQIHDPTTEDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGLWPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRPNWKLPRKQDAGQTAAGGDR

Output: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MYATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQD

Output: Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions.


Instruction: What is the functional description of the protein sequence?

Output: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MLAKVERIDPSELELNDKLIFINRVTKVVKGGKRMGFAALVVTGDGKNHVGIGVGKAKEVPSAISKASANAKRNLSRILLNGTTVPHEIVFKYGAAQVLLKPAAPGTGIIAGGSVRAVLESTGIKDVLTKSMGCSNKANVAKATLGGLTAMRDPKATVTKRRSSLKEEATGG

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: What is the functional description of the protein sequence?

Input: MIKTILVVCIGNICRSPMAQALLRQALPGVSVISAGIGALSGYPADPSAVEVMAQHGIDISEHRAQQLTGSLVNRADLILVMGGAQKREIQARHPSKTGSVFRLGEMEQFDIDDPYRKQMMAFEDALAMIQRGVDAWVPRIRALG

Output: May be involved in assembly or function of the EPS I polymerization/export complex and/or the EpsB ATPase. Alternatively it may function in the removal of the terminal phosphate from C55-isoprenyl pyrophosphate in order to recycle the C55-isoprenyl phosphate lipid carrier used in the synthesis of polysaccharide repeat units.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.


Instruction: Predict the functional description of the protein sequence below.

Input: MPRKGPAPKRQLMTDPVYGSPLVTALINKVLRDGKRSLAQSIVYNALEGAREKTGQDPLVILKRAIDNVKPTLEVRSRRVGGATYQVPVEVRASRSTTLALRWLVQYARLRREKTMTERLMNELVDASNGLGAAVKRREDTHKMAESNKAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: What is the functional description of the protein sequence?

Input: MPRRRVVGQRKILPDPKFHNELLAKFINILMVDGKKSTAEKIVYGALDILAQKSEKDQLELFEEALDNIRPSVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWLVEAARKRGEKSMAQRLANEMLDASDSKGSAVKKREDVHRMADANKAFAHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes three successive dehydrogenation reactions that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAGSLNKVILIGNVGRDPEIRTTGEGKKIINLSLATTETWKDRITSERKERTEWHRVVIFSEGLVSVVERYVTKGSKLYIEGSLQTRKWNDNSGQEKYTTEVVLQNFNSQLILLDSKNSNNHTQDSGRSEYKHPEAKNHSFDHSDLDDEIPF

Output: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2-cyclic phosphate 5-phosphate (PRcP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.


Instruction: What is the functional description of the protein sequence?

Output: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.


Instruction: Predict the general functional description of the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: What is the functional description of the protein sequence?

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: What is the functional description of the protein sequence?

Input: MLSQTIKSGDWKGEKHVPVIEYEKEGDLVKVEVSVGKEIPHPNTPEHHIAWIQLWFHPEDGAFPILVGKVEFSNHTDPLTEPRAVFFFRTQKKGKLYALSYCNIHGLWENEVTLE

Output: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.


Instruction: Predict the functional description of the protein sequence below.

Input: MSTAQAVKIGIAEMEVVIAPNVIRTCGLGSCVGVVIYDAGKAVAGMAHVMLPHSSMARGGVINAAKYADTAVEALVQLVIAAGGRKGMLKAKLAGGAQMFSFSTVGGDMMRIGARNVEEVKKQLERLHIPVVAEDVGGHSGRTIEFNPQTGVLSIRTAAQEIKEI

Output: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.


Instruction: What is the functional description of the protein sequence?

Output: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPIILSYSGFLLAAPIPASAPFTGLNKIRLI

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.


Instruction: What is the functional description of the protein sequence?

Input: MKVTKAELAHVAVKAEQYPKNQLPELALAGRSNVGKSSFINKMLNRKGLARTSGQPGKTQTLNFYEINERLYFVDVPGYGYAKVSKTERAAWGKMIETYLSEREELKAVLQLVDIRHRPSEDDQLMYNWMKHYGIPVILVATKADKIPKGKWQKQLTAIAKTLDKEASDPLLFFSSATGLGKDEAWRTILNHLKVTE

Output: Necessary for normal cell division and for the maintenance of normal septation.


Instruction: Predict the functional description of the protein sequence below.

Input: MKTIGLDVGTKTIGVAISDAFGWTAQGLPTIQRSEDDPNRDFEALAQLIKENDVQKVVIGYPKNMNGTVGESATRSETFARTLEQQCNVQTVLWDERLTTAAAQRVLIDADVSRKKRKKAVDKMAAVFILQGYLDRQSHTLT

Output: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MKIRPLHDRVVVRRMEEERTTAGGIVIPDSATEKPMRGEIIAVGAGKVLENGDVRALAVKVGDVVLFGKYSGTEVKVDGKELVVMREDDIMGVIEK

Output: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.


Instruction: Predict the general functional description of the protein sequence.

Output: Transcriptional coactivator or corepressor of the p300/CBP-mediated transcription complex. May be involved in sex determination, early gonad development, left-right patterning during embryogenesis and differentiation of the adrenal cortex (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MAKESMKAREIKRAKLVAKYAEKRAALKQIVRTGDPAEAFEAAQKLQELPKNSNPIRMHNRCKLTGRPKGYIRQFGVSRIQFREMASNGLIPGVKKASW

Output: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.


Instruction: Predict the functional description of the protein sequence below.

Output: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKSIGCDIIKVGRFKNFLENKKKLERFFTHKEIENFKLKGGSVIESLAGKFAAKESLIKALSPLLQHKIHYGLKDIEVIKSLKGNAKFYLHNEIEKFAIKMNLKIYLTISHEKEYAIAFVMVEN

Output: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


Instruction: Predict the general functional description of the protein sequence.

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.


Instruction: Predict the functional description of the protein sequence below.

Output: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the general functional description of the protein sequence.

Input: MLSSVVIAASEEQHNPLIPEPADIVGSLICFVVILFFFWKLVLPRVKKLLDERAEAIEGNIAKADEAQHKAEALLEEYTAQLAEARADAAKIREQARTDGQKIVAEAKDTATAEAARVTASAQAQIEAERQTALVSLRGEVGSLAIDIASGVVGEVLTEDKKAQAIVDRFLADLEASEKATSNEKAGTAN

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Predict the functional description of the protein sequence below.

Output: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.


Instruction: Predict the functional description of the protein sequence below.

Output: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


Instruction: Predict the functional description of the protein sequence below.

Output: Probably involved in transcriptional regulation.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKTPPVLKRRREGVTDYRKRYRLVISRETRAVIRQTRKGLIIQLVDYVPEGDHVLVTVTNKTLKKALNIDGNNIQMYYLAGYMAAKKGISLGISGAVVDTGRAIFRKGGRIAAAIKGLIDGGLEINADEDIFPDESRLNGEHLKQRLDINEIKSKIGE

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: Predict the functional description of the protein sequence below.

Input: MSDANVPLSFSDVAANKVKTLIAEEENPELKLRVYITGGGCSGFQYGFTFDEKVNDGDMTIENSGVTLVVDPMSLQYLVGGIVDYTEGLEGSRFFVNNPNATTTCGCGASFSV

Output: Required for insertion of 4Fe-4S clusters for at least IspG.


Instruction: Predict the general functional description of the protein sequence.

Input: MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTAPNKDILSEKGIHTLEHLYAGFMRNHLNGDSVEIIDISPMGCRTGFYMSLIGTPSEQQVADAWIAAMEDVLKVESQNKIPELNEYQCGTAAMHSLKEAQQIAKNILDAGVSVNKNDELALPESMLKELRID

Output: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).


Instruction: Predict the general functional description of the protein sequence.

Input: MTRVRRGYIARRRRTKIRLFASTFRGAHSRLTRTATQQKMRALVSIYRDRGRQKREFRRLWIARINAATHENGVSYSRLINDLYKRQLLLNRKIPAQIARYNLNSLYMISNEIIKEKRD

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: What is the functional description of the protein sequence?

Input: MARIAGIDLPRNKRIEIALTYIFGIGRTTAQRILAETGVSADTRTDNLAESEVAKIRDYIDKNLKVEGDLRRDVSMDIKRLMDLGCYRGLRHRKGLPVRGQRTKTNARTRKGPARTVAGKKK

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTEYFEVGKILSPHGLKGEVKVNATTDFPEERLATGSRLFIKNNKQYEELIVENTRRHKQFYLVKFEKIDDIDQAEKICSKELYVAETDQQELPEGSYYFKDILNCPVYDAETGEKLGVLENIETPGANDIWEIKPEKGKSFWIPNIESVVKKVDLANKRIEVTLLEGLRDEN

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MGVSLLWALLQDMVLAAIPALGFAMVFNVPVRALRYCALLGAIGHGSRMLMIHFGMNIELASLVASIMIGINWSRWLLAHPKVFTVAAVIPMFPGISAYTAMISVVEISHLGYSEALMSTMVTNFLKASFIVGALSIGLSLPGLWLYRKRPGV

Output: Involved in succinate export with YjjP. Both proteins are required for export.


Instruction: Predict the functional description of the protein sequence below.

Input: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKVRTRVTNTEQLVFIAALNISYELTQEKAKTRDYAASMEQRIRMLQQTIEQALLDQGRITEKTGQNFE

Output: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.


Instruction: What is the functional description of the protein sequence?

Input: MLQPTRLKYRKQQKGRNTGIATRGNKVSFGEFGLKAVGRGRLTARQIEAARRAMTRHIKRGGRIWIRVFPDKPITEKPIQVRMGGGKGNVEYYIAEIKPGKVLYEMDGVPEELAREAFELAAAKLPIPTTFVVRQVGQ

Output: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Input: MEINRDEFKEVVVNIGRVTKVVKGGRRFRFNALVVVGNKNGLVGFGLGKAKEVPDAIKKAVDDAFKNIIKVNVKGTTIAHDIEHKYNASKILLKPASEGTGVIAGGSARPVIELAGIKDILTKSLGSNNPYNVVRATIDALSRIKA

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the general functional description of the protein sequence.

Input: MLVLSRKKNESIVINNDIKIVVVEIRGDKVRLGVEAPREVPVHRREVYDAIQRNNEAFDANAPADSNDVS

Output: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.


Instruction: Predict the functional description of the protein sequence below.

Input: MQNFTVHQGVVATLDRANVDTDQIIPKQFLKRIERTGFGQFLFFDWRFLEDGETENPDFELNRINVKGASILLTRQNFGSGSSREHAVWALDDYGFRAVIAPSFADIFFNNCFKNGVLPIALSEEDVEELFQRAEKGNPYQLTVDLENQVITDGQGFERSFEVDASRRHNMLHGLDDIAQTLLHEDKITAFEEARG

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.


Instruction: What is the functional description of the protein sequence?

Input: MSNPQQLRYSKEHEWLSGAEDGVSTVGITEHAANALGDVVYVQLPEVGDTVTAGETCGELESTKSVSDLYSPVTGEVVEANQDVVDDPSLVNSAPFEGGWLFKVRVAEEPKDLLSADEYTEFSGS

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Instruction: What is the functional description of the protein sequence?

Input: MRDYKQLNGLALAYVGDAIYEIYIRDYLVSLGQTKPNVLHRMATHYVSAKAQASLMQAMLAGEMLTEEEEVMYKRGRNAKSHTFAKNADVTTYRVATGFESLMGYLHLTQQKERLEELINWCIKKVGETNEK

Output: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.


Instruction: Predict the general functional description of the protein sequence.

Input: MTMTDPLSDMFSRIRNANQVLHKKVTVPSSRLKVSIADLLKREGYILDYSVIDEHPGQLLVIELKYGPDKSRALVGLKRVSKPGLRVYAKSSNLPEVFGGLGIAILSTSSGLLTCSQARKKGVGGEVLAYAW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.;


Instruction: Can you provide the functional description of the following protein sequence?

Output: Acts as a chaperone.


Instruction: What is the functional description of the protein sequence?

Output: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.


Instruction: What is the functional description of the protein sequence?

Input: MIQMQTNLDVADNSGARRVMCIKVLGGSKRRYATIGDIIVVSIKEAIPRGKVKKGDVMKAVVVRVRKDIRRADGSVIRFDRNAAVLINNQSEPVGTRIFGPVPRELRAKNHMKIISLAPEVL

Output: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Input: MISLMEARNLRKERTGVVLSNKMEKTITVAAKFKEKHPIYGKFVSKTKKYHAHDEKNECNIGDTVRIMETRPLSKTKRWRLVEIIERAK

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKTLLLTLVVVAIVCLDLGYTLTCLICPEKDCQKVHTCRNEEKICVKRFYDKNQLGWRAQRGCAVSCPKAKPNETVQCCSTDKCNK

Output: Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).


Instruction: Predict the general functional description of the protein sequence.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.