Instruction: Predict the general functional description of the protein sequence.

Output: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.


Protein Function Description

Instruction: What is the functional description of the protein sequence?

Input: MNSSNIRRIQNEYNKINNDKNLYADSFQINMVDENIFLWKVNIKGPENSLYENYNFELEIELSNDYPYSSPKVKFITPIQHMNVNDKGDICLNILKKDGWNASLNIISIIWSIIVLLDQPNPEDPFNSELASLYRNDKLSYDKKIRDYCKTHSKLWTF

Output: Catalyzes the covalent attachment of ubiquitin to other proteins.


Instruction: What is the functional description of the protein sequence?

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the general functional description of the protein sequence.

Output: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of lactate to pyruvate.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: GTPase possibly involved in regulation of the MEK/ERK pathway.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for transport from the ER to the Golgi complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Highly specific endopeptidase that hydrolyzes lysyl bonds including the Lys-Pro bond.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the ferrous insertion into protoporphyrin IX.


Instruction: What is the functional description of the protein sequence?

Output: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Acts as a chaperone.


Instruction: What is the functional description of the protein sequence?

Output: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MADYSRYTVGVLALQGAVTEHISQIESLGAKAIAVKQVEQLNQLDALVLPGGESTAMRRLMEANGLFERLKTFDKPILGTCAGLILLADEIIGGEQVHLAKMAIKVQRNAFGRQIDSFQTPLTVSGLDKPFPAVFIRAPYITEVGENVEVLAEWQGNVVLAKQGHFFACAFHPELTNDNRIMALLLAQL

Output: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.


Instruction: Predict the general functional description of the protein sequence.

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Arylphorin is a larval storage protein (LSP) which may serve as a storage protein used primarily as a source of aromatic amino acids for protein synthesis during metamorphosis. It is a constituent of the sclerotizing system of the cuticle, and serves as a carrier for ecdysteroid hormone (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.


Instruction: What is the functional description of the protein sequence?

Output: Matrix protein p16 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane.;


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKLINAYTDGSCLGNPGPGGWAVLLRYKNNEKELVGGELDTTNNRMELMAAIMALERLSEPCQIKLHTDSQYVRQGITEWMSGWVRRGWKTAAGDPVKNRDLWERLCAATQRHMIEWCWVKAHNGDSDNERVDVLARGQAMAQRSTVASR

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


Instruction: Predict the general functional description of the protein sequence.

Output: Transcription coactivator that associates with the serum response factor (srf) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The srf-mrtfa complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Mrtfa binds G-actin via its RPEL repeats, regulating activity of the mrtfa-srf complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.


Instruction: What is the functional description of the protein sequence?

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


Instruction: Predict the general functional description of the protein sequence.

Input: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.


Instruction: What is the functional description of the protein sequence?

Input: MTHYEGDLRPTTARFVIIASRWNARITDALVTGARQSLAGNGIGEDAIDVVRVPGAWEIPMAANRVAQGGQHAAIIALGCVIRGDTRHYEHVADLCAEGLMSVQLQTGVPVLNGVLAVERVEDAEARAGGSHGNKGEECALAALELVNLMELLP

Output: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the biosynthesis of agmatine from arginine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Input: MSALGFPKTPSDKKALEEGAVFSPRFDPAGLVTVVVTDAEDGMLLMVAHMNAQALALTLETGIAHYWSRSRNALWKKGETSGNFQHVVEMRTDCDQDALWLRVKVLGHDATCHTGRRSCFYRTVGLVDGKGTLVDDGSKPLFDAEFTYRKPSS

Output: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.


Instruction: What is the functional description of the protein sequence?

Output: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Esterase that exhibits the highest activity towards Tween detergents and p-nitrophenyl esters of short acyl chain length. Also displays a low thioesterase activity towards palmitoyl-coenzyme A, but is not active towards acetyl-coenzyme A.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


Instruction: Predict the general functional description of the protein sequence.

Input: MGVFTFEDESTSTIAPARLYKALVKDADAIIPKAVEAIQSIETVEGNGGPGTIKKLTLIEGGETKYVLHKIEAVDEANLRYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIENYLSAHPEYN

Output: Class II ribonuclease (RNase) (By similarity). Binds to cytokinins (By similarity). Interacts with melatonin (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: This protein is involved in the repair of mismatches in DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine. SMM biosynthesis (by MMT1) and degradation (by HMT-1, HMT-2 and HMT-3) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level. Also able to catalyze the selenium-methylmethionine (SeMM) from AdoMet and selenium-methionine (SeMet). May play a role in phoem sulfur transport; such function is however not essential.


Instruction: Predict the functional description of the protein sequence below.

Output: Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAVQRTLLVVKPDGVERGLIGEVVSRVERKGLKIVAMKMMRLTREKAEEFYSVHRDKPFFGELVEFITSGPVVAMVVEGDEAVSVVRLMIGSTDGRKAAPGTIRGDFSLDIMKNIVHASDSPESFEREFRVLFSESEIVEW

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: Predict the functional description of the protein sequence below.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.


Instruction: Predict the general functional description of the protein sequence.

Input: MKQLFLIIGAPGSGKTTDAELIAKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSSKGIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNERVFHNRMRVFLDPLVEIQNFYKAKHLHKIINGERSIEEIVNEMQKYILSFAN

Output: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


Instruction: Predict the general functional description of the protein sequence.

Output: Slowly hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. May be involved in the synthesis of the cell wall peptidoglycan (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Ketoisovalerate reductase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity . Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: ABC multidrug transporter; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic . May be involved in the efflux of leucinostatins (Probable).


Instruction: What is the functional description of the protein sequence?

Output: Cysteine methyltransferase effector that inhibits host cell NF-kappa-B activation by preventing nuclear translocation of host protein RELA/p65 . Acts by mediating cysteine methylation of host proteins TAB2 and TAB3: methylation of a conserved cysteine residue of the RanBP2-type zinc finger (NZF) of TAB2 and TAB3 disrupts zinc-binding, thereby inactivating the ubiquitin chain-binding activity of TAB2 and TAB3, leading to NF-kappa-B inactivation. Also mediates cysteine methylation of host protein ZRANB3, inactivating its ability to bind ubiquitin chains (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pleuromutilin, a tricyclic diterpene showing antibacterial properties . The geranylgeranyl diphosphate (GGPP) synthase ple4 catalyzes the first step in pleuromutilin biosynthesis . GGPP is then substrate of the premutilin synthase (PS) ple3 to yield premutilin . Premutilin synthase is a bifunctional enzyme composed of the fusion of a class II diterpene cyclase (DTC) and a class I diterpene synthase (DTS), with the corresponding domains and active sites containing characteristic aspartate-rich motifs (By similarity). GGPP is first converted to mutildienyl-diphosphate (MPP) at the class II DTC site (By similarity). MPP is subsequently further cyclized at the class I DTS site, followed by a 1,5-hydride shift and addition of water prior to terminating deprotonation, to yield premutilin (By similarity). The cytochrome P450 monooxygenases ple5 and ple6 hydroxylate premutilin at C-11 and C-3, respectively, producing 11-hydroxypremutilin and 3-hydroxypremutilin . The combination of the actions of both ple5 and ple6 leads to the production of 3,11-dihydroxypremutilin . The short chain dehydrogenase ple7 further converts 3,11-dihydroxypremutilin into mutilin . The acetyltransferase ple2 then acetylates mutilin to produce 14-O-acetylmutilin . Finally, the cytochrome P450 monooxygenase ple1 catalyzes hydroxylation on the alpha position of the acetyl side chain of 14-O-acetylmutilin to yield pleuromutilin .


Instruction: Predict the functional description of the protein sequence below.

Input: MLDIKKIKEILPHRYPFLLVDRVISVEEGKKVTAIKNVTANEEFFNGHFPEYPVMPGVLIVEALAQTSGIAMMQSEANKGKIGLFAGIDGCRFKRQVIPGDQLLLEAEITRMRGAIAKAKVKATVEGDLVCEAEIMFALSDLPK

Output: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MEIGQYQPNLEGDGLRIGIVQSRFNEPVCNGLADACVEELERLGVTGEDVLLVSVPGALEIPLALQKLAESGQFDALIALGAVIRGETYHFELVSNESGAGITRIGLDFNLPIANAVLTTENDEQAVARMTEKGRDAARVAVEMANLTMALDQLGDDEDEEEDEDDEEERA

Output: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


Instruction: What is the functional description of the protein sequence?

Input: MMIDIPDDRLVAGVDEVGRGPLVGDVVTAAVILDPANPIIGLNDSKKLSEKKRLALFDEIKEKALAWSVGRASPAEIDELNILHATMLAMQRAVAGLSIAPELVFIDGNRCPSLSMEARAVVKGDSLVAAISAASILAKVTRDAEMTELDSRHPEYGFARHKGYPTAEHLAILAERGPLPEYRKSFKPVRRALGIE

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLRTMLKSKIHRATVTQADLHYVGSVTIDADLMDAADLLEGEQVTIVDIDNGARLVTYAITGERGSGVIGINGAAAHLVHPGDLVILIAYGTMQDAEARAYQPRIVFVDADNKQIDVGHDPAFVPAFDIPGAEELLNPRIGAR

Output: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).


Instruction: Predict the general functional description of the protein sequence.

Output: Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: Predict the functional description of the protein sequence below.

Input: MAHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEAGFRAREAAVIDELTGRDGVVVATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHDTNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGRARSVARRIVEALQGQPS

Output: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.


Instruction: Predict the functional description of the protein sequence below.

Output: PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Involved in both the histidine and tryptophan biosynthetic pathways.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.;


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.


Instruction: Predict the general functional description of the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).


Instruction: Predict the general functional description of the protein sequence.

Input: MIEFVYPHTHLVAGVDEVGRGPLVGAVVTAAVILDPARPIVGLNDSKKLSEKRRLALFDEIKEKALAWSLGRAEPEEIDELNILHATMLAMQRAVAGLKIVPEYVLIDGNRCPALPMRSLAVVKGDSRVAEISAASIIAKVTRDAEMAALDLSYPQYGFAQHKGYPTAFHLEKLSEHGPTEHHRRSFGPVKRALGLVC

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the synthesis of activated sulfate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).


Instruction: Predict the functional description of the protein sequence below.

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: Predict the general functional description of the protein sequence.

Input: MPIRARIIGIDPGLRFTGFGIIEADGNRLRHVADGVIATDGAAAVAERLHTLDAALARLLATYAPDHAAVEETYVNRNATATLKLGYARGVALLAPARAGIAVAEYGAKTVKRAVVGTGAAEKDQVALMVRRLLPGAAITRADAADALAVAICHAHHLATASRVPAA

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.


Instruction: Predict the functional description of the protein sequence below.

Output: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.


Instruction: Predict the general functional description of the protein sequence.

Input: MIPRTRTLLQSKIPITRYFARCWAPRVRYNVCRTLPAAALHTNIIAHNEVKKDDKKVHLGSFKVDKPKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLKIFHDHHVTVEQLMKANGEQVSQDVGDLEFEDIPDSLKDVLGKYAKNNSENASQLPHPSQK

Output: Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: What is the functional description of the protein sequence?

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: What is the functional description of the protein sequence?

Output: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.


Instruction: Predict the functional description of the protein sequence below.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MHQVISATTNPAKIQAILQAFEEIFGEGSCHITPVAVESGVPEQPFGSEETRAGARNRVDNAQRLHPQADFWVAIEAGIDDDATFSWVVIDNGVQRGEARSATLPLPAVILDRVRQGEALGPVMSHYTGIDEIGRKEGAIGVFTAGKLTRSSVYYQAVILALSPFHNAVYR

Output: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


Instruction: What is the functional description of the protein sequence?

Input: MSDSVELYTDGACKGNPGPGGWGVLLIYKGVEKELWGGERETTNNRMELMAAIQGLMALKRECEVVLTTDSQYVMKGINEWMVNWKKRGWKTAAKEPVKNADLWQQLDEQVNRHKVTWKWVRGHIGHPGNERADQLANRGVDEVRAKR

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. Not required for induction of the aerobic NO-detoxifying enzyme NO dioxygenase. Binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.


Instruction: Predict the functional description of the protein sequence below.

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: Predict the general functional description of the protein sequence.

Input: PGAGSQEERMQGQMEGQDFSHEERFLSMVRE

Output: Has antifungal activity against C.gloeosporioides but not against B.cinerea and Fusarium sp. or against various yeasts. Has no antibacterial activity.


Instruction: What is the functional description of the protein sequence?

Input: GGEEQFDDYGHMRF

Output: Myotropic peptide.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.


Instruction: Predict the functional description of the protein sequence below.

Output: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MHQVISATTNPAKIQAILQAFEEIFGEGSCHITPVAVESGVPEQPFGSEETRAGARNRVDNARRLHPQADFWVAIEAGIDDDATFSWVVIDNGVQRGEARSATLPLPAVILDRVHQGKALGPVMSQYTGIDEIGRKEGAIGVFTAGKLTRSSVYYQAVILALSPFHNAVYR

Output: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.


Instruction: Predict the general functional description of the protein sequence.

Input: MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGGIILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVYT

Output: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.


Instruction: Predict the general functional description of the protein sequence.

Input: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELGAREIAEKALDIAGDICIYTNHFHTIEELTAKA

Output: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the biosynthesis of agmatine from arginine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Predict the functional description of the protein sequence below.

Output: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.


Instruction: Predict the general functional description of the protein sequence.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the general functional description of the protein sequence.

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: Predict the functional description of the protein sequence below.

Input: MRIIGVDPGYGILGYGILEKNKNKISHVTHGVITTEKDVPMYKRLGYIYDRFVELLEEYSPDACAIESLFFYKNVKTAIHVGEARGVILLASSQRNIPLYEFTPYQVKNNVTGYGRADKKQVQKMVKMLLNLNDIPKPDDAADALAVAWCLAVEIKA

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA

Output: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the ferrous insertion into protoporphyrin IX.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.


Instruction: Predict the functional description of the protein sequence below.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: Predict the general functional description of the protein sequence.

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Zeins are major seed storage proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.


Instruction: Predict the general functional description of the protein sequence.

Output: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


Instruction: Predict the functional description of the protein sequence below.

Output: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.


Instruction: What is the functional description of the protein sequence?

Output: Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways . Catalyzes the conversion of mevalonate diphosphate to isopentenyl diphosphate (IPP) .


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.


Instruction: What is the functional description of the protein sequence?

Output: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity).;


Instruction: Predict the general functional description of the protein sequence.

Output: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Represents a citryl-ACP lyase.


Instruction: What is the functional description of the protein sequence?

Output: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.


Instruction: What is the functional description of the protein sequence?

Output: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible phosphorylation of UMP to UDP.


Instruction: Predict the functional description of the protein sequence below.

Output: The v-erbB oncogene transforms avian fibroblasts and erythroblasts in culture and induces sarcomas and erythroleukemias in chickens. It is a truncated and mutated version of the receptor for epidermal growth factor.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: RTCYKTPSVKPETCPHGENICYTETWCDAWCSQRGKRVELGCAATCPKVKAGVGIKCCSTDNCNPFPVWNPRG

Output: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.


Instruction: Predict the functional description of the protein sequence below.

Output: The A protein is a specific endonuclease that cleaves the viral strand of supertwisted, closed circular DNA at a unique site in the A gene. The A protein also causes relaxation of supertwisted DNA and forms a complex with viral DNA that has a discontinuity in gene A of the viral strand.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTATFDKVADIIAETSEIDRATITPESHTIDDLGIDSLDFLDIVFAIDKEFGIKIPLEKWTQEVNEGKVSTEEYFVLKNLCAKIDELKAAKA

Output: Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A. Is acylated predominantly with 27-hydroxyoctacosanoic acid (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK

Output: With S4 and S5 plays an important role in translational accuracy.;


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the functional description of the protein sequence below.

Input: FLSLIPTAINAVSAIAKHF

Output: Antimicrobial peptide with low activity against Leishmania species (L.amazonensis and L.infantum) . Shows low cytotoxicity against mammalian cells in models of peritoneal macrophages .


Instruction: Can you provide the functional description of the following protein sequence?

Input: ADGIFAIDQFTKVLLNYTGHITWNPPAIFKSYCEIIVTYFPFDEQNCSMKLGTRTYDGTVVAIYPEGPRPDLSNYMQSGEWALKDYRGFWHSVNYSCCLDTPYLDITYHFILLRLPLYFIVNVIIPC

Output: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Does not bind alpha-bungarotoxin.


Instruction: Predict the general functional description of the protein sequence.

Input: TPEHQRYIELFLVVDSGMFMKYNGNSDKI

Output: Snake venom zinc metalloproteinase that impairs hemostasis in the envenomed animal.


Instruction: What is the functional description of the protein sequence?

Input: MAGRSGDSDEDLLKTVRLIKFLYQSNPPPSNEGTRQARRNRRRRWRERQRQIRTISERILSTYLGRPAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGNPEILVESPTVLESGTKE

Output: Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev itself is translated from a fully spliced mRNA that readily exits the nucleus. Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs. Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface. Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export. Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import. The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.


Instruction: What is the functional description of the protein sequence?

Output: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes (nif operon), glnA and dctA for dicarboxylate transport. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator proteins NifA, NtrC, or DctD for the expression of the regulated proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAQQADQQTVTDSTPELPTTIKELADLLDIPLVDCLVPCNFCGKFLDFLEVCDFDKKQLTLIWKGHFVTACCRSCCAATAIYEFNEFYQQTVLGRDIELATGKSIFDLKIRCQTCLSFLDTIEKLDSCGRGLPFHKVRDRWKGICRQCKHLYLNNDR

Output: Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.


Instruction: What is the functional description of the protein sequence?

Input: MQLVLAAKYIGAAIATIGLLGAGIGIAIVFAALINGTSRNPSLRNTLFPFAILGFALSEATGLFCLMISFLLLYGV

Output: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.


Instruction: Predict the general functional description of the protein sequence.

Input: MKKQNLVSFSDNLEAMRKFSETYAKRTGTFFCADNSVTAVVIEGLARHKDKYGAPLCPCRHYEDKKAEISATYWNCPCVPMRERKECHCMLFLTPDNEFTSDLQEIDKTTLLEKIASS

Output: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.


Instruction: Predict the general functional description of the protein sequence.

Input: MTDDNIRQIAFYGKGGIGKSTTSQNTLAAMAEMGQRILIVGCDPKADSTRLMLHSKAQTTVLHLAAERGAVEDI

Output: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.


Instruction: Predict the functional description of the protein sequence below.

Output: Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.


Instruction: Predict the general functional description of the protein sequence.

Input: MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC

Output: Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MVHFTAEEKAAITSLWGKMNVEEAGGEALGRLLVVYPWTQRFFDNFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKTTFAKLSELHCDKLHVDPENFRLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALGHKYH

Output: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.


Instruction: Predict the general functional description of the protein sequence.

Output: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.


Instruction: Predict the functional description of the protein sequence below.

Output: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.


Instruction: Predict the general functional description of the protein sequence.

Output: Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.


Instruction: Predict the functional description of the protein sequence below.

Output: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MIGIVLVLASLLSVGGQLCQKQATRPLTTGGRRRHLMLWLGLALICMGAAMVLWLLVLQTLPVGIAYPMLSLNFVWVTLAAWKIWHEQVLPRHWLGVALIISGIIILGSAA

Output: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.


Instruction: Predict the functional description of the protein sequence below.

Input: RVCYAIPLPICY

Output: Antibacterial activity against B.subtilis, E.coli, S.aureus, M.luteus and P.putida. Antifungal activity against S.cerevisiae.


Instruction: Can you provide the functional description of the following protein sequence?

Input: SDPKIGDGCFGLPLDHIGSVSGLGCNRPVQNRPKK

Output: Exhibits vasoactive  and hypotensive activity (By similarity). Is only weakly active on natriuretic peptide receptor-C (NPR3).


Instruction: Predict the general functional description of the protein sequence.

Output: This protein functions as a defense against chitin-containing fungal pathogens.


Instruction: Can you provide the functional description of the following protein sequence?

Input: ASAAGAVRAGDDETLLNPVLNSLDNLVSGL

Output: Lacks antimicrobial activity. Does not inhibit the formation of NO by neuronal nitric oxide.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Terpene cyclase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones . The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B . Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B . The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation . Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: An ATPase (shown for residues 80-506) . Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the functional description of the protein sequence below.

Output: Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the ferrous insertion into protoporphyrin IX.


Instruction: Predict the functional description of the protein sequence below.

Input: MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVAESEITIIRAPGAFEIPLVTQKVAQQGGFDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSLQFGIPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK

Output: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


Instruction: Predict the functional description of the protein sequence below.

Output: May play a role in the merozoite attachment to the erythrocyte.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.


Instruction: What is the functional description of the protein sequence?

Output: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.


Instruction: Predict the functional description of the protein sequence below.

Output: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible phosphorylation of UMP to UDP.


Instruction: What is the functional description of the protein sequence?

Output: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation.


Instruction: What is the functional description of the protein sequence?

Output: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.


Instruction: What is the functional description of the protein sequence?

Input: MRVGLYPGTFDPITLGHLDIIRRASALLDKLVIGVAINRDKGPLFCLEERVAMVEAESIKIAAMTGLEIVTHPFENLLIDCARDVGATVIVRGLRAVADFEYEYQMVGMNRQLDDTIETVFLMAEAEHQAIASKLVKEIARLGGDIEKFVTPEVNAALLNKIGRAG

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.