Instruction: Can you provide the functional description of the following protein sequence?

Output: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Protein Function Description

Instruction: Can you provide the functional description of the following protein sequence?

Output: Trans-enoyl reductase; part of the gene cluster A that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial . Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities . Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins. BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives . The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable). The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable). The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable). The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).


Instruction: Predict the functional description of the protein sequence below.

Output: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.


Instruction: Predict the general functional description of the protein sequence.

Output: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


Instruction: Can you provide the functional description of the following protein sequence?

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the biosynthesis of agmatine from arginine.


Instruction: What is the functional description of the protein sequence?

Output: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSAIWIAIAVLSALSLVFGGLLGYASRRFAVEEDPIVEQIDAILPQSQCGQCGYPGCRPYADAVGNNGEMINKCAPGGEQTMLKLAALLNVEPQPLGAEEAREPERKVAWIDEANCIGCTKCIQACPVDAIVGATRAMHTVLSDICTGCDLCVAPCPTDCIEMRPVATTTANWKWDLHTIPVRVITVESHA

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


Instruction: Predict the general functional description of the protein sequence.

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.


Instruction: Predict the general functional description of the protein sequence.

Input: MSTQSRILVLNGPNLNLLGLREPAHYGSQNLEQIVNALTTQADALGVEIEHLQSNREYELIEAIHNAYQRIDFIIINPAAFTHTSVALRDALLGVDIPFIEVHLSNVHAREPFRHHSYLSDKAVGVICGLGADGYEFALNAAVKRLRSN

Output: Catalyzes a trans-dehydration via an enolate intermediate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAGRLDEDLKDVTLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSLKLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEQMADYRMMNHDLYPETIDNR

Output: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.


Instruction: What is the functional description of the protein sequence?

Output: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.


Instruction: Predict the general functional description of the protein sequence.

Input: MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.


Instruction: Predict the general functional description of the protein sequence.

Output: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.


Instruction: Predict the functional description of the protein sequence below.

Output: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAEKFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQDGRDLLEKAGYPVLSLARLDRFENGQVVFKEADL

Output: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: Predict the general functional description of the protein sequence.

Output: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.


Instruction: Predict the functional description of the protein sequence below.

Output: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.


Instruction: What is the functional description of the protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.


Instruction: Predict the general functional description of the protein sequence.

Output: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).


Instruction: What is the functional description of the protein sequence?

Input: MSCISRSRALFQIRSLASSSHLPLPKLRPSPAIYKSANKTAFNASPSTSQSATTTRGFRSTAAKMTVHNLTNAQDFKDALKSHKFVLVDFFATWCGPCRAIAPKIAEWSDAFPNIHYVKVDVDEVPDVAQEYNVRAMPTFLLFKDGEKVDEVVGANPPKLQALISANHPSS

Output: Thioredoxin involved in responses to oxidative and cell wall stresses . Plays an important role in appressorium formation on hyphal tips . TRX2 may affect invasive growth via the MST11-MST7-PMK1 pathway since it is required for the proper folding or dimerization of MAPKK MST7 .


Instruction: What is the functional description of the protein sequence?

Output: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.


Instruction: Predict the functional description of the protein sequence below.

Input: MIDNLIKKEFLAHKEALEKSLEGLQEALKQSVHLLIETLENQGKILICGNGGSASDAQHFAAELTGRYKLERKGLSAISLNTDISALTAIANDYGYEEVFARQVEALGVKNDVLIGISTSGNSKNVLKAYEKAKDLEMKTLSLAGRDGGKMKPLSDMALIVPSDDTPRIQEMHILMIHILCDCIERHFAHKN

Output: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Input: MQNHDLESIKQAALIEYEVREQGSSIVLDSNISKEPLEFIIGTNQIIAGLEKAVLKAQIGEWEEVVIAPEEAYGVYESSYLQEVPRDQFEGIELEKGMSVFGQTEDNQTIQAIIKDFSATHVMVDYNHPLAGKTLAFRFKVLGFREVSEEEILASHHGGGTGCCGGHGGHGGKKGGGCGCSCSHG

Output: Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity).;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in bacteriochlorophyll pigment biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoroporphyrin IX.


Instruction: Predict the functional description of the protein sequence below.

Input: MGKRVVYPGTFDPPHYGHLDIVKRSARIFDEVVVAVAKKPRKFLLFDAEERVKMFEKMVEDIPNVEVKMFDCLLVDFMKREGINVIVRGVRLFTDFEYELQIALTNYKLAGVETVFMMPSQEYIHISSTIVRDVASYCGDLDNMVHPYVKQKLREKFNCGS

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAARLCCQLDPARDVLCLRPVGAESRGRPFSGPFGTLSSPSPSAVSTDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHQFLPKVLYKRTLGLSVMSTTDLEAYFKDCLFKDWEELGEETRLMIFVLGGCRHKLVCAPAPCNFFTSA

Output: Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.


Instruction: Can you provide the functional description of the following protein sequence?

Output: This insecticidal carbohydrate-binding lectin is toxic for the cowpea weevil.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: VLSAADKANVKGVFSKIGGHADDYGAETLERMFIAYPQTKTYFPHFDLHHGSAQIKAHGKKVAAALVEAVNHIDDITGALSKLSDLHAQKLRVDPVNFKFLGHCFLVVVAIHHPAALTPEVHASLDKFMCAVGAVLTAKYR

Output: Involved in oxygen transport from the lung to the various peripheral tissues.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MANKQVEISMAEWDVMNIIWGKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFLNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILNDISKK

Output: Transcriptional repressor that constitutively blocks expression of beta-lactamase. Binds DNA as a dimer (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MNKTQLIDVIADKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTGRNPQTGKEIKIAAANVPAFVSGKALKDAVK

Output: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MDPQNALYYQPRVPTAAPTSGGVPWSRVGEVAILSFVALICFYLLYLWVLRDLILVLKARQGRSTEELIFGGQAVDRSNPIPNIPAPPSQGNPGPFVPGTG

Output: Involved in the viral transport within, and between cells.


Instruction: Predict the general functional description of the protein sequence.

Output: Transcriptional regulator involved in the positive regulation of the expression of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities.


Instruction: Predict the general functional description of the protein sequence.

Output: Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.


Instruction: Predict the functional description of the protein sequence below.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.


Instruction: Predict the general functional description of the protein sequence.

Output: Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.


Instruction: What is the functional description of the protein sequence?

Input: MNKLILIIDNYDSFTHNLYQMAGEIMMEMDSADIMVVRNDEVDIDYVRGLDPERIIISPGPGNPIKREDFGICSEVIGEFTDRPILGVCLGHQGIFHYFGGVVGYGEPVHGKISEVFHDGSELFRGVPNPFRATRYHSLRCECSGVPEDILVSASAPDGTIMAIRHRQYPVYGLQFHPESAGTPHGRDILENFLRM

Output: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSFTDKQEALVNSSYEAFKQNLSGYSVFFYTVILEKAPAAKGLFSFLKDSAGVQDSPQLQAHAEKVFGLVRDSASQLRATGGVVLGDAALGAIHIQKGVVDPHFVVVKEALLKTIKEAAGDKWSEELSTAWEVAYDALATEIKKAMS

Output: Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation.


Instruction: Predict the general functional description of the protein sequence.

Input: MSIILIGFMGAGKSTVAKLLAEEFTDLDKLIEEEIEMPIATFFELFGEADFRKIENEVFELAVQKDIIIATGGGIIENPKNLNVLDRASRVVFLTADFDTLWKRISMDWQNVRPLAQDKEAAQLLFEKRMKDYSLVADLTIDVTDKSPEQIAEQIREKWEIE

Output: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Chloroplast omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes. It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol.


Instruction: What is the functional description of the protein sequence?

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.;


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).


Instruction: What is the functional description of the protein sequence?

Output: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


Instruction: Predict the functional description of the protein sequence below.

Output: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.


Instruction: Predict the functional description of the protein sequence below.

Input: DGYIRRRDGCKVSCLFGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG

Output: Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.


Instruction: What is the functional description of the protein sequence?

Input: FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ

Output: Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores. Has antimicrobial activity against Gram-negative bacterium E.coli, Gram-positive bacteria B.subtilis and S.aureus, and hemolytic activity against sheep, pig and guinea pig erythrocytes. Has insecticidal activity against S.frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides.


Instruction: Predict the general functional description of the protein sequence.

Input: GSSGMIPFPRV

Output: Mediates visceral muscle contractile activity (myotropic activity).


Instruction: Predict the functional description of the protein sequence below.

Input: GTIPCGESCVFIPCLTSALGCSCKSKVCYKN

Output: Probably participates in a plant defense mechanism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: VATSEQFNKTFIELVIVVD

Output: Catalytic subunit of coagulation factor X-activating enzyme, a zinc-protease enzyme that acts in hemostasis. Activates coagulation factor X (F10) by cleaving the Arg-Ile bond at position 234 and is also able to activate coagulation factor IX (F9) and protein C (PROC) by specific cleavage of Arg-Ile and Arg-Val bonds (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.


Instruction: What is the functional description of the protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Predict the functional description of the protein sequence below.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.


Instruction: Predict the functional description of the protein sequence below.

Output: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.


Instruction: Predict the general functional description of the protein sequence.

Output: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase aurka-a/Aurora A during mitotic progression by promoting aurka-a removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose.


Instruction: What is the functional description of the protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.


Instruction: What is the functional description of the protein sequence?

Output: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.


Instruction: What is the functional description of the protein sequence?

Input: MFNFINSLKNYSQESFRAARYIGQGFIVTLNHINRSAITVQYPYEKLITSERFRGRIHFEFDKCIVCEVCVRVCPINLPVVDWNFQQDIRKKKLKNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSVYDRHELNYDQIALGRLPFNSFQDALVTKAS

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.


Instruction: What is the functional description of the protein sequence?

Input: MADSHGNAKGATAHTEAGGGHKAPFPPFQKDTFASQLVSLTIAFVALYLISSRLALPRVRKTIDDRQNKIEGDIAQAQTLKNESDAALKAYEVELAAARTRAQAIGNETREKLNAEADTERKALEKRLSAKLADAEKTIASTRTAAMSNVRGIASDAATAIVQQLTGAMPDRKLVDSAVEASMKG

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).;


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.


Instruction: Predict the functional description of the protein sequence below.

Input: MNGFSTEEDSRDGPPAQAAPFFGQTCCLIDGGERCPRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNYIQSVRNKRKRKTSDDGGDSPEHETDVPEVDLFQLQVNTLRRYKRYYKLQTRPGLNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKSESSKQLEA

Output: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


Instruction: Predict the functional description of the protein sequence below.

Output: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.


Instruction: Predict the general functional description of the protein sequence.

Output: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MDLSEPIHDFLLVFLGSGLILGGLGVVLLPNPIYSAFSLGLVLVCTSLFYILSNSYFVAAAQLLIYVGAINVLIIFAVMFMNGSEYYKDFHLWTVGNGITSMVCISLFISLITTISDTSWYGIIWTTRSNQIIEQDFLSNSQQIGIHLSTDFFLPFELISIILLVALIGAIAVARQ

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.


Instruction: Predict the general functional description of the protein sequence.

Output: Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).


Instruction: What is the functional description of the protein sequence?

Input: MSQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPIIDPEALYKK

Output: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NAD- or NADP-dependent conversion of 3-hydroxybenzoate to gentisate. The affinity of the enzyme toward NAD is twice as high as for NADP.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible phosphorylation of UMP to UDP.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARNLLFATVEIESEERWNAVASTDVCQRWWKYMTDVMPANPDNSPVSSELQEVFYLP

Output: Involved in the anomeric conversion of L-rhamnose.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MASSVLSSAAVATVSRTPAQASMVAPFTGLKSTVGFPATKKNDDITSLASNGGRVQCMKVWPTQNMKRYETLSYLPPLTTDQLARQVDYLLNNKWVPCLEFETDHGFVYREHHNSPGYYDGRYWTMWKLPMFGCTDPAQVLNELEECKKEYPNAFIRIIGFDSNRQVQCVSFIAYKPAGY

Output: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae. Toxic to Plutella xylostella.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.


Instruction: What is the functional description of the protein sequence?

Input: MLRTMLNGKIHRATVTHADLHYVGSITIDADLMDAANLVDGEQVHVVNITNGHRLVTYVLTGERGSGVIGINGAAARLVAPGDLVIIISYVQLTEAERATHRPHVVHVDANNRIVALGDDLAEPVPGSDQKSGALLP

Output: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.


Instruction: What is the functional description of the protein sequence?

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.


Instruction: What is the functional description of the protein sequence?

Output: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.


Instruction: Predict the general functional description of the protein sequence.

Output: Maleylacetoacetate isomerase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin . The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA) . The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD . The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate . When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization . On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate . 4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).


Instruction: What is the functional description of the protein sequence?

Input: MATQPPQDQTSTTPSLPPHLDPTTYPRILTSATHNIHLELTYSTLNPTVALEHTSSPAAGANVLFLGTTRDTFEGRAVSQLSYTSYPPLALKSLMSIATRAVEKFDLKGVYIAHRLGVVPISEASIVVAVSAGHRGMAWKAAEEVLEEVKEKVEIWKREEFVDGGMEWRENRERDAEGRILSSTEGGK

Output: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.


Instruction: What is the functional description of the protein sequence?

Output: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).


Instruction: What is the functional description of the protein sequence?

Output: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSQTITLIKDKILSDNYFTLRNITYDLTRRNGEVIRHKREVYDRGNGATILLYNSTKKTVLLVRQFRVATWVNGNQDGMLIETCAGLLDNDEPEVCIRKEAIEETGYDVGEVRKIFELYMSPGGVTELIHFFIAEYHDSERASIGGGVEDEEIEVLELPFSRALEMVRSGEIRDGKTVLLLNYLQTSHLMD

Output: Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MDVLELYRRTGALLEGHFLLRSGMHSPFFLQSAALLQHPLYAEAVGEALGKLFKDEKVDFVIAPAIGGVVLSFVVAKALGARALFAEKDGRGGMLIRKGLTVNPGDRFLAVEDVVTTGESVRKAIRAAEARGGVLVGVGAIVDRSGGRAAFGVPFRALLALEVPHYPEEACPLCREGVPLEEV

Output: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


Instruction: Predict the functional description of the protein sequence below.

Input: MAGRQEKELQNVTLLGSEQTEYKYSYDPRVLETFDNQHPYRDYMVKFNCPEFTTLCPKTGQPDFATLYISYIPEQKMVESKSLKLYLFSFRNHGDFHEDSVNTIMNDLIELMDPRYIEVWGKFTPRGGISIDPYCNYGKKGTKYEEIANYRLMNHDLYPETITNR

Output: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


Instruction: Predict the general functional description of the protein sequence.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Input: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT

Output: Catalyzes the deamination of dCTP to dUTP.


Instruction: What is the functional description of the protein sequence?

Input: MNRTKLVLGAVILASTMLAGCSSNAKIDQLSSDVQTLNAKVDQLSNDVNAVRADVQAAKDDAARANQRLDNQAQAYKK

Output: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.


Instruction: What is the functional description of the protein sequence?

Input: MSEIITVKRLFSDAKIPVRHSEGAAAYDLYAYEDTVVAPNERKVIATGVRITVPLSCQGTIYSRSGLALKYCIEIFGVNIGPGETKDIVVDIYNHGKMPFNVAKGDRIAQIVFIKLFGGDLHEVSELSDTKRGSCGWGSTGIS

Output: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Instruction: What is the functional description of the protein sequence?

Output: Component of the type IV secretion system VirB/VirD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function.


Instruction: Predict the general functional description of the protein sequence.

Output: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).


Instruction: What is the functional description of the protein sequence?

Output: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.


Instruction: Predict the functional description of the protein sequence below.

Output: Exhibits GTPase activity. Binds RNA but is probably not involved in ribosome assembly in mycobacteria.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKKPFRIGFGFDVHRLSEGYPLWMGGVRLEHSKGLEGHSDADVLIHAICDALLGAAALRDIGYHFPPSDPQYKGIDSKILLARVMELVRSQGYELGNIDATIAAEQPKLNPHIPDMQRVLAEVIQVEVSDISLKATTTEKLGFTGREEGISAYAVALLIAAV

Output: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).


Instruction: What is the functional description of the protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in cholesterol degradation. Catalyzes the conversion of propanal to propanoyl-CoA, using NAD(+) and coenzyme A.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Output: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. May also be required for sister chromatid cohesion.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the interconversion of ornithine to glutamate semialdehyde.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the biosynthesis of capreomycidine, an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotic such as viomycin and capreomycin. Catalyzes the dehydration of the C3 hydroxyl of (3S)-hydroxy-(2S)-arginine and the intramolecular cyclization to yield (2S,3R)-capreomycidine.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.


Instruction: What is the functional description of the protein sequence?

Output: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVELAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Converts the aldose L-fucose into the corresponding ketose L-fuculose.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MFPMVTEFMNYGQQTVRAARYIGQGFTITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPETKT

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).


Instruction: Predict the general functional description of the protein sequence.

Input: MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEANSTNNRMELMAAIMALETLTEPCQILLHTDSQYVRQGITEWMPGWVRRGWKTSGGDPVKNRELWERLHAATQRHSIEWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Predict the functional description of the protein sequence below.

Input: MVRYRMRSPSESPHQGPGQDHESEEQGQGQELNPERVEDYGRTHRGHHRHRRCSRKRLHRIHKRRRSCRRRRRHSCCHRRRHRRGCRRSRRRRRCRCRKCRRQCH

Output: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.


Instruction: What is the functional description of the protein sequence?

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.


Instruction: What is the functional description of the protein sequence?

Output: Involved in DNA double-strand break repair. Is not involved in recombination during natural competence or in plasmid establishment.;


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


Instruction: Predict the general functional description of the protein sequence.

Output: May play a role in the merozoite attachment to the erythrocyte.