Instruction: What is the functional description of the protein sequence?

Input: MADAVLFEFLHTEMVAELWAPDPDPGSGGKRRSLSVLEGLGFRVGQALGERLPLETPAFREELDALKFLCRDLWAAMFQKHMDGLRTNHQGTYVLQDNSFPLLVTMGSGPQYLEEAPKFLAFTCGLLCGALHTLGFQSLVTASVASLPACKFQVVIQKS

Output: May play a role in vesicular transport during the biogenesis of melanosomes.


Protein Function Description

Instruction: Predict the general functional description of the protein sequence.

Output: May be involved in transcriptional regulation.


Instruction: Predict the functional description of the protein sequence below.

Output: Possesses E3 ubiquitin-protein ligase in vitro.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Permease involved in the transport of the cationic amino acids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May be involved in plant development processes.


Instruction: What is the functional description of the protein sequence?

Output: Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) . The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (By similarity). DprE2 then catalyzes the second step of epimerization, the NAD(+)-dependent reduction of DPX that leads to the formation of DPA .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


Instruction: Predict the general functional description of the protein sequence.

Output: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.


Instruction: What is the functional description of the protein sequence?

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.


Instruction: What is the functional description of the protein sequence?

Input: MSGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAVLVNPNKKGMFTLDERMEMIAESCAHLPNLRVESGQGLVVDFVRARGYSAIVKGLRSSTDFEYELQMAQMNKHVAGVDTFFIASAPSYSFVSSSLAKEVATLGGDVSALLPDAVNVRLQAKLRG

Output: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.


Instruction: What is the functional description of the protein sequence?

Output: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.;


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFFEDLVNFVTSGPVVAMILEGDSAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASDSKESYEREYKVFFSDDEIVGDY

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.


Instruction: Predict the functional description of the protein sequence below.

Output: Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of lactate to pyruvate.


Instruction: What is the functional description of the protein sequence?

Output: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.


Instruction: Predict the general functional description of the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


Instruction: Predict the general functional description of the protein sequence.

Output: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Transcription factor; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin . Acts as a transcriptional activator for the genes of the tyrosine degradation cluster .


Instruction: Predict the general functional description of the protein sequence.

Output: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Input: MILEHVLVLSAYLFLIGLYGLITSRNMVRALMCLELILNAVNMNFVTFSDFFDNSQLKGDIFCIFVIAIAAAEAAIGLAIVSSIYRNRKSTRINQSTLLNK

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Predict the functional description of the protein sequence below.

Output: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.


Instruction: What is the functional description of the protein sequence?

Input: MTAKSRILVLNGPNLNLLGLREPTHYGSQTLEQIVATLRDQAQKADIELEHLQSNREYELIEAIHQAFGKVDFIIINPAAFTHTSVALRDALLGVAIPFIEVHLSNVHAREPFRHHSYLSDKAQGVICGLGAQGYEFALSAAIRALQAKQ

Output: Catalyzes a trans-dehydration via an enolate intermediate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.


Instruction: Predict the functional description of the protein sequence below.

Output: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Input: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWHSIAVISYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIQYGVDQPEEICIKVFTPRKNPRIPSVFWIWKSADFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of lactate to pyruvate (Potential). Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


Instruction: Predict the general functional description of the protein sequence.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.


Instruction: What is the functional description of the protein sequence?

Output: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.


Instruction: Predict the general functional description of the protein sequence.

Input: MPIKKILLLNGPNLNLLGTREPHIYGYDTLASIESSLSTYLSSLTPSVELLTFQSNWEGALIDRIHEARTDGTDAIVINPAAFTHYSVALRDALTGVDIPFVEVHISNVHKREEFRHKSFLSDKAEAVICGLGVFGYRAAVEWCVGYLKERPKL

Output: Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.


Instruction: What is the functional description of the protein sequence?

Output: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: Predict the general functional description of the protein sequence.

Input: MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGQTPVLARVHSECLTGDALFSLRCDCGFQLEAALTHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVDEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAAKMGHLLGK

Output: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.


Instruction: Predict the functional description of the protein sequence below.

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: What is the functional description of the protein sequence?

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: What is the functional description of the protein sequence?

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: What is the functional description of the protein sequence?

Input: MERTFLMIKPDGVQRNLVGEIIQRFETKGFTLVGLKMMQVSSELAEKHYAVHKERPFFRSLVDFITSSPVVAMVWQGEGVIASARKIIGATNPLNAEPGTIRGDFGISVGRNLIHGSDGPDTAKDEVSLWFSDAELANWTPAITPWVVE

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: Predict the general functional description of the protein sequence.

Input: MYAVLTAIIAYLIGCINNAYIFTKYTRNIDIRNYGSGNAGATNVLRVLGYKAAAPVFALDVLKGVIAVLIGKYLMGNTGAMIAGIAVVCGHNWPVFLKFRGGKGIATSVGVVMTVSPLLGLIALAIGVTVIVLTKYVSLGSITGSVTFVLLNAIFWNSTQIFIFSLILASLAIFQHRSNIKRLLAGTESKLGQKTEIK

Output: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


Instruction: Predict the functional description of the protein sequence below.

Input: MIRIGHGFDVHAFGGEGPIIIGGVAIPYEKGLVAHSDGDVALHALTDALLGAMALGDIGKLFPDTDIQYKGADSRRLLRTAYQAILDKGYQVGNVDITIIAQAPKMRPYIDSMRTVIAQDLHCDIEQVNVKATTTEKLGFTGRSEGIACEAVVLLIKQNGTK

Output: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPTINQLVRKPRKSKVEKPKSPALNVGYNSHKKVQTNVSSPQKRGVATRVGTMTPRKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA

Output: With S4 and S5 plays an important role in translational accuracy.;


Instruction: Predict the functional description of the protein sequence below.

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.


Instruction: What is the functional description of the protein sequence?

Output: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the synthesis of GMP from XMP.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: Predict the general functional description of the protein sequence.

Input: MFTLKKSLLLLFFLGTINLSLCEEERDADEEERRDDPEERAVQVEKRILPILAPLIGGLLGK

Output: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus (MIC>100 uM) and the Gram-negative bacterium E.coli (MIC>100 uM). Has weak hemolytic activity against human erythrocytes.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


Instruction: Predict the functional description of the protein sequence below.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: Can you provide the functional description of the following protein sequence?

Output: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: Predict the functional description of the protein sequence below.

Input: MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARNLLFATVEIESEERWNAVASTEICQRWWKYMTDVMPANPDNSPVSSELQEVFYLP

Output: Involved in the anomeric conversion of L-rhamnose.


Instruction: Predict the functional description of the protein sequence below.

Output: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


Instruction: What is the functional description of the protein sequence?

Output: Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MFRTMMRAKLHRATVTEANLNYVGSITIDEDLMDAVNIVENEKVQIVNNNNGARLETYVIKGERGSGVVCLNGAAARLVQPGDKVIIICYGLVTEEEVHKQEPKIAVLDDNNQIIEMLGAEKAGTIL

Output: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.


Instruction: What is the functional description of the protein sequence?

Output: Transforms N(2)-succinylglutamate into succinate and glutamate.


Instruction: What is the functional description of the protein sequence?

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).


Instruction: Can you provide the functional description of the following protein sequence?

Output: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: What is the functional description of the protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: VHWTAEEKALVNVVWSKTDHQAVVANALGRLFVVYPWTKRYFAGDSAVQTHAGKVVSALTLAYNHIDDVKPHKHYEGFHVDPENFRLLANCLNVELGHTLHKEFTPELHAAWNKFSNVVVDALSKGYH

Output: Involved in oxygen transport from gills to the various peripheral tissues.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: RLALPPGAVCNGHKSDCQCFGAKYKCSCPFFWRFRKSAECHCKKGWAWTAIKKRSCHNRYQWSD

Output: Insecticidal to house crickets . It induces an excitatory slow-onset impact that leads to irreversible spastic paralysis . It also modifies human voltage-gated potassium channel Kv1.5/KCNA5 . Most likely, it binds to the voltage-sensing domain of the channel, suggesting it does not block the pore but prevents its opening at physiological membrane potentials . The recombinant peptide binds to the channel in an irreversible manner and slows down the hKv1.5 current activation kinetics . It is not toxic to mice, when intracranially injected (at 0.5 ug/g mouse) .


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPQLQGLNHLLFSVSDLEKSFCFYRDVLHAKPLVRGRKLAYFDLNGYWLALNEEPDIPRNEIAHSYTHMAFTITEESFDEWYAHLEKHGVTILHGRDRSERDKRSIYFIDPDGHKFELHTGTLQDRLAYYRDEKHHMTFFE

Output: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.


Instruction: What is the functional description of the protein sequence?

Output: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.


Instruction: Predict the functional description of the protein sequence below.

Input: MEQLKRKIREHGSVLSEQVLKVDAFLNHQVDPQLMRQIGQEFARRFRDQEIDKVITLETSGIAPALMTALELDVPLVFARKHRSLTLTDDLLTARVYSFTKQVESTVAISASHLAAGERILIVDDFLANGQAALGLAAIVRQAGARLVGIGIVIEKSFQPGRRALEEQGYRVESLARIASLAGSQVSFVE

Output: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.


Instruction: Predict the general functional description of the protein sequence.

Output: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRYVLLGPPGAGKGTQAALLSEKLGVPHISTGDLFRANIGEGTPLGLEAKSYIDAGKLVPTDVTARMVEDRLNQDDAKDGFLLDGFPRTVQQADILEKLLSDKDLKLDGVLNFEVSEDVVVERMLARGRADDTEETIRTRLGVYREETFPLIEHYGDAIISIKAEGTVEEINERTLQAMGK

Output: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


Instruction: Predict the functional description of the protein sequence below.

Input: MKNNFYQEDELLSNELSNRGFLLTKVDDVIGWARANSLWPMTFGLACCAVEMMQAAASRYDMDRFGMLFRPSPRQSDLMIVAGTLTNKMAPALRKVYDQMAEPKWVLSMGSCANGGGYYHFSYSVVRGCDRIVPVDVYVPGCPPTAEALIYGLMQLQKKIKRTTGFKYDARQTH

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: What is the functional description of the protein sequence?

Input: MSTAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE

Output: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


Instruction: Predict the functional description of the protein sequence below.

Output: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of L-arabinose to L-ribulose.


Instruction: Predict the general functional description of the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Prenyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins . Within the pathway, the prenyltransferase asqH1 catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone (By similarity). The first step of the pathway is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin. 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ. AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin. The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI. 4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B. The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene. The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain. The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin. Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).


Instruction: Predict the functional description of the protein sequence below.

Input: MRKHSDCMNFCAVDATKGICRLSKQMINLDDSACPEIKVMPKCKNCKNFVEANDEGIGKCVGLEKEDWVYSTLNAITCEGHVFNE

Output: Component of the HPA decarboxylase that decarboxylates phenylacetates with a hydroxyl group in the p-position. Active toward 4-hydroxyphenylacetate and 3,4-dihydroxyphenylacetate, forming 4-methylphenol and 4-methylcatechol, respectively. Is likely involved in the catabolism of aromatic amino acids such as tyrosine fermentation. 4-methylphenol (p-cresol) formation provides metabolic toxicity, which allows an active suppression of other microbes and may provide growth advantages for the producers in highly competitive environments (By similarity). The small subunit is essential for enzymatic activity of HPA decarboxylase, and seems also involved in the regulation of the enzyme oligomeric state and catalytic activity (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds.


Instruction: Predict the general functional description of the protein sequence.

Input: MELAKTKTGEMIDLNFARKVVEENKRVKDNRGRQEIVLFNGLTTSKLRNLLELINHVYTKVYNSDDTTLSEDVRDELEYLKVKFAYESGREPAVRTFIEKTYVDKLVDVVLKKNTKKIFLDYCKYFEALVAYAKFYRMGD

Output: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host the appropriately targeted Csm effector complex prevents growth of dsDNA phage phiNM1-gamma6.;


Instruction: Predict the general functional description of the protein sequence.

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Probably binds to the DNA sequence 5'-TGAC-3'.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.


Instruction: Predict the general functional description of the protein sequence.

Output: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (Probable).


Instruction: Predict the functional description of the protein sequence below.

Input: MPQLNPEPWLTTFLIVWISLIVILQPKIASLMLTSSPTPYKAMTIKTWPWPWT

Output: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


Instruction: Predict the functional description of the protein sequence below.

Output: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.


Instruction: Predict the general functional description of the protein sequence.

Input: MSMMNRNIGFLSRTLKTSVPKRAGLLSFRAYSNEAKVNWLEEVQAEEEHAKRSSEFWKKVTYYIGGPALILASANAYYIYCKHQEHAKHVEDTDPGYSFENLRFKKYPWGDGSKTLFWNDKVNHLKKDDE

Output: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.


Instruction: What is the functional description of the protein sequence?

Input: AGEVEKREGMMKQIGGSMGALAAISKGQKPYDAEAVKAAVTTISTNAKAFPDQFPPGSETGSAAAPAIWENFDDFKSKAAKLGADADKVLASLPADQAGVTAAMQTLGADCGACHQTYRLKK

Output: Low-spin monoheme cytochrome c.


Instruction: Can you provide the functional description of the following protein sequence?

Input: SDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATEDFEDVGHSTDARELSKTYIIGELHPDDRPK

Output: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Exonuclease that plays a role in viral genome replication, DNA recombination, and host DNA degradation.


Instruction: Predict the general functional description of the protein sequence.

Output: PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.


Instruction: Predict the functional description of the protein sequence below.

Input: MGASGSKKRSKPLQGLQERLLQARGETCGGRCNESGGGYLQSHEGSGREQNSPSCEGQRYQQGDFVNTPWRTPAAEREKELYKQQNMDDVDLDDDDQVGFPVTPRVPLRPMTFKLAVDMSHFIKEKGGLEGLFYSQRRHRILDLYLDKAFTLYPEEFGHNSGLPEKEWKARLKARGIPFS

Output: Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocyte function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells. One of the earliest and most abundantly expressed viral proteins (By similarity).;


Instruction: Predict the functional description of the protein sequence below.

Input: MEQAPEDQGPQREPYNEWTLELLEELKREAVRHFPRPWLHSLGQYIYETYGDTWAGVEAIIRILQQLLFIHFRIGCQHSRIGIIQQRRARRNGASRS

Output: During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.;


Instruction: What is the functional description of the protein sequence?

Output: Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.


Instruction: Predict the general functional description of the protein sequence.

Output: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).


Instruction: Predict the general functional description of the protein sequence.

Output: Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.


Instruction: What is the functional description of the protein sequence?

Input: VHWTAEEKSAITSIWNKVDVPAVGSEALSRLLIVYPWTQRFFTSFGNLSNAAAIQSNAQVKAHGKKVFTAFGDAVKNPEAVKETFAKLSELHCDKLHVDPINFKLLGQILITVLAAHFGKEFTPHVQASYQKLVSVVAHALAHRYH

Output: Involved in oxygen transport from the lung to the various peripheral tissues.


Instruction: Predict the functional description of the protein sequence below.

Input: MSRRGTAEKRTAKSDPIFRNRLVNMVVNRIMKDGKKSLAYQILYRAVKKIQQKTETNPLLVLRQAIRRVTPNIGVKTRRNKKGSTRKVPIEIGSKQGRALAIRWLLEASQKRPGRNMAFKLSSELVDAAKGGGGAIRKKEATHRMAEANRALAHFR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.


Instruction: Can you provide the functional description of the following protein sequence?

Output: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPSDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA

Output: Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (Kv).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Utilization of purines as secondary nitrogen sources, when primary sources are limiting.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.


Instruction: Predict the general functional description of the protein sequence.

Output: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.


Instruction: What is the functional description of the protein sequence?

Input: MSWQTYVDDHLLCEIEGNHLTHAAILGQDGSVWAKSASFPQFKPEEITGIMNDFNEPGTLAPTGLYIGGTKYMVIQGEPGSVIRGKKGPGGVTVKKTNLALVIGIYDEPMTPGQCNMIVERLGDYLIEQGL

Output: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKTLPKERRYETLSYLPPLTDQQIAKQVEFLLDQGFIPGVEFEEDPQPETHFWTMWKLPFFGGATANEVLAEVRECRSENPNCYIRVIGFDNIKQCQTVSFIVHKPNQNQGRY

Output: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.


Instruction: What is the functional description of the protein sequence?

Output: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MEITSVNHICFSVSDLNTSIQFYKDILHGDLLVSGRTTAYLTIGHTWIALNQEKNIPRNEISHSYTHIAFSIDEEDFQQWIQWLKENQVNILKGRPRDIKDKKSIYFTDPDGHKIELHTGTLKDRMEYYKCENTHMQFYDEF

Output: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.


Instruction: Predict the general functional description of the protein sequence.

Output: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSNFTAEDKAAITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGSLSSPSAIMGNPKVKAHGVKVLTSLGEAIKNLDDLKGTFGQLSELHCDKLHVDPENFRLLGNVLVTVLAILHGKEFTPEVQASWQKMVAGVASALASRYH

Output: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.


Instruction: What is the functional description of the protein sequence?

Output: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.


Instruction: Predict the general functional description of the protein sequence.

Output: Cytolytic protein with insecticidal activity. Acts as a pro-inflammatory agent.


Instruction: What is the functional description of the protein sequence?

Input: PGITXTSLHVAPGARLAVKGDIPAGAKSWVINLGKGENDIMLHFNARFDAHGDIRTIV

Output: May regulate cell apoptosis and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: FLPFIAGMAANFLPKIFCAISKKC

Output: Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli.


Instruction: What is the functional description of the protein sequence?

Input: GKFSVFGKILRSIAKVFKGVGKVRKQFKTASDLDKNQ

Output: Disrupts biological membranes, particularly those rich in phosphocholine. Has antimicrobial activity against Gram-negative bacterium E.coli, Gram-positive bacteria B.subtilis and S.aureus, and hemolytic activity against sheep, pig and guinea pig red blood cells. Has insecticidal activity against S.frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides.


Instruction: What is the functional description of the protein sequence?

Input: ADCLNEGDWCADWSGPSCCGEMWCSCPGFGKCRCKK

Output: Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity). Has a potent activity against S.litura larvae.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: PALIPFPRV

Output: Mediates visceral muscle contractile activity (myotropic activity).


Instruction: Predict the functional description of the protein sequence below.

Input: NYLHDTVGRLWGPSRAGLLDGLDWMVGDVQSR

Output: Plasmin-like serine protease. Has fibrinolytic and fibrinogenolytic but not plasminogenolytic activity. Cleaves after Arg and Lys residues.


Instruction: What is the functional description of the protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVKLALVVIFLLLASLFQPLTAQSSCPGNKKETWPELIGVPAKFAREIIQKENSKLTNVPSVLNGSPVTKDFRCERVRLFVNVLDFVVQIPRVG

Output: Stress response. Inhibits trypsin. May play a role in the reentering of protoplasts into the cell cycle.


Instruction: What is the functional description of the protein sequence?

Input: MDILKDKIRSEGIVLSEHVLKVDAFLNHQIDPQLMQQVGHAFAMRFRDQGITKIVTIEASGIAPAVMAGLELGVPVIFARKYQSLTLKDNLYISKVFSFTKQTESTIAISAKHLNAHDHVLVIDDFLANGHAAKALIDLIGQAGASIAGLGIVIEKSFQDGRALLESEGYRVESLARVKSLAGGQVEFLD

Output: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: What is the functional description of the protein sequence?

Output: Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.


Instruction: What is the functional description of the protein sequence?

Output: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.


Instruction: What is the functional description of the protein sequence?

Input: MRAYWFDNLEGDQRQPHDSGRAVDPAYLSKLGVLYHHISSQSEVDELAKARDYKNRDEITVSPEKMGDIYEEKVKSFFHEHLHEDEEIRYILDGAGYFDVRSEGDDWVRIWLEKGDLIILPSGIYHRFTTDEQNYTKAMRLFKDEPKWTPLNRGEETDENQFRQEYLKLRQGLAA

Output: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.


Instruction: Predict the general functional description of the protein sequence.

Output: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: Predict the general functional description of the protein sequence.

Output: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.


Instruction: What is the functional description of the protein sequence?

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: What is the functional description of the protein sequence?

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTTDTHTLHIEEILELLPHRFPFLLVDRVLDFEKGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSAGKLAPGELYYFAAIDEARFKRPVQPGDQMILEVEFIKERRGVARFKGVAKVDGEVACEASMMCARRREA

Output: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the synthesis of GMP from XMP.


Instruction: Predict the functional description of the protein sequence below.

Output: Together with BzaB, probably catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by M.thermoacetica . Requires BzaB for catalytic activity, as BzaA alone displays no activity (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


Instruction: What is the functional description of the protein sequence?

Input: MKLLTVAFSLLLLGQVHASPLVLDKRSSCQLGDVWDLNAADAACSASCAIQHGDKHGGHCDKNKVCVCN

Output: Shows antibacterial activity against numerous Gram-positive bacteria (Probable). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Responsible for energy coupling to the transport system.


Instruction: Predict the functional description of the protein sequence below.

Output: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.


Instruction: Predict the functional description of the protein sequence below.

Output: Cell wall formation.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of lactate to pyruvate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).