Instruction: Predict the functional description of the protein sequence below.

Output: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity).


Protein Function Description

Instruction: Predict the general functional description of the protein sequence.

Output: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


Instruction: Can you provide the functional description of the following protein sequence?

Output: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).


Instruction: Predict the functional description of the protein sequence below.

Input: MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMIVKGSIVRHGDSVTFSITDLGTELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAKHDEKYMPKKYSSSDAAVIGSS

Output: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MWIINWFYDVLSSLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELSIGNVRFTTFDLGGHQQARRLWKDYFPEVNGVVFLVDAKDHERFPEAKAELDALLSMEELSKVPFVVLGNKIDHPDAVSEDELRHQLGMYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGDGIRWLSHFGN

Output: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Probable FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of 5-hydroxy-2-hydroxymethyl-1,4-pyrone, also know as kojic acid, a by-product in the fermentation process of malting rice that acts as a chelation agent . Glucose might be converted to kojic acid by a combination of dehydrogenase and dehydratase reactions involving kojA and probably additional enzymes .


Instruction: What is the functional description of the protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell wall formation.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Insulin-regulated facilitative glucose transporter.


Instruction: Predict the functional description of the protein sequence below.

Input: MLSINLNLIVAFLLALMGVLIYRSHLMSTLLCLEGMMLSLFILMTLLITHFHMFSMSMTPLILLVFSACEAAIGLALLVKISATHGSDHIQNLNLLQC

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.


Instruction: What is the functional description of the protein sequence?

Input: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIDKSLTLGLF

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.


Instruction: Predict the functional description of the protein sequence below.

Output: Mitochondrial DNA endonuclease involved in intron homing.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


Instruction: What is the functional description of the protein sequence?

Output: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.


Instruction: What is the functional description of the protein sequence?

Output: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.


Instruction: Predict the general functional description of the protein sequence.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.


Instruction: Predict the general functional description of the protein sequence.

Output: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.


Instruction: Predict the functional description of the protein sequence below.

Output: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.


Instruction: What is the functional description of the protein sequence?

Output: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.


Instruction: Predict the functional description of the protein sequence below.

Input: MLNKREYYTKEDLLASSRGELFGKNGPTLPAPNMLMMDRVIKMTKNGGNYNKGFIEAELDIQSDMWFFNCHFIKDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVKEVKFTGQILPTSKKVTYFIHFRRIINRKLIMGMADGEVSCDGKIIYTATDLKVGLFKNSTVF

Output: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: What is the functional description of the protein sequence?

Output: Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs. This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: What is the functional description of the protein sequence?

Output: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Acts as a positive regulator of hedgehog signaling and regulates ciliary function.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.


Instruction: Predict the functional description of the protein sequence below.

Output: Proteasome subunit beta type-6; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor . In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB . The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB . The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu . Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B . InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA . The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides . The MFS efflux transporter inpD may contribute to fellutamide resistance as well .


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


Instruction: Predict the general functional description of the protein sequence.

Output: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Essential for recycling GMP and indirectly, cGMP.


Instruction: Predict the functional description of the protein sequence below.

Input: MAIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIASKMVHLSEREAGQFYAVHKERPFFKDLVSFMISGPVMIQVLEGESAIATNRDLMGATDPKKADAGTIRADFAESIDANAVHGSDAPETAAVEIAFFFPGMNVYTR

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.


Instruction: Predict the functional description of the protein sequence below.

Output: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.


Instruction: What is the functional description of the protein sequence?

Output: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAKNTVSARFRKVDVDEYDENKFVDEEEAGEGQQGPDEGEVDSAIRGGNMMGALQAVLKNPPINTKNQSAKDQAEHLVLKVLISFKANEIEKAVQSLDKNSMDLLMKYIYKGFESPSDNSSAVLLQWHEKALAVAGVGSIVRVLTARKTV

Output: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MATQTVENGSRSRPKPTTVGNLLKPLNSEYGKVAPGWGTTPLMGVAMALFAIFLSIILEIYNSSVLLDEISMN

Output: One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.


Instruction: What is the functional description of the protein sequence?

Input: MMLESLARVFKVQLPAYLKRLPIPDSIAGFIRLTVLEWLRLLPFLGVLALLGYLAIRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKKEV

Output: Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


Instruction: What is the functional description of the protein sequence?

Output: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of glycine to tRNA(Gly).


Instruction: Predict the functional description of the protein sequence below.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


Instruction: Predict the general functional description of the protein sequence.

Input: MGAEVFHSLKKVLGEKGLASGVGDEGGFAPNLGSNIRRAGYTAVISHRVAKYNQLLR

Output: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.


Instruction: Predict the general functional description of the protein sequence.

Output: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). MprB/MprA up-regulates expression of mprA and pepD.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the synthesis of activated sulfate.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.


Instruction: What is the functional description of the protein sequence?

Output: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


Instruction: What is the functional description of the protein sequence?

Output: Cell wall formation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Palmitoyltransferase specific for casein kinase 1.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


Instruction: What is the functional description of the protein sequence?

Input: MKIEQTLSIIKPNIISNNFIGNIINRLEQAKLYIIASKMIKLSWKEAVSFYIEHKNKSFFSDLINFMISHPIIVQILEGENAIKRNREIMGNTNPKIALAGTLRSDFSNDIIKNGVHGSDSEESADREIKFFFKKDRIFSRI

Output: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.


Instruction: Predict the general functional description of the protein sequence.

Output: Under iron limitation, RipA negatively controls the expression of the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MLLPDWKIRKEILIEPFSEESLQPAGYDLRVGREAFVKGKLIDVEKEGKVVIPPREYALILTLERIKLPDDVMGDMKIRSSLAREGVIGSFAWVDPGWDGNLTLMLYNASNEPVELRYGERFVQIAFIRLEGPARNPYRGNYQGSTRLAFSKRKKL

Output: Catalyzes the deamination of dCTP to dUTP.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.


Instruction: Predict the functional description of the protein sequence below.

Output: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.


Instruction: Predict the general functional description of the protein sequence.

Input: MKKTALLNAPLSQVIATLGHTDSLTICDAGLPIPKQIERVDLALSAGVPSFLQTFHAVVTEMFVERAIIAEEIKEKNPKILTALLNSLAQLEQQQGNQIEVQYVSHDMFKTYTHASKAIVRSGECSPYANIILYSGVPF

Output: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.


Instruction: What is the functional description of the protein sequence?

Output: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.


Instruction: Predict the functional description of the protein sequence below.

Output: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles, suggesting that it is involved in the minus-end nucleation of microtubule assembly.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.


Instruction: Predict the functional description of the protein sequence below.

Output: Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Tryptophan dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids . The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan . The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan . The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde . The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline . The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine . Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A . Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 . The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions .


Instruction: What is the functional description of the protein sequence?

Output: Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRLSVTALLVTLALCYYEANAIVCPTFAADLTEFFYFPDLLYRLSLAKYNAPPEAVAAKMEVKQCTDRFSVKNRLIITNILGKILLNCTVTDVKAVLNPSSA

Output: May bind androgens and other steroids. May be under transcriptional regulation of steroid hormones (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Involved in the transposition of the insertion sequence IS2.


Instruction: Predict the functional description of the protein sequence below.

Input: MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTERLPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS

Output: This protein regulates the transcription of sigK, which encodes mother cell chamber RNA polymerase sigma-factor (sigma K).


Instruction: Predict the general functional description of the protein sequence.

Input: MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYLAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDSSTEDKKPGERKVKRHAKNN

Output: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MSVTLHTSLGDIKVEIFCDSVPLASENFLALCASNYYNNTIFHRNIKGFMIQGGDPTNTGRGGESIWKKQFKDEFPSHLKHNTRGILSMANSGPDTNGSQFFITYGKHRSLNKVYTVFGKIIAGIEVLDLMEKVPVDDKDLPLNEIILKSVTIHANPIANQ

Output: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


Instruction: Predict the general functional description of the protein sequence.

Output: May be required for pre-mRNA splicing.


Instruction: What is the functional description of the protein sequence?

Input: MGRGRSEIKRIENPTQRQSTFYKRRDGLFKKARELAVLCDADLLLLLFSASGKLYHFLSPTVPSVREFVERYEATTHTKVWADIRQERRAELEKVGSMCDLLEKQLRFMTVDDGEEYTVPSLEALEHNLEAAMRKVRSEKDRKIGGEICYLQNIIRGRQEERYGLCDKIAHAQTLKDVECGSTSLSNGLDLKLGFN

Output: Probable transcription factor.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.


Instruction: Predict the functional description of the protein sequence below.

Input: MGRKDSSNTKLPVDQYRKQIGKQDYKKTKPILRATKLKAEAKKTAIGIKEVGLMLAAILALLLAFYAFFYLRLSTNIDSDLDLDED

Output: May play a role in cell growth and maintenance of cell morphology.


Instruction: What is the functional description of the protein sequence?

Input: MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILGALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLTLCGSLFAFWCGWTITI

Output: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.


Instruction: Predict the general functional description of the protein sequence.

Input: MNRSFHFLIKYIYIHVLLVFYFHIKQQAIMPFFIFFFSSFDGLSFDLRVVAFLAKHVFVGVCSPFFVVGFFGSSRVVVTEWLSKLVLPPPPVSITQVFSLSRKRGEFSSGYILIINPYKSFLRSLLDFSIFNNTAKNKSSTFTLNLEDVSK

Output: May be involved in cell wall organization and biogenesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSTLLYLHGFNSSPRSAKASLLKNWLAEHHPDVEMIIPQLPPYPSDAAELLESIVLEHGGDSLGIVGSSLGGYYATWLSQCFMLPAVVVNPAVRPFELLTDYLGQNENPYTGQQYVLESRHIYDLKVMQIDPLEAPDLIWLLQQTGDEVLDYRQAVAYYASCRQTVIEGGNHAFTGFEDYFNPIVDFLGLHHL

Output: Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHLKNSGRSR

Output: Absolutely required for transposition of IS1.


Instruction: What is the functional description of the protein sequence?

Output: Essential for F plasmid conjugative transfer, participates in F-pilus assembly.


Instruction: Predict the general functional description of the protein sequence.

Input: MEGRKSEDEKNEAALACDVFESSNAKLPKNVFRSSFTWYCYEVINRSAFHIWLLLCLTLIVGWKVFSGIGGRRPSDSNMDGPQTKHKRNPGFLRRHSTIVILVISLAVSFSWEAFKMYRERTFGKQITQFAKEIIKSAPSTDMESWDRVAADFNSYMYENKLWNTEYFFC

Output: May be involved in cell wall organization and biogenesis.


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.


Instruction: What is the functional description of the protein sequence?

Output: Forms chloride channels.


Instruction: What is the functional description of the protein sequence?

Output: Sugar transporter.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MPKHEFSVDMTCEGCSNAVTRVLNKLGGVQFDIDLPNKKVCINSEHSVDTLLETLGKTGKAVSYLGPK

Output: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: May act as a low affinity receptor for acetylcholine.


Instruction: Predict the general functional description of the protein sequence.

Output: Converts protoheme IX and farnesyl diphosphate to heme O.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: May be required for pre-mRNA splicing.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLIYKDIFTDDELSSDSFPMKLVDDLVYEFKGKHVVRKEGEIVLAGSNPSAEEGAEDDGSDEHVERGIDIVLNHKLVEMNCYEDASMFKAYIKKFMKNVIDHMEKNNRDKADVDAFKKKIQGWVVSLLAKDRFKNLAFFIGERAAEGAENGQVAIIEYRDVDGTEVPTLMLVKEAIIEEKC

Output: Involved in calcium binding and microtubule stabilization.


Instruction: Predict the general functional description of the protein sequence.

Output: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSTSSCSFKDRRVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFIGRCYFTEICKCKLKDIACLKCGNIVGYHVIVPCCSCLLSCNNGHFWMFHSQAVYGINRLDSTGVNFLLWGNLPEVEENTDEDMLDISAEECIR

Output: May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MSQTENAVTSSSGNKRAYRKGNPVPARERQRASLARRSNTHKAFHAVIQARLKDRLSELADEEGITQAQMLEKLIESELKRRATL

Output: This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA.


Instruction: What is the functional description of the protein sequence?

Output: Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.


Instruction: Predict the functional description of the protein sequence below.

Input: MASSSMSSSSSWTSKQNKMFERALAVYDKDTPDRWQNVAKAVGSKSAEEVKRHYDILVEDLMNIEQDLVPLPKYKTVDVGSKSRGIDDFDLRLMKNMRIQ

Output: Probable transcription factor.


Instruction: What is the functional description of the protein sequence?

Output: May be involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner.


Instruction: Predict the general functional description of the protein sequence.

Output: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Probable mitochondrial adenylate carrier that catalyzes the transport of ATP, ADP and AMP.


Instruction: What is the functional description of the protein sequence?

Output: Required for normal meiosis.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the transposition of the insertion sequence IS5.


Instruction: What is the functional description of the protein sequence?

Input: MLRPPPPSSVLTASAAAARPPASVVQPQRQAAHRRRAETLRLRRVFEMFDRDGDGVITPAELSGALCRLGARGEAPPAAAALDAVVAAYIAPGMAGLRFAEFEALHAELAGLGGRQAVAAAEAEEEKEADMREAFGVFDEDGDGYISAAELQAVLSRMGLPEAACMARVRDMIAAADRDSDGRVDYEEFKAMMAAGN

Output: Potential calcium sensor.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVSLLFCGPKLAACGLVLSIWGVIMLALLGIFFTTHSAILIEDVPLTEEDLHSQDTPPQSVYKLYNQVGYNCFIAAVIYVGIGFLSFCQVRLNKRKEYLVH

Output: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MATVVLGGDTMGPERIFPNQTEELGPHQGPTEGTGDWSSEEPEEEQEETGAGPAGYSYQPLNQDPEQEEVELAPVGDGEDVVADIQDRIQALGLHLPDPPVESEDEDEQGATALNNHSSIPMDPEHVELVKRTMAGISLPAPGVPAWARELSDAQWEDVVQKALQARQAAPAWK

Output: May play an important role in spermatogenesis and/or testis development.


Instruction: Predict the general functional description of the protein sequence.

Input: MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS

Output: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in fertilization ability of sperm.


Instruction: What is the functional description of the protein sequence?

Output: May have hydrolase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSHIRLTQVLIHNNPSSFNSPFIFDISFECVSPIKEDLEWKVIYVGSADNEKNDQVLDSILLGPVAVGQNQFVFEVDPPDANKIPKDDLLGVTVVFLICAYKGEDFIRVGYYVNNDYFEQELKDNPPETPDLSKIQRNVMDDKPVVTGFPIQWN

Output: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MCGDCVEKEYPNRGTTCLENGSFLLNFAGCAVCSKRDFMLITNRSLKEEDGEEIVTYDHLCKNCHHVVARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF

Output: Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: May function as sodium-coupled metabolite transporter across the chloroplast envelope.


Instruction: What is the functional description of the protein sequence?

Input: MMKFMCICLCAISAVSANSYGRSRGGYGGAPVGGYAYQVQPALTVKAIVPSYGGGYGGNHGGYGGAYESVPVPVSSAYSGANVGSQYSGSGYGGAPPVDAQAIALAKLALAAPSAGAPLVWKEAPRYAQPVYPPTSYVNQEYGHSEKVKGGSAAAAASSVAAGKKGYKRPSY

Output: Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in the germinative response to L-alanine. Could be an amino acid transporter. Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSYGGSASQDIVTKLIRKIQNTSVSCTRRDENLDSFNQHLKMSLKVAHNTKTFAKHCLHRQVFKNTYRKRKAVEDQRKNLNTQLRQKFASPSDNLLSPCSRKLNDHKSKLFSAKSQPKTLEFVRGKQNIPRKPNVDI

Output: Component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase and is required for the efficient segregation of telomeric and nucleolar regions. Although BNS1 can partially compensate for a lack of SPO12 function when overexpressed, it does not appear to play any role in controlling meiotic nuclear division.


Instruction: Predict the general functional description of the protein sequence.

Output: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAFTLYSLLQAALLCVNAIAVLHEERFLKNIGWGTDQGIGGFGEEPGIKSQLMNLIRSVRTVMRVPLIIVNSIAIVLLLLFG

Output: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: May be involved in transcriptional regulation.


Instruction: Predict the general functional description of the protein sequence.

Output: Cysteine hydrolase.


Instruction: Predict the general functional description of the protein sequence.

Output: Formins play an important role in the nucleation of actin and the formation of linear actin filaments.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MGKRKSAAKPPPKKRMDKLDTVFSCPFCNHGSSVECRIDMKNLIGEASCRICQENFSTTVNALTEPIDIYSEWIDECERVNNVEDDDGA

Output: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.


Instruction: Predict the general functional description of the protein sequence.

Output: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MEAKTFAFLEIAMFIALGIQTFVAVTDAAGKDDEHFSVDYCGMNCTQQEDGSWTACSGRNGECRCYHESGKRSGLCLSTTYIDFSEYGNLSDSDIAAASPRLSMKESH

Output: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8.


Instruction: Predict the functional description of the protein sequence below.

Output: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARVKRALNAQKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAAGVEVDRKNLAELAVSDPAAFTALVDVARAALPEDVNAPSGEAA

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MNALLLLAALSSQITFNTTQQGDMYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS

Output: Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers mannobiose over mannotriose and has no activity against polymeric mannan. Is also severely restricted by galactosyl substitutions at the +1 subsite (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPNRRRV

Output: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield the diacylated intermediate 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278).


Instruction: Predict the general functional description of the protein sequence.

Input: MSKVAVLLRVLPDDAETKPEELYKKIAAALPEKYQVAQYQAEPIAFGLEALRMVILMPEETEGGTEELETIIQSVQGVSQVDVLNVTRFSG

Output: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).


Instruction: Predict the general functional description of the protein sequence.

Input: MQISIFAVGRMKVGAEQELVHRYLDRFSKSAGAVGLHFRKMQEVSESRAQTACQRMEEEGKRLFEALPEPSRLIVCDERGKSVSSIAFAEKLAFYRDEGVRDLVIALGGPDGHSEQVRDRADFLLSFGLMTWPHQIARILLTEQLYRTVTIANNHPYHRF

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MRYAGTAHKVGDHIDTDAIIPARFLVTTDAQKLGENCMEGLEHGWVARVKSGDIMVGGRNFGCGSSREHAPIAILGAGMPVVVAHSFARIFYRNGFNMGLLLLEVGDDVDKIADGDDIEVDAASGVITNRTTGATITCAPVPQSMRELLDTGGLVPYVRARLERENG

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: What is the functional description of the protein sequence?

Output: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.


Instruction: What is the functional description of the protein sequence?

Input: MPRVKRGVTARARHKKVLELAKGFRGRRKNVYRIAKQAVMKAGQYAYRDRRNRKRVFRRLWIARINAASRSHGITYSRFIAGIKKAAIDIDRKMLAELAVNDPAAFGSIVEKVKAQLA

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLDSLKQKKNFQRIKMRIKTGDLVKVINGKEKGKTGEVLKTIPLENRVVVKGINLRTKHVKPTQEGETGRILTEEASLHASNVMFFSKEKNLTSKIEYFIDKEGVKKRRLKKTGEVID

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: What is the functional description of the protein sequence?

Input: MSYKFPDNLNYADTHEYVLEENGLLKIGVSEFAIDQLGDIVFVELADEGATLEKGETFGTIESVKAVEEVYLPFSGEIVSVNESVIENPELLQSDPIGDGWLVILKPESKASIADLMTSEEYQSKVVPK

Output: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Instruction: Predict the general functional description of the protein sequence.

Input: MKKLSILAVLAASPAMAATGPFLSLSNTNFIVTLAFLIFMGILLYAKVPGRVLGMLDKRSVQIRTELEEARALREEARTILASYDRKQKEVQEQAARIVASARDEAQAAAEQAKADLRASIARRLAAAEDQIASAEAGAVRAIREQAVSVAVAAAADLLSRQMTPAAASASIDESIKEVEARFH

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQILYRAMKNIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPVEIGSAQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.


Instruction: Predict the functional description of the protein sequence below.

Output: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSGLVPIVVEQTNRGERAYDIYSRLLKDRIIFIGGPIDDHIANLVIAQFLFLEAEDPEKDIHLYINSPGGVVTAGLAIYDTMQYIKPAVSTICLGQAASMGSFLLAAGAPGKRYALPMARIMIHQPLGGVQGQATDIDIHAKEILRMKDLLNDRLAHHTGQPLEQITRDTERDYFMSAEEAKKYGLIDEVMPYRK

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Predict the functional description of the protein sequence below.

Output: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


Instruction: What is the functional description of the protein sequence?

Input: MPTITSYFGFLLAALTITSVLFIGLSKIRLI

Output: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.


Instruction: Predict the functional description of the protein sequence below.

Input: MTYHLDVVSAEKKMFSGVVQKIQVTGSEGELGIFPGHAPLLTAIKPGMIRIVKQFGEEEFIYLSGGILEVQPSVVIVLADTAIRGLDLDEARALESKRKAEAHINNSHGDVDYAQASAELAKAIAKLRVIELTKKAM

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: What is the functional description of the protein sequence?

Input: MPPKKKLVKTFTLQLPAGQATPAPPVGPALGQHGVNIMEFCKSYNAQTESQRGDIVPAEISVYEDRTFTFVLKTPPAARLLIKAAGVAKGSGVPHMEKVGQVSRAQLREIAEKKMADLNANDLDQAEKIIAGTARSMGLNVVD

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.


Instruction: Predict the general functional description of the protein sequence.

Output: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSLRLQEKYEKEVVPALMDKFGYKNIMQAPKLEKIVINMGVGEAKDNPKVLESAVNDLTIITGQKPVLTRAKKSIANFKLRENMAIGCKVTLRKQYMYEFADKLMNVALPRVRDFSGVSDKSFDGRGNYSLGIKEQLIFPEIEYDKIDKVRGMDIVFVTTANTDEEAKELLRLFGMPFAQK

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the transfer of the first rhamnosyl residue on p-hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O-methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (also called mycoside B) during p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.


Instruction: What is the functional description of the protein sequence?

Input: MDSYSIIIKPHVTEKTMNLIDKNNEITFVVKRDANKGQIKRAFEELYEEKVARVTTHITPRGNKVAFIKLVEEEMAEELAVKIGVF

Output: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Acts as a chaperone.


Instruction: Predict the functional description of the protein sequence below.

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: What is the functional description of the protein sequence?

Input: MSRIGKLPIHVPAGVTVTIKDNVVTVKGPKGELVQEVNPDINVTLEDGVIHLTRPTDDKNHRALHGLYRSLINNMVVGCSEGYKKELELVGVGYRVSNTGQLLDLSLGYTHNIYLQLPKEVKVETKSERNKNPLIILESADKQLLGQICAKIRSFRMPEPYKGKGIKFVGEEIRRKSGKSAGK

Output: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.


Instruction: Predict the general functional description of the protein sequence.

Input: MRILGLDLGSKTIGVAVSDPLGFTAQGLTTVRRTNKEKDIAEIKKFCDEYDAKVIVIGLPKNMNGTIGPSGEIAMAFGKVIEEELNVEVKFWDERLTTVAAHKAMLEADLSRNKRKKIVDKVASTYILQGYLDMISRK

Output: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN

Output: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRVKTGTVRRRRHKKILKQAKGFYSGRRKHFRKAKEQLERSLVYAYRDRKQKKREFRKLWITRINAACRLNDISYSRFIHGLSKAGIELDRKILADMAMNEPEAFKAVVEKAKAAL

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSDIINETKSRMQKSIESLSRELANISAGRANSNLLNGVTVDYYGAPTPVQQLASINVPEARLLVISPYDKTSVADIEKAIIAANLGVNPTSDGEVIRIAVPALTEERRKERVKDVKKIGEEAKVSVRNIRRDMNDQLKKDEKNGDITEDELRSGTEDVQKATDNSIKEIDQMIADKEKDIMSV

Output: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.


Instruction: Predict the functional description of the protein sequence below.

Input: MKTFSAKGHEVQRDWFVIDATDKVLGRVASEVALRLRGKHKPEFTPHVDTGDFIVVINAGKLRVTGTKATEKTYYRHSGYPGGIYETNFLKMQQRFPGRALEKAVKGMLPKGPLGYAMIKKLKVYAEATHPHAAQQPKALEL

Output: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.


Instruction: Predict the functional description of the protein sequence below.

Output: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSDSDAMTDPNAVSYSNAIVVLCTAPDEASAQNLAAQVLGEKLAACVTLLPGATSLYYWEGKLEQEYEVQLLFKSNTDHQQALLTYIKQHHPYQTPELLVLPVRDGDKDYLSWLNASLL

Output: Involved in resistance toward heavy metals.


Instruction: Predict the general functional description of the protein sequence.

Input: MQVNIFYIQKSDEFKTWSEKYSKLISKYGTLKEINVFNKKIALAQNLNAIEAKKSYEEAFMPYKKGYCIALDERGKDLTSIEFAKLIQDKNELSFFIGGAYGLREEFNQSLDFRLSLSKLTLAHQFVKTLLLEQIYRAFCINNNHPYHK

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARVKTGVVRRRRHKKVLKLARGFFSARRKHFRKAKEQVERSLVYSYRDRRNKKRDFRRLWIVRINAACRLNDISYSKFINALKKANIELDRKVLADLAMNDAAAFSAIVAQAKKVM

Output: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: What is the functional description of the protein sequence?

Output: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


Instruction: Predict the general functional description of the protein sequence.

Input: MSDDVALPLQFTEAAAKKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGAVDYTEGLEGSRFVVTNPNAKSTCGCGSSFSI

Output: Required for insertion of 4Fe-4S clusters for at least IspG.


Instruction: Predict the functional description of the protein sequence below.

Input: MSKEKEVLLNEEIRADEIRCVGDDGKVYGIISSDEALEIANRLGLDLVMIAADAKPPVCKIMDYGKFRYQQEKKQKEAKKKQKVIDIKEIKLSVKIAQNDINYKVKHALEFLEQGKHVRFRVFLKGREMATPEAGVALLEKIWTMIENEANRDKEPNFEGRYVNMLVTPKKA

Output: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRSAKLKFEKRRSRIRHKISKTSNRVRLSIFKSCRHIYAQIIDDSRSITIASASTLDEKITTLKKSYCNIDNAIKVGEAIAKKADSAGIKEVVFDRGGYKYHGVVKALADAAREKIKF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: Predict the general functional description of the protein sequence.

Output: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


Instruction: Predict the general functional description of the protein sequence.

Input: MAAMTVQLDMVSAENHIFSGRVAQLQVSGTEGELGIMPGHAALLTSIKPGMARIVKQNGSEEVFYLSGGILEVQPSSISVLADVVLRADEIDEQAAAEAKLRAETAMAGAGADFNYAAAAVELAQAIAQLRVVETIKKNIAR

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Predict the functional description of the protein sequence below.

Input: MMTDPIADMLTRIRNAALARHDRTEVPASRIKAAVAEILKSEGFIADVRETEGEGPKKLTIVLKYGRDRQSAIDGVRRVSRPGRRVYVRHDRIPRVFSGLGISILSTSRGLMSDRDARRLKMGGELICEVW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: What is the functional description of the protein sequence?

Output: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


Instruction: What is the functional description of the protein sequence?

Input: MASLIQVRDLLALRGRMEATQISHTLHAPQPMIDAMLNQLEIMGKAVRIPEEPDGCLSGSCKSCPEGKACLREWWALR

Output: May function as a transcriptional regulator that controls feoABC expression.


Instruction: Can you provide the functional description of the following protein sequence?

Output: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.;


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKVLLLQDVEHLGKAGEIKDVSGGFGRNYLLPKGFAVLATKSQVKQAEERLAAQRRKAEAARKEAEALAARLAELTLTFTVKVGEQDRLYGSVTNADIAAKLHEVAGIEIDRRKIGLEDPIKRTGEYEVPVELMSGVSSTLKVVVVGE

Output: Binds to the 23S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.


Instruction: What is the functional description of the protein sequence?

Input: MVPRLKSKYEKEIRPTLQKSLGFQSVMRVPKLEKIVINVGMGEAHTNPKAMEACLVEIGQITGQRPVKTFAKKSIAGFKVREGMVLGCKVTLRGHHMYEFLDRFINVALPRVRDFRGVNPKGFDGRGNYNLSVREQIIFPEIQFDKINTIYGINITFVTNTEVDKEAFELFQAFGMPYRTAGK

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MNLENVILSPVVTEKSQDLQTIGERMGKRTVKYTFKVHPDANKTLIKQALKQMYNVVPTNVNVAVYRGKMKRFRNMPSQRPHYKKAVVTFADGANLDFAKV

Output: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.


Instruction: Predict the general functional description of the protein sequence.

Input: MRLILLSGLLLLGIFLANGDEVDPDRKLLNSLIDALMHLQREFANLKGSFLIVHKARSFGSGSERMYVTNKEIKNFEALRQICEQADGHIPSPQLENQNKAFANVLERHGKEAYLVVGDSANFTNWAAGEPNKAAGACVKADTHGSWHSASCDDNLLVVCEFYFIL

Output: This phospholipase A2 inhibitor binds directly phospholipase A2 in the presence or absence of calcium.


Instruction: Predict the functional description of the protein sequence below.

Input: MPTISQLIRRGRETVAQKSASPALRECPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGYEVTTYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDTAGVQNRNRGRSKYGAKRPKK

Output: With S4 and S5 plays an important role in translational accuracy.;


Instruction: Predict the functional description of the protein sequence below.

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPKKAASPEIKAASFETSLSELEQIVTRLESGELPLEDALNEFERGVQLVRQGQQTLLQAEQRVQILLSDDVDAPLKPFTPDTE

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKPGIHPEYAEITATCTCGNVIKVNSTAGKSLHLDVCGACHPFYTGTQKIVDTGGRIDKFNKRFGALGKK

Output: Binds the 23S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MAKKVVGMIKLQLPAGKASPAPPVGPALGQHGVNIMGFCKEFNAKTANQAGLIIPVVITVYQDRSFSFILKTPPAAVLLKKAAGIESGSGVPNKTKVAKVTKDQIREIAETKMPDLNAGSIETAMSMIAGTARSMGITVEE

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.


Instruction: What is the functional description of the protein sequence?

Input: MFAIIRTGGKQLRVSEGQEIFVEKLPINPEQNYEFKEVLAVYGEKSILGQPYVEGAKVQAQVIKNDRAKKIIVFKYKRRKKYRCKQGHRQAYTKLLITKIIA

Output: This protein binds to 23S rRNA in the presence of protein L20.