Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Protein Function Description

Instruction: Predict the general functional description of the protein sequence.

Input: MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIRRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGNFKPHLQKLCDGINKMLDEENI

Output: Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MQDVETYLSTAPVLATLWFGFLAGLLIEINRFFPDALVFPSL

Output: May help in the organization of the PsaE and PsaF subunits.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MVALESAHLVGAGGALGALCRHYLAGAIQRETFPLGTLTVNAFGSFALGLLTFAGVTGDAALLVGVGACGSFTTFSSFSVETVRLWENGYVALAALNAVGNLACALVGIGLAWGIVRIV

Output: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRHYEIMFLVHPDQSEQVPGMVERYEGIITKHNGKIHRKEDLGRRQLAYSINKVHKAHYILMNVECNLDALNEIKNAFKFNDAILRHLITVQKQAITTESVLMKKEKETKVA

Output: Binds together with S18 to 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Involved in phosphonate degradation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible oxidation of malate to oxaloacetate.


Instruction: What is the functional description of the protein sequence?

Input: MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGGAAAGGAAEEKTEFDLVLAGAGDQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIAKEEAEELKAKLEEVGASVEVK

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.


Instruction: Predict the general functional description of the protein sequence.

Input: MLSYCLLVTGPAYGTQQASSALQFAQALLAEGHKLESVFFYREGVLNANQLTSPANDEFDLVRGWQQLGDVHQVALNVCVAAALRRGIADSQQATQLNLVGANLQPGFILSGLGELAQSVLTYDRVIQF

Output: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAKKSLIQREKKRHKLEQKYHLIRRSSKKKIRSKVSPLSLSEKTKMQEKLQSLPRNSAPTRLHRRCFLTGRPRANYRDFGLSGHILREMVYACLLPGATRSSW

Output: Binds 16S rRNA, required for the assembly of 30S particles.


Instruction: What is the functional description of the protein sequence?

Input: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE

Output: One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTSKTVTRADLASVVCRKVGLSHTESAALVELVLNEICNSLVRGEAVKLSSFATFQVRKKNERVGRNPKTGVEAPILPRRVVTFKAANVLKQRILDSHRARQKIISHE

Output: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.


Instruction: Predict the functional description of the protein sequence below.

Input: MYQLQFINLVYDTTKLTHLEQTNINLFIGNWSNHQLQKSICIRHGDDTSHNQYHILFIDTAHQRIKFSSIDNEEIIYILDYDDTQHILMQTSSKQGIGTSRPIVYERLV

Output: Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme. Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B. Also involved in growth capacity, viability and bacterial morphology (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MLNRVVLVGRLTKDPEYRTTPSGVSVATFTLAVNRTFTNAQGEREADFINCVVFRRQADNVNNYLSKGSLAGVDGRLQSRNYENQEGRRVFVTEVVCDSVQFLEPKNAQQNGGQRQQNEFQDYGQGFGGQQSGQNNSYNNSSNTKQSDNPFANANGPIDISDDDLPF

Output: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


Instruction: What is the functional description of the protein sequence?

Output: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MALLEFFRPKKTTTASVAKERLQIIVAERRSAGQSTPSYLPQLKLDLLEVIRKYVNINPDQVSVNLDQKDEDLSVLELNVTLPEDK

Output: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAAKIRRNDEVIVLTGKDKGKKGKITKVLATGKVIVEGINLVKKHQKPVPAMGVQGGIVEQEAAIDVSNVAIFNAETGKADRVGFRFEDDKKVRFFKSNSVTIK

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAQMSTSEIRGGVKVEVEAQPYTIISNEFVKPGKGQAFNRIKMKHLLTGRVIERTFKSGEKLNLADVAEEEMRMLYKESDGVIFMDEKSFEQIKISLESIGETVQWLLDDHVYEVIFYNGNAVNVEPPTFMEMVITDTSPGVRGDTASGRVLKPAILESGAKVQVPIFVEQGEKIKVDTRTGEYVSRVSS

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MINQANKTAKLRVKRAVRVRKHLRGTGLKPRLCVVKSNSHIQAQLIDDETGTTLGGTATFAKEYRNTEFCKKNKASARKLGEQIAEIAKSKNIKEVVFDRGPFKYHGILAELANAARAGGLQF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: What is the functional description of the protein sequence?

Input: MIIGIGSDLIDITRIAKVIERHGERFLDRVFTEAERAKAERRAKKSELVAATYAKRFAAKEACSKALGTGIRQGVWWRDMGVVNLPGGRPTMVLTGGAKTRLDALTPPGMTARIDLSITDEWPLAQAFVVISAIPAAAEQAVHTSS

Output: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: DNA helicase which seems to act as a postreplicative transcription termination factor. Involved in ATP-dependent release of nascent RNA. Forms a stable complex with single-stranded DNA, and to a lesser extent RNA (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


Instruction: Predict the functional description of the protein sequence below.

Input: MSNSISVSFNDEPPGSIDPVRVENFISEVLKDLNLKNWDISLLFCDDAFIQNLNKQYRDIDSPTDVLSFEQGDEYFDEAGETRFMAGDIVISLDSLSFNAEEFNVDINEELKRLIVHGILHLNGMDHSDNSPEQEMLKFQEELLMQYKNMEIYRV

Output: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MSQRGNRKTQVGVVVSDKMDKTVVVRVSHLVKHPVYNKYIKRSVKYKAHDTDNSCKTGDRVLIVETRPLSKDKRWKVRQIIDRVE

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Structural protein that forms a matrix surrounding the mature virion (MV) through interaction with protein A26. Presence of protein A25 in the virion structurally prevents direct virus-cell fusion mechanism (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MHCPFCSENDTKVIDSRLVADGHQVRRRRQCLACNERFTTFETAELLMPKVIKSNGNREPFNEDKMVGGIQRALEKRPVSADAIELAISMIKSKLRATGEREVPSKMIGNLVMEQLKHLDKVAYIRFASVYRSFEDIREFGEEIARLED

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Predict the functional description of the protein sequence below.

Output: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.


Instruction: Predict the general functional description of the protein sequence.

Input: MRHYEIVFIVHPDQSEQVPAMIERYKGMVLAAEGKIHRLEDWGRRQLAYPIQKLHKAHYVLMNVECQAETLAEIEHAFKFNDAVLRHLTIKMDRAISDASPMMKDEKAKNLLDAQPAAEVEASA

Output: Binds together with S18 to 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.


Instruction: What is the functional description of the protein sequence?

Input: MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAKTQGMEPGLPIPVVITAFADKSFTFIMKTPPATVLIKKASGVQKGSAKPHTDKVGTLTRAQAEEIAKTKQPDLTAADLDAAVRTIAGSARSMGITVEGV

Output: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


Instruction: Predict the general functional description of the protein sequence.

Output: Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.


Instruction: What is the functional description of the protein sequence?

Output: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: What is the functional description of the protein sequence?

Input: MEALVYTFLLVATLGIIFFAIFFREPPKVPNRGK

Output: Seems to play a role in the dimerization of PSII.


Instruction: What is the functional description of the protein sequence?

Input: MKYQQLENLECGWKWKYLIKKWKDGEAITRHIDTSEADAAIAELRRIEHEPTLVLAWIEKHMSEELENKLKQAIRAKRKRHFNAEQVHTKKKSIDLDYRVWEKLSNRANELGCTLSDAIEYLLSEASRSEKASQKVTSIKEDLSKLLSS

Output: Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.


Instruction: Predict the general functional description of the protein sequence.

Output: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


Instruction: Predict the general functional description of the protein sequence.

Output: Necessary for normal cell division and for the maintenance of normal septation.


Instruction: Predict the functional description of the protein sequence below.

Input: MISKPDKNKTRQRRHARVRGKISGTAERPRLNVYRSNKNIYAQVIDDVEGVTLASASTLDSEVKGNNKTEKAASVGEVVAKRAAEKKIVDVVFDRGGYLYHGRVQALAEAARENGLKF

Output: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTANRKELAVERAAKKEAVEQLNGVFKTTSVAVVAQYSGLTVAQMQKLRQQMKQAGASVKVSKNRLAKIALEGTDVVAIGPMLKGPTVIATSNDPVAAPKVAIEFAKANEKFVIVGGSMGKTVLNVDGVKALASLPSLDELRGKIVGLIVAPATKLAQLANAPAGKLARVIQAHASKGEAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Predict the functional description of the protein sequence below.

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: What is the functional description of the protein sequence?

Output: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.


Instruction: Predict the general functional description of the protein sequence.

Input: MTVEKSYYMTQEGKDKLEEELHYLKTDRRQEVVERIKVARDFGDLSENSEYDAAKDEQAFVEQRITQVEKMIRNAVIIENDNDNPNIVSLGKSVSFVELPDGDEETYTIVGSAEADPFEGKISNDSPMATSLLGKEIGEEVTVTTPGGDIDVRITNVE

Output: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


Instruction: What is the functional description of the protein sequence?

Input: MFKKLDPSPKWIVYDNNPVMHKPIEDVVFPLTKEDEHVISQMLSYVDASYEGEADKYDIRAGIGIAAIQLGCPKKIIYIHLDDKNGEHKYLMANPKIIKESTSKMYLKNGEGCLSVKKDHKGLSIRKSIVWVKGIDLFTNKEIEVKATDLLAACFQHEVDHNNNKFYYNRINESDPYYVEKNWEEI

Output: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSLALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH

Output: Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons.


Instruction: Predict the general functional description of the protein sequence.

Output: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: What is the functional description of the protein sequence?

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Predict the general functional description of the protein sequence.

Input: MGGRGMNPAKMKQMMKQMGIDVKELKDVKEVIIKTADSNIVIENANVTIMTVQGSETYQIVGDAKEVPKSLEIPADDIKLVMEQTGVSEEEARNALKNSNGDLAEAIVALSSA

Output: Contacts the emerging nascent chain on the ribosome.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds directly to 23S rRNA. Probably involved in E site tRNA release.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTKESLEKATFAGGCFWCMVKPFDTQPGIEKVVSGYTGGHTVNPTYKEVCSGTTGHTEAIQITFDPAVFPYEKLVEVYWQQTDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAALDASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEGYQVASGRAAFIDANWKG

Output: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Predict the functional description of the protein sequence below.

Output: Specifically methylates guanosine-37 in various tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.


Instruction: What is the functional description of the protein sequence?

Output: Efflux system for nickel and cobalt.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


Instruction: What is the functional description of the protein sequence?

Input: MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQEAQIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIETKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKVAVQASAENQELEEAMEAMLALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK

Output: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MLKEFQEFISKGNVMDLAVGVIIGAAFGKIVDSLVNDIIMPVIGAIFGGLDFNNYFVGLSSAVNATSLADAKKQGAVFAYGSFITVALNFVILAFIIFLMVKAVNNLRRRLEREKPATPAAPPPADVALLTEIRDLLARR

Output: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.


Instruction: What is the functional description of the protein sequence?

Input: MMPFSREERQFVYTWLSNMLGHELSASQLAQYQQGLFDDFFAFLTEQGFQAQVEGIQQQLQQLKTVELAHLELAADYTQLFLLDGSSSALPYASVYLPEAQLTCHFTFLEALLVRFQLQLNRDKPEPSDHLCVYLELLRQLAEVDDMKTYRQLIQDALLPWLLPFNDKVQRVKTRTTFYQQVVVLLILLLQADCQN

Output: Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Polymerizes into bundles of filaments, forming a helix with a filament width of 5.5 nm and an axial repeating unit of 5.5 nm. Polymerization of Ta0583 requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction. Nucleoside diphosphate or AMP-PNP does not support polymerization.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MGTETATLGGGCFWCTEAAMEELAGVTDVTSGYAGGDTADPSYRDVCSGTTGHAEVVQVEYDTAELAYEDVLEVFFTVHDPTTVDREGPDVGSQYRSIVLPHDDQQHERATAFVDELAAADAFDGSIVTEIEPLETFYPAAEKHQNYFEKNPDAAYCTVNVAPKVSKVREQFGARTE

Output: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Output: Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of toxin ParE (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Acts as a chaperone.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.


Instruction: Predict the general functional description of the protein sequence.

Output: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTTTEKVQPRLKERYRNEIRDSLQQQFGYANVMQIPTVTKVVVNMGIGEAARDAKLINGAVNDLALITGQRPEIRRARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQSVFHEIDVDKIDRVRGMDINVVTSATTDDEGRALLRALGFPFKEN

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.


Instruction: What is the functional description of the protein sequence?

Input: MPKGKNLHVKIGDNVKIISGFDKNKTGEVTKIYRNTGKILVKGINFKFKHIKPNTESDVGEIKQFEAPIHHSNVKLI

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: What is the functional description of the protein sequence?

Input: MTEYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAIGMGLATTFVLTLASVCAWMVNSFILLPLGLVYLRTLAFILVIAVVVQFTELVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINQSHNFMQSAVYGFSAAAGFSLVMVLFAAIRERLAVADVPAPFRGSSIALITAGLMSLAFMGFTGLVKF

Output: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSRIITAPHIGIEKLSAISLEELSCGLPERYALPPDGHPVEPHLERLYPTAQSKRSLWDFASPGYTFHGLHRAQDYRRELDTLQSLLTTSQSSELQAAAALLKCQQDDDRLLQIILNLLHKV

Output: Required for Yop secretion.


Instruction: Predict the general functional description of the protein sequence.

Output: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


Instruction: Predict the general functional description of the protein sequence.

Output: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.


Instruction: What is the functional description of the protein sequence?

Output: Endoribonuclease that initiates mRNA decay.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: Predict the functional description of the protein sequence below.

Output: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: MAKTATPGACASDPGSGPLPENYEMALAELEALVARMEGGTLSLEDSLAAYRRGAALVAFCQQQLEKAEQQVRVLDGASLKPLSAGTAAADGEDDDL

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the general functional description of the protein sequence.

Output: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.


Instruction: Predict the functional description of the protein sequence below.

Output: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MARFQEFYKEKVVPGLIEKFGYKSVMEVPRITKITLNMGLGEAVADKKIIENAVGDLTKIAGQKPVVTKARKAIAGFKIRQGYPIGAMVTLRGRAMYEFLDRFVTVALPRVRDFRGVSGRAFDGRGNYNIGVKEQIIFPEIDYDKIDALRGLNISITTTAKTDDEAKALLASFKFPFRN

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May be involved in recombination.


Instruction: Predict the functional description of the protein sequence below.

Output: Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MGRTLENKQQIVTEIKSLLNDSEMAVVLDYKGLTIKEMSDLRSRLQTTNGICKVTKNSLMRKAIDGDSNWNDLESLLTGTNAFVLIKEDVGGAVKAIQSFQKDTKKSETKGALFEGRLLSDSEIKEIASLPSKEVLMAKIAGALNGVATKIAISINEVPSGLARSLKQHSEKSES

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTKTDRVCVGAIAGAFGVKGEVRLKSFCTEPTDIASYGPLSTEKGDRSFRVTLTRPVAGGLGARLSDVTTKEEADALRGVGLYVDRARLPSLGDDEFYHADLIGLEVRDTGGALLGRVHAVHNHGAGDILEIAGAVGREGLLLPFTRAVVPTVDLAAGRIVADPPEGLD

Output: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.


Instruction: Predict the functional description of the protein sequence below.

Output: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.


Instruction: What is the functional description of the protein sequence?

Input: MKFLLLVLAALRFLTQVIPASAGGSKCVSNTPGYCRTYCHQGETALFMCNASRKCCVSYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS

Output: Has antibacterial activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKNCMMADQRGRSILKHQPVVGDEALEFSRGLAPSTFGFRYAAYMDRNHFLPSGRTAVKHIADPTLAYVMTRYRQCHDFVHIITGCGRSIEEELAVKIFEWKHTGLPLGLLSLLGGAPRLAAAQWAHMRLYWEWASRNAPCSRHGEPAVPMYLNVPWEDMLAKEYDEVVAYTGITPLPQFLEKRQQH

Output: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSTYTPKAGDTTRSWYVIDATDVVLGRLAVEAAKLLRGKHKPTFTPNVDGGDFVIIINADKISLSGDKLTKKFAYSHSGYPGGLRKRAIGDLLAKHPTRVVENAITGMLPHTKLGRQIQKKLKVYAGPEHPHTAQQPVPFEIKQVAQ

Output: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


Instruction: Predict the functional description of the protein sequence below.

Input: MKQPNKAPRANIAAPKGTATPKRRRKTRDELDAEARDRKRQKKHSGNRSGARTNVEGSNKKGHSQTQEKDPRVGSKVPVPLVIESQVKAKSMPKPVEKNVVKPRLTPEEELAKLENDERLDALLDRLDNDEVLNKEDQAYVDLTLDRIDALMEQLGIELGDDEDDVEREEKQEDILQLLKRGNPKDTF

Output: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.


Instruction: What is the functional description of the protein sequence?

Input: MSGTLLAFDFGTKSIGVAIGQRITGTARPLTAIKAQDGTPDWTLIERLLKEWQPEAVIVGLPLNMDGTEQPLTARARKFANKIHGRFGAVVKLHDERLSTVEARAGLFEHGGFRALNKGSVDSASAVIILESFFEQGF

Output: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVSDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN

Output: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.


Instruction: What is the functional description of the protein sequence?

Output: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.


Instruction: What is the functional description of the protein sequence?

Output: Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSNPITITESAQSHFAKLLAQQPEGTNIRVFVVNPGTQNAECGVSYCPPEAVEATDTEYPFSGFSAYVDGLSLPFLEEAVIDFVTDKMGSQLTLKAPNAKMRKVSDDASLMERVEYALQTQVNPQLAGHGGHVRLISISDDGVALVQFGGGCNGCSMVDVTLKEGIEKELLAQFAGELTAVRDSTEHDRGEHSYY

Output: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.


Instruction: Predict the general functional description of the protein sequence.

Input: MESTSPALSVSIAVLTALLGLTGFGIYTAFGPPSRQLDDPFDDHDD

Output: May play a role in photosystem I and II biogenesis.


Instruction: Predict the functional description of the protein sequence below.

Output: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


Instruction: What is the functional description of the protein sequence?

Output: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


Instruction: What is the functional description of the protein sequence?

Output: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.


Instruction: What is the functional description of the protein sequence?

Input: MPNLQTVAQLISLFLILTSGPAIIVLIALRRGNL

Output: A core subunit of photosystem II (PSII).


Instruction: What is the functional description of the protein sequence?

Input: MSQETEKDLEQTQNEELVEEAQSDEKKDQEVDPVEAAQAEAAEYKDKYIRAHADFENAKKRLEKDKMNAVAYANESFAKDILAVLDSFENALSAIEGANKENAAEVLEKMQEGVKLTYEQLKKVLEKNSIKEIESKGTFNPEVHQAIMQVDSDEHKTDDIVQVMQKGYTIKDRVLRPAMVSTAK

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.


Instruction: What is the functional description of the protein sequence?

Output: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSKEDVIEVEGVIKEALPNATFQVELENGHVVLAHLSGKLRMHFIRILPGDKVTVELSPYDLTRGRITWRKK

Output: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


Instruction: What is the functional description of the protein sequence?

Input: MSRRHRAEKREINPDPKFGDLVVTKFMNAIMLHGKKSVAESIVYGAFDAVQSKLKQEPVTVFHSALDNIAPHVEVRSRRVGGATYQVPVDVRPERRQALAIRWLIAAARKRNETTMVDRLCGELMDAANNRGSAVKKREDTHKMADANRAFSHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: Predict the functional description of the protein sequence below.

Input: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQTVREREAAEIAAVSAIAEGRSL

Output: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.


Instruction: Predict the general functional description of the protein sequence.

Output: Multifunctional regulator of fatty acid metabolism.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMKPQTYMNHSGESVGSALHFWKLGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAHVGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEECLVRATEAARLAIELGAAKAMNQVNRRASAAG

Output: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).


Instruction: Predict the general functional description of the protein sequence.

Output: Involved in phosphonate degradation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Is able to cleave peptidoglycan and affects clumping and separation of bacterial cells.


Instruction: Predict the general functional description of the protein sequence.

Input: MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKHSKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLDK

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: What is the functional description of the protein sequence?

Output: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSMTDNVADMLTRIRNAYKSKLINVSFPSSKIKISILDVLQKEGYIKDYITTQKNNISYTEVALKYSVNGDASICEIHRVSKPGKRVYSPIKDLKGYYNNMGIYILSTPYGVMSDREAHIKNVGGEVICKVF

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MHVKKGDKVVVISGKDKGKQGVILAAFPKNDRVLVEGINLVKKHSKPTQANPQGGISEQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLDK

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARIAGIDIPREKRVEIALTYVYGIGLTRSKLILANTGVNPDTRVKDLSDSDVQKLRGATEEFTLEGDLRRKEGMALKRLQDIGCVRGRRHRMSLPVRGQRTRTNARTRRGSRKTVAGRKK

Output: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the reversible oxidation of malate to oxaloacetate.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MARSRFDTGSGPSQRQLRVGELIRRTLSSVLNQGDIHDPDLNRMSITVGEVRTSPDLKVATAYVLPLGGHGAQDALDALRRNRHELRRAVSKELTLKFSPELRFQIDETFDRMDETRRLLSQDHVRQDLDKPDED

Output: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


Instruction: What is the functional description of the protein sequence?

Input: MLQPIGDRVIVKVKDEEEKTVGGIVLASNAKKKPTEGEVVAVGEGAYASNGEKIPMSVKKGDVVLYDRYSGTNVEYEGEKYLVLHEKDILAIAK

Output: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKCPKCNSTQSKVVDSRHADELNAIRRRRECENCGTRFTTFEHIEVSQLIVVKKDGTREQFSREKILNGLVRSCEKRPVRYQQLEDITNKVEWQLRDEGHTEVSSRDIGEHVMNLLMHVDQVSYVRFASVYKEFKDVDQLLASMQGILSENKRSDA

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPKEDIHPTWYPDAKVICNGEVVMTTGSTQPEIHVDVWSGNHPFFTGTQKILDTEGRVDRFMRKYGMADSENDSTDKKKTTNEKKVSDSPSKES

Output: Binds the 23S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Oxidative deamination of D-amino acids.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).


Instruction: Predict the functional description of the protein sequence below.

Input: MSETKNVRTLQGKVVSDKMDKTVTVLVERKVKHPLYGKIIRLSTKIHAHDENNQYGIGDVVVISESRPLSKTKSWVVSELVEKARSI

Output: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MSRTIFCTYLQRDAEGQDFQLYPGELGKRIYNEISKDAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVSFLFEGKDVHIEGYTPEDKK

Output: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.


Instruction: Predict the general functional description of the protein sequence.

Input: MSNETVLPLQFTEAAAKKVKLLISDEENPNLKLRVYITGGGCSGFQYGFTFDDQVNDGDMTIEKQGVELVVDPMSLQYLVGGAVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI

Output: Required for insertion of 4Fe-4S clusters for at least IspG.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: What is the functional description of the protein sequence?

Output: Molecular chaperone. Has ATPase activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Specifically methylates the guanosine in position 1516 of 16S rRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Endoribonuclease that initiates mRNA decay.


Instruction: Predict the general functional description of the protein sequence.

Input: MSRRRGKVEPRHIEGDPKYNDKVISKFINCLMVDGKKSVAESVFYDALEVIAKKTGQDPFAVFQEALENAKPQVEVKSRRVGGVTYQVPIEVRPERRLALGIRWLIKYSRGRNEKSMKNKLAAEFMEAQKGTGSAIKKKEDIRKMADANKAFSHYRW

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.


Instruction: What is the functional description of the protein sequence?

Input: MALLIEDKKQIVAEVSEVASKAFAAVVADYQGLSVEQLTTLRVEARKLGVTTRIVRNTLAKRAFQGTQFDILNDNLVGPTILGFSTSEDDMGAAARLFEEFAKTNKAFELKAAAFDGKVYQGADVSVIANLPNQEKALTMLASVLQAPISKLGRLITALKEKNESEAA

Output: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSDDDVNEFAKNLLSAKRELTYCSVCGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHGLYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLLKPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL

Output: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: What is the functional description of the protein sequence?

Output: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MQVKSHKPSKQRKYLYNAPIHHRGKIMSAPLSEELKSKYGINSIPIRKGDRVKVMRGDYRGTEGEVISVDRKRYRIAVKGIVRRKADGTEVPVPIHPSKVVITKLYLKDEARKRLLERKGVKVEEIVEESE

Output: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.;


Instruction: What is the functional description of the protein sequence?

Input: MAAPKSTATRARRGRRVVKKNVTQGHAYIKSTFNNTIVSITDPKGHVISWASSGQVGFKGSRKSTPFAAQLAAESAARKAMEHGMKKVDVFVKGPGSGRETAIRSLSTAGLEVGTIADVTPQPHNGCRPPKRRRV

Output: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.


Instruction: What is the functional description of the protein sequence?

Output: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MKNADRGVAAELDGSDLRVAIVQARFNAAITEQLASSCIAELEALGVLAKHIKHVTVPGALEVALALQALAEQKDHDALIALGCIIRGETYHFELVANESGAAVTRVSLEHGVPIANAILTVENEAQAWARADEKGRDAARVAVEMANLMEDLS

Output: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


Instruction: What is the functional description of the protein sequence?

Output: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MAEAKALPRFKKLYQDNIRKALLEEFKYDNEMQIPRITKVVLNMGVGEATGDSKKPAVAAEDLAMIAGQKAVVTRARNSIATFKLREGMPIGAKVTLRQDRMYEFLDRLITIALPRVRDFRGLNPKSFDGRGNYAMGIKEHIVFPEINYDKVDQIWGMDIIVCTTAKTDDEARSLLRAFNFPFRQ

Output: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MALTLTDVKRIAHLARLELADADAEHTLVQLNDFFGLVEQMQAVDTSGIAPLAHPIEQIEDVALRLRNDVVTETVEREAFQRPAPAVQDGLYLVPKVIE

Output: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).


Instruction: What is the functional description of the protein sequence?

Output: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Required for maturation of 30S ribosomal subunits.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: GTPase that plays an essential role in the late steps of ribosome biogenesis.


Instruction: What is the functional description of the protein sequence?

Input: MQLVIVAVGHKMPGWIETGFSEYAKRMPPELRIELREVKPETRSSSNNAATVMQREAARIEAVLGSLSKQCRIVALDERGRDFTTVQLAAQLTDWQREGGDVAFLIGGADGLDPALKARASTLIRLSSLTLPHGMVRVLLAEQLYRAWSVTQNHPYHRA

Output: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.


Instruction: What is the functional description of the protein sequence?

Output: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


Instruction: What is the functional description of the protein sequence?

Input: MFYWILLALAIATEITGTLSMKWASVGNGNAGFILMLVMITLSYIFLSFAVKKIALGVAYALWEGIGILFITIFSVLLFDEALSTMKIAGLLTLVAGIVLIKSGTRKPGKPVKGAARATI

Output: Catalyzes the excretion of spermidine.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Controls the transcription of genes involved in arginine and lysine metabolism.


Instruction: Predict the general functional description of the protein sequence.

Output: Required for anaerobic carnitine reduction. May bring reductant to CaiA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.


Instruction: Predict the general functional description of the protein sequence.

Input: MKSSLKPVEKYAYSIFEIAKEEKKLDLYKHNLETINSIIEEVPAFFEAVGDPARDRNERKQIVIKNLEGEIDIYLISLIDLLIDVKSIKLLKKIVLKALDFVNEALSVKKVLITTAYELTKNQIDRLVQSLKKKYACEKIEPIVVVDKSIIGGLSINFESQVLDNSLKTKLFNVVKKTN

Output: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MASTNFRPLHDRVVVRRVESEAKTKGGIIIPDTAKEKPQEGEIVAVGSGARDESGKVVALDVKAGDRILFGKWSGTEVKIDGEDLLIMKEADIMGIIG

Output: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.


Instruction: Predict the general functional description of the protein sequence.

Output: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.


Instruction: Predict the functional description of the protein sequence below.

Output: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.


Instruction: What is the functional description of the protein sequence?

Input: MYAIIETGGKQIKVEAGQEIYIEKLDVEAGETVTFDKVLFVGGENVKVGSPVVEGATVTAKVEKHGRAKKIIVFKYKAKKNNRKKQGHRQPYTKLVVEAINA

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: Predict the general functional description of the protein sequence.

Input: MAKEKIRIRLKAYDHRILDQSAEKIVETAKRSGATVSGPIPLPTEKTVYTILRAVHKYKDSREQFEMRTHKRLIDIVSPTPQTVDSLMRLDLPSGVDIEIKL

Output: Involved in the binding of tRNA to the ribosomes.


Instruction: What is the functional description of the protein sequence?

Output: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.


Instruction: Predict the functional description of the protein sequence below.

Input: MRCPSCSHNGTRVLDSRPVDEGRSIRRRRECESCLSRFTTFERVEESPLIVVKKEGTREEFNKEKILRGLIKACEKRPVSLRQLEEVTQSVERELRNLGISEVKSDMIGEIVMEELRDIDDVAYVRFASVYRQFKDLNVFIEELKDILQKERE

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Predict the functional description of the protein sequence below.

Input: MISDKIKLTAKDILEKEFKTGMRGYQQEEVDKFLDMIIKDYEAFHKEFEQLKQQNARLKRELEEQKLAATQVPQQPVVQTPVAQPVYNNTNTDILKRLSNLEKAVFGSKLYE

Output: Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.


Instruction: Predict the functional description of the protein sequence below.

Input: MKVIASTLRKGNVVDKDGKLYVILTAENIHPGKGTPVTQLDMRRITDGVKISERYRTTEQVERAFVEDRDHTFLYQDGEGYHFMNPESYEQIAVPADVVGDAAPYLQEGMTVTLSTHNGVPLTIELPQRMTFEIVETEPVTKGQTASSSYKPALLSNGVKTSVPPHVSTGTRVVIMTADGSYVERAKD

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL

Output: Acts as a radical domain for damaged PFL and possibly other radical proteins.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Controls the transcription of genes involved in arginine and lysine metabolism.


Instruction: Predict the general functional description of the protein sequence.

Input: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK

Output: Involved in pyrimidine catabolism. Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously. RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


Instruction: Predict the general functional description of the protein sequence.

Input: MLFLTQVREVVVSEVNIPLSFSDAAATRVQTLIAEEENPDLKLRVYITGGGCSGFQYGFTFDEKVNDGDTTIVNSGVTLVVDPMSLQYLMGGMVDYTEGLEGARFFVNNPNATTTCGCGASFSV

Output: Required for insertion of 4Fe-4S clusters for at least IspG.


Instruction: What is the functional description of the protein sequence?

Input: MKQILNILPMFIFFIFYKFYDIFIASGSLIVISGLICIIHWIFYNEIDKISLFSFLSVFFFGSLTIFFHNSQFIKWKITIIYIIFSLVLLISQFFTRKPMIQRFLEKDIKISNIYWRKINFIWSLFFLFCAILNIYIAYYFSETIWVNFKVFGFTSLTFFLILITSIYINCKISKNK

Output: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MANVVDQSKEQMKKSVESTKENFAGIRTGRANPALLNGIVVEYYGAPTPLKHVATIGVPEPRTLSVTPFDPSQANAVEKALRDSDLGASPRRNGSAILLTMPELTEDRRKEYVKLAKSKAEDGKVAVRNIRRKSKEAIDKAVKDGEMGEDEGDRLLKELDKVTKATTDELDALLEAKQKEIMEV

Output: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.


Instruction: Predict the functional description of the protein sequence below.

Output: Catalyzes the reversible oxidation of malate to oxaloacetate.


Instruction: Predict the general functional description of the protein sequence.

Input: MTSYTFSRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNTEQHPRMGLTVAKRFVKRANQRNRIKRVIRDSFRLNQHDIPHLDIVVLVRNGVMEMENAEINKLIEKLWRKLSRRYNG

Output: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


Instruction: Predict the general functional description of the protein sequence.

Output: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


Instruction: Predict the functional description of the protein sequence below.

Output: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MASYGMGDLKKGLKIEIDGIPFKIVEYQHVKPGKGPAFVRIKIKSFIDGKVLEKTFHAGDKCESPNLEEKQMQYLYDDGENCQFMDTQTYEQVAISDEDVGEAKKWMLDGTMVDVLFHNGKAIGVEVPQVMELKIIETAPNFKGDTQGSNKKPATLETGAVVQIPFHVLEGEIIRVDTVRGEYIERANK

Output: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.


Instruction: What is the functional description of the protein sequence?

Input: MEIVAENRKARFDYFVLQEYDAGMVLVGSEVKSLRQRKVNMGDAYVLEKDMELWIHNLHISEYNRSDRKNHKPLRVRKLLLRKREIHKIAGNIKVSGLAVVPLMIFFNNKGIAKIKIAIVKGKKLYDKREAIKTRDWQREKSRISRREV

Output: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


Instruction: What is the functional description of the protein sequence?

Input: MKIIAKKDLFINDEIRVREVRLVGLEGEQLGIKPLSEAQSLADAANVDLVLIQPQAVPPVAKLMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLADFAEATQDIAIIEQRAKMDGRQMFMQLAPISDKK

Output: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.


Instruction: Predict the functional description of the protein sequence below.

Input: MANIKSQQKRNRTNERARLRNKAVKSSLRTAVRAFREAAHAGDKAKAAELLASTNRKLDKAASKGVIHKNQAANKKSALAQALNKL

Output: Binds directly to 16S ribosomal RNA.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.


Instruction: Predict the functional description of the protein sequence below.

Input: MTFNPNIATHTLEAEGLRCPEPVMMVRKTIRTMLDGEVLLVTADDPSTTRDIPSFCRFMDHQLLGAQIDQLPYQYLIKKGLA

Output: Sulfur carrier protein which probably makes part of a sulfur-relay system.


Instruction: Predict the general functional description of the protein sequence.

Input: MAERSQNLQDLFLNTVRKQKISLTIFLINGVKLTGVVTSFDNFCVLLRRDGHSQLVYKHAISTIMPGQPLQMFENEEAAS

Output: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.


Instruction: Predict the general functional description of the protein sequence.

Output: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.


Instruction: What is the functional description of the protein sequence?

Input: MSKVKKNDETLSEVLVDVNRVTKVVKGGRSFAFSAYVVVGDKAGRVGAGHGKAKEVNEARGKAKQAAKKRMMKVPLYQNRTIHHDVVGKSGAAKVILRRAKAGTGIIAGGSMRAIFDSLGVHDIVAKSIGSTNVYAMISATFDALNKLASPKSIAMRRDKKVNEISVKSADIQVNE

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: What is the functional description of the protein sequence?

Output: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.


Instruction: Predict the general functional description of the protein sequence.

Output: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


Instruction: Predict the functional description of the protein sequence below.

Input: MAFKKKFTPKKKFCRFCANKNLPVDYKRPDILKDFITDRGKIIARRITGTCAKCQRRLTLEIKRARQMALLYYTATHSAEHLKKM

Output: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.


Instruction: Predict the general functional description of the protein sequence.

Output: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.


Instruction: Predict the functional description of the protein sequence below.

Output: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MGDKTKVQVSKLKPGRYIIIDGEPCRIVNITVSSPGKHGSAKARIEAVGIFDGKVRSIVKPTSAEVDVPIIDKRVGQVIAITPDTVQIMDMETYELYDVPIETGVEDEVKDQLKEGITVEYWETLGRIQIKKVRGE

Output: Functions by promoting the formation of the first peptide bond.


Instruction: What is the functional description of the protein sequence?

Input: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGEAVEFDQVLMVANGEEIKIGVPFVDGGKIKAEVVAHGRGEKVKIVKFRRRKHYRKQAGHRQWFTDVKITGISA

Output: This protein binds to 23S rRNA in the presence of protein L20.


Instruction: What is the functional description of the protein sequence?

Input: MKTMFILALIALAATSVVAQLDTTCSQGYGQCQQQPQQQVNTCSALLQQCSPTPYVQSQMWQASGCQLMRQQCCQPLAQISEQARCQAVCSVAQVIMRQQQGQSFGQPQQQVQSFSQPQHQVPIEITRMVLQTLPSMCNVNIPQYCTTTPCRTITQTPYNIPMSATCVGGTC

Output: Seed storage protein. Not integrated in the gluten polymer through disulfide bonds, unless incorporated by reduction and reoxidation during dough making. Increases dough strength and bread volume, but decreases dough stability when added into a base wheat flour (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MKVTLIAILTCAAVLVLHTTAAEELEESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVKV

Output: Postsynaptic neurotoxin.


Instruction: Predict the general functional description of the protein sequence.

Input: MEKLTILLLVAAVLMSTQAMFQGGGEKRPKDKIKFLSKRKTNAESWWEGECLGWSNGCTQPSDCCSNNCKGRNCDIW

Output: Inhibits voltage-gated ion channels.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Oxidoreductase; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia . The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity). The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity). The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity). The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity). Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity). The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units . Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 . CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization . The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis . It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity). Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 . Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin .


Instruction: Predict the functional description of the protein sequence below.

Output: May be involved in the folding of the extracellular lipase during its passage through the periplasm.


Instruction: Predict the functional description of the protein sequence below.

Input: MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQIPGKEEEASVTILDSSEEDKEKEEVAAVKIQAAFRGHVAREEVKKMKTDSLQNEEKEENK

Output: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MFKRKSTAELAAQMAKLNGNKGFSSEDKGEWKLKLDNAGNGQAVIRFL

Output: Binds preferentially to single-stranded DNA and therefore, destabilizes double-stranded DNA. It is involved in DNA replication, repair and recombination. Binds ss-DNA as the replication fork advances and stimulates the replisome processivity and accuracy.


Instruction: Predict the general functional description of the protein sequence.

Input: MNKSLKEIYYQDVIPGLIEQFNYTNIHQVLKITKITLNRGLGEASKNNKILEASIKEFELISGQHPLINKARKSVAGFKIREGMPVGISVTLRKKLMYTFLEKLIHLSLPRIRDFRGVSVKSFDGRGNYNLGIKEQLIFPEIEYDQVDQVRGLDISITTTAKTQQEGIALLRALGMPFNDN

Output: Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MEQMRQDIIELKQNDKSQEQRISLLERTSDRHDQQIQAVTESLSKIHENTTWIKRTITGAIISTLSTVVVGGILTIVWNLVKN

Output: Probably functions as a holin together with holin-like protein 26. Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).


Instruction: What is the functional description of the protein sequence?

Output: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MAVCIIDHDNIRGVIYFEPVHGKDKVIGLKSGTYSLIIHRYGDISQGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNISTIIGKALSISKNDQRLACGVIGISYINEKIIHFLTINENGV

Output: Virion protein with no enzymatic activity.


Instruction: Predict the general functional description of the protein sequence.

Input: MNSLFMIFSLGIVGASLMVISTPNPVYSVFWLVIAFVNAAVMFISLGLDYIGLIFIIVYVGAIAILFLFVIMLIQQPNKIDSQDHSHFLPIGLSVIFLFYSLLTNSPKYISNPVIGSRTNIGAIGSHLYTTYYELVLIASLVLLVAMIGAILLAKQPNSPFLYNSHGESLRSRQDLFLQISREHL

Output: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Probably forms part of a binding-protein-dependent phosphite transporter. Probably responsible for the translocation of the substrate across the membrane.


Instruction: Predict the functional description of the protein sequence below.

Input: MARSVVVALLVLLSLSGLEAIQHAPKIQVYSRHPAENGKPNFLNCYVSGFHPSDIEVDLLKNGKKIEKVEHSDLSFSKDWSFYLLYYTEFTPNEKDEYACRVSHVTFSTPKTVKWDRTM

Output: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).


Instruction: What is the functional description of the protein sequence?

Input: EGDVAKGEAAFKRCSACHAIGEGAKNKVGPQLNGIIGRTAGGDPDYNYSNAMKKAGGEGLVWTPQELRDFLSAPKKKIPGNKMALAGISKPEELDNLIAYLIFSASSKPAZ

Output: Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: AYKIVTSQCTVCGACEFECPNAAISMKRGTYVIDATKCTECEGQFDKPQCVSVCPVDNTCVPA

Output: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MRITEANPDPDAKAVPAAAAPSTASDAAAAAAATAATAAAAAAATAATAAAAAAATAATAAKAAALTAANAAAAAAATAAAAARG

Output: Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Input: MSKSNESAVAFQTAIASIKLIQASSVLDLTEDDFDFLTRDRVWIATDRSRARRAIEACVYGTLDFVGYPRFPAPVEFISAVIAYYVHPVNIQTACLIMEGAEFTENIVNGVERPVKASELFAFTLLVRAGNKDLIGHAETNIREQLRAQGVM

Output: Assembles the procapsid by joining twelve 12S pre-assembly complex into a T=1 icosahedral particle, called 108S procapsid. Ten proteins D bind each 12S complex, which are formed by three pentamers of F, G, B protein and a H protein. The scaffolding protein is released from the provirion after genome packaging to form the mature virion.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTLSRNSHKEDQLEEKVLVVNRCCKVVKGGRKFSFSALILVGDRKGRLGFGFAKANELTDAIRKGGDAARKNLVSINSLEGGSIPHEVLVNHDGAELLLKPAKPGTGIVAGSRIRLILEMAGVKDIVAKSLGSNNPMNQVKAAFKALLTLSCKDDIMKRRAVIND

Output: With S4 and S12 plays an important role in translational accuracy.;


Instruction: Predict the functional description of the protein sequence below.

Input: MSRTIFCTFLQREAEGQDFQLYPGELGKRIYNEISKEAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVNFLFEGKEVHIEGYTPEDKK

Output: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.


Instruction: Predict the general functional description of the protein sequence.

Input: QGGWPRPGPEIPP

Output: This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: MARQMMTVGCLILIVVLLDMMVPVFNTCPGQYDECGNGPEEGECCGTHNYCCKNACTTYHHCHGGRDAGKLLRSLKKLKLTTH

Output: Acts as a neurotoxin by inhibiting voltage-gated potassium channels (Kv).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Putative nuclease that seems to be required for double-strand break repair, homologous recombination, and production of full-length viral genomic DNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MTNLLNKSLEENGSFLTAVYIFVGFVALYLLGRALQAFVQAADACCLFWYTWVVVPGAKGTAFVYNHTYGKKLNKPELEAVVVNEFPKNGWNNKNPANFQDVQRNKLYS

Output: Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.


Instruction: What is the functional description of the protein sequence?

Output: Involved in the resistance (detoxification) of the fungal toxin fusaric acid.


Instruction: What is the functional description of the protein sequence?

Input: IYVRPTKDELLYCGEFRELGQPDKKCRCDGKPCTVGRCKFARGDADDKCTSA

Output: Potent inhibitor of fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. May prevent blood from clotting during either feeding and/or storage of ingested blood.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MPLTPPPDYTRVYTALAIGASIAFFTGLITRNTLPSVGDLQHNLPHGGRYRDGTKSVEYCGPRKLNSVESGSRWTFQPWLLVIVLVALIIALGRQGHNCRACGRSH

Output: Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata,.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the phage ejection machinery. Pilot protein for the formation of the tube that conducts the genome into the target cell. Probably involved in penetration of the bacterial outer membrane and for making the peptidoglycan layer accessible to the viral transglycosylase. Essential for viral infectivity.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Suppressor of viral-induced RNA silencing.


Instruction: What is the functional description of the protein sequence?

Input: MTEQKRPVLTLKRKTEGETPTRSRKTIINVTTPPKWKVKKQKLAEKAAREAELTAKKAQARQALSIYLNLPTLDEAVNTLKPWWPGLFDGDTPRLLACGIRDVLLEDVAQRNIPLSHKKLRRALKAITRSESYLCAMKAGACRYDTEGYVTEHISQEEEVYAAERLDKIRRQNRIKAELQAVLDEQ

Output: One of the components on the FinOP fertility inhibition complex, which inhibits the expression of traJ gene, which in turn regulates the expression of some 20 transfer genes. The transfer genes are responsible for the process, called conjugal transfer, in which DNA is transmitted from one bacterial host to another. RNA-binding that interacts with the traJ mRNA and its antisense RNA, finP, stabilizing finP against endonucleolytic degradation and facilitating sense-antisense RNA recognition (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Input: AVDDYAATRYPIILVHGLTTDSKYGGVVEYXYRNPNDLTSHXXAAYVYELRSDPLD

Output: This thermostable and solvent-tolerant lipase is rather nonspecific. It can synthesize both primary and secondary alcohol esters. Simple triglycerides of short and middle chain fatty acids (C<13) are the preferred substrates.


Instruction: What is the functional description of the protein sequence?

Input: MSQNILLLIRADIKAVDEKVDALQQAVNDVSANLPDTSELSAKLDAQATTLDTIVTQVNNINDVLNPDLPDVPGNLQKQQQQKKSNKK

Output: Seems to be involved in the morphogenesis of the polyhedra. Forms extensive fibrillar structures in both nucleus and cytoplasm. It is involved in the liberation of polyhedra from infected-insect cell.


Instruction: Predict the general functional description of the protein sequence.

Output: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.


Instruction: Predict the functional description of the protein sequence below.

Output: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: DICDIAIAQCSLTLCQDCENTPICELAVKGSCPPPWS

Output: Mating ciliate pheromones (or gamones) are diffusible extracellular communication signals that distinguish different intraspecific classes of cells commonly referred to as 'mating types'. They prepare the latter for conjugation by changing their cell surface properties.


Instruction: Predict the functional description of the protein sequence below.

Input: MSDFNLVGVIRVMPTDPDVNLDELEEKLKKVIPEKYGLAKVEREPIAFGLVALKFYVLGRDEEGYSFDEVAEKFEEVENVESAEVETVSRI

Output: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAIKIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI

Output: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.


Instruction: What is the functional description of the protein sequence?

Output: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MHCPFCRHPDSRVIDSRETDEGQAIRRRRSCPECGRRFTTVETAVLAVVKRSGVTEPFSREKVISGVRRACQGRQVDDDALNLLAQQVEDSVRAAGSPEIPSHDVGLAILGPLRELDEVAYLRFASVYRSFSSADDFAREIEALRAHRNLSAHS

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation. Together with inhibition of host splicing by ICP27, contributes to an overall decrease in host protein synthesis. Also, after the onset of viral transcription, accelerates the turnover of viral mRNA, thereby facilitating the sequential expression of different classes of viral genes. Binds translation initiation factors eIF4H, eIF4AI, and eIF4AII, thereby may interact directly with the translation initiation complex and thus digest specifically mRNAs. Also impedes antigen presentation by major histocompatibility complex class I and class II molecules, inhibits secretion of cytokines that would otherwise recruit lymphocytes and neutrophils cells to the site of infection and blocks the activation of dendritic cells. Impedes the alpha/beta interferon-mediated response to infection (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Input: FMRF

Output: Myoactive; cardioexcitatory substance. Pharmacological activities include augmentation, induction, and regularization of cardiac contraction.


Instruction: Predict the general functional description of the protein sequence.

Output: Confers resistance to norfloxacin and enoxacin.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: RFKKIRRLGALPGFTSKRPRSGSDLKNQLRSGKKSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQILLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNDRIVDIPSYRCKPRDIITTKNKQRSKALIQNYIASSPHHEELPNHLTIDPFQYKGLVNQIIDNKWIGLKIN

Output: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.;


Instruction: Can you provide the functional description of the following protein sequence?

Input: GVPSVSTVNVAQKQHDVNFLLFKVYI

Output: Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.


Instruction: Predict the functional description of the protein sequence below.

Input: GLLQTITEKLKEFAGGLVTGVQS

Output: Has no antimicrobial or anticancer activity.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: APPGFTPFRSKAV

Output: Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).


Instruction: What is the functional description of the protein sequence?

Output: Essential cell division protein.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEIQEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Output: Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB21 (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).


Instruction: Predict the general functional description of the protein sequence.

Input: MPDLKSLIREVPDFPKPGILFYDITTLLKDPSGFHGVIDGLKDHYRDIKVDTVLGIEARGFIFAPALAYALGAGFVPVRKPKKLPAECVRITYDLEYGTDTLEMHKDAIGNGHRVLIVDDLLATGGTASAAARMVQDAGGIVVGLGFVIELTFLAGRQRLNGHDVFSLLQYDK

Output: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


Instruction: What is the functional description of the protein sequence?

Input: MAKITRKRRVKKNIESGIVHIQSTFNNTIVMITDVHGNALAWSSAGALGFKGSKKSTPFAAQMASEAAAKAAQEQGLKTVSVTVKGPGSGRESAIRALAAAGLNVTSISDVTPVPHNGARPPKRRRV

Output: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.


Instruction: Predict the functional description of the protein sequence below.

Output: Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.


Instruction: Can you provide the functional description of the following protein sequence?

Input: MCSPSETKTSVIDQLKRAASAEEFFTTLGVDYDPQVVNVARLHILKRMGQYLASEDLAGLSNCAVTERCKAVLERAYADFVASSPLDQRVFKVLKDAVSPKRGAFVPLDALK

Output: May protect the nitrogenase Fe-Mo protein from oxidative damage.


Instruction: Predict the general functional description of the protein sequence.

Input: MRCPSCSSLDTQVKDSRPTEDSSVIRRRRVCLACNFRFTTFERVQLRELTVIKRNGRRVPFDRDKLVRSLQISLRKRPVDPERLEEMVSAVVRELESGGESEISSEAIGEIVMEHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSSDELARAALLRK

Output: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.


Instruction: What is the functional description of the protein sequence?

Input: MSYTINAVTRTEIGKGSSRRLRHAGKVPAVIYGPGKEPVSIKFEHKDIINIQLNDDFYTTDLTVSIEGKEVKVRVKAIQRHAFKQLVEHIDFMFA

Output: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.