file_name stringlengths 45 104 | question_id stringlengths 9 23 | fraud_type stringclasses 3
values | fraud_sub_types listlengths 1 3 | ground_truth listlengths 1 3 | mask_indices listlengths 1 9 | mask_caption stringclasses 65
values | mask_path stringlengths 0 106 | figure_caption stringclasses 151
values | figure_related_sentences stringclasses 151
values | inconsistent_part stringclasses 3
values | tampered_sentences listlengths 1 3 | golden_sentences listlengths 1 3 | metadata dict |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
forgery/authentic/2010073147/panel/2010073147_3_1/2010073147_3_1_3.png | forgery_1522 | forgery | [
"None"
] | [
"D"
] | [
0
] | [
""
] | [
""
] | {
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"2010073147"
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"figure_ids": [
"None"
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"scenario": "Stained Micrograph"
} | |||||
forgery/authentic/61727468/panel/61727468_4_2.png | forgery_1523 | forgery | [
"None"
] | [
"D"
] | [
0
] | [
""
] | [
""
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"None"
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"scenario": "Physical Object"
} | |||||
text_image_inconsistency/numerical/2010027936_TII_01/figure/2010027936_TII_01_8.png | consistency_1 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | EDS analysis at the grain boundaries of Fe-6.5 wt % Si steel strip samples: (a) 1.0 wt % Cu, (b) 1.5 wt % Cu, and (c) 2.0 wt % Cu. | Further SEM microstructural examination revealed that Cu rich precipitates were absent in the 1.5 wt % Cu specimen (Figure 8a), but became visible in the 1.5 wt % Cu specimen (Figure 8b). The precipitates in the 1.5 wt % Cu specimen were tiny, few, and irregularly scattered at grain boundaries. Cu-rich precipitates wer... | related_sentences | [
"Further SEM microstructural examination revealed that Cu rich precipitates were absent in the 1.5 wt % Cu specimen (Figure 8a),",
"Cu-rich precipitates were continuous or semicontinuous at grain boundaries as the Cu dosage was raised to 1.0 wt %,"
] | [
"Further SEM microstructural examination revealed that Cu rich precipitates were absent in the 1.0 wt % Cu specimen (Figure 8a),",
"Cu-rich precipitates were continuous or semicontinuous at grain boundaries as the Cu dosage was raised to 2.0 wt %,"
] | {
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} | ||
text_image_inconsistency/numerical/2010000860_TII_01/figure/2010000860_TII_01_1.png | consistency_2 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2. BcR stimulation downregulates cathepsin S activity in IIA1.6 cells. (A)Accumulation of the p10 invariant chain fragment in BcR-stimulated IIA1.6 cells. IIA1.6 cells were incubated for the times indicated with anti–mouse IgG antibodies, as described in Materials and Methods. The p10 fragment was detected with ... | BcR stimulation, showed an increase in the amount of p10 invariant chain fragment detected with a rabbit antiserum specific for the cytosolic domain of the invariant chain,whereas MHC class II and tubulin levels remained constant (Fig. 2 A). The effect of BcR stimulation on invariant chain degradation depended on the ... | related_sentences | [
"the p10 fragment was first detected after 60 min, increased to reach a maximum at 3 h and then returned to its initial level after 6 h of BcR stimulation (Fig. 2 A)."
] | [
"the p10 fragment was first detected after 30 min, increased to reach a maximum at 3 h and then returned to its initial level after 6 h of BcR stimulation (Fig. 2 A)."
] | {
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"2010000104"
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"None"
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"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010064544_TII_01/figure/2010064544_TII_01_4.png | consistency_3 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 5. Summary of genome-wide STAT5 binding sites at L1. (A) The Venn diagram shows the number of identified STAT5A and STAT5B sites (peaks) in AABB tissue and STAT5B sites in BB tissue. (B) Average peak heights of STAT5A and STAT5B in AABB and BB tissues were estimated after library size normalization (RPM, reads p... | Totals of 26,231 STAT5A and 6,969 STAT5B peaks in wild type (AABB) and 2,574 STAT5B peaks in Stat5a-null (BB) were identified as STAT5 binding sites (Figure 5). For visualization, total number of reads in each sample was normalized to 10 million. The ChIP-seq data are deposited in GEO under accession number GSE40930. I... | related_sentences | [
"In general, the average STAT5A peak height was 3-fold higher than that of STAT5B (Figure 5B)"
] | [
"In general, the average STAT5A peak height was 5-fold higher than that of STAT5B (Figure 5B)"
] | {
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"2010000117"
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"None"
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"scenario": "Others"
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text_image_inconsistency/numerical/2010065447_TII_01/figure/2010065447_TII_01_3.png | consistency_4 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 4. Editing and ADAR2-binding reduces splicing efficiency at the Gria2 R/G site. (A) RT-PCR shows a gradual reduction of splicing in the presence of a strong (+/+), intermediate (+/−) or weak (−/−) polypyrimidine tract in wildtype (wt) or pre-edited (pre-ed) versions of a Gria2 exon 13 minigene. Pre-mRNA and mRNA... | One of the Gria2 minigenes (+/−; Supplementary Figure S2). An even stronger accumulation of pre-mRNA was observed for the pre-edited -2-3 constructs in context with the strongest and weakest branch points (Figure 4A and B). This demonstrates that guanosines and therefore most likely also inosines introduced by editing ... | caption | [
"The quantification was done from four independent biological replicates",
"Quantification was done from four independent biological replicates"
] | [
"The quantification was done from three independent biological replicates",
"Quantification was done from three independent biological replicates"
] | {
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"2010000124"
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010065498_TII_01/figure/2010065498_TII_01_0.png | consistency_5 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Cdc48 and ubiquitin ligases affect the distribution pattern of ribosome-associated ubiquitinated species. Sucrose gradient sedimentation analysis of ribosomes extracted from the wild-type RS1158 strain (A) and its derivative strain harboring a tetracycline-repressible PTET-O7-CDC48 allele (B). Cells were grow... | RESULTS Gradient analysis of ubiquitinated polypeptides associated with ribosomes in Cdc48-depleted cells To examine how endogenous targets of cotranslational protein QC are distributed among different subpopulations of ribosomes in yeast cells, we fractionated cytoplasmic lysates by sedimentation through sucrose gradi... | related_sentences | [
"The ubiquitin signal in Cdc48-depleted cells was mainly concentrated in fractions 4-7 (Figure 1B)"
] | [
"The ubiquitin signal in Cdc48-depleted cells was mainly concentrated in fractions 3–5 (Figure 1B)"
] | {
"all_images_paths": [
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"paper_ids": [
"2010000139"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010065537_TII_02/figure/2010065537_TII_02_4.png | consistency_6 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 5. Increased U12-dependent intron retention in SMA mice. (A) qPCR validation of U12-dependent intron retention at PND1 and PND5 in spinal cord. (B) qPCR validation of U12-dependent intron retention at PND1 and PND5 in brain. (C) qPCR validation of U12-dependent intron retention at PND1 and PND5 in liver. (D) qPC... | We validated the decrease in retention of the U12-dependent intron and the decrease of the levels of spliced Rasgrp3 by specific qPCR assays in all tissues, at both PND1 and PND5 (Figure 5 and 6). Since retention of the intron could lead to degradation of the transcript via the NMD pathway due to a premature terminatio... | related_sentences | [
"We validated the decrease in retention of the U12-dependent intron and the decrease of the levels of spliced Rasgrp3 by specific qPCR assays in all tissues,",
"together with upregulation of Myh9 transcripts in general.",
"and perhaps explain why we detected fewer U12-dependent intron retention events in periph... | [
"We validated the increase in retention of the U12-dependent intron and the decrease of the levels of spliced Rasgrp3 by specific qPCR assays in all tissues,",
"together with downregulation of Myh9 transcripts in general.",
"and perhaps explain why we detected more U12-dependent intron retention events in perip... | {
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"paper_ids": [
"2010000141"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010065559_TII_02/figure/2010065559_TII_02_0.png | consistency_7 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. BRD4 is required for osteoblast differentiation. (A and B) Alkaline Phosphatase staining of hFOBs differentiated into the osteoblast lineage following DMSO or JQ1 (250nM) (upper panel) and siCNTR or siBRD4 (SmartPool) (lower panel) treatments (A). The stained areas were quantified and displayed as percentage ... | RESULTS BRD4 promotes osteoblast differentiation. To examine the function of BRD4 during lineage specification and maintenance, we examined the effects of BETi on the differentiation of hFOBs (32). Perturbation of BRD4 function by BETi (JQ1) treatment or siRNA-mediated knockdown (Supplementary Figure S1A and B) resulte... | related_sentences | [
"we observed less downregulated genes compared to upregulated genes following JQ1 treatment (Figure 1G)"
] | [
"we observed more downregulated genes compared to upregulated genes following JQ1 treatment (Figure 1G)"
] | {
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"paper_ids": [
"2010000145"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010104206_TII_02/figure/2010104206_TII_02_1.png | consistency_8 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Increased blood glucose in Kir6.1-GOF mice. (A–C, left) Representative intrinsic GFP fluorescence in freshly isolated islets from transgenic mice. High fluorescence in transgenic islets indicates the presence of the Kir6.1 transgene (Kir6.1[x], Control), and loss of fluorescence in transgenic β cells within i... | To study the effects of Kir6.1 subunits of the KATP channel in vivo, we have generated novel mice that express either the Kir6.1 WT (Kir6.1[WT]) or a Kir6.1-GOF, single mutant G343D (Kir6.1[GD]) or double mutant G343D/Q53R (Kir6.1[GD,QR]) transgenes under Cre-recombinase control (Li et al., 2013). Global Cx1 Kir6.1[WT]... | related_sentences | [
" Fig. 2 shows marked gain of fluorescence in pancreatic islets from double transgenic Rip-Kir6.1[WT] (A)",
"1[GD] mice showed diabetes with dramatically low fasting blood glucose levels and a marked impairment of glucose tolerance (Fig."
] | [
" Fig. 2 shows marked loss of fluorescence in pancreatic islets from double transgenic Rip-Kir6.1[WT] (A)",
"1[GD] mice showed diabetes with dramatically high fasting blood glucose levels and a marked impairment of glucose tolerance (Fig."
] | {
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"paper_ids": [
"2010000148"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010105100_TII_01/figure/2010105100_TII_01_1.png | consistency_9 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2Id-immunized mice are protected against MM cells that produce complete myeloma protein while they succumb to FLC MM cells. (A–H) BALB/c mice were immunized i.m./EP with 50µg CCL3-scFv315 or NaCl and challenged 14 days later with MOPC315.BM.Luc.IgAλ2 cells (2×105) that produce complete M315, (left panel), (A–D) ... | The phenomenon was confirmed in experiments using luciferase-labeled MOPC315.BM.Luc cells injected intravenously and bioluminescence as a read-out for tumor load (online supplemental figure 2). Thus, while radiance and M315 levels correlated strongly in the CCL3-scFvA20-immunized mice, there was no such correlation in ... | related_sentences | [
"three mice had a bioluminescence signal and M315 in their sera"
] | [
"two mice had a bioluminescence signal and M315 in their sera"
] | {
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"tampered": true,
"paper_ids": [
"2010000149"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010010059_TII_01/figure/2010010059_TII_01_10.png | consistency_10 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Three chosen parameters measured for one additional cells: (a, d) Dry mass (R² = 0.9344 for the upper graph and R² = 0.8961 for the lower graph); (b, e) Phase skewness (R² = 0.87 for the upper graph and R² = 0.8471 for the lower graph); (c) Phase variance (R² = 0.9801 for the upper graph and R² = 0.954 for the lower gr... | Figure 11 presents the measured values for two additional HeLa cells. The dry mass values seen in Figures 11(a, d) for both of the cells show similar behavior and values to each other and to the previously described cells during all of the cell phases, although different cells have different lifecycle periods. The life... | caption | [
"Three chosen parameters measured for one additional cells: (a,"
] | [
"Three chosen parameters measured for two additional cells: (a,"
] | {
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"paper_ids": [
"2010000163"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010010376_TII_01/figure/2010010376_TII_01_5.png | consistency_11 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | qPCR validation of PUNCH-P results. (A, top panel) Polysome profiles of HeLa cells synchronized to S and M phase by double-thymidine block. (Bottom panel) Total RNA extracted from each of the polysomal fractions visualized by ethidium bromide staining. (B, C) Polysomal association of nonfluctuating mRNAs encoding for C... | To validate some of these results and provide further evidence for the potential of PUNCH-P to measure differences in translation of specific mRNAs, we analyzed the polysome association of selected mRNAs in S and M phase. We chose two proteins whose PUNCH-P expression remained stable throughout the cell cycle and six p... | related_sentences | [
"we extracted total RNA from each of nine polysomal fractions ranging from light to heavy polysomes (Figure 6A, bottom panel) and measured the abundance of specific mRNAs in each fraction using SYBR Fast quantitative PCR (qPCR)"
] | [
"we extracted total RNA from each of seven polysomal fractions ranging from light to heavy polysomes (Figure 6A, bottom panel) and measured the abundance of specific mRNAs in each fraction using SYBR Fast quantitative PCR (qPCR)"
] | {
"all_images_paths": [
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"tampered": true,
"paper_ids": [
"2010000169"
],
"panel_ids": [
"None"
],
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010010402_TII_02/figure/2010010402_TII_02_3.png | consistency_12 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | MeRIP-seq analysis of four RNAs tested for m⁶A status in this work. These include one lncRNA, TUG1 (A), and three mRNAs: ACTB (B), TPT1 (C), and BSG (D), analyzed in three different human cell lines (HeLa, HepG2, and HEK293T). SCARLET-tested sites are marked with bold arrows. Sites that tested positive for m⁶A are indi... | We also determined the m6A status in many RRACH sites in another lncRNA (TUG1) and three mRNAs (ACTB, TPT1, and BSG), chosen on the basis of the m6A/MeRIP-seq results (Fig. 4). Among the sixteen sites tested, only four showed m6A modification >5% (Table 2). This result shows that the previously reported 20% m6A modific... | related_sentences | [
"suggests that many sites in mRNA carry complete m6A modification"
] | [
"suggests that many sites in mRNA carry incomplete m6A modification"
] | {
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"paper_ids": [
"2010000179"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010010436_TII_02/figure/2010010436_TII_02_0.png | consistency_13 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | mAtg9 affects autophagy at an early omegasome stage. (A) Domain structure of yeast and human Atg9. Red and blue boxes represent conserved transmembrane domains. (B) HEK293 cells were treated with either control siRNA (ctrl) or siRNA against mAtg9 (Atg9 KD) and incubated in full (F) or starvation medium (S) for 2 h. Cel... | Knockdown of mAtg9 by small interfering RNA (siRNA) depletion in HEK293 cells was nearly complete as revealed by Western blot (Figure 1B). As expected, depletion of mAtg9 significantly reduced lipidation of endogenous LC3 (Figure 1B) and the number of autophagic structures positive for GFP-LC3 (Figure 1C and I) observe... | related_sentences | [
"In cells depleted of mAtg9, although the total number of these structures was slightly reduced (Figure 1, D–H)"
] | [
"In cells depleted of mAtg9, although the total number of these structures was greatly reduced (Figure 1, D–H)"
] | {
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"paper_ids": [
"2010000181"
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010102051_TII_01/figure/2010102051_TII_01_0.png | consistency_14 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 1. Cavin-1 altered EV proteins and EV miR-148a with no effect on total cellular levels. (A) EVs and whole cell lysates (WCL) were collected from GFP-PC3 and cavin-1-PC3 cells and analysed by Western blot with the indicated antibodies. EV preparations were free from ER protein calnexin. Equal loading was shown by C... | To confirm the cavin-1 effect on the EV-mediated release of these proteins, and to determine whether cavin-1 affected total protein expression or only the release as we previously reported for cytokines (18), we compared the levels of selected proteins in the WCL and EVs from GFP-PC3 and cavin-1-PC3 cells by immunoblot... | related_sentences | [
"qPCR performed revealed that PC3-EV miRNA-148a levels were significantly reduced by 8.68±0.01-fold (p ≤ 0.02) upon cavin-1 expression without altering total cellular miR-148a levels"
] | [
"qPCR performed revealed that PC3-EV miRNA-148a levels were significantly reduced by 3.67±0.01-fold (p ≤ 0.02) upon cavin-1 expression without altering total cellular miR-148a levels"
] | {
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text_image_inconsistency/numerical/2010030787_TII_01/figure/2010030787_TII_01_4.png | consistency_15 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Detection of heroin and fentanyl using aptamer-based dye-displacement assays. (A) Secondary structures of HM20 and F17 based on NUPACK predictions. (B) Scheme of the dye-displacement assay using HM20, F17, and MTC (purple bars indicate monomeric/dimeric forms of the dye; blue bars indicate J-aggregates). (C) Photograph... | Notably, the presence of heroin can be clearly identified at concentrations as low as 16 μM with the naked eye via a purple-to-blue-green color change (Figure 4C), which is sufficiently sensitive for detecting opioids in seized drug samples. We then determined the specificity of the assay against a variety of ligands c... | related_sentences | [
"the presence of heroin can be clearly identified at concentrations as low as 16 μM with the naked eye via a purple-to-blue-green color change"
] | [
"the presence of heroin can be clearly identified at concentrations as low as 8 μM with the naked eye via a purple-to-blue-green color change"
] | {
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"2010000190"
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"None"
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} | ||
text_image_inconsistency/trend/2010039761_TII_02/figure/2010039761_TII_02_1.png | consistency_16 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Confirmation of SYNJ2 interaction with select binding partners. (A) SYNJ2 interacts with Lyn. HEK293 cells were transiently co-transfected with expression plasmids for Lyn or SYNJ2 or transfected with a SYNJ2 plasmid alone. Cells were lysed 24 h post-transfection. Cell lysates were incubated with an anti-Lyn ... | To confirm the interaction of SYNJ2 with Src family kinases in a cellular setting, we performed co-expression of full length SYNJ2 together with full length Lyn or Fyn in HEK293 cells. Immunoprecipitation of Lyn or Fyn from lysates of co-expressing cells, but not from cells in which SYNJ2 was overexpressed on its own, ... | related_sentences | [
"SYNJ2 non-immunoprecipitated with cortactin from HEK293 cells co-expressing full length versions of both SYNJ2 and cortactin (Fig. 2E)",
"We obtained opposite results for the interaction of SYNJ2 with intersectin (Fig. 2C)"
] | [
"SYNJ2 co-immunoprecipitated with cortactin from HEK293 cells co-expressing full length versions of both SYNJ2 and cortactin (Fig. 2E)",
"We obtained similar results for the interaction of SYNJ2 with intersectin (Fig. 2C)"
] | {
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"2010000203"
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"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010064648_TII_01/figure/2010064648_TII_01_0.png | consistency_17 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Epigenetic marks that are influenced by EBNA3A and EBNA3C during the repression of BIM by EBV. (A) The levels of BIM protein (whose predominant isoform is the extra-large BIMEL) were assayed by western blotting protein extracts from BL31 cell lines. BIM levels in uninfected BL31 or BL31 infected with the wild... | In order to investigate the roles of EBNA3A and EBNA3C in the regulation of cellular gene expression, a panel of cell lines based on the EBV-negative BL-derived line BL31 were established and characterized (50,53). Here a selection of these were subjected to western blot analysis to confirm our previous observation tha... | related_sentences | [
"Flanking the BIM transcription start site (TSS) is a remarkably large CGI that extends for 13 kb",
"across a region extending from 4 kb upstream of the BIM TSS to the start codon—indicating that here histone modification was the most likely mode of repression"
] | [
"Flanking the BIM transcription start site (TSS) is a remarkably large CGI that extends for 6 kb",
"across a region extending from 8 kb upstream of the BIM TSS to the start codon—indicating that here histone modification was the most likely mode of repression"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010064648_TII_01/figure/2010064648_TII_01_0.png"
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"tampered": true,
"paper_ids": [
"2010000205"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010065393_TII_02/figure/2010065393_TII_02_0.png | consistency_18 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. C-trapping of FACT. (A) Immunoblotting of soluble protein extracts and chromatin pellets of HT1080 cells treated with CBL0137 for 1 h, probed with the indicated antibodies. (B) Immunofluorescence staining of HT1080 cells with antibodies to SSRP1. (C) Fluorescent imaging of two live cells expressing GFP-tagged... | RESULTS FACT binds to unfolding chromatin in CBL0137-treated cells Using biochemical fractionation and fluorescent microscopy we previously demonstrated that curaxin treatment causes a rapid transition of FACT from the nucleoplasm to a state of tight association with chromatin (13). We named this phenomenon ‘chromatin ... | related_sentences | [
"the chromatin itself remains such that it appears as thicker fibers with bead like structures contouring nucleoli (Figure 2A and B)."
] | [
"the chromatin itself changes such that it appears as thicker fibers with bead like structures contouring nucleoli (Figure 2A and B)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010065393_TII_02/figure/2010065393_TII_02_0.png"
],
"tampered": true,
"paper_ids": [
"2010000221"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010005464_TII_02/figure/2010005464_TII_02_1.png | consistency_19 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. XRK3F2 plus bortezomib combination activates multiple death pathways and overcomes apoptosis resistance in mul-tiple myeloma. MM.1S cells treated with XRK3F2 (5 μM), bortezomib (Btz) (3 nM), or combined XRK3F2-Btz (5 μM/3 nM) for 24 hours in the presence or absence of autophagy inhibitor BafilomycinA1 (Baf, 4... | Btz decrease p62 levels by inducing de novo p62 expressionand preventing its degradation.In agreement with the pre-vious studies,:: we found that Btz increased levels of p62mRNA 8-fold and protein (Figure 2D; Online SupplementaryFigure S2D)independent of autophagy since changes inLC3l-LC3ll conversion were not found in... | related_sentences | [
"Btz decrease p62 levels by inducing de novo p62 expressionand preventing its degradation",
"34 XRK3F2 alone or in combination with Btz decreased LC3l-LC3ll conversion in MM1S"
] | [
"Btz increases p62 levels by inducing de novo p62 expressionand preventing its degradation",
"34 XRK3F2 alone or in combination with Btz increased LC3l-LC3ll conversion in MM1S"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010005464_TII_02/figure/2010005464_TII_02_1.png"
],
"tampered": true,
"paper_ids": [
"2010000232"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010042289_TII_02/figure/2010042289_TII_02_8.png | consistency_20 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 5 (A) Immunofluorescence staining of GIG on expression of ABCB4 and BSEP in ANIT-treated rats’ liver tissues. (B) The relative percentage of ABCB4 expression. (C) The relative percentage of BSEP expression. Red represents ABCB4, and green represents BSEP. **P<0.01, ****P<0.0001. | Effect of GIG on ABCB4 and BSEP Protein Expression in ANIT-Treated Rats. Compared with the normal control group, there was almost the high expression of ABCB4 and BSEP in the model group’s liver tissues (Figure 5). Compared with the model group, the expression of BSEP and ABCB4 decreased significantly in the GIG middle... | related_sentences | [
"there was almost the high expression of ABCB4 and BSEP in the model group’s liver tissues (Figure 5)",
"the expression of BSEP and ABCB4 decreased significantly in the GIG middle and high dose groups",
"and the changes of BSEP and ABCB4 expression showed a negative correlation with the dose of GIG (Figure 5)"
... | [
"there was almost the low expression of ABCB4 and BSEP in the model group’s liver tissues (Figure 5)",
"the expression of BSEP and ABCB4 increased significantly in the GIG middle and high dose groups",
"and the changes of BSEP and ABCB4 expression showed a positive correlation with the dose of GIG (Figure 5)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010042289_TII_02/figure/2010042289_TII_02_8.png"
],
"tampered": true,
"paper_ids": [
"2010000234"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010104828_TII_02/figure/2010104828_TII_02_0.png | consistency_21 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1 The expression of miR-29c-3p and LIF in UC tissues and IECs. (A) The mRNA levels of LIF in UC and normal tissues. (B) Representative Western blots and densitometric quantitative analysis of LIF protein levels in UC and normal tissues. (C) The mRNA levels of LIF in primary IECs of UC and normal colon. (D) Repre... | ResultsThe Expression of miR-29c-3p and LIF in UC Tissues and Primary IECsColonic biopsies were obtained during endoscopic examinations. We first assessed LIF expression in colon tissues using qRT-PCR and found it to be upregulated in UC patients compared with healthy controls (Figure 1A). The weakened LIF protein expr... | related_sentences | [
"The weakened LIF protein expression was then verified by Western blotting (Figure 1B)",
"miR-29c-3p was upregulated both in colonic tissues and IECs from UC patients relative to normal controls"
] | [
"The enhanced LIF protein expression was then verified by Western blotting (Figure 1B)",
"miR-29c-3p was downregulated both in colonic tissues and IECs from UC patients relative to normal controls"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010104828_TII_02/figure/2010104828_TII_02_0.png"
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"tampered": true,
"paper_ids": [
"2010000257"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010012624_TII_02/figure/2010012624_TII_02_3.png | consistency_22 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | R-Ras2/TC21 regulates the timely development of the pubertal mammary gland. (A) qRT-PCR analysis of total RNA obtained from mammary glands extracted from the indicated stages. Prepubertal, pubertal, and adult virgins correspond to samples obtained from 3-, 8-, and 14-wk-old RRas2+/+ female mice, respectively. Early and... | We found no major differences in any of those parameters in the mammary glands of 4-wk-old R-Ras2/TC21-deficient and control mice (Figure 3B, 3C, 3E, and 3F). However, when we analyzed 5-wk-old mice, we observed that the mammary glands extracted from RRas2−/− mice were significantly smaller than those obtained from con... | related_sentences | [
"we found that ∼50% of the mammary glands obtained from RRas2−/− mice still contained a insignificant number of TEBs (Figure 3E)",
"Those glands also displayed significantly higher numbers of TEBs (Figure 3B and 3E) and branching points (Figure 3B and 3F)"
] | [
"we found that ∼50% of the mammary glands obtained from RRas2−/− mice still contained a significant number of TEBs (Figure 3E)",
"Those glands also displayed significantly lower numbers of TEBs (Figure 3B and 3E) and branching points (Figure 3B and 3F)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010012624_TII_02/figure/2010012624_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010000263"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010122902_TII_02/figure/2010122902_TII_02_3.png | consistency_23 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Tissue penetration of Humabodies with and without albumin in spheroids. Spheroids show cell nuclei (blue) and fluorescent drug (green). Incubations included 20 nM J591 antibody, monovalent-HLE Humabody, PSMA-CD137 with MSA binding HLE (mHLE) incubated with and without MSA, PSMA-CD137 with HSA binding HLE (hHLE) incubat... | Given the importance of tissue penetration, we next investigated the impact of albumin binding on diffusion. In theory, the diffusion of a Humabody-albumin complex (~110 kDa) would be slower than the Humabody alone (~45 kDa), which could reduce tissue penetration. The impact of albumin binding on tissue distribution wa... | related_sentences | [
"an equal molar amounts of J591 antibody (~150 kDa) resulted in homogeneous distribution"
] | [
"an equal molar amounts of J591 antibody (~150 kDa) resulted in heterogeneous distribution"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010122902_TII_02/figure/2010122902_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010000275"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010162117_TII_02/figure/2010162117_TII_02_8.png | consistency_24 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 7 (A and B) The BAL fluids and lungs were harvested 24 h after last rmIL-33 challenge to measure the protein expression of IL-1α, IL-5, IL-13, CCL11, CCL17, CCL22 and CCL24. (C) Cell differentials from BAL fluids harvested 24 h after the last rmIL-33 challenge. The results are shown as mean ± SEM of four mice in... | We assessed cell differentials and cytokine and chemokine expression levels in the BAL fluid and lung homogenates 24 h after rmIL-33 challenge for four consecutive days (Figure 6A). IL-1α protein expression was not changed by exogenous rmIL-33 challenge in lung homogenate (Figure 7A). This result is consistent with a p... | related_sentences | [
"and TSA treatment significantly increased the rmIL-33-induced IL-5 and IL-13 protein expression compared with TSA–vehicle treatment (p < 0.05) (Figure 7B)"
] | [
"and TSA treatment significantly decreased the rmIL-33-induced IL-5 and IL-13 protein expression compared with TSA–vehicle treatment (p < 0.05) (Figure 7B)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010162117_TII_02/figure/2010162117_TII_02_8.png"
],
"tampered": true,
"paper_ids": [
"2010000289"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010147815_TII_01/figure/2010147815_TII_01_3.png | consistency_25 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 4. Binding of a2NTD and intracellular cytokine production in monocyte subpopulations. (A–D) Peripheral blood mononuclear cells (PBMCs) were incubated with 10 μg/mL a2NTD conjugated to Alexa Fluor 488 (a2NTD-AF488) for 1 h and then surface stained with anti-CD14-Pacific Blue and anti-CD16-PE antibodies. (A) Perce... | Uptake of a2NTD by monocyte subsets. To determine if different monocyte subsets preferentially internalize a2NTD, monocytes were stained for the surface markers CD14 and CD16 after incubation with a2NTD. CD14++CD16− cells constitute the majority of all monocytes, while CD14++CD16+ and CD14+CD16++ represent two minor su... | related_sentences | [
"as compared with approximately 90% of CD14++CD16− monocytes",
"nearly 80% of CD14++CD16+ monocytes were positive for a2NTD endocytosis,"
] | [
"as compared with approximately 45% of CD14++CD16− monocytes",
"nearly 100% of CD14++CD16+ monocytes were positive for a2NTD endocytosis,"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010147815_TII_01/figure/2010147815_TII_01_3.png"
],
"tampered": true,
"paper_ids": [
"2010000290"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041524_TII_02/figure/2010041524_TII_02_5.png | consistency_26 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Reduced GRHL2 level triggers expression of EDC proteins in differentiating keratinocytes. (a) Rapidly proliferating NHEK were serially subcultured until senescence, and western blotting was performed at varying PD levels for GRHL2, IVL, Jmjd3, and p16INK4A.(b) NHEK were exposed to 1.5mM Caþþfor up to 3 days and collect... | To understand the mechanism by which GRHL2 inhibits EDC gene expression and keratinocyte differentiation, we explored the functional relationship between GRHL2 and epigenetic gene regulation by Jmjd3. In NHEK with increasing PDs, GRHL2 levels progressively decreased while the levels of IVL and p16INK4A decreased (Figur... | related_sentences | [
"GRHL2 levels progressively decreased while the levels of IVL and p16INK4A decreased (Figure 5a)"
] | [
"GRHL2 levels progressively decreased while the levels of IVL and p16INK4A increased (Figure 5a)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041524_TII_02/figure/2010041524_TII_02_5.png"
],
"tampered": true,
"paper_ids": [
"2010000345"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041695_TII_02/figure/2010041695_TII_02_4.png | consistency_27 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure2 Roles of ALK5 receptor and ROS in TGF-b-induced apoptosis in HUVECs. (a) Effects of the ALK5 inhibitor SB431542 (2mM) on TGF-b (10ng/ml for 24h)induced caspase 3/7 activation. (b) Effects of SB431542 on TGF-b-induced caspase 3 cleavage. (c) Effects of SB431542 on TGF-b-induced DCm depression (reduced red fluore... | TGF-b-induced apoptosis is dependent on ALK5 and ROS. To examine whether the ALK5 receptor was involved in TGF-b-induced apoptosis, HUVECs were pre-treated with the ALK5 inhibitor SB431542. Treatment with SB431542 at 2mM enhanced the apoptotic response induced by TGF-b as indicated by caspase 3/7 activation and caspase... | related_sentences | [
"Treatment with SB431542 at 2mM enhanced the apoptotic response induced by TGF-b as indicated by caspase 3/7 activation and caspase 3 cleavage (Figures 2a and b)"
] | [
"Treatment with SB431542 at 2mM abolished the apoptotic response induced by TGF-b as indicated by caspase 3/7 activation and caspase 3 cleavage (Figures 2a and b)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041695_TII_02/figure/2010041695_TII_02_4.png"
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"tampered": true,
"paper_ids": [
"2010000346"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010031950_TII_01/figure/2010031950_TII_01_0.png | consistency_28 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Morphological and growth characterization of hBMCs and hPDCs. (A) Growth curves of hBMCs (human bone marrow derived cells) and hPDCs (human periosteum-derived cells) over 2 weeks in culture. (B) Phase contrast images of hBMCs and hPDCs at one day after seeding at 5 k/cm2, 25 k/cm2, and 85 k/cm2 (scale bar 5 100 mm). Wh... | Independently of the cell culture vessel used, hPDCs proliferated faster than hBMCs and reached full confluence after 7 days (Fig. 1A) when initially seeded at low seeding density (5000 cells/cm2). In addition, the cell density of hPDCs obtained at confluence was consistently higher as compared to hBMCs, which suggeste... | related_sentences | [
"hPDCs proliferated faster than hBMCs and reached full confluence after 7 days (Fig. 1A) when initially seeded at low seeding density (5000 cells/cm2)"
] | [
"hPDCs proliferated faster than hBMCs and reached full confluence after 10 days (Fig. 1A) when initially seeded at low seeding density (5000 cells/cm2)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010031950_TII_01/figure/2010031950_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010000350"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010168986_TII_02/figure/2010168986_TII_02_2.png | consistency_29 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | FIGURE 3. Co-i-cIDPRE evokes Ca2+ increase in human Jurkat cells after UV photolysis. A, Co-i-cIDPRE (200 µM) incited much weaker Ca2+ increases after UV photolysis than that by cIDPRE (200 µM) in Jurkat cells. Fluo-4-loaded cells were incubated in regular HBSS containing extracellular Ca2+ during the experiment. B, af... | It has been shown that cADPR targets the RyR, but which specific isoform it targets remains to be determined (1–3). Here we showed that both RyR2 and RyR3 are expressed in Jurkat cells. Individual knockdown of these isoforms inhibited cIDPRE- or cADPR-induced Ca2+ release to a similar extent, whereas double knockdown o... | caption | [
"Co-i-cIDPRE (200 µM) incited much weaker Ca2+ increases after UV photolysis than that by cIDPRE (200 µM) in Jurkat cells.",
"thapsigargin (10 µM) pretreatment promoted Co-i-cIDPRE (120 µM)-induced Ca2+ increases in the absence of extracellular Ca2+."
] | [
"Co-i-cIDPRE (200 µM) incited much stronger Ca2+ increases after UV photolysis than that by cIDPRE (200 µM) in Jurkat cells.",
"thapsigargin (10 µM) pretreatment abolished Co-i-cIDPRE (120 µM)-induced Ca2+ increases in the absence of extracellular Ca2+."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010168986_TII_02/figure/2010168986_TII_02_2.png"
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"paper_ids": [
"2010000351"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041443_TII_02/figure/2010041443_TII_02_3.png | consistency_30 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4 ‘Late’ Hsp27 phosphorylation induced by apigenin is modulated by p38-MAPK and PKCd. Lysates from THP-1 cells treated with 50 μM apigenin for 6 h and diluent or following 1 h pretreatment with 10 μM SB203580, 15 μM rottlerin, or both. Treatments marked with (-) denote addition of diluent. (a) Immunoblots with a... | Next, we investigated the role of p38 and PKCσ on the ‘late’ Hsp27 phosphorylation using pharmacological inhibitors. THP-1 cells were pretreated with the p38 inhibitor SB203580, or the PKCσ inhibitor rottlerin, or both inhibitors, or with diluent for 1 h before the addition of 50 μM apigenin for 6 h. We found that apig... | related_sentences | [
"We found that apigenin-induced phosphorylation of S78 was significantly stimulated in the presence of the p38 inhibitor SB203580 (Figure 4a, lane 3 versus 2, **P<0.001)"
] | [
"We found that apigenin-induced phosphorylation of S78 was significantly inhibited in the presence of the p38 inhibitor SB203580 (Figure 4a, lane 3 versus 2, **P<0.001)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041443_TII_02/figure/2010041443_TII_02_3.png"
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"tampered": true,
"paper_ids": [
"2010000354"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010065512_TII_01/figure/2010065512_TII_01_2.png | consistency_31 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 3. Expression of histone mRNAs in mouse fibroblast cells and mouse liver. (A) Schematic of generalized S1 nuclease protection assay performed on mouse histone mRNA. A generalized histone mRNA is depicted indicating possible 5’ splice sites (5’ss), stem-loop cleavage sites (S-L cleavage) or poly(A) cleavage sites... | Validation of polyadenylated histone mRNA expression in adult mouse liver. To confirm the expression of the mouse histone mRNAs detected by high-throughput sequencing, we analysed histone gene expression in actively growing cultured fibroblasts (NIH3T3 cells) and liver tissue from 72-week-old mice. The liver is a relat... | related_sentences | [
"most of the 3' S1 probes map three protected fragments: one extending to the 3' end of the mRNA ending in the stem-loop and a second fragment"
] | [
"most of the 3' S1 probes map two protected fragments: one extending to the 3' end of the mRNA ending in the stem-loop and a second fragment"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010065512_TII_01/figure/2010065512_TII_01_2.png"
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"tampered": true,
"paper_ids": [
"2010000358"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010011052_TII_01/figure/2010011052_TII_01_0.png | consistency_32 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Production of Th2- and Th1-type cytokines from wild-type and Runt-transgenic CD4⁺ T cells. (A) Naive CD4⁺ T cells were isolated from the spleens of wild-type and Runt–transgenic mice and stimulated with anti-CD3/anti-CD28 antibodies, and the culture supernatants were collected at the indicated times after stimulation. ... | Respectively, compared with the wild-type cells. A similar result as that shown in Figure 1A was obtained when the TCR-stimulated cells were incubated in the presence of IL-2 for 5 d, washed with fresh media, and restimulated via TCR (Figure 1B). Under this neutral culture condition where neither IL-4 nor IL-12 was add... | related_sentences | [
"In the Th2 condition, the Runt-transgenic cells produced three times as much IL-4 as the wild-type cells",
"even in the Th1 condition, the Runt-transgenic cells actually produced 10 times as much IL-4 as the wild-type cells (Figure 1D)"
] | [
"In the Th2 condition, the Runt-transgenic cells produced eight times as much IL-4 as the wild-type cells",
"even in the Th1 condition, the Runt-transgenic cells actually produced 25 times as much IL-4 as the wild-type cells (Figure 1D)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010011052_TII_01/figure/2010011052_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010000365"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010064426_TII_02/figure/2010064426_TII_02_4.png | consistency_33 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 5. Reporter assay tests for the repression of NL4-3 by miR-223 and miR-29. For all transfections, the values represent the average of at least three independent experiments and the error bar represents the standard deviation. (a) Reporter assays show miR-223/29 repression is very weak when Nef serves as the 30 -... | No words | caption | [
"Co-transfection of the reporter and miRNA genes in HEK-293 cells show strong repression by miR-223 and strong repression by miR-29",
"Co-transfection of the reporter and miRNA expression constructs in HEK-293 cells show strong repression mediated by miR-223 and reduced repression mediated by the miR-29 miRNAs"
... | [
"Co-transfection of the reporter and miRNA genes in HEK-293 cells show weak repression by miR-223 and strong repression by miR-29",
"Co-transfection of the reporter and miRNA expression constructs in HEK-293 cells show weak repression mediated by miR-223 and reduced repression mediated by the miR-29 miRNAs"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010064426_TII_02/figure/2010064426_TII_02_4.png"
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"tampered": true,
"paper_ids": [
"2010000368"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010064989_TII_02/figure/2010064989_TII_02_8.png | consistency_34 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 9. Activity and selectivity of ASOs in the rodent CNS. (A) Allele selective knockdown of muHTT protein with ASO A30 in neuronal cells derived from cortical and striatal tissues of Hu97/18 mouse embryos under free-uptake conditions. (B–D) Hu97/18 mice (n = 4/group) were injected ICV with a single dose of 300 µg o... | Improved allele selectivity in cell culture translates to brains of transgenic mice. We evaluated selected ASOs in Hu97/18 mice (45), a completely humanized mouse model of HD (Figure 9). This mouse model contains both the mutant human HTT allele, with the associated SNPs, and the wt human HTT allele. We first evaluated... | caption | [
"and A31 show similar activity but worsened allele selectivity relative to control ASO A1."
] | [
"and A31 show similar activity but improved allele selectivity relative to control ASO A1."
] | {
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"2010000374"
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text_image_inconsistency/trend/2010131195_TII_02/figure/2010131195_TII_02_3.png | consistency_35 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. Reversion of Splicing Abnormalities in DM1 Patient-Derived Muscle Cells by CRISPR-SaCas9 Deletion of Expanded CTG Repeats Splicing profiles and quantification of LDB3 exon 11-, ATP2A1 exon 22-, MBNL1 exon 7-, DMD exon 78-, INSR exon 11-, and BIN1 exon 11-containing transcripts in differentiated myoblasts from... | Aggravation of Alternative Splicing Defects in DM1-Edited Muscle Cells Sequestration of MBNL-splicing factors in nuclear foci of DM1 cells leads to alterations in the alternative splicing of numerous pre-mRNAs, some of which are eliminated in differentiated muscle cells in culture.45 We therefore assessed the splicing ... | related_sentences | [
"Aggravation of Alternative Splicing Defects in DM1-Edited Muscle Cells Sequestration of MBNL-splicing factors in nuclear foci of DM1 cells leads to alterations in the alternative splicing of numerous pre-mRNAs",
"some of which are eliminated in differentiated muscle cells in culture"
] | [
"Correction of Alternative Splicing Defects in DM1-Edited Muscle Cells Sequestration of MBNL-splicing factors in nuclear foci of DM1 cells leads to alterations in the alternative splicing of numerous pre-mRNAs",
"some of which are reproduced in differentiated muscle cells in culture"
] | {
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"2010000376"
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"None"
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} | ||
text_image_inconsistency/trend/2010101726_TII_02/figure/2010101726_TII_02_1.png | consistency_36 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Overexpression of Ahi-1 in Sca-1 +lin _x0004_ mouse stem/progenitor BM cells perturbs their in vitro proliferative activity and enhances the effects of BCR-ABL. (A) The levels of Ahi-1 transcripts relative to GAPDH from FACS-purified MIY (Sca-1 + lin _x0004_ YFP +), Ahi-1 (Sca-1 + lin _x0004_ YFP +), BCR-ABL ... | Elevated endogenous Ahi-1 expression was also observed in cells transduced with BCR-ABL alone as compared with control cells (8-fold; P < 0.01; Fig. 2 A). 5 d after transduction, the rate of expansion of the Sca-1 +lin _x0004_YFP + (Ahi-1 +) cells in liquid cultures was approximately twofold lower than in cultures init... | related_sentences | [
"the rate of expansion of the Sca-1 +lin _x0004_YFP + (Ahi-1 +) cells in liquid cultures was approximately twofold lower than in cultures initiated with control cells (Fig. 2 B)",
"Ahi-1– transduced Sca-1 +lin _x0004_ cells produced a slightly fewer number of colony-forming cells (CFCs) than MIY-transduced contro... | [
"the rate of expansion of the Sca-1 +lin _x0004_YFP + (Ahi-1 +) cells in liquid cultures was approximately twofold higher than in cultures initiated with control cells (Fig. 2 B)",
"Ahi-1– transduced Sca-1 +lin _x0004_ cells produced a slightly greater number of colony-forming cells (CFCs) than MIY-transduced con... | {
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"2010000382"
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"None"
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"None"
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} | ||
text_image_inconsistency/numerical/2010016919_TII_01/figure/2010016919_TII_01_2.png | consistency_37 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | ECM softness upregulates MMP secretion and promotes MMP activity. (A) Primary human fibroblasts (2 × 104 cells per well) were seeded onto gels of varying stiffness in 12-well plates and cultured for 48 h. Cell culture medium from each condition was collected and subject to the RayBio Human MMP Array to determine the to... | Matrix metalloproteinases (MMPs) are critical proteinases in ECM degradation and include two major subfamilies of secreted MMPs (MMP-2, -3, etc.) and integral membrane MMPs (MMP-14 [MT1-MMP], -15, etc.; Kessenbrock et al., 2010). For all types of MMPs that were measured, increased ECM stiffness significantly inhibited ... | caption | [
"Student’s t test was used for the comparison of each mean with the mean of “0.4 kPa.” *p < 0.05 considered significant",
"Student’s test was used for the comparison of each mean with the mean of MMP protein quantity of the same MMP type on 25.6-kPa gels."
] | [
"Student’s t test was used for the comparison of each mean with the mean of “0.1 kPa.” *p < 0.05 considered significant",
"Student’s test was used for the comparison of each mean with the mean of MMP protein quantity of the same MMP type on 0.2-kPa gels."
] | {
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"2010000398"
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} | ||
text_image_inconsistency/trend/2010124149_TII_02/figure/2010124149_TII_02_3.png | consistency_38 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. Quantitative analysis of CTCF and BORIS expression in human PCa. (A) Nuclear CTCF significantly decreases in metastases cores (P < .001). (B) BORIS nuclear expression significantly increased in cancer cores (P = .002); nuclear and cytoplasmic expression increased in HGPIN cores compared to benign (both P < .0... | CTCF is known to impact gene regulation through the management of chromatin organization and the maintenance of epigenetic marks [26]. CTCF expression levels measured by VECTRA were insignificantly decreased in metastatic PCa tumors (P < .001), but not localized PCa when compared to benign prostate tissues (P = .17) (F... | caption | [
"CTCF expression levels measured by VECTRA were insignificantly decreased in metastatic PCa tumors (P < .001)",
"high Gleason grade cancers have significantly lower BORIS/CTCF ratio than both benign and intermediate Gleason cores (P = .006 and P = .024 respectively)"
] | [
"CTCF expression levels measured by VECTRA were significantly decreased in metastatic PCa tumors (P < .001)",
"high Gleason grade cancers have significantly higher BORIS/CTCF ratio than both benign and intermediate Gleason cores (P = .006 and P = .024 respectively)"
] | {
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"2010000399"
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"None"
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text_image_inconsistency/trend/2010011326_TII_02/figure/2010011326_TII_02_2.png | consistency_39 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Effects of TRAF3 deficiency on effector functions of CD40 and LMP1. (A) A20.2J cells stably transfected with hCD40LMP1 were stimulated with 2 µg/ml anti-mCD40 Ab (CD40), anti-hCD40 Ab to trigger signaling through hCD40LMP1 (LMP1), or isotype control Abs for each (iso1 and iso2) for 48 h. Expression of CD23, CD80, and C... | Effects of TRAF3 Deficiency on Effector Functions. Next, we determined if the effects of TRAF3 deficiency on early signaling pathways of CD40 and LMP1 are predictive of downstream B cell effector functions, including upregulation of surface molecules and secretion of cytokines and antibodies. After CD40 engagement, TRA... | related_sentences | [
"Although we consistently observed a partial increase in CD40-mediated upregulation of CD80 in TRAF3⁻/⁻ B cells (Figure 3A)"
] | [
"Although we consistently observed a partial decrease in CD40-mediated upregulation of CD80 in TRAF3⁻/⁻ B cells (Figure 3A)"
] | {
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"2010000405"
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"None"
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} | ||
text_image_inconsistency/trend/2010104844_TII_02/figure/2010104844_TII_02_3.png | consistency_40 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4 The effects of hydrogels on skin wound healing in type 2 diabetes mellitus (T2D) by topical treatment. (A) Representative images of wounds in the normal control (NC) group, T2D group, CAH (T2D+CAH) group, and CAVBPH (T2D+CAVBPH) group on days 0, 3, 9, and 15. (B) Wound healing rate. *p < 0.05, **p < 0.01, and ... | As shown in Figure 4A, the wound size in all groups decreased gradually over time. Compared with the NC group, the T2D group displayed a slower wound shrinkage due to the influence of diabetes, and exudate was still found on the wound surface on day 9. Topical application of CAH and CAVBPH significantly accelerated dia... | related_sentences | [
"The healing rate in the T2D group was more optimistic than that in the NC group (p < 0.01 or p < 0.001)"
] | [
"The healing rate in the T2D group was less optimistic than that in the NC group (p < 0.01 or p < 0.001)"
] | {
"all_images_paths": [
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} | ||
text_image_inconsistency/trend/2010184705_TII_02/figure/2010184705_TII_02_0.png | consistency_41 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. Telomeric element HeT-A expression is downregulated in ovaries by Trf2, Woc and Ars2. (A) RT-qPCR analysis of TE expression in ovaries of Trf2KDnos, wocKDnos and Ars2KDnos. (B) HeT-A transcript abundance in ovaries of Trf2/Trf2, spnE/spnE and Trf2,spnE double mutants. The fold change in the HeT-A RNA level is... | RESULTS Trancription factors Woc and Trf2 suppress telomeric repeat HeT-A transcription in ovaries In order to detect germline components contributing to telomeric homeostasis, we performed a selective RNAi screen for factors that downregulate HeT-A expression in Drosophila ovaries. This approach was based on the exist... | related_sentences | [
"RT-qPCR analysis of telomeric and non-telomeric retrotransposon expression demonstrated decreased levels of HeT-A and TAHRE transcripts in ovaries upon germline knockdown of Trf2 (Trf2KDnos; nos designates the promoter of the germline-specific gene nanos that was used to express the Gal4 driver) (Figure 1A)"
] | [
"RT-qPCR analysis of telomeric and non-telomeric retrotransposon expression demonstrated increased levels of HeT-A and TAHRE transcripts in ovaries upon germline knockdown of Trf2 (Trf2KDnos; nos designates the promoter of the germline-specific gene nanos that was used to express the Gal4 driver) (Figure 1A)"
] | {
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"2010000418"
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"None"
],
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010011530_TII_02/figure/2010011530_TII_02_4.png | consistency_42 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Agrin-mediated decrease in gap junction–dependent intercellular communication between chromaffin cells in neonates. (A) Reduced number of electrically and LY-coupled chromaffin cells in neonatal agrin-treated slices. *, P ≤ 0.01 when compared with control slices. (B) Monitoring of electrical coupling between chromaffin... | Studies were next undertaken to examine the effect of agrin on both gap junction–mediated electrical and metabolic coupling between neonate chromaffin cells. Metabolic coupling was assessed using Lucifer yellow (LY) to label coupled cells, whereas electrical coupling was evidenced by dual whole-cell patch-clamp recordi... | caption | [
"A weak coupling was less frequently observed in agrin-treated slices."
] | [
"A robust coupling was less frequently observed in agrin-treated slices."
] | {
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"2010000421"
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"None"
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"None"
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text_image_inconsistency/trend/2010007150_TII_02/figure/2010007150_TII_02_1.png | consistency_43 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | FIGURE 2. Fold enrichment of selenoprotein mRNAs on UPF1 in low versus high Se.(A) Levels of selenoprotein mRNAs that coprecipitated with UPF1, following culturing HEK293T cells in 3 nM Se or 60 nM Se. Transcript levels are normalized to a synthetic in vitro transcribed RNA and then to the value of the corresponding sa... | We reasoned that if the transcripts that decreased in low Se were undergoing NMD, then they should similarly be enriched on UPF1. The same experiment modeling conditions of low Se was repeated, and RNA immunoprecipitation was performed with UPF1. The cytoplasmic nucleoprotein complexes were coimmunoprecipitated with an... | related_sentences | [
"RNAs predicted resistant to NMD showed a difference in their abundance on UPF1 with respect to Se",
"were also the less abundantly bound to UPF1 under conditions of low Se (Fig. 2A)"
] | [
"RNAs predicted resistant to NMD showed no difference in their abundance on UPF1 with respect to Se",
"were also the most abundantly bound to UPF1 under conditions of low Se (Fig. 2A)"
] | {
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"None"
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} | ||
text_image_inconsistency/numerical/2010011652_TII_01/figure/2010011652_TII_01_6.png | consistency_44 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | 3D fibronectin matrix reduces both Rac activity and random migration. (A) Primary human fibroblasts were plated on 2D substrates coated with fibronectin or 3D matrices rich in fibronectin and assayed for activity as in Figure 1. The reduction of active Rac in cells plated in a 3D matrix compared with 2D was 31% (P ≤ 0.... | Cells migrating in 3D cell-derived matrices have different types of cell adhesions, morphology, and signaling when compared with cells in standard 2D tissue culture (Cukierman et al., 2001; Walpita and Hay, 2002). Human fibroblasts in such 3D matrices were found to have a partial, but highly reproducible, 10–50% reduct... | related_sentences | [
"10–50% reduction in active Rac, but no reduction or increase in Cdc42 or Rho activities (Figure 7A)",
"with directional persistence increasing from D/T₂ᴰ = 0.25 ± 0.03 to D/T₃ᴰ = 0.87 ± 0.02 (P < 0.0001)"
] | [
"30–50% reduction in active Rac, but no reduction or increase in Cdc42 or Rho activities (Figure 7A)",
"with directional persistence increasing from D/T₂ᴰ = 0.48 ± 0.03 to D/T₃ᴰ = 0.87 ± 0.02 (P < 0.0001)"
] | {
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"None"
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} | ||
text_image_inconsistency/trend/2010183324_TII_02/figure/2010183324_TII_02_4.png | consistency_45 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 5. Electrophoretic mobility shift assay results for the AZRE. (A) Sequence-specific interaction of nuclear proteins with the AZRE. The 23 bp AZRE containing a fragment between nucleotides –190 and –168 relative to the transcription start site of Oshsp17.3 was radiolabelled, and 1 ng of the probe was incubated with... | Specificity of nuclear proteins interacting with the 9 bp AZRE in vitro by EMSA. To characterize the putative AZRE further, EMSA was used to determine whether it can interact with trans-acting factor(s) present in nuclear extracts. A 23 bp synthetic oligonucleotide encompassing the AZRE was used as a probe and was labe... | related_sentences | [
"nuclear extracts prepared from seedlings treated for 6 h with AZC, Cd, As, or HS showed a lower intensity of C1 and C2 than those from control seedlings (Fig. 5D)"
] | [
"nuclear extracts prepared from seedlings treated for 6 h with AZC, Cd, As, or HS showed a higher intensity of C1 and C2 than those from control seedlings (Fig. 5D)"
] | {
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text_image_inconsistency/trend/2010127691_TII_02/figure/2010127691_TII_02_0.png | consistency_46 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. SDHB expression is high in CRC cell lines. (A) Quantitative RT-PCR analysis of SDHB mRNA expression in four colorectal cancer (CRC) cell lines compared to the normal colorectal epithelial cell line NCM460. (B) Semi-quantitative RT-PCR further confirms increased SDHB transcript levels in CRC cell lines relativ... | SDHB is the key enzymatic component of mitochondrial enzyme SDH constructively expressed across species, which oxidizes succinate to fumarate in the TCA cycle and feeds electrons into the mitochondrial respiratory chain for ATP production. We examined SDHB mRNA and protein levels in four CRC cell lines and normal color... | caption | [
"SDHB expression is high in CRC cell lines.",
"(B) Semi-quantitative RT-PCR further confirms increased SDHB transcript levels in CRC cell lines relative to NCM460.",
"As shown in Figure 1 both SDHB mRNA level and protein level were relatively high in all four CRC cell lines (SW480,"
] | [
"SDHB expression is low in CRC cell lines.",
"(B) Semi-quantitative RT-PCR further confirms reduced SDHB transcript levels in CRC cell lines relative to NCM460.",
"As shown in Figure 1 both SDHB mRNA level and protein level were relatively low in all four CRC cell lines (SW480,"
] | {
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text_image_inconsistency/trend/2010016329_TII_02/figure/2010016329_TII_02_1.png | consistency_47 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Effects of KBrO3 on mtDNA copy number and topology. (A) Dot-blot of purified mtDNA from control cells and cells treated with 30 μM KBrO3. Oxidative damage is detected using an antibody against 8-oxodG by SouthWestern analysis and normalized against total mtDNA by Southern hybridization on a separate blot. (B) Dot-blot ... | Although KBrO3 did not have as dramatic an effect on nuclear DNA damage signaling as UV or H2O2, it induced a marked increase in mtDNA damage (Figure 1A). The damage did not result in copy number depletion or any effect on the supercoiling of mtDNA (Figure 1, C and D). | caption | [
"mtDNA copy number is not unaffected by KBrO3."
] | [
"mtDNA copy number is not affected by KBrO3."
] | {
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"None"
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} | ||
text_image_inconsistency/numerical/2010064451_TII_01/figure/2010064451_TII_01_0.png | consistency_48 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Purification of chicken FANCD2, FANCI, FANCL andhuman UBE2T. (A) Purified chicken FANCD2 and FANCI, used forin vitro assays, were analyzed by 15% SDS-PAGE with CoomassieBrilliant Blue staining. Lane 1 indicates the molecular mass markers.Lanes 2 and 3 indicate purified FANCD2 and FANCD2 K563R,respectively. La... | Chicken FANCI and FANCD3 were purified as recombinant proteins (Figure 1A, lanes 3 and 4), and the IDcomplex was prepared by mixing them in 1:1 stoichiometry. We also purified UBE2T and FANCL, which areknown as the E2 and E3 proteins for FANCD2monoubiquitylation, respectively, as recombinantproteins (Figure 1B and C). | related_sentences | [
"Chicken FANCI and FANCD3 were purified as recombinant proteins (Figure 1A, lanes 3 and 4)"
] | [
"Chicken FANCI and FANCD2 were purified as recombinant proteins (Figure 1A, lanes 2 and 4)"
] | {
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"2010000598"
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"None"
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} | ||
text_image_inconsistency/numerical/2010169000_TII_01/figure/2010169000_TII_01_5.png | consistency_49 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | FIGURE 6. Incorporation of single UV photoproducts increases nucleosome dynamics. A, schematic illustration of the incorporation of a single CPD or 6-4PP into the 601 sequence. The DFs are 12-mer oligonucleotides with the sequences shown. Solid triangles indicate the positions of the photoproduct. The dark circle repre... | Taining a single CPD or 6-4PP lesion is 4.6 nm and 4.2 nm, respectively. Furthermore, in each case, the FRET efficiency is reduced, indicating that the introduction of a single UV lesion in nucleosome DNA can increase NCP unwrapping. This supports the UV dose-dependent FRET change we observed with UV-irradiated NCP DNA... | related_sentences | [
"In the range of 0–1 M salt concentrations"
] | [
"In the range of 0.25–1 M salt concentrations"
] | {
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"paper_ids": [
"2010000602"
],
"panel_ids": [
"None"
],
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010095497_TII_02/figure/2010095497_TII_02_0.png | consistency_50 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. Reduced PtdCho synthesis in CCTα-deficient macrophages. (A) Wild-type (WT; n = 12) or CCTα-deficient (KO; n = 12) macrophages were labeled for 6 h with 1 μCi/ml [3H]choline, and incorporation into PtdCho was normalized to cellular protein. (B) Relative transcript levels for CCTα, CCTβ2, CCTβ3, or PEMT were de... | Mice with CCTα-null macrophages were generated as described previously (Zhang et al., 2000). Briefly, mice carrying a floxed Pcyt1a gene were crossed with mice expressing Cre recombinase under the macrophage-specific LysM promoter. Two loxP sites flanked a 12.5-kb fragment of the Pcyt1a gene containing exons 5–9 (Karim... | related_sentences | [
"and the CCTα-deficient macrophage population showed increased rates of de novo phosphatidylcholine (PtdCho) synthesis measured by [?H]choline incorporation into the lipid fraction of adherent cells (Fig.",
"Quantitative RT-PCR (qRT-PCR) analysis revealed that the CCTα transcript level was significantly increased... | [
"and the CCTα-deficient macrophage population showed reduced rates of de novo phosphatidylcholine (PtdCho) synthesis measured by [?H]choline incorporation into the lipid fraction of adherent cells (Fig.",
"Quantitative RT-PCR (qRT-PCR) analysis revealed that the CCTα transcript level was significantly reduced to ... | {
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"None"
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} | ||
text_image_inconsistency/trend/2010065412_TII_02/figure/2010065412_TII_02_1.png | consistency_51 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Differential inhibitory effects of SAUGI on the activities of (A) SAUDG, (B) EBVUDG, (C) HSVUDG, (D) human UDG and (E) TBUDG. Except for TBUDG, addition of SAUGI increased the specific uracil-removing activity of SAUDG and the other three UDGs in a dosage-dependent manner. | The inhibiting effects of SAUGI on five UDGs We next used uracil removal assays to investigate the ability of SAUGI to inhibit the same five UDGs that were used in the surface plasmon resonance experiments. In the absence of SAUGI, all the UDGs removed the uracil from the uracil-containing DNA substrates effectively, a... | caption | [
"addition of SAUGI increased the specific uracil-removing activity of SAUDG and the other three UDGs in a dosage-dependent manner"
] | [
"addition of SAUGI reduced the specific uracil-removing activity of SAUDG and the other three UDGs in a dosage-dependent manner"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010065412_TII_02/figure/2010065412_TII_02_1.png"
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"tampered": true,
"paper_ids": [
"2010000662"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010065375_TII_01/figure/2010065375_TII_01_1.png | consistency_52 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2. HITS-CLIP reveals HIV-1 regions bound by Ago2 in HIV-1 infected cells. (A) HEK293T cells were transfected with plasmid expressing either GFP-Ago2 or control GFP. Twenty-four hours later, they were infected with VSVg-pseudotyped HIV-1 NL4-3 at a M.O.I. of 1 or mock infected. Twenty-four hours later, cells were... | Immunopurified RNAs were radiolabeled, separated on SDS-PAGE and transferred to nitrocellulose membrane. Autoradiograms revealed the presence of RNA–protein complexes migrating from 100 kDa, the expected size of GFP-Ago2, to higher molecular weights corresponding to the size distribution of RNAs associated with GFP-Ago... | related_sentences | [
"Autoradiograms revealed the presence of RNA–protein complexes migrating from 100 kDa",
"a 5-fold enrichment of mRNAs"
] | [
"Autoradiograms revealed the presence of RNA–protein complexes migrating from 125 kDa",
"a 2.5-fold enrichment of mRNAs"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010065375_TII_01/figure/2010065375_TII_01_1.png"
],
"tampered": true,
"paper_ids": [
"2010000668"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010131697_TII_01/figure/2010131697_TII_01_2.png | consistency_53 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. NTCP inhibition by Myrcludex B increases plasma bile acid and GLP-1 levels. (A) Unconjugated, conjugated, and total plasma bile acid levels 3 hours after placebo or Myrcludex B (2.5 mg/g) injection in male obese WT and Oatp1a/1b KO mice (n = 9–10). Mice were fed a HFD for 16 weeks and subsequently treated dai... | To evaluate the in vivo impact of bile acids on GLP-1 secretion, we used the NTCP inhibitor Myrcludex B to prolong bile acid signaling in obese Oatp1a/1b-deficient mice. Treatment with Myrcludex B was started 15 weeks after the onset of obesity by high-fat diet (HFD) feeding. In line with previous research, Oatp1a/1b K... | related_sentences | [
"Inhibition of NTCP by Myrcludex B increased fasting GLP-1 levels 10-fold (Figure 1B)."
] | [
"Inhibition of NTCP by Myrcludex B increased fasting GLP-1 levels 4-fold (Figure 1B)."
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010131697_TII_01/figure/2010131697_TII_01_2.png"
],
"tampered": true,
"paper_ids": [
"2010000705"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010064913_TII_02/figure/2010064913_TII_02_0.png | consistency_54 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. Clk1 enhances SPF45-induced exon 6 exclusion from Fas mRNA. (A) SKOV3 cells were transfected with siRNA against SPF45 (siSPF45) or scrambled control siRNA (scr) for 72 h, and RNA was isolated. Endogenous Fas spliced isoforms were analysed by RT-PCR using primers flanking exon 6. PCR products representing mRNA... | SPF45 enhances exon 6 exclusion from Fas pre-mRNA in a cellular minigene assay (21,33). To determine whether endogenous SPF45 has a dissimilar effect on splicing of endogenous Fas pre-mRNA, we transfected SKOV-3 ovarian cancer cells with siRNA against SPF45. Seventy-two hours after transfection, RNA was harvested, and ... | related_sentences | [
"TG003 not only promoted the increase of exon 6 exclusion induced by SPF45 (Figure 2C) but also decreased SPF45 protein expression (Figure 2D)",
"To determine whether endogenous SPF45 has a dissimilar effect on splicing of endogenous Fas pre-mRNA,"
] | [
"TG003 not only inhibited the increase of exon 6 exclusion induced by SPF45 (Figure 2C) but also decreased SPF45 protein expression (Figure 2D)",
"To determine whether endogenous SPF45 has a similar effect on splicing of endogenous Fas pre-mRNA,"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010064913_TII_02/figure/2010064913_TII_02_0.png"
],
"tampered": true,
"paper_ids": [
"2010000719"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010064871_TII_02/figure/2010064871_TII_02_1.png | consistency_55 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. T. brucei Asf1A is nuclear, whereas Asf1B is sporadically cytosolic. Panels (A) and (B) show IFA of procyclic and bloodstream T. brucei, respectively, using specific anti-Asf1A and anti-Asf1B antibodies (antibody), DAPI to stain DNA, merged and DIC images. Panel (C) shows IFA using anti-Myc monoclonal antibod... | To start the characterization of the different histone chaperones, we analyzed their cellular distribution by indirect immunofluorescence analysis (IFA). Surprisingly, IFA showed that the protein previously called Asf1A in T. brucei (25,26) is mainly localized in the cytosol, whereas Asf1B is rarely found in the nucleu... | caption | [
"whereas Asf1B is rarely found in the nucleus of procyclic and bloodstream forms (Figure 2A and B, respectively)",
"whereas Asf1B is sporadically cytosolic"
] | [
"whereas Asf1B is mostly found in the nucleus of procyclic and bloodstream forms (Figure 2A and B, respectively)",
"whereas Asf1B is predominantly cytosolic"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010064871_TII_02/figure/2010064871_TII_02_1.png"
],
"tampered": true,
"paper_ids": [
"2010000797"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010190264_TII_02/figure/2010190264_TII_02_2.png | consistency_56 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 3 Mitoprotection preserved calcium cycling activity. Thapsigargin-sensitive sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA)-2a protein levels (A) and activity (B) were reduced in renovascular hypertensive (RVH) pigs, whereas SERCA-2a activity K₀.₅ was decreased (C), but all were improved in RVH+Mitochondrial-tar... | Affinity for calcium was higher than normal (higher SERCA-2a activity K₀.₅), but both were restored in HC-RVH+MTP (Figure 3A through C). PLB activation (p-PLB-S16/total) decreased in HC-RVH+Vehicle, but restored in HC-RVH+MTP (Figure 3D), whereas activation of RYR2 (p-RYR2/Total RYR2) and NCX protein levels were simila... | caption | [
"whereas SERCA-2a activity K₀.₅ was decreased (C)",
"Affinity for calcium was higher than normal (higher SERCA-2a activity K₀."
] | [
"whereas SERCA-2a activity K₀.₅ was elevated (C)",
"Affinity for calcium was lower than normal (higher SERCA-2a activity K₀."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010190264_TII_02/figure/2010190264_TII_02_2.png"
],
"tampered": true,
"paper_ids": [
"2010000806"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010131284_TII_01/figure/2010131284_TII_01_5.png | consistency_57 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 5. Soluble free glycan metabolites in various tissue homogenates and urine from a GLB1 null mouse. Soluble glycans were extracted from a 7-month-old β-galactosidase-deficient mouse and end-labeled with aniline as described in the Methods section. Putative structures are shown over some of the glycan metabolites in... | In order to determine if oligosaccharide metabolites similar to those detected in brain also accumulate in other tissues in the GLB1 null mouse, we screened for soluble glycans in liver, spleen, kidney, and urine samples. We detected the same types of metabolites in all tissues analyzed as well as in urine from the kno... | related_sentences | [
"eluting at just over 47 min"
] | [
"eluting at just over 37 min"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010131284_TII_01/figure/2010131284_TII_01_5.png"
],
"tampered": true,
"paper_ids": [
"2010000860"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041549_TII_02/figure/2010041549_TII_02_0.png | consistency_58 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | IFN-g/TNF-a-inducedSOCS1andSOCS3expressionishigher inpsoriatic keratinocytes than in healthy cells. (a) Cultured keratinocytes were prepared from healthy skin or from biopsies taken from uninvolved psoriatic skin. SOCS1 and SOCS3 mRNA levels were detected by real-time PCR analysis in cultured healthy (Healthy KC, &)(n¼... | To compare SOCS levels in healthy and psoriatic keratinocyte strains, we isolated cells from skin biopsies obtained from psoriatic patients and healthy donors, and left untreated or stimulated with IFN-g plus TNF-a for 3h. We found that SOCS3 and SOCS1mRNA and protein expression was substantially lower in IFN-g/ TNF-a-... | related_sentences | [
"We found that SOCS3 and SOCS1mRNA and protein expression was substantially lower in IFN-g/ TNF-a-activated keratinocytes obtained from psoriatic patients compared with those isolated from healthy donors (Figure 1a, Po0.01 and Po0.05 for SOCS3 and SOCS1"
] | [
"We found that SOCS3 and SOCS1mRNA and protein expression was substantially higher in IFN-g/ TNF-a-activated keratinocytes obtained from psoriatic patients compared with those isolated from healthy donors (Figure 1a, Po0.01 and Po0.05 for SOCS3 and SOCS1"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041549_TII_02/figure/2010041549_TII_02_0.png"
],
"tampered": true,
"paper_ids": [
"2010000890"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010064722_TII_01/figure/2010064722_TII_01_6.png | consistency_59 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 4. RNE associates with RHON1 in a HMW complex. (A) Soluble protein extracts from rhon1TAP or WT were immunoprecipitated using an HA matrix. Samples from stromal extract (L), IP flow through (FT) and the IP eluate (E) were separated in 10% SDS-PAGE and subjected to immunoblot analysis using the antibodies indicat... | To confirm the RNE–RHON1 association by an independent experiment, we investigated Co-IPs of rhon1TAP lines. Using the HA antibody, we could observe a distinct RHON1 signal in lysate, flow through, and eluate of rhon1TAP but not of untagged wild-type lines. Notably, the tagged RHON1 protein shows the same anomaly of mi... | related_sentences | [
"sub-complexes >140 kDa disappeared almost completely and gave rise to a prominent and distinct RHON1TAP-containing complex of 140 kDa (Figure 4C)"
] | [
"sub-complexes >150 kDa disappeared almost completely and gave rise to a prominent and distinct RHON1TAP-containing complex of 150 kDa (Figure 4C)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010064722_TII_01/figure/2010064722_TII_01_6.png"
],
"tampered": true,
"paper_ids": [
"2010000953"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010105083_TII_01/figure/2010105083_TII_01_0.png | consistency_60 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1 (A) Chemical structure of PQDN. (B) Approximately 310 compounds were screened to identify compounds enhancing the activation of CD8 T cells despite weak antigen stimulation. Splenocytes from DUC18 mice were stimulated with 9m antigen in the presence of a compound for 72 hours, and cell proliferation and CD25 e... | RESULTS Identification of a small molecule enhancing CD8 T cell activation even with weak TCR stimulation We screened 310 small molecules from the in-house chemical library of the University of Shizuoka to identify novel compounds that enhance CD8 T cell activation despite weak antigen stimulation. We cultured splenocy... | related_sentences | [
"We also observed that PQDN increased CD25 expression and cell proliferation up to 6 µM in a concentration-dependent manner"
] | [
"We also observed that PQDN increased CD25 expression and cell proliferation up to 3 µM in a concentration-dependent manner"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010105083_TII_01/figure/2010105083_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010000980"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010115737_TII_02/figure/2010115737_TII_02_0.png | consistency_61 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. Hypoxia promotes cell stemness, migration, and invasion of NSCLC. (a) Sphere formation of CSCs sorted from A549 and H838 cells. (b) The protein levels of the markers of cell stemness including NANOG and CD133. (c) The represent images of cell migration under a microscope. The migration rate was quantified. (d... | To explore the biological functions of hypoxia, we evaluated sphere formation of CSCs and metastasis of NSCLC cells. Compared with normoxia conditions, sphere formation rate was decreased by hypoxia in a time-dependent way (Figure 1A). The protein levels of NANOG and CD133 were upregulated in a time-dependent manner (F... | related_sentences | [
"sphere formation rate was decreased by hypoxia in a time-dependent way (Figure 1A)."
] | [
"sphere formation rate was increased by hypoxia in a time-dependent way (Figure 1A)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010115737_TII_02/figure/2010115737_TII_02_0.png"
],
"tampered": true,
"paper_ids": [
"2010001076"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010113229_TII_02/figure/2010113229_TII_02_4.png | consistency_62 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 5. Effect of E-64 treatment on development and quality of porcine parthenotes. (A) Blastocyst formation of porcine parthenotes cultured in the presence of E-64. (B) Total cell number was determined using Hoechst 33342 staining. (C) The number of apoptotic cells was determined by TUNEL assay. Black bar, control gro... | Embryos treated with 1 μM (40.3 ± 4.06%) or 10 μM E-64 (39.2 ± 3.33%) displayed increased blastocyst formation compared with the control group (31.6 ± 3.91%). However, formation of blastocysts at a concentration of 100 μM (3.7 ± 3.04%) was higher than that of the control group (P < 0.01, Fig. 5A). Furthermore, we check... | related_sentences | [
"formation of blastocysts at a concentration of 100 μM (3.7 ± 3.04%) was higher than that of the control group (P < 0.01, Fig. 5A)"
] | [
"formation of blastocysts at a concentration of 100 μM (3.7 ± 3.04%) was lower than that of the control group (P < 0.01, Fig. 5A)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010113229_TII_02/figure/2010113229_TII_02_4.png"
],
"tampered": true,
"paper_ids": [
"2010001154"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010040265_TII_02/figure/2010040265_TII_02_4.png | consistency_63 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. DRAM activates autophagy in fibroblasts, driving mitochondrial dysfunction. (A) OXPHOS immunoblotting. Given the upregulation of BNIP3 (a marker of mitophagy), we also investigated the status of mitochondrial OXPHOS (complexes I–V). Note that DRAM-overexpressing fibroblasts showed significant growths in compo... | As BNIP3 is a marker of mitophagy, we also investigated the status of mitochondrial OXPHOS (complexes I–V). Interestingly, DRAM-overexpressing fibroblasts showed significant reductions in components of complex I, III and IV (Fig. 4A) by immunoblotting, consistent with a mitophagy phenotype. Increased L-lactate and keto... | caption | [
"Note that DRAM-overexpressing fibroblasts showed significant growths in components of OXPHOS complexes I",
"DRAM-overexpressing fibroblasts showed dramatic decreases in L-lactate (> 3-fold) and β-hydroxy-butyrate (~3–5-fold) production"
] | [
"Note that DRAM-overexpressing fibroblasts showed significant reductions in components of OXPHOS complexes I",
"DRAM-overexpressing fibroblasts showed dramatic increases in L-lactate (> 3-fold) and β-hydroxy-butyrate (~3–5-fold) production"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010040265_TII_02/figure/2010040265_TII_02_4.png"
],
"tampered": true,
"paper_ids": [
"2010001182"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010125211_TII_02/figure/2010125211_TII_02_6.png | consistency_64 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 4. Inflammatory and immune profile in adult and elderly burned patients. (A–F) Adults show a decrease in inflammatory mediators over time, while elderly demonstrate the opposite picture; IL-6, TNF, IL-15, MCP-1 and GM–CSF all increased over the time course after burn indicating a hypo-inflammation followed by hype... | We hypothesized that elderly have an altered immune and inflammatory response. We first determined a panel of 6 cytokines and chemokines over time. Based on pilot studies we found that elderly have a distinct profile with an early hyper-inflammation followed by a hyper-inflammation after 2 weeks post-burn (data not sho... | caption | [
"Elderly had significantly increased numbers of CD14+/HLA-DR+ monocytes (G).",
"Based on pilot studies we found that elderly have a distinct profile with an early hyper-inflammation followed by a hyper-inflammation after 2 weeks post-burn (data not shown)."
] | [
"Elderly had significantly reduced numbers of CD14+/HLA-DR+ monocytes (G).",
"Based on pilot studies we found that elderly have a distinct profile with an early hypo-inflammation followed by a hyper-inflammation after 2 weeks post-burn (data not shown)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010125211_TII_02/figure/2010125211_TII_02_6.png"
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"tampered": true,
"paper_ids": [
"2010001200"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010035189_TII_01/figure/2010035189_TII_01_4.png | consistency_65 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2 Cardiometabolic deaths attributable to dietary and metabolic risk factors in the Middle East and North Africa among (A) men, (B) women, (C) total adult population (2010). Other cardiovascular diseases (CVDs) include hypertensive heart disease, aortic aneurysm, rheumatic heart disease, inflammatory heart diseas... | CMD mortality attributable to metabolic risk factors by countryNon-optimal SBP (>115 mm Hg) was the leading metabolic risk for CMD mortality in the region accounting for 48% of CMD deaths (436 190 deaths, 95% UI 422 098 to 651 182) (figure 2). Non-optimal BMI (>23 Kg/m2 ) and fasting plasma glucose (>5.3 mmol/L) caused... | related_sentences | [
"CMD mortality attributable to metabolic risk factors by countryNon-optimal SBP (>115 mm Hg) was the leading metabolic risk for CMD mortality in the region accounting for 48% of CMD deaths (436 190 deaths, 95% UI 422 098 to 651 182) (figure 2)"
] | [
"CMD mortality attributable to metabolic risk factors by countryNon-optimal SBP (>115 mm Hg) was the leading metabolic risk for CMD mortality in the region accounting for 48% of CMD deaths (436 190 deaths, 95% UI 422 098 to 451 182) (figure 2)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010035189_TII_01/figure/2010035189_TII_01_4.png"
],
"tampered": true,
"paper_ids": [
"2010001264"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010040066_TII_02/figure/2010040066_TII_02_2.png | consistency_66 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | FIGURE 3 Changes in the activation of epidermal growth factor receptor (EGFR), ERK, and Akt with (+) or without (-) collagen type I (ColI) by gefitinib. A, EGFR, ERK, and Akt phosphorylation (p-) and total protein (t-) in PC-9 cells cultured with or without Col I. B, Quantitative analysis of EGFR, ERK, and Akt phosphor... | Both the MAPK and PI3K pathways are active in primary and acquired resistance to gefitinib. Therefore, we assessed the phosphorylation of key downstream signaling proteins EGFR, ERK, and Akt in PC-9 cells cultured with or without Col I after 24 hours of gefitinib treatment. Gefitinib treatment induced the stimulation o... | related_sentences | [
"Gefitinib treatment induced the stimulation of p-EGFR, p-ERK, and p-Akt expression (Figure 3)"
] | [
"Gefitinib treatment induced the suppression of p-EGFR, p-ERK, and p-Akt expression (Figure 3)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010040066_TII_02/figure/2010040066_TII_02_2.png"
],
"tampered": true,
"paper_ids": [
"2010001589"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010040887_TII_02/figure/2010040887_TII_02_3.png | consistency_67 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4 Levels of inflammatory factors in different groups. (a-e) IgA, IL-4, IL-8, IL-17, TNF-α expression levels of different groups. Notes: Compared with the control group, *P < 0.05, **P < 0.01; Compared with the model group, ##P < 0.01. | PCs Attenuated the Inflammatory Reaction of HSP Serum-Induced CellsHSP serum remarkably enhanced the levels of IgA, IL-4, IL-8, IL-17 and TNF-α of HUVECs (P < 0.05) (Figure 4). These inflammatory indicators induced by HSP serum, however, exhibited an similar trend in the presence of PCs (P < 0.05); that was, PCs promin... | related_sentences | [
"PCs Attenuated the Inflammatory Reaction of HSP Serum-Induced CellsHSP serum remarkably enhanced the levels of IgA",
"exhibited an similar trend in the presence of PCs",
"huge significant difference was found among the differentconcentration PCs groups (P > 0.05)."
] | [
"PCs Attenuated the Inflammatory Reaction of HSP Serum-Induced CellsHSP serum remarkably enhanced the levels of IgA",
"exhibited an opposite trend in the presence of PCs",
"little significant difference was found among the differentconcentration PCs groups (P > 0.05)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010040887_TII_02/figure/2010040887_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010001640"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010127706_TII_01/figure/2010127706_TII_01_1.png | consistency_68 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2. Expression Process of CD36 on Erythroid Cells of Different Origins (A–C) Representative flow cytometry profiles showing expression of CD36 on GPA+ cells derived from hCB-CD34+ HSPCs (A), H1/AGM-S3 co-culture (B), and day-10 + 5 and 10 + 9 suspension cultures (C). | The surface markers of adult HSPC-derived erythroblasts have been well studied (Chen et al., 2009). Our flow cytometry data were consistent with previous reports that as human CD34+ HSPCs differentiate toward erythroblasts, the expression of CD34 disappeared exclusively before gaining expression of erythroid lineage ma... | related_sentences | [
"The percentage and absolute number of G+36low/+ cells increased after 3 days (day 10 + 3) and gradually decreased after an additional 4 days (day 10 + 9) (Figures 2C–2E)."
] | [
"The percentage and absolute number of G+36low/+ cells increased after 5 days (day 10 + 5) and gradually decreased after an additional 4 days (day 10 + 9) (Figures 2C–2E)."
] | {
"all_images_paths": [
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"tampered": true,
"paper_ids": [
"2010001645"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010049169_TII_02/figure/2010049169_TII_02_3.png | consistency_69 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4 Modular analysis of PPI network (A) Module 1 contains 23 genes. (B) Module 3 contains 17 genes. (C) GO and KEGG analysis of genes in Module 1. (D) GO and KEGG analysis of genes in Module 3. | Since the PPI network constructed by us was relatively small, the MCODE plugin was used to calculate the modules with an MCODE score of >5 and identify the most important modules. Finally, a total of 6 modules (for detailed results, see Supplementary Excel S1: Sheet4 and Figure S1) was identified, out of which, two (mo... | related_sentences | [
"Since the PPI network constructed by us was relatively small,",
"There were 23 genes in module 1 (12 downregulated genes and 11 downregulated genes),"
] | [
"Since the PPI network constructed by us was relatively large,",
"There were 23 genes in module 1 (12 upregulated genes and 11 downregulated genes),"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010049169_TII_02/figure/2010049169_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010001646"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010049551_TII_02/figure/2010049551_TII_02_3.png | consistency_70 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. Validation of microarray data from siWT1 and shWT1 knockdown experiments by Q-RT-PCR. All Q-RT-PCR data are displayed relative to a non-silencing si- or shRNA control that is set at 1. Data represent the mean of triplicates, and the standard deviations are indicated for each experiment. PCR reactions were don... | To gain more insight into the function of mutant WT1Wilms3 and WT1Wilms2 proteins, we performed siRNA (siWT1) knockdown analyses. First, we tested different WT1-specific siRNA oligonucleotides and found that a combination of two siRNAs directed against sequences in exon 6 and the 3′ UTR of WT1 achieved a very efficient... | related_sentences | [
"and a improvement of WT1Wilms3 expression by 82% was measured",
"7-fold downregulation of PODXL1"
] | [
"and a reduction of WT1Wilms3 expression by 82% was measured",
"7-fold upregulation of PODXL1"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010049551_TII_02/figure/2010049551_TII_02_3.png"
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"tampered": true,
"paper_ids": [
"2010001660"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041482_TII_02/figure/2010041482_TII_02_6.png | consistency_71 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 7 Beclin-1 silencing reduces RGC-5 viability following SD. (a) Effectiveness of Beclin-1 silencing and effect on LC3. Transfection of specific Beclin-1-siRNA or scramble non-targeting (NT) sequence at final concentration of 25 nM was performed, 48 h before SD, in 96-well plate with Lipofectamine 2000 according t... | Beclin-1 silencing reduces RGC-5 viability under starvation. To investigate the effects of Beclin-1 reduction on RGC survival, cells were transfected with rat Beclin-1-siRNA 48 h before SD. Gene silencing reduced Beclin-1 expression by 95% compared with starved scrambletransfected cells as shown by western blotting ana... | related_sentences | [
"Beclin-1 silencing significantly worsened the improvement of RGC-5 viability"
] | [
"Beclin-1 silencing significantly worsened the reduction of RGC-5 viability"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041482_TII_02/figure/2010041482_TII_02_6.png"
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"tampered": true,
"paper_ids": [
"2010001678"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010057590_TII_01/figure/2010057590_TII_01_0.png | consistency_72 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Effects of immediate treatment with eplerenone (Eple) and spironolactone (Spiro) on survival and hemodynamics in mice 3 days after myocardial infarction (MI). (A) Kaplan-Meier survival curve analyzed by log-rank test (*P < 0.05). (B) Hemodynamic measurements including left ventricular filling pressure (LVEDP)... | Kaplan-Meier analysis demonstrated significantly improved survival at 7 days post-infarction exclusively in eplerenone-treated mice (Figure 1A). Infarct sizes were comparable across all experimental groups (Table 1). At 7 days post-MI, placebo-treated mice developed: (1) elevated left ventricular filling pressure (LVED... | caption | [
"Effects of immediate treatment with eplerenone (Eple) and spironolactone (Spiro) on survival and hemodynamics in mice 3 days after myocardial infarction (MI)"
] | [
"Effects of immediate treatment with eplerenone (Eple) and spironolactone (Spiro) on survival and hemodynamics in mice 7 days after myocardial infarction (MI)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010057590_TII_01/figure/2010057590_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010001695"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010129304_TII_02/figure/2010129304_TII_02_2.png | consistency_73 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 1. DLA-M decreases body weight and improves insulin resistance in HFD C57BL/6J mice. NCD and HFD (60% kcal fat) C57BL/6J mice were treated daily with water or 1 g/kg/day DLA-M by intragastric gavage for 10 weeks (n = 6–15). Effects of DLA-M treatment on the body weight gain and the calculated AUC (a), serum TG and... | Two mouse models of obesity—10-week-old male C57BL/6J and CD-1 mice—were fed a normal chow diet (NCD) or a high-fat diet (HFD) for 10 and 5 weeks, respectively. In agreement with previous work using an obese rat model (Xu et al., 2016), DLA-M prevented body weight loss in both animal models, but did not cause a signifi... | related_sentences | [
"DLA-M prevented body weight loss in both animal models"
] | [
"DLA-M prevented body weight gain in both animal models"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010129304_TII_02/figure/2010129304_TII_02_2.png"
],
"tampered": true,
"paper_ids": [
"2010001701"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010014696_TII_02/figure/2010014696_TII_02_2.png | consistency_74 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Calcineurin removes activating phosphorylations from Hcm1. (A) Strains expressing the indicated Hcm1 proteins were treated with CaCl2 for 10 min, and phosphorylation was assayed by Phos-tag Western blot. Note that the top band in the 12C sample is also present in the 15A sample, suggesting that it is the result of Cdk1... | Under these gel conditions, the phosphorylation status of a panel of Hcm1 mutants with different numbers of Cdk1 phosphosites is clearly distinguishable (Figure 2, A and C). In addition, we found that within 10 min of direct CN activation by the addition of CaCl2 to the growth medium, Hcm1 was mildly dephosphorylated (... | related_sentences | [
"Hcm1 was mildly dephosphorylated (Figure 2D)."
] | [
"Hcm1 was dramatically dephosphorylated (Figure 2D)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010014696_TII_02/figure/2010014696_TII_02_2.png"
],
"tampered": true,
"paper_ids": [
"2010001712"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010073211_TII_01/figure/2010073211_TII_01_3.png | consistency_75 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 4. Effect of pH on the release of methylprednisolone (MP) from the BSA633-MP nanoconjugate. The nanoconjugates were incubated in (A) PBS at pH 7.4 and (B) acetate buffer at pH 4.0 for 48 h at 37°C. After incubation, samples were eluted in a column with Sephadex G-100 gel. An amount of 0.5 ml of each fraction was... | Release profile of BSA633‑MP. The effects of neutral pH and relatively acidic pH on the release profile of BSA633‑MP conjugate were evaluated. As shown in Fig. 4A, we clearly see that under pH 7.4, almost nothing was released from the BSA633-MP conjugate. However, under pH 4.0, most MP molecules were released, a small ... | related_sentences | [
"0 ~28% of MP drug was released after 48 h."
] | [
"0 ~72% of MP drug was released after 48 h."
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010073211_TII_01/figure/2010073211_TII_01_3.png"
],
"tampered": true,
"paper_ids": [
"2010001836"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010035913_TII_02/figure/2010035913_TII_02_3.png | consistency_76 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 3 Percentage of patients achieving glycaemic control according to HbA1c intervals. HbA1c, glycated haemoglobin; T2DM, type 2 diabetes mellitus | Finally, the analysis of the evolution of the attained glycaemic control according to different HbA1c intervals also showed that there were many remarkable changes among years in any case (figure 3). Of note, the group of patients who were less likely to achieve the corresponding glycaemic target included those younger... | related_sentences | [
"Finally, the analysis of the evolution of the attained glycaemic control according to different HbA1c intervals also showed that there were many remarkable changes among years in any case (figure 3)"
] | [
"Finally, the analysis of the evolution of the attained glycaemic control according to different HbA1c intervals also showed that there were no remarkable changes among years in any case (figure 3)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010035913_TII_02/figure/2010035913_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010001838"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010123552_TII_01/figure/2010123552_TII_01_0.png | consistency_77 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 1. Hepatic insulin receptor substrate and PI3K proteins expression in ApoE knock-in mice. (A) Western blot analysis of insulin receptor substrate-1 (IRS1), PI3K/p85 and PI3K/p110 levels in the liver of ApoE3 and ApoE4 mice at 12 and 72 weeks of age. β-actin was immunoblotted to ensure similar gel loading of the st... | At 72 weeks, insulin receptor substrate 1 (IRS1) expression does not differ between fasting ApoE3 and ApoE4 mice (Fig. 1A). At 12 weeks, however, IRS1 expression is non-detectable in the fasting ApoE4 KI mice. We then examined the expression of the catalytic subunit (p110) and the regulatory subunit (p85) of phosphatid... | related_sentences | [
"At 72 weeks, insulin",
"At 12 weeks, however"
] | [
"At 12 weeks, insulin",
"At 72 weeks, however"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010123552_TII_01/figure/2010123552_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010001866"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010127336_TII_02/figure/2010127336_TII_02_0.png | consistency_78 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1: MRTFA KO mice have smaller body weight, reduced bone mass with shorter femurs and tibiae. WT (n = 7) and MRTFA KO (n = 7) female mice (24 weeks old) were euthanized and then weighed. The image of a matched pair of WT and MRTFA KO mice is shown in (A). The femurs and tibiae of the mice were then dissected (ima... | Six-week-old MRTFA KO mice are taller and weigh less than WT littermates (Figure 1A and B and Supplementary Figure 1). This observation suggested that there might be a defect in skeletal development. To investigate a possible role of MRTFA in bone formation, lengths of the femurs and tibiae were measured with calipers.... | related_sentences | [
"Six-week-old MRTFA KO mice are taller and weigh less than WT littermates (Figure 1A and B and Supplementary Figure 1).",
"μCT of the mid-diaphyseal region of femurs showed that cortical thickness of femurs from MRTFA KO mice is significantly thicker than WT controls (Figure 1F, G)",
"Trabecular bone volume fra... | [
"Six-week-old MRTFA KO mice are shorter and weigh less than WT littermates (Figure 1A and B and Supplementary Figure 1).",
"μCT of the mid-diaphyseal region of femurs showed that cortical thickness of femurs from MRTFA KO mice is significantly thinner than WT controls (Figure 1F, G)",
"Trabecular bone volume fr... | {
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"paper_ids": [
"2010001884"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010014663_TII_02/figure/2010014663_TII_02_3.png | consistency_79 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | The c-Myb protein level is critical for GSK3β-dependent cell survival. (A) Jurkat, K562, and RPMI 8226 cells were treated with or without 5 or 10 μM SB216763 for 8 h, and cell lysates were analyzed by immunoblotting. (B) RPMI 8226, K562, and Jurkat cells were infected with lentivirus expressing GSK3β shRNA or a nonspec... | We next tested the effect of GSK3β inactivation on the c-Myb and LEF-1 proteins. Of importance, in all leukemia cells examined, the levels of c-Myb were increased upon SB216763 or LiCl treatment, whereas the levels of LEF-1 did not show significant similarity (Figure 4A and Supplemental Figure S3). RNAi-mediated deplet... | related_sentences | [
"the levels of c-Myb were increased upon SB216763 or LiCl treatment",
"whereas the levels of LEF-1 did not show significant similarity (Figure 4A and Supplemental Figure S3)"
] | [
"the levels of c-Myb were reduced upon SB216763 or LiCl treatment",
"whereas the levels of LEF-1 did not show significant differences (Figure 4A and Supplemental Figure S3)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010014663_TII_02/figure/2010014663_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010001886"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010124577_TII_01/figure/2010124577_TII_01_0.png | consistency_80 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. hMSC-to-MF Activation Reduces Clonogenicity and Lineage Differentiation Potential (A and B) hMSCs were cultured with and without TGF-β1 (2 ng/ml) for 4 days to assess MF activation by staining for α-SMA (red) and stress fibers (F-actin, green), for 10 days to assess CFU-F formation, and 14 days to assess adip... | MF Activation Results in Reduced Clonogenicity and Differentiation Potential of hMSCsIndependently of MSC origin, MF activation occurs spontaneously in standard cell culture on rigid tissue culture plastic in serum-containing media. Cultured hMSCs derived from adipose tissue, umbilical cord perivasculature, and bone ma... | related_sentences | [
"4% (26 kPa) and 10.3% ± 3."
] | [
"4% (26 kPa) and 5.7% ± 3."
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010124577_TII_01/figure/2010124577_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010001903"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010127644_TII_02/figure/2010127644_TII_02_4.png | consistency_81 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 3. Silica-coated ZnO NPs exhibit antimicrobial activity comparable to uncoated ZnO NPs. The growth of *E. coli* was inhibited by both uncoated and silica-coated ZnO NPs after (A) 3 h and (B) 21 h of incubation. Similarly, the growth of *S. aureus* was significantly inhibited by both types of NPs after (C) 3 h an... | After confirming the presence of silica coating on ZnO nanoparticles (NPs), we assessed how this modification affects their antimicrobial properties. As shown in Figure 3, the silica coating retained—and in the case of *S. aureus*, even slightly enhanced—the antimicrobial effect upon both short (3 h) and long (21 h) ex... | related_sentences | [
"ZnO NPs demonstrated weaker antimicrobial activity than SiO₂ NPs (Figure 3A, B)"
] | [
"ZnO NPs demonstrated stronger antimicrobial activity than SiO₂ NPs (Figure 3A, B)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010127644_TII_02/figure/2010127644_TII_02_4.png"
],
"tampered": true,
"paper_ids": [
"2010001978"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010013696_TII_01/figure/2010013696_TII_01_8.png | consistency_82 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | SNV binding to integrin PSI domain recapitulates physiological activation of αIIbβ3. (A, B) Model of SNV-induced extended conformation associated with a high-affinity state with separated α and β transmembrane and cytoplasmic domains, which allows the ligand-mimetic monoclonal anti-αIIbβ3 antibody PAC1 to bind to CHO-A... | In the C3 cells, the αIIb 968 tryptophan (W) and the 693 isoleucine (I) residues were replaced with cysteines to prevent the separation of the cytoplasmic domains through constitutive disulfide bond formation (Luo et al., 2004) (Figure 9). Exposure of CHO-A24 and CHO-C3 cells to SNV for 5 min produced a twofold increas... | related_sentences | [
"Exposure of CHO-A24 and CHO-C3 cells to SNV for 5 min produced a twofold increase in PAC1 binding to A24 cells compared with the resting state (Figure 9A)"
] | [
"Exposure of CHO-A24 and CHO-C3 cells to SNV for 5 min produced a threefold increase in PAC1 binding to A24 cells compared with the resting state (Figure 9A)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010013696_TII_01/figure/2010013696_TII_01_8.png"
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"tampered": true,
"paper_ids": [
"2010002000"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010074157_TII_02/figure/2010074157_TII_02_3.png | consistency_83 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. DLS inhibits chemokine-mediated signaling in CCR5-transfected 3T3 cell lines. Approximately 200,000 3T3.T4.CCR5 cells were grown overnight per well in a 6-well plate. On the following day, the media was replaced with 2 ml of serum-free medium. After 2–3 h, DLS (20 μM) or the CCR5-specific antagonist, TAK779 (... | 3T3.T4.CCR5 cells were grown overnight and then pretreated with DLS (20 μM) or the CCR5-specific antagonist, TAK779 (2 μM) for 30 minutes at 37 °C, after which 10 nM of MIP-1β or RANTES were added to cultures. The cells were harvested in RIPA after washing with cold PBS at the indicated times. The results (Figure 4) re... | caption | [
"The results reveal that DLS partially allows RANTES-induced ERK activation but surprisingly does not block MIP-1β-induced ERK activation in 3T3.T4.CCR5 cells",
"MIP-1β-induced ERK activation was not affected by DLS using this cell line"
] | [
"The results reveal that DLS partially blocks RANTES-induced ERK activation but surprisingly does not block MIP-1β-induced ERK activation in 3T3.T4.CCR5 cells",
"MIP-1β-induced ERK activation was not influenced by DLS using this cell line"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002043"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010040108_TII_02/figure/2010040108_TII_02_0.png | consistency_84 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | FIGURE 1 Dickkopf-1 (DKK1) inhibition reverses suppressive tumor immune microenvironment of a syngeneic gastric cancer (GC) model. (A) Schematic of DKK1 inhibitor (WAY-262611) treatment schedule in GC subcutaneous model. (B) Representative images of tumors and (C) tumor volumes of mouse forestomach carcinoma (MFC)-chal... | To investigate whether DKK1 inhibition showed antitumor efficacy in GC models, we established an MFC-challenged GC syngeneic immunocompetent mouse model and a T cell-deficient mouse model, followed by treatment with DKK1 inhibitor (WAY-262611) or DMSO (control group for WAY-262611) as indicated (Figures 1A and S1A). An... | related_sentences | [
"An interesting finding was that the tumor size and tumor volume increased significantly in GC immunocompetent mice (Figure 1B,C)"
] | [
"An interesting finding was that the tumor size and tumor volume decreased significantly in GC immunocompetent mice (Figure 1B,C)"
] | {
"all_images_paths": [
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"tampered": true,
"paper_ids": [
"2010002073"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010049515_TII_02/figure/2010049515_TII_02_2.png | consistency_85 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 3. p53 expression at both the protein and mRNA level. (A) Western blot of p53 protein in SDHx variant-positive CS/CSL (patient ID—SDHx variant: 829LL-S163P, 1965ML-S163P, 2094GR-H50R, 2549MP-G12S, 2854PS-S163P, 2894KP-H50R) and normal control groups. Upper panel shows the protein profile under normal culture con... | Exposure of cells to high levels of ROS leads to oxidative stress, and should induce a p53-mediated response including apoptosis, whereas we observed the opposite in our cases. Therefore, we decided to investigate if p53 is somehow modified in our patient samples in order to escape the expected apoptotic regulation. We... | related_sentences | [
"Cells treated with proteasome inhibitor MG132 preserved the loss of the p53 protein phenomenon in SDHx variant-positive cells (Fig. 3A and B, lower panels)"
] | [
"Cells treated with proteasome inhibitor MG132 abolished the loss of the p53 protein phenomenon in SDHx variant-positive cells (Fig. 3A and B, lower panels)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010049515_TII_02/figure/2010049515_TII_02_2.png"
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"paper_ids": [
"2010002143"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010074872_TII_02/figure/2010074872_TII_02_8.png | consistency_86 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 9. Alizarin-red assay to bone matrix mineralization. (A) Staining (Scale bar: 100 μm), and (B) Quantitative calcium level deposition. Data are expressed as the mean ± S.D (n = 3). *p < 0.05, **p < 0.001. | Extracellular matrix mineralization and quantitative calcium-level deposition were determined at 14 days postculture by Alizarin red staining. As shown in Figure 9A, in the presence of His‑βCD‑PH and HP‑βCD‑PH, matrix mineralization was decreased clearly compared with the control. Free PH in DMSO at a concentration of ... | related_sentences | [
"matrix mineralization was decreased clearly compared with the control",
"calcium-level deposition was significantly decreased when hASCs were cultured with His‑βCD‑PH and HP‑βCD‑PH at 50 μM concentration compared with the control"
] | [
"matrix mineralization was increased clearly compared with the control",
"calcium-level deposition was significantly increased when hASCs were cultured with His‑βCD‑PH and HP‑βCD‑PH at 50 μM concentration compared with the control"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010074872_TII_02/figure/2010074872_TII_02_8.png"
],
"tampered": true,
"paper_ids": [
"2010002283"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010119081_TII_02/figure/2010119081_TII_02_2.png | consistency_87 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 3. Effects of curcumin on serum TGF-β1 and lung TGF-β1 and CTGF expression in irradiated rats. (A) Serum concentrations (n = 5–6 per group) of TGF-β1 in control (CTL), radiation (RT), radiation＋curcumin (RT＋Cur), and curcumin (Cur) rats. (B) Western blot showing TGF-β1 and CTGF in lung from each group. (C) Quantif... | To evaluate whether curcumin could attenuate radiation-induced collagen synthesis in rat lungs, we assessed serum TGF-β1 levels by ELISA and TGF-β1 and CTGF expression levels with western blots (Fig. 3). Serum TGF-β1 levels from irradiated rat lungs were significantly decreased compared to irradiated curcumin-treated r... | related_sentences | [
"Serum TGF-β1 levels from irradiated rat lungs were significantly decreased compared to irradiated curcumin-treated rats (Fig. 3A)"
] | [
"Serum TGF-β1 levels from irradiated rat lungs were significantly increased compared to irradiated curcumin-treated rats (Fig. 3A)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010119081_TII_02/figure/2010119081_TII_02_2.png"
],
"tampered": true,
"paper_ids": [
"2010002308"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010079947_TII_01/figure/2010079947_TII_01_0.png | consistency_88 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Effects of NFKBIE knockdown on the expression levels of SLC19A1 and ABC transporters. Quantitative gene expressions of NFKBIE (A), SLC19A1 (B), ABCC1 (C), ABCC5 (D), and ABCG2 (E) genes in control (gray) and NFKBIE knockdown (black) MH7A treated with or without 0.01, 0.1, 1, 5, and 10 mM methotrexate (MTX) ap... | To investigate the effects of NFKBIE knockdown on the expressions of drug membrane transporters, we confirmed expression by qRT-PCR. The NFKBIE expression level in the NFKBIE knockdown group was almost 18–20% of the control expression level under many conditions (Figure 1A). NFKBIE knockdown could reduce the SLC19A1 ex... | related_sentences | [
"The NFKBIE expression level in the NFKBIE knockdown group was almost 18–20% of the control expression level under many conditions (Figure 1A)."
] | [
"The NFKBIE expression level in the NFKBIE knockdown group was almost 12–20% of the control expression level under many conditions (Figure 1A)."
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010079947_TII_01/figure/2010079947_TII_01_0.png"
],
"tampered": true,
"paper_ids": [
"2010002328"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010057714_TII_02/figure/2010057714_TII_02_3.png | consistency_89 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. Direct vascular effects of particles in rat aortic rings in vitro. Effect of diesel exhaust particles (filled circle), carbon nanoparticles (u) (both 100 μg/mL), or vehicle (open circle) (Krebs buffer) on (A) phenylephrine contraction in mN, (B) phenylephrine contraction as a percentage of maximum contraction... | In vitro exposure of rat aortic rings to diesel exhaust particles produced a small decrease in the maximum contractile response to phenylephrine (P=0.03, unpaired t-test; Figure 4A), without affecting the sensitivity to phenylephrine. Pure carbon nanoparticles did not significantly alter responses to phenylephrine and,... | related_sentences | [
"In vitro exposure of rat aortic rings to diesel exhaust particles produced a small decrease in the maximum contractile response to phenylephrine (P=0.03, unpaired t-test; Figure 4A)",
"vasorelaxation to acetylcholine was induced following exposure to diesel exhaust particles (P<0.001; Figure 4C)"
] | [
"In vitro exposure of rat aortic rings to diesel exhaust particles produced a small increase in the maximum contractile response to phenylephrine (P=0.03, unpaired t-test; Figure 4A)",
"vasorelaxation to acetylcholine was inhibited following exposure to diesel exhaust particles (P<0.001; Figure 4C)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010057714_TII_02/figure/2010057714_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010002366"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010013350_TII_01/figure/2010013350_TII_01_2.png | consistency_90 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Defect of fertilization in Pmis2−/− mice and transgenic rescue. (A) Pmis2+/− males and Pmis2−/− females delivered normal numbers of pups when mated with WT mice, whereas the combination of WT females with Pmis2−/− males produced no pups. (B) The defect was at the fertilization level, because no fertilized eggs were rec... | Pups were obtained from Pmis2+/− males and Pmis2−/− females, whereas Pmis2−/− male mice sired no pups in spite of their normal mating behavior (Figure 3A). Eggs were collected from the oviducts after examining for the formation of a vaginal plug, and the fertilization rate was examined. We could obtain no fertilized eg... | related_sentences | [
"whereas almost 0% of the eggs were fertilized in the females mated with Pmis2+/− males (Figure 3B)"
] | [
"whereas almost 100% of the eggs were fertilized in the females mated with Pmis2+/− males (Figure 3B)"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010013350_TII_01/figure/2010013350_TII_01_2.png"
],
"tampered": true,
"paper_ids": [
"2010002370"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010027154_TII_01/figure/2010027154_TII_01_2.png | consistency_91 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 3. a) Schematic representation of different functionalization approaches of SWCNTs with 2_2 and results after three hot filtration steps. b) TGA trace of the reaction outcome (rt to 1000°C, 10°Cmin^-1 under air) for the degree of functionalization (black: pristine SWCNTs, blue: Rev-MINT, red: Irrev-MINT and gree... | Having macrocycles 1_2 and 2_2 as well as efficient conditions for disulfide exchange in hand, we tested our key hypothesis that SWCNTs could act as convex templates during the reversible covalent opening and closing of the concave rings (Figure 3 a, top). The collected solids werewashed multiple times by suspending in... | related_sentences | [
"all samples obtained by the three different experimental approaches show a significant weight loss in the TGA trace between 300 and 400°C (Figure 3 b)",
"we found relatively similar Δm/DoF values for the Rev-MINT-1_2 (33±2%/0.56±0.06%) and Rev-MINT-2_2 (45±3%/0.57±0.07%) samples"
] | [
"all samples obtained by the three different experimental approaches show a significant weight loss in the TGA trace between 300 and 580°C (Figure 3 b)",
"we found relatively similar Δm/DoF values for the Rev-MINT-1_2 (33±2%/0.56±0.06%) and Rev-MINT-2_2 (35±3%/0.57±0.07%) samples"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010027154_TII_01/figure/2010027154_TII_01_2.png"
],
"tampered": true,
"paper_ids": [
"2010002376"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010011621_TII_02/figure/2010011621_TII_02_3.png | consistency_92 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Increased TCR–CD3 recycling is revealed in hypertonic medium. (A) Uptake of Alexa647-labeled transferrin by Jurkat T cell lines expressing SLAP-GFP or control (GFP) in the presence or absence of hypertonic medium, as assessed by FACS. (B) Expression of CD3ε on Jurkat T cell lines expressing SLAP-GFP or control (GFP) in... | To validate the use of hypertonic medium to inhibit TCR–CD3 internalization, we first analyzed the uptake of fluorescently labeled transferrin by the transferrin receptor, a process that requires clathrin-mediated endocytosis (Mellman, 1996; Schmid, 1997). Because DP thymocytes do not express the transferrin receptor, ... | related_sentences | [
"we were able to detect downregulation of CD3ε surface expression over the time course of the experiment in the control cell line",
"Both WT and SLAP−/− DP thymocytes downregulate CD3ε on the cell surface over the course of the assay (Figure 4C)",
"the increase in CD3ε expression was markedly higher than the in... | [
"we were able to detect upregulation of CD3ε surface expression over the time course of the experiment in the control cell line",
"Both WT and SLAP−/− DP thymocytes upregulate CD3ε on the cell surface over the course of the assay (Figure 4C)",
"the increase in CD3ε expression was markedly lower than the increas... | {
"all_images_paths": [
"text_image_inconsistency/trend/2010011621_TII_02/figure/2010011621_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010002377"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010018540_TII_01/figure/2010018540_TII_01_3.png | consistency_93 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fluorogram of HDL apoproteins isolated from rough- and smooth-endoplasmic reticulum fractions. Young chickens were administered t-[aH]leucine and, after 10 min, the livers were removed, fractionated into RER and SER fractions, and the HDL contained within these fractions was isolated by centrifugal flotation and immuno... | There was a small amount of radioactivity in the high molecular weight range, which could be due to aggregation of protein, but there was no evidence of the presence of radioactive proteins of lower molecular size than apoprotein AI (Fig. 4, lanes 3 and 4). By contrast, the contents of the RER and the SER cell fraction... | caption | [
"Lanes 2 and 4 represent nascent HDL apoproteins obtained by immunoprecipitation from the contents of the RER and the SER fractions from 2 g of liver",
"Lanes 1 and 5 represent nascent HDL obtained by flotation from the contents of the RER and SFR fractions from 56 g of liver",
"Lane 1 shows the apoprotein patt... | [
"Lanes 3 and 4 represent nascent HDL apoproteins obtained by immunoprecipitation from the contents of the RER and the SER fractions from 2 g of liver",
"Lanes 1 and 2 represent nascent HDL obtained by flotation from the contents of the RER and SFR fractions from 26 g of liver",
"Lane 5 shows the apoprotein patt... | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010018540_TII_01/figure/2010018540_TII_01_3.png"
],
"tampered": true,
"paper_ids": [
"2010002382"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010019350_TII_02/figure/2010019350_TII_02_5.png | consistency_94 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Cell culture experiments analysing the effects of reggie-1 on Wg and Hh secretion. (A) Effects of overexpression of reggie-1 on Wg secretion measured by Western blots. Serum albumin is shown as the loading control for the medium samples. (B) Effects of overexpression of reggie-1 or a reggie dominant-negative construct ... | We found a dramatically lower uptake of Wg by DsRed cells when Wg was provided by the reggie-1-overexpressing cells (Figure 5D and E). To prove that this intracellular Wg staining resulted from endocytosis, we performed pulse–chase assays with fluorescent dextran beads and found that Wg provided by reggie-1-expressing ... | related_sentences | [
"We found a dramatically lower uptake of Wg by DsRed cells when Wg was provided by the reggie-1-overexpressing cells (Figure 5D and E)",
"Wg obtained from control-transfected cells was strongly endocytosed by the co-cultured cells (Figure 5G)"
] | [
"We found a dramatically higher uptake of Wg by DsRed cells when Wg was provided by the reggie-1-overexpressing cells (Figure 5D and E)",
"Wg obtained from control-transfected cells was poorly endocytosed by the co-cultured cells (Figure 5G)"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010019350_TII_02/figure/2010019350_TII_02_5.png"
],
"tampered": true,
"paper_ids": [
"2010002384"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010028694_TII_02/figure/2010028694_TII_02_8.png | consistency_95 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | (A) In vivo antitumor activity of PSSN10 and various DOX formulations in a syngeneic murine breast cancer model (4T1.2). Three injections were administered on d 0, 3 and 6. **P<0.01. (B) Kaplan-Meier survival of 4T1.2 tumor-bearing mice after various treatments. (C) Histological analyses of H&E stained sections of ... | Figure 5A shows the in vivo therapeutic effects of PSSN10 and DOX/PSSN10 with free DOX and DOXIL (a clinical formulation of liposomal DOX) as controls (5 mg DOX/kg). The PSSN10 carrier alone showed a significant effect in inhibiting tumor growth, comparable to those of DOX and DOXIL. This is in contrast to the in vit... | related_sentences | [
"The PSSN10 carrier alone showed a significant effect in inhibiting tumor growth,",
"DOX formulated in PSSN10 micelles showed inhibited antitumor activity that was significantly higher than that of DOXIL"
] | [
"The PSSN10 carrier alone showed a modest effect in inhibiting tumor growth,",
"DOX formulated in PSSN10 micelles showed enhanced antitumor activity that was significantly higher than that of DOXIL"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010028694_TII_02/figure/2010028694_TII_02_8.png"
],
"tampered": true,
"paper_ids": [
"2010002385"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041575_TII_02/figure/2010041575_TII_02_3.png | consistency_96 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Cannabinoids induce AMPK-dependent GAPDH nuclear translocation. Representative confocal images of GAPDH translocation in Panc1 cell nuclei after 12h treatment with 200mM GW or ACPA in the absence or presence of a pretreatment for 1h with 20mM NAC or 20mM C.C. Values are the means of three independent experiments (±S.D.... | we analysed the cellular distribution of GAPDH after the treatment with GW or ACPA. Figure 4 shows the confocal images where GAPDH appear to be translocated into the nucleus of the cells after 12-h cannabinoid treatments. This effect was stimulated by NAC or CC, indicating its dependence on ROS and AMPK activation. The... | related_sentences | [
"This effect was stimulated by NAC or CC"
] | [
"This effect was inhibited by NAC or CC"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041575_TII_02/figure/2010041575_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010002386"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041585_TII_02/figure/2010041585_TII_02_5.png | consistency_97 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | CPEB1 reduces senescence by regulating p53 distribution in glioma cells. (a) A cell growth assay was used to analyze the function of CPEB1 siRNA in glioma cell proliferation. *Po0.05. (b) The effect of CPEB1 siRNA on senescence in glioma cell lines as determined with SA-b-gal staining. Arrows indicate the green senesce... | The knockdown of CPEB1 reduced senescence by regulating p53 distribution in glioma cells. Burns DM et al.18 demonstrated that CPEB1 was repressed by miR-122, and the inhibition of CPEB1 activated p53 translation in human skin fibroblasts. p53 is one of the hallmarks of cellular senescence;19 therefore, the p53-mutated ... | related_sentences | [
"U251 and U87 cell growth was stimulated by CPEB1 knockdown"
] | [
"U251 and U87 cell growth was inhibited by CPEB1 knockdown"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041585_TII_02/figure/2010041585_TII_02_5.png"
],
"tampered": true,
"paper_ids": [
"2010002387"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010041660_TII_02/figure/2010041660_TII_02_3.png | consistency_98 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure4 Inhibition of ADAM17 modulates phosphorylation of p44 MAPK. (a) Levels of p44 MAPK phosphorylation were decreased after ADAM17 inhibition with medium and high concentrations of BMS-561392, whereas p42 MAPK phosphorylation was not affected in immature HOG oligodendrocytes. (b) Microglial BV-2 cells were treated ... | On the contrary, levels of p44 MAPK phosphorylation were significantly increased with the highest concentration of BMS-561392 (2.7mM) in oligodendrocytes (Figure 4a), whereas in microglial cells phosphorylation of p44 MAPK was significantly decreased by the lower concentration of BMS-561392 (0.3mM) and significantly di... | caption | [
"MAPK p44 phosphorylation was significantly decreased using 0.3mM of the inhibitor",
"levels of p44 MAPK phosphorylation were significantly increased with the highest concentration of BMS-561392 (2.7mM) in oligodendrocytes (Figure 4a)",
"whereas in microglial cells phosphorylation of p44 MAPK was significantly ... | [
"MAPK p44 phosphorylation was significantly increased using 0.3mM of the inhibitor",
"levels of p44 MAPK phosphorylation were significantly decreased with the highest concentration of BMS-561392 (2.7mM) in oligodendrocytes (Figure 4a)",
"whereas in microglial cells phosphorylation of p44 MAPK was significantly ... | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041660_TII_02/figure/2010041660_TII_02_3.png"
],
"tampered": true,
"paper_ids": [
"2010002388"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} |
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