sample_id int32 1 55 | regulator_locus_tag stringlengths 7 7 | regulator_symbol stringlengths 4 7 | found_domain stringlengths 3 23 ⌀ | sgd_description stringlengths 20 240 | essential bool 2 classes | oe_passed_qc bool 2 classes | del_passed_qc bool 2 classes |
|---|---|---|---|---|---|---|---|
1 | YDL056W | MBP1 | APSES and Ank(3) | Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes | false | true | true |
2 | YDR096W | GIS1 | ZnF_C2H2(2) | Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1 | false | true | false |
3 | YDR123C | INO2 | HLH(1) | Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion | false | true | true |
4 | YDR213W | UPC2 | GAL4(1) | Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog | false | true | false |
5 | YDR216W | ADR1 | ZnF_C2H2(2) | Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization | false | true | false |
6 | YDR451C | YHP1 | HOX(1) | One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval | false | true | true |
7 | YEL009C | GCN4 | BZIP_1(1) and BZIP_2(1) | Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels | false | true | false |
8 | YER111C | SWI4 | APSES and Ank(2) | DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair | false | true | true |
9 | YER161C | SPT2 | null | Protein involved in negative regulation of transcription, exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins | false | false | false |
10 | YFL031W | HAC1 | BZIP_2(1) | bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis | false | true | false |
11 | YFR034C | PHO4 | HLH(1) | Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability | false | true | true |
12 | YGL035C | MIG1 | ZnF_C2H2(2) | Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins | false | true | false |
13 | YGL073W | HSF1 | HSF(3) | Trimeric heat shock transcription factor, activates multiple genes in response to hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; constitutively DNA-bound; posttranslationally regulated | true | true | false |
14 | YGL096W | TOS8 | HOX(2) | Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p | false | false | false |
15 | YGL162W | SUT1 | GAL4(1) | Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression | false | true | false |
16 | YGL166W | CUP2 | COPPER_FIST | Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations | false | true | false |
17 | YGR044C | RME1 | ZnF_C2H2(1) | Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation | false | true | false |
18 | YGR249W | MGA1 | HSF(2) | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants | false | true | false |
19 | YHR006W | STP2 | ZnF_C2H2(1) | Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes | false | true | true |
20 | YHR056C | RSC30 | GAL4(1) | One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive | false | true | false |
21 | YHR084W | STE12 | STE | Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth | false | true | false |
22 | YHR206W | SKN7 | HSF(1) | Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation | false | true | false |
23 | YIL036W | CST6 | BZIP_1(1) and BZIP_2(1) | Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources | false | true | true |
24 | YIL101C | XBP1 | null | Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate | false | true | false |
25 | YIR013C | GAT4 | ZnF_GATA(1) | Protein containing GATA family zinc finger motifs | false | true | false |
26 | YJL056C | ZAP1 | ZnF_C2H2(6) | Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains | false | true | false |
27 | YJL089W | SIP4 | GAL4(1) | C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus | false | false | false |
28 | YJL110C | GZF3 | ZnF_GATA(1) | GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p | false | true | false |
29 | YKL005C | BYE1 | ZF_PHD | Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit | false | false | false |
30 | YKL015W | PUT3 | GAL4(1) | Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain | false | true | false |
31 | YKL062W | MSN4 | ZnF_C2H2(2) | Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression | false | false | false |
32 | YKL109W | HAP4 | null | Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex | false | true | false |
33 | YKL112W | ABF1 | BAF1_ABF1 | DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair | true | true | false |
34 | YLR013W | GAT3 | ZnF_GATA(1) | Protein containing GATA family zinc finger motifs | false | true | false |
35 | YLR176C | RFX1 | RFX(1) | Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins | false | true | false |
36 | YLR228C | ECM22 | GAL4(1) | Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p | false | true | false |
37 | YLR375W | STP3 | ZnF_C2H2(1) | Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids | false | false | false |
38 | YLR403W | SFP1 | ZnF_C2H2(2) | Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation | false | true | true |
39 | YML007W | YAP1 | BZIP_1(1) | Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants | false | true | false |
40 | YML027W | YOX1 | HOX(1) | Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate | false | true | false |
41 | YMR016C | SOK2 | APSES | Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors | false | true | true |
42 | YMR037C | MSN2 | ZnF_C2H2(2) | Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression | false | true | false |
43 | YMR070W | MOT3 | ZnF_C2H2(1) | Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes | false | true | true |
44 | YMR182C | RGM1 | ZnF_C2H2(2) | Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth | false | true | false |
45 | YMR280C | CAT8 | GAL4(1) | Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements | false | false | false |
46 | YNL027W | CRZ1 | ZnF_C2H2(2) | Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation | false | true | false |
47 | YNL103W | MET4 | BZIP | Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p | true | true | false |
48 | YNL204C | SPS18 | ArfGap | Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation | false | false | false |
49 | YNL216W | RAP1 | SANT(1) | DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure | true | true | false |
50 | YNL255C | GIS2 | ZnF_C2HC(7) | Putative zinc finger protein with similarity to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway | false | false | false |
51 | YOR032C | HMS1 | HLH(1) | Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant | false | true | false |
52 | YOR162C | YRR1 | GAL4(1) | Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes | false | true | false |
53 | YPL038W | MET31 | ZnF_C2H2(2) | Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met32p | false | true | false |
54 | YPR015C | YPR015C | ZnF_C2H2(2) | Hypothetical protein | false | true | false |
55 | YPR065W | ROX1 | HMG(1) | Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity | false | true | false |
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