from __future__ import annotations import torch from torch import nn from .clinical_encoder import ClinicalEncoder from .ct_encoder import CTEncoder from .fusion import SelectivePETFusion from .pet_encoder import PETEncoder from .support_net import SupportNet from .survival_head import DiscreteTimeSurvivalHead class CohortAwareCTModel(nn.Module): """End-to-end model matching the paper's first-stage reproducible modules.""" def __init__( self, in_channels: int = 1, feature_dim: int = 256, clinical_dim: int = 0, survival_bins: int = 0, use_pet: bool = True, use_support: bool = True, clinical_use_missingness: bool = True, gate_mode: str = "selective", ) -> None: super().__init__() self.use_pet = use_pet self.use_support = use_support self.support_net = SupportNet(in_channels=in_channels) self.ct_encoder = CTEncoder(in_channels=in_channels + 1, feature_dim=feature_dim) self.pet_encoder = PETEncoder(in_channels=1, feature_dim=feature_dim) if use_pet else None self.clinical_encoder = ClinicalEncoder( clinical_dim=clinical_dim, feature_dim=feature_dim, use_missingness=clinical_use_missingness, ) self.fusion = SelectivePETFusion(feature_dim=feature_dim, gate_mode=gate_mode) self.survival_head = ( DiscreteTimeSurvivalHead(in_dim=feature_dim * 3, num_bins=survival_bins) if survival_bins > 0 else None ) def forward(self, batch: dict[str, torch.Tensor]) -> dict[str, torch.Tensor]: ct = batch["ct"].float() support_logits = self.support_net(ct) support_prob = torch.sigmoid(support_logits) if self.use_support else torch.zeros_like(support_logits) ct_feat = self.ct_encoder(torch.cat([ct, support_prob], dim=1)) clinical_feat = self.clinical_encoder(batch.get("clinical"), batch.get("clinical_missing")) pet_feat = None if self.use_pet and self.pet_encoder is not None and "pet" in batch: pet_feat = self.pet_encoder(batch["pet"].float()) out = self.fusion( ct_feat=ct_feat, clinical_feat=clinical_feat, pet_feat=pet_feat, has_pet=batch.get("has_pet") if self.use_pet else torch.zeros(ct_feat.shape[0], device=ct_feat.device), ) out["support_logits"] = support_logits out["support_prob"] = support_prob out["lesion_prob"] = torch.sigmoid(out["fused_logit"]) if self.survival_head is not None: out["hazard_logits"] = self.survival_head(out["fused_features"]) return out