from __future__ import annotations import argparse from pathlib import Path import torch import torch.nn.functional as F import yaml from torch.utils.data import DataLoader, random_split from src.datasets import LIDCDataset, LungPETCTDxDataset, ManifestDataset, NSCLCRadiomicsDataset from src.losses import brier_loss, discrete_time_nll, segmentation_loss from src.models import CohortAwareCTModel def build_dataset(cfg: dict): ds = cfg["dataset"] name = ds["name"] kwargs = { "manifest_csv": ds["manifest_csv"], "root": ds.get("root"), "clinical_cols": ds.get("clinical_cols", []), } if name == "lidc": return LIDCDataset(task=cfg.get("task", "classification"), **kwargs) if name == "lung_pet_ct_dx": return LungPETCTDxDataset(**kwargs) if name == "nsclc_radiomics": return NSCLCRadiomicsDataset(**kwargs) return ManifestDataset(**kwargs) def collate_optional(batch: list[dict]) -> dict: out: dict = {} keys = set().union(*(item.keys() for item in batch)) for key in keys: values = [item.get(key) for item in batch] if isinstance(values[0], torch.Tensor): if all(v is not None and tuple(v.shape) == tuple(values[0].shape) for v in values): out[key] = torch.stack(values) elif key in ("patient_id", "lesion_id"): out[key] = values return out def build_loss(outputs: dict[str, torch.Tensor], batch: dict[str, torch.Tensor], task: str) -> torch.Tensor: return build_weighted_loss(outputs, batch, task) def build_weighted_loss( outputs: dict[str, torch.Tensor], batch: dict[str, torch.Tensor], task: str, calibration_weight: float = 0.05, ) -> torch.Tensor: losses = [] if "mask" in batch and "support_logits" in outputs: losses.append(segmentation_loss(outputs["support_logits"], batch["mask"])) if "label" in batch and not torch.isnan(batch["label"]).all(): label = torch.nan_to_num(batch["label"].float(), nan=0.0) losses.append(F.binary_cross_entropy_with_logits(outputs["fused_logit"], label)) losses.append(0.2 * F.binary_cross_entropy_with_logits(outputs["ct_logit"], label)) if calibration_weight > 0: losses.append(calibration_weight * brier_loss(outputs["fused_logit"], label)) if task == "survival" and "hazard_logits" in outputs and "time" in batch and "event" in batch: bin_index = torch.nan_to_num(batch["time"], nan=0.0).long() event = torch.nan_to_num(batch["event"], nan=0.0) losses.append(discrete_time_nll(outputs["hazard_logits"], bin_index, event)) if not losses: raise ValueError("No supervised targets found in batch") return sum(losses) def main() -> None: parser = argparse.ArgumentParser(description="Train a reproduction model.") parser.add_argument("--config", required=True) args = parser.parse_args() cfg = yaml.safe_load(Path(args.config).read_text()) torch.manual_seed(int(cfg.get("seed", 17))) dataset = build_dataset(cfg) train_len = max(1, int(0.8 * len(dataset))) val_len = len(dataset) - train_len train_ds, _ = random_split(dataset, [train_len, val_len], generator=torch.Generator().manual_seed(cfg.get("seed", 17))) train_cfg = cfg["train"] loader = DataLoader( train_ds, batch_size=train_cfg.get("batch_size", 2), shuffle=True, num_workers=train_cfg.get("num_workers", 0), collate_fn=collate_optional, ) model_cfg = cfg["model"] model = CohortAwareCTModel( in_channels=model_cfg.get("in_channels", 1), feature_dim=model_cfg.get("feature_dim", 256), clinical_dim=model_cfg.get("clinical_dim", 0), survival_bins=model_cfg.get("survival_bins", 0), use_pet=model_cfg.get("use_pet", True), use_support=model_cfg.get("use_support", True), clinical_use_missingness=model_cfg.get("clinical_use_missingness", True), gate_mode=model_cfg.get("gate_mode", "selective"), ) device = torch.device("cuda" if torch.cuda.is_available() else "cpu") model.to(device) opt = torch.optim.AdamW(model.parameters(), lr=train_cfg.get("lr", 1e-4), weight_decay=1e-4) out_dir = Path(train_cfg["output_dir"]) out_dir.mkdir(parents=True, exist_ok=True) for epoch in range(int(train_cfg.get("epochs", 1))): model.train() total = 0.0 for batch in loader: batch = {k: v.to(device) if isinstance(v, torch.Tensor) else v for k, v in batch.items()} opt.zero_grad(set_to_none=True) outputs = model(batch) loss = build_weighted_loss( outputs, batch, cfg.get("task", "classification"), calibration_weight=float(train_cfg.get("calibration_weight", 0.05)), ) loss.backward() opt.step() total += float(loss.detach().cpu()) ckpt = {"model": model.state_dict(), "config": cfg, "epoch": epoch} torch.save(ckpt, out_dir / "last.pt") print(f"epoch={epoch + 1} loss={total / max(len(loader), 1):.4f}") if __name__ == "__main__": main()