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# Copyright (c) MONAI Consortium
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
# http://www.apache.org/licenses/LICENSE-2.0
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.
from __future__ import annotations
from typing import Any, cast
import numpy as np
import torch
from monai.config import NdarrayOrTensor
def compute_fp_tp_probs_nd(
probs: NdarrayOrTensor,
coords: NdarrayOrTensor,
evaluation_mask: NdarrayOrTensor,
labels_to_exclude: list | None = None,
) -> tuple[NdarrayOrTensor, NdarrayOrTensor, int]:
"""
This function is modified from the official evaluation code of
`CAMELYON 16 Challenge <https://camelyon16.grand-challenge.org/>`_, and used to distinguish
true positive and false positive predictions. A true positive prediction is defined when
the detection point is within the annotated ground truth region.
Args:
probs: an array with shape (n,) that represents the probabilities of the detections.
Where, n is the number of predicted detections.
coords: an array with shape (n, n_dim) that represents the coordinates of the detections.
The dimensions must be in the same order as in `evaluation_mask`.
evaluation_mask: the ground truth mask for evaluation.
labels_to_exclude: labels in this list will not be counted for metric calculation.
Returns:
fp_probs: an array that contains the probabilities of the false positive detections.
tp_probs: an array that contains the probabilities of the True positive detections.
num_targets: the total number of targets (excluding `labels_to_exclude`) for all images under evaluation.
"""
if not (len(probs) == len(coords)):
raise ValueError(f"the length of probs {probs.shape}, should be the same as of coords {coords.shape}.")
if not (len(coords.shape) > 1 and coords.shape[1] == len(evaluation_mask.shape)):
raise ValueError(
f"coords {coords.shape} need to represent the same number of dimensions as mask {evaluation_mask.shape}."
)
if isinstance(probs, torch.Tensor):
probs = probs.detach().cpu().numpy()
if isinstance(coords, torch.Tensor):
coords = coords.detach().cpu().numpy()
if isinstance(evaluation_mask, torch.Tensor):
evaluation_mask = evaluation_mask.detach().cpu().numpy()
if labels_to_exclude is None:
labels_to_exclude = []
max_label = np.max(evaluation_mask)
tp_probs = np.zeros((max_label,), dtype=np.float32)
hittedlabel = evaluation_mask[tuple(coords.T)]
fp_probs = probs[np.where(hittedlabel == 0)]
for i in range(1, max_label + 1):
if i not in labels_to_exclude and i in hittedlabel:
tp_probs[i - 1] = probs[np.where(hittedlabel == i)].max()
num_targets = max_label - len(labels_to_exclude)
return fp_probs, tp_probs, cast(int, num_targets)
def compute_fp_tp_probs(
probs: NdarrayOrTensor,
y_coord: NdarrayOrTensor,
x_coord: NdarrayOrTensor,
evaluation_mask: NdarrayOrTensor,
labels_to_exclude: list | None = None,
resolution_level: int = 0,
) -> tuple[NdarrayOrTensor, NdarrayOrTensor, int]:
"""
This function is modified from the official evaluation code of
`CAMELYON 16 Challenge <https://camelyon16.grand-challenge.org/>`_, and used to distinguish
true positive and false positive predictions. A true positive prediction is defined when
the detection point is within the annotated ground truth region.
Args:
probs: an array with shape (n,) that represents the probabilities of the detections.
Where, n is the number of predicted detections.
y_coord: an array with shape (n,) that represents the Y-coordinates of the detections.
x_coord: an array with shape (n,) that represents the X-coordinates of the detections.
evaluation_mask: the ground truth mask for evaluation.
labels_to_exclude: labels in this list will not be counted for metric calculation.
resolution_level: the level at which the evaluation mask is made.
Returns:
fp_probs: an array that contains the probabilities of the false positive detections.
tp_probs: an array that contains the probabilities of the True positive detections.
num_targets: the total number of targets (excluding `labels_to_exclude`) for all images under evaluation.
"""
if isinstance(y_coord, torch.Tensor):
y_coord = y_coord.detach().cpu().numpy()
if isinstance(x_coord, torch.Tensor):
x_coord = x_coord.detach().cpu().numpy()
y_coord = (y_coord / pow(2, resolution_level)).astype(int)
x_coord = (x_coord / pow(2, resolution_level)).astype(int)
stacked = np.stack([y_coord, x_coord], axis=1)
return compute_fp_tp_probs_nd(
probs=probs, coords=stacked, evaluation_mask=evaluation_mask, labels_to_exclude=labels_to_exclude
)
def compute_froc_curve_data(
fp_probs: np.ndarray | torch.Tensor, tp_probs: np.ndarray | torch.Tensor, num_targets: int, num_images: int
) -> tuple[np.ndarray, np.ndarray]:
"""
This function is modified from the official evaluation code of
`CAMELYON 16 Challenge <https://camelyon16.grand-challenge.org/>`_, and used to compute
the required data for plotting the Free Response Operating Characteristic (FROC) curve.
Args:
fp_probs: an array that contains the probabilities of the false positive detections for all
images under evaluation.
tp_probs: an array that contains the probabilities of the True positive detections for all
images under evaluation.
num_targets: the total number of targets (excluding `labels_to_exclude`) for all images under evaluation.
num_images: the number of images under evaluation.
"""
if not isinstance(fp_probs, type(tp_probs)):
raise AssertionError("fp and tp probs should have same type.")
if isinstance(fp_probs, torch.Tensor):
fp_probs = fp_probs.detach().cpu().numpy()
if isinstance(tp_probs, torch.Tensor):
tp_probs = tp_probs.detach().cpu().numpy()
total_fps, total_tps = [], []
all_probs = sorted(set(list(fp_probs) + list(tp_probs)))
for thresh in all_probs[1:]:
total_fps.append((fp_probs >= thresh).sum())
total_tps.append((tp_probs >= thresh).sum())
total_fps.append(0)
total_tps.append(0)
fps_per_image = np.asarray(total_fps) / float(num_images)
total_sensitivity = np.asarray(total_tps) / float(num_targets)
return fps_per_image, total_sensitivity
def compute_froc_score(
fps_per_image: np.ndarray, total_sensitivity: np.ndarray, eval_thresholds: tuple = (0.25, 0.5, 1, 2, 4, 8)
) -> Any:
"""
This function is modified from the official evaluation code of
`CAMELYON 16 Challenge <https://camelyon16.grand-challenge.org/>`_, and used to compute
the challenge's second evaluation metric, which is defined as the average sensitivity at
the predefined false positive rates per whole slide image.
Args:
fps_per_image: the average number of false positives per image for different thresholds.
total_sensitivity: sensitivities (true positive rates) for different thresholds.
eval_thresholds: the false positive rates for calculating the average sensitivity. Defaults
to (0.25, 0.5, 1, 2, 4, 8) which is the same as the CAMELYON 16 Challenge.
"""
interp_sens = np.interp(eval_thresholds, fps_per_image[::-1], total_sensitivity[::-1])
return np.mean(interp_sens)
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