---
license: mit
---
---
license: mit
language:
- en
pretty_name: ABX-CT-003 Collateral Sensitivity Pattern
tags:
- antibiotics
- combination-therapy
- collateral-sensitivity
- mic
- resistance
- tabular
task_categories:
- tabular-classification
size_categories:
- n<1k
---

ABX-CT-003 Collateral Sensitivity Pattern

Purpose

Detect the paired pattern where resistance to Drug A coincides with increased sensitivity to Drug B.

Core pattern

- stress_index high
- Drug A MIC crosses a_resistant_cutoff_mg_L
- Drug B MIC drops at least 2x vs baseline and reaches a low floor
- Drug B drop occurs at the same or next timepoint in v1

Files

- data/train.csv
- data/test.csv
- scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

- row_id
- series_id
- timepoint_h
- organism
- strain_id
- drug_a
- drug_b
- stress_index
- baseline_mic_a_mg_L
- baseline_mic_b_mg_L
- mic_a_mg_L
- mic_b_mg_L
- a_resistant_cutoff_mg_L
- b_susceptible_floor_mg_L
- b_sensitivity_fold_change
- media
- assay_method
- source_type
- collateral_sensitivity_signal
- earliest_collateral_sensitivity

Labels

- collateral_sensitivity_signal
  - 1 for rows at or after the first detected collateral sensitivity row

- earliest_collateral_sensitivity
  - 1 only for the first detected row in that series

Scorer logic in v1

- baseline Drug A must be below resistant cutoff
- find first time Drug A crosses resistant cutoff under stress
- collateral sensitivity triggers if Drug B at the same or next timepoint
  - drops by at least 2x vs baseline
  - reaches b_susceptible_floor_mg_L or lower

Evaluation

Run

- python scorer.py --path data/test.csv