| | row_id,series_id,timepoint_h,host_model,drug,plasma_conc_mg_L,csf_conc_mg_L,expected_csf_conc_mg_L,csf_deviation,bbb_penetration_ratio,expected_bbb_ratio,ratio_deviation,neuro_marker_index,neuro_coherence_index,exposure_index,stress_index,later_severe_neuro_flag,assay_method,source_type,neuro_threshold_shift_signal,earliest_neuro_threshold_shift,notes |
| | ABXHT005-TR-0001,S1,0,human_sim,cefepime,10.0,0.50,0.50,0.00,0.050,0.050,0.000,0.10,0.90,0.10,0.10,0,pk_csf_neuro_panel,simulated,0,0,baseline |
| | ABXHT005-TR-0002,S1,12,human_sim,cefepime,12.0,0.60,0.60,0.00,0.050,0.050,0.000,0.12,0.88,0.85,0.90,0,pk_csf_neuro_panel,simulated,0,0,tracks expected |
| | ABXHT005-TR-0003,S1,24,human_sim,cefepime,12.0,1.10,0.60,0.50,0.092,0.050,0.042,0.55,0.35,0.90,0.90,0,pk_csf_neuro_panel,simulated,0,0,first shift |
| | ABXHT005-TR-0004,S1,36,human_sim,cefepime,12.0,1.30,0.60,0.70,0.108,0.050,0.058,0.62,0.30,0.90,0.90,0,pk_csf_neuro_panel,simulated,1,1,confirmed onset |
| | ABXHT005-TR-0005,S1,72,human_sim,cefepime,12.0,2.40,0.60,1.80,0.200,0.050,0.150,0.85,0.20,0.90,0.90,1,pk_csf_neuro_panel,simulated,1,0,severe later |
| | ABXHT005-TR-0006,S2,0,human_sim,meropenem,15.0,0.30,0.30,0.00,0.020,0.020,0.000,0.10,0.90,0.10,0.10,0,pk_csf_neuro_panel,simulated,0,0,baseline |
| | ABXHT005-TR-0007,S2,24,human_sim,meropenem,16.0,0.32,0.32,0.00,0.020,0.020,0.000,0.12,0.86,0.90,0.90,0,pk_csf_neuro_panel,simulated,0,0,stable |
| | ABXHT005-TR-0008,S2,48,human_sim,meropenem,16.0,0.33,0.33,0.00,0.021,0.020,0.001,0.12,0.84,0.90,0.90,0,pk_csf_neuro_panel,simulated,0,0,stable |
| | ABXHT005-TR-0009,S3,0,human_sim,cefepime,10.0,1.80,0.50,1.30,0.180,0.050,0.130,0.70,0.30,0.90,0.90,1,pk_csf_neuro_panel,simulated,0,0,baseline ratio high |
| | ABXHT005-TR-0010,S4,0,human_sim,cefepime,12.0,1.30,0.60,0.70,0.108,0.050,0.058,0.62,0.30,0.90,0.30,1,pk_csf_neuro_panel,simulated,0,0,stress low |
| |
|
