README.md

---
license: mit
language:
- en
pretty_name: ABX-HT-007 Allergic Sensitization Pattern
tags:
- antibiotics
- toxicity
- allergy
- hypersensitivity
- immune
- eosinophils
- tryptase
- tabular
task_categories:
- tabular-classification
size_categories:
- n<1k
---

ABX-HT-007 Allergic Sensitization Pattern

Purpose

Detect early allergic sensitization when immune response markers stop tracking treatment duration before hypersensitivity events.

Core pattern

- host_stress_index high
- duration_exposure_index high
- immune_coherence_index drops
- eos_rise_vs_expected or tryptase_rise_vs_expected stays high
- later_hypersensitivity_flag appears

Files

- data/train.csv
- data/test.csv
- scorer.py

Schema

Each row is one timepoint in a within series treatment course.

Required columns

- row_id
- series_id
- treatment_day
- host_model
- drug
- duration_exposure_index
- total_dose_mg
- expected_total_dose_mg
- dose_deviation
- eos_percent
- expected_eos_percent
- eos_rise_vs_expected
- tryptase_ng_mL
- expected_tryptase_ng_mL
- tryptase_rise_vs_expected
- immune_coherence_index
- host_stress_index
- later_hypersensitivity_flag
- assay_method
- source_type
- allergic_sensitization_signal
- earliest_allergic_sensitization

Labels

- allergic_sensitization_signal
  - 1 for rows at or after first confirmed sensitization onset

- earliest_allergic_sensitization
  - 1 only for the first onset row in that series

Scorer logic in v1

- exclude series with high baseline eosinophils
- candidate onset point
  - host_stress_index at least 0.80
  - duration_exposure_index at least 0.80
  - immune_coherence_index at most 0.40
  - eos_rise_vs_expected at least 3.0 or tryptase_rise_vs_expected at least 5.0
  - for two consecutive points
  - ignore one point eosinophil spike then recovery artifacts
- confirmation
  - later_hypersensitivity_flag equals 1 later in series

Evaluation

Run

- python scorer.py --path data/test.csv