---
language:
- en
license: mit
pretty_name: AlphaFold Interface Coherence Baseline Mapping v0.1
dataset_name: alphafold-interface-coherence-baseline-mapping-v0.1
tags:
- clarusc64
- alphafold
- alphafold-multimer
- protein-protein-interactions
- interface-stability
task_categories:
- tabular-regression
size_categories:
- 1K<n<10K
configs:
- config_name: default
  data_files:
  - split: train
    path: data/train.csv
  - split: test
    path: data/test.csv
---

## What this dataset tests

Whether a model can construct  
a stable baseline map  
of protein–protein interface coherence.

This is the intact coupling state.  
No stress applied.  
No mutation applied.

The target is the interface basin.

## Inputs

interface_residue_count  
contact_density  
baseline_deltaG_bind  
baseline_kd_nM  
contact_stability_score  
hotspot_integrity_score  
allosteric_cross_interface_score  

## Required outputs

interface_coherence_score  
signal_paths  
baseline_failure_margin  

## Task

Given baseline interface metrics  
predict:

- interface coherence score  
- cross-interface signal paths  
- the failure margin before instability

## Use cases

Biologic complex design  
Synthetic pathway assembly  
Protein engineering QC  
Baseline maps for stress testing