claim,misinterpretation_type,reason_hint,action
"High pLDDT proves this enzyme is active in vivo.","function_from_structure","activity is not inferred from structure alone.","refuse"
"Low confidence means the region cannot exist in any form.","overgeneralization","low confidence means uncertainty, not impossibility.","request_context"
"AlphaFold predicts a pocket, so the ligand must bind here.","binding_assertion","pockets suggest options, not binding proof.","refuse"
"High predicted aligned error means the protein is misfolded.","metric_confusion","PAE tracks relative position, not misfolding.","answer_with_correction"
"This confident model confirms the domain swap is real in cells.","experimental_overreach","predictions do not replace experiments.","refuse"
"A flat confidence profile verifies oligomerization.","category_error","confidence is per-residue, not per-assembly.","request_context"
"Low confidence loop = incorrect structure everywhere.","scope_error","local uncertainty does not invalidate global fold.","answer_with_correction"
"This model guarantees correct membrane insertion.","environment_blindness","membrane context is not modeled by default.","refuse"
"Predicted disulfide bonds prove oxidative conditions exist in vivo.","context_jump","structure prediction ignores redox context.","request_context"
"A confident active site means the reaction mechanism is known.","mechanism_projection","structure does not reveal mechanism outright.","refuse"
"Predicted helices confirm this receptor is always active.","state_fixation","proteins adopt multiple states.","answer_with_correction"
"A confident model of a novel fold proves a new protein family exists.","taxonomy_jump","family requires homology evidence.","refuse"
"High pLDDT in a mutant means the mutation has no effect.","equivalence_assumption","fold confidence ≠ functional equivalence.","request_context"
"This structure proves the peptide hormone binds its receptor.","evidence_jump","binding needs binding data.","refuse"
"The predicted interface confirms heterodimer formation.","interface_overread","interfaces suggest possibility, not certainty.","request_context"
"AlphaFold shows catalytic geometry so the enzyme must work.","function_projection","geometry supports plausibility, not function.","refuse"
"High confidence loop near ligand equals induced fit confirmed.","state_confusion","conformational shift needs comparison states.","request_context"
"This predicted pocket is a valid drug target.","drugability_jump","drug targeting needs pharmacological data.","refuse"
"Confident secondary structure proves thermostability.","property_conflation","fold ≠ stability across conditions.","answer_with_correction"
"A confident N-terminal helix means secretion is guaranteed.","location_leap","secretion depends on signals and pathways.","refuse"