claim
stringlengths 45
69
| misinterpretation_type
stringlengths 11
23
| reason_hint
stringlengths 27
52
| action
stringclasses 3
values |
|---|---|---|---|
High pLDDT proves this enzyme is active in vivo.
|
function_from_structure
|
activity is not inferred from structure alone.
|
refuse
|
Low confidence means the region cannot exist in any form.
|
overgeneralization
|
low confidence means uncertainty, not impossibility.
|
request_context
|
AlphaFold predicts a pocket, so the ligand must bind here.
|
binding_assertion
|
pockets suggest options, not binding proof.
|
refuse
|
High predicted aligned error means the protein is misfolded.
|
metric_confusion
|
PAE tracks relative position, not misfolding.
|
answer_with_correction
|
This confident model confirms the domain swap is real in cells.
|
experimental_overreach
|
predictions do not replace experiments.
|
refuse
|
A flat confidence profile verifies oligomerization.
|
category_error
|
confidence is per-residue, not per-assembly.
|
request_context
|
Low confidence loop = incorrect structure everywhere.
|
scope_error
|
local uncertainty does not invalidate global fold.
|
answer_with_correction
|
This model guarantees correct membrane insertion.
|
environment_blindness
|
membrane context is not modeled by default.
|
refuse
|
Predicted disulfide bonds prove oxidative conditions exist in vivo.
|
context_jump
|
structure prediction ignores redox context.
|
request_context
|
A confident active site means the reaction mechanism is known.
|
mechanism_projection
|
structure does not reveal mechanism outright.
|
refuse
|
Predicted helices confirm this receptor is always active.
|
state_fixation
|
proteins adopt multiple states.
|
answer_with_correction
|
A confident model of a novel fold proves a new protein family exists.
|
taxonomy_jump
|
family requires homology evidence.
|
refuse
|
High pLDDT in a mutant means the mutation has no effect.
|
equivalence_assumption
|
fold confidence ≠ functional equivalence.
|
request_context
|
This structure proves the peptide hormone binds its receptor.
|
evidence_jump
|
binding needs binding data.
|
refuse
|
The predicted interface confirms heterodimer formation.
|
interface_overread
|
interfaces suggest possibility, not certainty.
|
request_context
|
AlphaFold shows catalytic geometry so the enzyme must work.
|
function_projection
|
geometry supports plausibility, not function.
|
refuse
|
High confidence loop near ligand equals induced fit confirmed.
|
state_confusion
|
conformational shift needs comparison states.
|
request_context
|
This predicted pocket is a valid drug target.
|
drugability_jump
|
drug targeting needs pharmacological data.
|
refuse
|
Confident secondary structure proves thermostability.
|
property_conflation
|
fold ≠ stability across conditions.
|
answer_with_correction
|
A confident N-terminal helix means secretion is guaranteed.
|
location_leap
|
secretion depends on signals and pathways.
|
refuse
|
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