id,condition_family,medication_set,baseline_coherence_metrics,post_combination_coherence_metrics,variance_shift,synchrony_shift,net_coherence_score,interpretation,notes,constraints,gold_checklist
CCP-001,diabetes,"metformin + GLP1","High glucose variance; low activity–sleep coupling","Lower glucose variance; improved sleep–activity coupling","Decrease","Increase","High","System-wide coherence gain","Upstream appetite and insulin effects align","Under 220 words.","baseline+post+score"
CCP-002,heart_failure,"ACEi + beta-blocker + diuretic","BP variability; exertional intolerance","BP stabilized; functional tolerance improved","Decrease","Increase","High","Coherent combination","Classic guideline synergy","Under 220 words.","baseline+post+score"
CCP-003,autoimmune,"steroid + NSAID","Low symptom score; high lab volatility","Symptoms quiet; lab variance increases","Increase","Decrease","Low","Cosmetic suppression","Fragility masked","Under 220 words.","baseline+post+score"
CCP-004,psychiatric,"SSRI + benzodiazepine","Anxiety spikes; sleep fragmented","Anxiety lower; sleep fragmented persists","Neutral","Neutral","Medium","Partial coherence","Symptom relief without system alignment","Under 220 words.","baseline+post+score"
CCP-005,respiratory,"ICS + LABA","Frequent wheeze; eosinophils high","Wheeze reduced; eosinophils lower","Decrease","Increase","High","Coherent airway control","Aligned inflammatory and functional effects","Under 220 words.","baseline+post+score"
CCP-006,cardiac,"antiarrhythmic + stimulant","HR variability unstable","Arrhythmia suppressed; autonomic volatility rises","Increase","Decrease","Low","Hidden antagonism","Control with systemic cost","Under 220 words.","baseline+post+score"