| id,disease_basin,candidate_drug,trial_outcome_summary,failure_mode_evidence,candidate_subgroup_axes,responder_subgroup_signature,non_responder_signature,context_gates,failure_mode_class,salvage_hypothesis,verification_plan,notes,constraints,gold_checklist | |
| FCSC-T01,heart_failure_fragility_basin,"candidate vasodilator","No mortality benefit overall","Functional benefit in patients with high afterload","afterload; renal sensitivity","High afterload; stable renal function","Low afterload; renal fragile","diuretic dose; BP floor","context-gated benefit","Use in high afterload niche with renal monitoring","Stratify by afterload; function endpoints","Must detect niche and gate","Under 280 words.","subgroup+gate+class+plan" | |