id,genotype_context,phenotype_label,phenotype_definition,measurement_source,stability_over_time,proxy_flags,biological_validity_assessment,downstream_model_risk,notes,constraints,gold_checklist
PDI-001,PRS,"Depression","SSRI prescription within 12 months","EHR prescription data","Low","Medication as proxy","Heterogeneous; non-specific","irreproducible associations","Classic proxy phenotype","Under 220 words.","definition+proxy+risk"
PDI-002,rare_variant,"Epilepsy","Single ICD-10 code","Administrative coding","Low","Billing proxy","Poor biological specificity","false genetic signals","ICD misuse","Under 220 words.","definition+proxy+risk"
PDI-003,LoF gene,"Hypercholesterolemia","LDL >190 mg/dL on 2 occasions","Lab measurements","High","None","Biologically grounded","stable modeling","Good phenotype","Under 220 words.","definition+proxy+risk"
PDI-004,GWAS,"Asthma","Self-reported diagnosis","Questionnaire","Medium","Self-report bias","Variable construct","noise amplification","Survey instability","Under 220 words.","definition+proxy+risk"
PDI-005,PRS,"Obesity","BMI >30","Anthropometrics","Medium","BMI as proxy","Partial metabolic signal","context-dependent risk","BMI collapse","Under 220 words.","definition+proxy+risk"