| id,combination,indication_context,data_sources,baseline_state_summary,post_combo_state_summary,cross_system_markers,combination_coherence_score,dominant_response_basin,cross_system_alignment_vector,early_incoherence_flags,net_functional_shift,notes,constraints,gold_checklist | |
| CSP-001,"PD1i + CTLA4i","melanoma","tumor; cytokines; RWE","high tumor burden; baseline autoimmunity low","response up; colitis signals emerging","tumor_resp; IL6; CRP; stool","0.62","anti_tumor_gain_fragile","tumor:+; immune_toxicity:+; inflammation:+","early GI immune toxicity","net positive fragile","Under 260 words","score+basin+vector+flags+shift" | |
| CSP-002,"SGLT2i + ARNI","HFrEF","clinical; labs; RWE","high NTproBNP; edema; low activity","NTproBNP down; edema down; function up","NTproBNP; creat; BP; steps","0.84","cardio_renal_stability","cardio:+; renal:+; function:+; BP:~","none","net positive stable","Under 260 words","score+basin+vector+flags+shift" | |
| CSP-003,"TNFi + MTX","RA","clinical; CRP; RWE","high CRP; joint pain; anemia","CRP down; pain down; infection signals mild","CRP; pain; WBC; infections","0.76","inflammation_resolution","immune:+; symptoms:+; infection_risk:+","infection risk emerging","net positive with risk","Under 260 words","score+basin+vector+flags+shift" | |
| CSP-004,"statin + clarithromycin","hyperlipidemia","RWE; labs","stable lipids; normal CK","CK up; weakness; liver enzymes up","CK; ALT; symptoms","0.28","toxicity_shift","muscle:-; hepatic:-; function:-","interaction toxicity","net negative","Under 260 words","score+basin+vector+flags+shift" | |
| CSP-005,"metformin + GLP1RA","T2D obesity","clinical; labs","high HbA1c; high weight; CRP mild","HbA1c down; weight down; nausea up","HbA1c; weight; GI AEs","0.80","metabolic_flexibility_gain","metabolic:+; inflammation:+; gut:-","GI intolerance","net positive","Under 260 words","score+basin+vector+flags+shift" | |
| CSP-006,"SSRI + NSAID","depression pain","RWE","mood low; pain high; normal Hb","Hb down; GI bleed risk up; mood slight up","Hb; stool; mood","0.40","mixed_gain_with_bleed_risk","mood:+; bleed_risk:+; inflammation:~","bleed risk","net mixed","Under 260 words","score+basin+vector+flags+shift" | |