| id,platform,compound_or_toxicant,dose_context,precursor_pattern_label,decoherence_onset_time,early_signature_set,affected_coupling_edges,observed_or_expected_damage_endpoints,collapse_dynamics_summary,collapse_topology_class,propagation_pathway,primary_failure_module,failure_horizon_estimate,reversibility_window,minimal_intervention_set,residual_risk_after_intervention,notes,constraints,gold_checklist | |
| TCTM-001,"multi-tissue organ-on-chip","acetaminophen","high; hepatotoxic range","pattern_alpha_hepatic_decoherence","t=10h","ROS rise; bile acid drift; clearance decouple; liver-only stress","liver-kidney clearance; liver-heart energetics","ALT proxy rise; ATP fall; inflammatory spillover","liver stress amplifies then spills to kidney; late systemic inflammation","single-node collapse with downstream spillover","liver -> kidney -> systemic cytokines","liver","48h","10-18h","dose de-rate; antioxidant support; increase clearance support; stop compound","0.35","intervention works early only","Under 280 words","topology+path+module+horizon+window+fix+risk" | |
| TCTM-002,"organoid panel","doxorubicin","moderate; cardiotoxic range","pattern_beta_cardiac_decoherence","t=16h","QT dispersion; heart-only mito stress; rhythm-energy decouple","heart-immune coupling; heart-liver energetics","rhythm collapse; troponin proxy rise","cardiac instability grows; immune response follows damage","bifurcation with abrupt event","heart instability -> arrhythmia event -> immune activation","heart","52h","16-28h","electrolyte stabilization; reduce dose; cardio-protectant co-therapy; halt if QT expands","0.45","moderate residual risk","windows tight","Under 280 words","topology+path+module+horizon+window+fix+risk" | |
| TCTM-003,"microphysiology system","cisplatin","high; nephrotoxic range","pattern_gamma_renal_decoherence","t=24h","clearance slowdown; kidney proteome stress; immune-lag divergence","kidney-immune quiet coupling; kidney-liver clearance","creat proxy rise; electrolyte instability","renal stress builds; immune activation occurs late; then systemic issues","slow drift then cliff","kidney drift -> electrolyte instability -> systemic destabilization","kidney","72h","24-40h","hydration protocol; nephroprotective agent; dose delay; monitoring trigger bundle","0.40","some risk persists","drift detectable","Under 280 words","topology+path+module+horizon+window+fix+risk" | |
| TCTM-004,"hiPSC co-culture","tunicamycin","stress positive control","pattern_delta_UPR_collapse","t=6h","UPR surge; cross-module mito decouple; synchrony drop","hep-neuro mito coupling; cytokine alignment","ATP collapse; apoptosis markers","rapid global stress; little containment; system-wide collapse","global phase collapse","global UPR -> mito collapse -> apoptosis cascade","system-wide","18h","6-9h","remove stressor; chaperone support; reduce load; stop exposure","0.55","high residual risk","fast collapse","Under 280 words","topology+path+module+horizon+window+fix+risk" | |
| TCTM-005,"multi-omic screening","valproate","dose high; idiosyncratic risk","pattern_epsilon_metabolic_drift","t=20h","lactate rise; energy coupling weaken; ammonia proxy trend","liver-muscle energy coupling; liver-immune quiet","hyperammonemia proxy; CNS risk markers","metabolic drift propagates to neuro risk; then immune involvement","multi-module drift","liver metabolic drift -> muscle fatigue -> neuro risk markers","liver","60h","20-32h","dose reduction; carnitine support; monitor ammonia; stop if trend accelerates","0.38","residual risk low-moderate","idiosyncratic window","Under 280 words","topology+path+module+horizon+window+fix+risk" | |
| TCTM-006,"organoid panel","lipopolysaccharide","immune toxicant","pattern_zeta_inflammatory_shock","t=8h","IL6 surge; rhythm variance jump; immune-heart shockwave","immune-heart coupling; immune-liver stress","cytokine storm; rhythm collapse","immune spike destabilizes heart and liver rapidly","shockwave cascade","immune surge -> heart instability -> liver stress escalation","immune","30h","8-12h","anti-inflammatory block; supportive stabilization; isolate exposure; stop trigger","0.50","moderate-high residual risk","shock fast","Under 280 words","topology+path+module+horizon+window+fix+risk" | |