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OBJECTIVE |
To compare the transcatheter arterial chemoembolization (TACE) alone or plus radiofrequency ablation (RFA) in the treatment of single branch portal vein tumor thrombus(PVTT)in patients with hepatocellular carcinoma (HCC) so as to evaluate the safety, control rate, prognostic factors and overall survival. |
METHODS |
From January 2004 to December 2007, 50 HCC patients (< 5 cm in diameter and 3 parenchymal lesions) with concurrent PVTT were enrolled and treated by TACE alone or TACE plus RFA randomly (TACE, n = 25; TACE-RFA, n = 25). In TACE group, the intra-hepatic lesions received TACE sequentially with RFA; in TACE-RFA group, PVT... |
RESULTS |
Of all 50 HCC patients with single branch PVTT with TACE or RFA, 47 patients (TACE, n = 24; TACE-RFA, n = 23) received all the scheduled procedures and completed the follow-up. Two patients (8.3%) in TACE group had liver dysfunction versus none in TACE-RFA group, 2 patients (8.7%) developed bile duct injury in TACE-RFA... |
CONCLUSION |
RFA is both safe and efficacious to prolong survival in the treatment of single branch PVTT plus TACE in selected HCC patients. It may provide rationales for further studies of evaluating the outcome of RFA plus other therapies in the treatment of HCC with single branch PVTT.Pinch Loss Ameliorates Obesity, Glucose Into... |
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell–extracellular matrix adhesion and migration; however, their roles in adipose tissue and metabolism are unclear. Here we find that high-fat diet (HFD) feeding dramatically increases expression of Pinch1/2 proteins in white adipose tissue ... |
Bone remodeling is regulated by systemic and local factors, and glucocorticoids are hormones with a significant impact on the skeleton. Bone remodeling is tightly regulated, and bone formation occurs in areas of previously resorbed bone. Bone is continuously regenerated, a process that is carried out by basic multicell... |
Boiling heat transfer is a key thermal limit in nuclear systems. However, for decades, its modeling has relied on speculative hypotheses and a good dose of empiricism. As researchers now start to develop more mechanistic models, the need for high-quality high-resolution data on the bubble nucleation and growth cycle is... |
This paper summarized the recent developments in temperature-tolerance power supply for grid equipment, through the theoretical prediction, design synthesis and verification of key material systems, cell structure design, core mechanism and battery preparation engineering process, this report can develop batteries suit... |
Tuning the center frequencies and bandwidth of dual passbands using circular arc perturbation slot in compact substrate integrated waveguide (SIW) filter is presented here. A miniaturized SIW cavity is extracted from circular SIW cavity and perturbation slot is loaded to disturb the excited modes. After rightly placing... |
The Advanced Research Projects Agency (ARPA) has embarked on a comprehensive effort to advance the state-of-the-art in meteor burst (MB) communications. The principal ARPA MB link performance objective is the demonstration of daily-average MB link throughputs in excess of 1 kbps for unconstrained point-to-point communi... |
Purpose of reviewThe serum and glucocorticoid inducible kinase 1 (SGK1) is induced in the aldosterone sensitive distal nephron (ASDN) where it may stimulate Na+ reabsorption, partly by inhibiting ubiquitin ligase Nedd4-2-mediated retrieval of epithelial Na+ channel ENaC from the luminal membrane. We describe recent adv... |
This study aimed to investigate the mechanism of Jiedu Huoxue decoction (JDHXD) in type III prostatitis based on the NF‐κB signalling pathway. Twenty‐six Sprague–Dawley male rats were divided into blank control, model, positive (Prostate Plus), low‐dose JDHXD, medium‐dose JDHXD and high‐dose JDHXD groups. Type III pros... |
Sixty patients with neuroblastoma or ganglioneuroblastoma underwent MRI 87 procedures to detect and follow up bone marrow metastases. The detection of bone marrow metastases by MRI was evaluated with aspiration cytology. Relationships were investigated between bone metastases and bone marrow metastases that were morpho... |
From atoms to molecules and bio‐macromolecules, from organelles to cells, tissues, to the whole living system, nature shows us that the formation of complex systems with emergent properties originates from the hierarchical self‐assembly of single components in guided bottom‐up processes. By using DNA as a fundamental b... |
Sixty-two patients with mild hypertension were randomly assigned to receive no treatment, or 160 mg propranolol, or 200 mg metoprolol daily starting one week before elective surgery under anesthesia. The last dose was given two hours before anesthesia. Anesthesia consisted of induction with midazolam (2.5-5 mg) followe... |
A new kind of multitetrahedron sheath ternary ZnS-(CdS/Au) hetero-nanorod is prepared, in which one 1D ultrathin ZnS nanorod is integrated with segmented tetrahedron sheaths made of CdS, and more importantly, Au nanoparticles can be decorated in a targeted manner onto the vertexes and edges of CdS tetrahedron sheaths s... |
The present study aimed to investigate the effects of selective fatigue (i.e., one muscle of the quadriceps) on load sharing strategies during submaximal knee extensions. Shear wave elastography was used to measure muscle shear elastic modulus, as this is considered to be an index of individual muscle force. Sixteen pa... |
OBJECTIVE |
To identify the differentially expressed genes in cardinal ligament between patients with pelvic organ prolapse (POP) and postmenopausal women without POP by Human Genome Expression Chip and explore the potential molecular mechanism involved in POP. |
METHODS |
From January to May, 2007, cardinal ligament samples were obtained from 3 postmenopausal patients with POP-Q stage III and 3 postmenopausal patients underwent hysterectomy due to other benign gynecologic diseases without POP in Peking Union Medical College Hospital. HE and Masson's trichrome staining was used to verify... |
RESULTS |
Alterations of ligament architecture in POP patients included disarrangement and collapse of smooth muscle bundles and collagen fibers. A total of 179 differentially expressed genes were screened between POP and non-POP cardinal ligament tissue, including 20 functional unknown genes. A total of 107 genes were upregulat... |
CONCLUSIONS |
The pathophysiology of POP is complex and associated with multiple functional proteins and metabolic pathways. Among these, the antagonist DKK1, SFRP1 in Wnt signaling pathway may contribute to a neurodegenerative role in POP development.Stealing in eating disordered patients. |
Previous studies have noted high rates of stealing behavior in patients with eating disorders. To assess the significance of stealing in eating disordered patients, the authors compared the eating and purging behavior, levels of psychologic symptomatology, and alcohol use of 181 eating disordered patients with and with... |
Automatic detection of access control violations in software applications is a challenging problem. Insecure Direct Object Reference (IDOR) is among top-ranked vulnerabilities, which violates access control policies and cannot be yet detected by automated vulnerability scanners. While such tools may detect the absence ... |
Abstract In the dragonfly Perithemis tenera Say, males defend territories around oviposition sites and defense of a site is critical for reproductive success. This study first demonstrated that individual males varied consistently in how long they defended a particular territory within a day (their “tenure”) and in the... |
Numerous studies about geochemistry, formation and emplacement of carbonatites a priori assume that these are magmatic and represent melt composition. Unfortunately, almost all carbonatite rocks are not true melt compositions, but either represent primary cumulates or, more often, are strongly affected by fluid alterat... |
The burial environment of a fossil bone may be poorly suited to long-term preservation of important chemical constituents. Studies of fossil bone chemistry consequently benefit from knowledge of burial environmental change (burial history). Several techniques have been developed to describe alteration of fossil bone, i... |
A wavelet ECG data codec based on the Set Partitioning In Hierarchical Trees (SPIHT) compression algorithm is proposed in this paper. The SPIHT algorithm [1] has achieved notable success in still image coding. We modified the algorithm for the one-dimensional (1-D) case and applied it to compression of ECG data. Experi... |
Anecdotally, it has been suggested that prior viral infection increases heat stroke (HS) susceptibility and severity. HS and systemic infection have both been shown to induce disseminated intravascular coagulation (DIC), a condition associated with hypercoagulation, thrombocytopenia, multiorgan dysfunction, and higher ... |
Mucus is a biological gel that lines all wet epithelia in the body, including the eyes, lungs, and digestive tracts, and has evolved to protect us from pathogenic invasion. Microbial pathogenesis in these mucosal systems, however, is often studied in mucus‐free environments, which lack the geometric constraints and mic... |
REASONS FOR PERFORMING STUDY |
Osteochondritis dissecans (OCD) of the distal sagittal ridge of the third metacarpal bone (McIII) has not previously been described in the literature. |
OBJECTIVES |
To describe the clinical, radiological and arthroscopic features of OCD of the distal sagittal ridge of the McIII and to report outcome in a series of cases. |
STUDY DESIGN |
Retrospective case series. |
METHODS |
Case records and images of horses with OCD of the distal sagittal ridge of the McIII admitted to a single referral centre between February 2006 and February 2013 were reviewed. Follow-up information was obtained by telephone questionnaire and/or racing performance. |
RESULTS |
Osteochondritis dissecans of the distal sagittal ridge of the McIII was found in 16 lame horses; 9 unilaterally and 7 bilaterally. Lesions were consistently identified with flexed lateromedial radiographs and in 21 joints in dorsopalmar projections also. These were arthroscopically accessible from the dorsal compartmen... |
CONCLUSIONS |
Unlike more proximal lesions, OCD of the distal sagittal ridge appears to affect the McIII preferentially. Lesions were identified on dorsopalmar and flexed lateromedial radiographs only and are amenable to arthroscopic surgery. Clinicians should be aware of the potential for OCD to affect the distal sagittal ridge of ... |
The particle size, purity and form of the starting boron powders play an important role in the superconducting properties of MgB2. In this paper high-purity (99.999%) boron powders with crystalline phase that were processed by ball milling have been used as the precursor powders. It was observed that the critical curre... |
A 67 year old female whole trachea was compressed by malignant thyroid tumour complained of severe dyspnoea. Tracheostomy was considered but was rejected because of the risk of massive bleeding. Nasotracheal intubation improved markedly her condition. The patient underwent radiation and chemotheraphy with the tube in p... |
ABSTRACT Poor maternal mental health during the postpartum period can have significant effects on the health of mothers, infants, and families. The findings from cross-sectional studies suggest that stress and social support are related to maternal mental health. This study contributes to the literature through the use... |
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