text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
based on the immunostaining patterns , the prolamine proteins appeared to aggregate within the rough endoplasmic reticulum while most of the globulin appeared to aggregate in the vacuole . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
53,
61
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
141,
149
]
} |
it cross-reacts with a monoclonal antibody against phytochrome from etiolated corn ( zea ) and a polyclonal antibody against phytochrome from etiolated oat ( avena ) , and its photoreversibility is similar to that of phytochrome from greenavena . | NA | {
"id": "C0250581",
"name": "a",
"pos": [
11,
12
]
} | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
217,
228
]
} |
separation and quantitation of polyamines from unpollinated pea ( pisum sativum l. ) ovaries and young fruits induced by application of gibberellic acid to unpollinated ovaries showed , in both cases , a decrease in putrescine and spermidine levels between anthesis and 4 d later . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
216,
226
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
242,
248
]
} |
in all three species progesterone and 17alpha-hydroxyprogesterone could induce gvbd but relatively 17alpha,20beta-dihydroxyprogesterone was consistently found to be the most potent maturation-inducing steroid . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
21,
33
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
38,
65
]
} |
in all three species progesterone and 17alpha-hydroxyprogesterone could induce gvbd but relatively 17alpha,20beta-dihydroxyprogesterone was consistently found to be the most potent maturation-inducing steroid . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
21,
33
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
114,
135
]
} |
all 5beta-reduced pregnenes were effective in inducing gvbd inl . rohita but inc. catla , only 5beta-pregnane-17alpha-01-3,20-dione and 5beta-pregnane-3alpha,17alpha,20beta-triol and inc. mrigala , 5beta-pregnane-3alpha-ol-20- one could induce oocyte maturation . | NA | {
"id": "C0033014",
"name": "pregnenes",
"pos": [
18,
27
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
204,
212
]
} |
substitution of the position 6 glycine by d-amino acids renders the 5-6 bond resistant to degradation and shifts the main site of cleavage to the pro ( 9 ) -gly ( 10 ) nh2 bond . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
44,
55
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
157,
160
]
} |
the stimulation of ovulation can be blocked by indomethacin and restored by the subsequent addition of several primary prostaglandins ( goetz and theofan 1979 ) .in the present investigation , medium levels of prostaglandin f ( pgf ) and e ( pge ) were measured by radioimmunoassay duringin vitro 17alpha,20beta-p-induced ovulation of perch oocytes . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
119,
133
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
210,
225
]
} |
the stimulation of ovulation can be blocked by indomethacin and restored by the subsequent addition of several primary prostaglandins ( goetz and theofan 1979 ) .in the present investigation , medium levels of prostaglandin f ( pgf ) and e ( pge ) were measured by radioimmunoassay duringin vitro 17alpha,20beta-p-induced ovulation of perch oocytes . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
119,
133
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
242,
245
]
} |
cortisol , testosterone , estradiol-17beta , 17alpha,20alpha-dihydroxy-4-pregnen-3-one and 17alpha-hydorxyprogesterone did not increase pgf levels by 48h of incubation , however , several other progestational steroids including 20beta-dihydroprogesterone ( 20beta-p ) and progesterone did . | NA | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
235,
254
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
272,
284
]
} |
while the three catecholamines ( cas ) dopamine ( da ) , norepinephrine ( ne ) and epinephrine ( e ) , are wide-spread in tissues of the american eel ( anguilla rostrata ) , the bulk of these cas in the systemic blood originates from chromaffin cells in the wall of the posterior cardinal veins . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
83,
94
]
} |
shortly after ovulation the gth concentration slightly decreased together with a sharp decline in the concentrations of 17alpha,20beta-dihydroxy-4-pregnen-3-one and the 5beta-reduced steroids , with the exception of 5beta-pregnane-3alpha,17alpha,20alpha-triol , 5beta-pregnane-3alpha,6alpha,17alpha,20beta-tetrol and 5beta-dihydrotestosterone . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
183,
191
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
268,
276
]
} |
after selected ion monitoring the following steroids could be detected by the presence of at least two characteristic ions at the expected retention time : 5beta-pregnane-3alpha , 17alpha,20beta-triol , etiocholanolone , 5beta-dihydrotestosterone , 5beta-androstane-3alpha,11beta-diol-17-one , testosterone and estradiol . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
44,
52
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
162,
170
]
} |
after selected ion monitoring the following steroids could be detected by the presence of at least two characteristic ions at the expected retention time : 5beta-pregnane-3alpha , 17alpha,20beta-triol , etiocholanolone , 5beta-dihydrotestosterone , 5beta-androstane-3alpha,11beta-diol-17-one , testosterone and estradiol . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
44,
52
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
255,
265
]
} |
after treatment with beta-glucuronidase the following steroids could be determined in a similar way : 5beta-pregnane-3alpha,17alpha-diol-20-one , 5beta-pregnane-3alpha,17alpha,20alpha-triol , 5beta-pregnane-3alpha,17alpha,20beta-triol , 5beta-pregnane-3alpha,6alpha,17alpha-triol-20-one , 5beta-pregnane,3alpha,6alpha,17alpha,20beta-tetrol , 5beta-androstane-3alpha,17beta-diol , etiocholanolone , 5beta-dihydrotestosterone , testosterone and estradiol . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
54,
62
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
295,
303
]
} |
after treatment with beta-glucuronidase the following steroids could be determined in a similar way : 5beta-pregnane-3alpha,17alpha-diol-20-one , 5beta-pregnane-3alpha,17alpha,20alpha-triol , 5beta-pregnane-3alpha,17alpha,20beta-triol , 5beta-pregnane-3alpha,6alpha,17alpha-triol-20-one , 5beta-pregnane,3alpha,6alpha,17alpha,20beta-tetrol , 5beta-androstane-3alpha,17beta-diol , etiocholanolone , 5beta-dihydrotestosterone , testosterone and estradiol . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
54,
62
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
348,
358
]
} |
the free steroids 5beta-pregnane-3alpha,6alpha,17alpha,20beta-tetrol and 5beta-pregnane-3alpha,6alpha,17alpha-triol-20-one and the steroid glucuronides of testosterone , 5beta-dihydrotestosterone and estradiol appeared to be the most abundant of these compounds . | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
24,
32
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
131,
138
]
} |
the time course of appearance of catecholamine metabolites was studied in the spleen of cod , gadus morhua , during perfusion with radioactively labelled noradrenaline and adrenaline at 10 degrees c . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
154,
167
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
172,
182
]
} |
perfusion with noradrenaline resulted in mainly mopeg , vma and doma formation , while perfusion with adrenaline additionally resulted in mn formation . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
it is concluded from the study that the fate of noradrenaline and adrenaline within the cod spleen depends on their affinities for the two uptake mechanisms and an extraneuronal site of deamination of great importance can not be excluded . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
48,
61
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
66,
76
]
} |
streptomycin-resistant colonies were isolated from protoplast cultures of haploid nicotiana plumbaginifolia based on their ability to green in medium containing 1 mg/ml streptomycin sulfate . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
0,
12
]
} | {
"id": "C0038426",
"name": "streptomycin sulfate",
"pos": [
169,
189
]
} |
seeds from self-fertilized transgenic plants were germinated on media containing toxic levels of cadmium and scored for tolerance/ susceptibility to this heavy metal . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
97,
104
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
154,
165
]
} |
these results suggest that the mt genome found in male-sterile sugar beet may originate not from modifications of the fertile mitochondrial genome but from a particular source of cytoplasm , of which a possible origin is discussed . | NA | {
"id": "C0021364",
"name": "male-sterile",
"pos": [
50,
62
]
} | {
"id": "C0021359",
"name": "not",
"pos": [
88,
91
]
} |
desired goals were : model i = reduced lignin and cellulose , with increased hemicellulose , resulting in no change in cell wall content ; | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
39,
45
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
81,
90
]
} |
both of these two protein loci encode for endosperm proteins and mostly belong to the minor polypeptide subunits of the glutelin fraction of rice seed proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
104,
112
]
} |
leaves of vitreous plants had higher levels of reducing sugars and sucrose but lower or undetectable levels of inositol as compared to normal plants . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
56,
62
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
67,
74
]
} |
treatment differences were observed in the in vitro adventitious shoot regeneration response from internodal explants of three genotypes of populus deltoides cultured on media supplemented with five concentrations each of the cytokinins 6-benzyladenine , 2-isopentyladenine , and zeatin . | NA | {
"id": "C0010815",
"name": "cytokinins",
"pos": [
226,
236
]
} | {
"id": "C0043456",
"name": "zeatin",
"pos": [
280,
286
]
} |
chick embryo fibroblasts ( cef ) containing this insert express subgroup a envelope glycoprotein since they yield focus-forming pseudotype virus when co-cultivated with transformed quail cells expressing envelope-defective bryan high-liter rous sarcoma virus ( rsv ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} |
the isozyme of got-2 and got-3 zones were dimeric and under the control of three alleles at the got-2 locus and two alleles at the got-3 locus , respectively . | NA | {
"id": "C0684153",
"name": "got-2",
"pos": [
15,
20
]
} | {
"id": "C0004002",
"name": "got",
"pos": [
131,
134
]
} |
marker pollen homozygous for a rare idh allele was the genetic marker in each pollen mix . | NA | {
"id": "C0005516",
"name": "marker",
"pos": [
0,
6
]
} | {
"id": "C0017393",
"name": "genetic",
"pos": [
55,
62
]
} |
for 13 enzymes , the existence of high isozyme diversity in both sugar beet gene pools was revealed . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
7,
14
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
39,
46
]
} |
fifty-eight soybean accessions from the genus glycine , subgenus soja , were surveyed with 17 restriction fragment length polymorphism ( rflp ) genetic markers to assess the level of molecular diversity and to evaluate the usefulness of previously identified rflp markers . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
144,
159
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
264,
271
]
} |
a gas chromatograph with a flame photometric detector is set up for the direct analysis of cos , h2s , cs2 , so2 , ch3sh , c2h5sh in ambient air . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
2,
5
]
} | {
"id": "C0038777",
"name": "so2",
"pos": [
109,
112
]
} |
dose-response curves using covalently closed circular plasmid dna , in the absence of carrier dna , have been obtained for each of these reporter genes . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
45,
53
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
94,
97
]
} |
the use of carrier dna ( herring sperm dna ) , in combination with covalently closed circular plasmid dna , increased the level of expression of gus by about 50 % . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
19,
22
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
85,
93
]
} |
these latter changes can not be explained without the action of strong acids originating from anthropogenic air pollution.losses of elements like magnesium , calcium and potassium occur and phosphorus become less available to plants . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
132,
140
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
190,
200
]
} |
high concentrations of mobile anions ( notably sulfate ) are responsible for the negative alkalinity and these solutions on co2 degassing in surface waters can retain acidities equivalent to a ph value of 5.0 or less . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
30,
36
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
47,
54
]
} |
this natural acidification from a mobile no inf3 ( sup- ) ion resulted in an pronounced increase in soil base cation leaching and mobilization of aluminium in the soil profile . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
23,
26
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
110,
116
]
} |
stream so inf4 ( sup2- ) concentrations also were high relative to precipitation inputs suggesting mineralization of sulfur within the ecosystem and/or poor soil adsorption of so inf4 ( sup2- ) . this is an important finding in such ecosystems where cation nutrient ion levels are often very low . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
250,
256
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
266,
269
]
} |
the effect of any increased atmospheric inputs of these ions would be accelerated cation leaching and ecosystem acidification . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
56,
60
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
119,
125
]
} |
crystalline fe hydrous oxides appear more effective than amorphous fe hydrous oxides at adsorbing so 4 ( sup2- ) . high anthropic anion inputs , inability of forest soil to adsorb additional inputs and perhaps so 4 ( sup2- ) desorption appear responsible for the replacement of hco 3 ( sup- ) by so 4 ( sup2- ) in stream water . | NA | {
"id": "C0030015",
"name": "oxides",
"pos": [
23,
29
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
130,
135
]
} |
because below freezing processes relocate any internal impurities to the ice surfaces within the snowpack , the impurities are available to the first melt water . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
73,
76
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
155,
160
]
} |
treatment of maternal phenylketonuria ( pku ) consists of a low phenylalanine diet , begun before conception , which is believed to prevent mental retardation , microcephaly , and congenital heart disease in offspring of women with pku . | NA | {
"id": "C0085547",
"name": "maternal phenylketonuria",
"pos": [
13,
37
]
} | {
"id": "C0031485",
"name": "pku",
"pos": [
232,
235
]
} |
an olfactometer bioassay was used to follow attractant for screwworm flies , cochliomyia hominivorax , in steam distillates of bovine blood under different distillation and storage conditions and after hplc separation of components in a water-methanol gradient . | NA | {
"id": "C0038225",
"name": "steam",
"pos": [
106,
111
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
237,
242
]
} |
investigation of the lipid extract of the australian chrysomelid beetle , monolepta australis , has revealed a novel homologous series of long-chain , unsaturated-saturated dialkyl ethers in the cuticular wax . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
21,
26
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
205,
208
]
} |
the methylenedioxyphenyl-containing ( mdp ) inhibitors of mixed-function oxidase detoxification enzymes , myristicin , safrole , fagaramide , and isosafrole , occur with xanthotoxin or other toxic furanocoumarins in plants of the families umbelliferae and rutaceae . | NA | {
"id": "C0025684",
"name": "xanthotoxin",
"pos": [
170,
181
]
} | {
"id": "C0016859",
"name": "furanocoumarins",
"pos": [
197,
212
]
} |
the suitability of the bradford protein assay for measuring plant protein was evaluated and a standard method developed . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0032089",
"name": "plant protein",
"pos": [
60,
73
]
} |
among 22 amino acids , alanine , arginine , glycine , histidine , isoleucine , leucine , methionine , proline , serine , tryptophan , and valine were active . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
9,
20
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
23,
30
]
} |
among 22 amino acids , alanine , arginine , glycine , histidine , isoleucine , leucine , methionine , proline , serine , tryptophan , and valine were active . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
9,
20
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
44,
51
]
} |
these results suggest that the higher leaf volatile terpene content observed under nitrate limitation apparently results from increased synthesis per leaf and accumulation of mono- and sesquiterpenes in immature leaves of nitratepoor plants . | NA | {
"id": "C0039561",
"name": "terpene",
"pos": [
52,
59
]
} | {
"id": "C0036847",
"name": "sesquiterpenes",
"pos": [
185,
199
]
} |
in their larval luminal midgut fluid , trichoplusia ni ( lepidoptera : noctuidae ) andpieris rapae ( lepidoptera : pieridae ) contain endopeptidases as their primary proteases . | NA | {
"id": "C0030946",
"name": "endopeptidases",
"pos": [
134,
148
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
166,
175
]
} |
hybridization and nucleotide sequence analysis of the dna adjacent to the tl/tr junction shows that no plant dna is located between the tl and tr-dnas and suggests that the plant dna adjacent to the end of the tr-dna may have been rearranged during the integration into the plant genome . | NA | {
"id": "C0242964",
"name": "plant dna",
"pos": [
103,
112
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
213,
216
]
} |
total cellular rna and proteins were used to determine the relative steady-state levels of mrna for ribosomal proteins ( r-proteins ) by dot blot hybridization and the relative amounts of proteins by immunodetection with specific antibodies . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
100,
118
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
188,
196
]
} |
nucleosome-like structures have been efficiently assembled in vitro by interaction of cauliflower histones , pbr322 dna and cauliflower dna topoisomerase , as assayed by supercoiling of relaxed circular dna and by digestion with micrococcal nuclease . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
194,
206
]
} |
the roles of glucose and amp in regulating the conversion of phosphorylase a into phosphorylase b . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
61,
74
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
82,
97
]
} |
smaller molecular weight membrane-bound proteins are preferentially labeled in the crypt cells , whereas on the villus the pattern of labeling is more evenly distributed among the various proteins . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
25,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
188,
196
]
} |
this has been studied within the species of lipoproteins comprising the very low density lipoproteins ( vldl ) which transport the bulk of endogenously formed triglyceride . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
44,
56
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
72,
88
]
} |
blood glucose and free fatty acid ( ffa ) responses to catecholamines in rats treated chronically with noradrenaline or adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
103,
116
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
120,
130
]
} |
the cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials . p-chloromercuribenzene sulfonate and p-chloromercuribenzoate inhibit the binding of steroid by receptors in cell-free extracts , but they allow the steroid-receptor complex to form in whole cells . | NA | {
"id": "C0034809",
"name": "glucocorticoid",
"pos": [
58,
72
]
} | {
"id": "C0034840",
"name": "steroid-receptor",
"pos": [
312,
328
]
} |
lincomycin , or the closely related derivative clindamycin , was used to treat six patients with bacteroides infection . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
0,
10
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
47,
58
]
} |
as folate deficiency may ultimately limit drug metabolism this hypothesis would explain why blood phenytoin levels decrease and fit control may worsen after correction of folate deficiency in epileptic patients . | NA | {
"id": "C0036572",
"name": "fit",
"pos": [
128,
131
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
192,
201
]
} |
luteinizing hormone ( a pituitary gonadotropic hormone ) stimulates delta ( 5 ) -3beta- hydroxysteroid dehydrogenase activity in the microsomal fraction of frog testes when incubated together with the mitochondria ; | NA | {
"id": "C0023607",
"name": "luteinizing hormone",
"pos": [
0,
19
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropic hormone",
"pos": [
24,
54
]
} |
electronegative elements will be detected with similar sensitivities in the spectrum of negative sputtered ions , but inert gases , which are ionized with difficulty and have small electron affinities , will be detected with considerably poorer sensitivities . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
16,
24
]
} | {
"id": "C0017112",
"name": "inert gases",
"pos": [
118,
129
]
} |
when mixtures of the two nontoxic mutant proteins , enzymically active crm ( 45 ) protein and enzymically inactive crm ( 197 ) protein , are subjected to mild treatment with trypsin in the presence of a thiol and then allowed to reoxidize after dialysis to remove excess thiol , `` '' diphtheria toxin '' '' is reconstituted in high yield . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
34,
49
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
127,
134
]
} |
a fluorometric method combined with thin layer chromatography for the determination of norepinephrine , epinephrine and dopamine in human urine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
87,
101
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} |
effect of tuberculin and freund 's adjuvant on the formation of fibroblast colonies by immunocompetent cell populations . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
64,
74
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
103,
107
]
} |
in contrast to norepinephrine , the predominant direct effect of epinephrine on coronary vessels was dilatation mediated through activation of vascular beta receptors . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
15,
29
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} |
although 45 % of the patients with at had respiratory tract disease , there was no correlation found between ige deficiency or combined ige and iga deficiency and respiratory tract disease in these patients.11 of 25 individuals with isolated iga deficiency were also ige deficient . | NA | {
"id": "C0035242",
"name": "respiratory tract",
"pos": [
42,
59
]
} | {
"id": "C0035204",
"name": "respiratory tract disease",
"pos": [
163,
188
]
} |
sucrose density gradient analyses of sera immediately after antigen injections suggested the presence of immune complexes of dna and antibody since both heavy sedimenting and 7s ig were detected . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
105,
121
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
133,
141
]
} |
two of these five patients had significant responses which were compatible with hypopituitarism resulting from damage to the hypothalamus or hypothalamic vessels instead of the pituitary . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
80,
95
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
177,
186
]
} |
the j chains isolated from polymeric iga and igm were shown to be distinct from the other immunoglobulin subunits , including the secretory component , both on the basis of amino-acid content and antigenic determinants . | NA | {
"id": "C0021035",
"name": "j chains",
"pos": [
4,
12
]
} | {
"id": "C1302674",
"name": "immunoglobulin subunits",
"pos": [
90,
113
]
} |
specific antibodies to gross antigens can be detected in the kidney where they have been deposited in the glomeruli , apparently in the form of gross antigen-antibody complexes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
9,
19
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
150,
176
]
} |
micronuclear dna consists of four or more density components and melts as if it were a mixture of several dnas of different base compositions . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
13,
16
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
125,
126
]
} |
the enzyme apparently acts by introducing a single-strand nick into the dna , forming a dna-enzyme complex that allows the strands to rotate relative to the helix axis before reversing the reaction and sealing the break . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
92,
106
]
} |
synthesis and secretion of gammaglobulin by lymph node cells : the acquisition of carbohydrate residues of immunoglobulin in relation to interchain disulfide bond formation ( heavy and light chains-murine myeloma-mannose-glucosamine-galactose ) . | NA | {
"id": "C0017007",
"name": "gammaglobulin",
"pos": [
27,
40
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
107,
121
]
} |
the alkylations caused : ( i ) a decrease in the k ( cat ) values , particularly marked for the carboxymethylated b isoenzyme , ( ii ) a change in the apparent pk of the k ( cat ) curves , and ( iii ) a dependence of k ( m ) on ph , for the alkylated enzymes , in contrast to the ph-independent k ( m ) values of the native enzymes . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
116,
125
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
324,
331
]
} |
polyamine stimulation of nucleic acid synthesis in an uninfected and phage-infected polyamine auxotroph of escherichia coli k12 ( arginine-agmatine ureohydrolase-putrescine-spermidine-lysine-cadaverine ) . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
162,
172
]
} | {
"id": "C0037871",
"name": "cadaverine",
"pos": [
191,
201
]
} |
in mixed cultures with untransformed mouse embryo fibroblasts , their parent strain , however , l cells are able to form colonies above the monolayer of normal fibroblasts , i.e. , they have a property characteristic of transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
50,
61
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
232,
237
]
} |
prostaglandin e 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts ( mouse l cells-tissue culture-enzyme kinetics-prostaglandin homologues ) . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
0,
15
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
173,
186
]
} |
incubation of l-929 and l-2071 fibroblasts with prostaglandin e ( 1 ) ( pge ( 1 ) ) caused a rapid increase in the cyclic amp content of these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
hydrolysis of protein from cells labeled with glutamine , however , yields substantial amounts of glutamic acid in addition to glutamine and pyroglutamic acid . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
98,
111
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
127,
136
]
} |
these data indicate that n-terminal pyroglutamic acid can be derived from glutamic acid without prior conversion of glutamic acid to glutamine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
40,
53
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
133,
142
]
} |
since free or bound forms of glutamine cyclize nonezymatically to pyroglutamate with ease , while glutamic acid does not , the data suggest that n-terminal pyroglutamic acid formation from glutamic acid is enzymatic rather than spontaneous . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
29,
38
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
189,
202
]
} |
a transport form of collagen from embryonic tendon : electron microscopic demonstration of an nh 2 -terminal extension and evidence suggesting the presence of cystine in the molecule ( chick embryo-tropocollagen-gel filtration ) . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
20,
28
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
198,
211
]
} |
when cells were isolated from chickembryo tendons and incubated in vitro for 2-6 hr , essentially all the newly-synthesized collagen was recovered from the incubation medium as a transport form larger than tropocollagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
124,
132
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
206,
219
]
} |
electron microscopy of segment-long-spacing aggregates prepared from the transport form of collagen showed that the native molecule differed from tropocollagen in that it had an extension of about 13 nm ( 130 a ) at the nh ( 2 ) -terminal end . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
91,
99
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
146,
159
]
} |
man-mouse and man-syrian hamster somatic hybrid cell lines were prepared by fusion of mouse a9 or hamster tg2 cells , which are deficient in hypoxanthine-guanine phosphoribosyl transferase , with cells of a diploid fibroblastic strain , kop-1 , derived from a woman heterozygous for an x-autosome translocation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
215,
227
]
} |
the cells composing these nodules , presumably fibroblasts , showed three significant ultrastructural features : ( 1 ) a fibrillar system similar to that of smooth muscle cells ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} |
based on these data and on recent information about the biology of the fibroblasts , it is suggested that these cells are fibroblasts that have modulated into contractile cells ( myofibroblasts ) , and that their contraction plays a role in the pathogenesis of the contracture observed clinically . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
171,
176
]
} |
these data support the hypothesis that plasma lipoproteins , primarily the vldl , when altered in size and composition can coalesce into globules of sufficient size to occlude peripheral capillaries . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
46,
58
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
75,
79
]
} |
a comparison of the effects of acth , cyclic amp , dibutyryl cyclic amp , and pge2 on corticosteroidogenesis in vitro . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
38,
48
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
51,
71
]
} |
effects of 17 beta-estradiol on the incorporation of pyrimidine nucleotide precursors into nucleotide pools and rna in the mouse uterus . | NA | {
"id": "C0034288",
"name": "pyrimidine nucleotide",
"pos": [
53,
74
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
91,
101
]
} |
the proteins of the smooth and rough endoplasmic reticulum from fetal , immature , and adult male rats were compared after incorporation of two radioactively labeled precursors , ( 14 ) c-labeled amino acids and delta-aminolevulinic acid- ( 3 ) h by means of gel electrophoresis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
196,
207
]
} | {
"id": "C0002563",
"name": "delta-aminolevulinic acid",
"pos": [
212,
237
]
} |
production of ( 3 h ) catecholamines in the brain following the peripheal administration of 3 h-dopa during pre- and postnatal development . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
22,
36
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
96,
100
]
} |
the precursor of the kinin-forming enzyme , prekallikrein , was isolated from rabbit plasma protected from activation during preparatory procedures . | NA | {
"id": "C0022478",
"name": "kinin-forming enzyme",
"pos": [
21,
41
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
44,
57
]
} |
addition of polyadenylic-polyuridylic acid in complex form ( poly a : u ) without antigen to a suspension of spleen cells obtained from balb/aj mice primed 6 wk previously with human gamma-globulin ( hgg ) resulted in an immediate fourfold increase over background number of anti-hgg rosette-forming cells ( rfc ) . | NA | {
"id": "C0032402",
"name": "polyadenylic-polyuridylic acid",
"pos": [
12,
42
]
} | {
"id": "C0032400",
"name": "poly a",
"pos": [
61,
67
]
} |
appearance of chemotactic activity for human neutrophils by the conversion of human prekallikrein to kallikrein . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
84,
97
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
101,
111
]
} |
while neither highly purified prekallikrein nor the prealbumin hageman factor fragments were chemotactic alone , their interaction so as to convert prekallikrein to kallikrein yielded both chemotactic and kinin-generating activity . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
30,
43
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
165,
175
]
} |
capillary permeability and blood flow in skeletal muscle of patients with diabetes mellitus and genetic prediabetes . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
74,
91
]
} | {
"id": "C0362046",
"name": "prediabetes",
"pos": [
104,
115
]
} |
a likely suppressor agent is a proline transfer rna with a quadruplet anticodon or its functional equivalent . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
39,
51
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
70,
79
]
} |
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