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comprehensive monitoring over prolonged periods improves diagnosis and management because it ( 1 ) increases the detection of specific electrical epileptiform events , ( 2 ) makes possible the precise characterization of the clinical and electrical seizure activities and their interrelationships , and ( 3 ) provides a method for the quantitation of the epileptic process in the brain before and after treatment .
NA
{ "id": "C0036572", "name": "seizure", "pos": [ 249, 256 ] }
{ "id": "C0014544", "name": "epileptic", "pos": [ 355, 364 ] }
elements relevant to differential diagnosis between epileptic seizure and non-epileptic seizure as a consequence of syncope , cardiac arrhythmia or pseudoepilepsy are reviewed and discussed .
NA
{ "id": "C0014544", "name": "epileptic seizure", "pos": [ 52, 69 ] }
{ "id": "C0036572", "name": "seizure", "pos": [ 88, 95 ] }
our experience with long-term monitoring of closed circuit tv-eeg of 136 medically refractory seizure patients showed that ( a ) about 19 % have pseudoepileptic seizures , ( b ) only 36 % of those verified pseudoepileptic seizure patients had epileptic seizures as well , and ( c ) 77 % of pseudoepileptic seizures mimicked aspects of complex partial seizures .
NA
{ "id": "C0014544", "name": "epileptic seizures", "pos": [ 151, 169 ] }
{ "id": "C0036572", "name": "seizures", "pos": [ 351, 359 ] }
patients commonly suffer from both true and pseudoseizures , therefore it is often necessary for the patient to be seen in a special epilepsy center where anticonvulsants can be slowly withdrawn and both types of seizures documented .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 133, 141 ] }
{ "id": "C0036572", "name": "seizures", "pos": [ 213, 221 ] }
the resulting library of video taped seizures is a valuable resource for teaching and the production of films on epilepsy .
NA
{ "id": "C0036572", "name": "seizures", "pos": [ 37, 45 ] }
{ "id": "C0014544", "name": "epilepsy", "pos": [ 113, 121 ] }
video recording has helped to improve the diagnosis and treatment of seizures and has been widely used in clinical epilepsy research .
NA
{ "id": "C0036572", "name": "seizures", "pos": [ 69, 77 ] }
{ "id": "C0014544", "name": "epilepsy", "pos": [ 115, 123 ] }
use of antisera to follicle-stimulating hormone ( fsh ) to detect non-fsh factors in human serum which modulate rat granulosa cell steroidogenesis .
NA
{ "id": "C0733758", "name": "follicle-stimulating hormone", "pos": [ 19, 47 ] }
{ "id": "C0016774", "name": "fsh", "pos": [ 70, 73 ] }
these antisera completely neutralized the actions of ovine fsh , human fsh , and menopausal gonadotropin ( pergonal ) added to serum .
NA
{ "id": "C0733758", "name": "fsh", "pos": [ 59, 62 ] }
{ "id": "C0016774", "name": "human fsh", "pos": [ 65, 74 ] }
pma caused dose-dependent increments of testosterone formation by leydig cells , whereas inactive phorbol esters had no significant effects .
NA
{ "id": "C0039654", "name": "pma", "pos": [ 0, 3 ] }
{ "id": "C0031586", "name": "phorbol esters", "pos": [ 98, 112 ] }
somatostatin-14 and somatostatin-28 pretreatment down-regulate somatostatin-14 receptors and have biphasic effects on forskolin-stimulated cyclic adenosine , 3',5'-monophosphate synthesis and adrenocorticotropin secretion in mouse anterior pituitary tumor cells .
NA
{ "id": "C0037659", "name": "somatostatin-14", "pos": [ 0, 15 ] }
{ "id": "C0074854", "name": "somatostatin-28", "pos": [ 20, 35 ] }
activation of somatostatin-14 ( s-14 ) receptors on mouse att-20 pituitary tumor cells by s-14 or somatostatin-28 ( s-28 ) inhibits forskolin-stimulated camp synthesis and acth secretion .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 32, 36 ] }
{ "id": "C0074854", "name": "somatostatin-28", "pos": [ 98, 113 ] }
in this study , the effects of prolonged exposure of cells to s-14 or s-28 was found to reduce , in a time- and concentration-dependent fashion , the density of s-14 receptors without affecting the affinity of these sites for [ 125i ] tyr11-s-14 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 70, 74 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 241, 245 ] }
additionally , s-14 and s-28 pretreatment also resulted in a time-dependent sensitizing effect on forskolin-stimulated camp formation and acth secretion which preceded s-14 receptor down-regulation .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 15, 19 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 24, 28 ] }
the enhancing effect of s-14 and s-28 required new protein synthesis , since it was partially blocked by cycloheximide ;
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 24, 28 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 33, 37 ] }
both the enhanced and depressed forskolin responses after peptide pretreatment were reversible after withdrawal of s-14 or s-28 ;
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 115, 119 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 123, 127 ] }
the data suggest that s-14 receptor down-regulation is not causally associated with the sensitizing effects of s-14 and s-28 on adenylate cyclase and that the s-14 receptor may be also coupled to other effector systems which are involved in regulating the secretory function of att-20 cells .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 22, 26 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 120, 124 ] }
relationship between receptor binding and biopotency of somatostatin-14 and somatostatin-28 in mouse pituitary tumor cells .
NA
{ "id": "C0037659", "name": "somatostatin-14", "pos": [ 56, 71 ] }
{ "id": "C0074854", "name": "somatostatin-28", "pos": [ 76, 91 ] }
membrane receptors for s-14 characterized using [ 125i-tyr11 ] s-14 as the radioligand [ maximum binding capacity ( bmax ) = 1.28 +/- 0.1 pmol/mg ; dissociation constant ( kd ) = 1.1 +/- 0.04 nm ] bound s-28 with 3-fold greater affinity than s-14 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 203, 207 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 242, 246 ] }
binding sites quantitated using an s-28 analog [ leu8 , d-trp22 , 125i-tyr25 ] s-28 as radioligand ( bmax = 1.18 +/- 0.15 pmol/mg ; kd = 0.08 +/- 0.06 nm ) also exhibited greater affinity for s-28 than s-14 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 35, 39 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 202, 206 ] }
preincubation of the cells with s-14 and s-28 ( 10 ( -7 ) m ) resulted in a marked decrease ( 36 % and 71 % , respectively ) of s-14 receptor concentration .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 32, 36 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 41, 45 ] }
coincubation of the cells with both s-14 and s-28 led to 56 % decrease in s-14 receptor binding .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 36, 40 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 45, 49 ] }
the responsiveness of the cells to forskolin stimulation of acth secretion and camp accumulation was significantly enhanced by preincubation with s-14 ( 10 ( -7 ) m ) whereas the responsiveness to forskolin was completely abolished by preincubation with s-28 .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 146, 150 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 254, 258 ] }
simultaneous exposure of the cells to both s-14 and s-28 resulted in a partial reversal of the inhibiting effect of s-28 on forskolin-stimulated camp accumulation in these cells but did not result in a partial reversal of the inhibitory effect of s-28 on forskolin-stimulated acth secretion in these cells .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 43, 47 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 247, 251 ] }
the differential effects of these peptides after preincubation on the responsiveness of acth secretion and camp accumulation in these cells to forskolin stimulation suggests the possibility of existence of distinct s-14 and s-28 receptors , but these could not be identified by direct binding experiments using the s-14 and s-28 analogs employed in the study as radioligands .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 215, 219 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 324, 328 ] }
scatchard analysis [ dissociation constant ( kd ) , 0.5 +/- 0.02 ( se ) nm ] , binding specificity , and diethylaminoethyl chromatography of these [ 3h ] estradiol binding sites are similar to those described for estrogen receptors .
NA
{ "id": "C0034803", "name": "estradiol binding sites", "pos": [ 154, 177 ] }
{ "id": "C0034804", "name": "estrogen receptors", "pos": [ 213, 231 ] }
hepatic metabolism of somatostatin-14 and somatostatin-28 : immunochemical characterization of the metabolic fragments and comparison of cleavage sites .
NA
{ "id": "C0037659", "name": "somatostatin-14", "pos": [ 22, 37 ] }
{ "id": "C0074854", "name": "somatostatin-28", "pos": [ 42, 57 ] }
in the present study we have characterized the hepatic metabolism of somatostatin-28 ( s-28 ) and compared it with that of s-14 to determine whether s-28 is degraded by a process similar to that for s-14 , and additionally , whether the hepatic metabolism of s-28 results in significant conversion to s-14 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 87, 91 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 301, 305 ] }
isolated rat livers were perfused with synthetic s-28 , somatostatin-25 [ ( s-25 ) , an n-terminal metabolite of s-28 ] , c- and n-terminally radioiodinated analogs of s-28 , s-14 , and des-ala1-s-14 [ ( s-13 ) , an n-terminal metabolite of s-14 ] .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 49, 53 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 241, 245 ] }
the metabolic products were characterized by separate n-terminally directed s-14 and s-28 rias , a common ring-directed ria for s-14 , s-28 , s-13 , and s-25 , immunoprecipitation , gel chromatography , and hplc .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 76, 80 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 135, 139 ] }
hepatic extractions of s-28 and s-25 , monitored as ring-directed immunoreactivity , were equivalent , but both occurred 4 times more slowly than that of s-14 or s-13 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 23, 27 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 154, 158 ] }
by contrast , the n-terminal metabolism of s-14 and s-28 monitored by specific n-terminal rias occurred at similar rates ( hepatic extraction of 54 % and 44 % , respectively ) .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 43, 47 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 52, 56 ] }
both s-14 and s-28 were degraded significantly more rapidly at the n-terminus than at the ring segment .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 5, 9 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 14, 18 ] }
gel chromatography of s-28 perfusates followed by ria of the column fractions for n-terminal and ring-reactive metabolites , showed a time-dependent conversion of s-28 to a peak coeluting with s-14 ( 27 % conversion by 60 min ) .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 22, 26 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 193, 197 ] }
that s-14 was a significant metabolite of s-28 was further confirmed by hplc analysis of the hepatic perfusate .
NA
{ "id": "C0037659", "name": "s-14", "pos": [ 5, 9 ] }
{ "id": "C0074854", "name": "s-28", "pos": [ 42, 46 ] }
these data have demonstrated that the hepatic metabolism of s-28 occurs via three separate processes , two of which are similar to those for s-14 .
NA
{ "id": "C0074854", "name": "s-28", "pos": [ 60, 64 ] }
{ "id": "C0037659", "name": "s-14", "pos": [ 141, 145 ] }
sixty-one percent had known someone who had epilepsy , and 52 % had seen someone having a seizure .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 44, 52 ] }
{ "id": "C0036572", "name": "seizure", "pos": [ 90, 97 ] }
when those familiar with epilepsy were asked if they would object to having their children in school or at play associate with persons with seizures , only 11 % replied they would object .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 25, 33 ] }
{ "id": "C0036572", "name": "seizures", "pos": [ 140, 148 ] }
approximately 25 % of patients with epilepsy will have their first seizure after the age of 25 years .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 36, 44 ] }
{ "id": "C0036572", "name": "seizure", "pos": [ 67, 74 ] }
because seizures are a symptom and not a disease , it is often difficult to distinguish epileptic seizures from alcohol-withdrawal seizures .
NA
{ "id": "C0036572", "name": "seizures", "pos": [ 8, 16 ] }
{ "id": "C0014544", "name": "epileptic seizures", "pos": [ 88, 106 ] }
furthermore , the hypothesis drawn from the neuropathological observations to explain the etiopathogenesis of this category of epilepsy and the physiopathogenesis of the seizures does not seem acceptable to the authors .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 127, 135 ] }
{ "id": "C0036572", "name": "seizures", "pos": [ 170, 178 ] }
first , cdna sequences detected with one monoclonal antibody cross-hybridized with those identified by the other antibody .
NA
{ "id": "C0003250", "name": "monoclonal antibody", "pos": [ 41, 60 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 113, 121 ] }
human adenovirus early region 1a ( e1a ) gene products differentially regulate the expression of early region 2a ( e2a ) encoding the dna-binding protein ( dbp ) .
NA
{ "id": "C0033684", "name": "gene products", "pos": [ 41, 54 ] }
{ "id": "C0012940", "name": "dna-binding protein", "pos": [ 134, 153 ] }
the results obtained indicate that the product encoded by the e1a 13s mrna is responsible for the stimulation of dbp produced from the early promoter and that the 12s mrna codes for the product which represses the synthesis of dbp from the late promoter .
NA
{ "id": "C0033684", "name": "dbp", "pos": [ 113, 116 ] }
{ "id": "C0012940", "name": "dbp", "pos": [ 227, 230 ] }
at-rich dna , which constitutes a distinct fraction of the cellular dna of the archaebacterium methanococcus voltae , was shown to consist of non-repetitive sequences dispersed on the chromosome and to lack continuous open reading frames in five out of six randomly analyzed cases .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 8, 11 ] }
{ "id": "C0000702", "name": "a", "pos": [ 276, 277 ] }
the two drosophila isoacceptors are identical besides containing either a guanosine ( g ) or the hypermodified nucleoside queuosine ( q ) in the wobble position .
NA
{ "id": "C0018330", "name": "guanosine", "pos": [ 74, 83 ] }
{ "id": "C0028619", "name": "queuosine", "pos": [ 122, 131 ] }
labelling of cultured cells with [ 3h ] palmitic and [ 3h ] myristic acids demonstrates that each of these fatty acids modifies a substantially different subset of cellular proteins .
NA
{ "id": "C0027139", "name": "myristic acids", "pos": [ 60, 74 ] }
{ "id": "C0015684", "name": "fatty acids", "pos": [ 107, 118 ] }
in contrast to fibroblasts , a431 cells respond to epidermal growth factor ( egf ) with a decreased growth rate .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 15, 26 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 34, 39 ] }
ribosomal dna sequences are at least 20-fold enriched in topoisomerase/dna complexes isolated directly from a chromosomal setting , relative to total dna .
NA
{ "id": "C0012933", "name": "ribosomal dna", "pos": [ 0, 13 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 150, 153 ] }
in lepidopteran insect cells infected with the baculovirus autographa californica nuclear polyhedrosis virus ( acnpv ) , two major late viral gene products are expressed : the polyhedrin , a 28 000 mol . wt . protein which makes up the mass of the nuclear inclusion bodies , and a 10 000 mol . wt . protein ( p10 ) whose function is unknown .
NA
{ "id": "C0042736", "name": "viral gene", "pos": [ 136, 146 ] }
{ "id": "C0033684", "name": "protein", "pos": [ 299, 306 ] }
immune serum to crude clostridium difficile toxin and non-immune serum were coated onto polystyrene microtiter plates to act as capture antibodies ;
NA
{ "id": "C0020960", "name": "immune serum", "pos": [ 0, 12 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 136, 146 ] }
this and other data suggest that sensitive and resistant cells may internalize exotoxin a in a similar manner , the toxin entering the cytosol from a prelysosomal acidic vacuole .
NA
{ "id": "C0015309", "name": "exotoxin", "pos": [ 79, 87 ] }
{ "id": "C0040549", "name": "toxin", "pos": [ 116, 121 ] }
attempts to demonstrate cross-serotype protection using o-antigen-deficient and core-deficient pseudomonas aeruginosa lipopolysaccharide antigens was , for the most part , unsuccessful .
NA
{ "id": "C0069180", "name": "o-antigen", "pos": [ 56, 65 ] }
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 118, 136 ] }
a protein of large molecular mass ( estimated molecular mass : 312 +/- 41 kda , mean +/- sd , n = 8 ) could be immunoprecipitated from the cells at all chase periods between 5 min and 60 min with both monoclonal antibodies to a narrow density cut of the low density lipoprotein ldl-2 ( density : 1.030-1.055 g/ml ) and polyclonal antibodies to the apolipoprotein b apo b 100 or to a narrow density cut of ldl-2 ( density : 1.030-1.055 g/ml ) .
NA
{ "id": "C0205666", "name": "apolipoprotein b", "pos": [ 348, 364 ] }
{ "id": "C0003593", "name": "b apo", "pos": [ 363, 368 ] }
staining with antibody to these thrombin-reactive proteins and 125i-protein a showed several reactive plasma proteins under nondenaturing conditions with the major band migrating in the albumin area .
NA
{ "id": "C0033684", "name": "proteins", "pos": [ 50, 58 ] }
{ "id": "C0001924", "name": "albumin", "pos": [ 186, 193 ] }
proteins linked to the whole rrna , to 5s rna and to 28-5.8 s rnas were identified by two-dimensional gel electrophoresis after rna hydrolysis by ribonucleases t1 and a .
NA
{ "id": "C0035701", "name": "rrna", "pos": [ 29, 33 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 128, 131 ] }
our results showed that numerous proteins interact with rrnas ( at least ten with 28-5.8 s rna , eight with 5s rna and among these three are common to both ) and have been discussed in the light of all the available data .
NA
{ "id": "C0035701", "name": "rrnas", "pos": [ 56, 61 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 111, 114 ] }
comparison with albumin 125i-microaggregates clearance of human serum albumin failed to demonstrate that they can be used for this purpose .
NA
{ "id": "C0001924", "name": "albumin", "pos": [ 16, 23 ] }
{ "id": "C0304925", "name": "human serum albumin", "pos": [ 58, 77 ] }
the distribution of two monoclonal antibodies with reactivity against human leukemia/lymphoma associated antigens ( ba-1 antibody ) and carcinoembryonic antigen ( 202 antibody ) when labeled with 131i or 111in was studied in normal balb/c mice .
NA
{ "id": "C0003250", "name": "monoclonal antibodies", "pos": [ 24, 45 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 167, 175 ] }
the data indicate that the relative distribution of 131i-labeled versus 111in-labeled monoclonal antibody may depend on the immunoglobulin subclass of the antibody and the molar ratio used in labeling .
NA
{ "id": "C0003250", "name": "monoclonal antibody", "pos": [ 86, 105 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 155, 163 ] }
small bleeding vessels in the hematoma cavity can be coagulated using a 1.5 mm neodym yag laser microprobe introduced through the endoscope under visual control .
NA
{ "id": "C0019080", "name": "bleeding", "pos": [ 6, 14 ] }
{ "id": "C0018944", "name": "hematoma", "pos": [ 30, 38 ] }
the mca rm124 ( igm ) strongly binds to bnml cells as measured by fluorescence intensity of a second-layer antibody ( goat anti-mouse igm fluorescein isothiocyanate ) .
NA
{ "id": "C0003250", "name": "mca", "pos": [ 4, 7 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 107, 115 ] }
the relationship between menstrual cycle patterns and the risk of breast disease was evaluated using data from a hospital-based case-control study of 288 women with benign breast disease ( 203 chronic cystic diseases and 85 benign tumours ) , 317 with breast cancer and 602 age-matched controls with a spectrum of acute conditions unrelated to any of the established or potential risk factors for breast disease .
NA
{ "id": "C0006145", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C0016034", "name": "benign breast disease", "pos": [ 165, 186 ] }
from this study , it appears that the ratio of low-grade malignant nhl in japan is much lower than in the western countries .
NA
{ "id": "C0079747", "name": "low-grade malignant nhl", "pos": [ 47, 70 ] }
{ "id": "C0024305", "name": "nhl", "pos": [ 67, 70 ] }
vascular structure of the c3h mammary carcinoma , the b16 melanoma and the lewis lung carcinoma in syngeneic , conventional mice and congenitally athymic mice .
NA
{ "id": "C0007097", "name": "carcinoma", "pos": [ 38, 47 ] }
{ "id": "C0243038", "name": "lewis", "pos": [ 75, 80 ] }
methylprednisolone hemisuccinate ( mps ) and methylprednisolone ( mp ) concentrations in plasma and urine were monitored in renal transplant and glomerulonephritis patients who were given i.v . infusions of 0.5 g or 1 g of mps .
NA
{ "id": "C0025819", "name": "methylprednisolone hemisuccinate", "pos": [ 0, 32 ] }
{ "id": "C0025815", "name": "methylprednisolone", "pos": [ 45, 63 ] }
evidence is presented that monoclonal antibodies ( mab ) against some human major histocompatibility complex ( mhc ) gene products and human sera containing hla antibodies strongly inhibit immune phagocytosis of anti-d-sensitized red blood cells by human monocytes .
NA
{ "id": "C0003250", "name": "monoclonal antibodies", "pos": [ 27, 48 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 161, 171 ] }
definite inhibition was also apparent with a mab against drw52/mt2 ( i-lr2 ) and with an antibody to class ii antigens of high cell surface density ( 2mc3 ) .
NA
{ "id": "C0003250", "name": "mab", "pos": [ 45, 48 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 89, 97 ] }
the salvage of purine bases ( adenine , hypoxanthine and guanine ) was active in both m phi populations , whereas purine biosynthesis de novo was low .
NA
{ "id": "C0001407", "name": "adenine", "pos": [ 30, 37 ] }
{ "id": "C0034140", "name": "purine", "pos": [ 114, 120 ] }
purine nucleosides ( inosine , guanosine and adenosine ) were efficiently degraded to uric acid and only adenosine was directly salvaged into nucleotides .
NA
{ "id": "C0034136", "name": "purine nucleosides", "pos": [ 0, 18 ] }
{ "id": "C0021528", "name": "inosine", "pos": [ 21, 28 ] }
purine nucleosides ( inosine , guanosine and adenosine ) were efficiently degraded to uric acid and only adenosine was directly salvaged into nucleotides .
NA
{ "id": "C0034136", "name": "purine nucleosides", "pos": [ 0, 18 ] }
{ "id": "C0018330", "name": "guanosine", "pos": [ 31, 40 ] }
purine nucleosides ( inosine , guanosine and adenosine ) were efficiently degraded to uric acid and only adenosine was directly salvaged into nucleotides .
NA
{ "id": "C0034136", "name": "purine nucleosides", "pos": [ 0, 18 ] }
{ "id": "C0001443", "name": "adenosine", "pos": [ 105, 114 ] }
highly purified peripheral blood resting t cells were obtained by sequentially using three procedures ( adherence to plastic surface , adherence to nylon wool columns and treatment with four monoclonal antibodies against antigens on ac and activated t cells plus complement ) .
NA
{ "id": "C0032167", "name": "plastic", "pos": [ 117, 124 ] }
{ "id": "C0028736", "name": "nylon", "pos": [ 148, 153 ] }
the jurkat model was used to study the nature of accessory cell because this cell line does not show any reactivity to allogeneic cells .
NA
{ "id": "C0007634", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C3485979", "name": "allogeneic cells", "pos": [ 119, 135 ] }
this p150/95 antigen is the third member of a family of polypeptides sharing a common 95-kda beta chain , which includes the lymphocyte function-associated antigen lfa-1 ( p177/95 ) and complement receptor cr3 ( mo1/mac-1/okm1 ; p165/95 ) antigens .
NA
{ "id": "C0034793", "name": "complement receptor", "pos": [ 186, 205 ] }
{ "id": "C0079785", "name": "mac-1", "pos": [ 216, 221 ] }
in the control group , following a 4 min lag period ventricular arrhythmias as single ectopic beats , ventricular tachycardia and ventricular fibrillation ( vf ) appeared , reaching a maximum between 10 and 20 min and disappearing after 30 min .
NA
{ "id": "C0003811", "name": "arrhythmias", "pos": [ 64, 75 ] }
{ "id": "C0042510", "name": "ventricular", "pos": [ 130, 141 ] }
mortality ( 40 % in the control group ) coincided with the period of maximal arrhythmias , with vf more common in animals that died than in those surviving .
NA
{ "id": "C0003811", "name": "arrhythmias", "pos": [ 77, 88 ] }
{ "id": "C0042510", "name": "vf", "pos": [ 96, 98 ] }
motor stimulation induced by amphetamine or the amantadine analog memantine was reduced while that of apomorphine was enhanced by the long-term amantadine treatment .
NA
{ "id": "C0025242", "name": "memantine", "pos": [ 66, 75 ] }
{ "id": "C0002403", "name": "amantadine", "pos": [ 144, 154 ] }
to elucidate the heterogeneity of human fibroblasts from lung and skin , the effects of hydrocortisone on cell proliferation and the specific dexamethasone binding to cells were studied .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 40, 51 ] }
{ "id": "C0007634", "name": "the", "pos": [ 129, 132 ] }
these studies indicate that ( a ) the cbd activity of pfn , and not its heparan sulfate-binding activity , is the critical determinant in neurite extension of these neural tumor cells from the central nervous system ;
NA
{ "id": "C2266866", "name": "cbd activity", "pos": [ 38, 50 ] }
{ "id": "C2917226", "name": "heparan", "pos": [ 72, 79 ] }
morphology and distribution of cell-substrate contacts and their association with microfilament bundles in normal and rsv-transformed quail fibroblasts ( 16q line ) were studied by indirect immunofluorescence .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 31, 35 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 140, 151 ] }
in contrast , the ecm produced by fibroblasts ( fecm ) readily supported the attachment and flattening of ewing 's sarcoma cells but had only a small effect on the carcinoma cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 34, 45 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 174, 179 ] }
this effect has been mimicked by the addition of glutaraldehyde-fixed human fibroblasts to sparsely seeded growing cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 76, 87 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 115, 120 ] }
formation of stress fibres and focal adhesion sites in monensin-exposed cultured human fibroblasts in response to exogenously added cellular fibronectin .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 87, 98 ] }
{ "id": "C0007634", "name": "cellular", "pos": [ 132, 140 ] }
icb contained 200-300 fmol ( mg protein ) -1 alpha 2-adrenoreceptors which represents approximately two-thirds of the total number of alpha-adrenoreceptor sites present in this tissue .
NA
{ "id": "C0001639", "name": "alpha", "pos": [ 45, 50 ] }
{ "id": "C0034784", "name": "alpha-adrenoreceptor", "pos": [ 134, 154 ] }
the level of cellular contamination during separation of pe by non-pigmented epithelial ( npe ) cells was estimated to be 5-10 % and by non-epithelial cells ( i.e . endothelial , fibroblasts and blood cells ) less than 1 % .
NA
{ "id": "C0007634", "name": "cellular", "pos": [ 13, 21 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 179, 190 ] }
various kinds of cell-types such as squamous epithelial cells , columnar epithelial cells , sarcomatous cells and fibroblast-like cells proliferated in vitro during the initial period of the primary culture from the human benign gastric tridermal teratoma .
NA
{ "id": "C0007634", "name": "cells", "pos": [ 56, 61 ] }
{ "id": "C0016030", "name": "fibroblast", "pos": [ 114, 124 ] }
a free energy diagram for the potential reactions of feo2 visualizes myoglobin as a molecular structure that can provide in solution the delicate balance of kinetic and thermodynamic factors necessary to stabilize reversible oxygenation , as opposed to irreversible autoxidation to metmyoglobin .
NA
{ "id": "C0027078", "name": "myoglobin", "pos": [ 69, 78 ] }
{ "id": "C0025852", "name": "metmyoglobin", "pos": [ 282, 294 ] }
in particular , the effect of calmodulin on these transport enzymes is mimicked by partial proteolysis and antibodies against erythrocyte ca2+-transport atpase also bind to the smooth muscle ( ca2+ + mg2+ ) atpase .
NA
{ "id": "C0001476", "name": "ca2", "pos": [ 138, 141 ] }
{ "id": "C0001473", "name": "atpase", "pos": [ 207, 213 ] }
use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin , oxytocin and ddavp in rats after prolonged infusion of ddavp .
NA
{ "id": "C0032017", "name": "neurohypophysial hormone", "pos": [ 53, 77 ] }
{ "id": "C0030095", "name": "oxytocin", "pos": [ 129, 137 ] }
blood chemistry of heteropneustes fossilis exposed to sewage , fertilizers and insecticides showed signs of anemia , dehydration and disturbance in the pituitary-interrenal endocrine axis and the excretory function of gills .
NA
{ "id": "C0014130", "name": "disturbance", "pos": [ 133, 144 ] }
{ "id": "C0032002", "name": "pituitary", "pos": [ 152, 161 ] }
a comparison of the bacteriostatic substance produced by s. epidermidis isolate 66 with the bactericidal substance produced by s. haemolyticus isolate 7 , which had been previously purified , showed that they were similar lipoproteins or lipid-associated proteins .
NA
{ "id": "C0023820", "name": "lipoproteins", "pos": [ 222, 234 ] }
{ "id": "C0023779", "name": "lipid", "pos": [ 238, 243 ] }
we found that , at 1/2 mic , ampicillin , cefoxitin and penicillin g decreased adherence of gonococci by more than 65 % , and erythromycin by approximately 40 % ;
NA
{ "id": "C0002680", "name": "ampicillin", "pos": [ 29, 39 ] }
{ "id": "C0030827", "name": "penicillin g", "pos": [ 56, 68 ] }
aminoglycoside nephrotoxicity was produced in two groups of fischer rats by intraperitoneal injection of gentamicin , 40 mg/kg/day for 2 weeks .
NA
{ "id": "C0002556", "name": "aminoglycoside", "pos": [ 0, 14 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 105, 115 ] }
the ultrastructure of the submandibular acinar cells was not affected by the conditioned cf fibroblast culture medium .
NA
{ "id": "C0007634", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C0016030", "name": "fibroblast", "pos": [ 92, 102 ] }
when the granulomas reached maximum size after 10 to 12 weeks , the plasminogen activator with 45k and 24k diminished , while plasminogen activator activity at mr = 95k , 74k , and 60k remained unchanged suggesting the presence of both vascular and tissue types of plasminogen activators .
NA
{ "id": "C0032144", "name": "plasminogen", "pos": [ 68, 79 ] }
{ "id": "C0032143", "name": "tissue types", "pos": [ 249, 261 ] }
based on the assumption that amino acid residues which are critical for function are preferentially conserved , we predict from the sequence that glycine residue 15 rather than residue 12 is important for ( pyro ) phosphate binding .
NA
{ "id": "C0002520", "name": "amino", "pos": [ 29, 34 ] }
{ "id": "C0017890", "name": "glycine", "pos": [ 146, 153 ] }
polyclonal antisera against prostaglandins ( pgs ) are widely used for the assessment of the biological role of these mediators , but even the most specific contain antibodies against the major metabolites and degradation products of the haptens employed .
NA
{ "id": "C0020960", "name": "antisera", "pos": [ 11, 19 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 165, 175 ] }
when confluent cultures of the transformed human keratinocyte line sv-k14 are shifted to serum-free medium the cells achieve , within 4 days , the ability to synthesize a cornified envelope after challenge with the ca2+ ionophore a23187 .
NA
{ "id": "C0022567", "name": "line", "pos": [ 62, 66 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 111, 116 ] }
according to our convulsion intensity scoring system , these animals have an audiogenic response score ( ars ) of 3 and the colony is designated the gepr-3 colony .
NA
{ "id": "C0036572", "name": "convulsion", "pos": [ 17, 27 ] }
{ "id": "C0014544", "name": "gepr", "pos": [ 149, 153 ] }
thus , these epilepsy-prone animals are no more likely to experience convulsions in response to overdose of one of these three drugs than are nonepileptic subjects .
NA
{ "id": "C0014544", "name": "epilepsy", "pos": [ 13, 21 ] }
{ "id": "C0036572", "name": "convulsions", "pos": [ 69, 80 ] }