text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the plasma 15n-glycine and 15n-alanine isotope-enrichment time-decay curves over the first hour following a single i.v . dose of 15-amino acid represent mostly the hepatic uptake of glycine and alanine from the extracellular pool . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
132,
137
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
194,
201
]
} |
in the face of fixed basal levels of insulin ( 9 microunits/ml ) and glucagon ( 63 pg/ml ) maintained by the infusion of somatostatin and replacement amounts of the two pancreatic hormones , the mean arterial plasma glucose concentration was elevated from 102 to 217 mg/dl by continuous glucose infusion . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
121,
133
]
} | {
"id": "C0030292",
"name": "pancreatic hormones",
"pos": [
169,
188
]
} |
evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
36,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
61,
68
]
} |
somatostatin at a concentration of 10 micrograms/ml inhibited 300 mg/dl glucose-stimulated proinsulin synthesis by 25 % from 448 +/- 25 dpm/microunits insulin to 336 +/- 25 dpm/microunits insulin ( disintegrations per minute in the proinsulin peak per microunit extractable insulin ) ( p less than 0.05 ) . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
91,
101
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
274,
281
]
} |
a previously proposed hypothesis that magnesium could enter the cells only at erythropoiesis and then decay monoexponentially predicted a half-life of 22.4 days and is therefore seen to be an oversimplification of magnesium kinetics in the red cell . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
138,
147
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
224,
232
]
} |
although not consistent in all instances , the change of diet also resulted in an enhanced formation of both cholic acid and chenodeoxycholic acid and a higher contribution of deoxycholic acid in duodenal bile . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
125,
146
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
176,
192
]
} |
the use of therapeutic agents to correct the predominant defect should provide the most effective means of controlling the hyperglycemia and glucose intolerance of the individual patient . | NA | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
123,
136
]
} | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
141,
160
]
} |
we are presently evaluating the long-term effects of the sulfonylurea glipizide on a group of patients with insulin-independent diabetes . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
57,
69
]
} | {
"id": "C0017642",
"name": "glipizide",
"pos": [
70,
79
]
} |
however , glipizide , in distinction from those sulfonylureas that have been examined previously , also causes a long-term increase in glucose-stimulated insulin secretion . | NA | {
"id": "C0017642",
"name": "glipizide",
"pos": [
10,
19
]
} | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
48,
61
]
} |
preparation , characterization , and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin , fmn , and fad . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
108,
118
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
121,
124
]
} |
the genes for the small and large ribosomal subunit rnas were mapped by gel transfer hybridization of in vitro labelled rrna to restriction fragments of mitochondrial dna and its cloned eco r i fragment e3 , and by electron microscopy of rna/dna hybrids . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
120,
124
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
238,
241
]
} |
five cases of leprosy , four borderline tuberculoid and one indeterminate , which were recently diagnosed in indo-chinese refugees in adelaide are reported . | NA | {
"id": "C0023343",
"name": "leprosy",
"pos": [
14,
21
]
} | {
"id": "C1562908",
"name": "borderline tuberculoid",
"pos": [
29,
51
]
} |
the various coefficients of serum concentrations of total cholesterol , triglycerides , phospholipids , hdl-cholesterol , ldl-cholesterol , and the ratio hdl-cholesterol/total cholesterol and ldl/hdl ( socalled atherosclerosis-index ) were estimated . | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
104,
119
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
176,
187
]
} |
the various coefficients of serum concentrations of total cholesterol , triglycerides , phospholipids , hdl-cholesterol , ldl-cholesterol , and the ratio hdl-cholesterol/total cholesterol and ldl/hdl ( socalled atherosclerosis-index ) were estimated . | NA | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
122,
137
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
176,
187
]
} |
poly ( a ) -containing rna was obtained by poly ( u ) -sepharose chromatography and shown to be virtually free of rrna and its average size was 13-15 s . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
23,
26
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
114,
118
]
} |
drug therapy mainly consists of nicotinic acid and its derivates , clofibrinic acid and its derivates as well as clofibrate successors . | NA | {
"id": "C0009003",
"name": "clofibrinic acid",
"pos": [
67,
83
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
113,
123
]
} |
1-fluoro-2,4-dinitrobenzene ( fdnb ) , an electrophilic agent , which is used to identify terminal amino acids in proteins ( sanger reagent ) , readily reacts with gsh leading to a dose-dependent depletion of bacterial gsh . | NA | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
13,
27
]
} | {
"id": "C0012463",
"name": "sanger reagent",
"pos": [
125,
139
]
} |
outcomes from cardiac arrest due to underlying heart disease were determined during two periods : two years with standard care by emergency medical technicians and one year with defibrillator-trained technicians . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
14,
28
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
47,
60
]
} |
the protein responsible for malignant transformation by avian sarcoma viruses ( asvs ) has been identified as a phosphoprotein of molecular weight 60,000 designated pp60src ( refs 1 -- 4 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
112,
126
]
} |
while attempting to locate the cell bodies of the enkephalin containing neurones present in hippocampus using ka injections , we found that a few days after intracerebral injections of ka a drastic increase in the met-enkephalin ( me ) content of hippocampus occurs . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
50,
60
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
214,
228
]
} |
intracranial injection of angiotensin ii ( aii ) or activation of the cerebral isorenin-angiotensin system with intracranial renin causes an immediate thirst and a delayed sodium appetite in the rat . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
26,
40
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
88,
99
]
} |
rat monoclonal antibodies were raised to the akr mouse t lymphoma kkt-2 , and these antibodies were screened independently for blockade of virus-binding and for cytostatic activity on kkt-2 cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
84,
94
]
} |
in both areas , the rate of release of dopamine was higher than the rates of release of noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
88,
101
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} |
electrical stimulation of the splanchnic nerve elicited a rise in the arterial blood pressure and increased the rates of release of noradrenaline , adrenaline and dopamine in the anterior hypothalamic area . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
132,
145
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
148,
158
]
} |
ependymal cells adjacent to the neostriatum contained lipofuscin and osmiophilic lipid at 6 months but by 12 months the latter had become much less osmiophilic . | NA | {
"id": "C0023789",
"name": "lipofuscin",
"pos": [
54,
64
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
81,
86
]
} |
haemorrhoid cryosurgery in 528 cases operated since the university of genoa colon and rectum diseases centre opened is illustrated . | NA | {
"id": "C0019112",
"name": "haemorrhoid",
"pos": [
0,
11
]
} | {
"id": "C0034882",
"name": "rectum diseases",
"pos": [
86,
101
]
} |
[ relationships between mycoplasma and vaginitis . experimental clinical study of 400 cases of vaginal diseases treated with the combination of amphotericin b and tetracycline ] . | NA | {
"id": "C0042267",
"name": "vaginitis",
"pos": [
39,
48
]
} | {
"id": "C0042251",
"name": "vaginal diseases",
"pos": [
95,
111
]
} |
in pregnancy anaerobic prevalence falls progressively from the first to the third trimester and increases precipitously immediately after delivery . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
3,
12
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
76,
91
]
} |
this study was designed to focus upon within-culture differences in plasma lipids and lipoproteins in venezuelan schoolchildren having different socioeconomic and nutritional backgrounds and also to provide cross-cultural comparisons of lipids , lipoproteins , and anthropometric measurements between venezuelan and american schoolchildren . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
75,
81
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
246,
258
]
} |
both guanosine triphosphate and guanylyl-imidodiphosphate ( gmp-pnp ) significantly enhance epinephrine-stimulated adenylyl cyclase activity at all fetal and postnatal ages . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
5,
27
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
60,
67
]
} |
with increasing age , the absolute guanosine triphosphate or gmp-pnp activated rate rises in parallel with the basal rate of adenylyl cyclase activity in the rat heart . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
35,
57
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
61,
68
]
} |
the metabolism of [ 3h ] -25-hydroxyvitamin d3 ( 3h-25-oh-d3 ) to [ 3h ] -1,25-dihydroxyvitamin d3 ( 3h-1,25- ( oh ) 2d ) 3 and [ 3h ] 24 , 325 dihydroxyvitamin d3 ( 3h-24,25- ( oh ) 2d3 ) was studied in sheep fetuses and lambs . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
26,
46
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
52,
60
]
} |
in a randomized , prospective , double-blind study infants and children with uncomplicated salmonella gastroenteritis were treated with ampicillin ( 15 patients ) , amoxicillin ( 15 patients ) , or placebo ( 14 patients ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
136,
146
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
165,
176
]
} |
bacteriologic relapse was not observed in placebo-treated patients but eight patients given ampicillin ( 53 % ) and eight given amoxicillin ( 53 % ) had relapse ( p = .003 ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
128,
139
]
} |
it is concluded that ampicillin or amoxicillin therapy provides no benefit to patients with uncomplicated salmonella gastroenteritis and substantially increases the risk of bacteriologic and symptomatic relapse . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
21,
31
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
35,
46
]
} |
amino acid contents of the dsbm and excreta for all except the sulfur amino acids were determined after acid hydrolysis . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0002527",
"name": "sulfur",
"pos": [
63,
69
]
} |
glycine and arginine were the least and most efficiently digested amino acids with values of 80 % and 93 % , respectively . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
66,
77
]
} |
fluorometry was applied to the study of the content of a number of amines ( dopa ) , adrenalin , noradrenaline ) in the adrenal glands and various structures of the rat brain in endogenous deficiency of melanocyte-stimulating hormone of the hypophysis caused by parenteral administration of synthetic melanostatin ( mif ) of the hypothalamus . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
85,
94
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
97,
110
]
} |
comparison of the molecular structure and crystal packing with those of free biotin suggests that the coenzyme may have evolved with the incorporation of the ureido moiety because the electronic configuration of this region of the molecule is sensitive to n1 ' carboxylation . | NA | {
"id": "C0005575",
"name": "biotin",
"pos": [
77,
83
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
102,
110
]
} |
the cooh-terminal amino acid is heterogenous in that analyses of the cooh-terminal peptides isolated from different ef-tu preparations gave position 393 as glycine and serine in ratios ( gly/ser ) ranging from about 0.7 to 3 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
18,
28
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
187,
190
]
} |
in the recombinant plasmid employed , viral dna sequences specifying the large species of polyoma tumor antigen but not the small and middle tumor antigens were interrupted by the insertion of plasmid dna at the ecori restriction endonuclease site . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
104,
111
]
} | {
"id": "C0003335",
"name": "tumor antigens",
"pos": [
141,
155
]
} |
the label appears entirely in glycoproteins with approximately 90 % in the major variable surface coat glycoprotein ( vscg ) . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
30,
43
]
} | {
"id": "C0025248",
"name": "surface",
"pos": [
90,
97
]
} |
the uptake rates of both specifically incorporated ( vitellogenin ) and nonspecifically incorporated proteins ( bovine serum albumin and x. laevis serum proteins lacking albumin ) were not influenced by the method of labeling . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
101,
109
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
170,
177
]
} |
thus , after a 3-hr incubation , 3-5 times more ( 125 ) i-labeled bovine serum albumin and x. laevis serum proteins lacking albumin were degraded than the corresponding ( 3 ) h-labeled proteins ( 95 % compared to 30 % and 75 % compared to 15 % , respectively ) , whereas after a 24-hr incubation , the degradation of ( 125 ) i-labeled vitellogenin was 15 times greater than that of [ ( 3 ) h ] vitellogenin labeled in vivo ( 60 % compared to 4 % ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
79,
86
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
185,
193
]
} |
taxol inhibited the migration behavior of fibroblast cells , but these cells did not lose their ability to produce mobile surface projections such as lamellipodia and filopodia . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
42,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} |
t ( a ) ( + ) and t ( a ) ( - ) cells respond equally well to soluble antigens , allogeneic b cells , and autologous b cells , but only t ( a ) ( + ) cells respond to concanavalin a . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
81,
91
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
thus , neither antigen nor histocompatibility , but antigen-unspecific factor ( s ) for growth and ig secretion are required to stimulate a b-cell blast through the next round of division . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
15,
22
]
} | {
"id": "C0003316",
"name": "antigen",
"pos": [
52,
59
]
} |
the other peptide contains both [ leu ] enkephalin and [ met ] enkephalin sequences and is presumably a common precursor of the two forms of enkephalin . | NA | {
"id": "C0014294",
"name": "leu ] enkephalin",
"pos": [
34,
50
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
141,
151
]
} |
the other peptide contains both [ leu ] enkephalin and [ met ] enkephalin sequences and is presumably a common precursor of the two forms of enkephalin . | NA | {
"id": "C0014295",
"name": "met ] enkephalin",
"pos": [
57,
73
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
141,
151
]
} |
from these `` '' cancer equivalent '' '' doses the number of single-strand dna breaks required to produce the spontaneous cancers is estimated to be 0.26-1.3 per cell dna per day . | NA | {
"id": "C0012935",
"name": "f single-strand d",
"pos": [
59,
76
]
} | {
"id": "C0012854",
"name": "d",
"pos": [
41,
42
]
} |
the viral dna was cleaved with restriction endonuclease hindiii and inserted in the unique hindiii site of lambda charon 21a dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
4,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
125,
128
]
} |
the small amount of nucleic acid homology previously reported between the hbv and whv dnas could be demonstrated between the cloned viral dnas . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
20,
32
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
138,
142
]
} |
the small amount of nucleic acid homology previously reported between the hbv and whv dnas could be demonstrated between the cloned viral dnas . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
86,
90
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
132,
137
]
} |
we propose that this rna is the recognition component of the nuclear rna splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
21,
24
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
61,
72
]
} |
in vitro protein synthesis directed by pox7dna yielded the mr 42,000 precursor of the leucine-specific binding protein and a small amount of the mr 39,000 mature protein . | NA | {
"id": "C0033665",
"name": "precursor",
"pos": [
69,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
162,
169
]
} |
comparisons with other viral rnas , based on oligonucleotide mapping and molecular hybridization , indicated that 4.5-kb fsv rna contains a 5 ' gag gene-related sequence of 1 kb , an internal specific sequence of about 3 kb that is unrelated to rous sarcoma virus , mc29 , and erythroblastosis virus , and a 3'-terminal sequence of about 0.5 kb related to the conserved c region of avian tumor viruses . | NA | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
23,
33
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
187,
190
]
} |
in order to account for the exceptionally high proton-hydroxyl permeability with respect to other monovalent ions , we propose that protons or hydroxyls or both interact with clusters of hydrogen-bonded water molecules in the lipid bilayer , such that they are transferred across the bilayer by rearrangement of hydrogen bonds in a manner similar to their transport in water and ice . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
203,
208
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
379,
382
]
} |
in double-antibody coprecipitation tests , purified iodinated actins from bovine cardiac muscle , rabbit skeletal muscle , chicken embryo brain , and bovine brain all bound to antiserum against chicken embryo brain actin . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
10,
18
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
176,
185
]
} |
the rna can be partially removed by rnase a and totally removed by rnase h . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
36,
41
]
} | {
"id": "C0085431",
"name": "rnase h",
"pos": [
67,
74
]
} |
the gene transfer was resistant to dnase i and therefore seems not to occur via free dna but most likely via uptake of whole bacteria , followed by release of plasmid dna and generation of infectious circular simian virus 40 dna in a recombination-excision process . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
35,
38
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
200,
208
]
} |
this dna segment overlaps a larger region of dna ( 40 kilobase pairs ) previously identified to be around the leu2 locus on chromosome iii [ chinault , a.c. & carbon , j . ( 1979 ) gene 5 , 111-126 ] and physically establishes the directionality of the cloned dna sequences with respect to the genetic map and the centromere . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
260,
263
]
} |
five peptides derived from pro-corticotropin/endorphin ( pro-acth/endorphin ) , the pituitary corticotroph cell prohormone , were bioassayed with isolated rat adrenocortical cells : alpha- and beta-melanotropin , beta-lipotropin , beta-endorphin , and the amino-terminal region of pro-acth/endorphin known as `` '' 16k fragment . '' '' | NA | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
213,
228
]
} | {
"id": "C0033195",
"name": "pro-acth/endorphin",
"pos": [
281,
299
]
} |
although desalivates consumed as much ethanol as controls , their blood ethanol concentrations at all times tested were slightly lower than controls . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
66,
94
]
} |
in the first study , serotonin ( 5-ht ) levels were increased by administration of 5-hydroxy-l-tryptophan ( 5-htp ) and ro4-4602 , a decarboxylase inhibitor , to cats that had overlearned the dr . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
95,
105
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
108,
113
]
} |
the thyroid accumulation , metabolism and urine excretion of ( 35s ) propylthiouracil was compared in the guinea pig and the rat . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
27,
37
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
48,
57
]
} |
we have analysed the distribution of each of the nine virus-specified proteins between the nucleus and cytoplasm of virus-infected cells , and find that in addition of the np and the ns1 proteins , two of the three p proteins show preferential migration into the nucleus . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
54,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
217,
225
]
} |
preliminary evidence suggests that the molecular basis of host range and virulence may be related to the rna segments coding for one of the polymerase proteins ( p3 ) and for the nucleoprotein ( np ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
151,
159
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
179,
192
]
} |
with glucose alone , freeze-dried hemoglobin has generally a better stability than the four albumin containing preparations in the different assays ( methemoglobin and oxyhemoglobin levels , hill number , shape of the barcroft 's curve ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
34,
44
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
150,
163
]
} |
at present experiments are being carried out on animals with vaccines prepared with antigenically related heterologous cornavirus species , not pathogenic for the host , and with subunitary vaccines prepared from the projections of the homologous species . | NA | {
"id": "C0042210",
"name": "vaccines",
"pos": [
61,
69
]
} | {
"id": "C0887892",
"name": "subunitary vaccines",
"pos": [
179,
198
]
} |
activation of 125i-factor ix and 125i-factor x : effect of tissue factor and factor vii , factor xa and thrombin . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
38,
46
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
90,
99
]
} |
two fatal cases of mixed connective tissue disease ( mctd ) terminating as progressive systemic sclerosis are described clinically , serologically and pathologically . | NA | {
"id": "C0009782",
"name": "of",
"pos": [
16,
18
]
} | {
"id": "C0036421",
"name": "progressive systemic sclerosis",
"pos": [
75,
105
]
} |
obesity-associated insulin resistance is probably due to a decrease in number of insulin receptors , induced by hyperinsulinemia . | NA | {
"id": "C0021655",
"name": "insulin",
"pos": [
19,
26
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
112,
128
]
} |
during fasting there is an inappropriate fall in blood glucose in relation to the course of the plasma insulin concentration , resulting in an increased insulin-glucose ratio . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
46,
62
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
161,
168
]
} |
the data from literature about the meningeal leukemia of acute granulocytic leukemias , the expected long survival of acute promyelocytic leukemias lead to think that this meningeal complication must be systematically prevented . | NA | {
"id": "C0023467",
"name": "acute granulocytic leukemias",
"pos": [
57,
85
]
} | {
"id": "C0023487",
"name": "acute promyelocytic leukemias",
"pos": [
118,
147
]
} |
we evaluated the effect of three platelet inhibitory drugs : acetylsalicylic acid ( asa ) , dipyridamole ( dpm ) , sulphinpyrazone ( spz ) , and a combination of asa plus dpm on platelet adherence to woven dacron in an artificial circulation . | NA | {
"id": "C0004057",
"name": "acetylsalicylic acid",
"pos": [
61,
81
]
} | {
"id": "C0732279",
"name": "asa",
"pos": [
162,
165
]
} |
[ alcohol and drug intoxication during a strike in the state monopoly for liquer and wine sale ] . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
2,
9
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
85,
89
]
} |
lh stimulates the conversion of progesterone and 17 alpha-oh progesterone to androstenedione , testosterone and dht in theca . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
32,
44
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
49,
51
]
} |
in addition to increasing the amount of progesterone receptor , and to a lesser extent estrogen receptor that may be detected , elicidation of the mechanism by which this salt stabilized receptors should contribute to further understanding of how cytosol steroid receptor content and function is regulated . | NA | {
"id": "C0034833",
"name": "progesterone receptor",
"pos": [
40,
61
]
} | {
"id": "C0034840",
"name": "steroid receptor",
"pos": [
255,
271
]
} |
in addition to increasing the amount of progesterone receptor , and to a lesser extent estrogen receptor that may be detected , elicidation of the mechanism by which this salt stabilized receptors should contribute to further understanding of how cytosol steroid receptor content and function is regulated . | NA | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
87,
104
]
} | {
"id": "C0034840",
"name": "steroid receptor",
"pos": [
255,
271
]
} |
conversion of chenodeoxycholic acid to a delta-lactone quassinoid analog and generation of a-ring diosphenol acetate derivatives of deoxycholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
14,
35
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
132,
148
]
} |
specific staining was performed for the isoenzymes of the following three enzymes : alanine aminotransferase ( alat ) , peptidase 1 ( pep ) and malate dehydrogenase ( me ) ( decarboxylating ) ( nadp ) . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
40,
50
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
74,
81
]
} |
selective mitochondrial alterations induced by a single dose of daunorubicin or 4-demethoxydaunorubicin in mouse ventricular myocardium . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
64,
76
]
} | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
80,
103
]
} |
the ventricular myocardium of cd1 mice given a single high dose ( ld50 ) of daunorubicin ( dnr ) or its derivative , 4-demethoxydaunorubicin ( 4dd ) , was studied under the electron microscope . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
76,
88
]
} | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
117,
140
]
} |
furthermore , the nucleolar segregation phenomenon , already described in experimental doxorubicin myocardiopathy , was not observed in the myocardial samples taken 1 and 3 h after dnr or 4dd injection : this fact may be interpreted , without excluding a possible dna-mediated toxic mechanism , as the result of different kinetic behaviour of dnr and 4dd compared to doxorubicin . | NA | {
"id": "C0011015",
"name": "dnr",
"pos": [
181,
184
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
367,
378
]
} |
in the early postoperative period a transient increase of c3c , c4 and factor b was recorded , then complement levels progressively decreased . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
71,
79
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
100,
110
]
} |
the paper deals with capacity of tissues of the bull and rat auricle and of the rat deferent duct for trapping l- [ 3h ] noradrenaline and [ 3h ] adrenaline under different conditions of cooling . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
121,
134
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
146,
156
]
} |
it is established that at the preliminary incubation temperature of 20 degrees c the intensity of tissues trapping both the hormone and mediator is essentially decreased and [ 3h ] noradrenaline does not inhibit the adrenaline trapping . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
181,
194
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
216,
226
]
} |
freezing down to -20 and 196 degrees c has a pronounced inhibitory effect on the [ 3h ] adrenaline and [ 3h ] noradrenaline trapping by all the tissues under study . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} |
the extruded carbamide concentrate increases the content of membrane proteins in the nuclear and mitochondria fractions of bull calf rumen mucosa and changes the spectrum of soluble proteins of these subfractions . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
60,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
182,
190
]
} |
corticosterone added in doses of 10 ( -5 ) and 10 ( -6 ) g/ml significantly decreases vadp and rc in the hippocamp homogenates and has no effect in these concentrations on the respiration rate of cerebral homogenates , which may evidence for a higher sensitivity of the hippocamp tissue to corticosteroid hormones . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
290,
304
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
305,
313
]
} |
to determine whether tetanus toxoid given during pregnancy increases the risk of haemolytic disease of the new-born , 818 group o pregnant women were given one to three doses of tetanus toxoid during the third trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
49,
58
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
204,
219
]
} |
perhaps of greater importance , study of these remote effects of neoplasia may shed light on the nature of the neoplastic process itself . | NA | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
65,
74
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
111,
129
]
} |
19 patients were treated with valproic acid ( vpr ) in combination with classical anticonvulsants ( phenytoin , phenobarbitone , primidone , carbamazepine ) . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
112,
126
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
129,
138
]
} |
this investigation shows that in severe cases of epilepsy treated by combined therapy all given anticonvulsants must reach therapeutic levels to achieve effective control of seizures in most patients . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
49,
57
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
174,
182
]
} |
if adequately prepared ( moro ) , the carrot soup can replace enteral loss of sodium and potassium and contains sufficient glucose and sucrose as free sugars to ensure optimum sodium and water absorption in the jejunum . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
135,
142
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
151,
157
]
} |
each is transcribed into plus-stranded rna which has two functions : to serve as messenger rna for the synthesis of the ten reovirus `` '' primary '' '' proteins , and to serve as template for the synthesis of minus-strands with which they remain associated , thereby giving rise to progeny double-stranded rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
39,
42
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
81,
94
]
} |
identification of viral genotype by rna gel electrophoresis and mapping of oligonucleotides of viral rna has already facilitated epidemiologic investigations . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
36,
39
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
95,
104
]
} |
lambdamycin is a yellow-green pigment antibiotic of the chromoglycoside type with antimicrobial , antiviral , cancerostatic , and ergotropic activity in vitro and in vivo . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
82,
95
]
} | {
"id": "C0003451",
"name": "antiviral",
"pos": [
98,
107
]
} |
pythium aphanidermatum , rhizoctonia bataticola ( syn . = macrophomina phaseolina ) , botryodiplodia theobromae , and two strains of sclerotium rolfsii readily utilized for growth the monosaccharides glucose , fructose and mannose , the disaccharides sucrose and maltose and the polysaccharides dextrin and starch . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
237,
250
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
251,
258
]
} |
pythium aphanidermatum , rhizoctonia bataticola ( syn . = macrophomina phaseolina ) , botryodiplodia theobromae , and two strains of sclerotium rolfsii readily utilized for growth the monosaccharides glucose , fructose and mannose , the disaccharides sucrose and maltose and the polysaccharides dextrin and starch . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
237,
250
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
263,
270
]
} |
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