pmid int64 152 38.9M | mesh_terms stringlengths 14 1.3k | mesh_terms_ui_list listlengths 1 47 ⌀ | title stringlengths 0 1.06k | abstract stringlengths 1 94.7k | index float64 37 15.3M ⌀ | in_total_pubmed bool 2
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36,475,546 | D000369:Aged, 80 and over; D006801:Humans; D005260:Female; D008297:Male; D000072657:ST Elevation Myocardial Infarction; D000088642:Nonagenarians; D012189:Retrospective Studies; D017052:Hospital Mortality; D062645:Percutaneous Coronary Intervention; D006761:Hospitals | [
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"D017052",
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"D006761"
] | In-hospital outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention. | BACKGROUND
The aim of the present analysis was to evaluate the incidence and predictors of in-hospital adverse outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI).
METHODS
Consecutive nonagenarian patients undergoing pPC... | null | false | In-hospital outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention. BACKGROUND
The aim of the present analysis was to evaluate the incidence and predictors of in-hospital adverse outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segmen... |
727,717 | D001157:Arterial Occlusive Diseases; D001158:Arteries; D001160:Arterioles; D001921:Brain; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin; D013116:Spinal Cord; D013577:Syndrome | [
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"D001158",
"D001160",
"D001921",
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"D008875",
"D012867",
"D013116",
"D013577"
] | Papulosis atrophicans maligna (Köhlmeier-Degos disease): a disseminated occlusive vasculopathy. | Malignant atrophic papulosis usually presents as pathognomonic skin lesions followed by acute abdominal pain, bowel perforation, peritonitis, and death. Rare patients who may lack gastrointestinal symptoms present with central nervous system manifestations, including headache, paresthesias, weakness, and rapid deterior... | 10,075,269 | true | Papulosis atrophicans maligna (Köhlmeier-Degos disease): a disseminated occlusive vasculopathy. Malignant atrophic papulosis usually presents as pathognomonic skin lesions followed by acute abdominal pain, bowel perforation, peritonitis, and death. Rare patients who may lack gastrointestinal symptoms present with centr... |
33,835,396 | D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D015897:Comorbidity; D006333:Heart Failure; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists; D013318:Stroke Volume | [
"D000319",
"D057911",
"D015897",
"D006333",
"D006801",
"D000451",
"D013318"
] | Update on the Impact of Comorbidities on the Efficacy and Safety of Heart Failure Medications. | Multiple newer medications benefit patients with heart failure with reduced ejection fraction (HFrEF). While these therapies benefit the broad population with HFrEF, the efficacy and safety of these therapies have been less well characterized in patients with significant comorbidities.
Common comorbidities of high i... | null | false | Update on the Impact of Comorbidities on the Efficacy and Safety of Heart Failure Medications. Multiple newer medications benefit patients with heart failure with reduced ejection fraction (HFrEF). While these therapies benefit the broad population with HFrEF, the efficacy and safety of these therapies have been less w... |
3,425,367 | D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D004243:Divorce; D005260:Female; D006801:Humans; D006814:Hungary; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders; D012307:Risk Factors; D013405:Suicide; D013406:Suicide, Attempted | [
"D000328",
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"D000428",
"D004243",
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"D006814",
"D006973",
"D008297",
"D008875",
"D009497",
"D012307",
"D013405",
"D013406"
] | Neurotics at risk and suicidal behaviour in the Hungarian population. | On the basis of a study of 5,871 persons representative of the Hungarian population over the age of 20 by age, sex, place of residence and occupation, an analysis was made of the relationships between neurosis risk, suicidal behaviour, drinking habits and social and lifestyle characteristics. Measured by the Juhász Neu... | 3,817,374 | true | Neurotics at risk and suicidal behaviour in the Hungarian population. On the basis of a study of 5,871 persons representative of the Hungarian population over the age of 20 by age, sex, place of residence and occupation, an analysis was made of the relationships between neurosis risk, suicidal behaviour, drinking habit... |
29,897,569 | D015502:Absorptiometry, Photon; D001012:Aorta, Abdominal; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D009426:Netherlands; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke; D0660... | [
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"D009203",
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"D016016",
"D012189",
"D012307",
"D020521",
"D066027",
"D061205"
] | A high abdominal aortic calcification score by dual X-ray absorptiometry is associated with cardiovascular events after kidney transplantation. | Aortic calcification is associated with an increased risk for cardiovascular events in renal transplant recipients. This study focused on the association of abdominal aortic calcification (AAC) and cardiovascular events assessed using a dual-energy X-ray absorptiometry (DXA) scoring methodology for AAC.
From 2008 to... | null | false | A high abdominal aortic calcification score by dual X-ray absorptiometry is associated with cardiovascular events after kidney transplantation. Aortic calcification is associated with an increased risk for cardiovascular events in renal transplant recipients. This study focused on the association of abdominal aortic ca... |
7,354,369 | D000377:Agnosia; D001933:Brain Stem; D002544:Cerebral Infarction; D006225:Hand; D006801:Humans; D008526:Medulla Oblongata; D009133:Muscular Atrophy; D011149:Pons; D013577:Syndrome; D014110:Touch; D014715:Vertebrobasilar Insufficiency | [
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"D009133",
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"D013577",
"D014110",
"D014715"
] | Studies on asterognosis and amyotrophy of the hand in brainstem syndromes. Relation to the symptomatology of tumours at the spinocranial junction. | Fifteen patients with symptoms of an ischaemic lesion in the vertebrobasilar territory were investigated with respect to the presence of asterognosis and amyotrophy of the hand muscles. Stereognostic disturbances were noted in 4 patients with a medullary lesion and in two patients with brainstem syndromes of less defin... | 10,317,108 | true | Studies on asterognosis and amyotrophy of the hand in brainstem syndromes. Relation to the symptomatology of tumours at the spinocranial junction. Fifteen patients with symptoms of an ischaemic lesion in the vertebrobasilar territory were investigated with respect to the presence of asterognosis and amyotrophy of the h... |
30,516,639 | D001921:Brain; D019468:Disease Management; D006801:Humans; D033162:Incidental Findings; D002532:Intracranial Aneurysm; D008279:Magnetic Resonance Imaging; D011788:Quality of Life; D012307:Risk Factors | [
"D001921",
"D019468",
"D006801",
"D033162",
"D002532",
"D008279",
"D011788",
"D012307"
] | Management of patients with unruptured intracranial aneurysms. | Intracranial aneurysms are frequent incidental findings on cranial imaging. The decision for preventive treatment depends on the presumed risk of rupture, the efficacy and risk of complications of preventive treatment, and the quality of life having to live with an unruptured aneurysms. Data on all these factors are st... | null | false | Management of patients with unruptured intracranial aneurysms. Intracranial aneurysms are frequent incidental findings on cranial imaging. The decision for preventive treatment depends on the presumed risk of rupture, the efficacy and risk of complications of preventive treatment, and the quality of life having to live... |
28,411,357 | D000328:Adult; D000783:Aneurysm; D001926:Brain Death; D003928:Diabetic Nephropathies; D046148:Donor Selection; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012077:Renal Artery; D014019:Tissue Donors; D016896:Treatment Outcome; D014656:Vascular ... | [
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"D009392",
"D012077",
"D014019",
"D016896",
"D014656"
] | Kidney Transplant From a Deceased Donor With Renal Artery Aneurysm: A Case Report. | The use of marginal kidneys or kidneys with pathologic problems (such as renal artery aneurysms in a living or deceased donor) is on the rise due to organ shortages and improvements in surgical techniques. When renal vascular abnormalities are detected during a transplant, it puts the surgeon in a difficult position to... | 1,414,558 | true | Kidney Transplant From a Deceased Donor With Renal Artery Aneurysm: A Case Report. The use of marginal kidneys or kidneys with pathologic problems (such as renal artery aneurysms in a living or deceased donor) is on the rise due to organ shortages and improvements in surgical techniques. When renal vascular abnormaliti... |
27,852,274 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D004522:Educational Status; D005260:Female; D005783:Gender Identity; D054624:Health Status Disparities; D006801:Humans; D006973:Hypertension; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D01... | [
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"D008875",
"D044469",
"D012737",
"D012959",
"D055815"
] | Educational inequalities in hypertension: complex patterns in intersections with gender and race in Brazil. | Hypertension is a major public health issue worldwide, but knowledge is scarce about its patterns and its relationship to multiple axes of social disadvantages in Latin American countries. This study describes the educational inequality in the prevalence of hypertension in Brazil, including a joint stratification by ge... | null | false | Educational inequalities in hypertension: complex patterns in intersections with gender and race in Brazil. Hypertension is a major public health issue worldwide, but knowledge is scarce about its patterns and its relationship to multiple axes of social disadvantages in Latin American countries. This study describes th... |
9,431,629 | D000368:Aged; D006801:Humans; D007383:Intermittent Claudication; D016015:Logistic Models; D008159:Lumbar Vertebrae; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D013117:Spinal Cord Compression; D013130:Spinal Stenosis | [
"D000368",
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"D007383",
"D016015",
"D008159",
"D008875",
"D011446",
"D011859",
"D013117",
"D013130"
] | A prospective and consecutive study of surgically treated lumbar spinal stenosis. Part I: Clinical features related to radiographic findings. | METHODS
A prospective study of consecutive patients undergoing surgery for central lumbar spinal stenosis.
OBJECTIVE
To evaluate symptoms and signs in patients undergoing surgery for central spinal stenosis and to correlate the findings to age, preoperative duration of symptoms, and radiographically detected constric... | null | false | A prospective and consecutive study of surgically treated lumbar spinal stenosis. Part I: Clinical features related to radiographic findings. METHODS
A prospective study of consecutive patients undergoing surgery for central lumbar spinal stenosis.
OBJECTIVE
To evaluate symptoms and signs in patients undergoing surge... |
552,727 | D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D004322:Drainage; D005260:Female; D010493:Pericarditis; D010496:Pericardium; D013492:Suppuration | [
"D000818",
"D002417",
"D002418",
"D004322",
"D005260",
"D010493",
"D010496",
"D013492"
] | Suppurative pericarditis treated by pericardiotomy in a cow. | The successful treatment of a single case of traumatic reticulopericarditis is described. Under general anaesthesia the pericardial sac was approached by resection of the distal part of the fifth rib and allowed to drain directly to the exterior. The discussion reviews the surgical technique. | 8,748,395 | true | Suppurative pericarditis treated by pericardiotomy in a cow. The successful treatment of a single case of traumatic reticulopericarditis is described. Under general anaesthesia the pericardial sac was approached by resection of the distal part of the fifth rib and allowed to drain directly to the exterior. The discussi... |
18,507,271 | D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension; D007407:Interviews as Topic; D008297:Male; D008568:Memory; D008875:Middle Aged; D009657:North Carol... | [
"D000328",
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"D001794",
"D003071",
"D003430",
"D005260",
"D006801",
"D006973",
"D007407",
"D008297",
"D008568",
"D008875",
"D009657",
"D011581",
"D012044"
] | Blood pressure and memory in older African Americans. | The rates of high blood pressure among African Americans, as a group, are the highest in the world. The implications for higher average blood pressure include complications for many major chronic conditions, such as cardiovascular disease and diabetes. Less well studied is the effect of blood pressure on the cognitive ... | 96,763 | true | Blood pressure and memory in older African Americans. The rates of high blood pressure among African Americans, as a group, are the highest in the world. The implications for higher average blood pressure include complications for many major chronic conditions, such as cardiovascular disease and diabetes. Less well stu... |
9,362,266 | D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction; D017202:Myocardial Ischemia; D009206:Myocardium; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine; D015091:beta-Alanine | [
"D000818",
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"D009203",
"D017202",
"D009206",
"D051381",
"D017208",
"D013654",
"D015091"
] | Taurine depletion, a novel mechanism for cardioprotection from regional ischemia. | Three processes that have been implicated in ischemic injury are impaired Ca2+ movement, altered osmoregulation, and membrane remodeling. Because the amino acid, taurine, affects all three processes, it seemed logical that changes in the myocardial content of taurine might affect ischemic injury. To test this hypothesi... | 8,058,468 | true | Taurine depletion, a novel mechanism for cardioprotection from regional ischemia. Three processes that have been implicated in ischemic injury are impaired Ca2+ movement, altered osmoregulation, and membrane remodeling. Because the amino acid, taurine, affects all three processes, it seemed logical that changes in the ... |
10,203,398 | D001049:Apnea; D001530:Belgium; D016009:Chi-Square Distribution; D003142:Communication; D004632:Emergency Medical Services; D004634:Emergency Medical Technicians; D006323:Heart Arrest; D006801:Humans; D008020:Life Support Care; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors | [
"D001049",
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"D006323",
"D006801",
"D008020",
"D011446",
"D015996",
"D013997"
] | Do victims of an out-of-hospital cardiac arrest benefit from a training program for emergency medical dispatchers? | In this paper, we assessed the effects of a training course for emergency medical dispatchers on the handling of out-of-hospital cardiac arrest cases in the dispatch center of a two-tiered emergency medical services system. A total of 112 cardiac arrest cases were studied; 64 before and 48 after the training course. Be... | 10,901,718 | true | Do victims of an out-of-hospital cardiac arrest benefit from a training program for emergency medical dispatchers? In this paper, we assessed the effects of a training course for emergency medical dispatchers on the handling of out-of-hospital cardiac arrest cases in the dispatch center of a two-tiered emergency medica... |
26,976,877 | D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization; D000077144:Clopidogrel; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D008297:Male; D006278:Medicare; D009203:Myocardial Infarction; D009204:Myocardial Revascularization; D0103... | [
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"D012017",
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"D012307",
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"D016896",
"D014481"
] | Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization. | BACKGROUND
While use of P2Y12 receptor inhibitor is recommended by guidelines, few studies have examined its effectiveness among older non-ST-segment elevation myocardial infarction patients who did not undergo coronary revascularization.
RESULTS
We included unrevascularized non-ST-segment elevation myocardial infarc... | null | false | Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization. BACKGROUND
While use of P2Y12 receptor inhibitor is recommended by guidelines, few studies have examined its effectiven... |
21,558,772 | D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002710:Chlorhexidine; D003428:Cross Infection; D004311:Double-Blind Method; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D... | [
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"D053717",
"D012121",
"D018709",
"D013997"
] | Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery. | OBJECTIVE
To evaluate the effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children undergoing cardiac surgery.
METHODS
Prospective, randomized, double-blind, placebo-controlled trial.
METHODS
Pediatric intensive care uni... | null | false | Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery. OBJECTIVE
To evaluate the effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia and ventilator-associated pneumonia (VAP) in children un... |
15,256,222 | D000818:Animals; D000975:Antioxidants; D001204:Ascorbate Oxidase; D001205:Ascorbic Acid; D001921:Brain; D002851:Chromatography, High Pressure Liquid; D003683:Dehydroascorbic Acid; D005609:Free Radicals; D005978:Glutathione; D006605:Hibernation; D010084:Oxidation-Reduction; D010100:Oxygen; D015427:Reperfusion Injury; D0... | [
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"D013997",
"D014018",
"D014527"
] | Ascorbate distribution during hibernation is independent of ascorbate redox state. | Distribution of ascorbate into tissues is an essential process in ascorbate antioxidant defense. Hibernating animals are studied as a model of tolerance to ischemia-reperfusion because of their tolerance to fluctuations in blood flow associated with prolonged torpor and periodic arousal episodes. Throughout hibernation... | 6,155,104 | true | Ascorbate distribution during hibernation is independent of ascorbate redox state. Distribution of ascorbate into tissues is an essential process in ascorbate antioxidant defense. Hibernating animals are studied as a model of tolerance to ischemia-reperfusion because of their tolerance to fluctuations in blood flow ass... |
25,306,428 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System; D006801:Humans; D008297:Male; D0... | [
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] | Prognostic value of automatically detected early repolarization. | Early repolarization associated with sudden cardiac death is based on the presence of >1-mm J-point elevations in inferior and/or lateral leads with horizontal and/or downsloping ST segments. Automated electrocardiographic readings of early repolarization (AER) obtained in clinical practice, in contrast, are defined by... | 13,353,812 | true | Prognostic value of automatically detected early repolarization. Early repolarization associated with sudden cardiac death is based on the presence of >1-mm J-point elevations in inferior and/or lateral leads with horizontal and/or downsloping ST segments. Automated electrocardiographic readings of early repolarization... |
12,670,851 | D003951:Diagnostic Errors; D004636:Emergency Service, Hospital; D006801:Humans; D008297:Male; D008505:Medical Staff, Hospital; D008875:Middle Aged; D009203:Myocardial Infarction; D016584:Panic Disorder; D010346:Patient Care Management; D010360:Patient Transfer; D011787:Quality of Health Care; D012017:Referral and Consu... | [
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"D011787",
"D012017",
"D012449"
] | Profiles in patient safety: emergency care transitions. | A 59-year-old man presented to the emergency department (ED) with the chief complaint of "panic attacks." In total, he was evaluated by 14 faculty physicians, 2 fellows, and 16 residents from emergency medicine, cardiology, neurology, psychiatry, and internal medicine. These multiple transitions were responsible, in pa... | 9,367,473 | true | Profiles in patient safety: emergency care transitions. A 59-year-old man presented to the emergency department (ED) with the chief complaint of "panic attacks." In total, he was evaluated by 14 faculty physicians, 2 fellows, and 16 residents from emergency medicine, cardiology, neurology, psychiatry, and internal medi... |
15,559,220 | D000367:Age Factors; D000368:Aged; D000596:Amino Acids; D002545:Brain Ischemia; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D018697:Nootropic Agents; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012307:Risk Factors; D013349:Subclavian Steal Synd... | [
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] | [Clinical and pathogenetical peculiarities and treatment policy in ischemic stroke of elderly and old age]. | The data on randomized study of 2 groups of patients with ischemic brain hemisphere stroke of elderly and old (over 70 years) as well as middle (under 60 years) age are presented. In elderly and old age, stroke develops on the basis of common affection of major vessels, with a great role of the "steal syndrome" in its ... | null | false | [Clinical and pathogenetical peculiarities and treatment policy in ischemic stroke of elderly and old age]. The data on randomized study of 2 groups of patients with ischemic brain hemisphere stroke of elderly and old (over 70 years) as well as middle (under 60 years) age are presented. In elderly and old age, stroke d... |
30,464,137 | D000368:Aged; D001783:Blood Flow Velocity; D006328:Cardiac Catheterization; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain;... | [
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"D008297",
"D008875",
"D020097",
"D014655",
"D016278"
] | Analysis of Biphasic Right Ventricular Outflow Doppler Waveform in Patients with Pulmonary Hypertension. | Pulmonary hypertension (PH) with pulmonary vascular disease (PVD) is a progressive and debilitating disease associated with increased pulmonary vascular resistance (PVR). Biphasic right ventricular outflow tract (RVOT) Doppler flow is frequently seen in severe PH patients with PVD. In association with hemodynamics, the... | null | false | Analysis of Biphasic Right Ventricular Outflow Doppler Waveform in Patients with Pulmonary Hypertension. Pulmonary hypertension (PH) with pulmonary vascular disease (PVD) is a progressive and debilitating disease associated with increased pulmonary vascular resistance (PVR). Biphasic right ventricular outflow tract (RV... |
16,275,434 | D000368:Aged; D000369:Aged, 80 and over; D019917:Blood Vessel Prosthesis Implantation; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis; D002560:Cerebrovascular Circulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D020766:Intracranial Embolism; D008279:Magnetic Resonance ... | [
"D000368",
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"D019917",
"D002343",
"D016893",
"D002560",
"D005260",
"D005500",
"D006801",
"D015994",
"D020766",
"D008279",
"D008297",
"D008875",
"D011183",
"D011446",
"D011474",
"D011475",
"D012307",
"D015607"
] | Cerebral microembolization after protected carotid artery stenting in surgical high-risk patients: results of a 2-year prospective study. | BACKGROUND
This was a prospective single-center study to assess and analyze cerebral embolization resulting from carotid artery stenting with neuroprotective filter devices in patients considered as poor surgical candidates for surgical carotid endarterectomy.
METHODS
Fifty-three consecutive patients with an internal... | null | false | Cerebral microembolization after protected carotid artery stenting in surgical high-risk patients: results of a 2-year prospective study. BACKGROUND
This was a prospective single-center study to assess and analyze cerebral embolization resulting from carotid artery stenting with neuroprotective filter devices in patien... |
20,846,597 | D015415:Biomarkers; D001706:Biopsy; D009202:Cardiomyopathies; D019091:Critical Pathways; D004452:Echocardiography; D006801:Humans; D007501:Iron; D019190:Iron Overload; D008279:Magnetic Resonance Imaging; D009206:Myocardium; D014057:Tomography, X-Ray Computed | [
"D015415",
"D001706",
"D009202",
"D019091",
"D004452",
"D006801",
"D007501",
"D019190",
"D008279",
"D009206",
"D014057"
] | Iron overload cardiomyopathy: better understanding of an increasing disorder. | The prevalence of iron overload cardiomyopathy (IOC) is increasing. The spectrum of symptoms of IOC is varied. Early in the disease process, patients may be asymptomatic, whereas severely overloaded patients can have terminal heart failure complaints that are refractory to treatment. It has been shown that early recogn... | 11,653,542 | true | Iron overload cardiomyopathy: better understanding of an increasing disorder. The prevalence of iron overload cardiomyopathy (IOC) is increasing. The spectrum of symptoms of IOC is varied. Early in the disease process, patients may be asymptomatic, whereas severely overloaded patients can have terminal heart failure co... |
27,697,440 | D000991:Antithrombins; D000066491:Clinical Decision-Making; D000069604:Dabigatran; D065427:Factor Xa Inhibitors; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D020300:Intracranial Hemorrhages; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D013923:Thromboembolism | [
"D000991",
"D000066491",
"D000069604",
"D065427",
"D006471",
"D006801",
"D020300",
"D017410",
"D018570",
"D013923"
] | Re-initiation of dabigatran and direct factor Xa antagonists after a major bleed. | Direct oral anticoagulants (DOACs) are a relatively recent addition to the oral anticoagulant armamentarium, and provide an alternative to the use of vitamin K antagonists such as warfarin. Regardless of the type of agent used, bleeding is the major complication of anticoagulant therapy. The decision to restart oral an... | 8,080,679 | true | Re-initiation of dabigatran and direct factor Xa antagonists after a major bleed. Direct oral anticoagulants (DOACs) are a relatively recent addition to the oral anticoagulant armamentarium, and provide an alternative to the use of vitamin K antagonists such as warfarin. Regardless of the type of agent used, bleeding i... |
27,697,440 | D000991:Antithrombins; D000066491:Clinical Decision-Making; D000069604:Dabigatran; D065427:Factor Xa Inhibitors; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D020300:Intracranial Hemorrhages; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D013923:Thromboembolism | [
"D000991",
"D000066491",
"D000069604",
"D065427",
"D006471",
"D006801",
"D020300",
"D017410",
"D018570",
"D013923"
] | Re-initiation of dabigatran and direct factor Xa antagonists after a major bleed. | Direct oral anticoagulants (DOACs) are a relatively recent addition to the oral anticoagulant armamentarium, and provide an alternative to the use of vitamin K antagonists such as warfarin. Regardless of the type of agent used, bleeding is the major complication of anticoagulant therapy. The decision to restart oral an... | 10,141,236 | true | Re-initiation of dabigatran and direct factor Xa antagonists after a major bleed. Direct oral anticoagulants (DOACs) are a relatively recent addition to the oral anticoagulant armamentarium, and provide an alternative to the use of vitamin K antagonists such as warfarin. Regardless of the type of agent used, bleeding i... |
160,516 | D000368:Aged; D006332:Cardiomegaly; D004935:Esophageal Diseases; D005260:Female; D006325:Heart Atria; D006801:Humans; D011189:Potassium Chloride; D014456:Ulcer | [
"D000368",
"D006332",
"D004935",
"D005260",
"D006325",
"D006801",
"D011189",
"D014456"
] | Oesophageal ulceration due to slow-release potassium in the presence of left atrial enlargement. | Ulceration of the oesophagus was suspected clinically and confirmed radiologically in a patient with an enlarged left atrium while on treatment with slow release potassium chloride. Its discontinuation resulted in resolution of symptoms. This potentially serious complication of treatment should be considered in patient... | 1,081,703 | true | Oesophageal ulceration due to slow-release potassium in the presence of left atrial enlargement. Ulceration of the oesophagus was suspected clinically and confirmed radiologically in a patient with an enlarged left atrium while on treatment with slow release potassium chloride. Its discontinuation resulted in resolutio... |
33,805,763 | D064987:Cell- and Tissue-Based Therapy; D006333:Heart Failure; D006801:Humans; D009206:Myocardium; D032383:Myocytes, Cardiac; D023822:Tissue Engineering | [
"D064987",
"D006333",
"D006801",
"D009206",
"D032383",
"D023822"
] | Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out? | Cardiovascular disease (CVD) is still the leading cause of death worldwide. Coronary artery occlusion, or myocardial infarction (MI) causes massive loss of cardiomyocytes. The ischemia area is eventually replaced by a fibrotic scar. From the mechanical dysfunctions of the scar in electronic transduction, contraction an... | 4,444,606 | true | Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out? Cardiovascular disease (CVD) is still the leading cause of death worldwide. Coronary artery occlusion, or myocardial infarction (MI) causes massive loss of cardiomyocytes. The ischemia area is eventually replaced by a fibrotic scar. From the mechanica... |
24,951,664 | D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001786:Blood Glucose; D002880:Chromosomes, Human, Pair 11; D015331:Cohort Studies; D053418:Death Domain Receptor Signaling Adaptor Proteins; D003924:Diabetes Mellitus, Type 2; D005215:Fasting; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D05... | [
"D000368",
"D000369",
"D000375",
"D001786",
"D002880",
"D015331",
"D053418",
"D003924",
"D005215",
"D005260",
"D005787",
"D014644",
"D055106",
"D023281",
"D020662",
"D006331",
"D006801",
"D007328",
"D008297",
"D008875",
"D020641",
"D017422"
] | Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. | BACKGROUND
Common variation at the 11p11.2 locus, encompassing MADD, ACP2, NR1H3, MYBPC3, and SPI1, has been associated in genome-wide association studies with fasting glucose and insulin (FI). In the Cohorts for Heart and Aging Research in Genomic Epidemiology Targeted Sequencing Study, we sequenced 5 gene regions at ... | null | false | Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. BACKGROUND
Common variation at the 11p11.2 locus, encompassing MADD, ACP2, NR1H3, MYBPC3, and SPI1, ha... |
23,336,931 | D017311:Amlodipine; D000818:Animals; D000959:Antihypertensive Agents; D000069059:Atorvastatin; D002340:Carotid Artery Diseases; D017536:Carotid Artery, Common; D018932:Chemokine CCL2; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004359:Drug Therapy, Combination; D042783:Endothelial Cells; D006538:Heptanoic Acids; D0... | [
"D017311",
"D000818",
"D000959",
"D000069059",
"D002340",
"D017536",
"D018932",
"D050759",
"D004359",
"D042783",
"D006538",
"D019161",
"D008297",
"D011758",
"D051381",
"D056564",
"D016159"
] | Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats. | OBJECTIVE
Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases.
METHODS
We studied effects of amlodipine, atorvastatin, and their combination on carotid arteriosclerotic processes in a metabolic syndrome model of Zucker fatty rats. Zucker fatty rats were treated w... | null | false | Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats. OBJECTIVE
Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases.
METHODS
We studied effects of amlodipine, atorvastatin, and their combination on caro... |
8,060,581 | D000328:Adult; D001786:Blood Glucose; D004039:Diet, Sodium-Restricted; D005260:Female; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension; D007328:Insulin; D008297:Male; D008875:Middle Aged | [
"D000328",
"D001786",
"D004039",
"D005260",
"D018149",
"D005951",
"D006801",
"D006973",
"D007328",
"D008297",
"D008875"
] | Dietary NaCl restriction deteriorates oral glucose tolerance in hypertensive patients with impairment of glucose tolerance. | This study investigated whether the change of glycemic response to oral glucose loading with an increase of dietary NaCl intake is different between salt-sensitive and salt-resistant groups, or whether it is related to glucose tolerance on a low NaCl diet independent of salt sensitivity. The plasma glucose and insulin ... | 7,575,587 | true | Dietary NaCl restriction deteriorates oral glucose tolerance in hypertensive patients with impairment of glucose tolerance. This study investigated whether the change of glycemic response to oral glucose loading with an increase of dietary NaCl intake is different between salt-sensitive and salt-resistant groups, or wh... |
2,310,255 | D000293:Adolescent; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006325:Heart Atria; D006327:Heart Block; D006346:Heart Septum; D006801:Humans; D013617:Tachycardia, Supraventricular | [
"D000293",
"D004562",
"D015716",
"D005260",
"D006325",
"D006327",
"D006346",
"D006801",
"D013617"
] | Surgical cure of automatic atrial tachycardia by partial left atrial isolation. | Partial left atrial isolation was performed in a 16-year-old girl with persistent atrial tachycardia refractory to antiarrhythmic agents for 3 years. Intraoperative atrial epicardial and endocardial mapping showed that the earliest atrial activation occurred in an area lateral to the junction of the right superior pulm... | 7,445,756 | true | Surgical cure of automatic atrial tachycardia by partial left atrial isolation. Partial left atrial isolation was performed in a 16-year-old girl with persistent atrial tachycardia refractory to antiarrhythmic agents for 3 years. Intraoperative atrial epicardial and endocardial mapping showed that the earliest atrial a... |
22,721,898 | D000293:Adolescent; D000328:Adult; D000368:Aged; D005165:Factor V; D005260:Female; D005838:Genotype; D006801:Humans; D020767:Intracranial Thrombosis; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011516:P... | [
"D000293",
"D000328",
"D000368",
"D005165",
"D005260",
"D005838",
"D006801",
"D020767",
"D008297",
"D042965",
"D008875",
"D011110",
"D020641",
"D011516",
"D012307",
"D014416",
"D020246",
"D055815"
] | Thrombophilic polymorphisms - factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T - in Tunisian patients with cerebral venous thrombosis. | Cerebral venous thrombosis (CVT) has been associated with thrombophilic defects. We performed a study to evaluate the role of three single nucleotide polymorphisms (SNP), factor V Leiden G1691A (FVL), prothrombin gene mutation G20210A (FII-G20210A) and methylenotetrahydrofolate reductase variant C677T (MTHFR-C677T), as... | 13,980,158 | true | Thrombophilic polymorphisms - factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T - in Tunisian patients with cerebral venous thrombosis. Cerebral venous thrombosis (CVT) has been associated with thrombophilic defects. We performed a study to evaluate the role of three single nucleotide polymorphisms (SNP), fac... |
37,166,820 | D006801:Humans; D000068258:Bevacizumab; D012170:Retinal Vein Occlusion; D008269:Macular Edema; D020533:Angiogenesis Inhibitors; D040262:Receptors, Vascular Endothelial Growth Factor; D011993:Recombinant Fusion Proteins; D058449:Intravitreal Injections | [
"D006801",
"D000068258",
"D012170",
"D008269",
"D020533",
"D040262",
"D011993",
"D058449"
] | Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial. | Retinal vein occlusion is the second most common retinal vascular disease. Bevacizumab was demonstrated in the Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) to be noninferior to aflibercept with respect to visual acuity in study participants with macular edema due to central retinal vein occlusi... | null | false | Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial. Retinal vein occlusion is the second most common retinal vascular disease. Bevacizumab was demonstrated in the Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) to be... |
32,028,046 | D000328:Adult; D016757:Death, Sudden, Cardiac; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult | [
"D000328",
"D016757",
"D005260",
"D006801",
"D015994",
"D008297",
"D008875",
"D011159",
"D056910",
"D012189",
"D018570",
"D012307",
"D055815"
] | Short stature is associated with incident sudden cardiac death in a large Asian cohort. | Few data on the association between height and the risk of sudden cardiac death (SCD) in Asian populations are available.
The purpose of this study was to assess the risk of SCD as related to height both in a representative Korean population and in specific subgroups.
This is a retrospective cohort study of 410,1... | null | false | Short stature is associated with incident sudden cardiac death in a large Asian cohort. Few data on the association between height and the risk of sudden cardiac death (SCD) in Asian populations are available.
The purpose of this study was to assess the risk of SCD as related to height both in a representative Korea... |
18,413,598 | D017667:Adipocytes; D050156:Adipogenesis; D000273:Adipose Tissue; D000818:Animals; D002135:Calcium-Binding Proteins; D009202:Cardiomyopathies; D003924:Diabetes Mellitus, Type 2; D020022:Genetic Predisposition to Disease; D005934:Glucagon; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D024821:M... | [
"D017667",
"D050156",
"D000273",
"D000818",
"D002135",
"D009202",
"D003924",
"D020022",
"D005934",
"D007328",
"D036341",
"D024821",
"D051379",
"D008822",
"D009765",
"D010179",
"D011401",
"D012333",
"D054411",
"D051780",
"D019076"
] | Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. | To determine whether adipocyte storage capacity influences the onset and severity of type 2 diabetes and other components of the metabolic syndrome, we made normal and db/db mice resistant to obesity by overexpressing leptin receptor-b on the aP2-Lepr-b promoter. On a 4% diet, these mice have no phenotype, but on a 60%... | 2,852,628 | true | Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. To determine whether adipocyte storage capacity influences the onset and severity of type 2 diabetes and other components of the metabolic syndrome, we made normal and db/db mice resistant to obesity by overexpressing leptin receptor-... |
37,043,326 | D006801:Humans; D000818:Animals; D051379:Mice; D004195:Disease Models, Animal; D061088:Photoacoustic Techniques; D012151:Resuscitation; D006323:Heart Arrest; D000860:Hypoxia | [
"D006801",
"D000818",
"D051379",
"D004195",
"D061088",
"D012151",
"D006323",
"D000860"
] | Neurovascular Hypoxia Trajectories Assessed by Photoacoustic Imaging in a Murine Model of Cardiac Arrest and Resuscitation. | Cardiac arrest is a common cause of death annually mainly due to postcardiac arrest syndrome that leads to multiple organ global hypoxia and dysfunction after resuscitation. The ability to quantify vasculature changes and tissue oxygenation is crucial to adapt patient treatment in order to minimize major outcomes after... | null | false | Neurovascular Hypoxia Trajectories Assessed by Photoacoustic Imaging in a Murine Model of Cardiac Arrest and Resuscitation. Cardiac arrest is a common cause of death annually mainly due to postcardiac arrest syndrome that leads to multiple organ global hypoxia and dysfunction after resuscitation. The ability to quantif... |
37,558,295 | D006801:Humans; D006331:Heart Diseases; D005820:Genetic Testing; D009202:Cardiomyopathies; D001145:Arrhythmias, Cardiac; D005817:Genetic Counseling | [
"D006801",
"D006331",
"D005820",
"D009202",
"D001145",
"D005817"
] | A Practical Guide to Genetic Testing in Inherited Heart Disease. | Genetic testing has increasingly been shown to provide critical information regarding the treatment and management of patients with hereditary cardiomyopathies and arrhythmias and is available for a wide variety of conditions. It can provide information regarding arrhythmia risk, lifestyle recommendations, such as exer... | null | false | A Practical Guide to Genetic Testing in Inherited Heart Disease. Genetic testing has increasingly been shown to provide critical information regarding the treatment and management of patients with hereditary cardiomyopathies and arrhythmias and is available for a wide variety of conditions. It can provide information r... |
8,538,901 | D017545:Aortic Aneurysm, Thoracic; D002102:Cadaver; D006801:Humans; D006965:Hyperplasia; D011093:Polyethylene Terephthalates; D019736:Prostheses and Implants; D017539:Tunica Intima | [
"D017545",
"D002102",
"D006801",
"D006965",
"D011093",
"D019736",
"D017539"
] | Pathological study of implanted dacron grafts in surgery of thoracic aortic aneurysms. | We studied woven dacron grafts that had been implanted in 5 patients of thoracic aortic aneurysms. In addition to usual stains, immunocytochemical analysis was performed using monoclonal antibodies to the muscle actin (HHF35) and to the macrophage (HAM56). In the graft of 5 and 24 days implantation, thin thrombi contai... | 14,348,338 | true | Pathological study of implanted dacron grafts in surgery of thoracic aortic aneurysms. We studied woven dacron grafts that had been implanted in 5 patients of thoracic aortic aneurysms. In addition to usual stains, immunocytochemical analysis was performed using monoclonal antibodies to the muscle actin (HHF35) and to ... |
16,583,933 | D001024:Aortic Valve Stenosis; D002404:Catheterization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016896:Treatment Outcome; D014463:Ultrasonography | [
"D001024",
"D002404",
"D006801",
"D007223",
"D007231",
"D008297",
"D016896",
"D014463"
] | [Transluminal balloon valvuloplasty in neonates and infants with critical aortic stenosis]. | The purpose of this study was to evaluate children who underwent balloon valvuloplasty due to critical aortic stenosis following clinical (low cardiac output, cardiogenic shock, congestive heart failure) and echocardiographic criteria (morphological evidence of left ventricular hypertrophy, with depression of left vent... | null | false | [Transluminal balloon valvuloplasty in neonates and infants with critical aortic stenosis]. The purpose of this study was to evaluate children who underwent balloon valvuloplasty due to critical aortic stenosis following clinical (low cardiac output, cardiogenic shock, congestive heart failure) and echocardiographic cr... |
30,870,037 | D000287:Administration, Topical; D017719:Diabetic Foot; D016503:Drug Delivery Systems; D000076722:Drug Development; D055808:Drug Discovery; D006801:Humans; D004364:Pharmaceutical Preparations; D014945:Wound Healing; D014947:Wounds and Injuries | [
"D000287",
"D017719",
"D016503",
"D000076722",
"D055808",
"D006801",
"D004364",
"D014945",
"D014947"
] | The discovery and development of topical medicines for wound healing. | Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibiotic resistance and the emerging use of health economy and value-based ... | null | false | The discovery and development of topical medicines for wound healing. Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibio... |
2,234,326 | D000818:Animals; D001769:Blood; D004195:Disease Models, Animal; D004912:Erythrocytes; D005263:Femoral Artery; D006801:Humans; D002546:Ischemic Attack, Transient; D007962:Leukocytes; D008297:Male; D010949:Plasma; D051381:Rats; D011919:Rats, Inbred Strains | [
"D000818",
"D001769",
"D004195",
"D004912",
"D005263",
"D006801",
"D002546",
"D007962",
"D008297",
"D010949",
"D051381",
"D011919"
] | A rat femoral artery model for vasospasm. | A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were perfusion-fixed and examined by light and tr... | 14,509,119 | true | A rat femoral artery model for vasospasm. A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were pe... |
2,755,121 | D000818:Animals; D001145:Arrhythmias, Cardiac; D003243:Consciousness; D003327:Coronary Disease; D004110:Diltiazem; D004562:Electrocardiography; D006339:Heart Rate; D008297:Male; D015428:Myocardial Reperfusion Injury; D009543:Nifedipine; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia; D014693:Ventricula... | [
"D000818",
"D001145",
"D003243",
"D003327",
"D004110",
"D004562",
"D006339",
"D008297",
"D015428",
"D009543",
"D051381",
"D011919",
"D013610",
"D014693",
"D014700"
] | Reperfusion-induced arrhythmias in the conscious rat: a comparative study with three calcium antagonists. | The effects of three calcium antagonists (diltiazem, verapamil, and nifedipine) on reperfusion-induced arrhythmias were compared in a conscious rat preparation with coronary artery occlusion and implanted electrocardiogram limb electrodes. Upon reperfusion after a 5-min period of occlusion, all (15/15) untreated contro... | 7,665,470 | true | Reperfusion-induced arrhythmias in the conscious rat: a comparative study with three calcium antagonists. The effects of three calcium antagonists (diltiazem, verapamil, and nifedipine) on reperfusion-induced arrhythmias were compared in a conscious rat preparation with coronary artery occlusion and implanted electroca... |
17,532,413 | D000293:Adolescent; D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D004724:Endoscopy; D005260:Female; D006338:Heart Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome | [
"D000293",
"D000328",
"D000368",
"D006348",
"D004724",
"D005260",
"D006338",
"D006801",
"D008297",
"D008875",
"D012189",
"D016896"
] | Endoscopic cardiac tumor resection. | BACKGROUND
The purpose of this study is to report our 9 years' experience with endoscopic cardiac tumor resection using the port access approach.
METHODS
From March 1997 to December 2005, 27 patients (mean age, 56.2 +/- 16.9 years; 70% female) underwent endoscopic cardiac tumor resection using endocardiopulmonary byp... | null | false | Endoscopic cardiac tumor resection. BACKGROUND
The purpose of this study is to report our 9 years' experience with endoscopic cardiac tumor resection using the port access approach.
METHODS
From March 1997 to December 2005, 27 patients (mean age, 56.2 +/- 16.9 years; 70% female) underwent endoscopic cardiac tumor res... |
17,578,050 | D000368:Aged; D000925:Anticoagulants; D001021:Aortic Valve; D017984:Enoxaparin; D005240:Feasibility Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006470:Hemorrhage; D006801:Humans; D019934:International Normalized Ratio; D008943:Mitral Valve; D019990:Perioperative Care; D011446:... | [
"D000368",
"D000925",
"D001021",
"D017984",
"D005240",
"D006350",
"D019918",
"D006470",
"D006801",
"D019934",
"D008943",
"D019990",
"D011446",
"D012042",
"D013923"
] | Periprocedural bridging therapy with low-molecular-weight heparin in chronically anticoagulated patients with prosthetic mechanical heart valves: experience in 116 patients from the prospective BRAVE registry. | OBJECTIVE
The study aim was to determine the safety and feasibility of a standardized bridging regimen in patients with mechanical heart valves at high thromboembolic risk, using low-molecular-weight heparin (LMWH).
METHODS
Since the year 2000, all patients at the authors' institution, with mechanical heart valves an... | null | false | Periprocedural bridging therapy with low-molecular-weight heparin in chronically anticoagulated patients with prosthetic mechanical heart valves: experience in 116 patients from the prospective BRAVE registry. OBJECTIVE
The study aim was to determine the safety and feasibility of a standardized bridging regimen in pati... |
20,881,568 | D017542:Aneurysm, Ruptured; D002543:Cerebral Hemorrhage; D002552:Cerebral Ventricles; D015331:Cohort Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009422:Nervous System Diseases; D011237:Predictive Valu... | [
"D017542",
"D002543",
"D002552",
"D015331",
"D005260",
"D006801",
"D002532",
"D016015",
"D008297",
"D008875",
"D015999",
"D009422",
"D011237",
"D012189",
"D012720",
"D016896"
] | Intraventricular hemorrhage volume predicts poor outcomes but not delayed ischemic neurological deficits among patients with ruptured cerebral aneurysms. | BACKGROUND
Intraventricular hemorrhage (IVH) predicts worse outcomes following aneurysmal subarachnoid hemorrhage (SAH). One potential mechanism is that IVH predisposes to the development of delayed ischemic neurological deficits (DINDs). No previous studies have evaluated the association between IVH volume (in millili... | null | false | Intraventricular hemorrhage volume predicts poor outcomes but not delayed ischemic neurological deficits among patients with ruptured cerebral aneurysms. BACKGROUND
Intraventricular hemorrhage (IVH) predicts worse outcomes following aneurysmal subarachnoid hemorrhage (SAH). One potential mechanism is that IVH predispos... |
12,939,567 | D003327:Coronary Disease; D006801:Humans; D006973:Hypertension; D007333:Insulin Resistance | [
"D003327",
"D006801",
"D006973",
"D007333"
] | Insulin resistance, hypertension, and coronary heart disease. | The goals of this review are two-fold: to examine the evidence in support of a role for insulin resistance and compensatory hyperinsulinemia in the pathogenesis of essential hypertension, and to evaluate the hypothesis that insulin resistance and its manifestations play major roles in the development of coronary heart ... | 6,421,089 | true | Insulin resistance, hypertension, and coronary heart disease. The goals of this review are two-fold: to examine the evidence in support of a role for insulin resistance and compensatory hyperinsulinemia in the pathogenesis of essential hypertension, and to evaluate the hypothesis that insulin resistance and its manifes... |
9,391,222 | D000368:Aged; D002121:Calcium Channel Blockers; D002561:Cerebrovascular Disorders; D003680:Deglutition Disorders; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine; D010865:Pilot Projects | [
"D000368",
"D002121",
"D002561",
"D003680",
"D004311",
"D005260",
"D006801",
"D008297",
"D009543",
"D010865"
] | Pharmacological treatment of dysphagia in stroke. | The pharynx is important for a normal swallow and it has been suggested that pharmacological agents may play a role in the management of pharyngeal dysphagia, but none have been formally evaluated. A pilot double-blind, placebo-controlled study was undertaken in 17 hospitalized patients with persistent dysphagia 2 week... | 2,903,413 | true | Pharmacological treatment of dysphagia in stroke. The pharynx is important for a normal swallow and it has been suggested that pharmacological agents may play a role in the management of pharyngeal dysphagia, but none have been formally evaluated. A pilot double-blind, placebo-controlled study was undertaken in 17 hosp... |
29,878,125 | D000199:Actins; D000293:Adolescent; D000328:Adult; D000818:Animals; D002311:Cardiomyopathy, Dilated; D016022:Case-Control Studies; D051338:Cofilin 1; D005260:Female; D006321:Heart; D006801:Humans; D034904:Lamin Type A; D008297:Male; D051379:Mice; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1; D048052:... | [
"D000199",
"D000293",
"D000328",
"D000818",
"D002311",
"D016022",
"D051338",
"D005260",
"D006321",
"D006801",
"D034904",
"D008297",
"D051379",
"D008875",
"D019950",
"D048052",
"D009154",
"D010766",
"D015398",
"D055815"
] | Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. | Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is unknown. We show that active phosphorylated ERK1/2 directly binds to and catalyzes... | 4,535,839 | true | Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy).... |
15,338,141 | D002545:Brain Ischemia; D002986:Clinical Trials as Topic; D015897:Comorbidity; D019317:Evidence-Based Medicine; D005260:Female; D005343:Fibrinolytic Agents; D005858:Germany; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke; D019851:Thromb... | [
"D002545",
"D002986",
"D015897",
"D019317",
"D005260",
"D005343",
"D005858",
"D006801",
"D015994",
"D008297",
"D015995",
"D018570",
"D012307",
"D020521",
"D019851"
] | [Thrombophilias in patients with ischemic stroke. Indication and calculated costs for evidence-based diagnostics and treatment]. | Patients with ischemic stroke are sometimes found to have an underlying inherited (deficiency of protein C, protein S, antithrombin III, activated protein C resistance, prothrombin gene mutation, hyperhomocysteinemia) or acquired thrombophilia (lupus anticoagulant and anticardiolipin antibodies, hyperhomocysteinemia). ... | null | false | [Thrombophilias in patients with ischemic stroke. Indication and calculated costs for evidence-based diagnostics and treatment]. Patients with ischemic stroke are sometimes found to have an underlying inherited (deficiency of protein C, protein S, antithrombin III, activated protein C resistance, prothrombin gene mutat... |
19,436,803 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency; D001024:Aortic Valve Stenosis; D002648:Child; D004697:Endocarditis, Bacterial; D005260:Female; D006330:Heart Defects, Congenital; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008... | [
"D000293",
"D000328",
"D000367",
"D000368",
"D001021",
"D001022",
"D001024",
"D002648",
"D004697",
"D005260",
"D006330",
"D017052",
"D006801",
"D008297",
"D008875",
"D011379",
"D016016",
"D012189",
"D018570",
"D012307",
"D014463",
"D055815"
] | Impact of bicuspid aortic valve on complications and death in infective endocarditis of native aortic valves. | We retrospectively investigated the impact of bicuspid aortic valve on the prognosis of patients who had definite infective endocarditis of the native aortic valve.Of 51 patients, a bicuspid aortic valve was present in 22 (43%); the other 29 had tricuspid aortic valves. On average, the patients who had bicuspid valves ... | 2,240,429 | true | Impact of bicuspid aortic valve on complications and death in infective endocarditis of native aortic valves. We retrospectively investigated the impact of bicuspid aortic valve on the prognosis of patients who had definite infective endocarditis of the native aortic valve.Of 51 patients, a bicuspid aortic valve was pr... |
23,443,603 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019917:Blood Vessel Prosthesis Implantation; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005343:Fibrinolytic Agents; D006083:Graft Occlusion, Vascular; D006470:Hemorrhage; D006493:Heparin; D006495:Heparin, Low-... | [
"D000328",
"D000368",
"D000369",
"D019917",
"D004305",
"D004334",
"D005260",
"D005343",
"D006083",
"D006470",
"D006493",
"D006495",
"D006801",
"D035002",
"D008297",
"D008875",
"D018579",
"D058729",
"D012307",
"D013927",
"D013997",
"D016896",
"D014654"
] | Risk-adjusted strategies in the prevention of early arterial thrombosis following lower extremity arterial reconstruction: a comparison of unfractionated versus low molecular weight heparin. | OBJECTIVE
In vascular surgery postoperative thrombosis prophylaxis must sufficiently prevent arterial thrombosis. This cohort study examines different therapeutic approaches of unfractionated heparin (UFH) or low molecular weight heparin (LMWH) after vascular reconstruction.
METHODS
Four hundred seventy-five patients... | null | false | Risk-adjusted strategies in the prevention of early arterial thrombosis following lower extremity arterial reconstruction: a comparison of unfractionated versus low molecular weight heparin. OBJECTIVE
In vascular surgery postoperative thrombosis prophylaxis must sufficiently prevent arterial thrombosis. This cohort stu... |
20,044,737 | D030541:Databases, Genetic; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension; D008297:Male; D011941:Receptors, Adrenergic | [
"D030541",
"D005260",
"D056726",
"D020022",
"D006801",
"D006973",
"D008297",
"D011941"
] | Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database. | BACKGROUND
The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive. To clarify these data, a systematic assessment of GAS for adrenoceptor family genes in hyper... | null | false | Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database. BACKGROUND
The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic associat... |
30,797,031 | D000368:Aged; D000784:Aortic Dissection; D001013:Aorta, Thoracic; D017545:Aortic Aneurysm, Thoracic; D019917:Blood Vessel Prosthesis Implantation; D002140:California; D057510:Endovascular Procedures; D006764:Hospitals, Community; D016304:Hospitals, Private; D006801:Humans; D061214:Patient Safety; D011183:Postoperative ... | [
"D000368",
"D000784",
"D001013",
"D017545",
"D019917",
"D002140",
"D057510",
"D006764",
"D016304",
"D006801",
"D061214",
"D011183",
"D018570",
"D012307",
"D013997",
"D016896"
] | Hybrid Aortic Arch Debranching and TEVAR Is Safe in a Private, Community Hospital. | BACKGROUND
Hybrid open cervical vessel debranching and thoracic endovascular aortic repair (TEVAR) is a treatment option in the management of aortic arch or proximal descending thoracic aortic aneurysms. However, these patients are often referred to tertiary care academic centers for aneurysm repair. Our study looks to... | null | false | Hybrid Aortic Arch Debranching and TEVAR Is Safe in a Private, Community Hospital. BACKGROUND
Hybrid open cervical vessel debranching and thoracic endovascular aortic repair (TEVAR) is a treatment option in the management of aortic arch or proximal descending thoracic aortic aneurysms. However, these patients are often... |
16,639,688 | D000368:Aged; D001243:Assisted Circulation; D002294:Carcinoma, Squamous Cell; D003131:Combined Modality Therapy; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008175:Lung Neoplasms; D008297:Male; D011013:Pneumonectomy; D019106:Postoperative Hemorrhage; D011651:Pulmo... | [
"D000368",
"D001243",
"D002294",
"D003131",
"D015199",
"D006801",
"D007423",
"D008175",
"D008297",
"D011013",
"D019106",
"D011651",
"D012770",
"D012771"
] | Mechanical circulatory support for profound cardiac circulatory shock status due to postoperative pulmonary artery bleeding. | A 77-year-old patient suffering from life-threatening pulmonary artery bleeding after pulmonary lobectomy was resuscitated but had refractory cardiogenic shock after the bleeding was controlled. We used mechanical circulatory support with extracorporeal membrane oxygenation and intra-aortic balloon pump to overcome the... | 11,887,378 | true | Mechanical circulatory support for profound cardiac circulatory shock status due to postoperative pulmonary artery bleeding. A 77-year-old patient suffering from life-threatening pulmonary artery bleeding after pulmonary lobectomy was resuscitated but had refractory cardiogenic shock after the bleeding was controlled. ... |
9,501,819 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005268:Femoral Vein; D005544:Forecasting; D006439:Hemodynamics; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D011152:Popliteal Vein; D012307:Risk Factors; D012501:Saphenous Vein; D014648:Varicose Veins; D0146... | [
"D000293",
"D000328",
"D000368",
"D000369",
"D005260",
"D005268",
"D005544",
"D006439",
"D006801",
"D007866",
"D008297",
"D008875",
"D011152",
"D012307",
"D012501",
"D014648",
"D014689"
] | Correlation of the anatomical distribution of venous reflux with clinical symptoms and venous haemodynamics in primary varicose veins. | OBJECTIVE
The aim of this study was to correlate the anatomical distribution of venous reflux with clinical symptoms and venous haemodynamics in patients with primary varicose veins.
METHODS
Venous reflux was examined using duplex colour Doppler ultrasonography in 266 legs in 191 patients. The venous refilling and re... | null | false | Correlation of the anatomical distribution of venous reflux with clinical symptoms and venous haemodynamics in primary varicose veins. OBJECTIVE
The aim of this study was to correlate the anatomical distribution of venous reflux with clinical symptoms and venous haemodynamics in patients with primary varicose veins.
... |
32,559,680 | D000368:Aged; D000784:Aortic Dissection; D000971:Antineoplastic Combined Chemotherapy Protocols; D001027:Aortography; D000072226:Computed Tomography Angiography; D003287:Contrast Media; D003561:Cytarabine; D020000:Decision Support Systems, Clinical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D01... | [
"D000368",
"D000784",
"D000971",
"D001027",
"D000072226",
"D003287",
"D003561",
"D020000",
"D005260",
"D006801",
"D008297",
"D008875",
"D011829",
"D000069079",
"D012189",
"D013866",
"D014057"
] | Implementation of an aortic dissection CT protocol with clinical decision support aimed at decreasing radiation exposure by reducing routine abdominopelvic imaging. | Patients suspected of having an acute aortic syndrome in the ED typically undergo CT of the chest/abdomen/pelvis. However, the overwhelming majority of these exams are negative. With the help of clinical decision support, we implemented a new radiologist monitored 'aortic dissection screening protocol' that forgoes rou... | 6,479,876 | true | Implementation of an aortic dissection CT protocol with clinical decision support aimed at decreasing radiation exposure by reducing routine abdominopelvic imaging. Patients suspected of having an acute aortic syndrome in the ED typically undergo CT of the chest/abdomen/pelvis. However, the overwhelming majority of the... |
11,723,364 | D004562:Electrocardiography; D006801:Humans; D006973:Hypertension; D017379:Hypertrophy, Left Ventricular; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged | [
"D004562",
"D006801",
"D006973",
"D017379",
"D007089",
"D008297",
"D008875"
] | Hypertension images: electrocardiographic left ventricular hypertrophy. | The electrocardiogram is an inexpensive adjunct for assessing target organ damage in hypertensive patients. The gender-specific Cornell voltage criteria (men: R(aVL) + S(V3) >35 mm; women: R(aVL) + S(V3) >25 mm) have better overall accuracy than the often-used Sokolow-Lyon or Romhilt-Estes criteria. One of the earliest... | 12,820,299 | true | Hypertension images: electrocardiographic left ventricular hypertrophy. The electrocardiogram is an inexpensive adjunct for assessing target organ damage in hypertensive patients. The gender-specific Cornell voltage criteria (men: R(aVL) + S(V3) >35 mm; women: R(aVL) + S(V3) >25 mm) have better overall accuracy than th... |
2,300,981 | D000818:Animals; D001418:Baclofen; D002545:Brain Ischemia; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values | [
"D000818",
"D001418",
"D002545",
"D004305",
"D008297",
"D009043",
"D051381",
"D011919",
"D012016"
] | Baclofen does not protect against cerebral ischemia in rats. | Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampa... | 14,057,442 | true | Baclofen does not protect against cerebral ischemia in rats. Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, o... |
8,104,241 | D000319:Adrenergic beta-Antagonists; D000818:Animals; D000975:Antioxidants; D002227:Carbazoles; D000077261:Carvedilol; D004285:Dogs; D016166:Free Radical Scavengers; D006321:Heart; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009203:Myocardial Infarction; D011412:Propanolamines; D051381:Rats; D017207:Rats... | [
"D000319",
"D000818",
"D000975",
"D002227",
"D000077261",
"D004285",
"D016166",
"D006321",
"D006801",
"D015227",
"D008297",
"D009203",
"D011412",
"D051381",
"D017207",
"D013552",
"D013556",
"D014665"
] | Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. | OBJECTIVE
Carvedilol is a multiple action antihypertensive drug with potential use in angina and congestive heart failure. The pharmacological profile of carvedilol includes both beta-adrenoceptor blockade and vasodilation, the latter primarily a result of alpha 1-adrenoceptor blockade. Since many beta-blockers have ca... | null | false | Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. OBJECTIVE
Carvedilol is a multiple action antihypertensive drug with potential use in angina and congestive heart failure. The pharmacological profile of carvedilol includes both beta-adrenoceptor blo... |
2,418,290 | D000200:Action Potentials; D000818:Animals; D001145:Arrhythmias, Cardiac; D001794:Blood Pressure; D004285:Dogs; D004558:Electric Stimulation; D006329:Heart Conduction System; D006339:Heart Rate; D066298:In Vitro Techniques; D009203:Myocardial Infarction; D013928:Thromboxane A2 | [
"D000200",
"D000818",
"D001145",
"D001794",
"D004285",
"D004558",
"D006329",
"D006339",
"D066298",
"D009203",
"D013928"
] | Thromboxane A2 does not contribute to arrhythmogenesis during evolving canine myocardial infarction. | During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmias. We have recently shown an increased synthetic capacity within an evolving infarct for thromboxane... | 3,914,614 | true | Thromboxane A2 does not contribute to arrhythmogenesis during evolving canine myocardial infarction. During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmi... |
25,754,018 | D000368:Aged; D000465:Algorithms; D002932:Cineangiography; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D000069079:Radiation Exposure; D011857:Radio... | [
"D000368",
"D000465",
"D002932",
"D017023",
"D003324",
"D003331",
"D005260",
"D006801",
"D008297",
"D008875",
"D011237",
"D011829",
"D000069079",
"D011857",
"D015203"
] | Novel X-ray imaging technology enables significant patient dose reduction in interventional cardiology while maintaining diagnostic image quality. | OBJECTIVE
The purpose of this study was to quantify the reduction in patient radiation dose during coronary angiography (CA) by a new X-ray technology, and to assess its impact on diagnostic image quality.
BACKGROUND
Recently, a novel X-ray imaging technology has become available for interventional cardiology, using ... | null | false | Novel X-ray imaging technology enables significant patient dose reduction in interventional cardiology while maintaining diagnostic image quality. OBJECTIVE
The purpose of this study was to quantify the reduction in patient radiation dose during coronary angiography (CA) by a new X-ray technology, and to assess its imp... |
10,199,492 | D000328:Adult; D000799:Angioedema; D003613:Danazol; D017742:Dental Care for Chronically Ill; D004965:Estrogen Antagonists; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D013515:Surgery, Oral; D013997:Time Factors | [
"D000328",
"D000799",
"D003613",
"D017742",
"D004965",
"D005260",
"D005500",
"D006801",
"D008297",
"D008875",
"D011182",
"D011300",
"D013515",
"D013997"
] | The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures. | OBJECTIVE
This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures.
METHODS
Twelve patients with a history of edema after dental procedures were administered danazol (600 mg/d) 4 days preoperatively and 4 days postoperatively. ... | null | false | The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures. OBJECTIVE
This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures.
METHODS
Twelve patients with a... |
12,013,669 | D000368:Aged; D001932:Brain Neoplasms; D002543:Cerebral Hemorrhage; D004806:Ependymoma; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012008:Recurrence; D014057:Tomography, X-Ray Computed | [
"D000368",
"D001932",
"D002543",
"D004806",
"D005260",
"D006801",
"D008279",
"D012008",
"D014057"
] | Brain surface ependymoma with repeated episodes of intratumoral hemorrhage--case report. | A 70-year-old woman presented with a rare brain surface ependymoma with repeated intratumoral hemorrhage. She was admitted with progressive dementia. Two years earlier, a diagnosis of subcortical hematoma in the right frontal lobe had been made following a fall. On admission, magnetic resonance imaging showed a huge ri... | 13,039,304 | true | Brain surface ependymoma with repeated episodes of intratumoral hemorrhage--case report. A 70-year-old woman presented with a rare brain surface ependymoma with repeated intratumoral hemorrhage. She was admitted with progressive dementia. Two years earlier, a diagnosis of subcortical hematoma in the right frontal lobe ... |
34,656,119 | D054058:Acute Coronary Syndrome; D000077144:Clopidogrel; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors; D011788:Quality of Life; D000077486:Ticagrelor; D016896:Treatment Outcome | [
"D054058",
"D000077144",
"D006801",
"D062645",
"D010975",
"D011788",
"D000077486",
"D016896"
] | Comparison of ticagrelor with clopidogrel on quality of life in patients with acute coronary syndrome. | BACKGROUND
Ticagrelor has a Class I recommendation for use following percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS). However, ticagrelor needs to be taken twice a day, as compared to clopidogrel. Its adverse effects, such as dyspnea or bleeding, are known to be more common than with clopidogr... | null | false | Comparison of ticagrelor with clopidogrel on quality of life in patients with acute coronary syndrome. BACKGROUND
Ticagrelor has a Class I recommendation for use following percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS). However, ticagrelor needs to be taken twice a day, as compared to clopido... |
15,539,006 | D001850:Bone Diseases, Infectious; D017719:Diabetic Foot; D003929:Diabetic Neuropathies; D003937:Diagnosis, Differential; D020233:Gait Disorders, Neurologic; D006801:Humans; D008279:Magnetic Resonance Imaging; D010003:Osteoarthritis; D010019:Osteomyelitis; D014057:Tomography, X-Ray Computed | [
"D001850",
"D017719",
"D003929",
"D003937",
"D020233",
"D006801",
"D008279",
"D010003",
"D010019",
"D014057"
] | Is this bone infected or not? Differentiating neuro-osteoarthropathy from osteomyelitis in the diabetic foot. | Osteomyelitis (bone infection) and neuro-osteoarthropathy (Charcot arthropathy) are limb-threatening complications of diabetic neuropathy with very different therapies. Distinguishing between them may be difficult, but it is important. In Charcot arthropathy, noninfectious soft tissue inflammation accompanies rapidly p... | 1,240,841 | true | Is this bone infected or not? Differentiating neuro-osteoarthropathy from osteomyelitis in the diabetic foot. Osteomyelitis (bone infection) and neuro-osteoarthropathy (Charcot arthropathy) are limb-threatening complications of diabetic neuropathy with very different therapies. Distinguishing between them may be diffic... |
16,979,066 | D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases; D002544:Cerebral Infarction; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Ri... | [
"D000368",
"D000369",
"D002340",
"D002544",
"D005260",
"D006801",
"D007090",
"D008279",
"D008297",
"D008875",
"D011379",
"D015203",
"D018570",
"D012307",
"D055502",
"D012680"
] | Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study. | OBJECTIVE
We sought to test the hypothesis that magnetic resonance imaging (MRI)-defined vulnerable plaques correlate to accelerated reoccurrence of cerebrovascular events and to evaluate the potential use of MRI in secondary prevention of ischemic stroke.
METHODS
Fifty-three symptomatic participants were recruited f... | null | false | Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study. OBJECTIVE
We sought to test the hypothesis that magnetic resonance imaging (MRI)-defined vulnerable plaques correlate to accelerated reoccurrence of cerebrovascular events and to evaluate the poten... |
17,826,639 | D000800:Angioplasty, Balloon; D050197:Atherosclerosis; D016122:Brachiocephalic Trunk; D006801:Humans; D015607:Stents; D013348:Subclavian Artery; D014711:Vertebral Artery; D014715:Vertebrobasilar Insufficiency | [
"D000800",
"D050197",
"D016122",
"D006801",
"D015607",
"D013348",
"D014711",
"D014715"
] | Endovascular treatment of vertebral artery-origin and innominate/subclavian disease: indications and technique. | Approximately 20% to 40% of patients who have cerebral vascular disease have a vertebral artery-origin stenosis. Atherosclerotic lesions of vertebral arety origin are a potential cause of posterior circulation ischemia, which can be disabling or deadly. Endovascular treatment of vertebral artery-origin and innominate/s... | 12,600,087 | true | Endovascular treatment of vertebral artery-origin and innominate/subclavian disease: indications and technique. Approximately 20% to 40% of patients who have cerebral vascular disease have a vertebral artery-origin stenosis. Atherosclerotic lesions of vertebral arety origin are a potential cause of posterior circulatio... |
19,713,619 | D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D020127:Recovery of Function; D012149:Restraint, Physical; D012189:Retrospective Studies; D020521:Stroke; D0000719... | [
"D000203",
"D000328",
"D000368",
"D015331",
"D005081",
"D005260",
"D006801",
"D008297",
"D008875",
"D009043",
"D020127",
"D012149",
"D012189",
"D020521",
"D000071939",
"D016896"
] | Methods to improve constraint-induced movement therapy. | In global terms, cerebrovascular stroke is the leading cause of long-term disability. Despite improved acute phase management of stroke, the majority of survivors are disabled and many require effective rehabilitation. Constraint-induced movement therapy (CIMT) is one of the recently emerging therapies for subjects wit... | 11,400,196 | true | Methods to improve constraint-induced movement therapy. In global terms, cerebrovascular stroke is the leading cause of long-term disability. Despite improved acute phase management of stroke, the majority of survivors are disabled and many require effective rehabilitation. Constraint-induced movement therapy (CIMT) is... |
1,742,789 | D000368:Aged; D002423:Cause of Death; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease; D016757:Death, Sudden, Cardiac; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014481:United States | [
"D000368",
"D002423",
"D017023",
"D001026",
"D003327",
"D016757",
"D005260",
"D006801",
"D008297",
"D012189",
"D012307",
"D015996",
"D014481"
] | Predictors of early mortality in patients with angiographically documented left main coronary artery disease. | To determine predictors of early death after coronary angiography in patients with significant left main coronary artery disease (greater than or equal to 60% diameter narrowing, LMCAD), we reviewed the clinical records of patients with LMCAD who died after angiography. Of 1,288 patients with LMCAD studied between Janu... | 10,108,010 | true | Predictors of early mortality in patients with angiographically documented left main coronary artery disease. To determine predictors of early death after coronary angiography in patients with significant left main coronary artery disease (greater than or equal to 60% diameter narrowing, LMCAD), we reviewed the clinica... |
12,618,738 | D000208:Acute Disease; D000328:Adult; D001011:Aorta; D001021:Aortic Valve; D001024:Aortic Valve Stenosis; D002404:Catheterization; D003937:Diagnosis, Differential; D017548:Echocardiography, Transesophageal; D006406:Hematoma; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D012086:Reoperation; D013524... | [
"D000208",
"D000328",
"D001011",
"D001021",
"D001024",
"D002404",
"D003937",
"D017548",
"D006406",
"D006801",
"D008297",
"D011183",
"D012086",
"D013524",
"D013577",
"D014057",
"D017539"
] | Acute aortic intimal tear without a mobile flap mimicking an intramural hematoma. | Several variants of aortic pathology must be considered in the differential diagnosis of the patient presenting with an acute aortic syndrome. In addition to aortic dissection, such entities include intramural hematoma, penetrating aortic ulcer, and localized intimal tear without dissection. These lesions, which lack a... | 420,635 | true | Acute aortic intimal tear without a mobile flap mimicking an intramural hematoma. Several variants of aortic pathology must be considered in the differential diagnosis of the patient presenting with an acute aortic syndrome. In addition to aortic dissection, such entities include intramural hematoma, penetrating aortic... |
35,098,943 | D017023:Coronary Angiography; D003324:Coronary Artery Disease; D003331:Coronary Vessels; D006439:Hemodynamics; D006801:Humans; D058226:Plaque, Atherosclerotic; D041623:Tomography, Optical Coherence | [
"D017023",
"D003324",
"D003331",
"D006439",
"D006801",
"D058226",
"D041623"
] | Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression. | In this paper, we present a complete workflow for the biomechanical analysis of atherosclerotic plaque in the coronary vasculature. With atherosclerosis as one of the leading causes of global death, morbidity and economic burden, novel ways of analyzing and predicting its progression are needed. One such computational ... | 14,250,188 | true | Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression. In this paper, we present a complete workflow for the biomechanical analysis of atherosclerotic plaque in the coronary vasculature. With atherosclerosis as one of the leading causes of global d... |
31,698,256 | D000367:Age Factors; D000368:Aged; D001826:Body Fluids; D005260:Female; D020200:Hematoma, Subdural, Chronic; D006801:Humans; D002532:Intracranial Aneurysm; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011183:Postoperative Complications; D012372:ROC Curve; D012189:Retrospective Studies; D012307:... | [
"D000367",
"D000368",
"D001826",
"D005260",
"D020200",
"D006801",
"D002532",
"D008297",
"D008875",
"D019635",
"D011183",
"D012372",
"D012189",
"D012307",
"D013355",
"D007507",
"D014057"
] | Extensive postoperative subdural fluid volume affects the onset of chronic subdural hematoma after unruptured aneurysmal clipping surgery. | OBJECTIVE
To evaluate risk factors associated with chronic subdural hematoma (CSDH) onset after clipping surgery for unruptured intracranial aneurysm, and determine whether intraoperative conventional arachnoid-plasty (ARP) can suppress the CSDH onset by reducing subdural fluid volume.
METHODS
We retrospectively eval... | null | false | Extensive postoperative subdural fluid volume affects the onset of chronic subdural hematoma after unruptured aneurysmal clipping surgery. OBJECTIVE
To evaluate risk factors associated with chronic subdural hematoma (CSDH) onset after clipping surgery for unruptured intracranial aneurysm, and determine whether intraope... |
9,244,203 | D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D017963:Azithromycin; D015415:Biomarkers; D002690:Chlamydia Infections; D016993:Chlamydophila pneumoniae; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction | [
"D000284",
"D000368",
"D000900",
"D000907",
"D017963",
"D015415",
"D002690",
"D016993",
"D006801",
"D008297",
"D008875",
"D009203"
] | Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. | BACKGROUND
The clinical significance of the association between elevated anti-Chlamydia pneumoniae (Cp) antibody titres and coronary heart disease (CHD) is unclear. We explored the relationship between antibodies against Cp and future cardiovascular events in male survivors of myocardial infarction (MI). The effect of ... | null | false | Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. BACKGROUND
The clinical significance of the association between elevated anti-Chlamydia pneumoniae (Cp) antibody titres and coronary heart disease (CHD) is unclear. We explored the relationship ... |
15,815,910 | D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013997:Ti... | [
"D000368",
"D017023",
"D003324",
"D005260",
"D006801",
"D007091",
"D021621",
"D018810",
"D008297",
"D011446",
"D012680",
"D013997"
] | 3D motion adapted gating (3D MAG): a new navigator technique for accelerated acquisition of free breathing navigator gated 3D coronary MR-angiography. | This study aimed to evaluate the influence of a new navigator technique (3D MAG) on navigator efficiency, total acquisition time, image quality and diagnostic accuracy. Fifty-six patients with suspected coronary artery disease underwent free breathing navigator gated coronary MRA (Intera, Philips Medical Systems, 1.5 T... | 9,438,155 | true | 3D motion adapted gating (3D MAG): a new navigator technique for accelerated acquisition of free breathing navigator gated 3D coronary MR-angiography. This study aimed to evaluate the influence of a new navigator technique (3D MAG) on navigator efficiency, total acquisition time, image quality and diagnostic accuracy. ... |
21,725,749 | D000704:Analysis of Variance; D000818:Animals; D016227:Benzoquinones; D001921:Brain; D001929:Brain Edema; D001930:Brain Injuries; D002543:Cerebral Hemorrhage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors; D007839:Functional Laterality; D047029:Lactams, Macrocyclic;... | [
"D000704",
"D000818",
"D016227",
"D001921",
"D001929",
"D001930",
"D002543",
"D004195",
"D004305",
"D004791",
"D007839",
"D047029",
"D008297",
"D051379",
"D009422",
"D013997"
] | Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage. | We investigated the effect of the heat shock protein inducer geldanamycin on the development of secondary brain injury after ICH in mice. The effect of the drug at two different concentrations was evaluated at two time points: 24 and 72 h after ICH induction. In the first part of this study, a total of 30 male CD-1 mic... | 6,605,244 | true | Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage. We investigated the effect of the heat shock protein inducer geldanamycin on the development of secondary brain injury after ICH in mice. The effect of the drug at two different concentrations was evaluated at two time points: 24 and 72 h aft... |
18,044,341 | D000872:Anthocyanins; D001786:Blood Glucose; D001794:Blood Pressure; D016022:Case-Control Studies; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019332:Endothelin-1; D005260:Female; D006801:Humans; D006946:Hyperinsulinism; D006973:Hypertension; D008055:Lipids; D008074:Lipoproteins; D008297:Male; D024821:Metaboli... | [
"D000872",
"D001786",
"D001794",
"D016022",
"D008076",
"D008078",
"D019332",
"D005260",
"D006801",
"D006946",
"D006973",
"D008055",
"D008074",
"D008297",
"D024821",
"D008875",
"D046936",
"D010936",
"D014280",
"D049629"
] | [Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome]. | OBJECTIVE
To estimate the influence of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 (ET-1), serum lipids, fasting glucose, uric acid and membrane cholesterol in erythrocytes of patients (pts) with metabolic syndrome (MS).
METHODS
The study comprised 22 healthy volunteers and 2... | null | false | [Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome]. OBJECTIVE
To estimate the influence of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 (ET-1), serum lipids, fasting glucose, uric acid ... |
33,402,052 | D000200:Action Potentials; D000368:Aged; D004576:Electromyography; D005260:Female; D005542:Forearm; D006429:Hemiplegia; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves; D012189:Retrospective Studies; D012782:Shoulder; D020521:Stroke | [
"D000200",
"D000368",
"D004576",
"D005260",
"D005542",
"D006429",
"D006801",
"D008297",
"D008875",
"D009431",
"D010525",
"D012189",
"D012782",
"D020521"
] | Impact of shoulder subluxation on peripheral nerve conduction and function of hemiplegic upper extremity in stroke patients: A retrospective, matched-pair study. | Purpose: To investigate the impact of shoulder subluxation (SS) on peripheral nerve conduction and function of the hemiplegic upper extremity (HUE) in poststroke patients.Methods: Thirty post-stroke patients were selected (SS group: 15 patients, non-SS group: 15 patients, respectively). Evaluation of nerve conduction i... | null | false | Impact of shoulder subluxation on peripheral nerve conduction and function of hemiplegic upper extremity in stroke patients: A retrospective, matched-pair study. Purpose: To investigate the impact of shoulder subluxation (SS) on peripheral nerve conduction and function of the hemiplegic upper extremity (HUE) in poststr... |
7,713,923 | D000818:Animals; D001779:Blood Coagulation Factors; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002417:Cattle; D003328:Coronary Thrombosis; D004285:Dogs; D004730:Endothelium, Vascular; D008168:Lung; D051379:Mice; D008954:Models, Biological; D009569:Nitric Oxide; D011994:Recombinant Proteins; D012261:Ribonu... | [
"D000818",
"D001779",
"D002135",
"D037282",
"D002417",
"D003328",
"D004285",
"D004730",
"D008168",
"D051379",
"D008954",
"D009569",
"D011994",
"D012261",
"D014812"
] | Calreticulin, an antithrombotic agent which binds to vitamin K-dependent coagulation factors, stimulates endothelial nitric oxide production, and limits thrombosis in canine coronary arteries. | Coagulation Factor IX/IXa has been shown to bind to cellular surfaces, and Factor IXa expresses its procoagulant activity by assembling into the intrinsic Factor X activating complex (Factors IXa/VIIIa/X), which also forms on membrane surfaces. This led us to identify cellular proteins which bind Factor IX/IXa; an appr... | 12,695,137 | true | Calreticulin, an antithrombotic agent which binds to vitamin K-dependent coagulation factors, stimulates endothelial nitric oxide production, and limits thrombosis in canine coronary arteries. Coagulation Factor IX/IXa has been shown to bind to cellular surfaces, and Factor IXa expresses its procoagulant activity by as... |
2,142,517 | D000368:Aged; D001157:Arterial Occlusive Diseases; D001366:Axillary Artery; D001807:Blood Vessel Prosthesis; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007866:Leg; D008297:Male; D011093:Polyethylene Terephthalates | [
"D000368",
"D001157",
"D001366",
"D001807",
"D005260",
"D005263",
"D006801",
"D007866",
"D008297",
"D011093"
] | [Extra-anatomical bypasses: axillofemoral and femorofemoral. Indications and results]. | Indications for a unilateral or bilateral axillofemoral and femorofemoral bypass, are presented. Our experience in 48 patients with axillofemoral and femorofemoral form the basis of this report. Indications for these extended bypasses included suppurative growing infection and obliterated common and profunda femoris ar... | null | false | [Extra-anatomical bypasses: axillofemoral and femorofemoral. Indications and results]. Indications for a unilateral or bilateral axillofemoral and femorofemoral bypass, are presented. Our experience in 48 patients with axillofemoral and femorofemoral form the basis of this report. Indications for these extended bypasse... |
66,844 | D000818:Animals; D002462:Cell Membrane; D003593:Cytoplasm; D004285:Dogs; D006651:Histocytochemistry; D006801:Humans; D051379:Mice; D009203:Myocardial Infarction; D009206:Myocardium; D009336:Necrosis; D011509:Proteoglycans; D013194:Staining and Labeling | [
"D000818",
"D002462",
"D003593",
"D004285",
"D006651",
"D006801",
"D051379",
"D009203",
"D009206",
"D009336",
"D011509",
"D013194"
] | [Ultrastructure of the contact between interstitial cells and myocardial cells in mammalian hearts]. | By combination of light, electron-microscopical and histochemical findings in the myocardium of dog and mice, the hypothesis of an intimate contact between a widely branched interstitial cell type, rich in proteoglycans, and myocardial cells could be strengthened. The branches seem to penetrate the transversal tubular ... | null | false | [Ultrastructure of the contact between interstitial cells and myocardial cells in mammalian hearts]. By combination of light, electron-microscopical and histochemical findings in the myocardium of dog and mice, the hypothesis of an intimate contact between a widely branched interstitial cell type, rich in proteoglycans... |
35,383,106 | D000328:Adult; D015331:Cohort Studies; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies | [
"D000328",
"D015331",
"D005260",
"D006330",
"D006801",
"D007362",
"D007902",
"D008297",
"D012189"
] | Adult patients with congenital heart disease in the intensive care unit. | Current data on intensive care unit (ICU) admissions in patients with adult congenital heart disease (ACHD) are limited and focus on admissions after elective cardiac surgery. This study describes non-elective ICU admissions in patients with ACHD.
A retrospective matched cohort study was performed from January 2000 ... | null | false | Adult patients with congenital heart disease in the intensive care unit. Current data on intensive care unit (ICU) admissions in patients with adult congenital heart disease (ACHD) are limited and focus on admissions after elective cardiac surgery. This study describes non-elective ICU admissions in patients with ACHD.... |
10,589,546 | D000328:Adult; D004272:DNA, Mitochondrial; D042967:Electron Transport Complex I; D003576:Electron Transport Complex IV; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017241:MELAS Syndrome; D008297:Male; D008931:Mitochondria, Muscle; D018482:Muscle, Skeletal; D009247:NADH, NADPH Oxidoreduct... | [
"D000328",
"D004272",
"D042967",
"D003576",
"D005260",
"D020022",
"D006801",
"D017241",
"D008297",
"D008931",
"D018482",
"D009247",
"D015418",
"D017354",
"D016133"
] | The mitochondrial DNA G13513A transition in ND5 is associated with a LHON/MELAS overlap syndrome and may be a frequent cause of MELAS. | We report on 4 male patients with clinical, radiological, and muscle biopsy findings typical of the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenotype. Skeletal muscle mitochondrial DNA (mtDNA) analysis showed that all patients harbored a heteroplasmic G13513A mutation in th... | 14,240,577 | true | The mitochondrial DNA G13513A transition in ND5 is associated with a LHON/MELAS overlap syndrome and may be a frequent cause of MELAS. We report on 4 male patients with clinical, radiological, and muscle biopsy findings typical of the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS)... |
30,014,299 | D000208:Acute Disease; D000328:Adult; D000368:Aged; D000925:Anticoagulants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D012008:Recurrence; D012307:Risk Factors; D014463:Ultrasonography; D054556:Venous Thromboembolism; D020246:Venous Thrombosis | [
"D000208",
"D000328",
"D000368",
"D000925",
"D005260",
"D006801",
"D008297",
"D008875",
"D009369",
"D012008",
"D012307",
"D014463",
"D054556",
"D020246"
] | Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer. | After acute proximal deep vein thrombosis (DVT) the thrombotic mass decreases, especially during the first months of anticoagulation. The persistence of residual vein obstruction (RVO) may predict future recurrence in patients with cancer-associated DVT. We aimed to evaluate the proportion of patients with RVO after an... | null | false | Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer. After acute proximal deep vein thrombosis (DVT) the thrombotic mass decreases, especially during the first months of anticoagulation. The persistence of residual vein obstruction (RVO) may pred... |
26,492,183 | D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D016543:Central Nervous System Neoplasms; D002675:Child, Preschool; D016371:Cranial Irradiation; D042783:Endothelial Cells; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875... | [
"D000328",
"D000368",
"D014408",
"D016543",
"D002675",
"D016371",
"D042783",
"D005260",
"D006801",
"D006965",
"D007150",
"D008279",
"D008297",
"D008875",
"D009381",
"D012307",
"D013997",
"D014057",
"D015534",
"D000071230",
"D019043"
] | CNS Masson Tumors: Frequent Association With Therapeutic Radiation. | Masson tumor (MT, papillary endothelial hyperplasia) is an exaggerated form of thrombus reorganization rarely occurring in the central nervous system (CNS), where it presents as a mass or hemorrhage in parenchyma, meninges, or venous sinuses. MT is subclassified as type 1 arising within a histologically normal vessel, ... | 7,298,933 | true | CNS Masson Tumors: Frequent Association With Therapeutic Radiation. Masson tumor (MT, papillary endothelial hyperplasia) is an exaggerated form of thrombus reorganization rarely occurring in the central nervous system (CNS), where it presents as a mass or hemorrhage in parenchyma, meninges, or venous sinuses. MT is sub... |
25,680,403 | D000368:Aged; D003097:Collateral Circulation; D023921:Coronary Stenosis; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012737:Sex Factors | [
"D000368",
"D003097",
"D023921",
"D003920",
"D005260",
"D006801",
"D008297",
"D008875",
"D012720",
"D012737"
] | Diabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosis. | BACKGROUND
Coronary collateral vessel development (CVD), i.e., arteriogenesis, is regarded as one of the most important mechanisms—along with angiogenesis—to result in protection of the myocardium. Coronary CVD is associated with a reduction in infarct size, future cardiovascular events and improved survival in patient... | null | false | Diabetes mellitus and female gender are the strongest predictors of poor collateral vessel development in patients with severe coronary artery stenosis. BACKGROUND
Coronary collateral vessel development (CVD), i.e., arteriogenesis, is regarded as one of the most important mechanisms—along with angiogenesis—to result in... |
17,919,623 | D000818:Animals; D001706:Biopsy; D004699:Endocardium; D006084:Graft Rejection; D006085:Graft Survival; D016027:Heart Transplantation; D006352:Heart Ventricles; D007150:Immunohistochemistry; D017202:Myocardial Ischemia; D009206:Myocardium; D010215:Papio; D013552:Swine; D013997:Time Factors; D014183:Transplantation, Hete... | [
"D000818",
"D001706",
"D004699",
"D006084",
"D006085",
"D016027",
"D006352",
"D007150",
"D017202",
"D009206",
"D010215",
"D013552",
"D013997",
"D014183",
"D016042"
] | The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation. | BACKGROUND
Endomyocardial biopsy is the standard means of establishing cardiac allograft rejection diagnosis. The efficacy of this procedure in xenotransplantation has not been determined. In this study we compare the histology of right ventricular endomyocardial biopsy specimens with the corresponding full cross secti... | null | false | The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation. BACKGROUND
Endomyocardial biopsy is the standard means of establishing cardiac allograft rejection diagnosis. The efficacy of this procedure in xenotransplantation has not be... |
17,186,981 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020517:Atrial Appendage; D001281:Atrial Fibrillation; D001344:Autopsy; D016022:Case-Control Studies; D005260:Female; D006325:Heart Atria; D006349:Heart Valve Diseases; D006801:Humans; D008297:Male; D008875:Middle Aged; D032383:Myocytes, Cardiac; D011237:Predictiv... | [
"D000328",
"D000368",
"D000369",
"D020517",
"D001281",
"D001344",
"D016022",
"D005260",
"D006325",
"D006349",
"D006801",
"D008297",
"D008875",
"D032383",
"D011237",
"D012008"
] | Histopathological features of the resected left atrial appendage as predictors of recurrence after surgery for atrial fibrillation in valvular heart disease. | BACKGROUND
A histopathological assessment of left atrial appendages (LAA) resected during surgical treatment for atrial fibrillation (AF) was made, with the aim of improving the prediction of postoperative AF recurrence.
RESULTS
This clinicopathological study involved 57 surgical cases of valvular AF and 34 age- and ... | null | false | Histopathological features of the resected left atrial appendage as predictors of recurrence after surgery for atrial fibrillation in valvular heart disease. BACKGROUND
A histopathological assessment of left atrial appendages (LAA) resected during surgical treatment for atrial fibrillation (AF) was made, with the aim o... |
29,885,463 | D000368:Aged; D050197:Atherosclerosis; D001483:Base Sequence; D016022:Case-Control Studies; D003324:Coronary Artery Disease; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Si... | [
"D000368",
"D050197",
"D001483",
"D016022",
"D003324",
"D005260",
"D005787",
"D056726",
"D020022",
"D006801",
"D008297",
"D008875",
"D020641",
"D012189",
"D012307",
"D056564"
] | SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease. | Coronary artery disease (CAD) exhibits the rules of the multifactorial hereditary. Notwithstanding, the role of genetic factors in the prevalence of CAD is estimated very high. SIRT1 plays an athero-protective role and alterations in its expression have some important consequence in the metabolism, cholesterol, and fat... | 11,083,974 | true | SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease. Coronary artery disease (CAD) exhibits the rules of the multifactorial hereditary. Notwithstanding, the role of genetic factors in the prevalence of CAD is estimated very high. SIRT1 plays an athero-protective role and a... |
26,621,978 | D062186:Arterial Pressure; D019985:Benchmarking; D062906:Cardiac Catheters; D002407:Catheterization, Swan-Ganz; D003951:Diagnostic Errors; D004867:Equipment Design; D006801:Humans; D006976:Hypertension, Pulmonary; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011379:Prognosis; D011651:Pulmon... | [
"D062186",
"D019985",
"D062906",
"D002407",
"D003951",
"D004867",
"D006801",
"D006976",
"D017410",
"D011237",
"D011379",
"D011651",
"D011669",
"D015203",
"D014160"
] | Right heart catheterisation: best practice and pitfalls in pulmonary hypertension. | Right heart catheterisation (RHC) plays a central role in identifying pulmonary hypertension (PH) disorders, and is required to definitively diagnose pulmonary arterial hypertension (PAH). Despite widespread acceptance, there is a lack of guidance regarding the best practice for performing RHC in clinical practice. In ... | 10,650,360 | true | Right heart catheterisation: best practice and pitfalls in pulmonary hypertension. Right heart catheterisation (RHC) plays a central role in identifying pulmonary hypertension (PH) disorders, and is required to definitively diagnose pulmonary arterial hypertension (PAH). Despite widespread acceptance, there is a lack o... |
8,418,737 | D000818:Animals; D003097:Collateral Circulation; D003327:Coronary Disease; D004285:Dogs; D005260:Female; D006321:Heart; D006439:Hemodynamics; D007275:Injections, Intravenous; D008297:Male; D015742:Propofol | [
"D000818",
"D003097",
"D003327",
"D004285",
"D005260",
"D006321",
"D006439",
"D007275",
"D008297",
"D015742"
] | Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium. | To examine the effects of propofol on the function of normal, collateral-dependent, and acutely ischemic myocardium, nine mongrel dogs were chronically instrumented with hydraulic occluders and ameroid constrictors were inserted around the left coronary artery, pressure transducers in the left ventricle, and heparin-fi... | 6,549,262 | true | Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium. To examine the effects of propofol on the function of normal, collateral-dependent, and acutely ischemic myocardium, nine mongrel dogs were chronically instrumented with hydraulic occluders and ameroid constrictors were insert... |
8,571,038 | D017130:Angioplasty; D000075202:Contraindications; D006801:Humans; D009203:Myocardial Infarction; D015425:Myocardial Reperfusion; D015912:Thrombolytic Therapy; D014654:Vascular Patency | [
"D017130",
"D000075202",
"D006801",
"D009203",
"D015425",
"D015912",
"D014654"
] | [Coronary recanalization in the acute phase of myocardial infarction]. | Early reopening of the infarct-related artery limits infarct size, preserves left ventricular function and reduces short and long term mortality rate. The earlier the reopening, the higher the benefit, the best results being obtained within the first 3 hours, but remaining significant up to 12 hours after onset of symp... | null | false | [Coronary recanalization in the acute phase of myocardial infarction]. Early reopening of the infarct-related artery limits infarct size, preserves left ventricular function and reduces short and long term mortality rate. The earlier the reopening, the higher the benefit, the best results being obtained within the firs... |
24,559,419 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013119:Spinal Cord Injuries | [
"D000328",
"D000368",
"D000369",
"D001145",
"D004562",
"D005260",
"D006801",
"D008297",
"D008875",
"D011446",
"D013119"
] | Cardiac arrhythmias the first month after acute traumatic spinal cord injury. | OBJECTIVE
Cardiovascular complications including cardiac arrest and arrhythmias remain a clinical challenge in the management of acute traumatic spinal cord injury (SCI). Still, there is a lack of knowledge regarding the characteristics of arrhythmias in patients with acute traumatic SCI. The aim of this prospective ob... | null | false | Cardiac arrhythmias the first month after acute traumatic spinal cord injury. OBJECTIVE
Cardiovascular complications including cardiac arrest and arrhythmias remain a clinical challenge in the management of acute traumatic spinal cord injury (SCI). Still, there is a lack of knowledge regarding the characteristics of ar... |
25,234,602 | D000464:Alginates; D000704:Analysis of Variance; D000818:Animals; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D004195:Disease Models, Animal; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D020723:Glucuronic Acid; D006329:Heart Conduction Sy... | [
"D000464",
"D000704",
"D000818",
"D018929",
"D002478",
"D004195",
"D015150",
"D004562",
"D022062",
"D020723",
"D006329",
"D006603",
"D020136",
"D045164",
"D018613",
"D009203",
"D011897",
"D012016",
"D013552",
"D016896"
] | Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. | BACKGROUND
Mesenchymal stem cells (MSCs) have been associated with reduced arrhythmias; however, the mechanism of this action is unknown. In addition, limited retention and survival of MSCs can significantly reduce efficacy. We hypothesized that MSCs can improve impulse conduction and that alginate hydrogel will enhanc... | null | false | Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. BACKGROUND
Mesenchymal stem cells (MSCs) have been associated with reduced arrhythmias; however, the mechanism of this action is unknown. In addition, limited retention and survival of MSCs can sig... |
8,619,673 | D000368:Aged; D003323:Coronary Aneurysm; D017023:Coronary Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male | [
"D000368",
"D003323",
"D017023",
"D006801",
"D008279",
"D008297"
] | Surgical treatment of multiple coronary aneurysms in an elderly man. | We report an unusual case involving a 70-year-old man with multiple coronary aneurysms, including a 5-cm aneurysm of the right coronary artery. The precise size was determined with magnetic resonance imaging, although the aneurysms were diagnosed initially on angiography. Multiple coronary aneurysms are rare in adults,... | 9,225,316 | true | Surgical treatment of multiple coronary aneurysms in an elderly man. We report an unusual case involving a 70-year-old man with multiple coronary aneurysms, including a 5-cm aneurysm of the right coronary artery. The precise size was determined with magnetic resonance imaging, although the aneurysms were diagnosed init... |
27,354,043 | D003327:Coronary Disease; D054855:Drug-Eluting Stents; D000068338:Everolimus; D006801:Humans; D009543:Nifedipine; D011446:Prospective Studies; D020123:Sirolimus; D016896:Treatment Outcome | [
"D003327",
"D054855",
"D000068338",
"D006801",
"D009543",
"D011446",
"D020123",
"D016896"
] | Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation: The NOVEL study. | It is widely known that drug-eluting stents (DES) induce coronary vasomotion abnormalities. We have previously demonstrated that chronic treatment with long-acting nifedipine suppresses coronary hyperconstricting responses induced by the first-generation DES (e.g. sirolimus- and pacritaxel-eluting stents) through inhib... | null | false | Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation: The NOVEL study. It is widely known that drug-eluting stents (DES) induce coronary vasomotion abnormalities. We have previously demonstrated that chronic treatment with long-acting nifedipine suppres... |
20,168,272 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy; D005260:Female; D005451:Fluorescein Angiography; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D054023:Lasers, Semiconductor; D008269:Macular Edema; D008297:Male; D008875:Middle Aged; D011446:P... | [
"D000328",
"D000368",
"D000369",
"D003930",
"D005260",
"D005451",
"D005453",
"D005654",
"D006801",
"D017075",
"D054023",
"D008269",
"D008297",
"D008875",
"D011446",
"D012160",
"D041623",
"D016896",
"D014792",
"D058609",
"D014794"
] | Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation. | OBJECTIVE
The purpose of this study was to evaluate and compare microperimetry and fundus autofluorescence (FAF) after subthreshold micropulse diode laser versus modified Early Treatment Diabetic Retinopathy Study photocoagulation for clinically significant diabetic macular edema.
METHODS
A prospective randomized cli... | null | false | Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation. OBJECTIVE
The purpose of this study was to evaluate and compare microperimetry and fundus autofluorescence (FAF) after subthreshold... |
20,739,902 | D000328:Adult; D001024:Aortic Valve Stenosis; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles; D017052:Hospital Mortality; D006801:Humans; D007194:India; D008297:Male; D008875:Middle... | [
"D000328",
"D001024",
"D016009",
"D015150",
"D005260",
"D006350",
"D019918",
"D006352",
"D017052",
"D006801",
"D007194",
"D008297",
"D008875",
"D011474",
"D012189",
"D018570",
"D012307",
"D013997",
"D016896",
"D016277"
] | A comparative study of surgical treatment of small aortic root with or without aortic root enlargement using a single prosthesis type. | BACKGROUND
The ideal management of aortic stenosis in patients with a small aortic root remains controversial. Reports of adverse effects of patient-prosthesis mismatch (PPM) from a small-sized valve have to be weighed against the increased morbidity and mortality of aortic root enlargement procedures.
METHODS
The pr... | null | false | A comparative study of surgical treatment of small aortic root with or without aortic root enlargement using a single prosthesis type. BACKGROUND
The ideal management of aortic stenosis in patients with a small aortic root remains controversial. Reports of adverse effects of patient-prosthesis mismatch (PPM) from a sma... |
1,389,854 | D000208:Acute Disease; D000328:Adult; D000707:Anaphylaxis; D005260:Female; D006801:Humans; D007022:Hypotension; D007431:Intraoperative Complications; D008303:Malignant Carcinoid Syndrome; D013390:Succinylcholine | [
"D000208",
"D000328",
"D000707",
"D005260",
"D006801",
"D007022",
"D007431",
"D008303",
"D013390"
] | Anaphylactoid or carcinoid? | A patient with a carcinoid tumour and a history suggestive of carcinoid syndrome, but with no biochemical evidence in support, had a cardiovascular collapse during an anaesthetic with propofol and suxamethonium. Subsequent investigations suggested an anaphylactoid reaction to suxamethonium, but there were features in c... | 13,608,746 | true | Anaphylactoid or carcinoid? A patient with a carcinoid tumour and a history suggestive of carcinoid syndrome, but with no biochemical evidence in support, had a cardiovascular collapse during an anaesthetic with propofol and suxamethonium. Subsequent investigations suggested an anaphylactoid reaction to suxamethonium, ... |
7,142,822 | D000368:Aged; D000783:Aneurysm; D001014:Aortic Aneurysm; D001027:Aortography; D001161:Arteriosclerosis; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007083:Iliac Artery; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery | [
"D000368",
"D000783",
"D001014",
"D001027",
"D001161",
"D005260",
"D005263",
"D006801",
"D007083",
"D008297",
"D008875",
"D011150"
] | [Arteriomegaly. Apropos of 6 cases]. | Six cases of megalodolichoartery (M. D. A.) or arteriomegaly are reported. The arteriographic characteristics of the condition are reviewed: abnormally dilated and tortuous arteries, frequently aneurysmal, sometimes the site of obstruction by obliterative arteriosclerosis or embolism. Although clinically the relation b... | null | false | [Arteriomegaly. Apropos of 6 cases]. Six cases of megalodolichoartery (M. D. A.) or arteriomegaly are reported. The arteriographic characteristics of the condition are reviewed: abnormally dilated and tortuous arteries, frequently aneurysmal, sometimes the site of obstruction by obliterative arteriosclerosis or embolis... |
31,864,875 | D054058:Acute Coronary Syndrome; D015415:Biomarkers; D003937:Diagnosis, Differential; D004562:Electrocardiography; D004635:Emergency Medicine; D006331:Heart Diseases; D006801:Humans; D009203:Myocardial Infarction; D011655:Pulmonary Embolism; D018805:Sepsis; D020521:Stroke; D014336:Troponin | [
"D054058",
"D015415",
"D003937",
"D004562",
"D004635",
"D006331",
"D006801",
"D009203",
"D011655",
"D018805",
"D020521",
"D014336"
] | An emergency medicine approach to troponin elevation due to causes other than occlusion myocardial infarction. | Troponin is an integral component of the evaluation for acute coronary syndrome (ACS) and occlusion myocardial infarction (OMI). However, troponin may be elevated in conditions other than OMI.
This narrative review provides emergency clinicians with a focused evaluation of troponin elevation in patients with myocard... | null | false | An emergency medicine approach to troponin elevation due to causes other than occlusion myocardial infarction. Troponin is an integral component of the evaluation for acute coronary syndrome (ACS) and occlusion myocardial infarction (OMI). However, troponin may be elevated in conditions other than OMI.
This narrativ... |
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