instruction stringlengths 142 1.78k | input stringlengths 321 1.59k | response stringclasses 11 values |
|---|---|---|
<Instruct>: Given the context 'Sequences and use of PCR primers
a: 5′-CCCCGGCCCTCACCCTCATCTTCG-3′, from the PuΔTK gene, assays targeting of Flox plasmid; b: 5′-AACAAAACAAAACAGCAGCAACAA-3′, from sequences downstream of the p53 gene and outside Flox sequences, assays targeting of Flox and RMCE with p53GFP or p53ΔPGFP plasmids; c: 5′-TGAAGAGCAAGGGCGTGGTGAAGGA-3′, from GFP sequences, assays RMCE with p53GFP orp53ΔPGFP plasmids; d: 5′-CAAAAAATGGAAGGAAATCAGGAACTAA-3′, from p53 intron 3, and e: 5′-TCTAGACAGAGAAAAAAGAGGCATT-3′, from p53 intron 4, assay RMCE with p53ΔPGFP plasmid; f: 5′-ATGGGAGGCTGCCAGTCCTAACCC and g: 5′-GTGTTTCATTAGTTCCCCACCTTGAC-3′ amplify the WT p53 allele according to Taconic's procedures,', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: adenylyl cyclase 9 (aka adenylate cyclase type 9)
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'h: 5′-TTTACGGAGCCCTGGCGCTCGATGT-3′ and i: 5′-GTGGGAGGGACAAAAGTTCGAGGCC-3′ amplify the Neo marker in the p53 KO allele according to Taconic's procedures.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcy9 (aka adenylate cyclase type 9)
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Performing RMCE in ES cells
A total of 8 × 105 p53RMCE/+ ES cells were grown without puromycin for 12 h, electroporated with 15 μg CMV-Cre plasmid (pOG231) and 200 μg of the exchange construct, and plated in T25 flasks at 105 cells per flask.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: actp10 (aka adenylate cyclase type 9)
H: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'Performing RMCE in MEFs
A total of 106 p53RMCE/− MEFs cells were grown without puromycin for 12 h, electroporated with 3 μg pOG231 and 30 μg exchange construct, and plated in a single 10 cm-dish, grown for 3 days then split in several dishes at 105 cells per dish.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Blots were incubated in 5% non-fat dried milk in TBST (0.02 M Tris, pH 7.6/0.35 M NaCl/0.1% Tween-20) for 1 h at room temperature before probing with primary antibodies against p53 (CM-5, Novacastra) and -actin (Sigma).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: kiaa0520 (aka adenylate cyclase type 9)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'We next tested the efficiency of RMCE in ES cells, using a replacement construct encoding p53 fused to GFP (p53GFP) to enable tracking p53 in individual live cells.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: adenylyl cyclase 9 (aka adenylate cyclase type 9)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We next tested the efficiency of RMCE in ES cells, using a replacement construct encoding p53 fused to GFP (p53GFP) to enable tracking p53 in individual live cells.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: adenylyl cyclase 9 (aka adenylate cyclase type 9)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We next tested the efficiency of RMCE in ES cells, using a replacement construct encoding p53 fused to GFP (p53GFP) to enable tracking p53 in individual live cells.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'p53+/GFP ES clones were analyzed by western blot with an antibody against p53, and found to express an additional band at the expected size (ca. 80 kDa).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: pacap (aka pituitary adenylate cyclase-activating polypeptide)
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'p53+/GFP ES clones were analyzed by western blot with an antibody against p53, and found to express an additional band at the expected size (ca. 80 kDa).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: actp10 (aka adenylate cyclase type 9)
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: adcy9 (aka adenylate cyclase type 9)
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: actp10 (aka adenylate cyclase type 9)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: pacap (aka pituitary adenylate cyclase-activating polypeptide)
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: ec-motb (aka motility protein b (escherichia coli k-12))
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: kiaa0520 (aka adenylate cyclase type 9)
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: adcy9 (aka adenylate cyclase type 9)
D: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: kiaa0520 (aka adenylate cyclase type 9)
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Surprisingly, the fusion of GFP to p53 apparently altered p53 stability: steady-state levels of p53GFP were much higher than those of wild-type p53 (p53WT) in unstressed cells, and did not vary significantly after DNA damage, so that the levels for both p53WT and p53GFP were similar after adriamycin treatment (Figure 3A).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: adenylyl cyclase 9 (aka adenylate cyclase type 9)
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Six independent p53+/GFP clones were injected into blastocysts and transferred to pseudo-pregnant females using standard procedures.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: adcy9 (aka adenylate cyclase type 9)
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'It has been shown that the p53 pathway is regulated very differently in ES and somatic cells: ES cells contain relatively high p53 levels and lack the p53-mediated DNA damage responses found in somatic cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: adenylyl cyclase 9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'It has been shown that the p53 pathway is regulated very differently in ES and somatic cells: ES cells contain relatively high p53 levels and lack the p53-mediated DNA damage responses found in somatic cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: actp10 (aka adenylate cyclase type 9)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: pacap (aka pituitary adenylate cyclase-activating polypeptide)
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'It has been shown that the p53 pathway is regulated very differently in ES and somatic cells: ES cells contain relatively high p53 levels and lack the p53-mediated DNA damage responses found in somatic cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
F: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'This, together with the observation that p53 levels decrease during mouse embryogenesis (19), suggested an explanation for the observed lack of pregnancies: we speculate that the high levels of p53GFP in the ES cells injected into blastocysts might have prevented normal embryonic development once these cells began to differentiate and the p53 pathway became functional.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: adcy9 (aka adenylate cyclase type 9)
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'This, together with the observation that p53 levels decrease during mouse embryogenesis (19), suggested an explanation for the observed lack of pregnancies: we speculate that the high levels of p53GFP in the ES cells injected into blastocysts might have prevented normal embryonic development once these cells began to differentiate and the p53 pathway became functional.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: actp10 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'This, together with the observation that p53 levels decrease during mouse embryogenesis (19), suggested an explanation for the observed lack of pregnancies: we speculate that the high levels of p53GFP in the ES cells injected into blastocysts might have prevented normal embryonic development once these cells began to differentiate and the p53 pathway became functional.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: pacap (aka pituitary adenylate cyclase-activating polypeptide)
C: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: actp10 (aka adenylate cyclase type 9)
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, we performed RMCE with a p53 fusion gene in which the p53 proline-rich domain (PRD) was deleted (p53ΔP), and the p53ΔP was fused to GFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, we performed RMCE with a p53 fusion gene in which the p53 proline-rich domain (PRD) was deleted (p53ΔP), and the p53ΔP was fused to GFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: kiaa0520 (aka adenylate cyclase type 9)
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: pacap (aka pituitary adenylate cyclase-activating polypeptide)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, we performed RMCE with a p53 fusion gene in which the p53 proline-rich domain (PRD) was deleted (p53ΔP), and the p53ΔP was fused to GFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: kiaa0520 (aka adenylate cyclase type 9)
I: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, we performed RMCE with a p53 fusion gene in which the p53 proline-rich domain (PRD) was deleted (p53ΔP), and the p53ΔP was fused to GFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: pacap (aka pituitary adenylate cyclase-activating polypeptide)
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'RMCE with a p53ΔPGFP replacement plasmid was again very efficient and western blots revealed an additional band of the predicted molecular weight only in p53+/ΔPGFP ES cells (Figure 3B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: adcy9 (aka adenylate cyclase type 9)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'RMCE with a p53ΔPGFP replacement plasmid was again very efficient and western blots revealed an additional band of the predicted molecular weight only in p53+/ΔPGFP ES cells (Figure 3B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: kiaa0520 (aka adenylate cyclase type 9)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'As expected, the PRD deletion correlated with lower expression levels: p53ΔPGFP was much less abundant than p53WT in all p53+/ΔPGFP clones (Figure 3B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'As expected, the PRD deletion correlated with lower expression levels: p53ΔPGFP was much less abundant than p53WT in all p53+/ΔPGFP clones (Figure 3B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: actp10 (aka adenylate cyclase type 9)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'As expected, the PRD deletion correlated with lower expression levels: p53ΔPGFP was much less abundant than p53WT in all p53+/ΔPGFP clones (Figure 3B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: kiaa0520 (aka adenylate cyclase type 9)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We next determined whether p53+/ΔPGFP ES cells could generate chimeric mice and transmit the modified allele through the germline.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ec-motb (aka motility protein b (escherichia coli k-12))
E: adcy9 (aka adenylate cyclase type 9)
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Two p53+/ΔPGFP ES cell clones were injected into blastocysts and highly chimeric (>80%) mice were obtained.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: ec-motb (aka motility protein b (escherichia coli k-12))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'We next determined whether the RMCE approach could be used to target mutations at the p53 allele in somatic cells (Figure 1, path B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: kiaa0520 (aka adenylate cyclase type 9)
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We first verified that the RMCE-ready p53 locus (p53RMCE) could be transmitted through the germline by mating p53RMCE/+ chimeras with p53+/− mice (20) (Figure 4).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: adcy9 (aka adenylate cyclase type 9)
C: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We first verified that the RMCE-ready p53 locus (p53RMCE) could be transmitted through the germline by mating p53RMCE/+ chimeras with p53+/− mice (20) (Figure 4).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: actp10 (aka adenylate cyclase type 9)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'We first verified that the RMCE-ready p53 locus (p53RMCE) could be transmitted through the germline by mating p53RMCE/+ chimeras with p53+/− mice (20) (Figure 4).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We first verified that the RMCE-ready p53 locus (p53RMCE) could be transmitted through the germline by mating p53RMCE/+ chimeras with p53+/− mice (20) (Figure 4).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: adcy9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Importantly, this allowed us to generate p53RMCE/− MEFs, which were used to test RMCE at the p53 locus in somatic cells.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: adenylyl cyclase 9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'Importantly, this allowed us to generate p53RMCE/− MEFs, which were used to test RMCE at the p53 locus in somatic cells.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: adenylyl cyclase 9 (aka adenylate cyclase type 9)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'We first attempted RMCE in MEFs by electroporating p53RMCE/− MEFs with a Cre-expression plasmid and the p53GFP plasmid, followed by selection with FIAU or ganciclovir.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: kiaa0520 (aka adenylate cyclase type 9)
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'We first attempted RMCE in MEFs by electroporating p53RMCE/− MEFs with a Cre-expression plasmid and the p53GFP plasmid, followed by selection with FIAU or ganciclovir.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: actp10 (aka adenylate cyclase type 9)
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'RMCE with p53GFP in ES cells showed that p53GFP is expressed at high levels (Figure 3A), and as mentioned before, the p53 pathway that can be activated in MEFs is not readily activated in ES cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: kiaa0520 (aka adenylate cyclase type 9)
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'RMCE with p53GFP in ES cells showed that p53GFP is expressed at high levels (Figure 3A), and as mentioned before, the p53 pathway that can be activated in MEFs is not readily activated in ES cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
F: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: adcy9 (aka adenylate cyclase type 9)
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'RMCE with p53GFP in ES cells showed that p53GFP is expressed at high levels (Figure 3A), and as mentioned before, the p53 pathway that can be activated in MEFs is not readily activated in ES cells (18).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: adcy9 (aka adenylate cyclase type 9)
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'The results above suggest that high levels of p53GFP could be tolerated by ES cells but toxic to MEFs, so that MEFs in which an RMCE had occurred failed to proliferate.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: adcy9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, p53RMCE/− MEFs were electroporated with the p53GFP replacement construct with or without a Cre-expression plasmid, then analyzed by fluorescence microscopy 48 h after electroporation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'To test this possibility, p53RMCE/− MEFs were electroporated with the p53GFP replacement construct with or without a Cre-expression plasmid, then analyzed by fluorescence microscopy 48 h after electroporation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: adcy9 (aka adenylate cyclase type 9)
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'The experiment was done without selection to enable observation of cells under conditions where a failure to proliferate would not derive from FIAU or ganciclovir toxicity but rather solely from the effects of p53GFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: actp10 (aka adenylate cyclase type 9)
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Altogether, the results suggest that RMCE can give rise to p53GFP-expressing MEFs, but they die rapidly owing to p53GFP toxicity.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: kiaa0520 (aka adenylate cyclase type 9)
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'Altogether, the results suggest that RMCE can give rise to p53GFP-expressing MEFs, but they die rapidly owing to p53GFP toxicity.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-motb (aka motility protein b (escherichia coli k-12))
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: adenylyl cyclase 9 (aka adenylate cyclase type 9)
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We also performed RMCE in p53RMCE/− MEFs with the p53ΔPGFP construct.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'We also performed RMCE in p53RMCE/− MEFs with the p53ΔPGFP construct.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: kiaa0520 (aka adenylate cyclase type 9)
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'p53ΔPGFP-expressing MEFs were viable, recovered with an efficiency of ∼40%, and, as expected from ES cell experiments, expressed a p53ΔPGFP protein at much lower levels than p53WT (Figure 5B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: adcy9 (aka adenylate cyclase type 9)
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'p53ΔPGFP-expressing MEFs were viable, recovered with an efficiency of ∼40%, and, as expected from ES cell experiments, expressed a p53ΔPGFP protein at much lower levels than p53WT (Figure 5B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: pacap (aka pituitary adenylate cyclase-activating polypeptide)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-motb (aka motility protein b (escherichia coli k-12))
G: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'p53ΔPGFP-expressing MEFs were viable, recovered with an efficiency of ∼40%, and, as expected from ES cell experiments, expressed a p53ΔPGFP protein at much lower levels than p53WT (Figure 5B).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'Unlike WT MEFs, p53ΔP/ΔP MEFs are unable to arrest cycling after irradiation (5).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: adenylyl cyclase 9 (aka adenylate cyclase type 9)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Likewise, we found that irradiation doses that arrested p53RMCE/− MEFs (which express a wild-type p53 from the RMCE-ready locus, see Figure 2) did not arrest p53ΔPGFP/− MEFs (Figure 5C).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: adenylyl cyclase 9 (aka adenylate cyclase type 9)
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: ec-motb (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Likewise, we found that irradiation doses that arrested p53RMCE/− MEFs (which express a wild-type p53 from the RMCE-ready locus, see Figure 2) did not arrest p53ΔPGFP/− MEFs (Figure 5C).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: adcy9 (aka adenylate cyclase type 9)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Likewise, we found that irradiation doses that arrested p53RMCE/− MEFs (which express a wild-type p53 from the RMCE-ready locus, see Figure 2) did not arrest p53ΔPGFP/− MEFs (Figure 5C).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: kiaa0520 (aka adenylate cyclase type 9)
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'The results confirm that deleting the proline rich domain leads to less active p53 with impaired cell cycle control, and also indicate that a GFP C-terminal fusion can dramatically alter p53 regulation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: adcy9 (aka adenylate cyclase type 9)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'The results confirm that deleting the proline rich domain leads to less active p53 with impaired cell cycle control, and also indicate that a GFP C-terminal fusion can dramatically alter p53 regulation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-motb (aka motility protein b (escherichia coli k-12))
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'In addition, RMCE-ASAP could be used to generate fibroblastic cell lines tailored for the repeated targeting of widely studied genes (p53, c-myc, NF-KB, etc.).
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: kiaa0520 (aka adenylate cyclase type 9)
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'In addition, RMCE-ASAP could be used to generate fibroblastic cell lines tailored for the repeated targeting of widely studied genes (p53, c-myc, NF-KB, etc.).
', select the correct biomedical concept corresponding to 'c-myc'. Answer using one of the provided options. | <Options>: A: basic leucine zipper and w2 domain-containing protein 1 (bzw1 (aka basic leucine zipper and w2 domain-containing protein 1))
B: zslc16a13 (aka uncharacterized protein, loc793210 translation product (zebrafish))
C: rbl1/iso:1/phosres+ (aka retinoblastoma-like protein 1 isoform 1 phosphorylated form)
D: uncharacterized protein, nampta translation product (zebrafish) (znampt) (aka uncharacterized protein, nampta translation product (zebrafish))
E: uncharacterized protein, prkab2 translation product (zebrafish) (zprkab2) (aka uncharacterized protein, prkab2 translation product (zebrafish))
F: lymphocyte antigen 86 (human) (hly86) (aka lymphocyte antigen 86 (human))
G: hpop4 (aka ribonuclease p protein subunit p29 (human))
H: zabcd2 (aka uncharacterized protein, abcd2 translation product (zebrafish))
I: uncharacterized protein, loc101886806 translation product (zebrafish) (zmad2l1bp) (aka uncharacterized protein, loc101886806 translation product (zebrafish))
J: retinoblastoma-like protein 2 isoform 1 phosphorylated form (rbl2/iso:1/phosres+) (aka retinoblastoma-like protein 2 isoform 1 phosphorylated form)
K: None of the above. | K |
<Instruct>: Given the context 'Figure 2
Generating ES cells with a p53 RMCE-ready locus.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'The p53 gene is contained in a 17 kb-long EcoRI (RI) fragment (black boxes: coding sequences, white boxes: UTRs).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: kiaa0520 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'The Flox targeting construct (below), the sequence which was verified before use (Materials and Methods), contains (i) a 3.4 kb-long 5′ homology region; (ii) 0.2 kb upstream of coding sequences, an EcoRI site and L3, a mutant loxP [loxP257, (14)]; (iii) p53 exons; (iv) 0.4 kb downstream, a puroΔTK fusion gene (puDTK) for positive/negative selection (21) and an inverted WT loxP (1L); (v) a 1.2 kb-long 3′ homology region and (vi) the diphteria α-toxin (DTA) gene for targeting enrichment.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: kiaa0520 (aka adenylate cyclase type 9)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context '(A) RMCE with a p53GFP plasmid.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
B: kiaa0520 (aka adenylate cyclase type 9)
C: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'The exchange plasmid, the sequence which was verified before use, contains p53GFP coding sequences flanked by L3 and 1L sites.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcy9 (aka adenylate cyclase type 9)
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Recombinant clones were analyzed by western blot with an antibody to p53.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: actp10 (aka adenylate cyclase type 9)
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
H: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
I: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'In the representative western (right), cells from two independent p53+/GFP ES clones were left untreated or treated with adriamycin (ADR) at 0.5 μg/ml for 24 h, and protein extracts were prepared.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
B: pacap (aka pituitary adenylate cyclase-activating polypeptide)
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: kiaa0520 (aka adenylate cyclase type 9)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ec-motb (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'p53GFP migrated at the expected size of 80 kDa and was expressed at unexpectedly high levels regardless of stress.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap (aka pituitary adenylate cyclase-activating polypeptide)
B: kiaa0520 (aka adenylate cyclase type 9)
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context '(B) RMCE with a p53ΔPGFP plasmid.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
F: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: adenylyl cyclase 9 (aka adenylate cyclase type 9)
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'The p53ΔPGFP exchange construct (which sequence was verified before use) differed from the p53GFP construct only in that it contains a mutated exon 4 (4*) encoding a PRD deletion.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: adenylyl cyclase 9 (aka adenylate cyclase type 9)
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'The p53ΔPGFP exchange construct (which sequence was verified before use) differed from the p53GFP construct only in that it contains a mutated exon 4 (4*) encoding a PRD deletion.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: pacap (aka pituitary adenylate cyclase-activating polypeptide)
E: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'As expected, all except clone x expressed p53ΔPGFP.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: kiaa0520 (aka adenylate cyclase type 9)
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'p53ΔPGFP migrated at the expected size of 75 kDa and accumulated after stress, but at lower levels than p53WT.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: adenylyl cyclase 9 (aka adenylate cyclase type 9)
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'p53ΔPGFP migrated at the expected size of 75 kDa and accumulated after stress, but at lower levels than p53WT.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcy9 (aka adenylate cyclase type 9)
B: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
C: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
D: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
H: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
I: ec-motb (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context '(C) Germline transmission of the p53ΔPGFP mutation.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: adcy9 (aka adenylate cyclase type 9)
D: pacap (aka pituitary adenylate cyclase-activating polypeptide)
E: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'DNA of seven littermates (U42–U48), obtained from mating a p53ΔPGFP chimera with a WT mouse, was analyzed by PCR with primers d and e (see B), with DNA from WT, p53+/ΔP and p53ΔP/ΔP MEFs (5) as controls.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: adenylyl cyclase 9 (aka adenylate cyclase type 9)
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context 'DNA of seven littermates (U42–U48), obtained from mating a p53ΔPGFP chimera with a WT mouse, was analyzed by PCR with primers d and e (see B), with DNA from WT, p53+/ΔP and p53ΔP/ΔP MEFs (5) as controls.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: actp10 (aka adenylate cyclase type 9)
C: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'DNA of seven littermates (U42–U48), obtained from mating a p53ΔPGFP chimera with a WT mouse, was analyzed by PCR with primers d and e (see B), with DNA from WT, p53+/ΔP and p53ΔP/ΔP MEFs (5) as controls.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: kiaa0520 (aka adenylate cyclase type 9)
C: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'U45, a p53+/ΔPGFP mouse, demonstrated transmission of the mutation.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: actp10 (aka adenylate cyclase type 9)
B: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: ec-motb (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Figure 4
Germline transmission of the p53 RMCE-ready locus.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: actp10 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'p53RMCE/+ ES cells were injected into blastocysts to generate chimeric mice.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
G: actp10 (aka adenylate cyclase type 9)
H: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Chimeras (>80%) were then mated with p53+/− mice (Taconic) and MEFs were prepared.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-motb (aka motility protein b (escherichia coli k-12))
H: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
I: adcy9 (aka adenylate cyclase type 9)
J: None of the above. | J |
<Instruct>: Given the context 'This revealed germline transmission of the p53 RMCE-ready locus in MEFs 1, 2 and 6.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
C: adenylyl cyclase 9 (aka adenylate cyclase type 9)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
G: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'Each of these three MEF clones was further analyzed (bottom) with primers f and g (left lanes) and h and i (right lanes), routinely used to genotype p53+/− mice (sequences in Materials and Methods).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-motb (aka motility protein b (escherichia coli k-12))
B: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
C: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
G: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: adcy9 (aka adenylate cyclase type 9)
I: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'MEF 1 are p53RMCE/+ and MEFs 2 and 6 are p53RMCE/− cells.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
B: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-motb (aka motility protein b (escherichia coli k-12))
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pacap (aka pituitary adenylate cyclase-activating polypeptide)
G: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
H: actp10 (aka adenylate cyclase type 9)
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'MEF 1 are p53RMCE/+ and MEFs 2 and 6 are p53RMCE/− cells.
', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
B: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
G: kiaa0520 (aka adenylate cyclase type 9)
H: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
I: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context '(A) RMCE with the p53GFP plasmid leads to the transient observation of cells with intense nuclear fluorescence.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
B: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: adcy9 (aka adenylate cyclase type 9)
D: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
E: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
F: pacap (aka pituitary adenylate cyclase-activating polypeptide)
G: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ec-motb (aka motility protein b (escherichia coli k-12))
I: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context 'p53RMCE/− MEFs, electroporated with a Cre expression plasmid and the p53GFP exchange plasmid, were analyzed 48 h later by fluorescence microscopy.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: actp10 (aka adenylate cyclase type 9)
I: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
J: None of the above. | J |
<Instruct>: Given the context 'p53RMCE/− MEFs, electroporated with a Cre expression plasmid and the p53GFP exchange plasmid, were analyzed 48 h later by fluorescence microscopy.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: kiaa0520 (aka adenylate cyclase type 9)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
D: ec-motb (aka motility protein b (escherichia coli k-12))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
H: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
I: pacap (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
<Instruct>: Given the context '(B) RMCE with the p53ΔPGFP plasmid. p53RMCE/− MEFs, electroporated with a Cre expression plasmid and the p53ΔPGFP plasmid, were selected with ganciclovir.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adcy9 (aka adenylate cyclase type 9)
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
D: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
E: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
H: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context '(B) RMCE with the p53ΔPGFP plasmid. p53RMCE/− MEFs, electroporated with a Cre expression plasmid and the p53ΔPGFP plasmid, were selected with ganciclovir.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: adenylyl cyclase 9 (aka adenylate cyclase type 9)
B: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
C: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
D: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
E: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
H: kiaa1991 (aka e3 ubiquitin-protein ligase rnf169 (mouse))
I: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
J: None of the above. | J |
<Instruct>: Given the context '(B) RMCE with the p53ΔPGFP plasmid. p53RMCE/− MEFs, electroporated with a Cre expression plasmid and the p53ΔPGFP plasmid, were selected with ganciclovir.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
B: pacap (aka pituitary adenylate cyclase-activating polypeptide)
C: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
D: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
E: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
F: pituitary adenylate cyclase-activating polypeptide type i receptor (pacap type i receptor) (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
G: adcy9 (aka adenylate cyclase type 9)
H: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
I: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
J: None of the above. | J |
<Instruct>: Given the context 'PCR with primers b and c next verified that the detected PRD deletions resulted from RMCE at the p53 locus, not random integration (middle row, as expected clones R, S, T and W are positive, but not Q).', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: hcol4a6/sigpep- (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
C: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
D: molybdopterin adenylyltransferase (escherichia coli k-12) (ec-mog) (aka molybdopterin adenylyltransferase (escherichia coli k-12))
E: pacap type i receptor (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: adenylyl cyclase 9 (aka adenylate cyclase type 9)
H: pituitary adenylate cyclase-activating polypeptide (adcyap1) (aka pituitary adenylate cyclase-activating polypeptide)
I: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
J: None of the above. | J |
<Instruct>: Given the context 'Western analysis of positive clones (bottom row) showed that p53ΔPGFP accumulated after ADR, but at lower levels than p53WT.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: uniprotkb:q14031, 23-1691 (aka collagen alpha-6(iv) chain, signal peptide removed form (human))
B: ec-modb (aka molybdenum transport system permease protein modb (escherichia coli k-12))
C: ec-mog (aka molybdopterin adenylyltransferase (escherichia coli k-12))
D: motility protein b (escherichia coli k-12) (ec-motb) (aka motility protein b (escherichia coli k-12))
E: ring-type e3 ubiquitin transferase rnf169 (mouse) (aka e3 ubiquitin-protein ligase rnf169 (mouse))
F: mannitol operon repressor (escherichia coli k-12) (ec-mtlr) (aka mannitol operon repressor (escherichia coli k-12))
G: pacap-r-1 (aka pituitary adenylate cyclase-activating polypeptide type i receptor)
H: adcy9 (aka adenylate cyclase type 9)
I: adcyap1 (aka pituitary adenylate cyclase-activating polypeptide)
J: None of the above. | J |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.