instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept corresponding to 'cxcr-2'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: None of the above. | C |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | D |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept corresponding to '2p domain mechano-sensitive k+ channel'. Answer using one of the provided options. | <Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: kcnc2 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 2)
C: potassium two pore domain channel subfamily k member 10 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: potassium two pore domain channel subfamily k member 4 (homo sapiens) (aka potassium two pore domain channel subfamily k member 4)
E: potassium two pore domain channel subfamily k member 2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | C |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: None of the above. | E |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept corresponding to 'trek1'. Answer using one of the provided options. | <Options>: A: task-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
E: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: None of the above. | E |
<Instruct>: Given the context 'TREK2 is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | C |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | B |
<Instruct>: Given the context 'In transfected cells, TREK2 produces rapidly activating and non-inactivating outward rectifier K(+) currents.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | C |
<Instruct>: Given the context 'TREK2 is blocked by application of intracellular cAMP.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: None of the above. | E |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek1'. Answer using one of the provided options. | <Options>: A: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
B: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
D: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
F: None of the above. | D |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: None of the above. | B |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
E: None of the above. | E |
<Instruct>: Given the context 'TREK2 can be positively or negatively regulated by a variety of neurotransmitter receptors.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | C |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to '5ht4sr'. Answer using one of the provided options. | <Options>: A: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
B: 5-ht4r (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
C: 5-hydroxytryptamine receptor 4 (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
D: somatostatin receptor 4 (homo sapiens) (aka somatostatin receptor 4)
E: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
F: None of the above. | C |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'mglur1'. Answer using one of the provided options. | <Options>: A: mglur5 (homo sapiens) (aka glutamate metabotropic receptor 5)
B: metabotropic glutamate receptor 1 (xenopus tropicalis) (aka metabotropic glutamate receptor 1)
C: glutamate receptor, metabotropic 1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
D: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
E: glutamate metabotropic receptor 1 (homo sapiens) (aka glutamate metabotropic receptor 1)
F: None of the above. | E |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'mglur2'. Answer using one of the provided options. | <Options>: A: gpr2 (homo sapiens) (aka c-c motif chemokine receptor 10)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: glutamate metabotropic receptor 2 (homo sapiens) (aka glutamate metabotropic receptor 2)
D: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
E: glur-2 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 2)
F: None of the above. | C |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
E: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | A |
<Instruct>: Given the context 'These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action.', select the correct biomedical concept corresponding to 'trek2'. Answer using one of the provided options. | <Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | B |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
F: None of the above. | B |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept corresponding to 'interleukin-6'. Answer using one of the provided options. | <Options>: A: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: None of the above. | C |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'related adhesion focal tyrosine kinase'. Answer using one of the provided options. | <Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
C: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
D: frk (drosophila melanogaster) (aka franklin)
E: fak2 (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | E |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
B: frk (drosophila melanogaster) (aka franklin)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
E: frnk (homo sapiens) (aka protein tyrosine kinase 2)
F: None of the above. | C |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: frk (bos taurus) (aka fyn related src family tyrosine kinase)
C: frnk (homo sapiens) (aka protein tyrosine kinase 2)
D: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
E: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
F: None of the above. | F |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'pyk2'. Answer using one of the provided options. | <Options>: A: tyk2 (homo sapiens) (aka tyrosine kinase 2)
B: pyk (homo sapiens) (aka phosphorylase kinase regulatory subunit alpha 2)
C: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
D: pyk2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
E: pyk2 (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | E |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'interleukin-6'. Answer using one of the provided options. | <Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
C: il-6 (homo sapiens) (aka interleukin 6)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | C |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: il-6 (homo sapiens) (aka interleukin 6)
E: None of the above. | D |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
B: frnk (homo sapiens) (aka protein tyrosine kinase 2)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
E: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
F: None of the above. | C |
<Instruct>: Given the context 'However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: il-6 (homo sapiens) (aka interleukin 6)
C: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: None of the above. | B |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
F: None of the above. | D |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | A |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
F: None of the above. | A |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: frk (drosophila melanogaster) (aka franklin)
D: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
E: frnk (homo sapiens) (aka protein tyrosine kinase 2)
F: None of the above. | B |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
E: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
F: None of the above. | C |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
E: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
F: None of the above. | F |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
B: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
E: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
F: None of the above. | C |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
B: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
C: frk (drosophila melanogaster) (aka franklin)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
F: None of the above. | D |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
F: None of the above. | A |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'raftk'. Answer using one of the provided options. | <Options>: A: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: frk (drosophila melanogaster) (aka franklin)
C: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
D: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
E: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
F: None of the above. | A |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
E: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
F: None of the above. | E |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: None of the above. | B |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: None of the above. | A |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
E: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
F: None of the above. | E |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'il-6'. Answer using one of the provided options. | <Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
C: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: None of the above. | C |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
F: None of the above. | A |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept corresponding to 'shp2'. Answer using one of the provided options. | <Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: None of the above. | F |
<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept corresponding to 'alpha(2a) adrenoceptor'. Answer using one of the provided options. | <Options>: A: adra2a (homo sapiens) (aka adrenoceptor alpha 2a)
B: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
C: adrenoceptor alpha 2b (homo sapiens) (aka adrenoceptor alpha 2b)
D: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
E: None of the above. | A |
<Instruct>: Given the context 'Cells were transfected with a bicistronic plasmid containing the alpha2C10 and neomycin phosphotransferase genes.', select the correct biomedical concept corresponding to 'alpha2c10'. Answer using one of the provided options. | <Options>: A: pcdh-alpha10 (homo sapiens) (aka protocadherin alpha 10)
B: integrin subunit alpha 10 (homo sapiens) (aka integrin subunit alpha 10)
C: cyclic nucleotide gated channel subunit alpha 2 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 2)
D: adrenoceptor alpha 2c (homo sapiens) (aka adrenoceptor alpha 2c)
E: alpha2aar (homo sapiens) (aka adrenoceptor alpha 2a)
F: None of the above. | E |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'extracellular regulated protein kinase 1'. Answer using one of the provided options. | <Options>: A: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
B: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
C: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
D: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
E: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
F: None of the above. | C |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'erk1'. Answer using one of the provided options. | <Options>: A: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
B: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
C: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
D: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
E: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
F: None of the above. | A |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept corresponding to 'erk2'. Answer using one of the provided options. | <Options>: A: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
B: mapkk2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
C: sapk2 (homo sapiens) (aka mitogen-activated protein kinase 11)
D: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
E: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
F: None of the above. | D |
<Instruct>: Given the context 'It was unaffected by protein kinase C downregulation but correlated with a transient increase in Shc tyrosine phosphorylation.', select the correct biomedical concept corresponding to 'shc'. Answer using one of the provided options. | <Options>: A: shca (homo sapiens) (aka shc adaptor protein 1)
B: shc2 (homo sapiens) (aka shc adaptor protein 2)
C: shcc (homo sapiens) (aka shc adaptor protein 3)
D: None of the above. | A |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 4 (bos taurus) (aka interleukin 4)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
E: il-4 (homo sapiens) (aka interleukin 4)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
E: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ifn-induced protein of 10 kda'. Answer using one of the provided options. | <Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifitm10 (homo sapiens) (aka interferon induced transmembrane protein 10)
C: ifi30 (homo sapiens) (aka ifi30 lysosomal thiol reductase)
D: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
E: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: il-10c (homo sapiens) (aka interleukin 19)
E: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: il-10c (homo sapiens) (aka interleukin 19)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
E: interleukin 10 (homo sapiens) (aka interleukin 10)
F: None of the above. | F |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'monokine induced by ifn-gamma'. Answer using one of the provided options. | <Options>: A: ld78gamma (homo sapiens) (aka c-c motif chemokine ligand 3 pseudogene 1)
B: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
C: midkine (homo sapiens) (aka midkine)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
B: mig9 (homo sapiens) (aka s100 calcium binding protein p)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
E: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
F: None of the above. | C |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'ifn-inducible t-cell alpha-chemoattractant'. Answer using one of the provided options. | <Options>: A: ifn-alphac (homo sapiens) (aka interferon alpha 10)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
D: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
E: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
F: None of the above. | B |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
B: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept corresponding to 'cxcr3 receptor'. Answer using one of the provided options. | <Options>: A: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
B: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: atypical chemokine receptor 3 (xenopus tropicalis) (aka atypical chemokine receptor 3)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
E: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: interleukin 4 (homo sapiens) (aka interleukin 4)
E: interleukin 4 (bos taurus) (aka interleukin 4)
F: None of the above. | D |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-10'. Answer using one of the provided options. | <Options>: A: il-10 (oryctolagus cuniculus) (aka interleukin 10)
B: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
C: il-10c (homo sapiens) (aka interleukin 19)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: interleukin 10 (homo sapiens) (aka interleukin 10)
F: None of the above. | E |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'il-17'. Answer using one of the provided options. | <Options>: A: interleukin 17c (homo sapiens) (aka interleukin 17c)
B: il-17 (bos taurus) (aka interleukin 17a)
C: il-17 (homo sapiens) (aka interleukin 17a)
D: interleukin 17f (homo sapiens) (aka interleukin 17f)
E: None of the above. | C |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: il-10a (homo sapiens) (aka interleukin 10)
D: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
F: None of the above. | A |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig9 (homo sapiens) (aka s100 calcium binding protein p)
B: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
C: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
D: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
E: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
B: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
E: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
F: None of the above. | F |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
E: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
F: None of the above. | B |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: il4 (bos taurus) (aka interleukin 4)
E: il-4 (homo sapiens) (aka interleukin 4)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-10'. Answer using one of the provided options. | <Options>: A: il-10a (homo sapiens) (aka interleukin 10)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: il-10 (oryctolagus cuniculus) (aka interleukin 10)
D: interleukin 10 (bos taurus) (aka interleukin 10)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'il-17'. Answer using one of the provided options. | <Options>: A: il-17f (homo sapiens) (aka interleukin 17f)
B: il17 (homo sapiens) (aka interleukin 17a)
C: il-17 (bos taurus) (aka interleukin 17a)
D: il-17c (homo sapiens) (aka interleukin 17c)
E: None of the above. | B |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: interferon gamma (sus scrofa) (aka interferon gamma)
E: interferon gamma (homo sapiens) (aka interferon gamma)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'tnf-alpha'. Answer using one of the provided options. | <Options>: A: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
B: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
E: ifn-alpha (homo sapiens) (aka interferon alpha 1)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: il-10c (homo sapiens) (aka interleukin 19)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: None of the above. | A |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
F: None of the above. | D |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: ik cytokine (homo sapiens) (aka ik cytokine)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
E: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
F: None of the above. | F |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: il-10c (homo sapiens) (aka interleukin 19)
E: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | E |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
E: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | E |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
F: None of the above. | D |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
E: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
F: None of the above. | A |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (sus scrofa) (aka interferon gamma)
B: interferon gamma (mus musculus) (aka interferon gamma)
C: ifn-gamma (gallus gallus) (aka interferon)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
F: None of the above. | D |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: il4 (homo sapiens) (aka interleukin 4)
D: il-4 (bos taurus) (aka interleukin 4)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: None of the above. | C |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: None of the above. | D |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
B: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | B |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
C: interferon gamma (xenopus tropicalis) (aka interferon gamma)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: ifn-gamma (gallus gallus) (aka interferon)
F: None of the above. | D |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
E: interleukin 4 (homo sapiens) (aka interleukin 4)
F: None of the above. | E |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: il4 (bos taurus) (aka interleukin 4)
F: None of the above. | F |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (xenopus tropicalis) (aka interferon gamma)
B: interferon gamma (sus scrofa) (aka interferon gamma)
C: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
F: None of the above. | D |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'il-4'. Answer using one of the provided options. | <Options>: A: il-4 (homo sapiens) (aka interleukin 4)
B: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
C: il4 (bos taurus) (aka interleukin 4)
D: interleukin 5 (homo sapiens) (aka interleukin 5)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: None of the above. | A |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'ifn-gamma'. Answer using one of the provided options. | <Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: interferon gamma (xenopus tropicalis) (aka interferon gamma)
E: interferon gamma (gallus gallus) (aka interferon gamma)
F: None of the above. | B |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'tnf-alpha'. Answer using one of the provided options. | <Options>: A: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tnfc (homo sapiens) (aka lymphotoxin beta)
F: None of the above. | B |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'ip-10'. Answer using one of the provided options. | <Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: il-10c (homo sapiens) (aka interleukin 19)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
E: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: None of the above. | E |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'mig'. Answer using one of the provided options. | <Options>: A: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
B: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
C: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
D: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
E: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
F: None of the above. | E |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'i-tac'. Answer using one of the provided options. | <Options>: A: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
D: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
E: ik cytokine (homo sapiens) (aka ik cytokine)
F: None of the above. | B |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical concept corresponding to 'cxcr3'. Answer using one of the provided options. | <Options>: A: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: None of the above. | C |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'graf'. Answer using one of the provided options. | <Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
E: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
F: None of the above. | E |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
B: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
E: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
F: None of the above. | A |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
C: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
D: mllt7 (homo sapiens) (aka forkhead box o4)
E: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
F: None of the above. | F |
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