Collaborative Research: ATD: a-DMIT: a novel Distributed, MultI-channel, Topology-aware online monitoring framework of massive spatiotemporal data

Given current technological, societal and environmental changes, we face ever more diverse potentially destructive threats. Technology has enabled the collection of massive spatiotemporal datasets, which can be used for real-time identification of potential threats. The complexities of such data create exciting challenges for online threat detection, involving the learning and integration of complex nonlinear embeddings for efficient monitoring, the fusion of multiple spatiotemporal data sources for improving detection performance, and scalability for real-time implementation on distributed computing systems. This project will develop a novel Distributed, MultI-source, Topology-aware (a-DMIT) online threat detection framework that tackles these challenges for massive, high-dimensional spatiotemporal data. In developing reliable, scalable and versatile threat detection methods (supported by theory and algorithms), a-DMIT has the potential to improve national health and defense in a broad range of areas, including environmental monitoring, crime monitoring and mobile health. The a-DMIT project will contribute to education by involving undergraduate and graduate students in the research, and developed software will be made publicly available.

a-DMIT will develop three new detection methods that jointly tackle fundamental challenges in online monitoring of massive data streams. The first method, called PERsistence diagram-based ChangE-PoinT detection (PERCEPT), is a novel non-parametric, topology-aware algorithm that extends state-of-the-art tools in topological data analysis for efficient monitoring of high-dimensional data streams. The second, called MUlti-source Monitoring via Gaussian Processes (MUM-GP), is an efficient online Bayesian non-parametric detection method for multi-source spatiotemporal data. The third, called Conditional Auto-Regressive Distributed (CARD) detection, is an online spatiotemporal network monitoring procedure that leverages neighboring spatial information in a distributed and decentralized fashion. a-DMIT will be usable for a wide range of modern threat detection applications, including environmental monitoring, crime monitoring, satellite image monitoring and power grid security.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.


Determination of the Physical and Mechanical Properties of  Fluid-Saturated Porous Rocks Using the Pressure Pulse       Technique


New Methods for the Synthesis of Alkaloids


Mittelassyrische Urkunden aus dem Archiv Assur 14446 (Hervé Reculeau/Barbara Feller)

Mit dem Band von Herve Reculeau und Barbara Feiler, Mittelassyrische Urkunden aus dem Archiv Assur 14446 wird ein weiterer Bestand mittel assyrischer Urkunden aus Assur zugänglich gemacht. Die hierin enthaltenen Texte gehören zu den frühesten mittelassyrischen Urkunden aus der Stadt Assur und auch aus dem übrigen assyrischen Raum. Es handelt sich weitgehend um private Rechtsurkunden. Sie sind Teil eines umfangreichen Fundbestandes, der von Familien aus vier aufeinander folgenden Generationen stammt. Die auf den Urkunden angebrachten Abrollungen von Siegeln dokumentieren die älteste Phase mittelassyrischer Glyptik. Von Bedeutung ist es, dass zahlreiche der abgerollten Siegel zur Mittani-Kerkuk-Glyptik gehören. Durch die gegenwärtig mögliche chronologische Zuordnung der Urkunden werden für die frühe mitte!assyrische Glyptik aus Assur zeitliche Parameter gesetzt.


Improving Vocabulary Learning through Working Memory Training: Examination of Causal Effects and Learning Trajectories

One of the biggest challenges in education is promoting oral language development. In particular, vocabulary learning is key for the development of higher-order oral language and literacy skills. New insights from theory and evidence-based approaches will help children build this foundational skill which in turn will ensure success in school. To this end, researchers will examine the extent to which vocabulary learning is influenced by a cognitive factor (i.e., working memory) and an environmental factor (i.e., input frequency and quality). The two primary goals are to develop and examine the feasibility of implementing working memory training for young children, and to develop working memory training on vocabulary learning, with the potential of mitigating effects of impoverished input often associated with children from low socio-economic (SES) backgrounds.

This project focuses on the causal role of cognition (i.e., working memory) in vocabulary learning for young children. In the first year, the researchers will develop several child-friendly and engaging working memory training modules to examine whether working memory training improves vocabulary learning in general, as well as working memory for children from low SES backgrounds. In the second year, the training modules will be implemented in a small-scale pilot trial where children are randomly assigned to four conditions: (1) working memory training; (2) vocabulary training; (3) combined training on working memory and vocabulary; and (4) business-as-usual control.  The findings are expected to provide proof-of-concept for development of a causal model of working memory in vocabulary learning,  which can inform the development and design of interventions to improve vocabulary learning.


Studying human dendritic cells and DC-SIGN in HIV transmission in vivo using an improved humanized mouse model

PROJECT NARRATIVE This exploratory study will produce an optimized animal model to study HIV transmission in vivo. Using this mode, we will investigate the role of dendritic cell and its cell surface receptor in HIV transmission. This study will reveal cellular and molecular mechanisms that link HIV transmission to microbial stimuli.


Aboriginal/feminist solidarity around violence against women:  challenges and possibilities

Social Sciences and Humanities Research Council of Canada


放射線核医学領域における多種モダリティーの3次元画像間の位置合わせ手法の確立

Principal Investigator：笹山 哲, Project Period (FY)：1992, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Radiation science

Japan Society for the Promotion of Science


Discovery and characterization of ocular regulatory elements through evolutionary analysis

Project Narrative This research project promises to deliver a number of insights into the evolution of gene expression in the eye and congenital eye disease. By contrasting the genomes of blind and sighted mammal species, it will pinpoint regions of DNA important for vision and which are likely to be involved in human eye diseases. The project will then explicitly test for mutations in these regions in patients with congenital eye disease.


FUNCTIONAL GENOMICS AND MECHANISM OF BCL11B ACTION IN LYMPHOCYTE COMMITMENT

PROJECT NARRATIVE Human genetic studies suggest that much of the genetic susceptibility to disease is related to the machinery that controls gene expression, more than defects in the genes themselves. Current experimental techniques enable researchers to catch glimpses of actual gene regulators at work all across the genome, an important step toward being able to diagnose and eventually correct gene regulation problems, but much remains to be learned about how to control the regulators' effects. For example, Bcl11b is a vital regulator of gene expression for the immune system, which has to work properly to avoid leukemia, yet it controls different genes in different kinds of immune cells even though they have identical DNA. This proposal identifies the additional gene regulation mechanisms that explain how Bcl11b works different ways in different immune cells.


植物生長物質コチレニン類による新たなヒト骨髄性白血病治療薬の創製基礎研究

コチレニンAによる新たなヒト骨髄性白血病細胞分化誘導活性に注目し、その入手可能な構造類似化合物のフシコクシン(FC)についても構造と活性の両面から検討を行い、がん細胞分化誘導活性について重要な部分構造の特定を試みる。これらの動物実験系における有効性についても検討を加え、コチレニンAに優る強力なヒトがん細胞制御作用物質の創製を目指す。1)ヒト白血病細胞分化誘導活性におけるコチレニンとフシコクシンの構造・活性相関の検討これまでに調製した各種誘導体について、ヒト骨髄性白血病細胞分化誘導活性を評価した。(1)コチレニンAから誘導した糖鎖エポキシドの各種化学変換物では、何れもコチレニンAより細胞分化誘導活性が低下した。(2)コチレニンと同じ3α-ヒドロキシ基を有するFC-Jと3'-デアセチル-FC-Aの各化合物(3α-OH-FC-J, FC-R)においては、分化誘導活性は認められなかった。(3)コチレニンFとIは、それぞれ糖の6'位にエポキシド側鎖とオレフィン側鎖を有するが、分化誘導活性は前者に強く現れた。(4)FC-Jの糖部にエポキシド側鎖を導入した新誘導体(FC-JE,2)を参照)は、分化誘導活性はほとんどなく、細胞毒性が強まった。以上の事から、分化誘導活性に必要な構造は、糖側鎖のエポキシドの存在、およびアグリコン部分の3,12位の両水酸基の欠如と考えられた。現在、FCの12位水酸基の除去とエポキシド糖側鎖の導入について検討を行い、貴重なFC-Jを用いる実験において目的の誘導体が得られる見通しとなっている。2)フシコクシン類の各種誘導体の調製(前年度からの継続研究)Phomopsis amygdali F6株の培養により、貴重なFC-Jを数100mg調製した。得られたFC-Jを塩酸で処理し、そのデイソペンテニル誘導体を調製した。この糖部分にエポキシドを有する側鎖を4',6'間にアセタール型に導入した誘導体を調製した。新たなエポキシ側鎖を有するFC-J誘導体(FC-JE)は4種のジアステレオマー混合物であるが、この細胞分化誘導活性を評価した。結果については前項に記述した。


Genomic analysis of pediatric SIRS and septic shock


PITUITARY ROLE IN ESTROGEN-EVOKED GONADOTROPIN RELEASE

TEXAS TECH UNIVERSITY HEALTH SCIS CENTER


Grundlagen einer konsistenten Charakterisierung und Bemessung von WAAMgefertigten Stahlbauteilen bei hoher Abschmelzleistung

Mit der Wire Arc Additive Manufacturing (WAAM) eröffnen sich dem Stahlbau außerordentlich große Perspektiven neuer Gestaltungs- und Einsatzmöglichkeiten. Jedoch sind sowohl die Technologie in Hinblick auf eine im Stahlbau erforderliche Fertigungsgeschwindigkeit als auch die stahlbaumäßige Bemessung unter Berücksichtigung der prozess-und bauteilbedingten Unregelmäßigkeiten von Geometrie und Struktur noch in weiten Teilen unerforscht. Dabei sind die Fertigungstechnologie und die der Bemessung zugrundeliegenden Charakteristika von mit WAAM hergestellten Bauteilen miteinander eng verbunden. Die Erforschung der für den Stahlbau erforderlichen Grundlagen zur Schaffung erhöhter Abschmelzleistungen und Fertigungssicherheit im Bereich der WAAM, der geometrischen und strukturellen Merkmalscharakterisierung, sowie die Grundlagen einer mit Fertigung und Charakterisierung konsistenten Bemessung von WAAM-gefertigten Stahlbauteilen mit „freier Form“ sind deswegen Gegenstand dieses Projekts. Auf der Fertigungsseite betrifft dies die Erhöhung der Abschmelzleistung unter sicherer Abschätzung von Verzug und Eigenspannungen, die Optimierung des Fertigungsergebnisses in mechanisch-technologischer Hinsicht unter Berücksichtigung der einsetzbaren Drahtwerkstoffe sowie die Weiterentwicklung und Integration der Automatisierungsprozesse. Dies betrifft auch die Parametrierung, Steuerung und Bahnkurvenprogrammierung. Nach der Klärung von prinzipiell machbaren Topologien beziehen sich die Fragestellungen weiter auf das Finden von geeigneten Parameterkonstellationen der Fertigung, um gewünschte Material- und Geometrieeigenschaften sicher zu erreichen, sowie auf die Charakterisierung des gefertigten Bauteils hinsichtlich Material und Geometrie. Neben Festigkeitsverteilungen und dem Einfluss der Eigenspannungen beeinflussen insbesondere die Oberflächenrauheit, sich ergebende Dickenabweichungen und Welligkeiten der Bauteilwandung die für die Bemessung zu verwendenden charakteristischen Werte für Geometrie und Material. Hierfür werden statistische Merkmale abgeleitet. Es wird sodann auf ein Konzept von Fertigungsklassen abgezielt, deren charakteristische Merkmale die Bemessung wieder aufgreift. Hierzu sind die zu erwartenden Bauteilformen und Bemessungsfälle sowie die Fertigung incl. Automatisierung zu berücksichtigen. Fertigung und Bemessung müssen untereinander abgestimmt sein, da die strukturmechanischen Eigenschaften des Bauteils von der fertigungsbedingten Beschaffenheit abhängen. Darauf aufbauend beziehen sich die Fragestellungen der Bemessung auf ein möglichst zweckmäßiges Nachweiskonzept, in dem die diversen Bemessungsfälle eingebettet werden können. Unter Berücksichtigung der aus dem WAAM-Prozess entstammenden Material- und Geometrieabweichungen sollen der Bauteilwiderstand unter Zugspannungen, das Stabilitätsverhalten sowie die Ermüdungsfestigkeit unter besonderer Berücksichtigung des streuenden Charakters der Merkmale des additiv gefertigten Bauteils erforscht werden.


Genetic and Molecular Analyses of Human LINE-1 Retrotransposition

Narrative  The average human genome contains ~100 active Long INterspersed Element-1 (LINE-1 or L1) sequences that can mobilize to new genomic locations by a process known as retrotransposition. L1 retrotransposition events in the germ line, during early development, or in somatic cells generate inter- and intra-individual genetic diversity and are implicated in a myriad of sporadic genetic diseases, including Hemophilia A, Duchenne muscular dystrophy, and certain cancers. The goal of this R01 proposal is to use a cultured cell retrotransposition assay in conjunction with an integrative strategy that involves genetic, molecular biological, biochemical, multi- omic, and computational approaches to: (i) elucidate how L1s move to new genomic locations; and (ii) determine how host factors act to restrict or facilitate L1 retrotransposition. This knowledge will provide insights into how L1 retrotransposition contributes to human disease, human genetic variation, and human genome evolution.


Canada Graduate Scholarships Program - Masters Scholarships


Modelling Uncertainty in Modern Power Systems

Big data solutions; Data mining; Demand-side management; demand-side resources; Electricity markets; Forecasting; Optimization under Uncertainty; Power system planning; Power systems operation; Renewable energy integration

Natural Sciences and Engineering Research Council of Canada


Pathways from genotype and environment to melanoma

QUEENSLAND INSTITUTE OF MEDICAL RESEARCH


Dennis Brooks | University of Florida - Estados Unidos

A Sociedade Latina Americana de Oftalmologia Veterinária e o Colégio Brasileiro de Oftalmologia Veterinária congregam interessados na especialidade. As reuniões tem propiciado a troca de informações e discussão de assuntos emergentes sendo que temas como catarata, ceratites, glaucoma e uveítes serão desenvolvidos. O professor Dennis Brooks proferirá conferências sobre sua área de atuação bem como participará de WetLab em facoemulsificação e atendimento de casos clínicos no Serviço de Oftalmologia da FMVZ USP. (AU)

Fundação de Amparo à Pesquisa do Estado de São Paulo

Auxílio à Pesquisa - Pesquisador Visitante - Internacional

Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ)


Student Elective Prize for Mr Prashen Pillay

Preconceptions of labour pain amongst antenatal women. A transatlantic twin centre comparative study


BRCA1 TESTING IN A LARGE AFRICAN AMERICAN KINDRED


HERPETIC STROMAL KERATITIS PATHOGENESIS: AN ANIMAL MODEL


"Gott ist Richter unter den Göttern" (Ps 82,1b): Mono, Polytheismus, die Ontologie der Teilhabe im Platonismus und Christentum, die Henaden bei Proklos und der interreligiöse Dialog bei Cusanus ApuleiusRezeption in C.S. Lewis' Till We Have Faces Augustins Hermeneutik in De Genesi ad litteram

Das Ziel des Heisenberg-Programms ist es, herausragenden Wissenschaftlerinnen und Wissenschaftlern, die alle Voraussetzungen für die Berufung auf eine Langzeit-Professur erfüllen, zu ermöglichen, sich auf eine wissenschaftliche Leitungsfunktion vorzubereiten und in dieser Zeit weiterführende Forschungsthemen zu bearbeiten. In der Verfolgung dieses Ziels müssen nicht immer projektförmige Vorgehensweisen gewählt und realisiert werden. Aus diesem Grunde wird bei der Antragstellung und auch später bei der Abfassung von Abschlussberichten - anders als bei anderen Förderinstrumenten - keine "Zusammenfassung" von Projektbeschreibungen und Projektergebnissen verlangt. Somit werden solche Informationen auch in GEPRIS nicht zur Verfügung gestellt.


Studies on the creation of new type silk obtained from new cocoons differ sericin content and dilament size from conventional cocoons.

The silk worm races which are different in denier, length of cocoon filament, degumming loss percentage from conventional silk worm races were breeded and the physical properties of the silk worm cocoon filaments obtained from these races were investigated. Further, the various properties of fine structures, mechanical properties, endowed effect of shrinkage, dyeing and chemical treatments were investigated. Results obtained were as follows; the cocoon length of fine size cocoons had 1000 m and the filament size showed value 1.5 d. In the coarse size cocoons, length and size showed value 700 m, 4.50 d respectively. In the cocoons a smaller sericin content, the degumming loss percentage showed value 22%. The raw silks obtained from the cocoons which have a smaller size showed a negative correlation between strength and elongation in the tensile properties and the empty holes of the cross section at the breaking point were prr. contrary to this the raw silks obtained from the cocoons which are a larger size showed a positive correlation in the tensile properties and the empty holes were rich. Among the raw silks obtained from these cocoons, the raw silk obtained from the cocoons containing a smaller sericin content showed low value of Young's modulus, large endowed effect of shrinkage, and the stability of shrinkage. Synthetically, examining these effect, it was found that the cocoons containing a smaller sericin content were favorable for the knitting materials.

Japan Society for the Promotion of Science

Grant-in-Aid for General Scientific Research (B)

Faculty of Technology, Tokyo University of Agriculture and Technology


THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF TTO IN THE AMOUNT OF 430,408 ON CONTRACT HR0011-18-2-0028.


Erforschung der Zusammenhänge zwischen externer Verspannung und Generation tiefer Zentren in Halbleiterstrukturen von DiodenLaserbauelementen

Keine Zusammenfassung vorhanden


生殖の形態変化に関する歴史社会学的研究

今年度の研究活動においては、「新しい生殖技術」研究の前提をなす作業の一環として、妊娠中絶をめぐる倫理的・社会的問題について考察を深めることに主眼をおいた。これは1991年に発表した拙論「女性の自己決定権の擁護」に対して、新たな視点からの反論が加えられたことを受け、その誤解をただし、生殖技術全般に関する議論につきものの陥穽をあらかじめ明らかにしておく目的で行われたことである。具体的には、(1)受精の瞬間=生命権の「主体」たる「人間」の成立、という発生観の恣意性、(2)妊娠中絶に関わる判例における「期間規定」「適応規定」という二分法の不徹底性、(3)生殖倫理に関わる男女の権利の非対称性、(4)技術水準による「倫理」の絶対的被制約性、等を主要な論点とし、旧論を補強した。この論を構築する過程で、胎児を受精の瞬間から生命権の主体として認めるプロ・ライフ的論理の根底的な曖昧さと政治性とがより明らかになった。さらに今後の展開に資する点としては、法学的議論において、女性の自己決定権がしばしばJ・ロック以来の「自己身体の自己所有権」という論理の延長上で語られることの不十分さを浮かび上がらせることができたと言える。すなわち、1960年代以降の新しい女性開放運動が主張し、近年では女性の「生殖に関わる健康と諸権利」という思想に結実してきた内容は、身体の自己所有ではなくむしろそうした発想が前提としてきた心身観を見直し、所有とは異なるあり方として自己/身体の存在を捉え直そうという提言をその核心においているということが明確に認識されたのである。これは今後、胎児のみならず受精卵や生殖細胞の倫理的地位を考えるにあたっても、所有論を超える人権論の構想の原点として、極めて重い意義を持つ論点であろう。


Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Divisione della Cultura Dipartimento dell'istruzione e della cultura del Cantone


Unconditional tabulation of class groups of real quadratic fields

No summary - Aucun sommaire

University Undergraduate Student Research Awards


Archival description as rhetorical genre in traditional and web-based environments

Social Sciences and Humanities Research Council of Canada


Enhancement of a Research-Based Curriculum Through          Microscopy and Imaging

Recent progress toward a research-based curriculum in geology  emphasizes the use of optical microscopy and the interaction of  electromagnetic radiation with matter in the study of geological  problems.   This project enhances these curricular changes with  the implementation of a research-grade petrographic microscope  that includes 35-mm photography and video capabilities.    Improvements resulting from this project include enhanced  demonstration capabilities throughout the course curriculum;  greater comprehension of scientific methods and principles by  non-science-majors and potential science majors in introductory  courses; the exposure of undergraduate majors to modern  petrographic techniques that previously were not possible; and  the enhancement of independent research projects.  The microscope  and video/photographic system makes the study of rocks and  minerals more appealing to non-science-majors and facilitates the  application of rock and mineral studies as a means to  understanding the composition and evolution of the Earth,  environmental problems, and the origin and evolution of life in  introductory courses.   Use of the imaging capabilities to  demonstrate optical techniques to students in Mineralogy enhances  the comprehension of optics theory and techniques resulting in  increased student use of optical methods as investigative tools  later in the course and in other upper-level courses.   The  microscope/imaging system is also being used to involve students  in interactive laboratory projects in courses in mineralogy,  petrology, structural geology, economic geology, sedimentology,  and paleontology.   Finally, the research-grade petrographic  microscope with modern imaging capabilities enhances the quality  of undergraduate research publications, presentations, and  reports resulting from independent projects, honors projects, and  senior capstone projects that are now required for graduation.


CYTOCHEMISTRY OF CENTRAL AUDITORY PATHWAYS

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT


EAGER: Functional Integration of Synthetic Kinases into Endogenous Signaling Networks

Cells can acquire new genes by natural mechanisms (e.g. horizontal gene transfer) or by artificial means (e.g. genetic engineering). We are beginning to understand how newly-acquired genes are integrated into the host's genome, but the evolutionary mechanisms by which the proteins produced by these genes become functionally incorporated into the cell's regulatory networks remain largely unknown. In this project, synthetic biology and directed evolution approaches will be used to recreate and analyze in the laboratory this network rewiring process. Using yeast that have been engineered with signaling modules taken from the mammalian mitogen-activated protein kinase cascade, evolutionary strategies will be applied in the laboratory to reward individual yeast cells that acquire mutations resulting in functional utilization of these introduced mammalian proteins. During this selection process, genome sequencing will be performed to characterize the mutations that occur and to reconstruct the evolutionary processes that result in functional rewiring of the host's signaling networks.

Broader Impacts: The scientific principles underlying this research will be used to train graduate and undergraduate students, including those from underrepresented minorities. Modules on evolution in synthetic biology will be added to an undergraduate course taught by the principal investigator. Undergraduates will also have the opportunity to learn about synthetic biology through the International Genetically Engineered Machine (iGEM) competition. Additional outreach will be targeted to high school teachers and high school students through summer training programs. The insights gained from this project will have relevance for understanding the emergence of antibiotic resistance in microbes, the cultivation and properties of genetically modified crops, and the design of novel synthetic biology devices.


PheBC: bias correction methods for EHR derived phenotype

Project Narrative Data derived from electronic health records (EHR) provide tremendous opportunities for clinical and translational research. A key challenge remains that the reproducibility of findings across studies is limited, which raised a fundamental concern on the value of these researching findings. The overarching goal of this proposal is to develop a rigorous bias correction tool through modern knowledge engineering and data-driven statistical modeling, for enhancing the reproducibility of EHR-based clinical findings.


Paläoumwelt und Klimarekonstruktion in der Winterregenzone Südafrikas mit Hilfe integrierter Untersuchungen lakustriner und mariner Archive

Der globale Klimawandel beeinträchtigt die derzeitige Wasserverfügbarkeit in vielen semi-ariden und ariden Gebieten der Welt, wie beispielsweise im südlichen Afrika. Für präzise Vorhersagen zukünftiger Veränderungen des regionalen Wasserhaushaltes und des regionalen Klimas ist es notwendig sowohl die Steuerungsfaktoren für Umwelt- und Klimaveränderungen der Vergangenheit als auch deren räumliche und zeitliche Variationen zu identifizieren. Das angestrebte Forschungsprojekt wird einen Beitrag zum Verständnis der Holozänen Umwelt- und Klimavariabilität in der Winterregenzone Südafrikas leisten.Innerhalb des beantragten Projektes sollen Paläoumwelt-, Paläoklima-, und Meeresspiegelveränderungen mit Hilfe eines Multi-Proxy Ansatzes hoch-auflösend rekonstruiert werden. Die Basis hierfür bilden geochemische, mineralogische und bio-geochemische Untersuchungen eines bereits geborgenen 13,65 m langen Seesedimentkernes aus dem Küstensee Verlorenvlei, der die letzten 9000 cal BP abdeckt. Vergleichbare Daten aus Untersuchungen eines marinen Sedimentkernes, vom Bereich vor der Küste des Verlorenvleis, werden von Projektpartnern geliefert. Der Vergleich beider Archive soll Veränderungen bestimmter Parameter während des Transportes vom Land zum Ozean aufklären, und dabei helfen, eindeutige Klimasignale abzuleiten. Neben der Untersuchung der natürlichen Klimavariabilität sollen die Untersuchungen der Seesedimente des Weiteren neue Informationen zum menschlichen Einfluss auf die Umwelt erbringen. Aus den übrigen beiden Niederschlagszonen Südafrikas (Übergangs- und Sommerregenzone) werden ebenfalls aus Untersuchungen von lakustrinen und marinen Archiven durch Projektpartner Datensätze geliefert. Diese werden im Rahmen des sogenannten RAIN-Projektes, gefördert durch das Bundesministerium für Bildung und Forschung (BMBF), erhoben, zu dem das hier beantragte Projekt assoziiert werden soll. Dies wird die Rekonstruktion der Dynamik der drei Niederschlagszonen in Südafrika während des Holozäns ermöglichen. Die Identifikation der raum-zeitlichen Veränderungen der Steuerungsfaktoren regionaler Umweltveränderungen wird ebenfalls zum Verständnis der globalen Klimadynamik beitragen können.


Cyclic nucleotide phosphodiesterase regulation in vascular calcification

PROJECT NARRATIVE Calcification that develops in leg arteries of patients with diabetes, chronic kidney disease, and peripheral artery disease is strongly associated with increased cardiovascular morbidity and mortality. This proposal seeks to demonstrate that a specific enzyme, the phosphodiesterase 10A (PDE10A), plays a crucial role in vascular calcification by regulating p38-MAPK-MMP-3 signaling. Our goal is to target PDE10A as a novel therapeutic strategy to reduce medial artery calcification and prevent amputation in our patients.


Mechanism of PAI-1 Polarization to Myoendothelial Junctions

Metabolic syndrome is prevalent in over 50% of the American population, which if left untreated, can lead to severe cardiovascular diseases, such as hypertension and type II diabetes. However, there is currently no known therapeutic treatment. It is known that the protein plasminogen activator inhibitor- 1 (PAI-1) is always prevalent in high concentrations in the circulation as metabolic syndrome progresses and recent work by our laboratory has indicated that PAI-1 can be found in a very specialized location in the walls of blood vessels, the myoendothelial junction. Our grant proposes to dissect the mechanisms whereby PAI-1 is localized to the myoendothelial junction in hopes of understanding how PAI-1 may contribute to, or exacerbate, metabolic syndrome in the vasculature. Successful completion of this proposal could lead to novel therapeutic targets for treatment of metabolic syndrome.


鼻腔内一酸化窒素(NO)の鼻腔通気に対する影響の研究

運動負荷前後の鼻腔通気度と鼻腔産生NOを同時に計測し、その関係を検討した。鼻副鼻腔疾患を有さない健康成人男子を対象とした。運動負荷前後の鼻腔通気度と鼻腔産生NO量を同時に測定し、比較検討した。1.運動負荷30分間の安静により室内環境に適応させた後、トレッドミルを用いて傾斜10°、速度6km、時間4分間の運動負荷を与えた。2.鼻腔通気度の測定前鼻誘導法により測定した。100Paにおける両側の抵抗値(Pa/cm^3/min)およびパーセント表示で表した。3.鼻腔産生NO量の測定小型のポンプを用いて一側の外鼻孔にチューブを装着し、15秒間換気し250mlのガスを収集しNO濃度既知のガス2000mlで希釈してNOアナライザーにより測定した。得られた結果を単位時間あたりのNO産生量として表した(nL/min)。測定の際には被験者の頬を膨らませ、口腔内の圧を上昇させ鼻腔を下気道から遮断された腔として下気道からの呼気ガスに影響されない状態とした。『結果』 いずれの被験者においても運動負荷後、鼻腔通気度は改善し、鼻腔産生NO量は減少した。運動負荷により通気度は0.27±0.04から0.17±0.04に改善し、鼻腔産生NO量は323±91から229±63に減少した。両者は運動負荷前後おいて統計学的に有意な変化を示した。以上より運動負荷後の鼻腔通気度改善時に、測定した鼻腔産生NO量が減少したことは、鼻腔通気度の変化にNOが関与している可能性があると考えられた。


Les suretes reelles en changement : l'analyse de l'actualite et son avenir

At the beginning of 21th century, Japan and France have revised the civil law, what is called the real securitys, les suretes reelles in French. This study intended to analyze the situation of two laws, and to clarify some changes in common and some differences. We can have a perspective on future with our works.

Grant-in-Aid for Scientific Research (C)


心身障害児特に視力障害児・聴力障害児の性行動に関する実態調査とその指導法に関する研究

Principal Investigator：黒川 義和, Project Period (FY)：1977, Research Category：Grant-in-Aid for Encouragement of Young Scientists (B), Research Field：教育学


ドライアッシュ式ジェット噴流層石炭ガス化装置の開発に関する基礎研究

本年度は, ベンチスケールの一塔二段粒子層方式のガス化装置を作成して酸素分割供給法で太平洋炭のガス化実験をおこない, 以下の成果を得た. 1.ジェット噴流層の流動特性を詳細にしらべ(1)噴流部における粒子の上昇速度はガス流速の増加によって顕著に増加するが, 環状部における粒子の下降速度の変化は比較的小さいこと, (2)粒子の質量流束(flux)はガス流速の増加とともに層半径方向へ広がった分布を示し, 層中心付近の上昇粒子の流束は減少すること, (3)粒子の質量循環速度はノズル径や静止時の粒子層高に依存せず, ガス流速に比例して増加すること, (4)層の空間率は噴流部の方がその外側の環状部の値より小さく, 通常型噴流層での結果とは逆の傾向を示すことなどを明らかにした.2.小型固定層装置でガス化速度に及ぼすCO_2とCOの分圧の影響をしらべ, 速度式は吸着項を含むL-H型速度式で精度よく表現できることを認めた.3.太平洋炭のガス化実験では, 従来のドライアッシュ方式のガス化炉で困難とされている1000°C以上の高温でも, 本方式のガス化炉はクリンカートラブルなしに操作が可能であることを確認した. ガス化成績に及ぼす操作条件の影響に関しては, ガス化温度900〜1180°Cの条件で炭素転化率75〜80%, 冷ガス熱効率70〜75%, 水蒸気分解率20〜30%を得, 酸素比がガス化成績に最も大きな影響を及ぼすことを明らかにした. 生成ガスの組成は水素38〜45%, 一酸化炭素25〜29%, 炭酸ガス22〜28%, メタン3%で, その総発熱量は11〔MJ/m^3〕であった.以上の結果より, 本研究で開発したガス化炉ではガス化反応の高温化によって炭素転化率と生成ガス品位の向上が達成できることおよびガス化炉フリーボード部の改良で未反応炭素の飛び出し量の低減をはかれば反応成績をさらに向上させ得るとの結論を得た.

Grant-in-Aid for Scientific Research on Priority Areas


Unshielded quantitative imaging of magnetic nanoparticles


UNDERSTANDING SUPRATHRESHOLD HEARING DEFICITS

PROJECT NARRATIVE  The purpose of this research program is to improve our understanding of suprathreshold hearing deficits and to establish a theoretical framework for the development of diagnostic methods for hidden hearing loss in humans. The work addresses issues that have both basic scientific interest and applied clinical relevance. The work will improve our understanding of potential mechanisms underlying hearing and listening difficulties. The ability to diagnose hidden hearing loss in the clinic will usher in new methods for clinical evaluation and may lead to advances in intervention strategies for individuals who have hidden hearing loss. Therefore, the proposed research is relevant to public health because it applies scientific knowledge to address the effects of hearing loss, which affects more than 30 million people in the US.


Collaborative Research: Wave driven flow through a shallow, fringing reef

Coral reefs face two significant long-term challenges to their existence:  (1) Ocean acidification, which hinders the ability of corals to calcify; and (2) Ocean warming, which leads to coral bleaching.  The Ofu reef (American Samoa), home to corals that seem to have exceptional bleaching resistance, is the location of active research into how corals may be able to meet those challenges biologically and biogeochemically. Given that both carbon system and temperature dynamics on the reef depend on flow, the physical insights and quantitative results from the data and modeling of this study should provide significant input to studies of ecology and biogeochemistry at Ofu and other similar reefs. In addition, the project will advance the technology for mapping reefs at high resolution.  The project will involve several undergraduate and graduate students, as well as a postdoctoral scientist, providing unique material for university courses.  The results of this study will be brought to the general public through a series of short online videos, produced to explain the link between hydrodynamic processes and reef health.

The goals of this project are: (1) Test the concept that the relative importance of friction in the lagoon and friction on the reef crest determines the structure of the overall circulation; (2) Test the hypothesis that drag coefficients related to local, spatially averaged, flows can be estimated from data on reef topography; (3) Carry out a quantitative evaluation of the dynamics of Ofu reef flows using a depth-averaged circulation model based on detailed bathymetry and estimates of spatially variable drag parameterizations.  The primary activities of this project would be: (a) Mapping of reef bathymetry at decimeter scale using an Unmanned Aerial Vehicle carrying cameras and novel image processing of the resulting images; (b) Deploying a set pressure loggers, temperature loggers, acoustic Doppler current profilers and a meteorological station for a 2-km long section of the Ofu reef for two one-month periods and analyzing the results of these observations to estimate flow properties such as drag; (c) Idealized and realistic modeling studies carried out using a three dimensional model. The design of the instrument array in combination with the mapping and modeling is intended to both test the conceptual circulation model and to evaluate how drag on different parts of the reef varies with overall depth, flow and with geometric parameters describing the physical structure of the reef.


Genetic dissection of endoplasmic reticulum stress in POMC neurons

Project Narrative The proposed studies will greatly increase our understanding of the mechanisms underlying leptin and insulin resistance and obesity. The study findings will provide valuble information with which to develop treatment strategies for the prevention of obesity and diabetes.


AL NATIONAL GUARD MASTER COOPERATIVE AGREEMENT AIR NG FIRE PROTECTION ACTIVITIES APPENDIX 1024B

NATIONAL GUARD MILITARY OPERATIONS AND MAINTENANCE (O&M) PROJECTS


Literary portrayals of domestic violence in early modern England


Tomorrow I was always a lion: Investigating psychosis and recovery

Through a creative collaboration between Belarus Free Theatre (BFT), scientific consultants (including Kings College IoPPN and Institute of Neuroscience Trinity College Dublin), and clinical practitioners working with young people, BFT will create a new theatrical and digital production based on the memoir ‘A Road Back from Schizophrenia’ by Norwegian psychologist Arnhild Lauveng. By bringing together contributors from across disciplines into the creative team, the project aims to advance understanding and examine a range of different questions raised by the memoir, including (i) the nature of "recovery" from schizophrenia vs. managing and living with the condition, (ii) The factors that impact vulnerability to psychosis and recovery, (iii) The interplay between genetic factors and environmental conditions in the manifestation of psychosis, (iv) Social and cultural explanations and interpretations of disease and how they affect stigma. Contributions from scientific contributors will be incorporated into the production. Through collaboration with Young Minds (NGO partner) and performance runs in The Albany Theatre (London), Kings/Falmouth University, Contact Theatre (Manchester). BFT will engage diverse audience in dialogue about the nature of mental illness, recovery, and social interpretations. Post-show workshops and discussions will continue to feed into the learnings from the project.


Interplay between the Mtb electron transport chain and carbon metabolism

There is strong interest in developing drug compounds that target and disrupt oxidative phosphorylation (OXPHOS) as a means to kill Mycobacterium tuberculosis (Mtb), the etiological agent of TB disease. Despite the recent development of anti-TB drugs that target the Mtb electron transport chain (ETC), it is currently unknown how inhibition of respiratory complexes in the ETC leads to efficient cell killing. In this proposal, we will test the hypothesis that interplay exits between the Mtb ETC and central carbon catabolism that prevents effective killing by anti-TB drugs.


INVESTIGATION OF ADVANCED COMPOSITE MATERIALS AND AUTOMATED PROCESS

National Aeronautics and Space Administration


ZINC FINGER TRANSCRIPTION FACTORS IN KIDNEY DEVELOPMENT


Vaccine-enhanced respiratory syncytial virus disease


RADIOLOGICAL DIAGNOSTIC ONCOLOGY GROUP 11


Chemical Approaches to Mapping Cell Signaling Pathways

PUBLIC HEALTH RELEVANCE: Kinase and phosphatase enzymes are involved in various diseases and are the target of multiple pharmaceutical drugs. The application outlines new chemical approaches to characterizing kinase and phosphatase substrates to aid in the understanding of disease and development of new treatments.


Development of measuring system for charge distribution

A system for visualizing the electrostatic charge without contact using charged material oscillation method has been developed. There, it was established a technology to convert the information of the charge from an electric field, and a focused ultrasoun

Japan Society for the Promotion of Science

National Institute of Advanced Industrial Science and Technology


Concentracao serica de igc de cabritos recem nascidos alimentados com colostro de cabras submetido ou nao a tratamento termico e com colostro de vacas.

Fundação de Amparo à Pesquisa do Estado de São Paulo

Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV)


Summer Institute for College Teachers in Mathematics


MATERIALS SCIENCE OF ELECTRODES AND INTERFACES FOR HIGH PERFORMANCE ORGANIC PHOTOVOLTAICS

OFFICE OF SCIENCE FINANCIAL ASSISTANCE PROGRAM


無麻酔高血圧ラットの末梢血管抵抗の研究

Principal Investigator：入内島 十郎, Project Period (FY)：1984 – 1985, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：General physiology


対人認知における先行経験の暗黙裡の影響について

Principal Investigator：池上 知子, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Psychology


An Ideological and Historical Study of the Cybernetics Movement

本研究は以下の三つの問いによって構成される。①サイバネティックスとは何であったのか？②サイバネティックス運動の進展の中で「情報的世界観」が如何なる理路で形成されてきたか？③現在の情報社会は「情報的世界観」を、その社会構造にどのような形で思想的に組み込んでいるのか？「サイバネティックス」を、ウィーナー思想のみならず、彼に影響を受けた第二世代によって20世紀いっぱいに渡って展開された諸思潮も含む「サイバネティックス運動」として捉え返し、その生成から「情報的世界観」の形成、様々な分野でのその適用迄を系統的に跡付け、運動の全貌を科学・技術思想史的なパースペクティヴから解明する。


Modulation of fibronectin to improve integration of dental implant materials


Fundação Getúlio Vargas (FGV). Escola de Economia de São Paulo (EESP)


Laser Aided Direct Metal Deposition Deposition of Three-    Dimensional Components With Controlled Dimension,           Microstructure and Mechanical Properties

Rapid prototyping by curing polymers with laser light has created considerable interests in industry to generate three dimensional parts directly from Computer Aided Design (CAD) drawings to aid design processes.  Laser cladding by layers offers the possibility of fabrication of 100% dense metal component. The objective of this research is to develop a Laser Aided Metal Deposition System (LAMDS) capable of forming near 100% dense three-dimensional objects directly from CAD drawing.  The project will develop a fundamental understanding between the process parameters for laser aided metal deposition of H13 steel with deposit dimension with 10-100 micron accuracy, microstructure and mechanical properties.   The research project has a balance between theory and experiment, and will provide valuable findings for the tools and dies manufacturing industry.

Regents of the University of Michigan - Ann Arbor


CYTOPLASMIC ACTIVATORS OF HUMAN MUSCLE GENES


Complement and Inflammatory Factors in AD Pathogenesis


ADVANCED MCP UV VISIBLE DETECTOR SYSTEMS

National Aeronautics and Space Administration


Toward Gravitational Wave Discovery with Advanced LIGO

The UWMLSC group will contribute several critical elements to create a low-latency streaming on-line search for transient gravitational waves, such as those produced during the coalescence of binary neutron stars or black holes, the most anticipated gravitational wave signal. Among the data analysis elements we will create are the streaming data calibration system, a low-latency system for determining data quality and glitch vetoing, and on-line searches for signals from inspiralling compact binaries and for generic unmodeled bursts. Such a system to rapidly identify signals will be an essential element of gravitational wave science in the Advanced Detector Era, and will enable multi-messenger astronomy in which observations of several kinds (gravitational waves; electromagnetic waves; high energy particles) are synthesized to obtain a detailed understanding of the sources of the most cataclysmic events in the universe. Gravitational wave astronomy will reveal the inner mechanism of the mysterious gamma ray bursts, will provide a means to measure the population of black holes and determine the channel by which massive black holes are grown, and will probe the fundamental nature of matter above nuclear densities. New ways of measuring cosmological parameters will become available, which will complement existing observations. Gravitational wave observations will also provide sensitive tests of Einstein's General Relativity in ways in which it has not yet been scrutinized. The opening of the gravitational wave window onto the universe can potentially evince exotic objects such as naked singularities, cosmic strings, or unexpected physics. We must be ready to address these scientific challenges as our new astronomical facilities come into operation. To this end, this award will support work that may result in the first gravitational wave discoveries of compact binary coalescence, provide rapid sky localization to facilitate electromagnetic follow-up efforts, yield fast turn-around targeted searches prompted by triggers generated by other observational facilities, obtain the the nuclear equation of state by measuring the tidal interactions of binary neutron stars just prior to their merger, observe black hole formation channels and probe fundamental properties of black holes through their quasi-normal modes of oscillation, scan the sky to find undiscovered rapidly rotating neutron stars and to learn about their properties, test cherished principles of gravitation such as the no-hair and cosmic-censorship conjectures, and seek new exotic and unexpected phenomena.

Our work supports the creation of critical components of a system that will allow the rapid transmittal of gravitational wave observations to the entire community of astronomers, and facilitates the integration of gravitational wave science into the broader field of astrophysics. The group has a solid track record of educating new researchers; this project will have a broad impact by training a new generation of graduate students, postdoctoral fellows and junior faculty members in gravitational-wave astronomy, as well as conveying the excitement of this budding branch of astronomy to the community through outreach efforts such as the UWM Planetarium.


Smart Renewable Energy Manager for the Industrial Prosumer Market

The progressive reduction in price of renewable energy and energy storage due to technology innovation and production enhancements is revolutionising the energy sector by turning the traditional centralised power system into a new decentralised one. Commercial and industrial (CI) consumers are increasingly implementing distributed energy resources (DERs) such as solar photovoltaic (PV), local batteries and electric vehicle (EV) charging stations in their facilities to lower their energy cost, increase security of supply and decarbonise the economy.By implementing an increasing number of DERs, CI consumers become prosumers (producers and consumers). Prosumers must manage their own generation, storage and consumption. Therefore, there is an urgent need to develop energy management tools able to cost-effectively integrate and operate generation, storage and loads. Moreover, new opportunities to make profit arise with the implementation of DERs (especially from the potential of the pair distributed generation plus storage) regarding the traditional scheme.SREM is an innovative Smart EMS specifically designed to fill the need to automate the management of loads and the increasing number of DERs in the CI market. Its differentiating and proprietary algorithms aim to achieve the highest financial return (15%-30% energy savings). SREM has been developed by Effinnova Management (Effinnova) a Spanish start-up company that is providing substantial economic savings through energy management services to its industrial and commercial customers and that has noted its customers urgent need to develop new energy management tools to integrate a growing number of DERs in their facilities aiming to reach economic gains, facilitate its operation  control and increase the security of supply. The benefits that this technology will bring to the market will make the proposed project profitable with a ROI of 7 over 5 years and a payback period just above 2 years.


13世紀から16世紀までの中央ユーラシアにおけるテュルク（トルコ）民族の歴史

Principal Investigator：川口 琢司, Project Period (FY)：1999, Research Category：Grant-in-Aid for Encouragement of Young Scientists (B), Research Field：歴史


Pre-College Teacher Development in Science


GOALI (Faculty in Industry):  Powder Technology

Prof. D.J. Quesnel will conduct research work in the area of particle technology and  prepare a related short course during a sabbatical year visit at the Elmgrove Facility of Kodak Co.  Six related research/education areas will be considered at the beginning of the visit, including powder flow, toner dusting, toner transfer, fine toner handling, molecular dynamic study of particle adhesion, and training in powder mechanics.  Based on that experience, the P.I. will focus his activities on a major research thrust in the second part of the visit.  This is a GOALI Faculty in Industry proposal.    It is expected that the visit will foster long term collaboration between the University of Rochester and Kodak Co., with benefits for both research and educational programs on powder technology.


MATERNAL MORTALITY EFFECTS OF ABORTION LEGALIZATION


Exploiting Genetic Diversity of Essential Micronutrients in Duckweeds for Human Nutrition

Duckweeds are fast growing aquatic plants that have excellent nutritional qualities (high protein content, valuable omega-3 fatty acids and essential micro-nutrients), suggesting high potential for human and animal nutrition. Recent research suggest that there is a significant genetic variation for these nutritional qualities in different species and even intraspecific duckweeds. However, the genetic basis of such variation in duckweeds remains unclear. We aim to pinpoint the genetic basis underlying the variation of nutritional qualities in duckweeds towards developing toolkit for selecting suitable duckweed genotypes for future applications in human and animal nutrition. In this DTP studentship, we will primarily focus on the nutritional quality of essential omega-3 fatty acids and amino acids, which are important in a wide variety of physiological processes in human and animal health. Same as originally submitted except we have included Amino acid profiling along with the fatty acids.

Biotechnology and Biological Sciences Research Council


ICU-ROOM : Intensive Care Unit Rooms, Objectified, Observed and Measured.

Intensive Care Units (ICU) are the places in hospital where the sickest patients are treated. Complications of treatment in ICU are common. We found one in four patients in Canadian ICUs have a treatment-related complication - an adverse event. Examples include: new infections, medical devices 'falling out' and skin breakdown. Each year tens of millions of dollars are spent to improve patient safety by reducing adverse events. Our recent review suggests that the way ICUs are designed effects how care is provided to patients and contributes to adverse events. Building an ICU costs tens of millions of dollars, and happens every 20-40 years. It seems sensible that ICU design should be focussed on helping ICU professionals provide safe, high-quality care minimizing complications and providing the best possible experience for family members when visiting their loved one. In this project we want to find out HOW ICU design affects patient safety - we will measure adverse events. We will also ask ICU professionals and patient's loved ones about their experiences working in and visiting these 200 bedspaces in ICU's across Canada. Common sense tells us things like how big patient rooms are, how far rooms are apart, how close key equipment is, the quality of amenities for visitors, and how well patients and patient-monitors can be seen from nursing stations are important. Common sense also suggests that ICU professionals are resourceful and adapt to overcome challenges - including those related to ICU design. Knowing what happens in the real-world is important: bedspace types linked to the most adverse events can receive extra attention to reduce risk to patients. Architects can avoid unfavourable features as they design new ICUs. Bedspace types linked to the least adverse events and the most favourable visitor experiences can be built into future renovations and new designs - to improve the outcomes of critically ill patients across Canada and around the world.


白血病誘発機構に関する研究

Principal Investigator：渡辺 漸, Project Period (FY)：1971, Research Category：Grant-in-Aid for Cancer Research

Japan Society for the Promotion of Science


Post-growth and sustainability: imagining and experimenting with balanced artistic models

The IMAGINART project proposes to imagine and experiment with balanced artistic theories and practices to respond to the ecological crisis, which is at once environmental, social and mental. To do this, it mobilises two concepts that are able to cross these three ecological registers, (1) the degrowth in resources, thought of as a way to achieve a post-growth society and (2) the sustainability of technologies, i.e. the invention or use of more sustainable technologies. IMAGINART focuses on music / sound arts and digital visual arts, whose creative mediums are highly dependent on technological and energy resources. The project is interdisciplinary, bringing together researchers in the arts and researchers in post-growth. It adopts a methodology that combines fundamental research and research-creation. It is composed of 5 WPs that are interdependent while being dedicated to differentiated tasks: -WP 0 is dedicated to the management and coordination of the project; -WP 1 is designed as the foundation of the project, dedicated to fundamental research (and action research): its mission is to conceptualise and theorise post-growing artistic practices and sustainable artistic technologies, as well as to conduct a field survey to gain an overview of the state of the art, complementing the developments specific to the project; -WPs 2 and 3, dedicated to research-creation, are complementary. WP 2 consists of residencies for guest artists, conceived as places conducive to the emergence of balanced artistic solutions. Based on the ideas that emerge in WP 2, WP 3 focuses on the means of artistic production by developing and experimenting with post-growing and sustainable tools, then considering the artistic performances that will use these tools. These two WPs interact with WP 1 throughout the project; - WP 4 is responsible for the documentation and dissemination of the project. The project is coordinated by Makis Solomos (MUSIDANSE, 50% FTE), honorary member of the IUF, Professor of Musicology at the University of Paris 8, specialist in contemporary music and sound arts, in the music of Xenakis, and in the ecology of sound and music (his book Exploring the Ecologies of Music and Sound was recently published by Routledge). The other scientific responsibles are: Jean-François Jégo (AIAC/INREV, 25% FTE), artist-researcher, Senior Lecturer in the Department of Image Arts & Technologies at the University of Paris 8; João Fernandes (CEAC, 25% FTE), artist-researcher, Senior Lecturer in the Music Department at the University of Lille; Christine Esclapez (PRISM, 25% FTE), Professor of Musicology at AMU; Angelos Varvarousis (ICTA-UAB, 17% FTE), specialist in degrowth, Senior Researcher Fellow at the University of Barcelona. The laboratories involved are: MUSIDANSE (University of Paris 8), specialising in musical or sound creation; the INREV team of the AIAC laboratory (University of Paris 8), which experiments with and theorises research-creations on the relationships between digital visual arts and the performing arts; CEAC (University of Lille), which aims to explore contemporary creative processes and forms; PRISM (AMU), specialising in research-creation and epistemology of arts/sciences interactions; the Institute of Environmental Science and Technology (ICTA-UAB, Spain), which includes world specialists in post-growth. The project has academic, artistic, educational, social and ecosophical (combining the three ecological registers) impacts.

Institute of Environmental Science and Technology (ICTA-UAB)


CELLULAR CALCIUM REGULATION IN MYOPATHIC HEARTS IN VITRO


Metabolic Studies of Low Density Lipoproteins


Die Bedeutung der Ross/panafrikanischen Orogenese im Bereich Kirwanveggen/Sverdrupfjella (Neuschwabenland)

Im Rahmen der südafrikanischen "Earth Sciences Expedition to western Dronning Maud Land 1997/98" wurde als Teilprojekt eines der Hauptforschungsziele der Antarktisgeologie "Supercontinent assembly and dispersal: Antarctica and global geoynamics" die Bedeutung der Ross-/panafrikanischen Orogenese im Raum Kriwanveggen/Sverdrupfjella (Westneuschwabenland) untersucht. Dies erfolgte in erster Linie mit strukturgeologischen Methoden und durch den naheliegenden Vergleich mit entsprechenden Ergebnissen des Antragstellers in der Shackleton Range. Anhand der im Gelände gewonnenen strukturellen Daten und dem umfangreichen Probenmaterial sollen Alter und Deformationsentwicklung von Überschiebungssystemen in Süd- (Polaris Ridge-Region) und Zentral-Kirwanveggen (Tverregga) sowie der Urfjell-Gruppe geklärt werden. In den entsprechenden Einheiten sollen sowohl ross-orogenetische Einengungsstrukturen als auch Orogene-Kollaps-Indikatoren wie LANFs und Knickbänder analysiert und bewertet werden. Schließlich soll versucht werden, Spuren der Westfortsetzung des Mocambique-Ozeans nachzuweisen, denn in der Shackleton Range konnte dieser Nachweis inzwischen erbracht werden.


ラジアル型超伝導軸受を用いたリニアアクチュエータのファジィ制御

Principal Investigator：小森 望充, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：電力工学


DEMONSTRATION OF NOVEL TECHNOLOGY TO PROVIDE PHYSIOLOGICAL MONITORING OF PATIENTS WITH TRAUMATIC BRAIN INJURY DURING INTENSIVE OUTPATIENT PROGRAM

UNIFORMED SERVICES UNIVERSITY MEDICAL RESEARCH PROJECTS


カイコの笹繭形質の原因遺伝子の解明とその応用

「笹繭」は、繭にフラボノイド系の色素を蓄積する形質であり、複雑な遺伝的支配を受ける。私たちの研究室は、すでにGb遺伝子の単離に成功したが、本研究では、別の遺伝子の探索と遺伝分析を進めた。古くから、笹繭形質にはZ染色体に連鎖するGre(緑卵)遺伝子が関与していることが知られているので、この遺伝子のマッピングを進めた。すなわち、o06×(o06×f04)の交雑後代をDNAマーカーで分析したが、原因遺伝子の特定には至らなかった。一方、Gre遺伝子の機能を解明するため、正常卵(+^<Gre>)の系統と緑卵(Gre)の系統の間で、紫外線に対する抵抗性を比較した。すなわち、+^<Gre>とGreの浸酸卵をそれぞれ屋外に6日間放置し、孵化率を調査した。その結果、+^<Gre>はまったく孵化しなかったのに対し、Greの卵はほぼ正常に孵化することが判明した。カイコの野生種であるクワコがGre遺伝子を持っていることを合わせて考察すると、+^<Gre>は本来持っていた卵殻の紫外線防護能を喪失した変異体であると考えることができる。尿酸は、メラニン、オモクローム、フラボノイドなどとともに、カイコの体色を構成する重要な物質である。尿酸の蓄積が減少するoal斑油の形質は、oal(2-27.9)とmu-oal(mutator of oal ; 13-40.4)の両遺伝子が共にホモ接合になった場合だけに現れる。昨年度、九大o10系統(p oal, mu-oal)と東大p50T系統(+^P +^<oal>,+^<mu-oal>)の間で多型を示すPCRマーカーを多数開発するとともに、(p50T×o10)♀×o10♂の後代、姫蚕かつ斑油の♀と姫蚕かつ非斑油の♂とを交配し、次代の斑油個体と正常個体をPCRでジェノタイピングした。その結果、mu-oalの原因を第13染色体上の176kb内に絞り込んだ。本年度は、この範囲に存在する予測遺伝子8個について、mu-oalと+^<mu-oal>の間で比較を行い、候補を探索した。


PRECHRONIC TOX STUDIES OF SODIUM SELENITE AND SELENATE


Cellular and Molecular Biology Training Program


Structural Biology of Prokaryotic NO Synthases

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON


Pharmacokinetics of Risperidone Across Pregnancy

PROJECT NARRATIVE Evidenced-based data that maximize drug efficacy and minimize fetal exposure across pregnancy is necessary to optimize maternal wellness and birth outcomes. Investigation of drug concentration across pregnancy informed by physiological changes in pregnancy, as well as, the impact of genetic differences on drug response are the building blocks to personalize medication management for pregnant and postpartum women with mental illness.


Collaborative Research: Project Incubation - New Jersey Institute of Technology Campus Alignment Review of Ethics

Today’s US citizens need to be competent evaluators of scientific and technical claims that they encounter through social media, news stories, or professional communication. Their ability to identify and use verifiable facts impacts their personal choices and their active participation in public discussion. Professionals in scientific and technical careers need to approach their work with an understanding of ethical considerations, which include how the professional choices that they make in the face of ongoing and novel challenges impact citizens’ everyday lives.  Given the broad social impacts of scientific and engineering research, ensuring the ethical and responsible conduct of research is vital to the welfare of the American public and promotes the progress of science. Universities must meet this need, both as sites of research and, most critically, as educators of future STEM researchers and workers. In this project, researchers examine how well institutional messaging that describes New Jersey Institute of Technology’s commitment to ethics aligns with students’ encounters with ethics in and out of the classroom. Ethics education aligns with the critical evaluation needs of citizens in two ways: first, by ensuring that the scientific and technological researchers of the future come to their work with robust training in ethics and next, by ensuring that higher education gives students practice in ethical reasoning. Skill in ethical reasoning facilitates students’ personal, vocational, and civic growth. Lessons learned from this study at this university will be used to improve alignment of ethics education at other US universities.

Researchers from Harvard University, Stanford University, and the University of South Florida who are members of a research consortium, the National Ethics Project (NEP), join forces with investigators from New Jersey Institute of Technology (NJIT) to build an evidence-based account of an institution’s commitment to ethics education. Employing mixed-methodologies, we will test tools and techniques that combine novel and traditional methods from the digital humanities, psychology, and design thinking. These tools were designed by the NEP to benefit a broad range of institutions of higher education in auditing and transforming approaches to Ethical and Responsible Research. For this project, we will focus on alignment: identifying consistency with institution, faculty, and student statements and perceptions that include instructor goals, activities, and assessment techniques, student perception, and stated institutional commitment to ethics. In addition to helping NJIT examine its own approach to ethical and responsible research and seeding a future Institutional Transformation proposal to address identified needs, this project is the first campus-wide opportunity for the NEP to fully test its Campus Alignment Review of Ethics, which to date has been applied only piecemeal on separate campuses. Results from this research will be disseminated via the NEP website, the National Academy of Engineering’s Online Ethics Center, scholarly presentations at national conferences and publications in scholarly journals. Data developed through this project will be available to other researchers and to the public through the Open Science Framework.

This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.


Decay of Cosmic Ray Particles at Sea Level


Water resistance: a study of environmental justice, resilience and citizen science activism in Mexico City

This research will explore resilience in the context of environmental justice, with a focus on water insecurity in Mexico City. The concept of resilience is central to public health and climate change discourse, but is rarely critiqued. Addressing this omission is crucial: resilience frameworks can conceal social inequalities, uphold political status quo, and overlook local experience. Equally, few anthropological studies have examined resilience and urban water insecurity. In Mexico City these gaps are especially prescient. The third most water-stressed city in the world, low-income neighbourhoods have limited access to water. Communities often protest in response. Drawing together an ethnographic study with the digital participatory methods of citizen science, the goals of this research are to: • Understand the meaning and practices of resilience amongst people who experience water insecurity. • Investigate the role of digital technology and citizen science in this space. • Inform future uses of resilience in environmental justice research, design and policy. Through these objectives, the research acts at the intersection of social inequality, public health and the environment. The outcomes will contribute to anthropological theory and knowledge, open the potential for trans-disciplinary collaborations, and bring a more sensitive and ethical perspective to the overlap of climate change and health.


Arizona State Public Information Network (ASPIN)            Connecting Navajo Community College

9522611  Brand      This project establishes a Network Information Center at two campuses of the Navajo Community College, and will work toward developing a virtual campus linking all seven campus sites in the Navajo Nation.  The eventual goal is to enable "attendance" at Navajo Community College at any of the 111 communities within the Navajo nation.  Connectivity to the Internet for the Community College is being provided by Westnet and New Mexico Technet under another award.  Duration of this award is two years.


Re-Sounding Voice Assistants: Histories of Gendered Interfaces, Politics of Disembodied Voices

Social Sciences and Humanities Research Council of Canada


Imunomodulação associada a transfusão de sangue alogênico e singênico

Transfusão de sangue alogênico é associada a crescimento de tumores em animais devido a efeitos imunomodulatórios. Os mecanismos desse fenômeno não estão completamente definidos. Nesse projeto será investigada a cinética de elevação de interleucinas em unidades de sangue alogênico e singênico não modificadas, e submetidas a graus variáveis de desleucotização com filtros leucocitários. Além disso será analisado o efeito da radiação gama na produção de interleucinas. (AU)

Fundação de Amparo à Pesquisa do Estado de São Paulo

Auxílio à Pesquisa - Programa Cooperação CNPq-FAPESP

Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM)


MOLECULAR STUDIES OF MUCIN EXPRESSION IN CYSTIC FIBROSIS


糖尿病患者における高感度CRP測定の意義

Principal Investigator：野口 早苗, Project Period (FY)：2003, Research Category：Grant-in-Aid for Encouragement of Scientists, Research Field：医学

Japan Society for the Promotion of Science


Western Asian Alienation: Analysing the Messaging Around Multiculturalism and Diversity to Respond to Anti-Asian Racism in B.C.


Kinetik der Staubbeladung in Tiefenfiltern

Gegenstand dieses Forschungsvorhabens ist die Untersuchung der Staubbeladungskinetik in Tiefenfiltern im Bereich der Trägheitsabscheidung. Aufbauend auf den bisher gewonnenen grundlegenden Ergebnissen zur Staubbeladungsverteilung und zum Durchströmungsverhalten sowie zur Abhängigkeit dieser und der Filtrationskenngrößen Trenngrad und Druckverlust von Betriebsparametern, sollen im zweiten Teil des Vorhabens die Modellbildung und hierzu zielgerichtete Detailmessungen im Vordergrund stehen. Weil sich eine geschlossene mathematische Herangehensweise über sich mit der Staubbeladung ändernde Einzelfaserauftreffgrade, -haftanteile und -abscheidegrade als nicht sinnvoll erweist, da formelmäßig die sehr komplexen Partikelstrukturanlagerungen nicht berücksichtigt werden können, soll hier ein makroskopischer Ansatz, der die im ersten Teilabschnitt des Vorhabens gesammelten experimentellen Erkenntnisse hinsichtlich Einflußgrößen auf die Filtrationskinetik berücksichtigen kann, gemacht werden. Über eindeutige strukturgeometrische Eigenschaften und Staubmassenverteilungen in Abhängigkeit von Betriebsgrößen und Partikeleigenschaften soll eine Zuordnung zu einer charakteristischen Staubmasse und einem zu berechnenden Druckverlust erarbeitet werden. Hierbei baut der vorliegende zweite Abschnitt des Vorhabens Ka 1373/3-1 einerseits auf Daten aus dem Teilprojekt B2 der von der DFG geförderten Forschergruppe "Anwendungen der Magnetischen Resonanz zur Aufklärung von Strukturen und Stofftransportprozessen in dispersen Systemen" und andererseits auf die im ersten Teilabschnitt des vorliegenden Vorhabens gewonnenen Ergebnisse auf.


脱塩基オリゴDNAを用いた表面プラズモン共鳴による一塩基多型検出

遺伝的先天性疾患の診断を目的として、個々人のDNA配列を解析することの重要性が高まっている。特に、DNA配列内の一塩基多型(Single Nucleotide Polymorphisms, SNPs)検出法の開発は、個人個人に最適化された「テーラーメイド医療」の実現に向けて重要な研究課題の一つである。これまで、蛍光検出型DNAマイクロアレイが主に開発されてきたが、標的DNAへの蛍光ラベル化などの煩雑な操作が必要であることが問題とされており、これに代わる迅速、簡便かつ安価な手法の開発が期待されている。本研究では蛍光ラベル化を必要としない手法として、金電極表面に固定化した脱塩基部位含有DNA単分子膜への水素結合性小分子の結合について検討を行った。DNA単分子膜上に吸着したチトクロムcの電気化学応答を計測したところ、水素結合性小分子存在下で良好な電気化学シグナルが得られたのに対して、非存在下では電流量の減少並びに応答の鈍化が観測された。これはチトクロムc-電極間の電荷移動に対するDNA中の脱塩基部位の影響であると考えられる。また、脱塩基部位向かい側の標的塩基に対しても電流応答の依存性があることがあきらかとなった。用いた水素結合性分子であるナフチリジン誘導体と相補的な三点水素結合形成をするシトシンにおいて最も良好な応答が得られたことから、脱塩基部位への水素結合性分子の結合ならびに脱塩基部位向かい側の標的塩基の識別をチトクロムcをレポータ分子として読み出すことに成功した。現在表面プラズモン共鳴分光法による評価について検討中である。


Development of Analytical Methodology for Urban Meticulous Spatial Structure and Material Stock with Satellite Image Data 〜Application for Urban Environmental Planning〜

High-resolution satellite image data that has been available recently might be useful enough for analyzing vegetation in urban zone. In this research, firstly, two types of satellite image data are compared. One is IKONOS that is expected to be more common in several studies, the most detailed currently. The other one is LANDSAT that has been used frequently for precedent urban vegetation land-use analysis. As for urban space is finite, to give the residents a feeling of satisfaction, Land Planner should grasp accurate measurement of urban land-use pattern and vegetation indexes and make a sophisticated plan to realize it. So secondly, with the soft ware of ERDAS, we analyze distribution situation of rather large-scale green field as park zone, roadside tree, private garden and rather detailed vegetation zone in Nagoya and Saga City. Furthermore, the vegetation calculation indexes, GCI, GDI are proposed here. The main results are as below ;1. The vegetation distribution of the surface of Nagoya city is distributed roughly relatively than one of Saga City.2. The vegetation around the commercial land-use zone is however comparatively concentrated though the degree of green is rather short.3. The vegetation around the residential land-use zone is however relatively dispersed though the degree of green is rather large.These tendencies might be caused from the existence of much detailed, discontinuous and segmentalized vegetation zones as private gardens over Nagoya urban district.

Grant-in-Aid for Scientific Research (B)


HLA-E restricted T-cell immunity in Mycobacterium tuberculosis infection

Antigen presentation of Mtb epitopes to antimicrobial CD8+ T-cells by monomorphic evolutionary conserved, non- classical HLA-E molecules is a novel avenue for inducing protective immunity against TB through innovative vaccination strategies. We therefore aim to define in detail the molecular interactions between HLA-E, Mtb peptides and T-cell receptor molecules, and to characterize HLA-E restricted T-cell responses against these peptides during infection and disease, as well as following vaccination or controlled human mucosal (aerosolized BCG) infection, and dissect the functionality of this highly conserved system. This knowledge will innovate our understanding of the role of these newly discovered T-cells in mycobacterial infection and disease, and pave the way towards harnessing this knowledge for future improved TB vaccine design, thus contributing significantly to NIH’s mission to protect human health.


学習設計のスキルを深めるための「学びほぐし」を取り入れた活動の提案

本研究の目的は、教授設計の学習活動に学びほぐしの活動を中心とした、学習活動の支援手法を構築することにある。「学びほぐし」「ゲーム学習」「リフレクション」の３つの研究知見を組み合わせ、教授設計スキルの向上を狙う点に本研究の学術的独自性と創造性がある。


Methods for studying treatment heterogeneity using large observational databases

We propose a multi-phase program of research to develop, validate, apply and disseminate methods for predicting individual level heterogeneity in effectiveness and safety (for a range of patient/clinician identified outcomes of interest) for observational comparative effectiveness research. The proposed program of research will translate theory to practice, and produce a template for clinical decision support tools that could be used to facilitate personalized medicine and help patients make informed healthcare decisions based on their personal characteristics, conditions and preferences. The decision aids could be used during the office visit to help physicians and patients discuss expected risks and benefits that are particular to each patient at a "critical moment", when the treatment decision is being made. As more evidence on patient identified priority topics is generated, the template would be readily adaptable for communicating new evidence to patients and their providers.


We shall study various questions in Analytic Number Theory. Our basic long term goal is the acquisition of new and important results about the distribution of the prime numbers. Aside from raising fascinating questions about the properties of these most special numbers and occupying the interest of many of the giants of the subject, the area has achieved central importance within mathematics due to the strong ties which link the techniques of proof to many (actually most) of the other branches of the subject. It also has not hurt that in the past quarter century the topic has found crucial applications in public-key cryptography and hence to issues of internet security. Closely connected to the distribution of prime numbers and of continuing fundamental interest to the proposer are the topics of sieve methods and $L$-functions.  Among the particular topics we plan to consider are: 1) distribution of primes in arithmetic progressions  2) theory and applications of sieve methods  3) quadratic problems in number theory: character sums and $L$-functions 4) coordinate distribution of Gaussian primes 5) applications of "spin" 6) distribution of ``smooth'' numbers  In each case we have more than one specific problem in mind. Some of these overlap  two or more of the above headings. Some of these are suitable for graduate  students or postdoctoral fellows.

Natural Sciences and Engineering Research Council of Canada


RANDOMIZED TRIAL ON THE CLINICAL MANAGEMENT OF


Inhibition of Glioma Growth by a Novel Molecule


Narrative Skin barrier dysfunction and inflammation are strongly linked with food allergies. In particular, food allergies are associated with B cells that infiltrate the skin, yet the precise role of these skin-associated B cells in disease pathogenesis remains unclear. Food allergies are a growing national public health concern and carry a high risk of life-threatening allergic reactions. There is no treatment to prevent or cure food allergies. Thus, understanding the immune mechanisms that cause sensitization to foods is essential for identifying new treatment strategies that can be used to stop allergic reactions. This proposal explores the immune mechanisms by which skin-associated B cells lead to sensitization and the development of food allergy to red meat. The outcomes from these studies will yield novel mechanistic insights that can inform our thinking of new ways to design effective therapies for the treatment of food allergies.


ATYPICAL ANTIPSYCHOTICS AND P50 GATING IN SCHIZOPHRENIA


フィラリア感染における免疫複合体の形成とその病態生理に及ぼす影響

Principal Investigator：月舘 説子, Project Period (FY)：1985, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：寄生虫学(含医用動物学）


MRIと造影剤を用いた脳血流量測定法の確立:PET測定との対比による

本研究では、定量性がすでに良く知られているPETによる脳循環測定との比較を通して、MRIとガドリニウム造影剤を用いた脳循環測定法を確立することを目的とする。まず本年度は、前年度に得られたMRIにおいて造影剤遅延補正を行うことにより両手法でより近い脳血流量が得られる、という結果をまとめて論文投稿を行った(Magn Reson Med Sci.)。これまでは、血管障害の症例においては造影剤の到達遅延に伴い、デコンボリューション解析に誤差が生じることが指摘されてきたが、本研究は健常成人においても到達時間の脳内局所差がわずかではあるが存在し、これがMRIによる脳血流量測定に影響を与えることを示した点で有意義であると考える。さらに今年度は、MRI撮像方法に関する検討を進めるため、スピンエコーEPI法(SE法)よる予備的な測定を行った。これまでのグラディエントエコーEPI法(GRE法)による測定と比べ、平均血管内通過時間(MTT)に関してはより小さな値を示す傾向が見られたが、SE法による測定はGRE法に比べMR信号の変化が小さいため、詳細な検討のためには測定条件の最適化を推し進める等が必要であると思われた。また今年度は昨年度に得られたデータの更なる解析を行い、両手法により得られたMTTの差異について検討を行った。データ解析には、昨年度に整備した処理系・補正法を用いた。健常成人のMTTは、灰白質より白質おいてより大きな値を示すことがわかった。両手法によるMTTの違いは局所性に関しては少なかったが、MTTの絶対値としてはMRIの方が約30%小さかった。原因の一つとして、両モダリティ(PET、MRI)の測定感度の血管成分依存性が異なることが推測された。この研究成果は、国際脳循環代謝学会(Brain05)で発表しており、現在論文投稿中(査読中)である。

Research institute for Brain and Blood Vesseis Akita


PHOSPHOLAMBAN MODULATION OF SMOOTH MUSCLE CONTRACTILITY


Comparative Analysis of the Legal Framework for Asset-Backed Securitisations in the United States and in Switzerland.

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Institution abroad - United States of America


BIO-OPTOELECTRONIC NOSE: A NOVEL PLATFORM FOR ORTHOGONAL CHEMICAL SENSING


Biogeochemical assessment in critical zones of contaminated urban area: EACH, Campus Capital USP East

The expansion of the urban limits does not only represent impacts related to land use and occupation, but promote changes in several other elements of the Earth system, promoting a synergy of environmental problems that should be the object of evaluation, magnification, monitoring, etc. When considering the assessment from the perspective of critical zones, where rock, soil, water, air and living organisms interact, negative externalities are reflected in the provision of ecosystem services and are often not perceived by the local and surrounding community. The conurbation promoted by urban expansion between the municipalities comprising the Metropolitan Region of São Paulo - RMSP and Macrometrópole Paulista (MMP) promoted the reduction (sometimes the disappearance) of the rural border areas, and in some points, they advanced into areas that should be protected. Complex interactions and connectivity in critical zones require an interdisciplinary approach to assessment and monitoring over long periods to understand the dynamics of processes and variables, in temporal and spatial scale. The objective of this project is to integrate different approaches to establish biogeochemical coefficients, from the plant-soil-water interaction in the critical zone, and to understand the patterns of seasonal evolution of vegetation in the critical zone. The study will be developed through the implementation of pilot critical zone observatories, involving partners for research, and a joint approach to geophysical methods, atmospheric parameters, geochemical and socio-environmental assessment. (AU)

Fundação de Amparo à Pesquisa do Estado de São Paulo

Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH)


Universidade Estadual Paulista (UNESP). Campus de Ilha Solteira. Faculdade de Engenharia (FEIS)


Development and basic research of comprehensive screening index for oral frail caused by hospitalization

We conducted a survey on Oral and Frailty conditions for Hospital nurses and the elderly, and developed an educational program for fostering human resources for Oral and Frailty prevention as well as assessment indicators for the prevention of Oral and Frailty inpatients.In this study, When it was decided to be hospitalized, it was considered necessary to provide guidance for the prevention of Oral and Frailty in inpatients through cooperation with the primary dental clinic. In addition, in cooperation with dental stuff, Hospital nurses need to grasp the oral condition and assess Oral and Frailty of inpatients and take appropriate measures promptly. In addition, it was considered necessary for dentists to provide nursing staff with guidance on Oral and Frailty assessment and treatment.

Japan Society for the Promotion of Science

Kanagawa Dental University Junior College


No summary - Aucun sommaire


The role of cellular factors in the HIV-1 capsid assembly pathway


The Socorro Magma Body:   Surface Uplift History and Crustal Dynamics

The Socorro magma body, which was identified by geophysical methods, is one of the largest known magma bodies on Earth. It is a tabular body approximately 3,400 square kilometers in area and less than 150 m thick situated at about 19 km depth below Socorro, New Mexico, within the Rio Grande rift. The area has the highest rate of upper crustal seismicity in New Mexico, activity, which presumably is triggered by deformation and ascending hydrous fluids above the Socorro magma body. Leveling and InSAR studies indicate that the magma body causes surface uplift at rates of as much as 2.5 to 3 mm/yr. By mapping and dating surface features in this project, researchers from New Mexico Institute of Mining and Technology can constrain the age and uplift history of the magma body. When coupled with numerical modeling, the results will improve understanding crustal growth, magma genesis, and stress changes during rifting. The project advances desired societal outcomes through full participation of women in STEM through support of an early career female PI, increased public scientific literacy and public engagement with science and technology through outreach efforts, improved well-being of individuals in society through better understanding of earthquake and volcanic hazards in New Mexico, development of a competitive STEM workforce through training of undergraduate and graduate students and support of an early career researcher.

The Socorro magma body affords a rare opportunity to study a mid-crustal magma body (most others are much shallower), to relate mid-crustal processes to surface deformation, to study the effects of a deep sill on extensional processes, and to study magmatic crustal growth in rifted crust. The overarching goal of this project is to determine the long-term history of the Socorro magma body through a combination of geomorphoological mapping, surface exposure dating, and geodynamic modeling. The project determines: (1) if the magma body has a history longer than about 1 ka; (2) episodicity and ages of inflation; (3) changes in the locus of surface deformation through time; (4) relationship between surface faulting and the magma body; and (5) geometry of uplift sources. Specifically, the research team maps and correlates terraces formed along the Rio Grande and its tributaries for use as strain markers. Socorro magma body-related and Quaternary fault-related surface deformation is distinguished based upon differences in expected tilt directions, length of tilting, and magnitude of tilting. Terrace correlation involves relative heights above streams, characteristics of terrace treads, deposits and straths, and soil analysis. Key, well-preserved terraces are dated using the 36Cl depth-profile method. Geodynamic modeling tests the geometry and dynamics of the active uplift source (inflation, thermal expansion, feeder source, contraction of crystallized magmas, etc.) by comparison with InSAR and GPS results, and guides interpretation of past episodes of Socorro magma body surface deformation revealed by the terrace analysis.


Precipitation and Defect Formation Processes in Oxygen      Implanted Silicon-on-Insulator Material

The purpose of the research is to understand the                           relationships between processing parameters and mechanisms of                   structural change in silicon-on-insulator material synthesized by               high-dose oxygen implantation into silicon.  The research uses                  transmission electron microscopy techniques to study the                        development of structure in thin "superficial" silicon layers                   above the buried oxide layer.  Specimens are processed using a                  variety of implantation and thermal treatments to allow following               of the formation of the microstructural changes.  Modelling for                 thermally activated processes of precipitation and precipitate-                 induced defect formation is based on bulk silicon models modified               for effects of damage from ion implantation, high oxygen                        concentration, and high defect density.                                                                                The research is relevant to understanding of the effects of                     oxygen, radiation damage, and mechanisms of ion implantation in                 silicon.


ルクセンブルク語における動詞の時制とアスペクト

Principal Investigator：西出 佳代, Project Period (FY)：2014-08-29 – 2015-03-31, Research Category：Grant-in-Aid for Research Activity Start-up, Research Field：Linguistics


Understanding the role of dysregulated synapsin II in the pathophysiology of schizophrenia

Affecting roughly 1% of the global population, schizophrenia is one of the most debilitating life long mental illnesses, costing an estimated $2.35 billion in treatment and management per year in Canada alone. Furthermore, current therapeutic treatment for schizophrenia through the use of antipsychotic drugs is associated with a myriad of undesirable side effects. Recent research on the underlying mechanisms of schizophrenia has focused on changes at the synapses of neurons, the regions through which nerve cells communicate with one another. The protein synapsin II has become a popular candidate potentially responsible for such synaptic changes. Decreases in synapsin II concentrations can be found in the prefrontal cortices of subjects with schizophrenia, indicating an underlying imbalance in synapsin II regulation. However, it has not been confirmed whether reductions in synapsin II are a causative factor in the development of schizophrenia or rather result from this disease. Research from my Master's studies has provided evidence that decreases in synapsin II may be responsible for the development of schizophrenic-like behaviors in a novel animal model. Furthermore, treatment with antipsychotic drugs can reverse behavioral changes induced by decreases in synapsin II, suggesting that the mechanisms of these drugs may involve synapsin signaling pathways. The goal of my research is to understand how decreases in synapsin II levels can interrupt dopamine and glutamate signaling, two neurotransmitters that are known to be imbalanced in the schizophrenic brain. Currently there is no cure for schizophrenia, and as previously mentioned antipsychotic drug treatment results in unacceptable side effects due to the manner in which these drugs interact with their target receptors. Understanding the role of synapsin II in schizophrenia may ultimately lead to new and more effective drug treatments, allowing these basic scientific results to translate to a clinical setting.

Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships


AIE-75 gene : with special reference to the differentiation of mucosal epithelial cells and the regulation of gene expression

Autoimmune enteropathy is a rare disease characterized by severe and refracrory diarrhea and the presence of circulating ants-enterocyte autoantibody. We have identified autoimmune enteropathy-related 75 kDa antigen (AIE-75) as a candidate autoantigen in the disease, which distributes to the brush border of both the small intestine and proximal renal tubulus. The distribution of AIE-75 is limited to the apical site of the villi, suggesting that the expression is regulated in cell cycle-or maturation-dependent manners. To approach this, we analyzed cis-element of the promotor region of AIIE-75 gene using luciferase assay, and found that -9 to -63 bases upstream of the transcription initiation site is involved in he negative regulation of the gene expression.The specificity and sensitivity of anti-AJE-75 antibody in autoimmune enteropathy were confirmed in collaboration with other groups. Furthermore, we identified an actin-binding protein, villin, as another autoantigen related to the disease.AIE-75 was found to be a responsible gene for Usher's syndrome type IC which is characterized by deafness and retinopathy. Indeed, AIE-75 was also expressed in both epithelial cells of the inner ear and retina. We found that ALE-75 is involved in the assembly of photoreceptor with cadherin 23 and myosin VII in the retina, but that the expression of AIE-75 is independent of the expression of the both proteins.Some cases of autoimmune enteropathy are inherited in an X-linked manner, named immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) of which cause is the mutation of a forkhead winged helix transcription factor, FOXP3. We found a novel mutation of FOXP3, T1117G, in a mild case of IPEX.


HISTAMINE MODULATION T-CELL IMMOBILIZATION IN THE LUNG


LGBTQ+ livelihoods:  uneven geographies of work and inclusion

Social Sciences and Humanities Research Council of Canada


39th European Physical Society Conference on Plasma Physics  16th International Congress on Plasma Physics

Universidade de São Paulo (USP). Instituto de Física (IF)


有理数体および〓上の代数関数体のガロア拡大体への保型関数の応用

Principal Investigator：小嶋 久祉, Project Period (FY)：1988, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：代数学・幾何学


3D Multi-Functional Catheter-Based Imaging of Coronary Lesion Composition, Structure, and Hemodynamics in Intermediate Stenoses

PROJECT NARRATIVE >200k people in the U.S. undergo cardiac catheterization for their stable coronary artery disease (CAD) each year to stratify risk of major adverse cardiac events in a patient population having a wide range of outcomes, with annual mortality rates varying by a factor of 6 between “low risk” and “high risk” stable CAD patients. Current imaging and non-imaging techniques for risk stratification and prediction of adverse events (such as myocardial infarction) based on independent indicators such as lesion structure and plaque composition are largely unsuccessful. By leveraging recent advances in ultrasound transducer array design, data reconstruction, high frame rate image formation, and catheter design, this project will develop an ultrasound imaging catheter designed to characterize the comprehensive coronary enviornment based on the full mechanics and hemodynamics surronding the stenosis.


MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM


IGF::OT::IGF COOPERATIVE AGREEMENT 2014 DUAL USE TECHNOLOGY DEVELOPMENT AT MARSHAL SPACE FLIGHT CENTER.

National Aeronautics and Space Administration


Vers l’utilisation de l’intelligence artificielle dans l’oncologie de précision


A knowledge-based message tailoring system

Project Narrative Healthcare professionals often receive inadequate feedback about their practice. We propose to build and evaluate intelligent software that uses psychological theory to customize feedback for individuals based on their characteristics and practice history, to increase the relevance of feedback for improving care. The successful completion of this project and future studies will lead healthcare organizations to make better use their data as performance feedback for improving health.


Peer effect, ranking effect and the distribution of talents among organizations


MEASURING QUALITY OF CARE FOR HOMELESS ADOLESCENTS


胎児期における糖代謝の特性に関する研究

Principal Investigator：今西 由紀夫, Project Period (FY)：1987, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Obstetrics and gynecology

Japan Society for the Promotion of Science


Maropack AG - to explore the value proposition and technical feasibility of blow-fill-seal for oral and injectable vaccines (IPV, Penta, HPV, PCV, Rota and Chole...

to explore the value proposition and technical feasibility of blow-fill-seal for oral and injectable vaccines (IPV, Penta, HPV, PCV, Rota and Cholera), including other pipeline vaccines in development


Studies on neural-inducing actions of bFGF to Xenopus ectoderm cells and their intra-cellular signal transduction mechanisms.

The vertebrate nervous system is initially induced from a section of dorsal ectoderm by signal(s) from the underlying dorsal mesoderm during gastrulation. In an effort to identify the neural inducing factor(s) emanating from the dorsal mesoderm, we have examined the inductive action of various growth factors by applying them to ectoderm cells from Xenopus gastrulae (8 to 12.5-hour age) in a microculture system that we have recently established. Monoclonal antibodies that specifically recognize cellular differentiation antigens from three distinct ectoderm lineages (N1 for CNS neurons from neural tube, Me1 for melanophores from neural crest and E3 for skin epidermal cells from epidermal lineages, respectively) were used as markers to monitor the differentiation of cultured ectoderm cells.We found that basic fibroblast growth factor (bFGF) was capable of specifically and reproducibly inducing gastrula ectoderm cells to produce CNS neurons and melanophores at physiological concentrations as low as 5 to 25pM.The induction of neural lineages by bFGF was accompanied more-or-less with the suppression of epidermal differentiation.The response of ectoderm cells to bFGF changed dramatically during gastrulation. Ectoderm cells from early (8 to 9-hour) gastrula gave rise to CNS neurons, but yielded few melanophores. As ectoderm cells were prepared from gastrulae of increasing age, their competence to form neurons was gradually lost, whereas the production of melanophores was enhanced and peaked in 11-hour gastrula. The ability to form both neurons and melanophores was substantially reduced in 12.5-hour gastrula. Further we showed that staurosporin, a potent inhibitor of protein kinase C, suppressed does-dependently both bFGF- and mesoderm-induced differentiation of melanophores, whereas it did not affect the differentiation of CNS neurons, indicating differential signal transdusing pathways in neural tube and neural crest inductions.


High-resolution Structural and Functional Brain Imaging of the Medial Temporal Lo

Public Health Relevance Statement  The population over 65 is projected to increase to 86.7 million by 2050 (U.S. Census Bureau, Population Estimates and Projections, 2004) and the impact of aging and aging-related disorders e.g. Alzheimer's disease (AD) on the health care system will rise dramatically as the rate of AD doubles for every five year period beyond the age of 65. Even outside of AD, one of the primary complaints and deficits observed with aging is a decline in learning and memory function, leading to decreased quality of life and a greater burden on families and social services. Understanding the neural mechanisms that underlie these age-related deficits is crucial to understanding the effect of aging on dementia, and paving the way to improving treatments for both normal and pathological changes in memory and for early prevention.


Principal Investigator：関口 定美, Project Period (FY)：1973, Research Category：Grant-in-Aid for Developmental Scientific Research


Hydrogen and Fuel Cells Demonstrations in Entertainment Industry

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


Soziale Arbeit als politische Akteurin (SAPAKT)

Die Transformation des Wohlfahrtstaats verändert entscheidende politische Rahmenbedingungen für die Soziale Arbeit. Doch die Soziale Arbeit nimmt als politische Akteurin auch Einfluss auf die Gestaltung dieser Rahmenbedingungen ihres Handelns. Die Frage, auf welchen Ebenen, mit welcher Legitimation, welcher Motivation, welchen Methoden und welchem Erfolg dies geschieht, ist wissenschaftlich bislang nur ausschnittsweise untersucht. Mit dem geplanten DFG-Graduiertenkolleg soll das politische Handeln Sozialer Arbeit (mit Blick auf individuelle wie komplexe Akteur_innen in unterschiedlichen organisatorischen Settings) sowohl (normativ-)theoretisch als auch theoriegeleitet empirisch analysiert werden. Der vorliegende Antrag zielt auf die Vorbereitung einer gemeinsamen Antragstellung für ein DFG-Graduiertenkolleg durch Wissenschaftler_innen von Fachhochschulen/Hochschulen für angewandte Wissenschaften und von Universitäten. Das geplante Kolleg soll dementsprechend kooperative Promotionen fördern und herausragenden Absolvent_innen beider Hochschultypen (Fachhochschulen wie Universitäten) exzellente, innovative Forschungsvorhaben ermöglichen. Die Zusammenarbeit kann dabei auf ein im Herbst 2016 abgeschlossenes, hochschultypenübergreifendes Promotionskolleg aufbauen. Sie ist auf den disziplinären Brückenschlag zwischen Politikwissenschaft, politischer Soziologie und erziehungswissenschaftlicher Sozialpädagogik angelegt.


Dengue risk mapping and immunization strategy in Japan

本研究はデング熱高蔓延地域であるベトナム中南部のニャチャン市で、対象コホートを複数設定する。対象コホート地域では人口学的データ、土地利用データ、上下水利用データを収集しデング熱症例のデータを収集する。また対象コホートの血清学的調査を行う。これらのデータをもとにコホート分析、地理統計解析を行い、デング熱の人口学的、環境学的リスク因子を特定し、デング熱の発生リスクをプロットしたリスクマップを作成する。そしてデング熱の蔓延の強度に応じた適切なデングワクチン戦略を提案する。

Grant-in-Aid for Challenging Research (Exploratory)

National Institute of Infectious Diseases


EUNICE KENNEDY SHRIVER CTR MTL RETARDATN


ASSESSMENT OF RENAL VIABILITY BY 31P-MRS


Behavioral Epigenetics of Developmental Methylmercury Exposure.

PUBLIC HEALTH RELEVANCE: Fetal exposure to methylmercury results in perseverative responding and deficits in choice and decision-making in adulthood, suggestive of cortical dysfunction. The fetal basis of an adult disorder suggests that methylmercury exposure may have epigenetic consequences. Adolescence is an important developmental period, both for epigenetics and for cortical development. We will examine the epigenetic basis of fetal and adolescent methylmercury exposure and the possibility that environmental enrichment or direct modification of epigenetic markers can reverse its behavioral neurotoxicity.


No summary - Aucun sommaire

Natural Sciences and Engineering Research Council of Canada


Zone tampon afin d'obtenir l'indépendance spatiale entre deux parcelles de bleuet sauvage

No summary - Aucun sommaire


COMPREHENSIVE SEQUENCE EVALUATION OF CLEFT LIP AND PALAT


IGF::OT::IGF: Phase I SBIR Contract - FY17 - Topic 363 - Connecting Cancer Caregivers to Care Teams: Digital Platforms to Support Informal Cancer Caregiving


Integrated Structural, Isotopic, and Petrologic Studies of  the Eastern Margin of the Seven Devils Terrane, West-       Central Idaho


Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort

OVERALL – PROJECT NARRATIVE The overarching goal of this research is to improve our understanding of the earliest stages at which Alzheimer’s disease develops. In this study we are examining a range of biomarkers that may help identify those who are cognitively normal but at high risk of developing cognitive decline. It is hoped that this will lead to a better understanding of the disease and to effective interventions that may prevent progression.


Preserving muscle mass and function in bedridden older adults

Older adults are at increased risk of being hospitalized or bedridden and experiencing a host of negative health outcomes including impaired insulin action, loss of lean muscle and bone mass and strength and increased morbidity and mortality. Unfortunately, current treatment options often fail when confronted with the practical realities of bed rest in aging or clinical populations. Our goal is to reduce the negative consequences of physical inactivity and promote rehabilitation in aging muscle by focusing on two novel interventions - low intensity exercise and dietary supplementation.


Beyond Fashion: Ethical Innovation in Menswear and Supply Chain Transparency

In the pursuit of an innovative and conscientious approach, we are embarking on the creation of a groundbreaking collection that embodies traceability and regeneration, from farm to garment, within the confines of just two countries. Our steadfast commitment to ethical practices and sustainability is unwavering, exclusively engaged with UK manufacturers to bring this vision to life. Through championing local production and utilising sustainable materials, redefining industry standards and changing the business model.

This endeavor not only underscores our dedication to ethical fashion but also serves as a testament to our belief in the power of collaboration. Teaming up with the esteemed French street artist, Nerone, who resides in the UK, marks a significant milestone as he lends his talent to our cause for the first time. Together, we strive to amplify a positive message and provide support to bereaved children, young people, and their families.

Our project symbolises a fusion of fashion, art, and culture. Standing as a beacon for the resurgence of British manufacturing and the creative industries, aligning seamlessly with global movements toward transparency and ethical consumerism. This venture is not just about clothing; it's about pioneering a transformative shift towards a more sustainable, regenerative and compassionate future.


USING COMPUTERS TO IDENTIFY NURSING RESOURCE USE