that mononuclear cells are involved in intussusceptive microvascular growth and that they are likely of bone marrow origin.Our preliminary data obtained from human cancer patients treated with VEGF inhibitors indicate that the switch from sprouting to IA could represent an escape mechanism also in humans accounting for the development of resistance to antiangiogenic treatment. Another important finding is In the last period we demonstrated that IA permits a rapid expansion of the capillary plexus and plays an essential role in the vascular remodeling and angioadaptation during normal and pathological angiogenesis. Our recently obtained data indicate that, during normal development and in the regenerative stages of nephritis and after partial liver resection, IA is essential for formation and restoration of an organ-specific angioarchitecture. In addition, IA plays an import role as a “escape” mechanism during and after irradiation and anti-VEGF therapy. short history, and we are only now beginning to understand its significance. Intussusceptive angiogenesis has a
novel insights in the regulation mechanisms of IA and translate the findings to clinically relevant topics as tissue regeneration and tumor growth. During the next 3 years we will focus on the following fundamental aspects: i) Blood flow and shear stress as regulatory mechanisms of IA. ii) Genetic predetermination of IA, especially the role of Notch pathway and associated with it EphrinB2/EphB4, α-SMA and Tie-2 signaling. iii) The role of the bone marrow derived stem cells in the IA during tissue regeneration and their contribution to the “escape” mechanism after anti VEGF therapy and irradiation in cancer. is to obtainThe aim of the current project
e repair, and in tumor angiogenesis. Our data will help us to design more effective pro- and anti-angiogenic treatment strategies.We anticipate that this project will yield important information relating to the role of intussusceptive angiogenesis in the embryonic development, in tissu
", "funder_award_id": "135740", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 415000.0, "currency": "CHF", "funding_type": "research", "funder_scheme": "Project funding", "start_date": "2011-12-01", "end_date": "2015-11-30", "start_year": 2011, "end_year": 2015, "landing_page_url": "https://data.snf.ch/grants/grant/135740", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Djonov,", "family_name": "Valentin", "orcid": null, "role_start": null, "affiliation": {"name": "University of Berne – BE", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087320753", "display_name": "CRCES-2020-1", "description": null, "funder_award_id": "82313", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 11000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Research Chairs - EDI Stipend", "start_date": "2020-04-01", "end_date": null, "start_year": 2020, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Campbell, Angela", "orcid": null, "role_start": null, "affiliation": {"name": "McGill University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087321091", "display_name": "Annual plan for the implementation of the resources of institutional technical reserve for the renewal of research infrastructure of the School of Public Health - USP, 2016", "description": "The Faculty of Public Health, University of São Paulo discussed the implementation of RTI FAPESP 2016 in its various instances. Three departments and the information technology section, this board linked to the FSP, presented their proposals for discussion by members of the Unit of Research Commission which prepared a single plan for the implementation of resources. The plan was submitted to the Congregation for the examination by Mr. members of the Board. Four proposals were approved. The first was presented by Section of Information Technology by the Director of FSP-USP. This was considered a priority, as it will meet students, professors and staff servers in its entirety. The second proposal was presented by the head of the Department of Epidemiology and approved, as will favor the modernization of physical infrastructure occupied by faculty, graduate students and postdocs department. The third proposal was submitted by the head of the Department of Maternal and Child was adopted. The amount requested is small, but the equipment. air conditioning, which will be installed in both enclosures are necessary since they become the most suitable and healthy environments, especially during periods of higher temperature, which undoubtedly is compounded by the use of electronic equipment that generates heat. The fourth proposal was presented by the head of the Department of Nutrition and is part of the renewal plan of laboratories that department. This will be the final stage, as two other proposals for the renewal of these laboratories were provided with RTI resources in previous years. (AU)", "funder_award_id": "16/15898-0", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "infrastructure", "funder_scheme": "Auxílio à Pesquisa - Reserva Técnica para Infraestrutura Institucional de Pesquisa", "start_date": "2016-09-01", "end_date": "2017-02-28", "start_year": 2016, "end_year": 2017, "landing_page_url": "https://bv.fapesp.br/en/auxilios/16-15898-0/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Maria", "family_name": "Anice Mureb Sallum", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408732190", "display_name": "Nasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in Infants", "description": "PROJECT NARRATIVE This Mentored Patient-Oriented Research Career Development Award will support didactic and practical training activities in bioinformatics and computational biology for Dr. Matthew Kelly, as well as research to understand how naturally occurring bacteria in the upper respiratory tract impact the risk of colonization and invasion by bacteria that cause pneumonia in children. Findings from this clinical study, involving mother-infant pairs in Botswana, may provide a basis for the development of rationally-designed probiotics that can prevent pneumonia and other respiratory infections.", "funder_award_id": "5k23ai135090-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 184181.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2018-05-23", "end_date": "2023-04-30", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/9701911", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MATTHEW SCOTT", "family_name": "KELLY", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087324030", "display_name": "Cellular Biology Of Host/parasite Interactions", "description": null, "funder_award_id": "1ziaai000567-33", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 906801.0, "currency": "USD", "funding_type": "intramural", "funder_scheme": "ZIA", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/10927741", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "TED", "family_name": "HACKSTADT", "orcid": null, "role_start": null, "affiliation": {"name": "NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES", "country": null, "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087324856", "display_name": "Neoropeptide Basis of Social Loss and Depression", "description": null, "funder_award_id": "5r01mh077776-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 402832.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-04-18", "end_date": "2013-02-28", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7615472", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "LARRY J", "family_name": "YOUNG", "orcid": null, "role_start": null, "affiliation": {"name": "EMORY UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087325019", "display_name": "NORPLANT EFFECT ON CARDIOVASCULAR RISK IN YOUNG WOMEN", "description": null, "funder_award_id": "3r01hd029478-02s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-05-01", "end_date": "1998-04-30", "start_year": 1994, "end_year": 1998, "landing_page_url": "https://reporter.nih.gov/project-details/2201906", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KAREN C", "family_name": "JOHNSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TENNESSEE HEALTH SCI CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087326540", "display_name": "Sugar Salem School/Community Library - to expand public access to computers and the Internet", "description": "to expand public access to computers and the Internet", "funder_award_id": "OPP8192", "funder": {"id": "https://openalex.org/F4320306137", "display_name": "Bill and Melinda Gates Foundation", "doi": "10.13039/100000865"}, "amount": 16263.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Global Development", "start_date": "2000-06-01", "end_date": "2000-09-30", "start_year": 2000, "end_year": 2000, "landing_page_url": "https://www.gatesfoundation.org/about/committed-grants?q=OPP8192", "doi": null, "provenance": "gates_foundation", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "Sugar Salem School/Community Library", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087330047", "display_name": "Omics, mice, and men: Development of precision transfusion medicine", "description": "In this study we test a novel hypothesis that inherited variability in genes of red blood cell proteins significantly modulate RBC function and recovery after transfusion. We will explore how donor genotype determines the time limits of blood storage and recovery of cells after storage, to identify super donors versus fragile donors.", "funder_award_id": "2r01hl098032-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 788194.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-09-18", "end_date": "2022-06-30", "start_year": 2009, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9576760", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARK T", "family_name": "GLADWIN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087330591", "display_name": "GENOMIC ANALYSIS OF INHERITED BREAST AND OVARIAN CANCER", "description": "PUBLIC HEALTH RELEVANCE: The goal of this project is characterize the whole genomes from severely affected breast and ovarian cancer families to identify new clinically actionable mutations so that they can be incorporated into clinical care. DNA and RNA samples from women with breast and ovarian cancer and their tumors will be sequenced. Mutations will be evaluated with respect to function and relative risk of breast and ovarian cancer. ", "funder_award_id": "1r35ca197458-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 927000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R35", "start_date": "2015-08-10", "end_date": "2022-07-31", "start_year": 2015, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/8955511", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY-CLAIRE", "family_name": "KING", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WASHINGTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087331166", "display_name": "Glucocorticoids & adipocyte function in human obesity", "description": "PUBLIC HEALTH RELEVANCE: Obesity increases risk for many chronic diseases, including type 2 diabetes, and thus is a major public health problem. People who store more fat inside the abdomen are at greater risk for obesity-related diseases. This proposal will lead to a deeper understanding of how fat distribution is controlled. ", "funder_award_id": "2r01dk080448-06a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 383994.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-06-01", "end_date": "2019-03-31", "start_year": 2009, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8913853", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SUSAN K", "family_name": "FRIED", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087331477", "display_name": "The Safety and Impact of Expanded Access to Naloxone in Health Systems", "description": "PROJECT NARRATIVE Opioid overdoses have reached epidemic proportions in the United States. Our study will examine the impact and safety of expanded access to naloxone, an effective opioid antidote which reverses opioid overdose, for patients prescribed opioids for pain in two large and diverse health systems. This research will address key evidence needs about expanded access to naloxone to HIV and other primary care practices.", "funder_award_id": "3r01da042059-04s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 122232.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2016-08-01", "end_date": "2021-04-30", "start_year": 2016, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9920806", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "INGRID A", "family_name": "BINSWANGER", "orcid": null, "role_start": null, "affiliation": {"name": "KAISER FOUNDATION RESEARCH INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408733174", "display_name": "レーザーコンプトン散乱の精密測定による加速電子偏極度測定法の開発", "description": "Principal Investigator：鈴木 史郎, Project Period (FY)：1978, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：核・宇宙線・素粒子", "funder_award_id": "354059", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2000000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": "1978-04-01", "end_date": "1978-03-31", "start_year": 1978, "end_year": 1978, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X00090----354059/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087332357", "display_name": "Bioengineering Approach for Advancing Reparative Medicine Stem Cell Technologies", "description": "Project Narrative Adipose derived stromal vascular fraction (SVF) transplantation is a promising new therapy for applications spanning from cardiac ischemia to tissue repair based on the idea that SVF can form new vessels. This proposed work will develop a new technology that enables the discovery of SVF dynamics in a real perfused microvascular network environment. Understanding where and how SVF cells contribute to microvascular growth will help guide their therapeutic use.", "funder_award_id": "5r21hl159501-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 181780.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2022-08-01", "end_date": "2025-07-31", "start_year": 2022, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10673032", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WALTER L", "family_name": "MURFEE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF FLORIDA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087333744", "display_name": "Was ist der Einfluss stellarer Konvektion auf die Detektierbarkeit kleiner Planeten mit der Radialgeschwindigkeitsmethode?", "description": "Eine wesentliche Richtung der Forschung im Bereich extrasolarer Planeten ist die Suche nach kleineren und leichteren Planeten. Diese Suche wird derzeit mit neuen und geplanten Instrumenten massiv vorangetrieben. Bei der Genauigkeit, die mit diesen Instrumenten und der Radialgeschwindigkeitsmethode erreicht werden kann, spielen konvektive Prozesse (jitter), deren Auswirkung im Bereich m/s liegt, eine entscheidende Rolle. In diesem Projekt wird ein entscheidender Schritt gemacht zum Verständnis des Einflusses konvektiver Prozesse auf die Messung von Radialgeschwindigkeiten, insbesondere wie dadurch die Detektierbarkeit extrasolarer Planeten beeinflusst wird, und wie dieser Mechanismus bei der Suche nach immer leichteren Planeten berücksichtigt werden kann. Die Ergebnisse dieser Arbeit liefern grundlegende Erkenntnisse zur Maximierung des wissenschaftlichen Nutzens laufender und zukünftiger Radialgeschwindigkeitsprogramme zur Suche nach extrasolaren Planeten.", "funder_award_id": "362583642", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 1099416.6538000002, "currency": "EUR", "funding_type": "research", "funder_scheme": "Schwerpunktprogramme", "start_date": "2017-01-01", "end_date": "2022-12-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/362583642", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087334072", "display_name": "PROSTATE CANCER SCREENING PROGRAM FOR AFRICAN AMERICAN M", "description": null, "funder_award_id": "5k01nr000147-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 90999.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K01", "start_date": "1999-09-30", "end_date": "2003-08-31", "start_year": 1999, "end_year": 2003, "landing_page_url": "https://reporter.nih.gov/project-details/6392977", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "VERONICA A", "family_name": "CLARKE-TASKER", "orcid": null, "role_start": null, "affiliation": {"name": "HOWARD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087334219", "display_name": "STUDIES OF CHEMICAL DISPOSITION IN MAMMALS", "description": null, "funder_award_id": "n01es065137-005", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "1986-06-30", "end_date": "1991-06-29", "start_year": 1986, "end_year": 1991, "landing_page_url": "https://reporter.nih.gov/project-details/2310383", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "A R", "family_name": "JEFFCOAT", "orcid": null, "role_start": null, "affiliation": {"name": "RESEARCH TRIANGLE INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087334607", "display_name": "Wirkungen tiefer Hirnstimulation auf Sprech und Sprachfunktionen", "description": "Während die tiefe Hirnstimulation (THS) die Primärsymptome verschiedener Bewegungsstörungen positiv beeinflusst, wurden heterogene und somit weniger kalkulierbare Veränderungen von Sprech-und Sprachleistungen unter dieser Therapie beobachtet. Diesem Problem nähert sich das folgende Projekt auf unterschiedlichen Ebenen. Aufbauend auf Vorarbeiten der Antragsteller soll mit neurophysiologischen, psychometrischen und behavioralen Methoden untersucht werden, ob und welche Funktionen THS-Zielregionen in der Verarbeitung von Sprache haben. In Kooperation mit den Projekten 3, 8 und 9 des Gesamtantrags sollen dadurch einerseits klinisches Optimierungspotenzial der Methode identifiziert bzw. perspektivisch ausgeschöpft werden und andererseits neuroanatomische und funktionelle Modelle kortiko-basaler Sprachverarbeitung fortentwickelt werden.", "funder_award_id": "180323609", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 879533.3230000001, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Klinische Forschungsgruppen", "start_date": "2010-01-01", "end_date": "2018-12-31", "start_year": 2010, "end_year": 2018, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/180323609", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087336020", "display_name": "Modélisation multi-échelle du comportement différé des géomatériaux anisotropes", "description": "This proposal is devoted to experimental investigation and numerical modelling of time dependent behaviour of geomaterials, in particular anisotropic rocks materials. The initial anisotropy of such materials is generally related to the presence of initial defeats such as bedding planes, fractures and cracks. During ulterior loading, the initial defeats can evolve and new micro-cracks can develop and grow, leading to microstructure change of materials. These microstructure evolutions can modify the anisotropic nature and significantly affect macroscopic properties of materials. It is then necessary to develop suitable modelling in order to account for microstructure evolution and interaction between initial and induced anisotropies. Moreover, the microstructure evolution is also origin of time dependent behaviour of material. In classical investigations, the time dependent behaviour is generally described by viscoplasticity theory; this approach provides an efficient mathematical tool to deal with time dependent deformation, but can not properly take into account physical origins involved. Indeed, in a number of cases, the viscosity is not the unique origin of time dependent deformation; other important phenomena can exist, such as sub-critical propagation of microcracks with stress corrosion, dissolution of inter-granular contact areas by pressure solution process. In the present project, it is proposed to deal with two complementary features: laboratory testing and in situ investigation in order to identify different phenomena which are origin of time dependent deformation; and develop a multi-scale approach for numerical modelling by including the identified mechanisms. Two representative rocks, sedimentary rock and poly-crystal rock, will be selected in this work. The present proposal will deal with three jointed features: experimental characterization of different mechanisms responsible to time dependent behaviour and determination of overall creep deformation in laboratory and in situ; development of multi-scale and multi-physics approach for numerical modelling; numerical implementation, validation and application. These features will be organized in 8 tasks, which are described in detail in the research program: ? Task 1: experimental characterisation of phenomena; ? Task 2: experimental investigation of chemomechanical coupling; ? Task 3: characterization of overall time dependent deformation; ? Task 4: in situ experimental in situ; ? Task 5: formulation of a basic constitutive model for instantaneous mechanical behaviour of rocks ? Task 6: extension of the basic model to time-dependent behaviour; ? Task 7: consideration of chemomechanical coupling; ? Task 8: numerical implementation and validation.", "funder_award_id": "ANR-09-BLAN-0380", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 201344.0, "currency": "EUR", "funding_type": "research", "funder_scheme": "Blanc", "start_date": "2010-03-01", "end_date": null, "start_year": 2010, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-09-BLAN-0380", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Jianfu", "family_name": "SHAO", "orcid": null, "role_start": null, "affiliation": {"name": "CNRS DR NORD PAS DE CALAIS PICARDIE", "country": "France", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087336439", "display_name": "The genetics of bacterial evolution and biodiversity", "description": "The aim of the project is to significantly advance and deepen knowledge of the mechanisms driving evolution and biodiversity in the bacterial kingdom. Bacterial evolutionary change is traditionally explained by the combined effects of mutation and horizontal gene transfer events. However, analysis of the ongoing flood of bacterial genomic data has revealed at least two features of bacterial chromosomes that appear to be discordant with the standard model of genetic change. These are, the recent discoveries of bacterial strains with hybrid chromosomes, and the prevalence of chromosomal gene order rearrangements between bacterial species, neither of which is easily explained by the traditional model. By combining experimental and in silico approaches the project will explore hypotheses to explain the mechanisms driving these changes, their relevance in clinical and natural isolates, and the genetic and environmental features that influence the rates of change associated with these mechanisms. The outcomes will influence our understanding in several important areas, including evolution of virulence and antibiotic resistant pathogens, and the processes of lineage separation and speciation in bacteria. This project concept is highly original and could fundamentally expand our understanding of mechanisms and rates of bacterial evolution.", "funder_award_id": "2021-04814_VR", "funder": {"id": "https://openalex.org/F4320322581", "display_name": "Vetenskapsrådet", "doi": "10.13039/501100004359"}, "amount": 4070000.0, "currency": "SEK", "funding_type": "research", "funder_scheme": "Project grant", "start_date": "2022-01-01", "end_date": "2025-12-31", "start_year": 2022, "end_year": 2025, "landing_page_url": "https://www.vr.se/swecris#/project/2021-04814_VR", "doi": null, "provenance": "swedish_research_council", "lead_investigator": {"given_name": "Diarmaid", "family_name": "Hughes", "orcid": "0000-0002-7456-9182", "role_start": null, "affiliation": {"name": "Uppsala University", "country": "Sweden", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087337234", "display_name": "GEMS, a Short-Term Summer Internship Program for Diverse Students", "description": "This short-term internship program at the University of Colorado Anschutz Medical Campus, locally known as GEMS (Graduate Experiences for Multicultural Students) seeks to expose undergraduate and health professional students from backgrounds under-represented in research to summer laboratory or clinical translational experiences in order to increase their representation in research related to cardiovascular, pulmonary or hematologic areas. The goal is to create a workforce of health-related researchers who are as diverse as the community they serve. By exposing these students early in their careers, we hope to capture their interest and excite them about the possibilities of biomedical research.", "funder_award_id": "2r25hl103286-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 128520.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R25", "start_date": "2010-07-01", "end_date": "2025-06-30", "start_year": 2010, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10023417", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ADELA", "family_name": "COTA-GOMEZ", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO DENVER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408734087", "display_name": "EVALUATION OF POLICY-RELATED RESEARCH IN THE FIELD OF MUNICIPAL SYSTEMS, OPERATIONS, AND SERVICES-FRANCHISING AND REGULATION", "description": null, "funder_award_id": "7358872", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1973-01-01", "end_date": "1974-01-01", "start_year": 1973, "end_year": 1974, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7358872", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087341647", "display_name": "INNATE IMMUNE RESPONSES TO MALARIA PARASITE", "description": null, "funder_award_id": "5r01ai041139-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 357984.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-01-15", "end_date": "2012-05-31", "start_year": 1998, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7433323", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHANNE D", "family_name": "GOWDA", "orcid": null, "role_start": null, "affiliation": {"name": "PENNSYLVANIA STATE UNIV HERSHEY MED CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087344387", "display_name": "Understanding the origin,initiation,and progression of high-grade serous ovarian", "description": "PUBLIC HEALTH RELEVANCE: Currently no diagnostic test or screening can detect ovarian cancer early enough to reduce the mortality. The lack of effective early detection is primarily because the early tumor biology of deadly ovarian cancer has been largely unknown. The proposed research will help improve our understanding on the early tumor mechanism and progression of this deadly cancer, which will offer valuable insights for developing effective earl detection and targeted therapy.", "funder_award_id": "5k99ca179137-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 95826.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K99", "start_date": "2013-09-24", "end_date": "2016-01-31", "start_year": 2013, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8740474", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAEYEON", "family_name": "KIM", "orcid": null, "role_start": null, "affiliation": {"name": "BAYLOR COLLEGE OF MEDICINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087344671", "display_name": "Flexible and sustainable production of high performance rolling bearings", "description": "Purpose and goal:\r\nThe project aims to increase the production flexibility for the manufacturing of large sized bearings by reducing the number of process steps and improving the properties of the components by using a novel hard turning (HaT) strategy. This will be realised by develop and potentially develop a methodology to qualify the hard-turning process as a finishing process. This strategy will generate a unique high-strength metallic surface, which will improve the surface mechanical properties hence the life of the bearings.\r\n\r\nExpected results and effects:\r\nThe project aims to improve the manufacturing of bearings which will both enable prolonged life of the bearings as such but also allows for reducing the manufacturing leadtime, the energy consumption and enable mass customization enabled by the HaT process.\r\n\r\nApproach and implementation:\r\nTURN2FLEX will be operating in three major phases; Phase 1 involves carrying out the machining tests at Sumitomo in Germany to set the machining conditions. In Phase 2, the tests performed in Phase 1 will be validated at the research centre at SKF. In Phase 3, the machining tests will be carried out in a machining centre resembling similar condition as the production to evaluate the process robustness. All the characterization of the produced parts will be performed by Chalmers and RISE. The mechanical tests will support to reach the set goal with respect to surface integrity properties.", "funder_award_id": "2021-01274_Vinnova", "funder": {"id": "https://openalex.org/F4320321030", "display_name": "VINNOVA", "doi": "10.13039/501100001858"}, "amount": 4625000.0, "currency": "SEK", "funding_type": "grant", "funder_scheme": "Project grant", "start_date": "2021-04-28", "end_date": "2024-10-21", "start_year": 2021, "end_year": 2024, "landing_page_url": "https://www.vr.se/english/swecris.html", "doi": null, "provenance": "swecris_vinnova", "lead_investigator": {"given_name": null, "family_name": "Jonas Holmberg", "orcid": null, "role_start": "2021-04-28", "affiliation": {"name": "RISE Research Institutes of Sweden", "country": "Sweden", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087346366", "display_name": "Integrated Antimicrobial Drug Discovery Scheme for Multidrug Resistant Bacteria", "description": null, "funder_award_id": "1u01ai070499-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 753442.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2006-07-15", "end_date": "2011-06-30", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7134709", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ZOLTAN N.", "family_name": "OLTVAI", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087348399", "display_name": "Producing experts, practicing expertise: an ethnographic study of lactation consultation", "description": null, "funder_award_id": "21120", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 23600.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Doctoral Fellowships", "start_date": "2000-04-01", "end_date": null, "start_year": 2000, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Currie, Gail", "orcid": null, "role_start": null, "affiliation": {"name": "University of Toronto", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408734976", "display_name": "Modeling perception in visual cortex", "description": "No summary - Aucun sommaire", "funder_award_id": "381688-2009", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4500.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "University Undergraduate Student Research Awards", "start_date": "2009-04-01", "end_date": "2010-03-31", "start_year": 2009, "end_year": 2009, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=381688-2009", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Antoine", "family_name": "RhéaumeOuellet", "orcid": null, "role_start": null, "affiliation": {"name": "Université Laval", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087350086", "display_name": "Research for development of therapy of Machado-Joseph disease by siRNA", "description": "Machado-Joseph disease is a progressive heredodegenerative disease that is caused by unstable expansions of CAG repeats in MJD which is located at chromosome 14q32.1. The mutant ataxin-3, the gene product of MJD, carrying the expanded polyglutamine stretch gains an adverse function and causes dysfunction of neurons, leading to neuronal death. No effective therapeutics has been established. If the expression of the mutant protein could be inhibited, we could treat the disease very well. Short interfering RNA (siRNA) would be a good candidate to establish an effective therapeutics.Huntington's disease is also one of the polyglutamine diseases and cased by an abnormally expanded CAG repeats in exon 1 of the HD gene. It was investigated that the effects of siRNAs directed against the HD gene in order to knock down its expression in cultured cells. One siRNA, named as siRNA-HD-Exon1, which is targeted against the region at immediate upstream of the CAG repeats, can efficiently and specifically inhibit the expression of HD exon 1-EGFP fusion mini-gene. It also did efficiently suppress the endogenous huntingtin expression in cultured cell lines derived from human neuroblastoma (Proc Japan Acad 79(Ser B) : 293-298, 2003).There are several single nucleotide polymorphisms (SNPs) in the MJD gene. In Japanese population, there are two haplotypes of those SNPs. One is c527T-c669A-c987C-c1118A and the other is c527C-c669G-c987G-c1118C.Disease chromosomes which carry the abnormally expanded CAG repeats show exclusively the former haplotype. If the expression of the allele carrying that haplotype could be specifically and effectively inhibited by a suitable siRNA, it would be the first step toward the development of a radical therapy for MJD. Two research groups reported successful suppression of the haplotype-specific expression by the siRNA of which the target is the sequence surrounding c987C/G SNP.", "funder_award_id": "15590880", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3500000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590880/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Jun", "family_name": "GOTO", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Tokyo", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010211252", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087350886", "display_name": "Geriatric Oncology: Cognition and Communication", "description": "Project Narrative This cancer education training project’s goal is to train healthcare providers (HCPs) to work more effectively with older cancer patients who may have cognitive and functional difficulties. This project is important because it will help prepare the work force to care for the growing numbers of older cancer patients and their families. Results of this study have the potential to improve the knowledge and communication skills of oncology HCPs which will benefit HCPs and older oncology patients and their families.", "funder_award_id": "5r25ca236579-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 198053.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R25", "start_date": "2019-09-19", "end_date": "2024-11-30", "start_year": 2019, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10745314", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PATRICIA A", "family_name": "PARKER", "orcid": null, "role_start": null, "affiliation": {"name": "SLOAN-KETTERING INST CAN RESEARCH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087351591", "display_name": "STRUCTURAL PROPERTIES OF GROUP 1, 11, AND 111 ORGANOMETALLIC COMPOUNDS", "description": null, "funder_award_id": "7354567", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1973-01-01", "end_date": "1974-01-01", "start_year": 1973, "end_year": 1974, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7354567", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087351897", "display_name": "Collaboration internationale en Chimie : origines des anomalies thermodynamiques et dynamiques de l'eau liquide métastable", "description": "Water is among the most important and most studied substances on earth, yet, the origins of its anomalous thermodynamic, dynamic, and structural properties have eluded complete understanding. Theoretical, computational, and experimental work suggests that clues to these origins lie in the metastable states of water at negative pressures (stretched superheated regime) and at supercooled temperatures. This collaborative proposal brings a broad, new set of techniques to bear on the challenge of providing a complete, experimental analysis of these states. The outcomes of this project will build the foundation of improved understanding of water and will provide a rich training ground for students in experimental physical chemistry. Outstanding questions: Q1) Phase diagram and structure in the stretched superheated and supercooled regimes. The equation of state has never been mapped deep into these regimes, leaving open fundamental questions about features that could explain the anomalous properties of water. Computational studies indicate a tight correlation between the evolution of molecular structure and macroscopic anomalies. The minimal experimental data on structure in the streched superheated regime leave open important questions regarding the accuracy of these predictions and the energetics (enthalpy vs. entropy) that may dictate these phenomena. Q2) Mechanisms of failure of metastable states. In all but one experiment, the observed stability limit in the stretched superheated regime has been several fold lower than predicted theoretically. Recent experiments by Caupin suggest that there may exist a fundamental mechanism of nucleation that is not accounted for in conventional predictions; the elucidation of this mechanism would have profound scientific and technological implications. Q3) Viscosity in the supercooled regime. Only one reliable experiment is available at 1 bar in the supercooled regime; none exist in the streched superheated regime. These measurements, combined with existing diffusivity data, will allow to check the Stokes-Einstein and Stokes-Einstein-Debye relations, thought to be violated in water at higher temperatures than usual glass forming liquids and to provide a signature of the liquid-liquid critical point predicted by simulations in the supercooled region.", "funder_award_id": "ANR-09-BLAN-0404", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 700391.0, "currency": "EUR", "funding_type": "research", "funder_scheme": "Blanc", "start_date": "2010-03-01", "end_date": null, "start_year": 2010, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-09-BLAN-0404", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Frédéric", "family_name": "CAUPIN", "orcid": null, "role_start": null, "affiliation": {"name": "CNRS DELEGATION REGIONALE PARIS B", "country": "France", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087352056", "display_name": "A murine model to investigate the mechanisms underlying DOHaD", "description": "Recent studies have clearly established a relationship between sub-optimal intrauterine and post-natal development, and later life predisposition to adult disease, including type II diabetes, hypertension, heart disease, stroke and other neurologic disorders a relationship termed \"developmental origins of health and disease\" (DOHaD). While adverse pre- and postnatal development increases the risk of DOHaD it does not determine that an individual will acquire these disorders suggesting that interactions between an individuals genotype and the environment may contribute to the eventual outcome. Increasing evidence suggests that premature activation of the fetal hypothalamic-pituitary-adrenal (HPA) axis is a central component linking adverse pre and/or post-natal environmental exposures to later poor health outcomes. We have developed a novel mouse model in which dietary restriction of the mothers during pregnancy leads to symptoms of DOHaD disorders in the offspring. We will use this model to define gene-environment interactions that result in DOHaD disorders. We anticipate that this study will enhance progress towards future intervention strategies aimed at reducing the burden of these disorders.", "funder_award_id": "81238_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 373673.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Operating Grant", "start_date": "2006-10-01", "end_date": "2009-09-30", "start_year": 2006, "end_year": 2009, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Stephen", "family_name": "Lye", "orcid": null, "role_start": "2006-10-01", "affiliation": {"name": "Lunenfeld-Tanenbaum Research Institute (Toronto)", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087352531", "display_name": "Improving Health Care for Women Veterans: Addressing Menopause and Mental Health", "description": "Advancing comprehensive care for women Veterans is a VA priority, as the number of women Veterans served by the VA has doubled in the past decade and continues to grow rapidly. However, providing gender-sensitive care in this setting is a recognized challenge. Women Veterans have complex care needs, complicated by reproductive health concerns and a high rate of mental health diagnoses. Menopausal symptoms common in this period may contribute to mental health concerns in addition to poor quality of life, health risk behaviors, and chronic health conditions. An estimated half of women Veterans VA users may currently be affected, but little is known about the experience of menopause among women Veterans, or current practices and preferences for menopause-related care among patients and providers in the VA setting. Innovative efforts to increase access to gender-sensitive menopause-related care for women Veterans may provide an opportunity to improve whole health for this population, and healthy aging in the years that follow.", "funder_award_id": "5ik2hx002402-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "IK2", "start_date": "2018-06-01", "end_date": "2023-05-31", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10186536", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CAROLYN", "family_name": "GIBSON", "orcid": null, "role_start": null, "affiliation": {"name": "VETERANS AFFAIRS MED CTR SAN FRANCISCO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087354415", "display_name": "STRUCTURAL AND FUNCTIONAL BASIS OF THE VITAMIN K CYCLE", "description": " PROJECT NARRATIVE The proposed research is relevant to public health because VKOR is the target of warfarin, the most commonly prescribed oral anticoagulant. Warfarin is used to treat and prevent thrombosis diseases including deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. Understanding the mechanism of VKOR function and warfarin inhibition will help to produce clotting factors to treat bleeding disorders and to design better anticoagulants.", "funder_award_id": "1r01hl121718-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 381094.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2014-05-15", "end_date": "2019-04-30", "start_year": 2014, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8615680", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WEIKAI", "family_name": "LI", "orcid": null, "role_start": null, "affiliation": {"name": "WASHINGTON UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087355926", "display_name": "Enhancing motor competence, health-related fitness, and psychosocial wellbeing among children with motor difficulties – A cluster-randomized controlled trial (MoDiSchool)", "description": "This study focuses on helping school-aged children with motor difficulties by improving early recognition and support. In the first phase, we will explore how these challenges can be identified using input from children (n=1200), parents (n=1200), and teachers (n=510). We will combine standardized tests, and children's, parents' and teachers' reports to assess motor difficulties and compare the results of different methods. We will also examine teachers' competencies to support motor skill development. In the second phase, we will test a 20-week physical activity intervention program. The study will involve three groups: classroom activities only, classroom and extracurricular activities, and a control group. Outcomes include physical and psycho-social variables, with follow-ups at 5 and 12 months. Teachers will co-design the program to ensure it fits well in schools. Study results can be widely used in schools and teacher education.", "funder_award_id": "370268", "funder": {"id": "https://openalex.org/F4320321108", "display_name": "Academy of Finland", "doi": "10.13039/501100002341"}, "amount": 374980.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Academy Programme for Sport Science and Physical Activity (ACTIVE) 2025 call for applications", "start_date": "2025-01-01", "end_date": "2028-08-30", "start_year": 2025, "end_year": 2028, "landing_page_url": "https://research.fi/en/results/funding/82926", "doi": null, "provenance": "researchfi", "lead_investigator": {"given_name": " ", "family_name": " ", "orcid": null, "role_start": null, "affiliation": {"name": null, "country": "Finland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087356662", "display_name": "腐蝕性根管消毒剤の生体に対する為害性に関する研究", "description": "Principal Investigator：藤正 敬夫, Project Period (FY)：1982 – 1984, Research Category：Grant-in-Aid for General Scientific Research (B), Research Field：Conservative dentistry", "funder_award_id": "57482007", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 5500000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-57482007/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087356831", "display_name": "DEFENSE & STATE MEMORANDUM OF AGREEMENT - COOPERATIVE AGREEMENT", "description": "DEFENSE & STATE MEMORANDUM OF AGREEMENT - COOPERATIVE AGREEMENT", "funder_award_id": "W912DY1620216", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 167000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "STATE MEMO OF AGREEMENT PROGRAM FOR THE REIMBURSEMENT OF TECHNICAL SERVS", "start_date": "2016-07-01", "end_date": "2018-06-30", "start_year": 2016, "end_year": 2018, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_W912DY1620216_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408735736", "display_name": "Salmonella pathogenicity island 2 effector proteins", "description": null, "funder_award_id": "5r01ai048683-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 331002.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2001-01-15", "end_date": "2011-02-28", "start_year": 2001, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7750531", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SAMUEL I", "family_name": "MILLER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WASHINGTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087357393", "display_name": "Value in People Award.", "description": "No description available", "funder_award_id": "360G-Wellcome-084567_Z_07_Z", "funder": {"id": "https://openalex.org/F4320311904", "display_name": "Wellcome Trust", "doi": "10.13039/100010269"}, "amount": 350000.0, "currency": "GBP", "funding_type": "grant", "funder_scheme": "Value in People Awards", "start_date": "2008-10-01", "end_date": "2009-09-30", "start_year": 2008, "end_year": 2009, "landing_page_url": "https://wellcome.org/grant-funding/people-and-projects/grants-awarded?q=360G-Wellcome-084567_Z_07_Z", "doi": null, "provenance": "wellcome_trust", "lead_investigator": {"given_name": "Dr John", "family_name": "Hood", "orcid": null, "role_start": null, "affiliation": {"name": "University of Oxford", "country": "United Kingdom", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087363732", "display_name": "Lipid Aldehyde and Ethanol Induced Liver Damage", "description": null, "funder_award_id": "5r37aa009300-16", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 406791.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R37", "start_date": "1993-07-01", "end_date": "2013-05-31", "start_year": 1993, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8080466", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DENNIS", "family_name": "PETERSEN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO DENVER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087364286", "display_name": "Role of Heparan Sulfate in FGF Action", "description": null, "funder_award_id": "5r01gm048850-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 263445.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1993-01-01", "end_date": "2006-03-31", "start_year": 1993, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6620949", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ALAN C", "family_name": "RAPRAEGER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WISCONSIN MADISON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087364325", "display_name": "The study to reveal the neuroprotective mechanisms induced by electrical stimulation of the brain", "description": "We tried to reveal the neuroprotective mechanisms induced by the electrical stimulation of cerebellar fastigial nucleus (FN) in rats. 1h-FN stimulation decreased, 72h later, the infarct volume by 22%. 1h-FN stimulation increased, 72h later, mRNA level of uncoupling protein 4 (UCP4), a mitochondria protein, to 160% in the brain. Intra-ventricular injection of siRNA decreased the UCP4 mRNA level, and tended to abolish the neuroprotection induced by FN stimulation. Following FN stimulation, up-regulation of UCP4 may be a component of the endogenous neuroprotective mechanisms.", "funder_award_id": "20390380", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 18070000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20390380/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Seiji", "family_name": "YAMAMOTO", "orcid": null, "role_start": null, "affiliation": {"name": "Hamamatsu University School of Medicine", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000060144094", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087364636", "display_name": "Paracrine and synaptic mechanisms underlying recovery using human stem cell thera", "description": "PUBLIC HEALTH RELEVANCE: Stem cells therapy offers hope to the millions of stroke patients in the US who live with its debilitative effects. With its devastating long-term consequences to patients and their families, and the tremendous societal costs in the billions of dollars each year, the implications of a successful treatment for stroke are enormous. Because stem cells target brain repair and thus can have a therapeutic effect months or even years post-injury, their use as a stroke treatment has the potential to impact a vastly larger proportion of te patient population than current therapeutic strategies.", "funder_award_id": "5r01ns058784-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 446009.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-08-01", "end_date": "2016-07-31", "start_year": 2008, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8889309", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GARY K", "family_name": "STEINBERG", "orcid": null, "role_start": null, "affiliation": {"name": "STANFORD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087373249", "display_name": "Proposed Meeting Series: The Message Passing Interface Forum", "description": "The work of the proposed Message Passing Interface Forum addresses the continuation of activity focused on enhancing the Message Passing Interface (MPI) for passing data between processors in distributed computing systems built from heterogeneous multi-cores, for parallel remote file operations, and for dynamic process control of such parallel applications. The current standard provides a core of routines used for point-to-point and one-sided data exchange, blocking collective communications routines, remote parallel file access and dynamic process control. In addition, these are augmented with support for features such as derived data types, communications contexts, process groups, and virtual process topologies. \r\nThe work of this forum will produce a communications standard suitable for addressing the needs of parallel applications on the next generation computing facilities at the petascale level and beyond.", "funder_award_id": "1144042", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 70272.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2011-08-01", "end_date": "2012-12-31", "start_year": 2011, "end_year": 2012, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1144042", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Jack", "family_name": "Dongarra", "orcid": null, "role_start": null, "affiliation": {"name": "University of Tennessee Knoxville", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087373708", "display_name": "Defining the Role of ERG in Modulating the AR Cistrome and Antiandrogen Sensitivity", "description": "PUBLIC HEALTH RELEVANCE: Over half of prostate cancer cases are caused by chromosome translocations that result in aberrant expression of the ERG transcription factor. This project will shed light on the molecular mechanisms by which ERG causes prostate cancer and the impact of ERG on response to therapies directed against the androgen receptor, the common form of treatment for metastatic prostate cancer.", "funder_award_id": "5r01ca193837-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 462551.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2015-04-01", "end_date": "2021-01-31", "start_year": 2015, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9660543", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHARLES L.", "family_name": "SAWYERS", "orcid": null, "role_start": null, "affiliation": {"name": "SLOAN-KETTERING INST CAN RESEARCH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408737489", "display_name": "Mechanisms Regulating Megakaryocyte Development", "description": "Megakaryocytes (MKs) are responsible for the production of platelets, which have a major impact on blood homeostasis. MKs is unique among blood cells in attaining states of polyploidy, which precedes platelet biogenesis. Uncontrolled MK proliferation and deregulated polyploidization are hallmarks of blood cells pathology, and this research proposal focuses on novel aspects of regulation of MK expansion and polyploidization, involving Lysyl Oxidase (LOX) as a newly identified regulator of these processes.", "funder_award_id": "5r01hl080442-09", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 403111.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2006-04-01", "end_date": "2017-09-30", "start_year": 2006, "end_year": 2017, "landing_page_url": "https://reporter.nih.gov/project-details/8823809", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KATYA", "family_name": "RAVID", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087377290", "display_name": "Bariatric Surgery's Return on Investment for Veterans and VHA", "description": "The proposed study examines weight change after bariatric surgery, the resolution of diabetes, hypertension, and hyperlipidemia, and the durability of weight change and disease resolution by follow patients over an entire decade of care (2000-2012). The long-term durability of these health improvements have been poorly characterized in the literature. We will also identify patient-level characteristics that are associated with failures - failures to lose weight, failures to resolve comorbidities, and failures to achieve long-term weight maintenance - in an explicit attempt to identify important factors associated with less desirable health and economic outcomes. These new areas of inquiry will address important limitations of our initial work and the existing bariatric surgery literature.", "funder_award_id": "5i01hx000420-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "I01", "start_date": "2011-09-01", "end_date": "2014-08-30", "start_year": 2011, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8597282", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MATTHEW L", "family_name": "MACIEJEWSKI", "orcid": null, "role_start": null, "affiliation": {"name": "DURHAM VA MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087378952", "display_name": "Neighborhood Effects on Health and Functioning of Elders", "description": null, "funder_award_id": "5r01ag018369-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 280582.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2001-09-01", "end_date": "2004-08-31", "start_year": 2001, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6533879", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "LISA F", "family_name": "BERKMAN", "orcid": null, "role_start": null, "affiliation": {"name": "HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087379477", "display_name": "A COMPARISON OF THREE APPROACHES TO SUPPORTED EDUCATION", "description": null, "funder_award_id": "5hd5sm047669-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "HD5", "start_date": "1992-09-30", "end_date": "1996-08-31", "start_year": 1992, "end_year": 1996, "landing_page_url": "https://reporter.nih.gov/project-details/2287818", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CAROL T", "family_name": "MOWBRAY", "orcid": null, "role_start": null, "affiliation": {"name": "MICHIGAN STATE DEPT OF COMMUNITY HEALTH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087379535", "display_name": "Midcareer Mentoring Award for Patient-Oriented Research in Aging", "description": "PUBLIC HEALTH RELEVANCE: With this K24 award, Dr. Rachel Werner will continue to develop her successful research program aimed at improving the delivery of care for older patients with complex and chronic illness, with a new focus on the implementation and evaluation of delivery system innovations using randomized trials. She will use her research as a platform to mentor new investigators in this field and help them to become independent investigators. Taken together, her ongoing and proposed research, coupled with her mentorship program to train outstanding investigators in the field, will help address the critical need to reform the health care delivery system to efficiently bring high quality care to the millions of aging Americans in need of better care. ", "funder_award_id": "1k24ag047908-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 210284.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K24", "start_date": "2014-09-15", "end_date": "2019-04-30", "start_year": 2014, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8749118", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RACHEL M", "family_name": "WERNER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087379667", "display_name": "Optics For Pre-College Science Teachers and Scientists", "description": null, "funder_award_id": "7800716", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 22600.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1978-04-01", "end_date": "1980-09-30", "start_year": 1978, "end_year": 1980, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7800716", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Edward", "family_name": "Brody", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087381539", "display_name": "RETINAL DISEASE: MOLECULAR BASIS AND PATHOPHYSIOLOGY", "description": null, "funder_award_id": "3r01ey011996-06s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 330654.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-02-01", "end_date": "2007-01-31", "start_year": 1998, "end_year": 2007, "landing_page_url": "https://reporter.nih.gov/project-details/6943315", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PATSY M", "family_name": "NISHINA", "orcid": null, "role_start": null, "affiliation": {"name": "JACKSON LABORATORY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087386079", "display_name": "Biomechanical Optimization of TE Heart Valves", "description": null, "funder_award_id": "5r01hl068816-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 427229.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2002-03-01", "end_date": "2012-12-31", "start_year": 2002, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/8035309", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM R", "family_name": "WAGNER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087386364", "display_name": "Cell physiological and molecular biological mechanisms of the function of the stria vascularis in the cochlea", "description": "Intermediate cells are melanocytes in the stria vascularis. To examine the contribution of the membrane potential of intermediate cells (E_m) to the endocochlear potential (EP), a comparison was made between the effects of K^+ channel blockers on the E_m and those on the EP. The E_m changed by 55.1 mV per ten-fold changes in extracellular K^+ concentration. Ba^<2+>, Cs^+ and quinine depressed the E_m in a dose-dependent manner, whereas tetraethylammonium at 30 mM and 4-aminopyridine at 10 mM had no effect. To examine the effect of the K^+ channel blockers on the EP, the EP of guinea pigs was maintained by vascular perfusion, and K^+ channel blockers were administered to the artificial blood. Ba^<2+>, Cs^+ and quinine depressed the EP in a dose-dependent manner, whereas tetraethylammonium at 30 mM and 4-aminopyridine at 10 mM did not change the EP. The changes in the EP were similar to those seen in the E_m On the basis of these results, we propose that : the EP is critically dependent…Moreon the voltage jump across the plasma membrane of intermediate cells.The intercellular space in the stria vascularis (intrastrial space) is a closed space and isolated from both the endolymph and the perilymph in normal tissue. Loop diuretics such as bumetanide and furosemide cause an acute enlargement of the intrastrial space in association with a decline in the endocochlear potential. It is known that bumetanide inhibits the Na^+-K^+-2Cl^- cotransporter, which is expressed abundantly in the basolateral membrane of marginal cells. We studied ionic mechanisms underlying the bumetanide-induced enlargement of the intrastrial space using perilymphatic perfusion in guinea pigs. Perilymphatic perfusion with artificial perilymph containing 100 μM bumetanide caused marked enlargement of the intrastrial space, as reported previously. Removal of K^+ from the perilymph did not affect the bumetanide-induced enlargement, whereas removal of Na^+ from the perilymph inhibited it almost completely. Perilymph containing 1 mM amiloride also inhibited the enlargement of the intrastrial space almost completely. These results indicate that perilymphatic Na^+, but not K^+, and amiloride-sensitive pathways are essential to the bumetanide-induced enlargement of the intrastrial space. Two possible pathways could yield these results. Na^+ in the perilymph could enter the endolymph via Reissner's membrane or the basilar membrane ; Na^+ in the endolymph would then be taken up by marginal cells via the apical membrane and secreted into the intrastrial space by Na^+-K^+-ATPase in the basolateral membrane of them. Another, less likely, possibility is that Na^+ in the perilymph is transported into basal cells or fibrocytes in the spiral ligament, then into intermediate cells via gap junctions, and finally secreted into the intrastrial space via Na^+-K^+-ATPase of intermediate cells.Less", "funder_award_id": "12671671", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3800000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12671671/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Shunji", "family_name": "TAKEUCHI", "orcid": null, "role_start": null, "affiliation": {"name": "Kochi Medical School", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050188158", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087386715", "display_name": "Regulation of Cellular Cholesterol Homeostasis", "description": "PUBLIC HEALTH RELEVANCE: Lipid homeostasis is essential for cell function and disruptions to lipid homeostasis lead to common diseases that are public health imperatives in the United States. Elevated serum cholesterol is a primary risk factor for heart disease, and diabetes causes fatty liver that frequently progresses to liver cirrhosis and cancer. This proposal seeks to understand the function and regulation of the SREBP transcription factors that control lipid homeostasis, thereby identifying new points for prevention and therapeutic intervention for these widespread diseases.", "funder_award_id": "5r01hl077588-14", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 404869.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2004-07-01", "end_date": "2018-12-31", "start_year": 2004, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/9245721", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PETER J.", "family_name": "ESPENSHADE", "orcid": null, "role_start": null, "affiliation": {"name": "JOHNS HOPKINS UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087386978", "display_name": null, "description": null, "funder_award_id": "65u1283", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1965-01-01", "end_date": "1965-01-01", "start_year": 1965, "end_year": 1965, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=65U1283", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087388887", "display_name": "Managing Digital Data Collections for the Earth & Ocean Sciences: Geoinformatics for Geochemistry and the Marine Geoscience Data System", "description": "Intellectual Merit: This research combines major geochemical database operations for the marine geosciences at the Lamont Doherty Earth Observatory of Columbia University into a fully integrated management system called the Geoinformatics for Geochemistry Program. The work allows the combined efforts to build on substantial synergies between the presently disparate efforts. It will enhance interoperability of the present web accessible database and allows the program to achieve both sustainability and economies of scale in terms of staffing, education and outreach, and staffing. \r\n\r\nBroader Impacts: Broader impacts of the work are to enhance the infrastructure for research in the marine geosciences and allow fundamental new understandings in the Earth and Ocean Sciences due to the ease of combining and visualizing various disparate data sets. The new management structure allows universal public and scientific access to global data compilations that support research and education in the Earth and Ocean Sciences.\r\n", "funder_award_id": "0649638", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 500210.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2007-04-15", "end_date": "2011-03-31", "start_year": 2007, "end_year": 2011, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0649638", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Kerstin", "family_name": "Lehnert", "orcid": null, "role_start": null, "affiliation": {"name": "Columbia University Lamont Doherty Earth Observatory", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087389199", "display_name": "Epidemiological features, national burden of several HPV-related diseases and estimation of cost-effectiveness of HPV vaccines in Vietnam", "description": "This project is designed to collect the evidence that will be needed to support the introduction of the cancer-preventing vaccine HPV (Human Papillomavirus) into the national immunization program of Vietnam. HPV is the second vaccine that has been developed that can prevent cancer (the first being Hepatitis B vaccine which prevents liver cancer). HPV vaccine prevents HPV infection, which is responsible for almost all cases of cancer of the cervix in women. In Western countries cancer of the cervix is much less common than in developing countries, because the regular cervical screening (Pap smears) identifies and treats very early cases. HPV is very common in developing countries like Vietnam, and the cancers that it causes are usually detected late, leading to high mortality. HPV is also responsible for a variety of other cancers affecting both men and women, including penile cancer, anal cancer and throat cancer. The vaccine is used is most industrialized countries, and is given to girls, and in some countries to boys as well. It has been introduced into very few developing countries, because of its high price, and the lack of evidence about HPV infection and disease in those countries. Vietnam is a rapidly modernizing country, with a booming economy and a population that is becoming increasingly westernized. HPV is spread by unprotected sex, and rates of infection are very high among sex workers and men who have sex with men. This project will study the rate of HPV infection among young university students in north, south and central Vietnam to get a national perspective. We will also study two important high risk groups, sex workers and men who have sex with men in both the north and south. We will use the records of the cancer hospitals in Vietnam to estimate the proportion of the population who were affected by HPV associated cancer, and to understand better the ages affected and the outcome and treatment costs of cases. This will enable us to predict the effect of HPV vaccine introduction on the community and calculate the money that will be saved by the health system if those cancers are prevented. Finally we will develop, within Vietnam, the laboratory skills that are needed to study HPV disease, and especially to undertake a trial of HPV vaccines in Vietnam. The trial is not covered by this proposal, but we hope in future to do a trial that will help us to decide which is the simplest and therefore least expensive, way to introduce HPV vaccine into a developing country like Vietnam. The project will be undertaken jointly by five institutions. The three Vietnamese institutions (two in the north and one in the south) will be able to share their expertise in this area and also develop new skills with help from expert groups in London (London School of Hygiene and Tropical Medicine) and Australia (Murdoch Childrens Research Institute).", "funder_award_id": "MR/N028473/1", "funder": {"id": "https://openalex.org/F4320334626", "display_name": "Medical Research Council", "doi": "10.13039/501100000265"}, "amount": null, "currency": "GBP", "funding_type": "research", "funder_scheme": null, "start_date": "2016-07-14", "end_date": "2021-06-29", "start_year": 2016, "end_year": 2021, "landing_page_url": "https://gtr.ukri.org/projects?ref=MR/N028473/1", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087394984", "display_name": "Food Safety & BSE/Ruminant Feed Ban Support Project", "description": " The safety of the nation's food supply is critical in the advent of recent pathogenic outbreaks and global food and feed adulteration incidents. Agricultural production systems form the base for a healthy population and a strong economy. This grant will address human and animal safety by evaluating feed products for adulterants and natural toxins that have not been scrutinized in the past with the aim of a safer food supply for the United States.", "funder_award_id": "1u18fd003997-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 250000.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U18", "start_date": "2010-09-17", "end_date": "2015-06-30", "start_year": 2010, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8115508", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "TRAVIS JAY", "family_name": "KNIGHT", "orcid": null, "role_start": null, "affiliation": {"name": "IOWA DEPT AGRICULTURE/LAND STEWARDSHIP", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40873953", "display_name": "Future day", "description": "Purpose and goal:\r\nThe aim was to update the image of what an innovator is today and who innovates. The project was announced to the VA´s netwok and readers, and winners were highlighted in a special innovation edition of the magazine.\r\n\r\nExpected results and effects:\r\nBy Veckans Affärer reaches Vinnova over 300,000 decision makers in business: online, newsletter, magazine and event.\r\n\r\nApproach and implementation:\r\nThe collaboration at the event was successful and the results were estimated according to the evaluation. All according to contract.", "funder_award_id": "2015-03188_Vinnova", "funder": {"id": "https://openalex.org/F4320321030", "display_name": "VINNOVA", "doi": "10.13039/501100001858"}, "amount": 200000.0, "currency": "SEK", "funding_type": "grant", "funder_scheme": "Project grant", "start_date": "2015-07-01", "end_date": "2015-12-01", "start_year": 2015, "end_year": 2015, "landing_page_url": "https://www.vr.se/english/swecris.html", "doi": null, "provenance": "swecris_vinnova", "lead_investigator": {"given_name": null, "family_name": "Anna Christina Iréne Jandler", "orcid": null, "role_start": "2015-07-01", "affiliation": {"name": "BONNIER BUSINESS MEDIA SWEDEN AB", "country": "Sweden", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40873987", "display_name": "Commercialization and Design of Radio Frequency Coils and Hardware for MRI", "description": "No summary - Aucun sommaire", "funder_award_id": "341861-2006", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 20000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Industrial Research Fellowships", "start_date": "2009-04-01", "end_date": "2010-03-31", "start_year": 2009, "end_year": 2009, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=341861-2006", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Robert", "family_name": "Pinkerton", "orcid": null, "role_start": null, "affiliation": {"name": "XLR Imaging", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087401543", "display_name": "Cell biological mechanisms of centromere drive", "description": "Per FOA PA-20-272 this document is not required", "funder_award_id": "3r35gm122475-05s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 88210.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R35", "start_date": "2017-09-01", "end_date": "2022-05-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/10385950", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MICHAEL", "family_name": "LAMPSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087402632", "display_name": "Carbon conversion in mixotrophic cultivation by a thermophilic cyanobaterium producing PHB", "description": "In the present research, the utilization properties of carbon and energy sources were characterized in the photomixotrophic cultures of a thermophilic cyanobacterium (Synechococcus sp.MA19) and liverwort cells (Marchantia polymorpha HYA-2F), and the following results were obtained.(1) Sucrose was selected as an organic carbon source which was utilized by strain MA19 under a photomixotrophic condition. It was found that phosphate was a key factor governing the productivity of poly-β-hydroxybutyrate (PHB) by the strain.(2) In the cultures of stratn MA19 with sucrose medium in the range of incident light intensity of 0-67 W/m^2, the cellular carbon recovery of 1.1 and CO_2 evolution ratio of -0.18 were obtained when the total light energy absorbed by the cells was 5.8×10^6 J/g-cells. This result inducated that CO_2 released via respiratory actions was trapped and reused for the cell formation by photosynthetic activity of the strain.(3) A bioreactor system was developed for the photomixotrophic cultures of M.polymorpha HYA-2F, which consisted of a glass vessel with external light irradiation and a light moderator installed in a process controller. Batch culture in the bioreactor was conducted in glucose medium while keeping the value of absorbed light energy at 3.5×10^2 W/kg by regulating incident light intensity ranging from 19 to 220 W/m^2. During this culture under light control, CO_2 evolution was suppressed and the high value of cell yield was achieved compared with that in the culture conducted at constant incident light intensity of 50 W/m^2.(4) The characteristics of energy conversion through respiratory and photosynthetic actions in the mixotrophic cells were examined based on the metabolic flux analysis. In the culture with light regulation where the efficiency of overall energy conversion to ATP was considered, the enhanced cell yield was obtained on the basis of energy provided to the system in comparison with those in the cultures without light control.", "funder_award_id": "10650785", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4000000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10650785/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Masahito", "family_name": "TAYA", "orcid": null, "role_start": null, "affiliation": {"name": "Osaka University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000060144127", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087402967", "display_name": "Community Partnership for Ethical Research", "description": " 7. PROJECT NARRATIVE This project from Virginia Commonwealth University proposes to address the challenging goal of translating best practices into the community and subsequently improving health outcomes in minority, underserved and vulnerable populations by building research partnerships with these communities. We will work with affected communities to build, monitor, adjust and evaluate a community consultation and public disclosure plan for an emergency medicine research project. We hypothesize that this community based participatory research strategy will result in open communication channels for this project and test a larger, enterprise wide, sustainable, model of community participation in biomedical and social/behavioral research.", "funder_award_id": "1rc1nr011536-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 490847.0, "currency": "USD", "funding_type": "research", "funder_scheme": "RC1", "start_date": "2009-09-23", "end_date": "2011-07-31", "start_year": 2009, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7804179", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ELIZABETH B", "family_name": "RIPLEY", "orcid": null, "role_start": null, "affiliation": {"name": "VIRGINIA COMMONWEALTH UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087405845", "display_name": "異種のフテロ元素の特性を活用したハイブリッド型不斉触媒の開発", "description": "本研究は異種のヘテロ元素の特性を活用したハイブリッド型不斉触媒を開発し新しい不斉反応の可能性を開拓するものである。まず、不斉配位子としてイミダゾール誘導体の合成を検討した。従来の触媒的不斉合成法は適用することができなかったので、光学活性な保護基の導入による不斉合成を検討した。光学活性な6-フェニルテトラヒドロピラニル基をイミダゾールの1位に導入後2位のリチオ化と続くアルデヒドへの付加により種々の(1-ヒドロキシアルキル)イミダゾール誘導体を合成した。また、光学分割による合成も行った。一方、ピラゾール誘導体の合成も検討し、軸不斉ピラゾール誘導体が得られた。これらの光学活性なヘテロ環化合物を不斉配位子として種々の反応に用いた。その結果、エノラートの不斉プロトン化でイミダゾール誘導体が60%eeを超える不斉誘起を示した。また、ランタノイド金属イオンを用いる不斉マイケル付加反応では軸不斉ピラゾール誘導体が有用で、50%ee以上の付加体が得られた。最後にサレンマンガン錯体と今回合成したヘテロ環化合物とのハイブリッド型不斉触媒による反応を検討した。サレンマンガン錯体は遊離のオレフィンの不斉エポキシ化の触媒として大変有用であることが筆者らの研究等により既に明らかになっている(有合化,53.940(1995))。この錯体に光学活性な軸配位子を導入すればさらに有用な反応になると期待される。そこで、まず光学活性な軸配位子による不斉誘起能を明らかにする目的で、アキラルなサレンマンガン錯体と種々の光学活性な軸配位子とのハイブリッド化を検討した。その結果、今回合成したイミダゾール誘導体を用いた時に初めて20%eeを超える光学純度のエポシキドが得られることが判明した。高くはないが不斉誘起が観測されたことは、反応機構などを考察するうえで大変重要である。また、不斉触媒反応における新しい方法論を提供するものとして実用上も有用であると考えている。", "funder_award_id": "07454197", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 7800000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (B)", "start_date": "1995-04-01", "end_date": "1995-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07454197/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "芳雄", "family_name": "伊藤", "orcid": null, "role_start": null, "affiliation": {"name": "Kyushu University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000221086", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087410473", "display_name": "Food Allergy Research Consortium and Statistical Center", "description": null, "funder_award_id": "1u01ai066560-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1117765.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2005-07-01", "end_date": "2010-06-30", "start_year": 2005, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/6999626", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DONALD M", "family_name": "STABLEIN", "orcid": null, "role_start": null, "affiliation": {"name": "EMMES CORPORATION", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087410604", "display_name": "Innate immune response to microbial infection", "description": null, "funder_award_id": "5p01ai044642-12", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1787757.0, "currency": "USD", "funding_type": "program", "funder_scheme": "P01", "start_date": "1999-09-30", "end_date": "2015-07-31", "start_year": 1999, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8305640", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM M.", "family_name": "NAUSEEF", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF IOWA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087410749", "display_name": "Gokova Geometry/Topology Conference", "description": "Gokova Geometry-Topology Conference will be held during the last week of May of each year in Hotel Yucelen's conference facilities in Gokova/Turkey. The annual international Gokova Geometry-Topology Conferences was founded in 1992 with the purpose of creating a lively informal environment where the latest results of Geometry and Topology are discussed by active world-renowned experts and junior researchers along with enthusiastic graduate students. Many junior now-well-known mathematicians of the field got their early international exposure in these friendly conferences. These conferences aim to increase participation of junior researchers and experts from US. Gokova conferences will continue to provide a platform for exchanging ideas between American, European and Asian mathematicians in timely fashion.\r\n\r\nThe focus topics for each conference are determined by the Scientific Committee during the previous year based on the major scientific breakthroughs that occur in the field, and on availability of outstanding speakers to present them to a broad audience of geometers and topologists. The list of the topics of current interest that the organizers hope to explore via mini-courses and/or lecture series in the next few years include: C. Manolescu's solution of the triangulation conjecture (Manolescu will be giving a minicourse in 2015 meeting); Flexibility phenomena in symplectic and contact topology (Y. Eliashberg, E. Murphy, and collaborators,one of them will be minicourse); Geometric approaches to mirror symmetry and extensions of the Strominger-Yau-Zaslow conjecture (D. Auroux, K. Fukaya, M. Abouzaid, T. Ekholm); Corks, surgeries, and exotic 4-manifolds (Akbulut, Yasui, Ruberman); Refined enumerations and knot theory (Cherednik, Goettsche, Shende). More information can be found on the conference web page.\r\n http://gokovagt.org/", "funder_award_id": "2027247", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 40086.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2020-02-14", "end_date": "2021-03-31", "start_year": 2020, "end_year": 2021, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2027247", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Clifford", "family_name": "Taubes", "orcid": null, "role_start": null, "affiliation": {"name": "Harvard University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087411060", "display_name": "酵素類似機能を有する有機金属錯体の合成とN_2, CO_2固定に関する研究", "description": "Principal Investigator：御園生 晃, Project Period (FY)：1968, Research Category：Grant-in-Aid for General Scientific Research (B)", "funder_award_id": "8708", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 8200000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (B)", "start_date": "1968-04-01", "end_date": "1968-03-31", "start_year": 1968, "end_year": 1968, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X43080------8708/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087411531", "display_name": "Chaire de recherche du Canada en études allemandes et européennes /\n\nCanada Research Chair in German and European Studies", "description": null, "funder_award_id": "52978", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 500000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Research Chairs", "start_date": "2006-04-01", "end_date": null, "start_year": 2006, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "van Rahden, Till B", "orcid": null, "role_start": null, "affiliation": {"name": "Université de Montréal", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087415427", "display_name": "Studies in cochlear hair cell transduction", "description": " Of the well over 30 million people in the US with auditory problems, the vast majority have defects in outer hair cell (OHC) function. These sensory receptor cells within the cochlea are required for normal sensitivity and frequency selectivity. Because their loss or malfunction results in major processing difficulties, our work on both normal and genetically altered OHCs is required in order to improve clinical outcomes. ", "funder_award_id": "2r01dc000089-41a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 498683.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1991-01-01", "end_date": "2016-08-31", "start_year": 1991, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8236321", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY ANN", "family_name": "CHEATHAM", "orcid": null, "role_start": null, "affiliation": {"name": "NORTHWESTERN UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087415460", "display_name": "INDIVIDUAL VARIATION IN OLFACTION", "description": null, "funder_award_id": "5r01dc000298-13", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1985-09-23", "end_date": "2000-08-31", "start_year": 1985, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2518051", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHARLES J", "family_name": "WYSOCKI", "orcid": null, "role_start": null, "affiliation": {"name": "MONELL CHEMICAL SENSES CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087415566", "display_name": "兼任取締役の忠実義務に関する研究", "description": "Principal Investigator：北村 雅史, Project Period (FY)：1992, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Civil law", "funder_award_id": "04720022", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 700000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1992-04-01", "end_date": "1992-03-31", "start_year": 1992, "end_year": 1992, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04720022/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087415716", "display_name": "Processes of litter and soil organic matter transformation during extreme drying/wetting as assessed by compoundspecific isotope approaches", "description": "Recently, intensive droughts followed by heavy rainfall can already be observed in Europe as proposed by climate models. Shifts in amount, intensity and frequency of precipitation could change soil structure and soil organic matter quality and thus turnover in temperate forest ecosystems. Contradicting results have been reported from drying and wetting experiments in field and laboratory studies or from observations of natural drying and wetting periods. To verify different interpretations, a combination of stable and radio-isotopes and biomarker .analyses seems a promising tool. This can be achieved by establishing tracer experiments in the drying and wetting fields (13C and 15NJ and in controlled laboratory studies (14C, 13C, and 15N) and by analysing the 13C, 14C and 15N signatures not only in the bulk SOM but also in biomarkers characterizing chemically defined SOM pools, e.g. microbially and plant-derived sugars, phospholipid fatty acids (PLFA) and benzenepolycarboxylic acids (BPCA). The combination of biomarker and isotope (δ13C, 14C and δ 15N) analysis allows not only deducing SOM turnover after drying / wetting but also to identify the involved microbial community and the fate of chemically defined compounds during SOM decomposition and turnover under the experimental manipulations.", "funder_award_id": "68810257", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 1099416.6538000002, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Forschungsgruppen", "start_date": "2008-01-01", "end_date": "2013-12-31", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/68810257", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087416253", "display_name": "琉球石灰岩地域の地下水・湧水, 河川水の汚染に関する研究", "description": "Principal Investigator：渡久山 章, Project Period (FY)：1984, Research Category：Grant-in-Aid for Environmental Science", "funder_award_id": "59035052", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1800000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Environmental Science", "start_date": "1984-04-01", "end_date": "1984-03-31", "start_year": 1984, "end_year": 1984, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59035052/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087417481", "display_name": "CAREER: Systematic Design of Distributed Protocols - from Methodologies and Toolkits to Systems", "description": "PROPOSAL NUMBER: CNS-0448246\r\nPRINCIPAL INVESTIGATOR: Gupta, Indranil\r\nINSTITUTION: University of Illinois at Urbana-Champaign\r\nPROPOSAL TITLE: CAREER: Systematic Design of Distributed Protocols\r\n- from Methodologies and Toolkits to Systems\r\n\r\nDistributed protocols such as resource discovery, cooperative caching, replication, etc., are crucial to the scalability and reliability of large-scale distributed systems such as the Web and the Grid. Today, however, the critical activity of designing a distributed protocol relies on an ad-hoc approach - literature, experience, and basic Computer Science knowledge provide the only assistance. This often leads to complex protocols, increased design times and costs, and eventually to inefficient use of research potential.\r\n\r\nThis project is exploring systematic techniques for designing distributed protocols, assisted by the use of Design Methodologies for distributed protocols. Design methodologies augment the creative process of protocol innovation, without stifling it. The project is creating new methodologies that systematically convert naturally observed phenomena into protocols with predictable properties. One innovative methodology translates differential equation systems into equivalent distributed protocols. Composable methodologies are also being developed, allowing protocol designers flexibility to enrich protocols with desired properties. \r\n\r\nThe methodologies invented and discovered in this project will be used to design new system designs for cooperative web caching, adaptive Grid computing, persistent distributed file systems, and disaster response and recovery. The methodologies will be made available to the community as Integrated design Toolkits (IdTs) that automate methodologies and enable a designer to automatically generate compilable code for a protocol. While methodologies have been used with varying degrees of success in other fields of science, this project is the one of the first to study its benefits and drawbacks in certain focus areas of distributed systems.\r\n", "funder_award_id": "0448246", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 456000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2005-03-01", "end_date": "2010-02-28", "start_year": 2005, "end_year": 2010, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0448246", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Indranil", "family_name": "Gupta", "orcid": null, "role_start": null, "affiliation": {"name": "University of Illinois at Urbana-Champaign", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087418119", "display_name": "Partnering with stakeholders to set research priorities in pediatric obesity management", "description": "Our purpose is to create a 'Top 10' list of research priorities for managing pediatric obesity in Canada. To achieve this goal, we will survey adolescents (n=270), caregivers (n=270), and healthcare professionals (n=100; doctors, nurses, dietitians, mental health professionals) about the questions they have related to managing pediatric obesity. We will recruit families and healthcare professionals through Obesity Canada and from pediatric obesity management clinics in Vancouver, Calgary, Edmonton, Thunder Bay, Mississauga, Toronto, Hamilton, Ottawa, and Montreal. From January to December 2023, we will complete a multi-step process called a Priority Setting Partnership, which includes (1) collecting numerous research questions from participants (in English and French), (2) organizing and refining questions, and (3) creating a 'Top 10' list of research priorities. Our team has a long, successful history of conducting research together. This study will generate a list of questions that we will use to plan future research related to managing pediatric obesity. The information we learn from this study will ensure that our future research addresses topics that are most important to families and healthcare professionals.", "funder_award_id": "185519_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 10000.0, "currency": "CAD", "funding_type": "planning", "funder_scheme": "Planning and Dissemination Grant - Institute Community Support", "start_date": "2023-01-01", "end_date": "2023-12-31", "start_year": 2023, "end_year": 2023, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Geoff", "family_name": "Ball", "orcid": null, "role_start": "2023-01-01", "affiliation": {"name": "University of Alberta", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087419710", "display_name": "BIFUNCTIONAL CHELATING AGENTS IN TUMOR LOCALIZATION", "description": null, "funder_award_id": "5r37ca016861-20", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R37", "start_date": "1978-06-01", "end_date": "1995-05-31", "start_year": 1978, "end_year": 1995, "landing_page_url": "https://reporter.nih.gov/project-details/2086541", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CLAUDE F.", "family_name": "MEARES", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA DAVIS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087423759", "display_name": "BIOLOGY OF ONCOGENES AND TUMOR SUPPRESSOR GENES", "description": null, "funder_award_id": "5p01ca042063-17", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1551611.0, "currency": "USD", "funding_type": "program", "funder_scheme": "P01", "start_date": "1986-05-01", "end_date": "2006-04-30", "start_year": 1986, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6512368", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PHILLIP A", "family_name": "SHARP", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087423891", "display_name": "Responsivity Biomarkers of Maximum Oxygen Consumption in Aerobic Training: A Metabolomics Approach", "description": "Maximal Oxygen Consumption (VO2MAX) is the gold standard measurement of cardiorespiratory fitness levels, and is positively associated with maintenance and health enhancement. Even though the recommendations for aerobic levels enhancements can promote benefits for the great majority of people, the responses may vary from individual to individual, who will be classified as either high or low responders. The understanding of factors related to aerobic training responsivity, as well as identification of specific biomarkers that can assist in individual response capacity diagnosis, may contribute to an adoption of more efficient and biologically individualized training strategies. Thus, the current study will investigate metabolic biomarkers in skeletal muscles and blood samples related to the responsivity of 68 healthy young men (18-30 years old) to VO2MAX. Subjects will undergo 8 weeks of continuous aerobic training (TAC - 40 min/day, 3-4 times/week with 70% heart rate reserve, n=34) and high intensity interval training (HIIT - 40 min/day, 3-4 times/week with 50-90% heart rate reserve, n=34) using a cycle ergometer. Blood samples and muscle tissue (vastus lateralis) will be collected pre and post training protocol. All samples will be analyzed through metabolomics method (1H NMR spectroscopy). The main goal is identifying metabolites that can be predictors of enhancement in VO2MAX due to individual responses. After the training protocol, based on the changing magnitude of VO2MAX the individuals will be classified as either \"\"high\"\" or \"\"low\"\" responders after. Finally, metabolites identification will be used to explain differences in VO2MAX of \"\"high\"\" and \"\"low\"\" responders after TAC and HIIT program. Identification will be found through correlations and multivariate statistical analysis such as principal components analysis (PCA), partial least squares discriminant analysis (PLS-DA) and linear regressions. Receiver operating characteristic curve (ROC) will be utilized to characterize metabolites and biomarkers, their accuracy will be assessed through sensibility and specificity tests. (AU)", "funder_award_id": "16/05741-7", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "grant", "funder_scheme": "Auxílio à Pesquisa - Regular", "start_date": "2016-10-01", "end_date": "2019-03-31", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://bv.fapesp.br/en/auxilios/16-05741-7/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Mara", "family_name": "Patricia Traina Chacon Mikahil", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade Estadual de Campinas (UNICAMP). Faculdade de Educação Física (FEF)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087425802", "display_name": "SPECIFICITY OF RNA TRANSPORT IN VITRO", "description": null, "funder_award_id": "7r01ca040145-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1987-07-01", "end_date": "1988-06-30", "start_year": 1987, "end_year": 1988, "landing_page_url": "https://reporter.nih.gov/project-details/3179699", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GARY A", "family_name": "CLAWSON", "orcid": null, "role_start": null, "affiliation": {"name": "GEORGE WASHINGTON UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087429512", "display_name": "血管新生部の血管内皮細胞と周細胞との細胞質突起相互陥入の三次元電顕免疫学的研究", "description": "Principal Investigator：和久井 信, Project Period (FY)：1991, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：基礎獣医学", "funder_award_id": "03856073", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1200000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1991-04-01", "end_date": "1991-03-31", "start_year": 1991, "end_year": 1991, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03856073/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087429666", "display_name": "Biomedical Informatics Research Training at Oregon Health & Science University", "description": "Project Narrative The Oregon Health & Science University (OHSU) Biomedical Informatics Fellowship Program trains future researchers and leaders in biomedical and health informatics, the field devoted to improving personal health, health care, public health, and biomedical research through the use of information and its associated technologies. This National Library of Medicine (NLM) Training Grant will enable us to support predoctoral (PhD students) and postdoctoral fellows for training that includes courses, research, and related activities. This proposal is a competitive renewal for a fifth five-year cycle of funding for the OHSU program, which has been a leader and innovator in the program for 20 years.", "funder_award_id": "4t15lm007088-25", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1199256.0, "currency": "USD", "funding_type": "training", "funder_scheme": "T15", "start_date": "1992-07-01", "end_date": "2017-06-30", "start_year": 1992, "end_year": 2017, "landing_page_url": "https://reporter.nih.gov/project-details/9086417", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM R", "family_name": "HERSH", "orcid": null, "role_start": null, "affiliation": {"name": "OREGON HEALTH & SCIENCE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408743156", "display_name": "SBIR Phase I: Improved Photoionization Source for LC/MS Analysis for Food Safety", "description": "This Small Business Innovation Research (SBIR) Phase I project will lead to a new technology for analyzing contaminants in food substances. This is an extremely challenging analytical problem due to the vast range of contaminants that need to be screened and the complex and varied matrices of different food commodities. The state-of-the-art in analysis is based on electrospray ionization (ESI) and liquid chromatography mass spectrometry (LC-MS). Unfortunately for environmental and biological samples ESI suffers several limitations including matrix ion suppression, poor dynamic range, and inability to ionize nonpolar compounds. We will significantly improve on the analytical accuracy of food contaminants by implementing atmospheric pressure photoionization (APPI), which allows much better control of the undesirable ion-molecule chemistry that plagues ESI. We will test combined ESI/APPI configurations and modes of operation and achieve critical control of ion-molecule interactions from dual ionization. A total system approach will be investigated to develop the optimum technology solution.\r\n\r\nThe broader/commercial impacts of this research are: (i) significantly improved analysis of harmful compounds in foods providing significant societal benefit in terms of health, well being, and lower healthcare costs, (ii) significant new revenue to Syagen through increased sales off APPI-based products, (iii) improve the technical competitiveness of the U.S. in food safety for which Europe currently leads, and (iv) increase the value proposition for expensive analytical instrumentation by improving the quality and speed of chemical analyses.", "funder_award_id": "1013488", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 98598.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2010-07-01", "end_date": "2010-12-31", "start_year": 2010, "end_year": 2010, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1013488", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Jack", "family_name": "Syage", "orcid": null, "role_start": null, "affiliation": {"name": "SYAGEN TECHNOLOGY INC", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087432136", "display_name": "Preterm Infants: Light Effects on Health and Development", "description": null, "funder_award_id": "5r01nr008044-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 201507.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-02-01", "end_date": "2009-01-31", "start_year": 2003, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7172600", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DEBRA H", "family_name": "BRANDON", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087437692", "display_name": "RESEARCH FOR THE PATHOMECHANISM, EPIDEMILOGY AND TREATMENTS FOR HAM AND HTLV-I RELATED DISORDERS.", "description": "This research provided several important results during these two years of investigation. In Kasari-town, which is a remote island in Kagoshima, we examined 384 inhabitants. Among them, 36(9.4%) had anti-HTLV-I antibodies in the serum. A longitudinal study of carriers will be done in the coming ten years. Lymphocyte separation was performed from 800 patients and family members who were admitted at Kagoshima University hospital. All of these samples were stored in liquid nitrogen.The clinical features and the laboratory data of 208 patients with HAM were entered in the computer for analysis. The results provided several important information regarding HAM. For instance, HAM may not sometimes have anti-HTLV-I antibodies in cerebrospinal fluid. The associated diseases in patients with HAM were also analyzed and their prevalence were calculated. The pathomechanisms of HTLV-I associated arthropathy, alveolitis, Shjogren syndrome, myositis. IgA nephropathy and pseudohypoparathyroidism were investigated and several important findings could be obtained. Five autopsied cases HAM were studied for neuropathological analysis. The specific importance of CD8lymphocytes was observed. Cytotoxic CD8 cells for the pX region were also found in the blood of patients. More than ten different therapeutic regimens were tried in HAM with very encouraging results.", "funder_award_id": "03454219", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 6200000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454219/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Mitsuhiro", "family_name": "OSAME", "orcid": null, "role_start": null, "affiliation": {"name": "KAGOSHIMA UNIVERSITY", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010041435", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087437986", "display_name": "EPSTEIN-BARR VIRUS AND AUTOIMMUNE DISEASE", "description": null, "funder_award_id": "7r01ar021175-14", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1990-07-01", "end_date": "1993-01-31", "start_year": 1990, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3155162", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN H", "family_name": "VAUGHAN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA SAN DIEGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087439491", "display_name": "MicroRNAs in Tissue-resident memory T cells", "description": "Narrative A defining feature of the immune system is the existence of memory cells, which originate in response to an infection, and provide durable immunity during subsequent infections; tissue-resident memory (TRM) cells are one class of memory cells, and reside in each adult tissue and provide localized response to infection. Here, we propose to systematically examine whether microRNAs, a class of gene regulatory RNAs, contribute to TRM cell regulatory programs, using human and mouse cells. This study is a pivotal first step towards understanding how specific miRNAs can be used to promote more durable immunity by increasing the formation and survival of TRM cells.", "funder_award_id": "1r21ai166433-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 214841.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2022-04-11", "end_date": "2024-03-31", "start_year": 2022, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10354926", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANDREW W", "family_name": "GRIMSON", "orcid": null, "role_start": null, "affiliation": {"name": "CORNELL UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087441001", "display_name": "CAREER : Filling In the Design Landscape of Probabilistic Programming Languages", "description": "Probabilistic behavior is pervasive in computing, so it is critical that we have tools for reasoning about it in our programs. Probabilistic programming languages (PPLs) address this need by enriching programming languages with probabilistic semantics, enabling applications in software verification and artificial intelligence that rely on reasoning about the uncertain behavior. The challenge is scalability: probabilistic inference is computationally hard, even for very restricted programming languages. However, scaling inference is not hopeless: its inherent hardness can be tamed by careful language design. There are special PPLs, called tractable probabilistic models, for which inference is computationally easy. Unfortunately, tractable probabilistic models are too low-level to ergonomically program in. The goal of this project is to bridge the gap between high-level ergonomic languages and low-level tractable languages. This project's novelty is a new compiler-oriented approach to designing and implementing PPLs: the team will (1) develop new high-level ergonomic PPLs that compile to low-level tractable probabilistic models; (2) develop new compilation targets that enable scalable probabilistic inference for richer classes of programs; and (3) create new PPLs for teaching probability to broad audiences. This project's impact is a new generation of scalable, reliable, and usable PPLs, enabling new applications in software verification and artificial intelligence.\r\n\r\nTo achieve these goals, the project will fill in the design landscape for probabilistic programming language design and implementation. The key tradeoff in designing a PPL is between tractability and expressivity of the language. More tractable languages afford efficient and scalable inference strategies but are not easy to program in. More expressive languages have ergonomic programming features like loops, data structures, and modules, but these features make performing inference hard. The project's first research thrust will develop and grow a new expressive compiled PPL that supports a significant subset of the Racket programming language. The project's second thrust will use type systems to develop new tractable probabilistic programming languages that ensure high-performance Markov-Chain Monte-Carlo sampling with guarantees on mixing times. The project's final thrust will develop a sequence of increasingly rich PPLs for teaching probability to broad audiences. The project's education plan will enable (1) a new pedagogy for teaching probability using probabilistic programs; and (2) new courses on probabilistic programming. The project's broader impacts are (1) development of new educational tools for teaching probability to broad audiences; (2) technology transfer of probabilistic programming tools and techniques into industry and government; and (3) empowering a broader set of developers to create machine learning models.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2442685", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 674830.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2025-06-01", "end_date": "2030-05-31", "start_year": 2025, "end_year": 2030, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2442685", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Steven", "family_name": "Holtzen", "orcid": null, "role_start": null, "affiliation": {"name": "Northeastern University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087442453", "display_name": "Network-based Analysis of Kinetics and Regulation", "description": null, "funder_award_id": "1r01gm068837-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 278692.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-07-15", "end_date": "2007-06-30", "start_year": 2003, "end_year": 2007, "landing_page_url": "https://reporter.nih.gov/project-details/6672030", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BERNHARD O", "family_name": "PALSSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA SAN DIEGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087442739", "display_name": "THE EPIDEMIOLOGY OF EARLY REPRODUCTIVE LOSS", "description": null, "funder_award_id": "2r01hd015909-06", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1982-04-01", "end_date": "1989-11-30", "start_year": 1982, "end_year": 1989, "landing_page_url": "https://reporter.nih.gov/project-details/3313305", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JENNIE KATHERINE", "family_name": "KLINE", "orcid": null, "role_start": null, "affiliation": {"name": "NEW YORK STATE PSYCHIATRIC INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087449704", "display_name": "Presidential Award for Excellence in Secondary Mathematics (PA)", "description": null, "funder_award_id": "9155667", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 7500.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1991-09-15", "end_date": "1994-09-30", "start_year": 1991, "end_year": 1994, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9155667", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Julianna", "family_name": "Csongor", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087453330", "display_name": "Rhenium-Osmium Isotope Study of the Mantle", "description": "9526329 Walker Despite its importance in understanding the chemical evolution of the Earth, the Os isotopic composition of the mantle is poorly constrained. This is to continue characterization of the Os isotopic composition of various mantle domains through time, via the analysis of ultramafic rocks that are otherwise geochemically and isotopically well-characterized, and that have relatively high Os concentrations and low Re/Os ratios. Specific targets for analysis will be ultramafic magmatic systems that represent upper oceanic lithospheric materials, and materials derived from likely mantle plumes. Both whole rock samples and mineral separates will be analyzed from each location. The resulting information should lead to: 1) a better understanding of how Os has evolved in plume and upper mantle reservoirs, and 2) provide insights into where Re and Os are sited in these types of rocks and what phases or combination of phases provide the most useful information about initial isotopic compositions.", "funder_award_id": "9526329", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 110000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1996-03-01", "end_date": "1998-02-28", "start_year": 1996, "end_year": 1998, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9526329", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Richard", "family_name": "Walker", "orcid": null, "role_start": null, "affiliation": {"name": "University of Maryland, College Park", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087456322", "display_name": "Coordinated Regulation of Virulence Genes in C. neoformans", "description": " In order to better treat infectious diseases, we must understand the ways in which infectious microorganisms survive within their host. The experiments in this proposal will study Cryptococcus neoformans, an important opportunistic fungal pathogen in AIDS patients, to define the cellular factors required for formation of a protective surface capsule. Capsule production will also be used as a model to better understand more fundamental issues of the interaction between microorganisms and the infected host. ", "funder_award_id": "5r01ai074677-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 385931.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2011-07-01", "end_date": "2016-06-30", "start_year": 2011, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8859954", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANDREW", "family_name": "ALSPAUGH", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087456778", "display_name": "INSERTIONAL MUTANTS AND DEVELOPMENT IN TRANSGENIC MICE", "description": null, "funder_award_id": "2r01gm024872-15", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1977-06-01", "end_date": "1995-11-30", "start_year": 1977, "end_year": 1995, "landing_page_url": "https://reporter.nih.gov/project-details/3272596", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MIRIAM H", "family_name": "MEISLER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087457113", "display_name": "MODULATION OF GLOMERULAR ULTRAFILTRATION COEFFICIENT", "description": null, "funder_award_id": "7r01dk022040-15", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1978-07-01", "end_date": "1996-01-31", "start_year": 1978, "end_year": 1996, "landing_page_url": "https://reporter.nih.gov/project-details/2137639", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "VIRGINIA J", "family_name": "SAVIN", "orcid": null, "role_start": null, "affiliation": {"name": "MEDICAL COLLEGE OF WISCONSIN", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408745806", "display_name": "Preeclampsia and Autoimmunity", "description": null, "funder_award_id": "2r01hd034130-11a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 285202.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1996-05-07", "end_date": "2013-01-31", "start_year": 1996, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7373924", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RODNEY E", "family_name": "KELLEMS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087459166", "display_name": "ヘムタンパク質及び金属ポルフィリンの機能及び構造とそれらの分子制御に関する研究", "description": "Principal Investigator：城 宣嗣, Project Period (FY)：1986, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：工業物理化学", "funder_award_id": "60790122", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1040000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1986-04-01", "end_date": "1986-03-31", "start_year": 1986, "end_year": 1986, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60790122/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087459499", "display_name": "Factors affecting compensation decisions of Canadian firms, and the impact of compensation schemes on managerial decision-making", "description": null, "funder_award_id": "1438", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 48000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Standard Research Grants", "start_date": "1998-04-01", "end_date": null, "start_year": 1998, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Mawani, Amin", "orcid": null, "role_start": null, "affiliation": {"name": "University of British Columbia", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408745959", "display_name": "Collaborative Research: ATD: a-DMIT: a novel Distributed, MultI-channel, Topology-aware online monitoring framework of massive spatiotemporal data", "description": "Given current technological, societal and environmental changes, we face ever more diverse potentially destructive threats. Technology has enabled the collection of massive spatiotemporal datasets, which can be used for real-time identification of potential threats. The complexities of such data create exciting challenges for online threat detection, involving the learning and integration of complex nonlinear embeddings for efficient monitoring, the fusion of multiple spatiotemporal data sources for improving detection performance, and scalability for real-time implementation on distributed computing systems. This project will develop a novel Distributed, MultI-source, Topology-aware (a-DMIT) online threat detection framework that tackles these challenges for massive, high-dimensional spatiotemporal data. In developing reliable, scalable and versatile threat detection methods (supported by theory and algorithms), a-DMIT has the potential to improve national health and defense in a broad range of areas, including environmental monitoring, crime monitoring and mobile health. The a-DMIT project will contribute to education by involving undergraduate and graduate students in the research, and developed software will be made publicly available. \r\n\r\na-DMIT will develop three new detection methods that jointly tackle fundamental challenges in online monitoring of massive data streams. The first method, called PERsistence diagram-based ChangE-PoinT detection (PERCEPT), is a novel non-parametric, topology-aware algorithm that extends state-of-the-art tools in topological data analysis for efficient monitoring of high-dimensional data streams. The second, called MUlti-source Monitoring via Gaussian Processes (MUM-GP), is an efficient online Bayesian non-parametric detection method for multi-source spatiotemporal data. The third, called Conditional Auto-Regressive Distributed (CARD) detection, is an online spatiotemporal network monitoring procedure that leverages neighboring spatial information in a distributed and decentralized fashion. a-DMIT will be usable for a wide range of modern threat detection applications, including environmental monitoring, crime monitoring, satellite image monitoring and power grid security.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2220496", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 99772.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2023-08-15", "end_date": "2026-07-31", "start_year": 2023, "end_year": 2026, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2220496", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Simon", "family_name": "Mak", "orcid": null, "role_start": null, "affiliation": {"name": "Duke University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087461541", "display_name": "Determination of the Physical and Mechanical Properties of Fluid-Saturated Porous Rocks Using the Pressure Pulse Technique", "description": null, "funder_award_id": "7609095", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 43300.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1976-09-01", "end_date": "1979-02-28", "start_year": 1976, "end_year": 1979, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7609095", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Ching", "family_name": "Yew", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087462662", "display_name": "New Methods for the Synthesis of Alkaloids", "description": null, "funder_award_id": "5r01gm049093-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 229890.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1993-05-01", "end_date": "2005-04-30", "start_year": 1993, "end_year": 2005, "landing_page_url": "https://reporter.nih.gov/project-details/6636075", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JEFFREY", "family_name": "AUBE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF KANSAS LAWRENCE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087465015", "display_name": "Mittelassyrische Urkunden aus dem Archiv Assur 14446 (Hervé Reculeau/Barbara Feller)", "description": "Mit dem Band von Herve Reculeau und Barbara Feiler, Mittelassyrische Urkunden aus dem Archiv Assur 14446 wird ein weiterer Bestand mittel assyrischer Urkunden aus Assur zugänglich gemacht. Die hierin enthaltenen Texte gehören zu den frühesten mittelassyrischen Urkunden aus der Stadt Assur und auch aus dem übrigen assyrischen Raum. Es handelt sich weitgehend um private Rechtsurkunden. Sie sind Teil eines umfangreichen Fundbestandes, der von Familien aus vier aufeinander folgenden Generationen stammt. Die auf den Urkunden angebrachten Abrollungen von Siegeln dokumentieren die älteste Phase mittelassyrischer Glyptik. Von Bedeutung ist es, dass zahlreiche der abgerollten Siegel zur Mittani-Kerkuk-Glyptik gehören. Durch die gegenwärtig mögliche chronologische Zuordnung der Urkunden werden für die frühe mitte!assyrische Glyptik aus Assur zeitliche Parameter gesetzt.", "funder_award_id": "228614081", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 109941.6654, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Publikationsbeihilfen", "start_date": "2012-01-01", "end_date": "2013-12-31", "start_year": 2012, "end_year": 2013, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/228614081", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087465535", "display_name": "Improving Vocabulary Learning through Working Memory Training: Examination of Causal Effects and Learning Trajectories", "description": "One of the biggest challenges in education is promoting oral language development. In particular, vocabulary learning is key for the development of higher-order oral language and literacy skills. New insights from theory and evidence-based approaches will help children build this foundational skill which in turn will ensure success in school. To this end, researchers will examine the extent to which vocabulary learning is influenced by a cognitive factor (i.e., working memory) and an environmental factor (i.e., input frequency and quality). The two primary goals are to develop and examine the feasibility of implementing working memory training for young children, and to develop working memory training on vocabulary learning, with the potential of mitigating effects of impoverished input often associated with children from low socio-economic (SES) backgrounds. \r\n\r\nThis project focuses on the causal role of cognition (i.e., working memory) in vocabulary learning for young children. In the first year, the researchers will develop several child-friendly and engaging working memory training modules to examine whether working memory training improves vocabulary learning in general, as well as working memory for children from low SES backgrounds. In the second year, the training modules will be implemented in a small-scale pilot trial where children are randomly assigned to four conditions: (1) working memory training; (2) vocabulary training; (3) combined training on working memory and vocabulary; and (4) business-as-usual control. The findings are expected to provide proof-of-concept for development of a causal model of working memory in vocabulary learning, which can inform the development and design of interventions to improve vocabulary learning.", "funder_award_id": "1729039", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 300000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2017-08-15", "end_date": "2020-07-31", "start_year": 2017, "end_year": 2020, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1729039", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Young-Suk Grace", "family_name": "Kim", "orcid": null, "role_start": null, "affiliation": {"name": "University of California-Irvine", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087466462", "display_name": "EXPRESSION OF IMMUNOGLOBULIN GENES", "description": null, "funder_award_id": "1r01hd019488-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1985-04-01", "end_date": "1990-03-31", "start_year": 1985, "end_year": 1990, "landing_page_url": "https://reporter.nih.gov/project-details/3316749", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "URSULA B", "family_name": "STORB", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WASHINGTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087468430", "display_name": "Studying human dendritic cells and DC-SIGN in HIV transmission in vivo using an improved humanized mouse model", "description": "PROJECT NARRATIVE This exploratory study will produce an optimized animal model to study HIV transmission in vivo. Using this mode, we will investigate the role of dendritic cell and its cell surface receptor in HIV transmission. This study will reveal cellular and molecular mechanisms that link HIV transmission to microbial stimuli. ", "funder_award_id": "1r21od023291-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 200000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2017-03-15", "end_date": "2019-02-28", "start_year": 2017, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/9253902", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KANG", "family_name": "LIU", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087469728", "display_name": "Aboriginal/feminist solidarity around violence against women: challenges and possibilities", "description": null, "funder_award_id": "44528", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 116666.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Graduate Scholarship - Doctoral", "start_date": "2007-04-01", "end_date": null, "start_year": 2007, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "D'Arcangelis, Carol Lynne", "orcid": null, "role_start": null, "affiliation": {"name": "University of Toronto", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087470817", "display_name": "放射線核医学領域における多種モダリティーの3次元画像間の位置合わせ手法の確立", "description": "Principal Investigator：笹山 哲, Project Period (FY)：1992, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Radiation science", "funder_award_id": "04770744", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1992-04-01", "end_date": "1992-03-31", "start_year": 1992, "end_year": 1992, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04770744/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087471394", "display_name": "Discovery and characterization of ocular regulatory elements through evolutionary analysis", "description": "Project Narrative This research project promises to deliver a number of insights into the evolution of gene expression in the eye and congenital eye disease. By contrasting the genomes of blind and sighted mammal species, it will pinpoint regions of DNA important for vision and which are likely to be involved in human eye diseases. The project will then explicitly test for mutations in these regions in patients with congenital eye disease.", "funder_award_id": "5r01ey030546-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 515995.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2020-07-01", "end_date": "2023-06-30", "start_year": 2020, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10445290", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARIA D", "family_name": "CHIKINA", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF UTAH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087472900", "display_name": "FUNCTIONAL GENOMICS AND MECHANISM OF BCL11B ACTION IN LYMPHOCYTE COMMITMENT", "description": "PROJECT NARRATIVE Human genetic studies suggest that much of the genetic susceptibility to disease is related to the machinery that controls gene expression, more than defects in the genes themselves. Current experimental techniques enable researchers to catch glimpses of actual gene regulators at work all across the genome, an important step toward being able to diagnose and eventually correct gene regulation problems, but much remains to be learned about how to control the regulators' effects. For example, Bcl11b is a vital regulator of gene expression for the immune system, which has to work properly to avoid leukemia, yet it controls different genes in different kinds of immune cells even though they have identical DNA. This proposal identifies the additional gene regulation mechanisms that explain how Bcl11b works different ways in different immune cells.", "funder_award_id": "5r01ai135200-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 632343.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2018-05-04", "end_date": "2023-04-30", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10137179", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ELLEN V.", "family_name": "ROTHENBERG", "orcid": null, "role_start": null, "affiliation": {"name": "CALIFORNIA INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087477652", "display_name": "植物生長物質コチレニン類による新たなヒト骨髄性白血病治療薬の創製基礎研究", "description": "コチレニンAによる新たなヒト骨髄性白血病細胞分化誘導活性に注目し、その入手可能な構造類似化合物のフシコクシン(FC)についても構造と活性の両面から検討を行い、がん細胞分化誘導活性について重要な部分構造の特定を試みる。これらの動物実験系における有効性についても検討を加え、コチレニンAに優る強力なヒトがん細胞制御作用物質の創製を目指す。1)ヒト白血病細胞分化誘導活性におけるコチレニンとフシコクシンの構造・活性相関の検討これまでに調製した各種誘導体について、ヒト骨髄性白血病細胞分化誘導活性を評価した。(1)コチレニンAから誘導した糖鎖エポキシドの各種化学変換物では、何れもコチレニンAより細胞分化誘導活性が低下した。(2)コチレニンと同じ3α-ヒドロキシ基を有するFC-Jと3'-デアセチル-FC-Aの各化合物(3α-OH-FC-J, FC-R)においては、分化誘導活性は認められなかった。(3)コチレニンFとIは、それぞれ糖の6'位にエポキシド側鎖とオレフィン側鎖を有するが、分化誘導活性は前者に強く現れた。(4)FC-Jの糖部にエポキシド側鎖を導入した新誘導体(FC-JE,2)を参照)は、分化誘導活性はほとんどなく、細胞毒性が強まった。以上の事から、分化誘導活性に必要な構造は、糖側鎖のエポキシドの存在、およびアグリコン部分の3,12位の両水酸基の欠如と考えられた。現在、FCの12位水酸基の除去とエポキシド糖側鎖の導入について検討を行い、貴重なFC-Jを用いる実験において目的の誘導体が得られる見通しとなっている。2)フシコクシン類の各種誘導体の調製(前年度からの継続研究)Phomopsis amygdali F6株の培養により、貴重なFC-Jを数100mg調製した。得られたFC-Jを塩酸で処理し、そのデイソペンテニル誘導体を調製した。この糖部分にエポキシドを有する側鎖を4',6'間にアセタール型に導入した誘導体を調製した。新たなエポキシ側鎖を有するFC-J誘導体(FC-JE)は4種のジアステレオマー混合物であるが、この細胞分化誘導活性を評価した。結果については前項に記述した。", "funder_award_id": "15658036", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3200000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Exploratory Research", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15658036/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "武史", "family_name": "佐々", "orcid": null, "role_start": null, "affiliation": {"name": "Yamagata University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000080023456", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087479121", "display_name": "Genomic analysis of pediatric SIRS and septic shock", "description": null, "funder_award_id": "2r01gm064619-04a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 332396.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2001-12-01", "end_date": "2010-08-31", "start_year": 2001, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7262272", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HECTOR R", "family_name": "WONG", "orcid": null, "role_start": null, "affiliation": {"name": "CINCINNATI CHILDRENS HOSP MED CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087480256", "display_name": "PITUITARY ROLE IN ESTROGEN-EVOKED GONADOTROPIN RELEASE", "description": null, "funder_award_id": "5r01hd018591-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1983-08-01", "end_date": "1989-03-31", "start_year": 1983, "end_year": 1989, "landing_page_url": "https://reporter.nih.gov/project-details/3315670", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "REID L.", "family_name": "NORMAN", "orcid": null, "role_start": null, "affiliation": {"name": "TEXAS TECH UNIVERSITY HEALTH SCIS CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087480543", "display_name": "Grundlagen einer konsistenten Charakterisierung und Bemessung von WAAMgefertigten Stahlbauteilen bei hoher Abschmelzleistung", "description": "Mit der Wire Arc Additive Manufacturing (WAAM) eröffnen sich dem Stahlbau außerordentlich große Perspektiven neuer Gestaltungs- und Einsatzmöglichkeiten. Jedoch sind sowohl die Technologie in Hinblick auf eine im Stahlbau erforderliche Fertigungsgeschwindigkeit als auch die stahlbaumäßige Bemessung unter Berücksichtigung der prozess-und bauteilbedingten Unregelmäßigkeiten von Geometrie und Struktur noch in weiten Teilen unerforscht. Dabei sind die Fertigungstechnologie und die der Bemessung zugrundeliegenden Charakteristika von mit WAAM hergestellten Bauteilen miteinander eng verbunden. Die Erforschung der für den Stahlbau erforderlichen Grundlagen zur Schaffung erhöhter Abschmelzleistungen und Fertigungssicherheit im Bereich der WAAM, der geometrischen und strukturellen Merkmalscharakterisierung, sowie die Grundlagen einer mit Fertigung und Charakterisierung konsistenten Bemessung von WAAM-gefertigten Stahlbauteilen mit „freier Form“ sind deswegen Gegenstand dieses Projekts. Auf der Fertigungsseite betrifft dies die Erhöhung der Abschmelzleistung unter sicherer Abschätzung von Verzug und Eigenspannungen, die Optimierung des Fertigungsergebnisses in mechanisch-technologischer Hinsicht unter Berücksichtigung der einsetzbaren Drahtwerkstoffe sowie die Weiterentwicklung und Integration der Automatisierungsprozesse. Dies betrifft auch die Parametrierung, Steuerung und Bahnkurvenprogrammierung. Nach der Klärung von prinzipiell machbaren Topologien beziehen sich die Fragestellungen weiter auf das Finden von geeigneten Parameterkonstellationen der Fertigung, um gewünschte Material- und Geometrieeigenschaften sicher zu erreichen, sowie auf die Charakterisierung des gefertigten Bauteils hinsichtlich Material und Geometrie. Neben Festigkeitsverteilungen und dem Einfluss der Eigenspannungen beeinflussen insbesondere die Oberflächenrauheit, sich ergebende Dickenabweichungen und Welligkeiten der Bauteilwandung die für die Bemessung zu verwendenden charakteristischen Werte für Geometrie und Material. Hierfür werden statistische Merkmale abgeleitet. Es wird sodann auf ein Konzept von Fertigungsklassen abgezielt, deren charakteristische Merkmale die Bemessung wieder aufgreift. Hierzu sind die zu erwartenden Bauteilformen und Bemessungsfälle sowie die Fertigung incl. Automatisierung zu berücksichtigen. Fertigung und Bemessung müssen untereinander abgestimmt sein, da die strukturmechanischen Eigenschaften des Bauteils von der fertigungsbedingten Beschaffenheit abhängen. Darauf aufbauend beziehen sich die Fragestellungen der Bemessung auf ein möglichst zweckmäßiges Nachweiskonzept, in dem die diversen Bemessungsfälle eingebettet werden können. Unter Berücksichtigung der aus dem WAAM-Prozess entstammenden Material- und Geometrieabweichungen sollen der Bauteilwiderstand unter Zugspannungen, das Stabilitätsverhalten sowie die Ermüdungsfestigkeit unter besonderer Berücksichtigung des streuenden Charakters der Merkmale des additiv gefertigten Bauteils erforscht werden.", "funder_award_id": "539093885", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 219883.3308, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "2024-01-01", "end_date": "2024-12-31", "start_year": 2024, "end_year": 2024, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/539093885", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087482800", "display_name": "Genetic and Molecular Analyses of Human LINE-1 Retrotransposition", "description": "Narrative The average human genome contains ~100 active Long INterspersed Element-1 (LINE-1 or L1) sequences that can mobilize to new genomic locations by a process known as retrotransposition. L1 retrotransposition events in the germ line, during early development, or in somatic cells generate inter- and intra-individual genetic diversity and are implicated in a myriad of sporadic genetic diseases, including Hemophilia A, Duchenne muscular dystrophy, and certain cancers. The goal of this R01 proposal is to use a cultured cell retrotransposition assay in conjunction with an integrative strategy that involves genetic, molecular biological, biochemical, multi- omic, and computational approaches to: (i) elucidate how L1s move to new genomic locations; and (ii) determine how host factors act to restrict or facilitate L1 retrotransposition. This knowledge will provide insights into how L1 retrotransposition contributes to human disease, human genetic variation, and human genome evolution.", "funder_award_id": "5r01gm060518-16", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 319163.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1999-09-30", "end_date": "2025-03-31", "start_year": 1999, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10593098", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN V.", "family_name": "MORAN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087482944", "display_name": "Global governance and human security", "description": null, "funder_award_id": "32672", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 17500.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Graduate Scholarships Program - Masters Scholarships", "start_date": "2005-04-01", "end_date": null, "start_year": 2005, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Shull, Aaron R.W.", "orcid": null, "role_start": null, "affiliation": {"name": "Carleton University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087485248", "display_name": "Modelling Uncertainty in Modern Power Systems", "description": "Big data solutions; Data mining; Demand-side management; demand-side resources; Electricity markets; Forecasting; Optimization under Uncertainty; Power system planning; Power systems operation; Renewable energy integration", "funder_award_id": "rgpin-2018-04247", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 46000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Discovery Grants Program - Individual", "start_date": "2021-04-01", "end_date": "2022-03-31", "start_year": 2021, "end_year": 2021, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=RGPIN-2018-04247", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Hamidreza", "family_name": "Zareipour", "orcid": null, "role_start": null, "affiliation": {"name": "University of Calgary", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087487272", "display_name": "Pathways from genotype and environment to melanoma", "description": null, "funder_award_id": "2r01ca088363-06a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 292942.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2001-09-30", "end_date": "2013-01-31", "start_year": 2001, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7373051", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "NICHOLAS K", "family_name": "HAYWARD", "orcid": null, "role_start": null, "affiliation": {"name": "QUEENSLAND INSTITUTE OF MEDICAL RESEARCH", "country": "AUSTRALIA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408749103", "display_name": "Dennis Brooks | University of Florida - Estados Unidos", "description": "A Sociedade Latina Americana de Oftalmologia Veterinária e o Colégio Brasileiro de Oftalmologia Veterinária congregam interessados na especialidade. As reuniões tem propiciado a troca de informações e discussão de assuntos emergentes sendo que temas como catarata, ceratites, glaucoma e uveítes serão desenvolvidos. O professor Dennis Brooks proferirá conferências sobre sua área de atuação bem como participará de WetLab em facoemulsificação e atendimento de casos clínicos no Serviço de Oftalmologia da FMVZ USP. (AU)", "funder_award_id": "97/02387-5", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "fellowship", "funder_scheme": "Auxílio à Pesquisa - Pesquisador Visitante - Internacional", "start_date": "1997-06-11", "end_date": "1997-06-17", "start_year": 1997, "end_year": 1997, "landing_page_url": "https://bv.fapesp.br/en/auxilios/97-02387-5/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Paulo", "family_name": "Sergio de Moraes Barros", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408749151", "display_name": "Student Elective Prize for Mr Prashen Pillay", "description": "Preconceptions of labour pain amongst antenatal women. A transatlantic twin centre comparative study", "funder_award_id": "360G-Wellcome-087287_Z_08_Z", "funder": {"id": "https://openalex.org/F4320311904", "display_name": "Wellcome Trust", "doi": "10.13039/100010269"}, "amount": 1000.0, "currency": "GBP", "funding_type": "grant", "funder_scheme": "Student Elective", "start_date": "2008-06-07", "end_date": "2008-09-06", "start_year": 2008, "end_year": 2008, "landing_page_url": "https://wellcome.org/grant-funding/people-and-projects/grants-awarded?q=360G-Wellcome-087287_Z_08_Z", "doi": null, "provenance": "wellcome_trust", "lead_investigator": {"given_name": "Mr Prashen", "family_name": "Pillay", "orcid": null, "role_start": null, "affiliation": {"name": "Newcastle University", "country": "United Kingdom", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087492974", "display_name": "Architecture in Austria since 1968", "description": null, "funder_award_id": "P15887", "funder": {"id": "https://openalex.org/F4320321181", "display_name": "Austrian Science Fund", "doi": "10.13039/501100002428"}, "amount": 87291.8, "currency": "EUR", "funding_type": "grant", "funder_scheme": null, "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://www.fwf.ac.at/en/research-radar/10.55776/P15887", "doi": "http://dx.doi.org/10.55776/p15887", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087493074", "display_name": "BRCA1 TESTING IN A LARGE AFRICAN AMERICAN KINDRED", "description": null, "funder_award_id": "5r01hg002241-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 388655.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2000-09-25", "end_date": "2004-06-30", "start_year": 2000, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6536479", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANITA Y", "family_name": "KINNEY", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF UTAH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087493150", "display_name": "HERPETIC STROMAL KERATITIS PATHOGENESIS: AN ANIMAL MODEL", "description": null, "funder_award_id": "1f32ey006505-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "1993-12-25", "end_date": null, "start_year": 1993, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/2160355", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DONNA M", "family_name": "BOULEY", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TENNESSEE KNOXVILLE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408749433", "display_name": "\"Gott ist Richter unter den Göttern\" (Ps 82,1b): Mono, Polytheismus, die Ontologie der Teilhabe im Platonismus und Christentum, die Henaden bei Proklos und der interreligiöse Dialog bei Cusanus ApuleiusRezeption in C.S. Lewis' Till We Have Faces Augustins Hermeneutik in De Genesi ad litteram", "description": "Das Ziel des Heisenberg-Programms ist es, herausragenden Wissenschaftlerinnen und Wissenschaftlern, die alle Voraussetzungen für die Berufung auf eine Langzeit-Professur erfüllen, zu ermöglichen, sich auf eine wissenschaftliche Leitungsfunktion vorzubereiten und in dieser Zeit weiterführende Forschungsthemen zu bearbeiten. In der Verfolgung dieses Ziels müssen nicht immer projektförmige Vorgehensweisen gewählt und realisiert werden. Aus diesem Grunde wird bei der Antragstellung und auch später bei der Abfassung von Abschlussberichten - anders als bei anderen Förderinstrumenten - keine \"Zusammenfassung\" von Projektbeschreibungen und Projektergebnissen verlangt. Somit werden solche Informationen auch in GEPRIS nicht zur Verfügung gestellt.", "funder_award_id": "232281448", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 769591.6576, "currency": "EUR", "funding_type": "fellowship", "funder_scheme": "Heisenberg-Stipendien", "start_date": "2013-01-01", "end_date": "2020-12-31", "start_year": 2013, "end_year": 2020, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/232281448", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087494338", "display_name": "Studies on the creation of new type silk obtained from new cocoons differ sericin content and dilament size from conventional cocoons.", "description": "The silk worm races which are different in denier, length of cocoon filament, degumming loss percentage from conventional silk worm races were breeded and the physical properties of the silk worm cocoon filaments obtained from these races were investigated. Further, the various properties of fine structures, mechanical properties, endowed effect of shrinkage, dyeing and chemical treatments were investigated. Results obtained were as follows; the cocoon length of fine size cocoons had 1000 m and the filament size showed value 1.5 d. In the coarse size cocoons, length and size showed value 700 m, 4.50 d respectively. In the cocoons a smaller sericin content, the degumming loss percentage showed value 22%. The raw silks obtained from the cocoons which have a smaller size showed a negative correlation between strength and elongation in the tensile properties and the empty holes of the cross section at the breaking point were prr. contrary to this the raw silks obtained from the cocoons which are a larger size showed a positive correlation in the tensile properties and the empty holes were rich. Among the raw silks obtained from these cocoons, the raw silk obtained from the cocoons containing a smaller sericin content showed low value of Young's modulus, large endowed effect of shrinkage, and the stability of shrinkage. Synthetically, examining these effect, it was found that the cocoons containing a smaller sericin content were favorable for the knitting materials.", "funder_award_id": "61480051", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 6200000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480051/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Kitamura", "family_name": "AIO", "orcid": null, "role_start": null, "affiliation": {"name": "Faculty of Technology, Tokyo University of Agriculture and Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020015001", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087495763", "display_name": "THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF TTO IN THE AMOUNT OF 430,408 ON CONTRACT HR0011-18-2-0028.", "description": "THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH IN SUPPORT OF TTO IN THE AMOUNT OF 430,408 ON CONTRACT HR0011-18-2-0028.", "funder_award_id": "HR00111820028", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 404528.52, "currency": "USD", "funding_type": "grant", "funder_scheme": "RESEARCH AND TECHNOLOGY DEVELOPMENT", "start_date": "2018-03-16", "end_date": "2018-09-17", "start_year": 2018, "end_year": 2018, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_HR00111820028_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087496796", "display_name": "Erforschung der Zusammenhänge zwischen externer Verspannung und Generation tiefer Zentren in Halbleiterstrukturen von DiodenLaserbauelementen", "description": "Keine Zusammenfassung vorhanden", "funder_award_id": "5228382", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 1099416.6538000002, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "1999-01-01", "end_date": "2004-12-31", "start_year": 1999, "end_year": 2004, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/5228382", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087498051", "display_name": "生殖の形態変化に関する歴史社会学的研究", "description": "今年度の研究活動においては、「新しい生殖技術」研究の前提をなす作業の一環として、妊娠中絶をめぐる倫理的・社会的問題について考察を深めることに主眼をおいた。これは1991年に発表した拙論「女性の自己決定権の擁護」に対して、新たな視点からの反論が加えられたことを受け、その誤解をただし、生殖技術全般に関する議論につきものの陥穽をあらかじめ明らかにしておく目的で行われたことである。具体的には、(1)受精の瞬間=生命権の「主体」たる「人間」の成立、という発生観の恣意性、(2)妊娠中絶に関わる判例における「期間規定」「適応規定」という二分法の不徹底性、(3)生殖倫理に関わる男女の権利の非対称性、(4)技術水準による「倫理」の絶対的被制約性、等を主要な論点とし、旧論を補強した。この論を構築する過程で、胎児を受精の瞬間から生命権の主体として認めるプロ・ライフ的論理の根底的な曖昧さと政治性とがより明らかになった。さらに今後の展開に資する点としては、法学的議論において、女性の自己決定権がしばしばJ・ロック以来の「自己身体の自己所有権」という論理の延長上で語られることの不十分さを浮かび上がらせることができたと言える。すなわち、1960年代以降の新しい女性開放運動が主張し、近年では女性の「生殖に関わる健康と諸権利」という思想に結実してきた内容は、身体の自己所有ではなくむしろそうした発想が前提としてきた心身観を見直し、所有とは異なるあり方として自己/身体の存在を捉え直そうという提言をその核心においているということが明確に認識されたのである。これは今後、胎児のみならず受精卵や生殖細胞の倫理的地位を考えるにあたっても、所有論を超える人権論の構想の原点として、極めて重い意義を持つ論点であろう。", "funder_award_id": "06710132", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1994-04-01", "end_date": "1994-03-31", "start_year": 1994, "end_year": 1994, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06710132/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "秀一", "family_name": "加藤", "orcid": null, "role_start": null, "affiliation": {"name": "Meiji Gakuin University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000247149", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087504080", "display_name": "Ticino Ducale", "description": null, "funder_award_id": "67432", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 10000.0, "currency": "CHF", "funding_type": "grant", "funder_scheme": "Publication grants", "start_date": "2002-03-01", "end_date": "2002-03-31", "start_year": 2002, "end_year": 2002, "landing_page_url": "https://data.snf.ch/grants/grant/67432", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Divisione della Cultura Dipartimento dell'istruzione e della cultura del Cantone", "family_name": "Ticino", "orcid": null, "role_start": null, "affiliation": {"name": "Unassignable – NA", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087505677", "display_name": "Unconditional tabulation of class groups of real quadratic fields", "description": "No summary - Aucun sommaire", "funder_award_id": "352930-2007", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4500.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "University Undergraduate Student Research Awards", "start_date": "2007-04-01", "end_date": "2008-03-31", "start_year": 2007, "end_year": 2007, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=352930-2007", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Jeffrey", "family_name": "Nguyen", "orcid": null, "role_start": null, "affiliation": {"name": "University of Calgary", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087509007", "display_name": "Archival description as rhetorical genre in traditional and web-based environments", "description": null, "funder_award_id": "10849", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 113040.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Standard Research Grants", "start_date": "2009-04-01", "end_date": null, "start_year": 2009, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "MacNeil, Heather M.", "orcid": null, "role_start": null, "affiliation": {"name": "University of Toronto", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408750987", "display_name": "Enhancement of a Research-Based Curriculum Through Microscopy and Imaging", "description": "Recent progress toward a research-based curriculum in geology emphasizes the use of optical microscopy and the interaction of electromagnetic radiation with matter in the study of geological problems. This project enhances these curricular changes with the implementation of a research-grade petrographic microscope that includes 35-mm photography and video capabilities. Improvements resulting from this project include enhanced demonstration capabilities throughout the course curriculum; greater comprehension of scientific methods and principles by non-science-majors and potential science majors in introductory courses; the exposure of undergraduate majors to modern petrographic techniques that previously were not possible; and the enhancement of independent research projects. The microscope and video/photographic system makes the study of rocks and minerals more appealing to non-science-majors and facilitates the application of rock and mineral studies as a means to understanding the composition and evolution of the Earth, environmental problems, and the origin and evolution of life in introductory courses. Use of the imaging capabilities to demonstrate optical techniques to students in Mineralogy enhances the comprehension of optics theory and techniques resulting in increased student use of optical methods as investigative tools later in the course and in other upper-level courses. The microscope/imaging system is also being used to involve students in interactive laboratory projects in courses in mineralogy, petrology, structural geology, economic geology, sedimentology, and paleontology. Finally, the research-grade petrographic microscope with modern imaging capabilities enhances the quality of undergraduate research publications, presentations, and reports resulting from independent projects, honors projects, and senior capstone projects that are now required for graduation.", "funder_award_id": "9552222", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 19364.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1995-09-01", "end_date": "1997-08-31", "start_year": 1995, "end_year": 1997, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9552222", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Karl", "family_name": "Wirth", "orcid": null, "role_start": null, "affiliation": {"name": "Macalester College", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087514045", "display_name": "CYTOCHEMISTRY OF CENTRAL AUDITORY PATHWAYS", "description": null, "funder_award_id": "1r01dc000726-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1990-03-01", "end_date": "1993-02-28", "start_year": 1990, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3217411", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RICHARD L", "family_name": "SAINT MARIE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CONNECTICUT SCH OF MED/DNT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087516355", "display_name": "EAGER: Functional Integration of Synthetic Kinases into Endogenous Signaling Networks", "description": "Cells can acquire new genes by natural mechanisms (e.g. horizontal gene transfer) or by artificial means (e.g. genetic engineering). We are beginning to understand how newly-acquired genes are integrated into the host's genome, but the evolutionary mechanisms by which the proteins produced by these genes become functionally incorporated into the cell's regulatory networks remain largely unknown. In this project, synthetic biology and directed evolution approaches will be used to recreate and analyze in the laboratory this network rewiring process. Using yeast that have been engineered with signaling modules taken from the mammalian mitogen-activated protein kinase cascade, evolutionary strategies will be applied in the laboratory to reward individual yeast cells that acquire mutations resulting in functional utilization of these introduced mammalian proteins. During this selection process, genome sequencing will be performed to characterize the mutations that occur and to reconstruct the evolutionary processes that result in functional rewiring of the host's signaling networks. \r\n\r\nBroader Impacts: The scientific principles underlying this research will be used to train graduate and undergraduate students, including those from underrepresented minorities. Modules on evolution in synthetic biology will be added to an undergraduate course taught by the principal investigator. Undergraduates will also have the opportunity to learn about synthetic biology through the International Genetically Engineered Machine (iGEM) competition. Additional outreach will be targeted to high school teachers and high school students through summer training programs. The insights gained from this project will have relevance for understanding the emergence of antibiotic resistance in microbes, the cultivation and properties of genetically modified crops, and the design of novel synthetic biology devices.", "funder_award_id": "1414482", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 156650.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2013-06-30", "end_date": "2015-10-31", "start_year": 2013, "end_year": 2015, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414482", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Casim", "family_name": "Sarkar", "orcid": null, "role_start": null, "affiliation": {"name": "University of Minnesota-Twin Cities", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087518103", "display_name": "PheBC: bias correction methods for EHR derived phenotype", "description": "Project Narrative Data derived from electronic health records (EHR) provide tremendous opportunities for clinical and translational research. A key challenge remains that the reproducibility of findings across studies is limited, which raised a fundamental concern on the value of these researching findings. The overarching goal of this proposal is to develop a rigorous bias correction tool through modern knowledge engineering and data-driven statistical modeling, for enhancing the reproducibility of EHR-based clinical findings.", "funder_award_id": "5r01lm013519-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 342180.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2021-09-01", "end_date": "2026-05-31", "start_year": 2021, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10840905", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "YONG", "family_name": "CHEN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087519614", "display_name": "Paläoumwelt und Klimarekonstruktion in der Winterregenzone Südafrikas mit Hilfe integrierter Untersuchungen lakustriner und mariner Archive", "description": "Der globale Klimawandel beeinträchtigt die derzeitige Wasserverfügbarkeit in vielen semi-ariden und ariden Gebieten der Welt, wie beispielsweise im südlichen Afrika. Für präzise Vorhersagen zukünftiger Veränderungen des regionalen Wasserhaushaltes und des regionalen Klimas ist es notwendig sowohl die Steuerungsfaktoren für Umwelt- und Klimaveränderungen der Vergangenheit als auch deren räumliche und zeitliche Variationen zu identifizieren. Das angestrebte Forschungsprojekt wird einen Beitrag zum Verständnis der Holozänen Umwelt- und Klimavariabilität in der Winterregenzone Südafrikas leisten.Innerhalb des beantragten Projektes sollen Paläoumwelt-, Paläoklima-, und Meeresspiegelveränderungen mit Hilfe eines Multi-Proxy Ansatzes hoch-auflösend rekonstruiert werden. Die Basis hierfür bilden geochemische, mineralogische und bio-geochemische Untersuchungen eines bereits geborgenen 13,65 m langen Seesedimentkernes aus dem Küstensee Verlorenvlei, der die letzten 9000 cal BP abdeckt. Vergleichbare Daten aus Untersuchungen eines marinen Sedimentkernes, vom Bereich vor der Küste des Verlorenvleis, werden von Projektpartnern geliefert. Der Vergleich beider Archive soll Veränderungen bestimmter Parameter während des Transportes vom Land zum Ozean aufklären, und dabei helfen, eindeutige Klimasignale abzuleiten. Neben der Untersuchung der natürlichen Klimavariabilität sollen die Untersuchungen der Seesedimente des Weiteren neue Informationen zum menschlichen Einfluss auf die Umwelt erbringen. Aus den übrigen beiden Niederschlagszonen Südafrikas (Übergangs- und Sommerregenzone) werden ebenfalls aus Untersuchungen von lakustrinen und marinen Archiven durch Projektpartner Datensätze geliefert. Diese werden im Rahmen des sogenannten RAIN-Projektes, gefördert durch das Bundesministerium für Bildung und Forschung (BMBF), erhoben, zu dem das hier beantragte Projekt assoziiert werden soll. Dies wird die Rekonstruktion der Dynamik der drei Niederschlagszonen in Südafrika während des Holozäns ermöglichen. Die Identifikation der raum-zeitlichen Veränderungen der Steuerungsfaktoren regionaler Umweltveränderungen wird ebenfalls zum Verständnis der globalen Klimadynamik beitragen können.", "funder_award_id": "282806576", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 329824.9961, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "2015-01-01", "end_date": "2018-12-31", "start_year": 2015, "end_year": 2018, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/282806576", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087522328", "display_name": "Cyclic nucleotide phosphodiesterase regulation in vascular calcification", "description": "PROJECT NARRATIVE Calcification that develops in leg arteries of patients with diabetes, chronic kidney disease, and peripheral artery disease is strongly associated with increased cardiovascular morbidity and mortality. This proposal seeks to demonstrate that a specific enzyme, the phosphodiesterase 10A (PDE10A), plays a crucial role in vascular calcification by regulating p38-MAPK-MMP-3 signaling. Our goal is to target PDE10A as a novel therapeutic strategy to reduce medial artery calcification and prevent amputation in our patients.", "funder_award_id": "1r01hl157111-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 653096.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2022-06-15", "end_date": "2026-05-31", "start_year": 2022, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10521675", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "YUJUN", "family_name": "CAI", "orcid": null, "role_start": null, "affiliation": {"name": "YALE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087522670", "display_name": "Mechanism of PAI-1 Polarization to Myoendothelial Junctions", "description": " Metabolic syndrome is prevalent in over 50% of the American population, which if left untreated, can lead to severe cardiovascular diseases, such as hypertension and type II diabetes. However, there is currently no known therapeutic treatment. It is known that the protein plasminogen activator inhibitor- 1 (PAI-1) is always prevalent in high concentrations in the circulation as metabolic syndrome progresses and recent work by our laboratory has indicated that PAI-1 can be found in a very specialized location in the walls of blood vessels, the myoendothelial junction. Our grant proposes to dissect the mechanisms whereby PAI-1 is localized to the myoendothelial junction in hopes of understanding how PAI-1 may contribute to, or exacerbate, metabolic syndrome in the vasculature. Successful completion of this proposal could lead to novel therapeutic targets for treatment of metabolic syndrome. ", "funder_award_id": "1r21hl107963-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 231000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2012-01-15", "end_date": "2013-12-31", "start_year": 2012, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8240123", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BRANT E", "family_name": "ISAKSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF VIRGINIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408752402", "display_name": "鼻腔内一酸化窒素(NO)の鼻腔通気に対する影響の研究", "description": "運動負荷前後の鼻腔通気度と鼻腔産生NOを同時に計測し、その関係を検討した。鼻副鼻腔疾患を有さない健康成人男子を対象とした。運動負荷前後の鼻腔通気度と鼻腔産生NO量を同時に測定し、比較検討した。1.運動負荷30分間の安静により室内環境に適応させた後、トレッドミルを用いて傾斜10°、速度6km、時間4分間の運動負荷を与えた。2.鼻腔通気度の測定前鼻誘導法により測定した。100Paにおける両側の抵抗値(Pa/cm^3/min)およびパーセント表示で表した。3.鼻腔産生NO量の測定小型のポンプを用いて一側の外鼻孔にチューブを装着し、15秒間換気し250mlのガスを収集しNO濃度既知のガス2000mlで希釈してNOアナライザーにより測定した。得られた結果を単位時間あたりのNO産生量として表した(nL/min)。測定の際には被験者の頬を膨らませ、口腔内の圧を上昇させ鼻腔を下気道から遮断された腔として下気道からの呼気ガスに影響されない状態とした。『結果』 いずれの被験者においても運動負荷後、鼻腔通気度は改善し、鼻腔産生NO量は減少した。運動負荷により通気度は0.27±0.04から0.17±0.04に改善し、鼻腔産生NO量は323±91から229±63に減少した。両者は運動負荷前後おいて統計学的に有意な変化を示した。以上より運動負荷後の鼻腔通気度改善時に、測定した鼻腔産生NO量が減少したことは、鼻腔通気度の変化にNOが関与している可能性があると考えられた。", "funder_award_id": "07771421", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1000000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1995-04-01", "end_date": "1995-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07771421/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "吉史", "family_name": "小林", "orcid": null, "role_start": null, "affiliation": {"name": "Asahikawa Medical College", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070225556", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087525635", "display_name": "Les suretes reelles en changement : l'analyse de l'actualite et son avenir", "description": "At the beginning of 21th century, Japan and France have revised the civil law, what is called the real securitys, les suretes reelles in French. This study intended to analyze the situation of two laws, and to clarify some changes in common and some differences. We can have a perspective on future with our works.", "funder_award_id": "15K03196", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4030000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2015-04-01", "end_date": "2019-03-31", "start_year": 2015, "end_year": 2019, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K03196/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yoichi", "family_name": "IMAMURA", "orcid": null, "role_start": null, "affiliation": {"name": "Yokohama National University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030160063", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087528342", "display_name": "心身障害児特に視力障害児・聴力障害児の性行動に関する実態調査とその指導法に関する研究", "description": "Principal Investigator：黒川 義和, Project Period (FY)：1977, Research Category：Grant-in-Aid for Encouragement of Young Scientists (B), Research Field：教育学", "funder_award_id": "290738", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 150000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (B)", "start_date": "1977-04-01", "end_date": "1977-03-31", "start_year": 1977, "end_year": 1977, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X00220----290738/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087528381", "display_name": "ドライアッシュ式ジェット噴流層石炭ガス化装置の開発に関する基礎研究", "description": "本年度は, ベンチスケールの一塔二段粒子層方式のガス化装置を作成して酸素分割供給法で太平洋炭のガス化実験をおこない, 以下の成果を得た. 1.ジェット噴流層の流動特性を詳細にしらべ(1)噴流部における粒子の上昇速度はガス流速の増加によって顕著に増加するが, 環状部における粒子の下降速度の変化は比較的小さいこと, (2)粒子の質量流束(flux)はガス流速の増加とともに層半径方向へ広がった分布を示し, 層中心付近の上昇粒子の流束は減少すること, (3)粒子の質量循環速度はノズル径や静止時の粒子層高に依存せず, ガス流速に比例して増加すること, (4)層の空間率は噴流部の方がその外側の環状部の値より小さく, 通常型噴流層での結果とは逆の傾向を示すことなどを明らかにした.2.小型固定層装置でガス化速度に及ぼすCO_2とCOの分圧の影響をしらべ, 速度式は吸着項を含むL-H型速度式で精度よく表現できることを認めた.3.太平洋炭のガス化実験では, 従来のドライアッシュ方式のガス化炉で困難とされている1000°C以上の高温でも, 本方式のガス化炉はクリンカートラブルなしに操作が可能であることを確認した. ガス化成績に及ぼす操作条件の影響に関しては, ガス化温度900〜1180°Cの条件で炭素転化率75〜80%, 冷ガス熱効率70〜75%, 水蒸気分解率20〜30%を得, 酸素比がガス化成績に最も大きな影響を及ぼすことを明らかにした. 生成ガスの組成は水素38〜45%, 一酸化炭素25〜29%, 炭酸ガス22〜28%, メタン3%で, その総発熱量は11〔MJ/m^3〕であった.以上の結果より, 本研究で開発したガス化炉ではガス化反応の高温化によって炭素転化率と生成ガス品位の向上が達成できることおよびガス化炉フリーボード部の改良で未反応炭素の飛び出し量の低減をはかれば反応成績をさらに向上させ得るとの結論を得た.", "funder_award_id": "62603503", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2700000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research on Priority Areas", "start_date": "1987-04-01", "end_date": "1987-03-31", "start_year": 1987, "end_year": 1987, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62603503/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "修", "family_name": "上牧", "orcid": null, "role_start": null, "affiliation": {"name": "Hokkaido University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050001285", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087531350", "display_name": "Unshielded quantitative imaging of magnetic nanoparticles", "description": null, "funder_award_id": "PAT 7880823", "funder": {"id": "https://openalex.org/F4320321181", "display_name": "Austrian Science Fund", "doi": "10.13039/501100002428"}, "amount": 444816.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": null, "start_date": "2025-04-01", "end_date": "2029-03-31", "start_year": 2025, "end_year": 2029, "landing_page_url": "https://fwf.ac.at/forschungsradar/10.55776/PAT7880823", "doi": "10.55776/pat7880823", "provenance": "openaire_fwf", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087532783", "display_name": "UNDERSTANDING SUPRATHRESHOLD HEARING DEFICITS", "description": "PROJECT NARRATIVE The purpose of this research program is to improve our understanding of suprathreshold hearing deficits and to establish a theoretical framework for the development of diagnostic methods for hidden hearing loss in humans. The work addresses issues that have both basic scientific interest and applied clinical relevance. The work will improve our understanding of potential mechanisms underlying hearing and listening difficulties. The ability to diagnose hidden hearing loss in the clinic will usher in new methods for clinical evaluation and may lead to advances in intervention strategies for individuals who have hidden hearing loss. Therefore, the proposed research is relevant to public health because it applies scientific knowledge to address the effects of hearing loss, which affects more than 30 million people in the US.", "funder_award_id": "5r01dc016348-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 406542.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2017-09-21", "end_date": "2022-08-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9995454", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEPHEN T", "family_name": "NEELY", "orcid": null, "role_start": null, "affiliation": {"name": "FATHER FLANAGAN'S BOYS' HOME", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087535636", "display_name": "Collaborative Research: Wave driven flow through a shallow, fringing reef", "description": "Coral reefs face two significant long-term challenges to their existence: (1) Ocean acidification, which hinders the ability of corals to calcify; and (2) Ocean warming, which leads to coral bleaching. The Ofu reef (American Samoa), home to corals that seem to have exceptional bleaching resistance, is the location of active research into how corals may be able to meet those challenges biologically and biogeochemically. Given that both carbon system and temperature dynamics on the reef depend on flow, the physical insights and quantitative results from the data and modeling of this study should provide significant input to studies of ecology and biogeochemistry at Ofu and other similar reefs. In addition, the project will advance the technology for mapping reefs at high resolution. The project will involve several undergraduate and graduate students, as well as a postdoctoral scientist, providing unique material for university courses. The results of this study will be brought to the general public through a series of short online videos, produced to explain the link between hydrodynamic processes and reef health.\r\n\r\nThe goals of this project are: (1) Test the concept that the relative importance of friction in the lagoon and friction on the reef crest determines the structure of the overall circulation; (2) Test the hypothesis that drag coefficients related to local, spatially averaged, flows can be estimated from data on reef topography; (3) Carry out a quantitative evaluation of the dynamics of Ofu reef flows using a depth-averaged circulation model based on detailed bathymetry and estimates of spatially variable drag parameterizations. The primary activities of this project would be: (a) Mapping of reef bathymetry at decimeter scale using an Unmanned Aerial Vehicle carrying cameras and novel image processing of the resulting images; (b) Deploying a set pressure loggers, temperature loggers, acoustic Doppler current profilers and a meteorological station for a 2-km long section of the Ofu reef for two one-month periods and analyzing the results of these observations to estimate flow properties such as drag; (c) Idealized and realistic modeling studies carried out using a three dimensional model. The design of the instrument array in combination with the mapping and modeling is intended to both test the conceptual circulation model and to evaluate how drag on different parts of the reef varies with overall depth, flow and with geometric parameters describing the physical structure of the reef.", "funder_award_id": "1536618", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 302588.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2015-10-01", "end_date": "2019-09-30", "start_year": 2015, "end_year": 2019, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1536618", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Clifton", "family_name": "Woodson", "orcid": null, "role_start": null, "affiliation": {"name": "UGA--Athens Campus", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087538581", "display_name": "Genetic dissection of endoplasmic reticulum stress in POMC neurons", "description": " Project Narrative The proposed studies will greatly increase our understanding of the mechanisms underlying leptin and insulin resistance and obesity. The study findings will provide valuble information with which to develop treatment strategies for the prevention of obesity and diabetes.", "funder_award_id": "5k01dk087780-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 118829.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K01", "start_date": "2010-04-01", "end_date": "2013-03-31", "start_year": 2010, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8046381", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KEVIN W", "family_name": "WILLIAMS", "orcid": null, "role_start": null, "affiliation": {"name": "UT SOUTHWESTERN MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087539522", "display_name": "AL NATIONAL GUARD MASTER COOPERATIVE AGREEMENT AIR NG FIRE PROTECTION ACTIVITIES APPENDIX 1024B", "description": "AL NATIONAL GUARD MASTER COOPERATIVE AGREEMENT AIR NG FIRE PROTECTION ACTIVITIES APPENDIX 1024B", "funder_award_id": "W912JA102024B", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 3221560.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "NATIONAL GUARD MILITARY OPERATIONS AND MAINTENANCE (O&M) PROJECTS", "start_date": "2013-10-01", "end_date": "2014-09-30", "start_year": 2013, "end_year": 2014, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_W912JA102024B_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087543328", "display_name": "Literary portrayals of domestic violence in early modern England", "description": null, "funder_award_id": "32737", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 17500.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Graduate Scholarships Program - Masters Scholarships", "start_date": "2005-04-01", "end_date": null, "start_year": 2005, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Toron, Alison R.", "orcid": null, "role_start": null, "affiliation": {"name": "York University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087543639", "display_name": "Tomorrow I was always a lion: Investigating psychosis and recovery", "description": "Through a creative collaboration between Belarus Free Theatre (BFT), scientific consultants (including Kings College IoPPN and Institute of Neuroscience Trinity College Dublin), and clinical practitioners working with young people, BFT will create a new theatrical and digital production based on the memoir ‘A Road Back from Schizophrenia’ by Norwegian psychologist Arnhild Lauveng. By bringing together contributors from across disciplines into the creative team, the project aims to advance understanding and examine a range of different questions raised by the memoir, including (i) the nature of \"recovery\" from schizophrenia vs. managing and living with the condition, (ii) The factors that impact vulnerability to psychosis and recovery, (iii) The interplay between genetic factors and environmental conditions in the manifestation of psychosis, (iv) Social and cultural explanations and interpretations of disease and how they affect stigma. Contributions from scientific contributors will be incorporated into the production. Through collaboration with Young Minds (NGO partner) and performance runs in The Albany Theatre (London), Kings/Falmouth University, Contact Theatre (Manchester). BFT will engage diverse audience in dialogue about the nature of mental illness, recovery, and social interpretations. Post-show workshops and discussions will continue to feed into the learnings from the project.", "funder_award_id": "201015", "funder": {"id": "https://openalex.org/F4320311904", "display_name": "Wellcome Trust", "doi": "10.13039/100010269"}, "amount": 39084.0, "currency": "GBP", "funding_type": "grant", "funder_scheme": "Public Engagement", "start_date": "2016-03-02", "end_date": "2017-03-01", "start_year": 2016, "end_year": 2017, "landing_page_url": "https://europepmc.org/grantfinder/grantdetails?query=pi:\"%7BProf%7D%7BDazzan%7D%7BPaola%7D%7BP%7D\" gid:\"201015\" ga:\"Wellcome Trust\"", "doi": "https://doi.org/10.35802/201015", "provenance": "crossref_work", "lead_investigator": {"given_name": "Natalia", "family_name": "Kaliada", "orcid": null, "role_start": null, "affiliation": {"name": "IND Natalia Kaliada 83974", "country": null, "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087544110", "display_name": "Interplay between the Mtb electron transport chain and carbon metabolism", "description": "There is strong interest in developing drug compounds that target and disrupt oxidative phosphorylation (OXPHOS) as a means to kill Mycobacterium tuberculosis (Mtb), the etiological agent of TB disease. Despite the recent development of anti-TB drugs that target the Mtb electron transport chain (ETC), it is currently unknown how inhibition of respiratory complexes in the ETC leads to efficient cell killing. In this proposal, we will test the hypothesis that interplay exits between the Mtb ETC and central carbon catabolism that prevents effective killing by anti-TB drugs.", "funder_award_id": "1r01ai137043-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 458227.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2018-11-07", "end_date": "2023-10-31", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/9660045", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ADRIE JC", "family_name": "STEYN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ALABAMA AT BIRMINGHAM", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087547858", "display_name": "INVESTIGATION OF ADVANCED COMPOSITE MATERIALS AND AUTOMATED PROCESS", "description": "INVESTIGATION OF ADVANCED COMPOSITE MATERIALS AND AUTOMATED PROCESS", "funder_award_id": "NCC1227", "funder": {"id": "https://openalex.org/F4320306101", "display_name": "National Aeronautics and Space Administration", "doi": "10.13039/100000104"}, "amount": -9068.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "RESEARCH GRANTS FOR THE SPACE PROGRAM", "start_date": "2001-03-29", "end_date": "2001-04-10", "start_year": 2001, "end_year": 2001, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_NCC1227_080/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G40875499", "display_name": "ZINC FINGER TRANSCRIPTION FACTORS IN KIDNEY DEVELOPMENT", "description": null, "funder_award_id": "5r01dk045617-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1992-09-30", "end_date": "1997-09-29", "start_year": 1992, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/2144830", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "VIKAS P", "family_name": "SUKHATME", "orcid": null, "role_start": null, "affiliation": {"name": "BETH ISRAEL DEACONESS MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40875502", "display_name": "Vaccine-enhanced respiratory syncytial virus disease", "description": null, "funder_award_id": "1r01ai054952-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 365625.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2005-03-15", "end_date": "2010-02-28", "start_year": 2005, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/6925300", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "FERNANDO P", "family_name": "POLACK", "orcid": null, "role_start": null, "affiliation": {"name": "JOHNS HOPKINS UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087552177", "display_name": "RADIOLOGICAL DIAGNOSTIC ONCOLOGY GROUP 11", "description": null, "funder_award_id": "3u01ca045256-04s2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "1987-09-04", "end_date": "1993-07-31", "start_year": 1987, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3548991", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BARBARA J", "family_name": "MCNEIL", "orcid": null, "role_start": null, "affiliation": {"name": "AMERICAN COLLEGE OF RADIOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087552402", "display_name": "Chemical Approaches to Mapping Cell Signaling Pathways", "description": "PUBLIC HEALTH RELEVANCE: Kinase and phosphatase enzymes are involved in various diseases and are the target of multiple pharmaceutical drugs. The application outlines new chemical approaches to characterizing kinase and phosphatase substrates to aid in the understanding of disease and development of new treatments.", "funder_award_id": "5r01gm079529-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 280716.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-06-01", "end_date": "2019-07-31", "start_year": 2009, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/9321853", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY KAY H", "family_name": "PFLUM", "orcid": null, "role_start": null, "affiliation": {"name": "WAYNE STATE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087554384", "display_name": "Development of measuring system for charge distribution", "description": "A system for visualizing the electrostatic charge without contact using charged material oscillation method has been developed. There, it was established a technology to convert the information of the charge from an electric field, and a focused ultrasoun", "funder_award_id": "23760377", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4420000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23760377/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Kazuya", "family_name": "KIKUNAGA", "orcid": null, "role_start": null, "affiliation": {"name": "National Institute of Advanced Industrial Science and Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010581283", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087555371", "display_name": "Concentracao serica de igc de cabritos recem nascidos alimentados com colostro de cabras submetido ou nao a tratamento termico e com colostro de vacas.", "description": null, "funder_award_id": "06/54909-6", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Exterior", "start_date": "2006-10-15", "end_date": "2006-10-19", "start_year": 2006, "end_year": 2006, "landing_page_url": "https://bv.fapesp.br/en/auxilios/06-54909-6/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "José", "family_name": "Jurandir Fagliari", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087555481", "display_name": "Summer Institute for College Teachers in Mathematics", "description": null, "funder_award_id": "69y5445", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1969-01-01", "end_date": "1970-01-01", "start_year": 1969, "end_year": 1970, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=69Y5445", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087557704", "display_name": "MOLECULAR VIROLOGY", "description": null, "funder_award_id": "3p01ca023767-14s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "program", "funder_scheme": "P01", "start_date": "1978-12-01", "end_date": "1993-07-31", "start_year": 1978, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3093075", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RICHARD", "family_name": "AXEL", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIV NEW YORK MORNINGSIDE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408755967", "display_name": "MATERIALS SCIENCE OF ELECTRODES AND INTERFACES FOR HIGH PERFORMANCE ORGANIC PHOTOVOLTAICS", "description": "MATERIALS SCIENCE OF ELECTRODES AND INTERFACES FOR HIGH PERFORMANCE ORGANIC PHOTOVOLTAICS", "funder_award_id": "FG02-08ER46536", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 1733334.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "OFFICE OF SCIENCE FINANCIAL ASSISTANCE PROGRAM", "start_date": "2008-09-13", "end_date": "2014-12-31", "start_year": 2008, "end_year": 2014, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_FG02-08ER46536_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087567505", "display_name": "無麻酔高血圧ラットの末梢血管抵抗の研究", "description": "Principal Investigator：入内島 十郎, Project Period (FY)：1984 – 1985, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：General physiology", "funder_award_id": "59570037", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1400000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59570037/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087568633", "display_name": "対人認知における先行経験の暗黙裡の影響について", "description": "Principal Investigator：池上 知子, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Psychology", "funder_award_id": "02710045", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1990-04-01", "end_date": "1990-03-31", "start_year": 1990, "end_year": 1990, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02710045/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087568823", "display_name": "An Ideological and Historical Study of the Cybernetics Movement", "description": "本研究は以下の三つの問いによって構成される。①サイバネティックスとは何であったのか？②サイバネティックス運動の進展の中で「情報的世界観」が如何なる理路で形成されてきたか？③現在の情報社会は「情報的世界観」を、その社会構造にどのような形で思想的に組み込んでいるのか？「サイバネティックス」を、ウィーナー思想のみならず、彼に影響を受けた第二世代によって20世紀いっぱいに渡って展開された諸思潮も含む「サイバネティックス運動」として捉え返し、その生成から「情報的世界観」の形成、様々な分野でのその適用迄を系統的に跡付け、運動の全貌を科学・技術思想史的なパースペクティヴから解明する。", "funder_award_id": "22K00112", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2470000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2022-04-01", "end_date": "2027-03-31", "start_year": 2022, "end_year": 2027, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K00112/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "岳彦", "family_name": "大黒", "orcid": null, "role_start": null, "affiliation": {"name": "Meiji University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030369441", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087569270", "display_name": "Modulation of fibronectin to improve integration of dental implant materials", "description": null, "funder_award_id": "5r01de017695-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 428872.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2007-08-01", "end_date": "2012-06-30", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7467957", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DANIEL E", "family_name": "MACDONALD", "orcid": null, "role_start": null, "affiliation": {"name": "HOSPITAL FOR SPECIAL SURGERY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087569436", "display_name": "26th Dynamic Econometrics Conference", "description": null, "funder_award_id": "24/03246-5", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Exterior", "start_date": "2024-04-03", "end_date": "2024-04-05", "start_year": 2024, "end_year": 2024, "landing_page_url": "https://bv.fapesp.br/en/auxilios/24-03246-5/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Emerson", "family_name": "Fernandes Marçal", "orcid": null, "role_start": null, "affiliation": {"name": "Fundação Getúlio Vargas (FGV). Escola de Economia de São Paulo (EESP)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087569526", "display_name": "Laser Aided Direct Metal Deposition Deposition of Three- Dimensional Components With Controlled Dimension, Microstructure and Mechanical Properties", "description": "Rapid prototyping by curing polymers with laser light has created considerable interests in industry to generate three dimensional parts directly from Computer Aided Design (CAD) drawings to aid design processes. Laser cladding by layers offers the possibility of fabrication of 100% dense metal component. The objective of this research is to develop a Laser Aided Metal Deposition System (LAMDS) capable of forming near 100% dense three-dimensional objects directly from CAD drawing. The project will develop a fundamental understanding between the process parameters for laser aided metal deposition of H13 steel with deposit dimension with 10-100 micron accuracy, microstructure and mechanical properties. The research project has a balance between theory and experiment, and will provide valuable findings for the tools and dies manufacturing industry.", "funder_award_id": "9700007", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 297140.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1997-08-01", "end_date": "2001-07-31", "start_year": 1997, "end_year": 2001, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9700007", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Jyotirmoy", "family_name": "Mazumder", "orcid": null, "role_start": null, "affiliation": {"name": "Regents of the University of Michigan - Ann Arbor", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087572749", "display_name": "CYTOPLASMIC ACTIVATORS OF HUMAN MUSCLE GENES", "description": null, "funder_award_id": "5r01hd020203-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1986-04-01", "end_date": "1990-03-31", "start_year": 1986, "end_year": 1990, "landing_page_url": "https://reporter.nih.gov/project-details/3318133", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HELEN M", "family_name": "BLAU", "orcid": null, "role_start": null, "affiliation": {"name": "STANFORD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087574129", "display_name": "RETROVIRAL CODED FUNCTIONS", "description": null, "funder_award_id": "5r01ca018282-25", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 399026.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1978-12-01", "end_date": "2002-02-28", "start_year": 1978, "end_year": 2002, "landing_page_url": "https://reporter.nih.gov/project-details/6172189", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MAXINE L", "family_name": "LINIAL", "orcid": null, "role_start": null, "affiliation": {"name": "FRED HUTCHINSON CANCER RESEARCH CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087578911", "display_name": "Complement and Inflammatory Factors in AD Pathogenesis", "description": null, "funder_award_id": "5r01ns035144-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 350839.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1997-02-01", "end_date": "2009-03-30", "start_year": 1997, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7198179", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANDREA JOAN", "family_name": "TENNER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA-IRVINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087579509", "display_name": "ADVANCED MCP UV VISIBLE DETECTOR SYSTEMS", "description": "ADVANCED MCP UV VISIBLE DETECTOR SYSTEMS", "funder_award_id": "NAG59149", "funder": {"id": "https://openalex.org/F4320306101", "display_name": "National Aeronautics and Space Administration", "doi": "10.13039/100000104"}, "amount": 496989.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "RESEARCH GRANTS FOR THE SPACE PROGRAM", "start_date": "2006-05-29", "end_date": "2006-06-10", "start_year": 2006, "end_year": 2006, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_NAG59149_080/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408757976", "display_name": "Toward Gravitational Wave Discovery with Advanced LIGO", "description": "The UWMLSC group will contribute several critical elements to create a low-latency streaming on-line search for transient gravitational waves, such as those produced during the coalescence of binary neutron stars or black holes, the most anticipated gravitational wave signal. Among the data analysis elements we will create are the streaming data calibration system, a low-latency system for determining data quality and glitch vetoing, and on-line searches for signals from inspiralling compact binaries and for generic unmodeled bursts. Such a system to rapidly identify signals will be an essential element of gravitational wave science in the Advanced Detector Era, and will enable multi-messenger astronomy in which observations of several kinds (gravitational waves; electromagnetic waves; high energy particles) are synthesized to obtain a detailed understanding of the sources of the most cataclysmic events in the universe. Gravitational wave astronomy will reveal the inner mechanism of the mysterious gamma ray bursts, will provide a means to measure the population of black holes and determine the channel by which massive black holes are grown, and will probe the fundamental nature of matter above nuclear densities. New ways of measuring cosmological parameters will become available, which will complement existing observations. Gravitational wave observations will also provide sensitive tests of Einstein's General Relativity in ways in which it has not yet been scrutinized. The opening of the gravitational wave window onto the universe can potentially evince exotic objects such as naked singularities, cosmic strings, or unexpected physics. We must be ready to address these scientific challenges as our new astronomical facilities come into operation. To this end, this award will support work that may result in the first gravitational wave discoveries of compact binary coalescence, provide rapid sky localization to facilitate electromagnetic follow-up efforts, yield fast turn-around targeted searches prompted by triggers generated by other observational facilities, obtain the the nuclear equation of state by measuring the tidal interactions of binary neutron stars just prior to their merger, observe black hole formation channels and probe fundamental properties of black holes through their quasi-normal modes of oscillation, scan the sky to find undiscovered rapidly rotating neutron stars and to learn about their properties, test cherished principles of gravitation such as the no-hair and cosmic-censorship conjectures, and seek new exotic and unexpected phenomena.\r\n\r\nOur work supports the creation of critical components of a system that will allow the rapid transmittal of gravitational wave observations to the entire community of astronomers, and facilitates the integration of gravitational wave science into the broader field of astrophysics. The group has a solid track record of educating new researchers; this project will have a broad impact by training a new generation of graduate students, postdoctoral fellows and junior faculty members in gravitational-wave astronomy, as well as conveying the excitement of this budding branch of astronomy to the community through outreach efforts such as the UWM Planetarium.", "funder_award_id": "1307429", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 960000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2013-08-15", "end_date": "2016-07-31", "start_year": 2013, "end_year": 2016, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307429", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Jolien", "family_name": "Creighton", "orcid": null, "role_start": null, "affiliation": {"name": "University of Wisconsin-Milwaukee", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087581186", "display_name": "Smart Renewable Energy Manager for the Industrial Prosumer Market", "description": "The progressive reduction in price of renewable energy and energy storage due to technology innovation and production enhancements is revolutionising the energy sector by turning the traditional centralised power system into a new decentralised one. Commercial and industrial (CI) consumers are increasingly implementing distributed energy resources (DERs) such as solar photovoltaic (PV), local batteries and electric vehicle (EV) charging stations in their facilities to lower their energy cost, increase security of supply and decarbonise the economy.By implementing an increasing number of DERs, CI consumers become prosumers (producers and consumers). Prosumers must manage their own generation, storage and consumption. Therefore, there is an urgent need to develop energy management tools able to cost-effectively integrate and operate generation, storage and loads. Moreover, new opportunities to make profit arise with the implementation of DERs (especially from the potential of the pair distributed generation plus storage) regarding the traditional scheme.SREM is an innovative Smart EMS specifically designed to fill the need to automate the management of loads and the increasing number of DERs in the CI market. Its differentiating and proprietary algorithms aim to achieve the highest financial return (15%-30% energy savings). SREM has been developed by Effinnova Management (Effinnova) a Spanish start-up company that is providing substantial economic savings through energy management services to its industrial and commercial customers and that has noted its customers urgent need to develop new energy management tools to integrate a growing number of DERs in their facilities aiming to reach economic gains, facilitate its operation control and increase the security of supply. The benefits that this technology will bring to the market will make the proposed project profitable with a ROI of 7 over 5 years and a payback period just above 2 years.", "funder_award_id": "809475", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 50000.0, "currency": "EUR", "funding_type": "commercial", "funder_scheme": "H2020 - SME-1", "start_date": "2018-02-01", "end_date": "2018-05-31", "start_year": 2018, "end_year": 2018, "landing_page_url": "https://cordis.europa.eu/project/id/809475", "doi": "10.3030/809475", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "EFFINNOVA MANAGEMENT SL", "country": "ES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087582500", "display_name": "13世紀から16世紀までの中央ユーラシアにおけるテュルク（トルコ）民族の歴史", "description": "Principal Investigator：川口 琢司, Project Period (FY)：1999, Research Category：Grant-in-Aid for Encouragement of Young Scientists (B), Research Field：歴史", "funder_award_id": "11904002", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 210000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (B)", "start_date": "1999-04-01", "end_date": "1999-03-31", "start_year": 1999, "end_year": 1999, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11904002/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087583587", "display_name": "Pre-College Teacher Development in Science", "description": null, "funder_award_id": "8100883", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 26478.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1981-04-06", "end_date": "1982-09-30", "start_year": 1981, "end_year": 1982, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8100883", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Jill", "family_name": "Wright", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087583817", "display_name": "GOALI (Faculty in Industry): Powder Technology", "description": "Prof. D.J. Quesnel will conduct research work in the area of particle technology and prepare a related short course during a sabbatical year visit at the Elmgrove Facility of Kodak Co. Six related research/education areas will be considered at the beginning of the visit, including powder flow, toner dusting, toner transfer, fine toner handling, molecular dynamic study of particle adhesion, and training in powder mechanics. Based on that experience, the P.I. will focus his activities on a major research thrust in the second part of the visit. This is a GOALI Faculty in Industry proposal. It is expected that the visit will foster long term collaboration between the University of Rochester and Kodak Co., with benefits for both research and educational programs on powder technology.", "funder_award_id": "9708606", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 40161.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1997-08-01", "end_date": "1998-07-31", "start_year": 1997, "end_year": 1998, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9708606", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "David", "family_name": "Quesnel", "orcid": null, "role_start": null, "affiliation": {"name": "University of Rochester", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087584059", "display_name": "MATERNAL MORTALITY EFFECTS OF ABORTION LEGALIZATION", "description": null, "funder_award_id": "1r03hd036425-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R03", "start_date": "1998-05-01", "end_date": "1998-07-31", "start_year": 1998, "end_year": 1998, "landing_page_url": "https://reporter.nih.gov/project-details/2600678", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM CLINTON", "family_name": "DOW", "orcid": null, "role_start": null, "affiliation": {"name": "RAND CORPORATION", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087584148", "display_name": "Exploiting Genetic Diversity of Essential Micronutrients in Duckweeds for Human Nutrition", "description": "Duckweeds are fast growing aquatic plants that have excellent nutritional qualities (high protein content, valuable omega-3 fatty acids and essential micro-nutrients), suggesting high potential for human and animal nutrition. Recent research suggest that there is a significant genetic variation for these nutritional qualities in different species and even intraspecific duckweeds. However, the genetic basis of such variation in duckweeds remains unclear. We aim to pinpoint the genetic basis underlying the variation of nutritional qualities in duckweeds towards developing toolkit for selecting suitable duckweed genotypes for future applications in human and animal nutrition. In this DTP studentship, we will primarily focus on the nutritional quality of essential omega-3 fatty acids and amino acids, which are important in a wide variety of physiological processes in human and animal health. Same as originally submitted except we have included Amino acid profiling along with the fatty acids.", "funder_award_id": "2434913", "funder": {"id": "https://openalex.org/F4320334629", "display_name": "Biotechnology and Biological Sciences Research Council", "doi": "10.13039/501100000268"}, "amount": null, "currency": "GBP", "funding_type": "studentship", "funder_scheme": null, "start_date": "2020-09-30", "end_date": "2024-12-30", "start_year": 2020, "end_year": 2024, "landing_page_url": "https://gtr.ukri.org/projects?ref=2434913", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087584598", "display_name": "ICU-ROOM : Intensive Care Unit Rooms, Objectified, Observed and Measured.", "description": "Intensive Care Units (ICU) are the places in hospital where the sickest patients are treated. Complications of treatment in ICU are common. We found one in four patients in Canadian ICUs have a treatment-related complication - an adverse event. Examples include: new infections, medical devices 'falling out' and skin breakdown. Each year tens of millions of dollars are spent to improve patient safety by reducing adverse events. Our recent review suggests that the way ICUs are designed effects how care is provided to patients and contributes to adverse events. Building an ICU costs tens of millions of dollars, and happens every 20-40 years. It seems sensible that ICU design should be focussed on helping ICU professionals provide safe, high-quality care minimizing complications and providing the best possible experience for family members when visiting their loved one. In this project we want to find out HOW ICU design affects patient safety - we will measure adverse events. We will also ask ICU professionals and patient's loved ones about their experiences working in and visiting these 200 bedspaces in ICU's across Canada. Common sense tells us things like how big patient rooms are, how far rooms are apart, how close key equipment is, the quality of amenities for visitors, and how well patients and patient-monitors can be seen from nursing stations are important. Common sense also suggests that ICU professionals are resourceful and adapt to overcome challenges - including those related to ICU design. Knowing what happens in the real-world is important: bedspace types linked to the most adverse events can receive extra attention to reduce risk to patients. Architects can avoid unfavourable features as they design new ICUs. Bedspace types linked to the least adverse events and the most favourable visitor experiences can be built into future renovations and new designs - to improve the outcomes of critically ill patients across Canada and around the world.", "funder_award_id": "183917_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 1392301.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Project Grant", "start_date": "2022-10-01", "end_date": "2026-09-30", "start_year": 2022, "end_year": 2026, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Christopher", "family_name": "Parshuram", "orcid": null, "role_start": "2022-10-01", "affiliation": {"name": "Hospital for Sick Children (Toronto)", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087585164", "display_name": "白血病誘発機構に関する研究", "description": "Principal Investigator：渡辺 漸, Project Period (FY)：1971, Research Category：Grant-in-Aid for Cancer Research", "funder_award_id": "92346", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4200000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Cancer Research", "start_date": "1971-04-01", "end_date": "1971-03-31", "start_year": 1971, "end_year": 1971, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X46021-----92346/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408758572", "display_name": "Post-growth and sustainability: imagining and experimenting with balanced artistic models", "description": "The IMAGINART project proposes to imagine and experiment with balanced artistic theories and practices to respond to the ecological crisis, which is at once environmental, social and mental. To do this, it mobilises two concepts that are able to cross these three ecological registers, (1) the degrowth in resources, thought of as a way to achieve a post-growth society and (2) the sustainability of technologies, i.e. the invention or use of more sustainable technologies. IMAGINART focuses on music / sound arts and digital visual arts, whose creative mediums are highly dependent on technological and energy resources. The project is interdisciplinary, bringing together researchers in the arts and researchers in post-growth. It adopts a methodology that combines fundamental research and research-creation. It is composed of 5 WPs that are interdependent while being dedicated to differentiated tasks: -WP 0 is dedicated to the management and coordination of the project; -WP 1 is designed as the foundation of the project, dedicated to fundamental research (and action research): its mission is to conceptualise and theorise post-growing artistic practices and sustainable artistic technologies, as well as to conduct a field survey to gain an overview of the state of the art, complementing the developments specific to the project; -WPs 2 and 3, dedicated to research-creation, are complementary. WP 2 consists of residencies for guest artists, conceived as places conducive to the emergence of balanced artistic solutions. Based on the ideas that emerge in WP 2, WP 3 focuses on the means of artistic production by developing and experimenting with post-growing and sustainable tools, then considering the artistic performances that will use these tools. These two WPs interact with WP 1 throughout the project; - WP 4 is responsible for the documentation and dissemination of the project. The project is coordinated by Makis Solomos (MUSIDANSE, 50% FTE), honorary member of the IUF, Professor of Musicology at the University of Paris 8, specialist in contemporary music and sound arts, in the music of Xenakis, and in the ecology of sound and music (his book Exploring the Ecologies of Music and Sound was recently published by Routledge). The other scientific responsibles are: Jean-François Jégo (AIAC/INREV, 25% FTE), artist-researcher, Senior Lecturer in the Department of Image Arts & Technologies at the University of Paris 8; João Fernandes (CEAC, 25% FTE), artist-researcher, Senior Lecturer in the Music Department at the University of Lille; Christine Esclapez (PRISM, 25% FTE), Professor of Musicology at AMU; Angelos Varvarousis (ICTA-UAB, 17% FTE), specialist in degrowth, Senior Researcher Fellow at the University of Barcelona. The laboratories involved are: MUSIDANSE (University of Paris 8), specialising in musical or sound creation; the INREV team of the AIAC laboratory (University of Paris 8), which experiments with and theorises research-creations on the relationships between digital visual arts and the performing arts; CEAC (University of Lille), which aims to explore contemporary creative processes and forms; PRISM (AMU), specialising in research-creation and epistemology of arts/sciences interactions; the Institute of Environmental Science and Technology (ICTA-UAB, Spain), which includes world specialists in post-growth. The project has academic, artistic, educational, social and ecosophical (combining the three ecological registers) impacts.", "funder_award_id": "ANR-25-CE54-6646", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 388664.86, "currency": "EUR", "funding_type": "research", "funder_scheme": "AAPG2025", "start_date": "2026-01-01", "end_date": null, "start_year": 2026, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-25-CE54-6646", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Angelos", "family_name": "VARVAROUSIS", "orcid": null, "role_start": null, "affiliation": {"name": "Institute of Environmental Science and Technology (ICTA-UAB)", "country": "France", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087586269", "display_name": "CELLULAR CALCIUM REGULATION IN MYOPATHIC HEARTS IN VITRO", "description": null, "funder_award_id": "5r01hl041883-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1990-01-01", "end_date": "1994-12-31", "start_year": 1990, "end_year": 1994, "landing_page_url": "https://reporter.nih.gov/project-details/3359682", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MEREDITH", "family_name": "BOND", "orcid": null, "role_start": null, "affiliation": {"name": "CLEVELAND CLINIC FOUNDATION", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408759", "display_name": "Metabolic Studies of Low Density Lipoproteins", "description": null, "funder_award_id": "6112563", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1961-01-01", "end_date": "1963-01-01", "start_year": 1961, "end_year": 1963, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=6112563", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087592718", "display_name": "Die Bedeutung der Ross/panafrikanischen Orogenese im Bereich Kirwanveggen/Sverdrupfjella (Neuschwabenland)", "description": "Im Rahmen der südafrikanischen \"Earth Sciences Expedition to western Dronning Maud Land 1997/98\" wurde als Teilprojekt eines der Hauptforschungsziele der Antarktisgeologie \"Supercontinent assembly and dispersal: Antarctica and global geoynamics\" die Bedeutung der Ross-/panafrikanischen Orogenese im Raum Kriwanveggen/Sverdrupfjella (Westneuschwabenland) untersucht. Dies erfolgte in erster Linie mit strukturgeologischen Methoden und durch den naheliegenden Vergleich mit entsprechenden Ergebnissen des Antragstellers in der Shackleton Range. Anhand der im Gelände gewonnenen strukturellen Daten und dem umfangreichen Probenmaterial sollen Alter und Deformationsentwicklung von Überschiebungssystemen in Süd- (Polaris Ridge-Region) und Zentral-Kirwanveggen (Tverregga) sowie der Urfjell-Gruppe geklärt werden. In den entsprechenden Einheiten sollen sowohl ross-orogenetische Einengungsstrukturen als auch Orogene-Kollaps-Indikatoren wie LANFs und Knickbänder analysiert und bewertet werden. Schließlich soll versucht werden, Spuren der Westfortsetzung des Mocambique-Ozeans nachzuweisen, denn in der Shackleton Range konnte dieser Nachweis inzwischen erbracht werden.", "funder_award_id": "5386113", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 439766.6615, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "1997-01-01", "end_date": "2001-12-31", "start_year": 1997, "end_year": 2001, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/5386113", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087595719", "display_name": "ラジアル型超伝導軸受を用いたリニアアクチュエータのファジィ制御", "description": "Principal Investigator：小森 望充, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：電力工学", "funder_award_id": "02750190", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 700000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1990-04-01", "end_date": "1990-03-31", "start_year": 1990, "end_year": 1990, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02750190/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087596122", "display_name": "DEMONSTRATION OF NOVEL TECHNOLOGY TO PROVIDE PHYSIOLOGICAL MONITORING OF PATIENTS WITH TRAUMATIC BRAIN INJURY DURING INTENSIVE OUTPATIENT PROGRAM", "description": "DEMONSTRATION OF NOVEL TECHNOLOGY TO PROVIDE PHYSIOLOGICAL MONITORING OF PATIENTS WITH TRAUMATIC BRAIN INJURY DURING INTENSIVE OUTPATIENT PROGRAM", "funder_award_id": "HU00011720011", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 239854.29, "currency": "USD", "funding_type": "grant", "funder_scheme": "UNIFORMED SERVICES UNIVERSITY MEDICAL RESEARCH PROJECTS", "start_date": "2017-04-01", "end_date": "2019-07-31", "start_year": 2017, "end_year": 2019, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_HU00011720011_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4087599464", "display_name": "カイコの笹繭形質の原因遺伝子の解明とその応用", "description": "「笹繭」は、繭にフラボノイド系の色素を蓄積する形質であり、複雑な遺伝的支配を受ける。私たちの研究室は、すでにGb遺伝子の単離に成功したが、本研究では、別の遺伝子の探索と遺伝分析を進めた。古くから、笹繭形質にはZ染色体に連鎖するGre(緑卵)遺伝子が関与していることが知られているので、この遺伝子のマッピングを進めた。すなわち、o06×(o06×f04)の交雑後代をDNAマーカーで分析したが、原因遺伝子の特定には至らなかった。一方、Gre遺伝子の機能を解明するため、正常卵(+^This grant supports planning and analysis of observations taken by the Nuclear Spectroscopic Telescope ARray (NuSTAR) satellite, a NASA small Explorer space mission whose primary mission is in astrophysics. NuSTAR is the next generation of X-ray observatories to be launch in May 2012 and provides a 200-fold advance in hard X-ray sensitivity over current capabilities that will open up entirely new view of astrophysical objects in X-rays including our Sun. The newly established group in ‘Applied High-Energy Heliophysics’ at University of Applied Sciences Northwestern Switzerland (FHNW) funded by this grant is part of the NuSTAR science team in charge of NuSTAR observations of our Sun. The main goal of this grant is to study why the solar atmosphere at temperatures of several million degrees is that much hotter than the solar surface at 6000 degree. With the extraordinary increase in sensitivity provided by NuSTAR, we will be able to test the so-called ‘nanoflare heating’ theory predicting that many tiny explosions seen in X-rays provide enough energy to keep the solar atmosphere at that extraordinary hot temperature.
", "funder_award_id": "140308", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 436375.0, "currency": "CHF", "funding_type": "research", "funder_scheme": "Project funding", "start_date": "2013-01-01", "end_date": "2016-12-31", "start_year": 2013, "end_year": 2016, "landing_page_url": "https://data.snf.ch/grants/grant/140308", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Krucker,", "family_name": "Samuel", "orcid": null, "role_start": null, "affiliation": {"name": "University of Applied Sciences and Arts Northwestern Switzerland (without UTE) – FHNW", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088288411", "display_name": "HPLC SYSTEM, LC, FPLC SYSTEM, ANOMALOSCOPE, WATSMART", "description": null, "funder_award_id": "1s15hd023558-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "S15", "start_date": "1987-09-01", "end_date": "1988-08-31", "start_year": 1987, "end_year": 1988, "landing_page_url": "https://reporter.nih.gov/project-details/3525017", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARK", "family_name": "DUBIN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO AT BOULDER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088288901", "display_name": "Travel to Attend: Conference on Commutative Algebra and Algebraic Geometry; Oberwolfach, West Germany; May 10-13, 1979", "description": null, "funder_award_id": "7918823", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 893.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1979-05-10", "end_date": "1979-11-30", "start_year": 1979, "end_year": 1979, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7918823", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Joseph", "family_name": "Lipman", "orcid": null, "role_start": null, "affiliation": {"name": "Purdue University", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088289091", "display_name": "Collaborative Research: Lightning and Associated Electrical Activity at Erupting Volcanoes", "description": "Recent studies of Augustine Volcano, funded by other sources, have shown that there are two distinct types of observable electrical activity associated with eruptions. One is a newly discovered continuous radio frequency (RF) radiation at the crater mouth during the main eruption, and the other is large-scale lightning in the volcanic plume several minutes after the main eruption, with characteristics similar to lightning found in thunderstorms. These observations, made using Lightning Mapping Array (LMA) instrumentation developed at the New Mexico Institute of Mining and Technology, were the first detailed, high time resolution observations of such volcanic electrical activity. In this new research program volcano-produced electrical activity will be observed at two permanent sites in Alaska with an array of atmospheric electrical instrumentation including the LMA to make detailed three-dimensional images of the electrical activity; and electric field mills, fast antennas and slow antennas to characterize the polarity of the lightning activity. A low-power version of the LMA sensor will be developed, which will allow for long-term monitoring of volcanic electrical activity in remote locations, and for rapid deployment to sites with no grid power available. The research will involve both scientific studies of volcanic lightning and electrical activity, and continued development and advancement of the instrumentation for making such observations. The intellectual merit of the proposed research will derive from the scientific investigations. One major scientific goal is to use lightning mapping observations to ascertain the electrical structure of volcanic plume clouds. This will help lead to a better understanding of the charging mechanism in the plume. A second major goal is to better characterize the continuous RF activity during the explosive phase. A third major goal is to ascertain the usefulness of monitoring of electrical activity as an additional tool for the determination of the status of active volcanoes.\r\n\r\nBroader impacts of the proposed activity will include further development of the lightning mapping technique as a useful technology to study and monitor volcanic eruptions. The system that will be developed could evolve into one that could be used to monitor a volcano and confirm eruptions, even when weather conditions preclude visual observations. It could be used as an additional tool to help volcanologists in their decision-making process for generating warnings to nearby populations, and to aircraft. Tracking of the in-plume lightning can give the direction that the ash cloud is moving. The system will give the volcanologists another tool to study the eruptions with high time resolution. The understanding of charging in the volcanic plume could lead to a better understanding of the charging in thunderstorms. A final aspect of the proposed research will be the development of a set of lightweight, solar-powered, battery-operated mapping stations that can be readily deployed for a variety of experiments and studies that are as yet not easily conducted. The involvement of graduate and undergraduate students both in the scientific and applied aspects of the research has broad implications for their education that can only come from working on real problems. This research will involve a collaboration between atmospheric and earth scientists in a cross-disciplinary environment. Inter-agency and international collaborations will be established as needed to work with groups in areas where it looks reasonable to deploy our instrumentation to study active volcanoes. This interdisciplinary activity has already introduced new techniques that will be used for monitoring active volcanoes in Alaska. The collaborations will become broader as interactions develop with volcanologists and disaster planners in communities near volcanoes around the world.", "funder_award_id": "0739114", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 104243.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2008-02-15", "end_date": "2012-01-31", "start_year": 2008, "end_year": 2012, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0739114", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Stephen", "family_name": "McNutt", "orcid": null, "role_start": null, "affiliation": {"name": "University of Alaska Fairbanks Campus", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088290250", "display_name": "Development of a new method for structural modeling of protein-membrane complexes", "description": "We developed three new methods for reliable structural modeling of protein-membrane complexes: Voronoi tessellation Monte Carlo integration method, Surface-tension replica-exchange molecular dynamics method, and Method to predict the optimal orientation of membrane proteins with Generalized Born implicit membrane model. These methods are useful to perform reliable molecular dynamics simulations of membrane proteins and mixed lipid bilayer systems like lipid rafts.", "funder_award_id": "23770192", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3640000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23770192/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Takaharu", "family_name": "MORI", "orcid": null, "role_start": null, "affiliation": {"name": "The Institute of Physical and Chemical Research", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000090402445", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088296617", "display_name": "Intensive Palliative Care: Improving the Process of Palliative Ventilator Withdrawal Among Critically Ill Older Adults", "description": "This research is relevant to public health as more than 1 in 5 Americans die in intensive care units (ICUs), and the majority of patients are older adults with advanced illness. This proposal will generate information to reduce distress among older ICU patients on mechanical ventilation who are transitioning to comfort focused care, and an intervention with the ICU team of nurses, doctors and therapists to improve symptom control. First, to better understand the patient experience and providers’ perspectives, ICU patients over 60 years old will be followed prospectively during the process of removing ventilator support; Second, a checklist intervention for the ICU team will be developed to improve the process of removing ventilator support; Finally, a pilot study will determine if the intervention is feasible to conduct and provide information for future studies to gauge efficacy in reducing episodes of distress.", "funder_award_id": "5k23ag066929-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 194400.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2020-04-15", "end_date": "2025-03-31", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10143172", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "COREY R", "family_name": "FEHNEL", "orcid": null, "role_start": null, "affiliation": {"name": "HEBREW REHABILITATION CENTER FOR AGED", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088296735", "display_name": "Molecular studies of VZV infection, latency and reactivation in human neurons in-vitro", "description": "PUBLIC HEALTH RELEVANCE: Most people worldwide are infected by varicella zoster virus (VZV) when they have chickenpox. Virus then remains in their nerves for life: in about a third of people, it reemerges late in life to cause \"shingles\", a painful and debilitating disease that can have major life-changing long-term consequences, including loss of vision. The state of the virus in neurons and what leads to reawakening have been extraordinarily difficult to study. We now have a cultured human neuron system that recapitulates latency and reactivation, and the work proposed will use it to study VZV latency reemergence and the means to prevent them. ", "funder_award_id": "1r01ai122640-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 470273.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2015-11-12", "end_date": "2020-10-31", "start_year": 2015, "end_year": 2020, "landing_page_url": "https://reporter.nih.gov/project-details/9052861", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PAUL R.", "family_name": "KINCHINGTON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088297326", "display_name": "A new model of heterogeneity in schizophrenia based on severity of illness and familial characteristics", "description": null, "funder_award_id": "67088_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 257095.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Operating Grant", "start_date": "2004-04-01", "end_date": "2007-03-31", "start_year": 2004, "end_year": 2007, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Marc-Andre", "family_name": "Roy", "orcid": null, "role_start": "2004-04-01", "affiliation": {"name": null, "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088298348", "display_name": "Plasticity and Energy Adaptations in Cancer Cell Migration", "description": null, "funder_award_id": "PAT4730323", "funder": {"id": "https://openalex.org/F4320321181", "display_name": "Austrian Science Fund", "doi": "10.13039/501100002428"}, "amount": 478720.84, "currency": "EUR", "funding_type": "grant", "funder_scheme": null, "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://www.fwf.ac.at/en/research-radar/10.55776/PAT4730323", "doi": "http://dx.doi.org/10.55776/pat4730323", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088298822", "display_name": "Evolution of Sex-determining Mechanisms", "description": null, "funder_award_id": "6320682", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1963-01-01", "end_date": "1965-01-01", "start_year": 1963, "end_year": 1965, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=6320682", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088302267", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "234270-2000", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Industrial Undergraduate Student Research Awards", "start_date": "2000-04-01", "end_date": "2001-03-31", "start_year": 2000, "end_year": 2000, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=234270-2000", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Annette", "family_name": "Badry", "orcid": null, "role_start": null, "affiliation": {"name": "Novartis Crop Protection Canada Inc.", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088307262", "display_name": "Mechanism of Action of Retinoic Acid Using CD38", "description": "PUBLIC HEALTH RELEVANCE: This is a multi investigator proposal to study the mechanism of action by which retinoic acid (a form of vitamin A) reverses a neoplastic phenotype. Retinoic acid (RA) is a well known cancer chemopreventive agent also used in differentiation induction cancer chemotherapy, which exploits its ability to reverse a proliferatively active, differentiatively immature neoplastic phenotype to a proliferatively quiescent, differentiatively mature phenotype. The proposed studies investigate how the CD38 receptor contributes propulsion to RA-induced differentiation/arrest. In summary the studies will show how different CD38 activities contribute propulsion to the RA-induced phenotypic conversion and growth arrest of differentiation.", "funder_award_id": "5r01ca152870-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 325385.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2011-07-01", "end_date": "2016-06-30", "start_year": 2011, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8280329", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "QUAN", "family_name": "HAO", "orcid": null, "role_start": null, "affiliation": {"name": "CORNELL UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088308628", "display_name": "Immunochemotherapy in Visceral Leishmaniasis", "description": " Project Narrative: Relevance of This Research Improving treatment in patients with visceral leishmaniasis (kala-azar) is relevant to NIH's health mission for three reasons: (a) this infection is a most neglected parasitic disease with recognized significance in endemic regions, (b) without vaccine to prevent infection, the only practical avenue to advancing its clinical manage- ment is new treatment approaches, and (c) this experimental research in animals will show how to best har- ness host immune mechanisms to meaningfully enhance effectiveness of antileishmanial drug therapy. To develop and apply combination immunochemotherapy, our research objectives are to amplify and accelerate initial drug-induced parasite killing and strengthen long-lasting effects to prevent posttreatment relapse of residual visceral infection. This project's objectives and experimental strategies also hold the promise of improving treatment in other similar infections in which host defense depends on optimally activating T cell- dependent immune mechanisms.", "funder_award_id": "1r01ai083219-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 487832.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2010-02-05", "end_date": "2015-01-31", "start_year": 2010, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/7883961", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HENRY W.", "family_name": "MURRAY", "orcid": null, "role_start": null, "affiliation": {"name": "WEILL MEDICAL COLL OF CORNELL UNIV", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088308761", "display_name": "37th International Congress on Limnology", "description": null, "funder_award_id": "24/00193-8", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Brasil", "start_date": "2024-05-05", "end_date": "2024-05-09", "start_year": 2024, "end_year": 2024, "landing_page_url": "https://bv.fapesp.br/en/auxilios/24-00193-8/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Ricardo", "family_name": "Hideo Taniwaki", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade Federal do ABC (UFABC). Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40883112", "display_name": "Collaborative Proposal: Students' Attempts at Understanding the Unobservable: A Multi-Method Approach to Visualization Analysis and Design (Empirical Contextual Research Strand)", "description": "Student comprehension of scientific concepts and principles presents a particular challenge when the phenomena are not directly observable. This issue has emerged as core to effective teaching and successful student learning in chemistry. The goal is to identify whether students' individual differences influence the effectiveness of visualizations for learning scientific concepts as measured with process and product-based metrics of evaluation. The investigators will also develop design principles for the use of visualizations as instructional tools in chemistry and STEM fields more broadly.\r\n\r\nThe central issues are: When and how students rely on visualizations while trying to comprehend unobservable chemistry content; whether reliance on visualizations varies as a function of student characteristics; and whether usage patterns inform instructional interventions. In a series of randomized, controlled experiments involving undergraduates at four institutions, investigators will: (a) determine baseline chemical knowledge, spatial ability, reasoning ability, and interest in learning; (b) use eye tracking to characterize the moment-by-moment scan and fixation processes that students rely on while viewing visualizations; (c) utilize concurrent interview protocols to assess learning strategies and knowledge acquisition; and (d) implement post-visualization tests to examine student memory for the visualization content and application of knowledge.", "funder_award_id": "0907780", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 277363.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2009-09-01", "end_date": "2013-08-31", "start_year": 2009, "end_year": 2013, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907780", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Mary Jane", "family_name": "Shultz", "orcid": null, "role_start": null, "affiliation": {"name": "Tufts University", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088313107", "display_name": "The Ontology and Culture of Queer+ Classical Performance, Urban Geographies, and Community Engaged Art", "description": null, "funder_award_id": "20998938", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 10000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "SSHRC Doctoral Awards", "start_date": "2022-04-01", "end_date": null, "start_year": 2022, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Caines, Jacob Edward", "orcid": null, "role_start": null, "affiliation": {"name": "Concordia University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088313802", "display_name": "胎仔環境下におけるケロイド組織の変化および同組織中のTGF-βのmRNAの発現", "description": "本研究は妊娠ヌードマウス(nu/nu)を用い、母親および胎仔の皮下にヒトケロイド組織を移植し、これによりケロイド組織が胎仔環境下で変化を受けるか否かを、見ることを目的として始まった。われわれは予備実験として、まず胎児環境を調べるため、マウス胎児における線維芽細胞のTGF-beta 1作用によるコラーゲン産成能の変化、組織学的に胎児期の創傷治癒がハンコンなく治癒する時期から、ハンコンが出現する時期へ変化する時点を明らかにすることとした。妊娠13日から18日のマウス計、30匹に胎児手術を施し、創を作製した後3日、5日目に採取し、ホルマリン固定後、H-E染色によりこの時期を確認した。その結果、マウスにおいては妊娠15日目と16日目の間にこの変化が起こることが示された。次に胎生13日から18日の各胎児から線維芽細胞を初代培養し、その後継代培養し各時期からの線維芽球細胞からmRNAを抽出し、TGF-beta 1に対するcDNAによりnothern hybridizationを行い、各時期のTGF-beta 1 mRNAの発現を観察した。その結果、培養線維芽球細胞においては胎生13日から16日でTGF-beta 1 mRNAの発現が強く、以後漸減し、成獣マウス線維芽細胞において再び発現が強くなることが示された。今回の研究はここで科研費が終了し、残念ながらここまでの研究となった。しかし胎児の創傷治癒において、ハンコンがない時期からハンコンが残る時期への転換点を明らかにした報告はなく、本研究の意義は大きかったと思われる。", "funder_award_id": "07857078", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1995-04-01", "end_date": "1995-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07857078/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "和生", "family_name": "貴志", "orcid": null, "role_start": null, "affiliation": {"name": "Keio University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000040224919", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088314152", "display_name": "Auditory Perception of Drug Names: Neighborhood Effects", "description": null, "funder_award_id": "1r01hs011609-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-06-01", "end_date": "2007-05-31", "start_year": 2003, "end_year": 2007, "landing_page_url": "https://reporter.nih.gov/project-details/6617155", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BRUCE L.", "family_name": "LAMBERT", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ILLINOIS AT CHICAGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088314246", "display_name": "Demos: A Network for Ideas & Action - to conduct national research and outreach to educate key stakeholders about the financial barriers confronting community college students and to in...", "description": "to conduct national research and outreach to educate key stakeholders about the financial barriers confronting community college students and to investigate and publicize the potential of specific policy solutions to increase completion rates among community college students", "funder_award_id": "OPP1028343", "funder": {"id": "https://openalex.org/F4320306137", "display_name": "Bill and Melinda Gates Foundation", "doi": "10.13039/100000865"}, "amount": 250000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "U.S. Program", "start_date": "2011-06-01", "end_date": "2012-12-30", "start_year": 2011, "end_year": 2012, "landing_page_url": "https://www.gatesfoundation.org/about/committed-grants?q=OPP1028343", "doi": null, "provenance": "gates_foundation", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "Demos: A Network for Ideas & Action", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088314977", "display_name": "MYOCARDIAL ISCHEMIA AND CARDIAC LYMPH: AN INTERACTION", "description": null, "funder_award_id": "5r01hl032619-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1984-01-01", "end_date": "1985-12-31", "start_year": 1984, "end_year": 1985, "landing_page_url": "https://reporter.nih.gov/project-details/3344010", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CAROL A", "family_name": "GERVIN", "orcid": null, "role_start": null, "affiliation": {"name": "VIRGINIA COMMONWEALTH UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088315369", "display_name": "Assessing intraspecific variation in frost tolerance of northern tree species: implications for assisted migration and climate change", "description": "Ironically, assessing whether trees are frost tolerant is critical for helping managed forests adapt to global warming, because one of the most promising adaptation strategies, within-range assisted migration, relies on planting native species using seeds or seedlings that have been imported from warmer climates. This strategy not only assumes that southern transplants will be better adapted to rising temperatures than local trees, but also that they are tolerant of current conditions, particularly growing-season frost. While transplant experiments show that this is true of some species, it is not true of all the species that have been studied, and too few species have been studied to fully assess both the promise and risks of within-range assisted migration. Assessing the frost tolerance of naturally established trees is also critical because global warming will advance the onset of spring growth while also amplifying temperature swings, making trees more vulnerable to frost damage, regardless of whether they are transplants or not. Trees may be particularly vulnerable if they initiate growth at the very beginning of the growing season, as a necessary, but risky adaptation to short growing seasons near the northern limit of a species' range. However, it remains uncertain whether peripheral northern populations are generally more vulnerable to frost than lower-latitude populations, highlighting the need to study naturally established trees as well as transplants. Clearly, predicting and mitigating the impact of climate change requires a better understanding of how frost influences the growth and survival of trees. Toward this end, the proposed research will assess the frost tolerance of transplants and naturally established trees. The three main objectives of the research are: 1) to assess the survival, growth and frost tolerance of transplanted hardwoods, using new transplant experiments; 2) to assess the impact of frost on the long-term growth of a transplanted conifer, using an existing transplant experiment; 3) to assess the impact of frost on naturally established trees, using a national tree-ring database. The proposed research will be of broad interest to scientists studying climate change adaptation because it will test fundamental assumptions about assisted migration. The results will also be valuable to society at large, including natural resource managers and policy makers who need to know how climate change and assisted migration will impact forests. Finally, the results of the new transplant experiments will be of economic interest to the forest sector, whose silvicultural strategies must adjust to the impacts of global warming.", "funder_award_id": "rgpin-2022-04093", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 33000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Discovery Grants Program - Individual", "start_date": "2023-04-01", "end_date": "2024-03-31", "start_year": 2023, "end_year": 2023, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=RGPIN-2022-04093", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "John", "family_name": "Caspersen", "orcid": null, "role_start": null, "affiliation": {"name": "University of Toronto", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088315388", "display_name": "BREAST CALCIFICATION DETECTION BY ACOUSTIC RESONANCE", "description": null, "funder_award_id": "5r01ca071953-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1996-09-01", "end_date": "2000-08-31", "start_year": 1996, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2769885", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHANDRA M", "family_name": "SEHGAL", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088319182", "display_name": "UTMB's Summer Research Program for High School Students", "description": "The University of Texas Medical Branch at Galveston (UTMB) sponsors over six hundred research projects per year. For the past seven years, the Summer Research Program (SRP) for High School Students has filled 107 positions in these projects with 91 students mainly from GalvestonCounty and adjacent Harris County. The SRP will provide sixteen participants a \"hands on\" experience in one research project and an overview of at least 25 other projects. Participants: (1) are hired as laboratory Technical Assistants 40 hour per week for 8 weeks; (2) do projects under the supervision of scientist preceptors; (3) report on their projects either by doing a slide-talk or a poster exhibit; (4) participate in a special research seminar conducted for them by faculty who are not preceptors; (5) discuss possible job choices; (6) participate in various orientation and social activities with peers, preceptors and staff.", "funder_award_id": "8855187", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 67650.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1989-02-15", "end_date": "1991-06-30", "start_year": 1989, "end_year": 1991, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8855187", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "David", "family_name": "McAdoo", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088320030", "display_name": "Mechanism for virus persistence after acute infections", "description": "The persistence of viral genomes after acute viral infections can lead to the development of chronic diseases, including post-viral asthma, encephalitis, and cardiac disease. Our studies indicate that defective viral genomes created during viral replication promote the generation of long-term viral reservoirs by promoting the survival of a subpopulation of infected cells. Our proposed studies will investigate the mechanisms mediating this process and highlight new opportunities for therapeutic interventions to eliminate persistent viruses.", "funder_award_id": "5r21ai127832-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 201250.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2016-12-15", "end_date": "2019-11-30", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/9402051", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CAROLINA B.", "family_name": "LOPEZ", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408832389", "display_name": "STUDIES OF DNA DAMAGE CHECKPOINTS", "description": null, "funder_award_id": "5r01ca077325-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 326634.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-04-20", "end_date": "2003-01-31", "start_year": 1998, "end_year": 2003, "landing_page_url": "https://reporter.nih.gov/project-details/6150281", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PAUL R", "family_name": "RUSSELL", "orcid": null, "role_start": null, "affiliation": {"name": "SCRIPPS RESEARCH INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088327570", "display_name": "Mitochondrial Protein Acetylation and Energy Metabolism in Muscle", "description": "PUBLIC HEALTH RELEVANCE: Obesity and diabetes are associated with decreased skeletal muscle activity of carnitine acetyltransferase (CrAT), an enzyme that regulates energy metabolism. CrAT insufficiency in the skeletal muscle contributes to metabolic dysfunction and compromises exercise tolerance. The proposed research seeks to understand how CrAT enhances muscle metabolism, and to identify potential therapeutic strategies for restoring CrAT function in the context of aging and disease. ", "funder_award_id": "1f32dk105922-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 50690.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2015-04-29", "end_date": "2018-04-28", "start_year": 2015, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/8907479", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ASHLEY SILBERMAN", "family_name": "WILLIAMS", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088328261", "display_name": "Research for the biomarker of invasionand metastasis of oral cancer with partial EMT", "description": "口腔がんには他のがんと同様に転移を起こしやすいものと起こしにくいものがある。これらは手術の後の病理検査では明らかになる事が多いが、手術の前からあらかじめ「転移しやすいがん」がわかっておれば、患者個人に合わせたカスタムメイド治療を組み立てやすくなる。我々は癌細胞が持つ、いろいろな刺激に対して「可塑性」を持つ細胞の性質を解析して、口腔がんのカスタムメイド治療を組み立てる一助とする。", "funder_award_id": "22K10161", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4030000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2022-04-01", "end_date": "2025-03-31", "start_year": 2022, "end_year": 2025, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K10161/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "一馬", "family_name": "野口", "orcid": null, "role_start": null, "affiliation": {"name": "Hyogo Medical University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050309473", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088330477", "display_name": "Designing Spaces of Indigenous Expression and Reconciliation", "description": null, "funder_award_id": "97572", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 17500.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Joseph-Armand Bombardier Canada Graduate Scholarships - Master's", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Nelson, Elizabeth E.", "orcid": null, "role_start": null, "affiliation": {"name": "Queen's University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088331307", "display_name": "ENVIRONMENTAL AND HORMONAL FACTORS IN HIBERNATION", "description": null, "funder_award_id": "5r01hd015912-06", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1981-01-01", "end_date": "1987-12-31", "start_year": 1981, "end_year": 1987, "landing_page_url": "https://reporter.nih.gov/project-details/3313316", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BRUCE D", "family_name": "GOLDMAN", "orcid": null, "role_start": null, "affiliation": {"name": "WORCESTER FOUNDATION FOR BIOMEDICAL RES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088333410", "display_name": "Electrophilic boronate activation: New concepts towards a green and practical catalytic enantioselective carbonyl allylation to access useful pharmaceutical intermediates", "description": "No summary - Aucun sommaire", "funder_award_id": "327800-2005", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 30000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Collaborative Research and Development Grants", "start_date": "2006-04-01", "end_date": "2007-03-31", "start_year": 2006, "end_year": 2006, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=327800-2005", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Dennis", "family_name": "Hall", "orcid": null, "role_start": null, "affiliation": {"name": "University of Alberta", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088334253", "display_name": "Symposium: Tapping the Power of Crustacean Transcriptomes to Address Grand Challenges in Comparative Biology, Portland, Oregon, January 3-7, 2016", "description": "Transcriptomic research approaches allow investigators to comprehensively analyze the profile of messenger RNA used to produce protein in cells or tissue samples. The most popular such approach, called \"RNA-seq\" (for RNA-sequencing) is finding its way into all areas of comparative and integrative biology, yielding insights that are difficult or impossible to attain with the traditional protein-by-protein or gene-by-gene approach. But, there are impediments to using the technology, especially for novel or so-called \"non-model\" organisms. This award will support a symposium, \"Tapping the Power of Crustacean Transcriptomes to Address Grand Challenges in Comparative Biology,\" and associated activities that will be held at the Society for Comparative & Integrative Biology (SICB) meeting in Portland, Oregon Jan. 3-7, 2016. The symposium will help researchers both identify, and move past such impediments. The symposium is co-sponsored by The Crustacean Society and five SICB Divisions. In addition, the PI and symposium organizers are Executive Committee members of the Animal Genome to Phenome Research Coordination Network (AG2P RCN). The program consists of 11 presentations representing six research areas using transcriptomics to a variety of research questions in crustacean biology. There will be a complementary session with speakers selected from submitted abstracts. The accompanying luncheon, feedback booth, Twitter feed, and workshop will further broaden participation across disciplines, gender, ethnicity, and professional rank. \r\n\r\nThe activities supported by this award will include: (1) a lunch scheduled early in the meeting to introduce the AG2P RCN; (2) an RNA-seq feedback booth in the exhibition hall and Twitter feed to gather comments and identify needs from SICB members; and (3) a transcriptomics workshop to review pipelines and best practices that include responses from the feedback booth. Expected outcomes of the workshop include a policy paper on creating an interface and pipeline for the analysis of RNA-seq data, and recruitment of participants in the AG2P RCN. Conference papers planned for publication in the SICB journal, Integrative and Comparative Biology (ICB) will serve as a valuable resource for future researchers.", "funder_award_id": "1551003", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 10600.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2015-12-01", "end_date": "2016-11-30", "start_year": 2015, "end_year": 2016, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1551003", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Donald", "family_name": "Mykles", "orcid": null, "role_start": null, "affiliation": {"name": "Society for Integrative and Comparative Biology", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088336444", "display_name": "PPHF-13-NATIONAL ENVIRONMENT PUBLIC HEALTH TRACKING SYSTEM", "description": null, "funder_award_id": "5u38eh000613-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 426921.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U38", "start_date": "2009-08-01", "end_date": "2014-07-31", "start_year": 2009, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8519995", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MIKE", "family_name": "VAN DYKE", "orcid": null, "role_start": null, "affiliation": {"name": "COLORADO STATE DEPT/PUB HLTH & ENVIRONMT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088337124", "display_name": "Chromatography refrigerator and freezers for plant molecular biology", "description": "A modern molecular biology and biochemistry laboratory requires specialized refrigeration and freezer capacity in order to operate safely and effectively. Of particular importance is long-term storage of research material, often the result of years of work and usually irreplaceable. In addition, many experiments need to be carried out with specialized equipment cooled below room temperature in order to generate accurate, reproducible research results. The current application is to equip the lab of Dr. Christopher Todd, a new faculty member at the University of Saskatchewan, with a chromatography refrigerator, low temperature and ultra-low temperature freezers for use in his NSERC sponsored research program. Dr. Todd's research program examines the regulation of nitrogen metabolism and nitrogen fixation in legume species at the molecular and biochemical levels. Nitrogen fixation in legumes is an extremely important natural mechanism in the global nitrogen cycle since it converts nitrogen, a fundamental component of protein and other biomolecules, to a form usable by the plants. In turn, in agricultural legumes, this provides an important way to provide nitrogen to the diets of both humans and livestock. The current application is to support Dr. Todd's research into understanding how these processes are regulated in plants and how abiotic stresses, such as water limitation, might affect this regulation.", "funder_award_id": "345606-2007", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 18490.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Research Tools and Instruments - Category 1 (<$150,000)", "start_date": "2006-04-01", "end_date": "2007-03-31", "start_year": 2006, "end_year": 2006, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=345606-2007", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Christopher", "family_name": "Todd", "orcid": null, "role_start": null, "affiliation": {"name": "University of Saskatchewan", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088337275", "display_name": "An Open Resource for Autism iPSCs and Their Derivatives", "description": "NARRATIVE The overall purpose of this project is to overcome a critical barrier in the field of autism research; namely, accessibility to statistically relevant numbers of patient-derived neural tissues. Our novel strategy, which is based on our considerable human neural stem cell (NSC), human embryonic stem cell (ESC), and biorepository experience, is to obtain fibroblasts from specific autism and control patients, derive induced pluripotent stem cells (iPSCs) from the fibroblasts, differentiate NSCs from the iPSCs, characterize and contrast and compare these cells using gene microarray and bioinformatics techniques, and provide the cells to specific autism researchers. Dr. James Thomson of the University of Wisconsin will act as consultant for the iPSC portion of this effort. Dr. Jeanne Loring of The Scripps Research Institute will act as consultant for the bioinformatics portion of this effort. This strategy will put the maximum number of patient-derived neural tissues (i.e. neural cell lines) in the maximum number of researchers' hands. Specific Aim #1: Generation and Characterization of Autism and Control iPSC Lines Patient recruitment: Expertise and infrastructure for patient recruitment and consent already exists with the National Human Neural Stem Cell Resource (NHNSCR), which the PI founded and directs. Using the expertise of an existing autism clinical team, specific autism and control patients will be identified and recruited to give consent for donation of either existing fibroblasts or of a piece of biopsy skin from which fibroblasts may be derived. The consortium PI, Dr. Randi Hagerman, of the UCDavis MIND Institute will work with the PI on this goal. In addition, Dr. Jane Pickett of the Autism Tissue Program (ATP) of Autism Speaks, and Dr. Clara Lajonchere of the Autism Genetic Resource Exchange (AGRE) of Autism Speaks will act as consultants. iPSC derivation: iPSCs will be derived from the fibroblasts, using existing methodologies, by transducing them with lentiviral vectors encoding for the transcription factor genes OCT4, NANOG, LIN28, and SOX2. This work will be done in collaboration with Dr. James Thomson of the University of Wisconsin. Considerable expertise for PSC culture and characterization already exists in the PI's lab. In addition, the PI has recently received a supplement from the NIH to add iPSC derivation to his human ESC training course. iPSC characterization: All iPSCs will be characterized using immunocytochemistry and gene microarray (Dr. Jeanne Loring, collaborator) and will be karyotyped and analyzed for identity and stability by SNP genotyping. CNV analysis will also be done (Dr. Heather Mefford, collaborator) iPSCs will be expanded and banked at early and later passages. Specific Aim #2: NSC Differentiation and Characterization Neural Differentiation: iPSCs, after they have been sufficiently expanded, characterized, and banked, will be induced to differentiate down the neural lineage into neural stem cells using established procedures. Considerable expertise for human NSC culture and characterization already exists in the PI's lab. NSC Characterization: NSCs will be characterized using immunocytochemistry and gene microarray and will be karyotyped and analyzed for identity and stability by SNP genotyping. NSCs will be expanded and banked at early and later passages. Specific Aim #3: Cell Distribution Researcher recruitment: Researchers likely to make use of the iPSC/NSCs will be found using the NIH's Crisp database and the researchers database of the Autism Tissue Program and AGRE of Autism Speaks. California researchers meeting these criteria have already been identified and will be the first to benefit from this autism iPSC/NSC repository. Considerable expertise for stem cell distribution already exists in the PI's lab. Training: Researchers wishing to use the iPSCs or the NSCs, but lacking sufficient expertise, will be brought to our laboratories and either thoroughly trained or be allowed to carry out their preliminary studies. Considerable expertise for stem cell training already exists in our laboratory.", "funder_award_id": "1r01hd059967-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 617911.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-08-01", "end_date": "2014-05-31", "start_year": 2009, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/7741492", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PHILIP HITCHINS", "family_name": "SCHWARTZ", "orcid": null, "role_start": null, "affiliation": {"name": "CHILDREN'S HOSPITAL OF ORANGE COUNTY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088337751", "display_name": "Improved analysis of experiments and observational studies in HIV", "description": "NARRATIVE More robust and accurate health knowledge is a cornerstone of better health policy and action. Results from experimental and observational HIV studies can be made better and more policy-relevant through development and use of new methods at the interface of statistics, epidemiology, causal inference, and artificial intelligence. In this work, we propose new and improved estimators of the risk (or survival) function.", "funder_award_id": "5r01ai157758-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 721030.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2020-09-22", "end_date": "2025-08-31", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10460562", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEPHEN R", "family_name": "COLE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408834071", "display_name": "PARENT DEMOGRAPHIC BEHAVIOR--CHILD HEALTH &DEVELOPMENT", "description": null, "funder_award_id": "1r01hd023343-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1987-09-01", "end_date": "1992-08-31", "start_year": 1987, "end_year": 1992, "landing_page_url": "https://reporter.nih.gov/project-details/3323480", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARK R", "family_name": "ROSENZWEIG", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MINNESOTA TWIN CITIES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088341712", "display_name": "W/CuGradientenstrukturen für Komponenten mit unmittelbarem Plasmakontakt in Fusionsreaktoren", "description": "Die Grundlagenuntersuchungen in diesem Vorhaben dienen der Entwicklung von Werkstoffkonzepten für die stationäre Abfuhr von sehr hohen Wärmeflüssen. Solche Belastungsbedingungen treten z.B. an plasmanahen Komponenten von zukünftigen Fusionsreaktoren auf. Das Ziel ist die Klärung des Einflusses eines Gradientenübergangs zwischen plasmaseitigem Wolfram und der Wärmesenke aus einer CuCrZr-Legierung auf die Verringerung thermisch bedingter Spannungen in den durch den Wärmefluss und Temperaturwechsel höchstbelasteten Bauteilen. Im Rahmen des Projektes sollen die Herstellungswege der Gradientenbauteile erforscht, der Belastungsfall analysiert und die auf der Basis lokaler Werkstoffkennwerte ausgelegten Modellkomponenten anwendungsrelevanten Tests unterzogen werden. Dazu wurde im ersten Projektzeitraum eine Vielzahl von geeigneten Modell-Proben mit unterschiedlichem W/CuCrZr-Konzentrationsverhältnis hergestellt und daran die zur Verifizierung der FEM-Modellierung notwendigen ortsabhängigen Werkstoffkennwerte bestimmt. Diese zeigen vor allem anhand der erhöhten mechanischen Eigenschaften den positiven Einfluss der CuCrZr-Legierung im Vergleich zu reinem Kupfer. Die Ergebnisse der FEM-Simulationen sind äußerst vielversprechend, da sie in weiten Teilen sehr gut mit den experimentell bestimmten Kennwerten übereinstimmen. Basierend auf diesen Ergebnissen und der noch zu entwickelnden Technologie zur W/CuCrZr-Gradienten-Modellbauteilherstellung werden im zweiten Teil des Projektes mit Hilfe von FEM-Modellierungen zur Geometrie und Zusammensetzung des gradierten Überganges anwendungsoptimierte W/CuCrZr-Gradientenwerkstoffe hergestellt und diese im Bezug auf die Gefügecharakteristika, das Gradientenprofil bzw. die thermischen Eigenschaften umfassend charakterisiert. Die optimierten Gradientenwerkstoffe werden in geeignete Modellbauteile integriert und in anwendungsnahen Versuchen getestet. Aus den so ermittelten Eigenschaftsprofilen werden in Kombination mit den Ergebnissen der FEMModellierungen in iterativen Schritten Rückschlüsse auf eine weitere Verfahrens- und Werkstoffoptimierung gezogen.", "funder_award_id": "36207724", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 1649124.9806000001, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "2007-01-01", "end_date": "2012-12-31", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/36207724", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088341938", "display_name": "PHASE II STUDY TO COMPARE CDB-2914 AND LEVONORGESTREL", "description": null, "funder_award_id": "n01hd093297-001", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "1999-06-15", "end_date": "2001-09-14", "start_year": 1999, "end_year": 2001, "landing_page_url": "https://reporter.nih.gov/project-details/6140131", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERT WILLIAM", "family_name": "REBAR", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CINCINNATI", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088342423", "display_name": "PARTNERS IN HEALTH-TEACHERS, STUDENTS, PUBLIC - PHASE 2", "description": null, "funder_award_id": "2r25rr012346-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 246497.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R25", "start_date": "1997-09-01", "end_date": "2003-08-31", "start_year": 1997, "end_year": 2003, "landing_page_url": "https://reporter.nih.gov/project-details/6159468", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "E ROBERT", "family_name": "BURNS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088344129", "display_name": "研削加工の適応制御化に関する基礎的研究", "description": "Principal Investigator：安井 平司, Project Period (FY)：1975, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：機械工作", "funder_award_id": "075389", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 330000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1975-04-01", "end_date": "1975-03-31", "start_year": 1975, "end_year": 1975, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X00210----075389/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408834686", "display_name": "Derivation and dopaminergic differentiation of human drug addict-specific iPS cel", "description": " Addiction can be defined as a loss of control of substance use despite adverse consequences. The World Health Organization estimates that there are 2 billion alcohol users, 1.3 billion tobacco users and 185 million illicit drug users worldwide. People who are addicted cannot control their need for the substance of abuse, even in the face of negative health, social or legal consequences. As a result, addiction to legal and illegal substances destroys the lives of both patients and their families, exerting tremendous cost and burden on the society. Unfortunately, the cause of addiction is currently unknown. The molecular- and cellular-based mechanisms that contribute to the initiation and development of addition remain to be elucidated. Results of our studies will provide a detailed characterization of brain cell function in patients afflicted with addiction and will offer insight into the mechanisms that contribute to this complex, devastating disease.", "funder_award_id": "5r21da032962-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 235500.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2011-09-01", "end_date": "2014-08-31", "start_year": 2011, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8324558", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "YU", "family_name": "LUO", "orcid": null, "role_start": null, "affiliation": {"name": "CASE WESTERN RESERVE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088348058", "display_name": "Intravascular microstructural, chemical and biomechanical characterization of coronary plaques", "description": "The most prevalent type of heart disease is caused by atherosclerosis, the thickening of the vessel wall and creation of atherosclerotic plaque. In this project, we will develop an imaging tool for the compre- hensive assessment of atherosclerotic plaque composition and vulnerability, with a clear pathway for translation into the clinical environment to enable the determination of the optimal treatment strategy in individual patients.", "funder_award_id": "5r01eb033306-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 552554.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2022-08-01", "end_date": "2026-04-30", "start_year": 2022, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10824318", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "NESTOR", "family_name": "URIBE-PATARROYO", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS GENERAL HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088354152", "display_name": "Improving Quality of Care for the Treatment of Childhood Pneumonia", "description": null, "funder_award_id": "5u01hd058322-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 879558.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2008-06-17", "end_date": "2013-05-31", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8290225", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PATRICIA L", "family_name": "HIBBERD", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS GENERAL HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088354377", "display_name": "HIT for Facilitating Problem Solving in Diabetes Management", "description": " The proposed HIT solution will be designed to help individuals with diabetes improve their problem-solving abilities, develop better self-care behaviors and improve their health. As such, this project has a high potential public health impact. ", "funder_award_id": "5r01dk090372-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 596712.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2011-09-06", "end_date": "2016-08-31", "start_year": 2011, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8541839", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GEORGE M", "family_name": "HRIPCSAK", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088355333", "display_name": "BIOMEDICAL COMPUTING SUPPORT FOR CANCER PREVENTION AND", "description": null, "funder_award_id": "n01cn075401-006", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "1987-09-30", "end_date": "1992-09-29", "start_year": 1987, "end_year": 1992, "landing_page_url": "https://reporter.nih.gov/project-details/3621842", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JANIS", "family_name": "BEACH", "orcid": null, "role_start": null, "affiliation": {"name": "INFORMATION MANAGEMENT SERVICES, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088356290", "display_name": "Re-Mind", "description": ""Two million older people need care in the UK. 400,000 live in care homes. 820,000 have a dementia diagnosis and many more are affected by it. Globally, 350m people need care and over 100m have dementia. The numbers are growing. \n\nReminiscence - including life story discussion - is a key technique to help protect precious memories. It gives carers and family a meaningful way to engage with their loved one. Old photos are an essential element but carers rarely know who the people in the photos are, or the family stories attached to them. Written notes can help but many people with dementia can no longer read. And dementia sufferers may destroy unadapted products however precious they are - ""fiddling"" is a part of the disease for many. The net result is a loss of connection to the past, to one's family and to one's self.\n\nCurrently every approach to reminiscence uses just one stimulus – sight. But we all know the joy of hearing family members’ voices; the uplifting power of hearing a beloved grandchild, child or spouse. And these voices are so rarely present for those in care. Family visits once a week, for the lucky ones. And when spouses pass away, their voices go with them.\n\nThe “Re-Mind” talking photo album is conceived by and for older people and those with dementia, their families and their carers. Each photo will be accompanied by voiceover from loved ones, telling the story of that photo. The voices in their own right will bring joy. By identifying the people, places and stories in the photo, the voiceover will help with both reminiscence and to sustain vital memories. Carers can use the resulting family history as a springboard for deeper and more meaningful conversations. And with the voiceover, many older people can use the album without relying on carer support.\n\nIn research, the concept has met with excitement amongst professional and family carers alike. This is not just a gap in the market, it is a whole new tool for delivering person-centred, joyful care.\n"", "funder_award_id": "753400", "funder": {"id": "https://openalex.org/F4320335087", "display_name": "Innovate UK", "doi": "10.13039/501100006041"}, "amount": 5000.0, "currency": "GBP", "funding_type": "voucher", "funder_scheme": null, "start_date": "2015-11-01", "end_date": "2016-04-29", "start_year": 2015, "end_year": 2016, "landing_page_url": "https://gtr.ukri.org/projects?ref=753400", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088356395", "display_name": "PGSA/ESA", "description": "No summary - Aucun sommaire", "funder_award_id": "198891-1997", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 5788.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Postgraduate Scholarships", "start_date": "1999-04-01", "end_date": "2000-03-31", "start_year": 1999, "end_year": 1999, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=198891-1997", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Kimble", "family_name": "Costain", "orcid": null, "role_start": null, "affiliation": {"name": "University of New Brunswick", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088360807", "display_name": "Novel Risk Factors For Hypertension", "description": null, "funder_award_id": "5k08hl079929-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 134730.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K08", "start_date": "2006-09-15", "end_date": "2011-06-30", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7642572", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN P", "family_name": "FORMAN", "orcid": null, "role_start": null, "affiliation": {"name": "BRIGHAM AND WOMEN'S HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088365796", "display_name": "Le rôle des médias numériques lors des inondations : stratégies de communication et d'utilisabilité pour alerter, informer et assister efficacement la population.", "description": null, "funder_award_id": "368768", "funder": {"id": "https://openalex.org/F4320331165", "display_name": "Fonds de recherche du Québec", "doi": "10.13039/501100020951"}, "amount": 40000.0, "currency": "CAD", "funding_type": "award", "funder_scheme": null, "start_date": "2025-05-15", "end_date": "2027-05-14", "start_year": 2025, "end_year": 2027, "landing_page_url": "https://repertoire.frq.gouv.qc.ca/offres/detailOffres.do?methode=consulter&demId=368768", "doi": "https://doi.org/10.69777/368768", "provenance": "crossref_work", "lead_investigator": {"given_name": "Laura", "family_name": "Lopes Jardim Agostini", "orcid": null, "role_start": "2025-05-15", "affiliation": {"name": "HEC Montréal", "country": null, "ids": [{"id": "https://ror.org/05ww3wq27", "type": "ROR", "asserted_by": "publisher"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088366268", "display_name": "HORMONE REGULATED GTP-BINDING PROTEINS", "description": null, "funder_award_id": "2r01dk037219-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1991-07-01", "end_date": "1999-11-30", "start_year": 1991, "end_year": 1999, "landing_page_url": "https://reporter.nih.gov/project-details/2140009", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN D", "family_name": "HILDEBRANDT", "orcid": null, "role_start": null, "affiliation": {"name": "MEDICAL UNIVERSITY OF SOUTH CAROLINA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088369744", "display_name": "Epigenetic Age Acceleration as a Biomarker of Early Life Adversity and Mid-life Cognitive Function", "description": "NARRATIVE Early life adversity affects two-thirds of all children in the U.S. and exerts a sustained impact on adult cognitive function. DNA methylation is a candidate mechanism for how early life adversity can be embedded biologically to elicit a sustained risk for impaired cognitive function across the lifespan. Epigenetic age, a measure of the biological age of human tissues and cells derived from DNA methylation, is sensitive to early life adversity and predictive of cognitive impairment and a worsening of neuropathological indices of Alzheimer's Disease in late- life. Establishing epigenetic age as a biomarker of early life adversity and cognitive function at mid-life can aid in the detection of those individuals at greatest risk for cognitive impairment in late-life.", "funder_award_id": "5r01ag059682-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 322910.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2018-09-15", "end_date": "2022-05-31", "start_year": 2018, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9939362", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHAD", "family_name": "SHENK", "orcid": null, "role_start": null, "affiliation": {"name": "PENNSYLVANIA STATE UNIVERSITY, THE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088370858", "display_name": "Children and their friends: experimental research investigating attachment and friendship", "description": null, "funder_award_id": "33045", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 17500.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Graduate Scholarships Program - Masters Scholarships", "start_date": "2005-04-01", "end_date": null, "start_year": 2005, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Coxhead, Amanda M.", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Calgary", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088371736", "display_name": "The Role of Glutamate in the Action of LSD", "description": null, "funder_award_id": "1f30da021048-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 29904.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F30", "start_date": "2007-03-05", "end_date": "2009-03-04", "start_year": 2007, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7221020", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DAVID J", "family_name": "LEE", "orcid": null, "role_start": null, "affiliation": {"name": "STATE UNIVERSITY OF NEW YORK AT BUFFALO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088376400", "display_name": "アーキアにおけるtRNA修飾システムの解明", "description": "アーキオシン生合成経路を、生化学的手法を用いて明らかにする試みの他に、分子遺伝学的手法も考慮に入れた実験を計画した。アーキアにおいて遺伝子破壊系が確立されているThermococcus kodakaraensisのTGT遺伝子と候補遺伝子のクローン化を試みた。T.kodakaraensisから染色体DNAを調製し、それを鋳型にPCRを行うことで両遺伝子断片を取得した。さらに、発現ベクターpET-11aに組込み、大腸菌内での大量発現を試みたところ、両タンパク質の可溶性画分への発現を確認できた。次に、大腸菌細胞抽出液を熱処理することで、両タンパク質の耐熱性を評価した。両タンパク質は熱処理後(85℃、15分間)の上清に存在していたことから、耐熱性を保持していると考えられた。熱処理後(75℃、15分間)の各上澄み液を用いて精製条件を決定した。TGTを、RESOURCE PHE、HiTrap DEAEFF、RESOURCE Qカラムに供することで精製した。候補タンパク質を、RESOURCE ETH、HiTrap DEAEFF、RESOURCE Qカラムに供することにより精製した。両タンパク質ともに、SDS-PAGEゲル上で単一バンド(CBB染色)になるまで精製することができた。今後、それぞれの酵素活性を確認していくとともに、TGTおよび候補遺伝子断片を用いて遺伝子破壊用プラスミドを構築し、遺伝子破壊株を作製する予定である。", "funder_award_id": "18658031", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3400000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Exploratory Research", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18658031/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "啓貴", "family_name": "東端", "orcid": null, "role_start": null, "affiliation": {"name": "Toyo University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020344864", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088380755", "display_name": "Development and Testing of ERE-Targeting Molecules for Breast Cancer Therapy", "description": null, "funder_award_id": "5r01ca129424-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 308434.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-04-01", "end_date": "2013-01-31", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8016087", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "NEIL", "family_name": "SIDELL", "orcid": null, "role_start": null, "affiliation": {"name": "EMORY UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088382602", "display_name": "AURASME", "description": "The EURORAA consortium is committed to stimulating high potential SMEs to enhance their innovation capacity and their managerial practices, in order to maximize their smart, sustainable and inclusive growth. The AURASME project is a subset of the COSME EURORAA consortium, based in the Rhône-Alpes and Auvergne regions in France. An integrated coordination within the existing activities in the work program of the EURORAA consortium is ensured. The partners involved are: Partner 1 (coordinator) CCIR Rhône-Alpes, Partner 2 ARDI Rhône-Alpes and Partner 4 CCIR Auvergne, so only Partner 3 (ERAI) of the consortium is not involved in this specific activity. \nHost organizations of the AURASME project have an expertise in key factors for the successful implementation of this activity: support of innovation projects, in particular within the framework of European projects; good knowledge and experience in European programs for SMEs; experience in promoting and supporting different management systems within SMEs (quality, security, environment, performance…); wide approach to several key aspects of innovation system and good knowledge of the high growth potential SMEs located in the Rhône-Alpes and Auvergne regions. \nThe general objective of this proposal is to bridge the gap of lacking innovation management capacities within the targeted SMEs located in Rhône-Alpes and Auvergne regions, in order to maximise the economic impact of ambitious innovation projects at European and International level. The work program is strictly focused on the objectives described in the call for proposal and on the implementation of the two required service packages: Key Account Management and Enhancing Innovation Management Capacity. \nThe Work Programme describes the implementation of these two packages services, the detailed methodology and process for both services and their expected impact. A close link is maintained with the present EEN COSME related work programme.", "funder_award_id": "674850", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 285384.75, "currency": "EUR", "funding_type": "grant", "funder_scheme": "H2020 - CSA", "start_date": "2015-01-01", "end_date": "2016-12-31", "start_year": 2015, "end_year": 2016, "landing_page_url": "https://cordis.europa.eu/project/id/674850", "doi": "10.3030/674850", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "CHAMBRE DE COMMERCE ET D'INDUSTRIEDE REGION AUVERGNE-RHONE-ALPES", "country": "FR", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088386563", "display_name": "The Intersection of Cutting-Edge Social Behavioral and Biomedical Strategies for", "description": null, "funder_award_id": "5r13mh081636-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 72454.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R13", "start_date": "2007-07-15", "end_date": "2012-05-31", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7624303", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY JANE", "family_name": "ROTHERAM-BORUS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408838736", "display_name": "Low-Power Parallel Computing on GPUs 2", "description": "Low-power GPUs have become ubiquitous, they can be found in domains ranging from wearable and mobile computing, to automotive systems. With this ubiquity has come a wider range of applications exploiting low-power GPUs, placing ever increasing demands on the expected performance and power efficiency of the devices. Future low-power system-on-chips will have to provide higher performance and be able to support more complex applications, without using any additional power.\n\nThe strict power limitations means that these demands cannot be met through hardware improvements alone, however, but the software must better exploit the available resources. Unfortunately, programmers are hindered when creating low-power GPU software by the quality of current performance analysis tools. In low-power GPU contexts there is only a minimal amount of performance information, and essentially no power information, available to the programmer. As software becomes more complex it becomes increasingly unmanageable for programmers to optimise the software for low-power devices.\n\nThis project proposes to aid the programmer in creating software for low-power GPUs by building on the results of the first LPGPU project to provide a complete performance analysis process for the programmer. This project will address all aspects of performance analysis, from hardware power and performance counters, to a toolchain that processes and visualises information from these counters, to applications that will be used as use-cases to drive the entire design. To access the new hardware performance counters a standardisable API will be produced to interface to a prototype hardware implementation. This will let the analysis and visualisation tool connect to any GPU driver that implements the API. The consortium's expertise will be used not only to drive the initial design of the API and analyses, but also multiple application use-cases will be developed to demonstrate the efficacy of the toolchain.", "funder_award_id": "688759", "funder": {"id": "https://openalex.org/F4320338475", "display_name": "H2020 LEIT Information and Communication Technologies", "doi": "10.13039/100010669"}, "amount": 2975787.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": "H2020-EU.2.1.1.", "start_date": "2016-01-01", "end_date": null, "start_year": 2016, "end_year": null, "landing_page_url": "https://cordis.europa.eu/project/id/688759", "doi": "http://dx.doi.org/10.3030/688759", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088387745", "display_name": "Experimentelle Untersuchung eines stochastischen Schätz und Segmentationsansatzes", "description": "Optische Flußfelder beschreiben die scheinbare Verschiebungsgeschwindigkeit von Grauwertstrukturen in Bildfolgen. Die Schätzung und Segmentation optischer Flußfelder ermöglichen die Detektion, Initialisierung sowie Verfolgung der Abbildungen von Objekten, z.B. zur Trajektorienbestimmung oder Kollisionsvermeidung. Gradientengestützte Ansätze zur Schätzung optischer Flußfelder beruhen auf der Extremisierung von Ausdrücken, bei der explizit oder implizit eine stochastische Unabhängigkeit der Komponenten geschätzter Grauwertgradienten unterstellt wird, die de facto nicht gegeben ist. Ein vom Antragsteller formulierter Ansatz überwindet diese grundlegende Schwierigkeit und sollte es dadurch ermöglichen, die Bestimmung bisher empirisch ermittelter Verfahrensparameter weitgehend auf Standardverfahren der Schätztheorie zurückzuführen. Untersuchungen der ersten Antragsphase ergaben allerdings, daß die jeweilige lokale Grauwertstruktur die Schätzergebnisse stärker als ursprünglich erwartet beeinflußt. Ein inzwischen entwickeltes adaptives Vorgehen trägt dem näherungsweise Rechnung. Die Schätz- und Segmentationsverfahren sind für -mit bewegter Kamera aufgenommene- Bildfolgen auszuweiten und abzusichern.", "funder_award_id": "5269769", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 549708.3269000001, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "1996-01-01", "end_date": "2001-12-31", "start_year": 1996, "end_year": 2001, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/5269769", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088389567", "display_name": "Funders Together to End Homelessness, Inc. - to provide for general operating support", "description": "to provide for general operating support", "funder_award_id": "INV-003277", "funder": {"id": "https://openalex.org/F4320306137", "display_name": "Bill and Melinda Gates Foundation", "doi": "10.13039/100000865"}, "amount": 50000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "U.S. Program", "start_date": "2019-10-01", "end_date": "2020-11-30", "start_year": 2019, "end_year": 2020, "landing_page_url": "https://www.gatesfoundation.org/about/committed-grants?q=INV-003277", "doi": null, "provenance": "gates_foundation", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "Funders Together to End Homelessness, Inc.", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088390265", "display_name": "Untitled", "description": null, "funder_award_id": "UI/BD/153627/2022", "funder": {"id": "https://openalex.org/F4320334779", "display_name": "Fundação para a Ciência e a Tecnologia", "doi": "10.13039/501100001871"}, "amount": 45719.7, "currency": "EUR", "funding_type": "grant", "funder_scheme": "FCT", "start_date": "2022-09-01", "end_date": "2026-08-31", "start_year": 2022, "end_year": 2026, "landing_page_url": "https://sciproj.ptcris.pt/86949DFA", "doi": "https://doi.org/10.54499/ui/bd/153627/2022", "provenance": "crossref_work", "lead_investigator": {"given_name": "Sara", "family_name": "Vieira da Cruz", "orcid": "https://orcid.org/0000-0002-9055-2858", "role_start": null, "affiliation": null}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088392482", "display_name": "COPPER METALLO BIOCHEMISTRY IN SACCHAROMYCES CEREVISIAE", "description": null, "funder_award_id": "5r01gm046787-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1992-05-01", "end_date": "1999-04-30", "start_year": 1992, "end_year": 1999, "landing_page_url": "https://reporter.nih.gov/project-details/2701550", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DANIEL J.", "family_name": "KOSMAN", "orcid": null, "role_start": null, "affiliation": {"name": "STATE UNIVERSITY OF NEW YORK AT BUFFALO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088393930", "display_name": "Peer Support--Congestive Heart Failure Self-Management", "description": null, "funder_award_id": "5r01hl085420-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 483831.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2006-08-01", "end_date": "2010-04-30", "start_year": 2006, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7263115", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY ELLEN MICHELE", "family_name": "HEISLER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088394354", "display_name": "HUMAN KUNITZ KALLIKREIN INHIBITOR THERAPY FOR ARTHRITIS", "description": null, "funder_award_id": "1r41ar045848-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R41", "start_date": "1999-09-10", "end_date": "2000-09-09", "start_year": 1999, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2794735", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERT W", "family_name": "COLMAN", "orcid": null, "role_start": null, "affiliation": {"name": "DYAX CORPORATION", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088396893", "display_name": "Not Available", "description": null, "funder_award_id": "CEECIND/00578/2017/CP1462/CT0002", "funder": {"id": "https://openalex.org/F4320334779", "display_name": "Fundação para a Ciência e a Tecnologia", "doi": "10.13039/501100001871"}, "amount": 259699.06, "currency": "EUR", "funding_type": "grant", "funder_scheme": "FCT", "start_date": "2019-06-11", "end_date": "2025-06-10", "start_year": 2019, "end_year": 2025, "landing_page_url": "https://sciproj.ptcris.pt/5070EEC", "doi": "http://dx.doi.org/10.54499/ceecind/00578/2017/cp1462/ct0002", "provenance": "crossref_work", "lead_investigator": {"given_name": "Paulo", "family_name": "Alexandre Lucas Afonso Condado", "orcid": "http://orcid.org/0000-0002-1176-1134", "role_start": null, "affiliation": null}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088398857", "display_name": "PRIMITIVE STEM CELL ISOLATION WITH MONOCLONAL ANTIBODIES", "description": null, "funder_award_id": "5r01dk033298-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1983-12-01", "end_date": "1989-11-30", "start_year": 1983, "end_year": 1989, "landing_page_url": "https://reporter.nih.gov/project-details/3231688", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERT GOFF", "family_name": "ANDREWS", "orcid": null, "role_start": null, "affiliation": {"name": "FRED HUTCHINSON CANCER RESEARCH CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408839974", "display_name": "The Role of Non-Canonical DNA Structures in Insulin Expression", "description": "The insulin-linked polymorphic region (ILPR) resides in the promoter region of the gene coding for insulin (INS). This region consists of a 14-base pair tandem repeat DNA sequence of 5'-ACAGGGGTGTGGGG-3'/3'-TGTCCCCACACCCC-5' and is located 363 base pairs upstream of the transcription start site of insulin. The insulin-linked polymorphic region can form non-canonical DNA secondary structures such as G-quadruplexes, i-motifs and hairpins. Previous work at the UCL School of Pharmacy has shown that different native insulin-linked polymorphic region sequence variants form different DNA structures and these result in differences in insulin gene transcription. \n\nThis project aims to reveal insights into the relationship between different DNA sequences in the insulin promoter region, the types of non-canonical structures they form, transcription of insulin and how this is influenced by small molecule ligands. The project will use biophysical approaches to determine the structure of different sequences in the insulin promoter, cell and molecular biology to understand the effects of different sequences and structures on insulin expression, including using small molecule ligands as probes. Finally, computational biology and x-ray crystallography will be used to design improved compounds that target the insulin-linked polymorphic region and switch on insulin transcription using structure-based rational design.", "funder_award_id": "101210737", "funder": {"id": "https://openalex.org/F4320338438", "display_name": "HORIZON EUROPE Marie Sklodowska-Curie Actions", "doi": "10.13039/100018694"}, "amount": 260347.92, "currency": "EUR", "funding_type": "grant", "funder_scheme": "HORIZON.1.2", "start_date": "2025-08-01", "end_date": null, "start_year": 2025, "end_year": null, "landing_page_url": "https://cordis.europa.eu/project/id/101210737", "doi": "https://doi.org/10.3030/101210737", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088399765", "display_name": "CELLULAR AND BIOCHEMICAL STUDIES OF CNS GLIA", "description": null, "funder_award_id": "7r01ns017125-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1989-07-01", "end_date": "1995-06-30", "start_year": 1989, "end_year": 1995, "landing_page_url": "https://reporter.nih.gov/project-details/3397368", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES E", "family_name": "GOLDMAN", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIV NEW YORK MORNINGSIDE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088401235", "display_name": "CONFORMATIONAL ANALYSIS OF RECEPTOR SELECTIVE OPIOIDS", "description": null, "funder_award_id": "5k02da000118-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K02", "start_date": "1989-09-30", "end_date": "1999-08-31", "start_year": 1989, "end_year": 1999, "landing_page_url": "https://reporter.nih.gov/project-details/2115945", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HENRY ISAAC", "family_name": "MOSBERG", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088401611", "display_name": "Statistical Qualification of the Impact of Missing Data in EMA Studies", "description": "PUBLIC HEALTH RELEVANCE: As the use of measurement-intensive methods, such as Ecological Momentary Assessment (EMA) methods, has become a new and vital approach to understanding health-related (e.g., smoking- and cancer- related) behaviors, there is a strong demand for developing appropriate analytic techniques for these new kinds of data and approaches to public health research. Like any study involving human subjects, missing data caused by nonresponse are ubiquitous in EMA studies and are often suspected to be nonignorable (e.g., when study participants' response behaviors to random prompts are related to contemporaneous but unobserved mood outcomes); unlike in more traditional studies, nonignorable missingness in such intensive data can pose significant new analytic challenges and calls for more general, flexible and tractable methods that are applicable in EMA studies to quantify and improve the reliability, validity and usability of the collected data. This proposal i aimed at addressing this need by developing principled and simple statistical measures and accessible software that allow researchers to conveniently quantify the robustness of empirical findings from studies using EMA or other types of measurement-intensive methods to nonignorable missingness for a wide range of data types and models, for complex missing data patterns and mechanisms and for studies that may involve a large number of analyses, and consequently facilitate more reliable understanding of the cancer- related health behaviors.", "funder_award_id": "5r01ca178061-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 286612.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2015-03-01", "end_date": "2020-02-29", "start_year": 2015, "end_year": 2020, "landing_page_url": "https://reporter.nih.gov/project-details/9437700", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HUI", "family_name": "XIE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ILLINOIS AT CHICAGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088402716", "display_name": "Addressing inequality, enhancing diversity and facilitating greater dialogue in the hosting of sporting mega events.", "description": "Major sporting events (MSEs) have been the subject of increasing levels of critique in recent years for the social costs associated with their bidding, planning and delivery. The rationale used by cities and countries for hosting MSEs is often the potential for an event to generate positive economic and social transformation within the host area (Brittain, Bocarro, Byers and Swart, 2017). However, research has repeatedly demonstrated actual impacts of hosting MSEs fall short of these lofty claims and in reality often result in detrimental effects for host populations. The negative impacts of MSEs have variously been reported as: exacerbating human rights abuses; facilitating corruption; supporting elite beneficiaries over those most in need; and transforming host destinations’ urban environment by displacing vulnerable populations. Recent mega sport events (a specific category of the largest MSEs, such as the Olympic Games and World Cup; Muller, 2015) have been the subject of international condemnation for being the catalyst for forced evictions (Beijing 2008; Rio de Janeiro, 2016), restricting media freedom through censorship (Sochi, 2014), abuse of migrant labour in the construction of facilities (Sochi, 2014; Qatar, 2022) and increased political repression (Beijing, 2008). Human Rights Watch has suggested that “Time after time, Olympic hosts have gotten away with abusing workers building stadiums, and with crushing critics and media who try to report about abuses…the right to host the Olympics needs to come with the responsibility not to abuse basic human rights” (Minky Worden, Director of Global Initiatives, HRW). The EventRights project will explore and produce recommendations as to how MSEs can influence MSE organizing committees and other stakeholders to ensure that progressive social opportunities to address inequality, enhance diversity and facilitate greater dialogue are enshrined in the planning, delivery and legacy plans for the events themselves.", "funder_award_id": "823815", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 772800.0, "currency": "EUR", "funding_type": "fellowship", "funder_scheme": "H2020 - MSCA-RISE", "start_date": "2018-12-01", "end_date": "2024-09-30", "start_year": 2018, "end_year": 2024, "landing_page_url": "https://cordis.europa.eu/project/id/823815", "doi": "10.3030/823815", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "TECHNISCHE UNIVERSITAET MUENCHEN", "country": "DE", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088403895", "display_name": "Computer-Programmed Models of Wholistic Integrated CognitiveSystems", "description": null, "funder_award_id": "7607333", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 67500.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1976-05-01", "end_date": "1979-08-31", "start_year": 1976, "end_year": 1979, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7607333", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Leonard", "family_name": "Uhr", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088407654", "display_name": "Roles of MNE's Headquarters and Subsidiaries on Global Innovation Strategies", "description": "This research aimed to get a better understanding of the MNE subsidiaries’ inter-organizational linkages. In the context of a NIS, the crucial actors in this study are MNE subsidiaries and local suppliers for technological innovative activity. Subsidiaries and suppliers are effectively interacting through forms of inter-organizational linkages; both have possible influences from inter-organizational linkages.This research contributes to discussions on the inter-organizational linkages in a host and neighboring countries by using data obtained in the South East Asian countries. Existing literature addressed and generalized the effectiveness of MNE subsidiaries in NIS; however, the evidence that industrial development in countries like the Philippines is proceeding in a different direction points out some limitations of existing literature.", "funder_award_id": "23730377", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4160000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": "2011-04-28", "end_date": "2015-03-31", "start_year": 2011, "end_year": 2015, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23730377/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Chie", "family_name": "IGUCHI", "orcid": null, "role_start": null, "affiliation": {"name": "Keio University(2012-2014)Rikkyo University(2011)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020411209", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088408550", "display_name": "Online PCP Training in Screening, Brief Intervention, Referral, and Treatment", "description": " Relevance This project meets the stated goal of the U.S. National Drug Control Strategy to facilitate the use of structured substance abuse screening, followed by brief interventions, and, if necessary, referral and treatment (SBIRT) by primary care physicians (PCPs). The Substance Abuse and Mental Health Services Administration (SAMHSA) currently sponsors several initiatives designed to improve PCP use of SBIRT, but these initiatives are based on a classroom teaching model. This proposal will develop a scalable, educationally effective SBIRT skills development program that can be nationally deployed and will better meet the needs of community PCPs and physicians in training.", "funder_award_id": "5r44da026218-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 165592.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R44", "start_date": "2009-01-01", "end_date": "2012-07-31", "start_year": 2009, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/8090267", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN MALCOLM", "family_name": "HARRIS", "orcid": null, "role_start": null, "affiliation": {"name": "MEDICAL DIRECTIONS, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088408946", "display_name": "BREATHE - The Health Data Research Hub for Respiratory Health Capital Award", "description": "What is the problem?\nEveryone in the UK will have a respiratory illness at some point in their life. We have the best datasets in the world – which should be used to improve respiratory health – but these are currently very difficult to find, access and use.\nWhat do we want to do?\nPeople in the UK deserve the best respiratory health. We want to make respiratory health better by changing the way the NHS, pharmaceutical companies, charities and researchers use data.\nHow will we do it?\nWe will continue to develop BREATHE (the health data research hub for respiratory health) where trained, approved experts can access respiratory data to benefit patients and the public. We will make it easier for experts to use data in safe and secure ways.\nHow will this benefit patients?\nBREATHE will support high quality research and cutting-edge innovation that will improve the lives of people living with respiratory conditions in the UK. It is important that patients and the public are involved with this project throughout, including from the very start. This is why there are patient and public members living with respiratory conditions who have worked with us on developing BREATHE and who are committed to delivering BREATHE’s goals.", "funder_award_id": "MC_PC_22006", "funder": {"id": "https://openalex.org/F4320334626", "display_name": "Medical Research Council", "doi": "10.13039/501100000265"}, "amount": null, "currency": "GBP", "funding_type": "intramural", "funder_scheme": null, "start_date": "2022-08-25", "end_date": "2023-03-30", "start_year": 2022, "end_year": 2023, "landing_page_url": "https://gtr.ukri.org/projects?ref=MC_PC_22006", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088412842", "display_name": "Development of a Diode-Array Microspectrophotometer", "description": null, "funder_award_id": "8600614", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 99929.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1986-05-01", "end_date": "1988-10-31", "start_year": 1986, "end_year": 1988, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8600614", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "James", "family_name": "Colacino", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088413044", "display_name": "Basic research to enable monitoring genome editing effects on dynamics of genetic information", "description": "In this study, we developed a universal probe in which non-specific endonuclease, MNase, that degrades genomic DNAs that proteins were not bound and protein A that binds to IgG antibodies specific to a genomic DNA-binding protein were covalently-crosslinked. Developed method using this universal probe (scChIC-Seq method) enabled tracking the genetic information regarding to the genomic DNA-binding proteins signals at the single-cell level (Nature Methods, 16, 323-325, 2019). We created probes that detect active histone-modified H3K4me3 and inhibitory histone-modified H3K27me3 signals, and demonstrated specificity and sensitivity of the developed probes to analyze epigenetic modification. In this study, the position and amount of genomic DNA-binding proteins motifs in genome-edited cells were comprehensively analyzed using this method.", "funder_award_id": "18K06679", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4420000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2018-04-01", "end_date": "2021-03-31", "start_year": 2018, "end_year": 2021, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K06679/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Kosuke", "family_name": "Nakamura", "orcid": null, "role_start": null, "affiliation": {"name": "National Institute of Health Sciences", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000060570926", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088413298", "display_name": "RETINAL GROWTH AND DIFFERENTIATION--EFFECT OF ONCOGENES", "description": null, "funder_award_id": "5r01ey006947-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1988-08-01", "end_date": "1991-07-31", "start_year": 1988, "end_year": 1991, "landing_page_url": "https://reporter.nih.gov/project-details/3263683", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARY F", "family_name": "NOTTER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ROCHESTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088415396", "display_name": "Systematic screen for the non-autonomous growth signal(s) originating in the fat body of Drosophila melanogaster larvae", "description": "In Drosophila larvae, the fat body acts as a signaling center. In response to the animal's nutritional status, it activates growth pathways that subsequently send out diffusible signals which promote the systemic growth. However, these fat body-derived signals identity remains unknown. To identify these signals, I will use the Gal4/UAS-system to systematically target Drosophila genes in the fat body, coupled with an enzyme-based assay to measure the effects on growth of peripheral organs. Importantly, this genetic screen will affect the pathway producing the secreted signals, thus potentially also allowing the identification of signals that are not peptides hormones.I therefore want to exploit Drosophila melanogaster as a model system to conduct the first systematic screen for signals and pathways that non-autonomously control tissue growth.", "funder_award_id": "145849", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 65900.0, "currency": "CHF", "funding_type": "fellowship", "funder_scheme": "Fellowships for prospective researchers", "start_date": "2013-02-01", "end_date": "2014-07-31", "start_year": 2013, "end_year": 2014, "landing_page_url": "https://data.snf.ch/grants/grant/145849", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Carreño,", "family_name": "Oriel", "orcid": null, "role_start": null, "affiliation": {"name": "Institution abroad", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088416124", "display_name": "Novel Strategy of PDE5-mTOR Inhibition in Attenuation of Cancer Drug Cardiotoxicity", "description": "Project Narrative Doxorubicin alone or its combination with kinase inhibitor are highly effective strategies for treatment of breast cancer but their utility is limited due to a major side effect involving heart failure. Currently there is no effective therapy available to reduce or eliminate the risk of heart failure in cancer patients treated with these agents. We propose to study a novel combination of phosphodiesterase 5 inhibitor, sildenafil (Viagra) and the potent anti-rejection drug, rapamycin to reduce cardiac side effects and improve the efficacy of breast cancer treatment with doxorubicin and doxorubicin with the kinase inhibitor.", "funder_award_id": "5r01hl158951-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 547243.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2022-07-01", "end_date": "2026-06-30", "start_year": 2022, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10632086", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANINDITA", "family_name": "DAS", "orcid": null, "role_start": null, "affiliation": {"name": "VIRGINIA COMMONWEALTH UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088416314", "display_name": "Video-recorded Interrogations: Beyond Camera Perspective", "description": "Abstract\r\n\r\nMany of the wrongful convictions that have been brought to light over the last two decades have their roots in the interrogation phase of criminal investigations where coerced or false confessions are sometimes extracted from detained crime suspects. A solution that has been widely recommended to help prevent this particular problem is to video record custodial interrogations in their entirety. Such a procedural modification indeed has the potential to improve the administration of justice; however, prudence calls for careful consideration of its possible pitfalls. Guided by basic psychological science, most notably the literature on illusory causation, Dr. G. Daniel Lassiter's more than 25 years of systematic investigation has empirically documented the existence of what is now commonly known as the camera perspective bias in video-recorded interrogations. That is, videos in which the camera directs observers visual attention onto suspects (rather than onto interrogators or equally onto suspects and interrogators) tend to produce more prejudicial evaluations of suspects, their statements are assessed as more voluntary, they are more likely to be judged guilty, and they receive more severe sentence recommendations. Importantly, Dr. Lassiter's research program also demonstrated that the advantages associated with video recording; for example, a more detailed record of the interrogation is provided to fact finders without introducing bias or undermining accurate assessments if an equal-focus perspective is taken by the video camera. \r\n\r\nAlthough it is clear that camera perspective is an important issue that any video-recording policy designed to protect the innocent should address, it is unfortunately not the only concern suggested by the behavioral science literature. The proposed research draws on four additional areas of psychological science to derive further potential limitations of video-recorded interrogations. A series of experiments are planned that will 1) determine the extent to which these hypothesized limitations would likely detrimentally influence actual fact finder evaluations of video-recorded interrogations, and 2) evaluate possible strategies for successfully counteracting them. An initial set of studies investigates the possibility that even an equal-focus video recording in certain circumstances may not fully protect minority suspects, due to what Dr. Lassiter and colleagues call a racial salience bias. A second set examines the potential judgment perseverance the defense must overcome to permit fact finders to correctly reinterpret a video interrogation that the prosecution, by virtue of trial convention, has the opportunity to first characterize as establishing a defendant's guilt. A third set focuses on the source monitoring errors fact finders may commit that could impede their ability to accurately conclude that a video-recorded confession narrative was actually contaminated by information provided by police earlier in the interrogation. A final set draws on construal level theory to test whether inducing an abstract (high) or concrete (low) level of mental construal prior to viewing video-recorded interrogations promotes more accurate assessments of a confession's reliability. \r\n\r\nThe proposed work will also yield clear research-based guidelines for legal practitioners and policy makers that will further improve the likelihood that the video-recording reform will fulfill its promise to minimize the possibility that an innocent person will be convicted based on an interrogation-induced false confession. In Dr. Lassiter's previously funded NSF projects, several graduate and undergraduate students were able to learn firsthand how basic psychological theory and research can give rise to scientific investigations that are of considerable practical import to the justice system and thus society more generally. Similarly, the proposed work will expose a new generation of students and future scholars to all phases of a programmatic research agenda that is simultaneously high in scientific rigor and immediate real-world applicability.", "funder_award_id": "1228258", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 189797.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2012-09-01", "end_date": "2016-08-31", "start_year": 2012, "end_year": 2016, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1228258", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "G. Daniel", "family_name": "Lassiter", "orcid": null, "role_start": null, "affiliation": {"name": "Ohio University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088417333", "display_name": "Genetics of Seizure Resistance: A Mutagenesis Strategy", "description": null, "funder_award_id": "5r21ns042328-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 220433.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2002-02-01", "end_date": "2006-01-31", "start_year": 2002, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6698550", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SCOTT C", "family_name": "BARABAN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA SAN FRANCISCO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088417334", "display_name": "Cellulosic ethanol", "description": "No summary - Aucun sommaire", "funder_award_id": "369541-2008", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4500.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "University Undergraduate Student Research Awards", "start_date": "2008-04-01", "end_date": "2009-03-31", "start_year": 2008, "end_year": 2008, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=369541-2008", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Caitlin", "family_name": "Cudmore", "orcid": null, "role_start": null, "affiliation": {"name": "University of Guelph", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088419062", "display_name": "Collaborative Research: Dynamical Tides in Close Stellar Binaries and Exoplanetary Systems", "description": "Tides are an important factor in many astrophysical settings. Tides can affect life, like tidal cycles on Earth; they can affect geology, as in the intense tidal pull of Jupiter on Io; and can even influence the evolution of stars in binary pairs. A research collaboration between Massachusetts Institute of Technology (MIT) and the University of Virginia (UVA) will analyze tidal friction in close star-star and star-planet binaries and assess the importance of nonlinear fluid dynamics on tides in these systems. Fluid dynamics is the science of how gases and liquids flow, and a nonlinear system is one in which the change in the output has a complicated (not simply linear) mathematical relationship with a change in the input. The principal investigators (PIs) have developed the basic theory and computational methods to study both weakly and strongly nonlinear tidal fluid dynamics. The proposed calculations will advance the state of the art in order to provide physics-based prescriptions for tidal friction over a range of stellar types, evolutionary stages, and degree of nonlinearity of the tide. The detailed calculations and numerical simulations will be distilled into simple prescriptions which may be useful for future investigations by astrophysicists. The MIT PI will serve as a research mentor in the study of tides to a student each year in the MIT Summer Research Program (MSRP). MSRP began as an MIT initiative to address the issue of underrepresentation of African Americans, Mexican Americans, Native Americans and Puerto Ricans in engineering and science in the US. It seeks to identify talented undergraduate students from US institutions who are underrepresented minorities and might benefit from spending a summer (nine weeks) at MIT working in a research group. The UVA PI will mentor undergraduate participants in the Virginia-North Carolina Louis Stokes Alliance for Minority Participation, which seeks to broaden participation of underrepresented minority populations in STEM disciplines.\r\n\r\nThree projects are proposed: (1) Orbital decay of hot Jupiters driven by weakly nonlinear wave-wave interactions. Previous work on solar-type stars will be expanded to include a range of stellar masses and evolutionary states. (2) Circularization and orbital decay in the strongly nonlinear limit, where wave breaking occurs for gravity waves. Again the goal is to expand previous calculations to the observed range of main sequence stars, as well as sub-giant and red giant branch stars. (3) Nonlinear wave interaction effects on the tide raised in the star and in the planet during high eccentricity planet migration. For each project, a detailed comparison of theoretical predictions to available data will be carried out. This includes close stellar binaries, the hot Jupiters and Neptunes around a variety of main sequence stars, and evolved stars with substellar companions.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "1909718", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 481538.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2019-07-15", "end_date": "2020-10-31", "start_year": 2019, "end_year": 2020, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1909718", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Nevin", "family_name": "Weinberg", "orcid": null, "role_start": null, "affiliation": {"name": "Massachusetts Institute of Technology", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088419683", "display_name": "Research Training in Age-Related Cognitive Disorders", "description": " This is a training program in age-related cognitive and neuropsychiatric disorders. The growing number of older persons who suffer from these conditions requires training young researchers in state-of-the-art approaches to these disorders, with a focus on integration and communication across disciplines. ", "funder_award_id": "5t32ag027668-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 321806.0, "currency": "USD", "funding_type": "training", "funder_scheme": "T32", "start_date": "2007-05-01", "end_date": "2017-04-30", "start_year": 2007, "end_year": 2017, "landing_page_url": "https://reporter.nih.gov/project-details/8459499", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARILYN S.", "family_name": "ALBERT", "orcid": null, "role_start": null, "affiliation": {"name": "JOHNS HOPKINS UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088421897", "display_name": "A multi-methodological approach to the instrumental phonetic and perceptual study of rhotic sounds in varieties of English.", "description": "Rhotics ('r'-sounds) have intrigued phoneticians perhaps more than any other class of consonants due to their phonetic complexity, diversity of articulation and susceptibility to rapid and extensive changes over time. This research will focus on the phonetics and phonology of rhotic sounds using a range of phonetic instruments and experimental methods, each of which addresses a different aspect of these sounds. Some look at how they are made in speakers' vocal tracts, some at their acoustic structures during transmission, and others at how they are perceived and processed by the brain. By combining methods that complement each other, this research hopes to paint a more complete picture of the different r-sounds in English and their similarities and differences than has been available until now. \\n Rhotic sounds are an important group of sounds in the world's languages for several reasons. They are important for phonetic and phonological theory because, while it is widely felt that they form a distinct class of sounds, it is far from clear what they all have in common, i.e. what defines the class of rhotic sounds. The class is generally held to include such phonetically different sounds as trilled 'r' produced with two or three beats of the tongue-tip against the upper gum, the French 'r-grasseye' produced with the back of the tongue, and the modern urban British English 'w'-like sound associated in the media with celebrities such as Jonathan Ross. The class of rhotics is thus seen to cut across the established classifications of traditional phonetic theory which is based on how sounds are made rather than how they are heard. This research will try to ascertain the relationship between the production and perception of these sounds, and whether the defining feature of the class of rhotics might be in the way they are perceived rather than in the way they are produced.\\n Rhotic sounds are important for developmental and clinical reasons because, no matter what language is being learned, children often find them the most difficult sounds to master in their acquisition of pronunciation systems and development of pronunciation skills. People with speech disorders often find that 'r' is one of the sounds most affected by their medical condition. The kinds of sounds that children and speakers with speech and/or hearing disorders produce in place of the 'correct' r-sound can provide insight into how r-sounds are represented in their speech production systems. The results of this research may prove useful for planning speech therapy intervention with populations affected by developmental and/or acquired speech and/or hearing disorders.\\n Rhotic sounds are important sociolinguistically because different social groups within the same language often have their own distinct form of r-sound which can function as a group identity-marker. For example, in French and German a back /r/ (articulated with uvular constriction) is considered socially prestigious, while a tapped or trilled /r/ is stigmatised. In English English, both uvular and trilled /r/ are non-standard and may elicit negative perceptions of the speaker. In Scottish English, by contrast, tapped/trilled /r/ is the socially acceptable norm. However, we do not know what the articulatory and acoustic thresholds are that have to be crossed before listeners perceive rhoticity, or how much variation there might be in these thresholds in different varieties of English. These questions are important for our understanding of the social significance of rhotics and have implications for forensic work in terms of speaker profiling and the evaluation of earwitness evidence where the rhoticity or non-rhoticity of a suspect's speech is at issue. \\n", "funder_award_id": "AH/J002151/1", "funder": {"id": "https://openalex.org/F4320334609", "display_name": "Arts and Humanities Research Council", "doi": "10.13039/501100000267"}, "amount": null, "currency": "GBP", "funding_type": "research", "funder_scheme": null, "start_date": "2011-09-30", "end_date": "2014-02-28", "start_year": 2011, "end_year": 2014, "landing_page_url": "https://gtr.ukri.org/projects?ref=AH/J002151/1", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088423342", "display_name": "Neurotensin: modulator of stress circuits", "description": null, "funder_award_id": "145062_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 6000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Canada Graduate Scholarships - Michael Smith Foreign Study Supplements", "start_date": "2015-04-01", "end_date": "2015-06-30", "start_year": 2015, "end_year": 2015, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Catherine", "family_name": "Normandeau", "orcid": null, "role_start": "2015-04-01", "affiliation": {"name": "University of North Carolina (Chapel Hill)", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088424018", "display_name": "Directed assembly of artificial mitotic spindles", "description": null, "funder_award_id": "5r21gm083297-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 176648.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2008-06-01", "end_date": "2011-05-31", "start_year": 2008, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7629067", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM OLAF", "family_name": "HANCOCK", "orcid": null, "role_start": null, "affiliation": {"name": "PENNSYLVANIA STATE UNIVERSITY, THE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088424550", "display_name": "STRUCTURES AND FUNCTIONS OF OLIGOSACCHARINS", "description": "STRUCTURES AND FUNCTIONS OF OLIGOSACCHARINS", "funder_award_id": "FG02-96ER20221", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 801750.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "OFFICE OF SCIENCE FINANCIAL ASSISTANCE PROGRAM", "start_date": "1996-08-20", "end_date": "2009-06-14", "start_year": 1996, "end_year": 2009, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_FG02-96ER20221_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088430477", "display_name": "Genetic control of meristem determinacy and organ fate", "description": null, "funder_award_id": "5f32gm082002-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 49646.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2007-07-01", "end_date": "2010-06-30", "start_year": 2007, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7477075", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BETH", "family_name": "THOMPSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA BERKELEY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408843062", "display_name": "The imaginary: cultural pedagogy, (non)normativity, and aesthetic play", "description": null, "funder_award_id": "83028", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 105000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Joseph-Armand Bombardier Canada Graduate Scholarships - Doctoral", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Ritchie, Nicole A.", "orcid": null, "role_start": null, "affiliation": {"name": "York University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088432020", "display_name": "GENETICS OF MURINE AIRWAY SODIUM ABSORPTION: ROLE IN CF", "description": null, "funder_award_id": "1r01hl064825-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 264707.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2000-04-01", "end_date": "2004-03-31", "start_year": 2000, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6091477", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MITCHELL L", "family_name": "DRUMM", "orcid": null, "role_start": null, "affiliation": {"name": "CASE WESTERN RESERVE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088434308", "display_name": "DISSERTATION RESEARCH: Integrating Molecular, Morphological, and Paleontological Data: Phylogeny, Diversification, and Character Evolution within the Pelecaniformes", "description": "An award has been made to the University of Chicago under the direction of Dr. Peter J. Makovicky to study the evolution and systematics of the Pelecaniformes (pelicans, cormorants, and other large water birds). The project will improve the doctoral dissertation research of Nathan D. Smith. This group of birds is an ideal model for the study of living and fossil species. This group of birds exhibits an exceptional fossil record and remarkably disparate morphologies, but their evolutionary relationships are poorly known. This project will unite data from molecules, morphology, and paleontology to examine evolutionary patterns within Pelecaniformes. Morphology and DNA data will be used to resolve phylogenetic relationships, and a synthesis of the fossil record will elucidate relationships of key fossil taxa. These data will be used to investigate the sensitivity of molecular dating methods, compare relationships supported by molecular genetic data with those of the fossil record, and explore rates of evolution and potential cases of morphological convergence.\r\n\r\nThis research has broader implications for issues of dataset combination and divergence time estimation in systematic biology. This study will also educate the public about paleontology, evolution, and biodiversity. Results will be used to update exhibits of fossil birds in the Field Museum of Natural History. Smith will collaborate with the FMNH to enhance explanatory material accompanying the Harris Educational Loan Program, and to create programming for the Illinois High School Transformation Project that focuses on paleontology and evolution.\r\n", "funder_award_id": "0808250", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 11800.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2008-07-01", "end_date": "2011-06-30", "start_year": 2008, "end_year": 2011, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808250", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Peter", "family_name": "Makovicky", "orcid": null, "role_start": null, "affiliation": {"name": "University of Chicago", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088436608", "display_name": "ROLE OF VIL-6 IN PRIMARY EFFUSION LYMPHOMAS", "description": null, "funder_award_id": "3r01ca083519-03s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 9393.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2000-07-01", "end_date": "2005-06-30", "start_year": 2000, "end_year": 2005, "landing_page_url": "https://reporter.nih.gov/project-details/6763962", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN", "family_name": "NICHOLAS", "orcid": null, "role_start": null, "affiliation": {"name": "JOHNS HOPKINS UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088439565", "display_name": "National Governors Association Center for Best Practices - to work with state policymakers on the implementation of the Common Core State Standards, with special attention to effective resource reallocation...", "description": "to work with state policymakers on the implementation of the Common Core State Standards, with special attention to effective resource reallocation to ensure complete execution, as well as rethinking state policies on teacher effectiveness", "funder_award_id": "OPP1031294", "funder": {"id": "https://openalex.org/F4320306137", "display_name": "Bill and Melinda Gates Foundation", "doi": "10.13039/100000865"}, "amount": 1293904.0, "currency": "USD", "funding_type": "training", "funder_scheme": "Global Policy and Advocacy|U.S. Program", "start_date": "2011-02-01", "end_date": "2013-09-01", "start_year": 2011, "end_year": 2013, "landing_page_url": "https://www.gatesfoundation.org/about/committed-grants?q=OPP1031294", "doi": null, "provenance": "gates_foundation", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "National Governors Association Center for Best Practices", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088439718", "display_name": "Post-pandémie: austérité, relance ou transition?", "description": null, "funder_award_id": "84430", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 25000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Connection Grants", "start_date": "2021-04-01", "end_date": null, "start_year": 2021, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Tremblay-Pepin, Simon", "orcid": null, "role_start": null, "affiliation": {"name": "Saint Paul University", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088439956", "display_name": "Geochemistry of Ore Depositing Fluids by Analysis of Fluid Inclusion Gases and Geologic Studies", "description": null, "funder_award_id": "8410481", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 126400.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1984-11-15", "end_date": "1987-04-30", "start_year": 1984, "end_year": 1987, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8410481", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "David", "family_name": "Norman", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088441519", "display_name": "Doctoral Dissertation Research: Clarifying Survey Questions", "description": "Although comprehension is well recognized as a critical component of the survey question response process, much about it remains unknown. Past research has shown that ambiguous or vague concepts can be clarified through the use of definitions, instructions, or examples, but respondents do not necessarily attend to these clarifications. The aim of this doctoral dissertation research project is to investigate where and how to present clarifying information so that respondents will recognize it as essential to their answering survey questions correctly. A key issue is whether sensory channels (aural versus visual) make different demands on comprehension. The answer to this question is largely unknown, because sensory channel is often confounded with the presence of an interviewer in so many of the relevant studies. This project will help to establish whether respondents anticipate the end of a question and are more likely to interrupt clarifying information that is placed after a question than before and whether this harms survey estimates. It will help to confirm whether incorporating the clarifications into the questions and asking a series of simpler questions, as suggested by many researchers, is even more effective. Finally, understanding will be gained regarding whether respondents are better at comprehending complex clarifications in the visual channel than the aural, and whether channel interacts with the method of clarification.\r\n\r\nThe goal of this project, to gain a better understanding of how to reduce ambiguity and vagueness in survey questions across survey modes, is especially relevant given the current debate over how to design questions for mixed-mode surveys. This project has the potential to lead to more accurate survey estimates, to better descriptions of the nation based on survey data, and to better decision-making policies. As a Doctoral Dissertation Research Improvement award, support is provided to enable a promising student to establish a strong independent research career. The project is supported by the Methodology, Measurement, and Statistics Program and a consortium of federal statistical agencies as part of a joint activity to support research on survey and statistical methodology.", "funder_award_id": "1024244", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 12000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2010-09-01", "end_date": "2011-08-31", "start_year": 2010, "end_year": 2011, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1024244", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Stanley", "family_name": "Presser", "orcid": null, "role_start": null, "affiliation": {"name": "University of Maryland, College Park", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408844265", "display_name": "CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE", "description": "PUBLIC HEALTH RELEVANCE: Disorders of breathing during sleep, including sleep apnea, have emerged as independent risk factors for stroke, especially silent strokes. The proposed studies will advance our understanding of the pathophysiological substrates underlying the increased susceptibility to ischemic injury in sleep apnea. Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition.", "funder_award_id": "5r01ns073666-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 369688.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2011-04-01", "end_date": "2016-02-29", "start_year": 2011, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8790470", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "COSTANTINO", "family_name": "IADECOLA", "orcid": null, "role_start": null, "affiliation": {"name": "WEILL MEDICAL COLL OF CORNELL UNIV", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088445548", "display_name": "Compressed All-optical Photoacoustic Imaging of Neuronal Activity", "description": "To decipher the numerous complex brain functions, it is desirable to measure the electrical activity of large sets of neurons. However, there is currently no technique to image non-invasively this activity deep inside the brain (> 2 mm) with single-cell resolution (10um), high frame rate (>10 Hz). This project aims at developing an all-optical photoacoustic imaging system to solve this challenge, and demonstrate its performances at unprecedented depths in the mouse brain. This technique is based on the optical interferometric measurement of ultrasounds generated upon the absorption of a short laser pulse by an optical absorber. In order to detect high acoustic frequencies (up to 100 MHz) and hence reach single-cell resolution, I will fabricate thin Fabry-Pérot cavities with a polymer sensing layer inserted between two mirrors. To speed up the acquisition, I will develop acquisition strategies and corresponding imaging reconstruction algorithms based on compressive sensing. Combined to a semi-parallelized acquisition using a photodiode array, it will ensure a high frame rate of more than 10 Hz. This project will be paving the way toward neuronal activity imaging at large depth (>2 mm) in the mouse brain, with cellular spatial resolution and high temporal resolution.", "funder_award_id": "ANR-23-CE42-0003", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 259870.74, "currency": "EUR", "funding_type": "research", "funder_scheme": "AAPG2023", "start_date": "2024-02-29", "end_date": null, "start_year": 2024, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-23-CE42-0003", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Thomas", "family_name": "CHAIGNE", "orcid": "https://orcid.org/0000-0001-7611-3587", "role_start": null, "affiliation": {"name": "Institut Fresnel Marseille", "country": "France", "ids": [{"id": "201220335F", "type": "rnsr", "asserted_by": "anr"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088451793", "display_name": "MRI & CT studies of the developing vocal tract", "description": " Imaging and acoustic methods are used to provide detailed information on the typical and atypical anatomic development of the vocal tract. The data will establish normative references that inform sex- and age-specific modeling of the vocal tract and provide a foundation for intervention strategies that are designed to modify developmental patterns in anatomy, physiology, or acoustic output. The information to be obtained is central to the needs of several clinical specialties concerned with behaviors such as feeding, swallowing, speech production, and respiration; also, the data can be used to test prevailing theories on craniofacial development.", "funder_award_id": "2r01dc006282-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 643713.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-08-01", "end_date": "2019-06-30", "start_year": 2003, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8632679", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HOURI KALOUSTIAN", "family_name": "VORPERIAN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WISCONSIN-MADISON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408845354", "display_name": "Social Mobile Approaches to Reduce Weight (SMART) 2.0", "description": "PROJECT NARRATIVE There is a critical need to advance our understanding of how to develop and deploy multimodal, technology- based weight-loss interventions that have the potential for long-term effects and widespread dissemination among university students. Intervention content that promotes weight loss through increased energy expenditure, decreased energy intake, and adequate sleep will be delivered using a fully integrated system of modalities: 1) Fitbit, 2) MyFitnessPal, 3) SMS, 4) multiple social media streams, 5) a website with blog, and 6) email. The intervention is designed to maximize efficacy in a scalable manner, and by measuring usability and acceptability, this study will inform intervention dissemination to campus health centers and wellness programs should the findings warrant it.", "funder_award_id": "1r01hl136769-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 747494.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2018-02-19", "end_date": "2023-01-31", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/9449133", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOB GIDEON", "family_name": "GODINO", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA, SAN DIEGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088453829", "display_name": "Interdisciplinary Research Training in Speech-Language Disorders", "description": null, "funder_award_id": "5t32dc005359-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 239370.0, "currency": "USD", "funding_type": "training", "funder_scheme": "T32", "start_date": "2002-07-01", "end_date": "2013-06-30", "start_year": 2002, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7615012", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SUSAN", "family_name": "ELLIS-WEISMER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WISCONSIN-MADISON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088454", "display_name": "Basic research on detection of task errors in robotic manipulation", "description": "A dexterous manipulation system has been developed as a test bed for detecting errors of task : the system is conposed of a multi-fingered hand equipped with force/torque sensors on each fingertips, a 3-D realtime stereo vision to measure the pose of a manipuiated object, and a realtime figer controller.Following functions have been developed :(1).The grasped object is manipulated through rolling contacts between fingertips and the surface of the object enabling fine and control with 10ms of servo cycle time.(2).The 3-D stereo vision measures the pose the pose of the grasped object in every 33ms.(3).A method of separating internal forces and external forces from the force/torque sensorsigna1s has been developed. The former is necessary for the stable grasp and the latter is required for desired manipulation of the object.Detection of task errors requires online reasoning of how the task is being executd. This reasoning is made by combining the higher level synbolic meaning of the task and the lower level motion of fingers and the manipulated object. To enable the reasoning, motion primitives of the multi-fingered hand for mechanical assembly have been developed. Peg-insertion, screw-insertion, and screw-rotation have been successfully implenented as motion primitives.In the mechanical assenbly experinents by multi-fingered hand, a slip is very often caused at the contact of the fingertip and the manipulated object mainly because of an unpredictab1e friction force in the assenbly. This slip leads to an error of the task. For the error detection and recovery, a task monitoring system has been developed using the real time 3-D vision. This is implemented as a parallel process with the task execution control process. Detection of errors in the pose of the manipulated object in a minimum time delay without losing fine and dexterous manipu1ation capability.", "funder_award_id": "08650495", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2000000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-08650495/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Tsutomu", "family_name": "HASEGAWA", "orcid": null, "role_start": null, "affiliation": {"name": "KYUSHU UNIVERSITY", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000243890", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088454618", "display_name": "Electrical Impedance Myography in an Animal Model", "description": null, "funder_award_id": "1r01ns055099-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 356563.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2007-08-01", "end_date": "2012-04-30", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7314555", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SEWARD B", "family_name": "RUTKOVE", "orcid": null, "role_start": null, "affiliation": {"name": "BETH ISRAEL DEACONESS MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088456077", "display_name": "RELATIVE DENSITY OF SANDS BY CONE PENETROMETER TEST- ING", "description": null, "funder_award_id": "7355917", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1973-01-01", "end_date": "1975-01-01", "start_year": 1973, "end_year": 1975, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7355917", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088460551", "display_name": "Mechanical Proving in Geometries", "description": null, "funder_award_id": "8503498", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 82600.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1985-06-01", "end_date": "1987-11-30", "start_year": 1985, "end_year": 1987, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8503498", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Robert", "family_name": "Boyer", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088462785", "display_name": "Clinical Trials of Immunotherapies for Childhood Cancer", "description": null, "funder_award_id": "1ziabc011498-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1113902.0, "currency": "USD", "funding_type": "intramural", "funder_scheme": "ZIA", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/8938161", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CRYSTAL", "family_name": "MACKALL", "orcid": null, "role_start": null, "affiliation": {"name": "DIVISION OF BASIC SCIENCES - NCI", "country": null, "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088469283", "display_name": "Complement and Pathogenic Mechanisms of AMD", "description": " Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the sixty-five-and-older population, and the devastating impact of its socioeconomic burden cannot be overstated. Using mouse models that faithfully recapitulate many aspects of human AMD, we have demonstrated that observed ocular defects arise from inflammation, amyloid beta (A¿) deposition and complement dysregulation - mechanisms implicated in development of human AMD. Our proposed studies will further clarify the contribution of complement and A¿ to disease onset and progression. Validation of A¿ as a novel therapeutic target in AMD could lead to a fundamental paradigm shift in the understanding and treatment of AMD. Moreover, unraveling the impact of excess complement activation versus increased complement inhibition on subRPE deposit formation and RPE damage will help shape the development of complement-targeted therapies that could delay or prevent AMD. Finally, elucidating which constituents of the posterior eye extracellular matrix regulate complement should provide additional novel AMD therapy targets. ", "funder_award_id": "2r01ey019038-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 392500.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-08-01", "end_date": "2012-08-31", "start_year": 2009, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/8188337", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CATHERINE", "family_name": "BOWES RICKMAN", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088470728", "display_name": "The roles of arachidonic acid metabol in the pathogenesis of inflammatory diseases in childhood: Regulation of related enzymes by various cytokines", "description": "A series of enzymes which are responsible for the synthesis of prostaglandins(PGs), thromboxane(TX) and leukotriens(LTs) are activated in a variety of allergic and inflammatory disease in childhood. One of the possible regulatory mechanisms is a transcriptional up-regulation by various cytokines and inflammatory mediators at the transcriptional and/or translational levels of each enzyme. In this study, we have investigated up-regulatory mechanisms of cytosolic PLA2, cyclooxygenase(COX)-1, COX -2, 5-lipoxygenase (5-LO), LTC4 synthase (LTC4syn), LTA4 hydrolase and 5-LO activating protein (FLAP) in PMNs and HL-60 cells by using RT-PCR and Northern blotting techniques. In PMNs, the synthesis of LTB4 and TXB2 was increased by the stimulation with IL-3 and GM/CSF for 30-60 min, the production was then decreased. After several hours, the synthesis of TXB2 but not LTB4 was increased again, which was associated with enhanced expression of COX-2 mRNA. IL-8 temporarily increased the synthesis of LTB4 after 60 min stimulation, indicating a priming effect on 5-LO or LTA4 hydrolase. LTB4 synthesis was enhanced by IL-4 and IL-13 after 6 hour incubation, which was associated the enhanced expression of LTA4 hydrolase mRNA. Lipopolysaccharide(LPS), a bacterial endotoxin, increased the production of TXB2 by new induction of cPLA2 and COX-2 in PMNs. In DMSO-treated HL-60 cells, the synthesis of LTB4 and LTC4 was increased by transcriptionaly up-regulating 5-LO, LTC4syn and LTA4 hydrolase. We also investigated how anti-inflammatory and anti-allergy medicines modulate these enzyme activities.", "funder_award_id": "09670816", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1600000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09670816/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yuhei", "family_name": "HAMASAKI", "orcid": null, "role_start": null, "affiliation": {"name": "Saga Medical School", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010172967", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088471998", "display_name": "Clarification of pathophysiology of peri-implantitis based on macrophages and osteocyte autophagy", "description": "歯科インプラント治療は欠損歯列の回復に有効な治療選択肢のひとつであるが，インプラント周囲炎という歯周病に似た疾患が最近問題となっている．しかしその原因はよくわかっていないのが現状である．この研究はインプラント周囲炎をラットに引き起こして詳細に状態を調べることにより，インプラント周囲炎の発生メカニズムを明らかにしようとする試みである．", "funder_award_id": "20K18608", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4160000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Early-Career Scientists", "start_date": "2021-02-01", "end_date": "2024-03-31", "start_year": 2021, "end_year": 2024, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K18608/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Nao", "family_name": "INABA", "orcid": null, "role_start": null, "affiliation": {"name": "Nagasaki University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000814170", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088475343", "display_name": "Salivary Biomarkers for Early Oral Cancer Detection", "description": null, "funder_award_id": "5r01de017170-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 332745.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-04-01", "end_date": "2013-03-31", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8044142", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DAVID T", "family_name": "WONG", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088478232", "display_name": "Cognitive-affective Mechanisms of Food Biases Trainings", "description": "Food bias; Cognitive bias modification; Approach-Avoidance Tasks", "funder_award_id": "P 34542", "funder": {"id": "https://openalex.org/F4320321181", "display_name": "Austrian Science Fund", "doi": "10.13039/501100002428"}, "amount": 404754.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Einzelprojekte", "start_date": "2021-10-01", "end_date": "2026-06-30", "start_year": 2021, "end_year": 2026, "landing_page_url": "https://fwf.ac.at/forschungsradar/10.55776/P34542", "doi": "10.55776/p34542", "provenance": "openaire_fwf", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088480255", "display_name": "HS1 Function in Dendritic Cells", "description": null, "funder_award_id": "1f32ai080069-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 18387.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2009-09-01", "end_date": "2010-01-31", "start_year": 2009, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7673160", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DEBORAH A.", "family_name": "KLOS DEHRING", "orcid": null, "role_start": null, "affiliation": {"name": "CHILDREN'S HOSP OF PHILADELPHIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088481806", "display_name": "MEMBRANE PROTEIN SORTING IN POLARIZED CELLS", "description": null, "funder_award_id": "5r01dk050825-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1996-09-15", "end_date": "2000-07-31", "start_year": 1996, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2749591", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "IAN S", "family_name": "TROWBRIDGE", "orcid": null, "role_start": null, "affiliation": {"name": "SALK INSTITUTE FOR BIOLOGICAL STUDIES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088486205", "display_name": "ALDOSTERONE: GENETIC REGULATION AND VASCULAR REACTIVITY", "description": null, "funder_award_id": "5k23hl004221-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 145287.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2000-05-22", "end_date": "2005-04-30", "start_year": 2000, "end_year": 2005, "landing_page_url": "https://reporter.nih.gov/project-details/6388627", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES V", "family_name": "GAINER", "orcid": null, "role_start": null, "affiliation": {"name": "VANDERBILT UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088487196", "display_name": "INITIAL LESION OF ADULT PERIODONTITIS", "description": null, "funder_award_id": "5r01de009513-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1992-03-15", "end_date": "1996-03-14", "start_year": 1992, "end_year": 1996, "landing_page_url": "https://reporter.nih.gov/project-details/3223255", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANNE C", "family_name": "TANNER", "orcid": null, "role_start": null, "affiliation": {"name": "FORSYTH INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088490396", "display_name": "Validating a mouse model of ovarian cancer for early detection through imaging", "description": "PUBLIC HEALTH RELEVANCE: There is currently no acceptable screening method for ovarian cancer, and most cases are detected when the disease is widespread and likely to be deadly. We propose to develop and validate a novel, post-menopausal mouse model of ovarian cancer, and to use this model to discover image markers of early disease. These markers can be translated into an imaging system that enables early detection of ovarian cancer and saves lives. ", "funder_award_id": "1r01ca195723-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 572656.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2015-09-01", "end_date": "2017-08-31", "start_year": 2015, "end_year": 2017, "landing_page_url": "https://reporter.nih.gov/project-details/8902450", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JENNIFER KEHLET", "family_name": "BARTON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ARIZONA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088493104", "display_name": "CELL ADHESION MOLECULE UPREGULATION IN IBD", "description": null, "funder_award_id": "5k08dk002128-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K08", "start_date": "1993-05-01", "end_date": "1998-04-30", "start_year": 1993, "end_year": 1998, "landing_page_url": "https://reporter.nih.gov/project-details/2133868", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CIARAN P", "family_name": "KELLY", "orcid": null, "role_start": null, "affiliation": {"name": "BETH ISRAEL DEACONESS MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088494214", "display_name": "The role of autophagy in inflammatory bowel disease-associated colorectal cancer", "description": "Canada has amongst the highest rates of inflammatory bowel disease (IBD) in the world. IBD is a condition that damages the intestine, resulting in debilitating symptoms such as pain, diarrhea and bleeding. Individuals with IBD have an increased risk of developing colorectal cancer, which correlates with the length of time they have disease. In fact, due to this increased risk, doctors recommend that people with IBD undergo once or twice yearly colonoscopies to screen for cancer. However, we don't know why people with IBD get cancer. Recent studies suggest that a cellular process called autophagy may be involved. Autophagy is a cell recycling system that removes and breaks down old and damaged cellular components to provide the cell with raw materials to make new parts. It is also important in getting rid of bacteria that invade our cells. When autophagy is defective, cells accumulate components that don't function properly and this can contribute to the development of diseases such as IBD and cancer. On the other hand, once a tumor has developed, autophagy may promote its survival in the same way it facilitates normal cell survival, by removing damaged material. Our research will test the idea that defective autophagy increases the chance of getting colorectal cancer when you have IBD. We will also test the idea that defective autophagy may help limit tumor size and progression after a tumor has been established. To do this I will cause IBD in normal mice and in mice that are unable to carry out autophagy in their intestine. I will give the two groups of mice a drug to increase the development of colorectal cancer. I will then determine if the mice without autophagy develop cancer more quickly and evaluate how autophagy affects tumor size after cancer has developed. If we determine that autophagy contributes to colorectal cancer initiation and progression in individuals with IBD, this will open the door for new treatments that specifically target this pathway.", "funder_award_id": "141050_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 42000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Fellowship - Priority Announcement - Inflammatory Bowel Disease", "start_date": "2015-04-01", "end_date": "2017-06-26", "start_year": 2015, "end_year": 2017, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Laura", "family_name": "Greenfield", "orcid": null, "role_start": "2015-04-01", "affiliation": {"name": "Hospital for Sick Children (Toronto)", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408849519", "display_name": "REIMBURSE THE STATE OF UTAH FOR COSTS INCURRED IN THE PERFORMANCE OF THE FEDERAL FACILITIES AGREEMENT (FFA)", "description": "REIMBURSE THE STATE OF UTAH FOR COSTS INCURRED IN THE PERFORMANCE OF THE FEDERAL FACILITIES AGREEMENT (FFA)", "funder_award_id": "FG01-89ID12849", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 124574.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "INDUSTRIAL ENERGY CONSERVATION", "start_date": "1989-06-16", "end_date": "2007-07-30", "start_year": 1989, "end_year": 2007, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_FG01-89ID12849_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088496259", "display_name": "The mechanism of development and exacerbation of virus-induced asthma analyzed by a lipid mediator gene knock-out mice", "description": "To clarify the pathogenesis of exacerbations of asthma due to viral infection, we examined bronchial resistance, peripheral blood and bronchial alveolar fluid (BALF) analyses and multiple types of cytokines/chemokines using an experimental asthma model mice infected with respiratory syncytial virus (RSV). The levels of BALF and tissue eosinophils showed significant increase in ovalbumin (OVA) and OVA/RSV groups compared with controls. MIP-1αin BALF was significantly increased in OVA/RSV groups compared with RSV groups, OVA groups, and control groups. Serum IL-5 in OVA groups and serum IL-17 in OVA/RSV groups were also higher than in controls. These findings suggest that eosinophilic inflammation via MIP-1α may play an important role in acute exacerbations of asthma model induced by RSV.", "funder_award_id": "20591267", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20591267/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Masahiko", "family_name": "KATO", "orcid": null, "role_start": null, "affiliation": {"name": "Gunma Institute of Public Health and Environmental Sciences", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030292593", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088497598", "display_name": "Molecular mechanisms of interplay between ethylene signaling and chromatin regulation in Arabidopsis", "description": "PUBLIC HEALTH RELEVANCE: Signaling systems regulate the cell events responsible for survival, development and homeostasis. Malfunction of signaling circuits causes many diseases, such as cancer. Nuclear enzymes, chromatin and its modifications contribute to the abilities of cells and organisms to respond and survive in dynamic environments. Dysfunctions nuclear processes contribute directly to cancer progression and genetic disorders. The research proposed here to study the communication between signaling and chromatin regulation has the potential to provide an important basis to the effort of developing novel strategies for finding ne drugs.", "funder_award_id": "5r01gm115879-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 298375.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2015-08-01", "end_date": "2020-09-10", "start_year": 2015, "end_year": 2020, "landing_page_url": "https://reporter.nih.gov/project-details/9690158", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HONG", "family_name": "QIAO", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TEXAS AT AUSTIN", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088497605", "display_name": "A study for dissemination of advising in language learning in Japan", "description": "For dissemination of advising in language learning (ALL) in Japan, the final goal of the principal investigator aims to (1) develop a semi-structured ALL program, (2) create an advisor training program, and (3) insert ALL-related experiences into English teacher training processes. As an intermediate step for these three purposes, this study (1) developed a schematic model of a semi-structured ALL program that enables advisors to offer a more effective ALL service, (2) created a training program kit that includes both theoretical and practical aspects, and (3) found significant changes in beliefs of pre-service English teachers who participated in this study as an advisor.", "funder_award_id": "17H07173", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2860000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Research Activity Start-up", "start_date": "2017-08-25", "end_date": "2019-03-31", "start_year": 2017, "end_year": 2019, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17H07173/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Toshinori", "family_name": "Yasuda", "orcid": null, "role_start": null, "affiliation": {"name": "Waseda University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030802087", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088501113", "display_name": "Research on Improving the Menus of Meal Delivery Service for the Elderly", "description": "The purpose of this research was to improve the menus of meal delivery services provided by local governments for the elderly. At first, hearing survey was conducted of 13 local government officers in charge of the service. As for the nutritional standard was numerically defined by some governments, but not by others where the menus of nursing home are used. Next, basic investigation was conducted of all local governments in Fukuoka Prefecture. Most of the local governments aimed to offer well-balanced meal, but not checked the menus and the real meal. Therefore a check sheet easily routinely was proposed as menu evaluation method which was consisting of the viewpoints of \"nutrition and food configuration\", \"food materials and production\", \"taste of the dishes\".", "funder_award_id": "23500881", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4940000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2011-04-28", "end_date": "2016-03-31", "start_year": 2011, "end_year": 2016, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23500881/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yuko", "family_name": "AKINAGA", "orcid": null, "role_start": null, "affiliation": {"name": "Fukuoka University of Education", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070167948", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088504512", "display_name": "Cooperation of Food Manufacturing Industry and Domestic Agriculture in Japanese Food System", "description": "In fiscal year 2003, we conducted the following research projects. First, we investigated the vertical integration of poultry industry, including brand management, the coordination of production system and the relationship to local agro-food system. Second, we investigated the food system of wheat flours. We explained the detailed relationship among milling industry, bread and noodle manufacturers and retailers. The coordination between domestic wheat producers and small-scale millers was also investigated. Third, We investigated the marketing strategy of fruits and vegetables producers and made clear the future strategy for agro-cooperatives and the management system of marketing channels including farmers' markets. We also conducted a case study of some agricultural production corporations.Results of this research project were released as follows. First, four articles concerning poultry industry were published. Second, one book concerning the food system of wheat flour products was published, including various topics such as bread manufacturers, noodle manufacturers, vertical integration of milling industry and the strategy for small-scale millers and domestic wheat producers. Third, we published some papers and articles about the food system of fruits and vegetables, which mainly explains the importance of developing direct marketing channels and their management by agro-cooperatives.", "funder_award_id": "14560177", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2500000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14560177/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Osamu", "family_name": "SAITO", "orcid": null, "role_start": null, "affiliation": {"name": "Chiba University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000040144894", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088506414", "display_name": "PHASE I STUDY OF PHOTODYNAMIC THERAPY FOR SURFACE MALIGNANCIES", "description": null, "funder_award_id": "1z01cm006379-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3774574", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "P", "family_name": "OKUNIEFF", "orcid": null, "role_start": null, "affiliation": {"name": "CANCER TREATMENT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088508042", "display_name": "SBIR Phase I: Drones for Industrial Indoor Robotic Applications", "description": "The broader impact / commercial potential of this project would be in the ability to deploy drones in industrial and commercial indoor environments as aerial robots. A key requirement to deploying drones in such indoor environments in the presence of people is to make them safe and non-threatening. In addition, for drones to function as robots, they need to be made fully autonomous and minimize the need for human operation or intervention. These attributes are not possible with conventional drone technology today. The ability to use drones as aerial robots can open up opportunities in large markets such as warehouse inventory scanning, construction, security, and factory automation. Such robots can enable functions such as scanning and reconstruction of the environment, or also ?pick and place? at high throughput within factories. The use of drones in industrial indoor environments for these applications can also result in broader societal benefits, including improved worker safety inside industrial indoor environments (by performing tasks that may otherwise require harnesses, forklifts or ladders); reduced environmental impacts (in construction sites by catching discrepancies early and minimizing rework and material wastage) and macroeconomic benefits (enabling automated factories of the future and bringing back US jobs). \r\n\r\nThis Small Business Innovation Research (SBIR) Phase I Project has the potential to advance the frontiers of knowledge in design and control systems for use in drones and other applications. This unique approach redefines the control systems for rotorcraft, and enables a drone with dramatically improved metrics ? as much as 10X -- that are traditionally used to characterize the performance of drones. In this Phase I project, Vimaan plans to complete the design and modeling of the system, develop the control mechanisms for the system, and integrate, test and demonstrate the application of the innovation to a drone that has the above attributes. During the project, Vimaan will need to overcome some critical technical challenges in the components and systems design, the control circuitry and controls algorithms and the power budgets, timings and optimizations of the sub-systems for the required performance. If successful, such an innovation would revolutionize decades old legacy technologies that have been hitherto deployed in rotorcraft, and make possible attributes that have been long sought after by the aerospace industry.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "1819709", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 225000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2018-06-15", "end_date": "2019-01-31", "start_year": 2018, "end_year": 2019, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1819709", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "SK", "family_name": "Ganapathi", "orcid": null, "role_start": null, "affiliation": {"name": "Vimaan Robotics, Inc.", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088509535", "display_name": "SCOOP: Environment for dependable distributed and reliable object-oriented computing, based on the principles of Design by Contact", "description": null, "funder_award_id": "100498", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 166688.0, "currency": "CHF", "funding_type": "research", "funder_scheme": "Project funding", "start_date": "2003-09-01", "end_date": "2005-08-31", "start_year": 2003, "end_year": 2005, "landing_page_url": "https://data.snf.ch/grants/grant/100498", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Meyer,", "family_name": "Bertrand", "orcid": null, "role_start": null, "affiliation": {"name": "ETH Zurich – ETHZ", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088510517", "display_name": "2007 PROTEINS GORDON RESEARCH CONFERENCE", "description": null, "funder_award_id": "1r13gm080752-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 5000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R13", "start_date": "2007-05-01", "end_date": "2008-04-30", "start_year": 2007, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/7268191", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHRISTOPHER P.", "family_name": "HILL", "orcid": null, "role_start": null, "affiliation": {"name": "GORDON RESEARCH CONFERENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088510996", "display_name": "STRUCTURAL STUDIES ON CYTOCHROME P450 &RELATED PROTEINS", "description": null, "funder_award_id": "5r01gm033688-15", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1987-03-01", "end_date": "2001-02-28", "start_year": 1987, "end_year": 2001, "landing_page_url": "https://reporter.nih.gov/project-details/2882998", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "THOMAS LEWIS", "family_name": "POULOS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA IRVINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40885110", "display_name": "食虫類モグラ科における地下適応の歴史は協調進化か?", "description": "食虫目モグラ科は、北アメリカから日本を含むユーラシア大陸に広く分布し、4つの亜科からなる17属が知られる。これらモグラ科内の系統関係を明らかにすることは、哺乳動物における完全地下生活型への進化や、小型哺乳類の大陸間移動の歴史を探るうえで重要である。これまでミトコンドリアDNA(チトクロームb遺伝子)を用いて解析を行ってきたが、本研究助成においては、核遺伝子であるRecombination Activating Gene 1 (RAG1)の塩基配列に基づいて解析を行つた。その結果、ミトコンドリア遺伝子では支持されなかったヒミズ亜科の単系統性が支持され、更にはこれまで十分な系統学的知見が得られていなかったホシバナモグラが、ユーラシア大陸の大型モグラ類と近縁である可能性が示された。しかしながら、北アメリカ大陸とユーラシア大陸のモグラ類の単系統性については支持が得られず、協調進化が起きた可能性を示唆した。すなわち、モグラ科の進化はユーラシア大陸起源であり、地上生活を行っていたトガリネズミ似のモグラ科の祖先が、ユーラシア大陸と北アメリカ大陸へ、それぞれ分布を広げて独立に地下生活へと適応していった可能性を明らかにした。また、一方で東南アジアにおいて新たなサンプルの解析をミトコンドリアDNA(チトクロームbおよび12SrRNA遺伝子)および核遺伝子(RAG1)によって行ったところ、東南アジアにスポット状に生息するミズラモグラ属が、残存種の集合体であることが明らかとなり、それぞれの地域個体群は起源が古く、いずれもが特徴的な遺伝的形質を維持したまま生息していることが明らかとなった。今後、東南アジア地域のモグラ類について、より解析を詳細に行うことによって、東アジア地域におけるモグラ科の多様性の高さの謎についても明らかとなるであろう。", "funder_award_id": "15770060", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1500000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15770060/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "明男", "family_name": "篠原", "orcid": null, "role_start": null, "affiliation": {"name": "University of Miyazaki(2004)宮崎医科大学(2003)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050336294", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408851213", "display_name": "Center for Studies in Demography and Ecology", "description": null, "funder_award_id": "5r24hd042828-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 588178.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R24", "start_date": "2002-07-05", "end_date": "2012-06-30", "start_year": 2002, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7499012", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN MARK", "family_name": "ELLIS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WASHINGTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088512193", "display_name": "HORMONE REPLACEMENT THERAPY AND LARGE BOWEL CANCER RISK", "description": null, "funder_award_id": "5r01ca076366-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-08-19", "end_date": "2002-05-31", "start_year": 1998, "end_year": 2002, "landing_page_url": "https://reporter.nih.gov/project-details/2896267", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "POLLY A", "family_name": "NEWCOMB", "orcid": null, "role_start": null, "affiliation": {"name": "FRED HUTCHINSON CANCER RESEARCH CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088512289", "display_name": "mobIQ", "description": "The mobIQ project will assess the commercial viability and technical practicalities of developing a unique technology to benchmark the quality and characteristics of mobile games, then enable individualised recommendations for mobile games players.\nOur focus is on using technology to significantly improve the process by which consumers find new mobile games with a high degree of probability that they will like them, continue to use them and thus be more likely to become paying customers of them. The goal is to be able to facilitate the trusted recommendation of good games to the players that would most likely enjoy them on whatever mobile platform and devices they use.\nIf this project is successful, our goal is to ultimately provide what could become the default consumer-facing discovery service of choice for digitally-delivered games on all mobile platforms.", "funder_award_id": "700343", "funder": {"id": "https://openalex.org/F4320335087", "display_name": "Innovate UK", "doi": "10.13039/501100006041"}, "amount": 21534.0, "currency": "GBP", "funding_type": "grd_proof_of_market", "funder_scheme": null, "start_date": "2014-02-01", "end_date": "2014-07-30", "start_year": 2014, "end_year": 2014, "landing_page_url": "https://gtr.ukri.org/projects?ref=700343", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088512780", "display_name": "Optimizing measures of subjective and objective decline in preclinical AD", "description": "PUBLIC HEALTH RELEVANCE: The proposed project will study subjective cognitive concerns (SCC) expressed by older individuals that may indicate evidence of very early Alzheimer's disease (AD). We will develop and utilize a novel instrument to probe specific SCC and relate them to objective neuropsychological measures, imaging markers of AD, and longitudinal clinical decline in order to better differentiate SCC associated with normal aging from those related to the earliest stages of AD.", "funder_award_id": "5k23ag044431-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 135912.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2014-04-01", "end_date": "2019-03-31", "start_year": 2014, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8823712", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "REBECCA E", "family_name": "AMARIGLIO", "orcid": null, "role_start": null, "affiliation": {"name": "BRIGHAM AND WOMEN'S HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088513330", "display_name": "Source de champs magnétique intégrée", "description": "No summary - Aucun sommaire", "funder_award_id": "370207-2008", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4500.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "University Undergraduate Student Research Awards", "start_date": "2008-04-01", "end_date": "2009-03-31", "start_year": 2008, "end_year": 2008, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=370207-2008", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Maxime", "family_name": "Rochette", "orcid": null, "role_start": null, "affiliation": {"name": "Université Laval", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088515844", "display_name": "NEW; RESEARCH IN HADRON PHYSICS; PI - WINSTON ROBERTS", "description": "NEW; RESEARCH IN HADRON PHYSICS; PI - WINSTON ROBERTS", "funder_award_id": "DESC0002615", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 910238.95, "currency": "USD", "funding_type": "grant", "funder_scheme": "OFFICE OF SCIENCE FINANCIAL ASSISTANCE PROGRAM", "start_date": "2009-09-01", "end_date": "2016-08-31", "start_year": 2009, "end_year": 2016, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_DESC0002615_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088516230", "display_name": "分子会合体の特異的光化学、光物理過程の解明とフォトニクス材料への応用", "description": "本研究は、フォトニクス材料の創成を目標として種々の分子会合体もしくは分子集合体の非線形光学応答に関して基礎と応用の両面から検討するものであり、研究初年度にあたる本年度は、自己集積化反応で得られる有機分子集合体の非線形光学応答について重点的に以下の様な検討を行った。1、モデル分子会合体の作成と会合形態の検討分子会合体として、チオールSelf-Assembly(SA)膜をモデル系として検討した。チオール分子の炭素鎖長や側鎖構造、あるいは自己集積化反応に用いる溶媒や反応条件等の違いが分子集合体としてのSA膜構造やSA膜形成反応に及ぼす点について検討するために、SA膜修飾基板の表面屈折率変化をモニターするホログラフィックな手法を新規に開発して、多結晶Au基板上のSA膜形成過程をその場観察することに成功した。2、金単結晶上におけるチオールSelf-Assembly(SA)膜形成上記手法により金多結晶上でSA膜形成に要する時間がチオール初期濃度に依存すること、また炭素鎖長が短い場合には電極ブロッキング特性が十分には得られないこと等が明らかになった。これを踏まえ、分子会合体の固定化をも考慮に入れて金単結晶上でSA膜形成反応を数種類の直鎖チオールを用いて行った。このとき、XRDや顕微FT-IR等の手法を用いて、火炎溶融法で作成した金単結晶微小球の微小ファセット面方位やSA膜内の分子配列などについて基礎的なキャラクタリゼーションを行い、所期の試料が得られたことを確認した。3、分子超薄膜で修飾されたAu(lll)面における光第二高調波発生の回転異方性測定SA膜修飾といった簡便な手法で界面原子配列の制御ができれば新規な界面制御、界面エンジニアリングの可能性が拓けるものとの期待から、SA膜修飾されたAu(lll)面における原子配列制御の可能性に関して基礎的な検討を行った。その際、下地Au単結晶原子配列の再構成構造を電気化学的に制御したり、また第二高調波発生の回転異方性からこれを明確に評価できること等を実際に測定したより明らかにできた。", "funder_award_id": "07246211", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2900000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research on Priority Areas", "start_date": "1995-04-01", "end_date": "1995-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07246211/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "凉", "family_name": "馬場", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Tokyo", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070198951", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088519988", "display_name": "Amazonian Center of Excellence in Malaria Research", "description": null, "funder_award_id": "2u19ai089681-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U19", "start_date": null, "end_date": "2024-03-31", "start_year": null, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/9263620", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RICARDO TOSTES", "family_name": "GAZZINELLI", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA, SAN DIEGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088520756", "display_name": "EBV Antigen and Cell Cycle Regulation", "description": " Project Narrative: The ubiquitous gammaherpesvirus Epstein Barr virus is associated with a range of human cancers. At least 6 latent genes have been shown to be critical for cell transformation in vitro. Some of these antigens associate directly with cell cycle regulatory proteins and are also linked to the specific regulation of cellular events which include regulation of transcription, chromatin remodeling, cell proliferation and cell cycle regulation. This proposal will explore the role of one of the essential nuclear antigens EBNA3C in determining a more comprehensive model for the related functions of EBNA3C in regulation of the major cellular oncoproteins E2F and c-Myc through post-translation modification and cell cycle regulation leading to transformation of human B cells.", "funder_award_id": "5r01ca137894-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 285308.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-01-01", "end_date": "2013-11-30", "start_year": 2009, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8197658", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ERLE S.", "family_name": "ROBERTSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088522313", "display_name": "The role of polymeric osteopontin on inflammation", "description": "In this study, I examined to reveal the role of polymerized osteopontin (catalyzed by protein-crosslink enzyme, transglutaminase 2) on inflammation. As a result, it was cleared that osteopontin and transglutaminase 2 were up-regulated by pro-inflammatry cytokine, TGF-β1 and the former was polymerized on cell membrane fraction by the latter. I was also successful in the generation on transgenic mice expressed polymerization-incompetent mutant osteopontin specific in lung.", "funder_award_id": "25840034", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3510000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": "2013-04-01", "end_date": "2015-03-31", "start_year": 2013, "end_year": 2015, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25840034/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "NORIHISA", "family_name": "NISHIMICHI", "orcid": null, "role_start": null, "affiliation": {"name": "Hiroshima University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000583486", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088522401", "display_name": "有機ピエゾクロミック発光材料創製に向けた双安定相のナノ構造設計", "description": "1,3,6,8-テトラフェニルピレン(TPPy)誘導体が示すピエゾクロミック発光について、ナノ集積構造が固体発光特性に与える効果とそのメカニズムの検討を通じて発光機構を検討した。TPPyのフェニル基にアルキルアミド基を導入した(Alkyl)AmTPPyは、アルキル基が直鎖ヘキシルの場合、固相で水素結合支配の規則構造をとり、青色発光を示すが、圧力負荷により規則構造が消失して発光は青緑に変化することが判明している。(Alkyl)AmTPPyについて側鎖アルキル基の分子構造の効果を検討したところ、アルキル鎖の炭素数をC6から増加させる、あるいは分岐アルキル構造に変えることで水素結合支配の規則構造形成能が低下し、同時にピエゾクロミック応答性も低下した。これは水素結合支配の規則構造形成に際して、アルキル鎖の分子体積も重要であることを示しており、双安定構造の設計に関するより精密な知見が得られた。また鎖長の短いプロピル基では、集積構造の変化が起きず、ピエゾクロミック応答性が失われ、アルキル基の構造が応答性制御にも重要であることが示された。一方、アミドをエステルに置き換えた(Alkyl)EsTPPyの固体発光は青緑色で、発光波長、量子収率、寿命などはいずれも圧力負荷後の(Alkyl)AmTPPyと同じであり、固相中で同一の環境下にあることが示唆された。(Alkyl)EsTPPyのX線結晶構造解析より、ピレン環同士のπ-πスタッキングは見られないがフェニル基水素とピレン環のC-H…π相互作用は確認され、水素結合がない(Alkyl)EsTPPyあるいは水素結合が乱れた(Alkyl)AmTPPyの(準)安定構造として、モノマー状態からの青緑色発光を示したことが判明した。水素結合がない(Alkyl)EsTPPyでは、圧力を負荷すると固体発光がさらに緑色まで変化し、加圧下でダイマー/エキサイマーが形成されて発光変化を示したものと推定された。以上の結果から、双安定相実現に向けたナノ構造設計をより精密化できただけでなく、水素結合がないエステル系での双安定構造を設計する道筋を示すことができ、設計指針の拡張にも成功した。", "funder_award_id": "19651040", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3300000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Exploratory Research", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19651040/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "孝二", "family_name": "荒木", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Tokyo", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000040134639", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088524129", "display_name": "The mechanism of hyperalgesia in duced by NMDA receptor activation.", "description": "Bolus injection of N-methyl-D-aspartate (NMDA) in to the intrathecal (IT) space of rat produces short lasting thermal hyperalgesia with pain behavior represented by vocalization, scratching and biting. These behavioral effects after IT injection of NMDA impedes the testing of the pain threshold of the paw. Moreover, the short lasting hyperalgesia kept us from examining the post treatment effect of any drugs after onset of the hyperalgesic state. To produce long lasting thermal hyperalgesia with little pain behavior, we applied continuous intrathecal infusion of NMDA in the rat. To evaluate the character of this model, effects of pre or post-treatment of MK801, a non-competitive NMDA antagonist, on the hyperalgesia, and gluatamate concentration in cerebro spinal fluid were tested. Method : Male Sprague-Dawley rats were used. IT catheters and loop catheters for microdyalysis were implanted according to the Yaksh method. Five to seven days after the surgery, NMDA (0,60,120,180 pmol/min) w…Moreere continuously infused through the IT catheter by the flow rate of 1μl/min for 30min, followed by 5 minutes interval assessment of paw thermal withdrawal latency (TWL) in response to light heat for 45 minutes. Experiments were performed according to a protocol approved by the Animal Care Committee of the University of the Ryukyus. Results : TWL in the 120 and 180 p mol/min groups were reduced 27.7% and 32.8% from the control value, respectively, 10 minutes after starting the IT infusion. Maximum reduction of TWL appeared after 25 minutes in both groups, and recovered 10 minutes after the infusion was terminated. MK-801 (non-competitive NMDA antagonist) injected prior to NMDA infusion completely abolish this hyperalgesia. However, MK-801 reduced the efficacy when given after established the hyperalgesia by NMDA infusion. Glutamate concentration in CSF was reduced by MK-801 when given prior to NMDA infusion.Conclusion : Continuous IT infusion of NMDA produced long lasting thermal hyperalgesia, which was dose dependent. The efficacies of MK-801 on hyperalgesia and glutamete concentration in CSF were reduced when given after established the hyperalgesia by NMDA activation.Less", "funder_award_id": "10671430", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3300000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10671430/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yasutoshi", "family_name": "HIGA", "orcid": null, "role_start": null, "affiliation": {"name": "University of the Ryukyus", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000228701", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088525146", "display_name": "EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS DURING EARLY MAMMALIAN DEVELOPMENT", "description": null, "funder_award_id": "1z01hd000918-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/4693817", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "K", "family_name": "OZATO", "orcid": null, "role_start": null, "affiliation": {"name": "CHILD HEALTH AND HUMAN DEVELOPMENT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088527534", "display_name": "CAREER: Stacks, moduli spaces, and log geometry", "description": "The PI studies both foundational questions and applications of stacks and logarithmic geometry. The project roughly breaks up into two parts. The first part concerns the study of moduli spaces and log geometry. Since log geometry and logarithmic structures are closely related to degenerations, log geometry plays a natural role in the study of compactifications of moduli spaces. The PI studies several problems related to log geometry and moduli spaces, and also studies a logarithmic Grothendieck-Riemann-Roch theorem, generalizing the classical theorem for schemes. The second part of the project concerns sheaves on algebraic stacks. A central theme in this part of the project is trace formulas and their generalizations to stacks. Central to all parts of the project is the close relationship between algebraic stacks and log geometry discovered in earlier work of the PI.\r\n\r\n\r\nGiven a system of polynomial equations defining an algebraic variety, there are two natural ways to study the system. One approach is to study the symmetries of the equations, and a second approach is to vary the coefficients of the equations (\"moduli\") and \"degenerate\" them to a simpler (though possibly singular) system. Stacks, introduced by Artin, Deligne, Grothendieck, and Mumford in the late 1960's, are the main tool used in algebraic geometry to study spaces with additional symmetries. In recent years, the theory of stacks has come to play an important role in almost every part of algebraic geometry, arithmetic geometry, and mathematical physics and a great number of exciting new \r\napplications of stacks have been found. For example, stacks play a \r\ncentral role in the study of Brauer groups and in the rich interaction between string theory and algebraic geometry. For the study of degenerations, a key tool is the theory of logarithmic geometry developed by Kato, Fontaine, and Illusie in the late 1980's. As mentioned above, in earlier work the PI related this theory to stacks, and the ongoing projects use this relationship to further our understanding of degenerations and the moduli of algebraic varieties.\r\n", "funder_award_id": "0748718", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 400006.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2008-06-01", "end_date": "2014-05-31", "start_year": 2008, "end_year": 2014, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748718", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Martin", "family_name": "Olsson", "orcid": null, "role_start": null, "affiliation": {"name": "University of California-Berkeley", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088528143", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "249440-2001", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Industrial Undergraduate Student Research Awards", "start_date": "2001-04-01", "end_date": "2002-03-31", "start_year": 2001, "end_year": 2001, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=249440-2001", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Hugues", "family_name": "Lafleur", "orcid": null, "role_start": null, "affiliation": {"name": "Forest Engineering Research Institute of Canada", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088530904", "display_name": "ANABOLIC ACTIONS OF INSULIN IN NEUROMUSCULAR DISEASE", "description": null, "funder_award_id": "1r01ar038894-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1989-03-01", "end_date": "1993-02-28", "start_year": 1989, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3158892", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RICHARD T", "family_name": "MOXLEY", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ROCHESTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088532663", "display_name": "BIOSYNTHESIS AND METABOLISM OF NUCLEOSIDES", "description": null, "funder_award_id": "2r01gm026166-14a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1978-12-01", "end_date": "1997-08-31", "start_year": 1978, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/3273662", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RONALD J", "family_name": "PARRY", "orcid": null, "role_start": null, "affiliation": {"name": "RICE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088533168", "display_name": "New Cell-Based Reporters for Genomics and Proteomics", "description": null, "funder_award_id": "1k22hg002671-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 263760.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K22", "start_date": "2003-01-24", "end_date": "2004-12-31", "start_year": 2003, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6571384", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ALICE Y", "family_name": "TING", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088533210", "display_name": "VALIDATION OF POSTINJECTION TRANSMISSION MEASUREMENTS FOR PET", "description": null, "funder_award_id": "1z01cl000801-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3774450", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "R E", "family_name": "CARSON", "orcid": null, "role_start": null, "affiliation": {"name": "CLINICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088533225", "display_name": "TAS::89 0321::TAS PERU ELECTRICAL DEPARTMENT WIND TURBINE GENERATION", "description": "TAS::89 0321::TAS PERU ELECTRICAL DEPARTMENT WIND TURBINE GENERATION", "funder_award_id": "DEEE0003280", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 1000000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "RENEWABLE ENERGY RESEARCH AND DEVELOPMENT", "start_date": "2010-08-01", "end_date": "2012-09-17", "start_year": 2010, "end_year": 2012, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_DEEE0003280_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088535768", "display_name": "Pre-College Teacher Development", "description": null, "funder_award_id": "8000746", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 50000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1980-02-01", "end_date": "1982-01-31", "start_year": 1980, "end_year": 1982, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8000746", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Nancy", "family_name": "Bauer", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088536230", "display_name": "有機LEDとフォトリフラクティブ材料の融合による有機レーザの開発", "description": "トリアジン(TRZ)骨格にドナー性置換基を導入した新規化合物は、高い励起3重項エネルギーレベルを有することから、有機LEDのホスト材料として有用である。また、ホスト材料としてはバイポーラキャリア輸送性や隣接有機層との間でエキサイプレックスを形成しないことが必要とされる。本研究では将来の有機レーザ素子への展開が可能な高性能な有機LED用ホスト材料の探索を目的とした。トリアリールアミン誘導体(TRZ-2,TRZ-4)、ピリジン誘導体(PYD-2)及びピリミジン誘導体(PYM-3)の Aryl-substituted Heterocyclic Compound (AHC)を新規に合成し、その光学特性、電荷輸送性及びリン光OLEDのホスト材料としての評価を行った。また、PEDOTをべ一スとするフォトリフラクティブ材料の特性評価を行なった。AHCを有機LEDの発光層に用いたデバイスにおいてAHCに由来するEL発光は観測されなかった。PYD-2を発光層に用いたデバイスでは、電子輸送層に用いたAlq_3からの発光のみが得られたことから、PYD-2中をホールのみが輸送されたことが確かめられた。同様にTRZ-2とPYM-3を用いたELスペクトルからは、α-NPDの発光成分が強く観測され、電子輸送性が強いバイポーラ性の電荷輸送機能を有することが分かった。さらに、TRZ4を用いたデバイスもバイポーラ性を示した。これらの結果から、ユニポーラ性材料のPYD-2はホール輸送層及び電子ブロック層として、バイポーラ性材料のTRZ-2、PYM-3、TRZ-4は、ホスト材料としての応用が期待できる。さらに、AHC層の厚みを20nm、40nm、90nmと変化させることによって、α-NPD成分の発光強度がAlq3に比べて著しく低下する結果が得られ、AHC層の厚みによってキャリア輸送性を制御できる可能性が示唆された。Coumarin6をドープしたPEDOT系材料でネットゲイン175cm-1、回折効率49%が得られ、実用可能なフォトリフラクティブ特性となった。今後は有機LEDとフォトリフラクティブ材料を組合わせた光デバイスへの展開に取組む。", "funder_award_id": "18655079", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3700000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Exploratory Research", "start_date": "2006-04-01", "end_date": "2006-03-31", "start_year": 2006, "end_year": 2006, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18655079/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "博之", "family_name": "雀部", "orcid": null, "role_start": null, "affiliation": {"name": "Chitose Institute of Science and Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020015126", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088538173", "display_name": "Rituximab in Graves’ Disease 2 (RiGD-2)", "description": "Background \nGraves’ disease (GD) is one of the more common disorders of the thyroid gland, affecting 700 young people in the UK each year. The thyroid gland controls brain, heart, bone and gut function. In GD, the immune system mistakenly stimulates the thyroid, causing it to produce too much thyroid hormone, leading to four main symptoms: weight loss, shakiness, heart racing and feeling hot or sweaty. This leads to a profound impact on physical health, quality of life, attention span and education or work performance. Patients can also develop thyroid eye disease, a disfiguring inflammation of the eye that can cause pain and distress, affects self-esteem and may even cause sight loss. Treating GD is more difficult in young people because standard antithyroid drug therapy (ATD) is more likely to result in side-effects and less likely to result in cure when treatment is stopped. Only 1 in 4 patients will require no further treatment after 2 years of ATD. Other treatment options if the GD recurs are thyroid surgery or radioactive iodine therapy. These are associated with additional risks and greater costs in the young, necessitate life-long thyroid hormone replacement and reduced quality of life. Rituximab (RTX) medication is used to treat many immune disorders. It works by targeting blood cells that make the antibodies responsible for attacking the thyroid in GD. A recent exploratory study in young patients with GD suggested that giving just one dose of RTX in addition to standard ATD is well tolerated and may increase the likelihood of remission. This exciting finding needs to be explored in the context of a bigger trial. \n\nAim \nTo determine whether a single dose of RTX, given in addition to 2 years of ATD, increases the remission rate in young people with GD. \n\nDesign and Method\nWe will recruit 124 young people (12-24 years old) with GD to a clinical trial in which they will be randomly allocated to one of two different treatments; either the usual 2-year course of ATD tablets, or a single dose of RTX as well as 2 years of ATD. RTX is given by a 3-hour drip and participants will not know whether they received RTX or a salt water (saline) infusion instead. They will have blood tests taken to check thyroid levels at 4 weeks, then every 8 weeks in the first year and 3- monthly thereafter. The number of visits is similar to standard NHS care. Travel costs will be reimbursed. To understand if the treatment has worked, we will compare the numbers in each of the 2 groups with normal thyroid function and who have had no further treatment 12 months after stopping ATD. If RTX improves the number of people with normal thyroid tests, it could be introduced as a new component of standard treatment. \n\nPatient and public involvement \nTo refine our study design, we liaised with a public panel from the Research Design Service North East and held 2 focus groups involving young people with GD. We were awarded a Public Involvement Fund grant to compensate contributors for their time and these individuals will also be invited to contribute to the ongoing study. The study group will include a representative from the British Thyroid Foundation (BTF), the largest thyroid patient organisation in the UK. \n\nDissemination \nStudy results will be discussed at key medical meetings including European Society for Paediatric Endocrinology and published in leading scientific journals. The BTF will share study updates on their website, via newsletters and social media.", "funder_award_id": "NIHR159329", "funder": {"id": "https://openalex.org/F4320319990", "display_name": "National Institute for Health and Care Research", "doi": "10.13039/501100000272"}, "amount": 3610849.32, "currency": "GBP", "funding_type": "research", "funder_scheme": "Efficacy and Mechanism Evaluation", "start_date": "2024-08-01", "end_date": "2030-07-31", "start_year": 2024, "end_year": 2030, "landing_page_url": "https://fundingawards.nihr.ac.uk/award/NIHR159329", "doi": null, "provenance": "nihr", "lead_investigator": {"given_name": "Claire", "family_name": "Wood", "orcid": "0000-0002-6084-5174", "role_start": null, "affiliation": {"name": "Newcastle University", "country": "Award does not have an ODA Downstream Partner", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408854162", "display_name": "DEFINITION OF THE PHYSIOLOGICAL PROPERTIES OF GIP", "description": null, "funder_award_id": "5r01dk053158-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1997-02-15", "end_date": "2001-01-31", "start_year": 1997, "end_year": 2001, "landing_page_url": "https://reporter.nih.gov/project-details/2872242", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MICHAEL", "family_name": "WOLFE", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408854305", "display_name": "Der Meister des TucherRetabels. Die Loslösung eines süddeutschen Malers vom Schönen Stil. Künstlerindividualität und Stilwahl im 15. Jahrhundert.", "description": "Forschungsgegenstand ist der Meister des Tucher-Retabels, der neben Hans Pleydenwurff als bedeutendster Nürnberger Maler vor Dürer gelten darf. Trotzdem kam seine Erforschung schon vor fast einem halben Jahrhundert zum Erliegen, ohne dass ein überzeugendes Bild von Person, Werkstatt und Werk erarbeitet, noch der Fragenkomplex um künstlerische Herkunft, Vorlagenwahl und stilistische Entwicklung systematisch-kritisch abgehandelt worden wäre. Mittels methodisch umfassend angelegter Untersuchungen kann am überlieferten Werk sowohl sein Ausgangspunkt im Schönen Stil als auch seine Loslösung von der Formensprache seiner Lehrer aufgezeigt werden. Der Tucher-Meister orientierte sich dabei am frühen niederländischen Realismus, griff aber auch Anregungen aus Italien auf. Diese bewusste Suche nach neuen Stilformen und Ausdrucksmitteln sowie die Ausbildung eines individuellen künstlerischen Idioms bezeugen einen Wandel im Kunst- und künstlerischen Selbstverständnis des Malers. Am Beispiel des Tucher-Meisters ließe sich so das künstlerische Wie als auch das mentalitätsgeschichtliche Warum des sich ab zirka 1420/30 auch in Süddeutschland vollziehenden Umbruchs in der bildenden Kunst aufzeigen. Archivalische Forschungen könnten eine Identifizierung dieses nach künstlerischer Individualität strebenden Anonymus ermöglichen.", "funder_award_id": "27603174", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 549708.3269000001, "currency": "EUR", "funding_type": "fellowship", "funder_scheme": "Forschungsstipendien", "start_date": "2006-01-01", "end_date": "2011-12-31", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/27603174", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088543226", "display_name": "MOLECULAR MECHANISM OF ASSEMBLY OF SINGLE MEMBRANE-BOUND ORGANELLS AND \"SORTING ENGINEERING\"", "description": "The methylotrophic yeast is widely used as a heterologous gene expression system in academic and applied fields. When cells are grown on methanol, a large volume of cells (up to 80%) was occupied by a single-membrane bound organelle, the peroxisome. The study was conducted to produce toxic oxidases within peroxisomes of the methylotrophic yeast, since many oxidases are useful for clinical diagnosis. To this end, the protein traffic was manipulated for efficient protein transport, and this strategy (or concept) was named \"sorting engineering\" (later biotraffic engineering). Since genetic diorders deficient in peroxisome assembly are known, the molecular mechanism for protein traffic to peroxisomes was in important in medical field and investigated using the methylotrophic yeast as a model organism. In this study, the information obtained from the basic research was applied to production of fungal fructosyl amino acid oxidase, which is useful for determination of glycated proteins. In diabetic patients, the level of glycated proteins is high. Using (i) an efficient targeting signal to peroxisomes and (ii) an alcohol-oxidase depleted strain, and (iii) optimizing codon usage and culture conditions, we could improve the enzyme productivity approximately 47-fold from the orginal transformant. The produced protein accumulated within membrane-bound peroxisomes up to nearly 20% of the toal soluble protein. This is the first successful example which was conducted based on the concept \"sorting engineering\" (\"biotraffic engineering\"), and a similar approach will be possible in any other eukaryotic cells for heterologous gene expression, especially for the production of toxic or membrane proteins.", "funder_award_id": "09460156", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 13800000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09460156/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yasuyoshi", "family_name": "SAKAI", "orcid": null, "role_start": null, "affiliation": {"name": "KYOTO UNIVERSITY", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000060202082", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088543268", "display_name": "Institute of Biology - RTI - 2017", "description": "The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and establishement of a NB3 lab are proposed. (AU)", "funder_award_id": "17/11181-7", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "infrastructure", "funder_scheme": "Auxílio à Pesquisa - Reserva Técnica para Infraestrutura Institucional de Pesquisa", "start_date": "2017-07-01", "end_date": "2019-06-30", "start_year": 2017, "end_year": 2019, "landing_page_url": "https://bv.fapesp.br/en/auxilios/17-11181-7/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Alexandre", "family_name": "Leite Rodrigues de Oliveira", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088544020", "display_name": "3/3 COMpAAAS Tripartite: ART-CC, KP, and VA", "description": "Public Health Relevance: The set of 3 applications extends the generalizability of research on health consequences of alcohol in people living with HIV in the Veterans Aging Cohort study to 12 healthcare systems in North America and Europe. The set increases the number of women, younger individuals, men who have sex with men and uninfected comparators. This application addresses interactions between alcohol, tobacco and drug use, antiretrovirals, and co medications that result in mortality, hospitalization, or increased physiologic frailty.", "funder_award_id": "5u01aa026224-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 585586.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2017-09-20", "end_date": "2022-08-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9768292", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "AMY CAROLINE", "family_name": "JUSTICE", "orcid": null, "role_start": null, "affiliation": {"name": "YALE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088544195", "display_name": "Mitochondrial DNA Mutations and the Aging Process", "description": null, "funder_award_id": "1r01ag021905-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 381273.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-05-01", "end_date": "2008-04-30", "start_year": 2003, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/6594804", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "TOMAS A.", "family_name": "PROLLA", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WISCONSIN MADISON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088545306", "display_name": "Impact of Sleep in the Restoring Insulin Secretion (RISE) Study", "description": "PUBLIC HEALTH RELEVANCE: Short sleep duration and obstructive sleep apnea (a treatable disorder characterized by repetitive upper airway closures leading to sleep fragmentation, chronic sleep loss as well as cyclical drops of oxygen levels) are highly prevalent in the community. Both laboratory and epidemiologic studies have identified insufficient sleep, sleep fragmentation, poor sleep quality and sleep apnea, as putative novel risk factors for type 2 diabetes. The overall objectives of this proposal for an Ancillary Study to the parent RISE (Restoring Insulin Secretion) Study are: 1) To determine whether quantitative measures of sleep quantity and quality are associated with baseline measures of beta-cell function (insulin secretion) and insulin sensitivity, and 2) To determine whether the presence and severity of sleep disturbances predict beta-cell responses to pharmacological interventions designed to preserve and/or restore insulin secretion in prediabetes or early stage type 2 diabetes.", "funder_award_id": "5r01hl119161-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 388473.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2013-08-01", "end_date": "2017-04-30", "start_year": 2013, "end_year": 2017, "landing_page_url": "https://reporter.nih.gov/project-details/8708962", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BABAK", "family_name": "MOKHLESI", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CHICAGO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088547172", "display_name": "培地浸透圧に応答した大腸菌外膜蛋白質遺伝子の発現制御におけるEnvZ蛋白質の機能", "description": "Principal Investigator：饗場 浩文, Project Period (FY)：1989 – 1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (Research Fellowship), Research Field：発酵・醸造", "funder_award_id": "01790451", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (Research Fellowship)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01790451/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088550258", "display_name": "Design, Monitoring and Operation of Adaptive Networked Embedded Systems", "description": "Large scale societal challenges require large scale monitoring and control solutions. Technological developments will make it possible to design and build these large systems. A major obstacle in realizing these systems is the lack of a versatile methodology to design and implement adaptive monitoring and control systems taking into account intrinsic properties of system of systems (decentralization, dynamic requirements, continuous evolution and changing components).\nThe goal of DEMANES is to provide component-based methods, framework and tools for development of runtime adaptive systems, making them capable of reacting to changes in themselves, in their environment (battery state, availability and throughput of the network connection, availability of external services, etc.) and in user needs (requirements).\n• to model the architecture and the operation of adaptive systems\n• to support the design process of such systems by providing simulation and evaluation environments and test-beds\n• to support the implementation of such system by providing services for self organization, reconfiguration and self optimization as parts of the execution environment\n• to verify and test adaptive systems\n• to monitor the internal and external operational conditions and manage adaptation at run time.\nIn order to go beyond the state of the art DEMANES combines recent advances from systems and control engineering.\nThe concept, methodology and tools developed in DEMANES will be validated and demonstrated in three use cases: smart urban transport, smart airport and smart home. To reach the ambitious goals of DEMANES in the spirit of the ARTEMIS programme a large consortium is necessary to cover the range of disciplines necessary. The partners in the DEMANES consortium are complementary in terms of technical competencies and organizational, business and market experience.\n..\nAPPROVED BY ARTEMIS-JU on 17-03-2015", "funder_award_id": "295372", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 3285004.39, "currency": "EUR", "funding_type": "grant", "funder_scheme": "FP7 - JTI-CP-ARTEMIS", "start_date": "2012-05-01", "end_date": "2015-06-30", "start_year": 2012, "end_year": 2015, "landing_page_url": "https://cordis.europa.eu/project/id/295372", "doi": "", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "ITA-SUOMEN YLIOPISTO", "country": "FI", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088551834", "display_name": "Lipid Peroxidation", "description": null, "funder_award_id": "7915328", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 114832.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1980-05-01", "end_date": "1983-10-31", "start_year": 1980, "end_year": 1983, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7915328", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Steven", "family_name": "Aust", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088553255", "display_name": "Quantum Operator Approaches to Multidimensional Reaction Dynamics", "description": "Steven Schwartz is supported by a grant from the Theoretical and Computational Chemistry Program to perform theoretical research in the application of evolution operators to condensed phase systems consisting of a few quantum degrees of freedom in contact with a solvent bath. This model is useful for theoretical treatments of chemical reactions in the presence of solvent. Schwartz has developed a propagator expansion resummation technique which shows significant promise in terms of improved accuracy and range of applicability for treating many dimensional chemical reactions. He plans to apply this theory to the elucidation of the mechanism of rate processes in multiple pulse ligand photolysis experiments on hemoglobin. A great deal of progress has been made in the theoretical treatment of gas phase chemical reactions of systems consisting of relatively few atoms. Using state-of-the-art theoretical methods, it is now possible to explain a great deal of the experimental detail for such systems. However, the large majority of reactions which are of interest to chemists occur in condensed phase systems in the presence of solvent. The theoretical models for treating such complex systems are in a much earlier stage of development. Schwartz is developing new theoretical approaches for dealing with solvated chemical systems undergoing chemical reactions where quantum effects may be important.", "funder_award_id": "9312443", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 249000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1994-01-01", "end_date": "1997-06-30", "start_year": 1994, "end_year": 1997, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312443", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Steven", "family_name": "Schwartz", "orcid": null, "role_start": null, "affiliation": {"name": "Albert Einstein College of Medicine", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088556911", "display_name": "TWO-DIMENSIONAL NMR STUDIES--AT-CONTAINING NUCLEIC ACIDS", "description": null, "funder_award_id": "1r01gm039247-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1988-02-01", "end_date": "1993-01-31", "start_year": 1988, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3296044", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "THOMAS L", "family_name": "JAMES", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA SAN FRANCISCO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408855694", "display_name": "INNOVATIVE MULTI-SPECTRAL MAGNETRONS", "description": "INNOVATIVE MULTI-SPECTRAL MAGNETRONS", "funder_award_id": "N000141310566", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 600033.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "BASIC AND APPLIED SCIENTIFIC RESEARCH", "start_date": "2015-03-09", "end_date": "2016-04-30", "start_year": 2015, "end_year": 2016, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_N000141310566_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088560114", "display_name": "NEW AWARD TO MORGAN STATE UNIVERSITY. PROJECT TITLED: CERAMIC-BASED ULTRA-HIGH TEMPERATURE THERMOCOUPLES IN HARSH ENVIRONMENTS", "description": "NEW AWARD TO MORGAN STATE UNIVERSITY. PROJECT TITLED: CERAMIC-BASED ULTRA-HIGH TEMPERATURE THERMOCOUPLES IN HARSH ENVIRONMENTS", "funder_award_id": "DEFE0031906", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 500000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "UNIVERSITY COAL RESEARCH", "start_date": "2020-08-01", "end_date": "2023-07-31", "start_year": 2020, "end_year": 2023, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_DEFE0031906_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088560718", "display_name": "The basic research on high-efficiency non-contact drive by the shape design of diamagnetic graphite plates", "description": "In 2006, we reported that novel contact-free linear motion technique by using PG plate above linear permanent magnet (PM) track. It is that PG plate, which levitates at room temperature, can move in a unique magnetic field gradient induced by interaction between linear PM track and an approaching PM piece.Recent years, we had been doing a quantitative observation of diamagnetic repulsion force that depends on the edge shape of the PG plate sample by quasi-static measurement technique. An interesting result was obtained from the present experimental data. It is the diamagnetic repulsion force appeared in one direction when the two PM pieces are located respectively on both ends of the asymmetric shape PG plate sample with a slant treated edge in the thickness direction. It is seems that this characteristics is one of effective technical elements to constitute a high efficiency contact-free magnetic suspension motion model using PG Plate sample.", "funder_award_id": "23560307", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4810000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2011-04-28", "end_date": "2015-03-31", "start_year": 2011, "end_year": 2015, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23560307/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Haruhiko", "family_name": "SUZUKI", "orcid": null, "role_start": null, "affiliation": {"name": "Fukushima National College of Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030201578", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088564875", "display_name": "Generation of a functionally robust stem cell based therapy for type 1 diabetes", "description": "A cure for type 1 diabetes may lie in the replacement of insulin-producing cells by transplantation. Hundreds of patients worldwide (including ~400 in Canada) have received transplants of islets - clusters of insulin-producing cells in the pancreas - enabling better blood glucose control without the need for insulin administration. Yet because there are not enough organ donors, new sources of insulin-producing cells are needed for the millions living with this disease. We can now generate insulin-producing cells from stem cells but these cells do not secrete insulin properly nor do they survive transplantation without immunosuppression. In response, our team aims to use our combined expertise in single cell technologies, genome editing, immunology, and stem cell and islet biology to produce a new and improved cell source for cell replacement therapy in diabetes, that can be tested in clinical trial in a few years. Such an advance could not only transform the lives of thousands of Canadians living with diabetes but also greatly reduce the tremendous economic and health burden that diabetes places on Canada today.", "funder_award_id": "173663_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 1494952.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Team Grant: CIHR-JDRF - Accelerating Stem Cell-Based Therapies for Type 1 Diabetes", "start_date": "2020-12-01", "end_date": "2025-11-30", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Francis", "family_name": "Lynn", "orcid": null, "role_start": "2020-12-01", "affiliation": {"name": "University of British Columbia", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088565710", "display_name": "基質小胞構成成分の精製とその組織内発現", "description": "Principal Investigator：馬場 友巳, Project Period (FY)：1991, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：Functional basic dentistry", "funder_award_id": "03771313", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1991-04-01", "end_date": "1991-03-31", "start_year": 1991, "end_year": 1991, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03771313/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088565939", "display_name": "GROUND SUBSTANCE AND LUNG TISSUE PROPERTIES", "description": null, "funder_award_id": "5r01hl030919-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1983-09-01", "end_date": "1986-11-30", "start_year": 1983, "end_year": 1986, "landing_page_url": "https://reporter.nih.gov/project-details/3341922", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CARROLL J", "family_name": "MARTIN", "orcid": null, "role_start": null, "affiliation": {"name": "BENAROYA RESEARCH INST AT VIRGINIA MASON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088568362", "display_name": "ALTERNATIVE MODELS FOR DELIVERING RURAL CRISIS SERVICES", "description": null, "funder_award_id": "1r18mh047814-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R18", "start_date": "1990-09-30", "end_date": "1995-08-31", "start_year": 1990, "end_year": 1995, "landing_page_url": "https://reporter.nih.gov/project-details/3442869", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "NANCY Z", "family_name": "WILSON", "orcid": null, "role_start": null, "affiliation": {"name": "COLORADO STATE DEPT OF INSTITUTIONS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408857006", "display_name": "Investigating the metabolic and cognitive mechanisms of LEAP2 in anorexia nervosa", "description": "Anorexia nervosa (AN) is a complex psychiatric disorder of unknown etiology. Treatments aim to restore normal weight, but the relapse remains high (> 40%) with persistence of altered feeding behavior. Alteration of brain reward processes (i.e. reduced reward value of food and increased reward value of thinness) and deficit in cognitive flexibility, are hallmarks of AN. Poor cognitive flexibility is associated with the severity and outcome of the disorder. A better understanding of the core mechanisms of abnormal cognitive control and reward processes in AN will help to better prevent and treat this severe psychiatric disorder. AN has been re-conceptualized as a metabo-psychiatric disorder. We thus hypothesized that the reward and cognitive alterations that occur during chronic undernutrition in AN, would be mediated by peripheral metabolic sensors, dysregulated in AN, through their targeted action on homeostatic feeding circuits which in turn will lead to increased cognitive control and impaired reward processes. We will test our hypothesis in a translational and innovative study, using a) mouse models in which we will mimic the metabolic signature of AN in order to trigger AN core symptoms and b) a longitudinal study in patients with AN in which we will correlate neurocognitive, brain activation, metabolic and genetic biomarkers with the balance of these metabolic sensors. Homeostatic and cognitive neuronal circuits altered by these metabolic sensors and their contribution to vulnerability to AN will be explored in mice using in vivo imaging with fiber photometry and two-photon calcium imaging. Subsequently, genetically defined modulation of neuronal activity in the mouse using pharmacogenetics will be used to correct the AN phenotype. We aim to gain a better understanding of the pathways linking homeostatic circuits with those involved in cognitive and reward processes that are abnormal in AN and to provide useful knowledge for considering new targets for therapeutic intervention.", "funder_award_id": "ANR-25-CE37-4997", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 511885.0, "currency": "EUR", "funding_type": "research", "funder_scheme": "AAPG2025", "start_date": "2025-12-01", "end_date": null, "start_year": 2025, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-25-CE37-4997", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Virginie", "family_name": "TOLLE", "orcid": "https://orcid.org/0000-0003-4456-0002", "role_start": null, "affiliation": {"name": "INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE", "country": "France", "ids": [{"id": "200816530M", "type": "rnsr", "asserted_by": "anr"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088570128", "display_name": "ASTHMA TRAINING FOR INNER CITY PRIMARY CARE PROVIDERS", "description": null, "funder_award_id": "5k07hl003062-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K07", "start_date": "1993-09-30", "end_date": "1998-08-31", "start_year": 1993, "end_year": 1998, "landing_page_url": "https://reporter.nih.gov/project-details/2211028", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GEORGE T", "family_name": "O'CONNOR", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088570407", "display_name": "Mechanism of Protein Accumulation in Renal Hypertrophy", "description": null, "funder_award_id": "5r01dk073476-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 326175.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-05-01", "end_date": "2013-04-30", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8068186", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HAROLD A", "family_name": "FRANCH", "orcid": null, "role_start": null, "affiliation": {"name": "EMORY UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088573671", "display_name": "PGSA/ESA", "description": "No summary - Aucun sommaire", "funder_award_id": "186225-1996", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 5932.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Postgraduate Scholarships", "start_date": "1998-04-01", "end_date": "1999-03-31", "start_year": 1998, "end_year": 1998, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=186225-1996", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Lianne", "family_name": "Fisher", "orcid": null, "role_start": null, "affiliation": {"name": "Queen's University", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088576572", "display_name": "Transcription factor function in chromatin", "description": null, "funder_award_id": "5r01gm056244-12", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 367650.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1997-08-01", "end_date": "2011-02-28", "start_year": 1997, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7576170", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANTHONY N", "family_name": "IMBALZANO", "orcid": null, "role_start": null, "affiliation": {"name": "UNIV OF MASSACHUSETTS MED SCH WORCESTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088578295", "display_name": "Development of New Functional Polymer Materials containing Various Phosphine Blocks in the Main Chain", "description": "The synthesis of organophosphine-organic/inorganic-polymer hybrid polymers with various structures has been established using P-C cross-coupling polymerization. Water-soluble polymer catalysts and novel materials with self-healing properties were developed by the application of the synthesized hybrid polymers, especially on complexation with transition metals. The P=S-polymer-Pd sub-nanoparticle catalysts have been shown to exhibit unique selectivity. In addition, many valuable findings on organophosphine chemistry were obtained, including the synthesis of chiral phosphines and cyclic phosphine compounds.", "funder_award_id": "18H02022", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 14040000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (B)", "start_date": "2018-04-01", "end_date": "2023-03-31", "start_year": 2018, "end_year": 2023, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18H02022/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Minoru", "family_name": "Hayashi", "orcid": null, "role_start": null, "affiliation": {"name": "Ehime University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020272403", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088578854", "display_name": "VIDEO ALCOHOL EDUCATION FOR NATIVE AMERICAN FAMILIES", "description": null, "funder_award_id": "n44aa010008-001", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N44", "start_date": "1991-09-30", "end_date": "1993-09-29", "start_year": 1991, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/2293480", "doi": null, "provenance": "nih_exporter", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088580002", "display_name": "Mechanisms involved in uremic toxin mediated down regulation of ApoA-I expression", "description": null, "funder_award_id": "5f32dk082130-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 62980.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2009-07-01", "end_date": "2013-06-30", "start_year": 2009, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8122373", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HAMID", "family_name": "MORADI", "orcid": null, "role_start": null, "affiliation": {"name": "SOUTHERN CALIFORNIA INST FOR RES/EDUC", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088583815", "display_name": "VASCULAR CELL DIFFERENTIATION IN TISSUE ENGINEERED STRUC", "description": null, "funder_award_id": "5r01hl060490-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 330000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-07-10", "end_date": "2003-06-30", "start_year": 1998, "end_year": 2003, "landing_page_url": "https://reporter.nih.gov/project-details/6537404", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOYCE E.", "family_name": "BISCHOFF", "orcid": null, "role_start": null, "affiliation": {"name": "CHILDREN'S HOSPITAL BOSTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088584208", "display_name": "TRAINING PROGRAM/RHEUMATIC DISEASES", "description": null, "funder_award_id": "2t32ar007442-06a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "training", "funder_scheme": "T32", "start_date": "1982-09-20", "end_date": "1994-08-31", "start_year": 1982, "end_year": 1994, "landing_page_url": "https://reporter.nih.gov/project-details/3532040", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERT B", "family_name": "ZURIER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408858421", "display_name": "GOAL Project: Developing Technology Support for Acquisition of Self Direction Skill", "description": "For the 21st century learner, self-direction is a crucial skill. This proposal outlines an interdisciplinary data driven approach to support acquisition of Self-Direction Skill. It envisions to design and develop Goal Oriented Active Learner (GOAL) system to synchronize-visualize-analyze multisource data regarding student’s learning and physical activities. Synchronous logging of learner’s learning and physical activities shall generate a data poll that potentially opens up further research opportunities at the intersection of LA (Learning Analytics) and QS (Quantified-Self) research.", "funder_award_id": "19K20942", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2990000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Research Activity Start-up", "start_date": "2018-08-24", "end_date": "2020-03-31", "start_year": 2018, "end_year": 2020, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K20942/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Rwito", "family_name": "Majumdar", "orcid": null, "role_start": null, "affiliation": {"name": "Kyoto University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030823348", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088584694", "display_name": "DIABETES AND WELLNESS OUTCOME RESEARCH FOR THE REPUBLIC OF THE MARSHALL ISLANDS", "description": "DIABETES AND WELLNESS OUTCOME RESEARCH FOR THE REPUBLIC OF THE MARSHALL ISLANDS", "funder_award_id": "W81XHW0510547", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 842000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "MILITARY MEDICAL RESEARCH AND DEVELOPMENT", "start_date": "2005-08-31", "end_date": "2008-07-05", "start_year": 2005, "end_year": 2008, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_W81XHW0510547_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088584914", "display_name": "Investigating the shikimate pathway in Plasmodium falciparum", "description": "Project Narrative Malaria is a life-threatening disease that is caused by the Plasmodium parasite. I plan to investigate aromatic amino acid biosynthesis in Plasmodium falciparum, the deadliest species of the parasite, to evaluate the potential of the pathway as a drug target to treat malaria.", "funder_award_id": "5f32gm093510-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 51326.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2010-03-01", "end_date": "2012-08-31", "start_year": 2010, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/8045421", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "EMILY R", "family_name": "DERBYSHIRE", "orcid": null, "role_start": null, "affiliation": {"name": "HARVARD MEDICAL SCHOOL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088586887", "display_name": "Assembly of E. coli ribosomes in vitro and in cells", "description": null, "funder_award_id": "5r37gm053757-14", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 478529.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R37", "start_date": "1996-02-01", "end_date": "2013-01-31", "start_year": 1996, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7561061", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES R", "family_name": "WILLIAMSON", "orcid": null, "role_start": null, "affiliation": {"name": "SCRIPPS RESEARCH INSTITUTE, THE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088589411", "display_name": "Changes in expression levels of ERCC1, DPD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer", "description": "Our previous study showed that administering oxaliplatin as first-line chemotherapy increased expression levels of ERCC1and DPD in liver CRC metastases. Second, whether the anti-VEGF monoclonal antibody bevacizumab alters tumoral VEGFA levels is unknown. We conducted this study to validate our previous findings on ERCC1 and DPD, and clarifiy the response of tumoral VEGFA expression to bavacizumab administration. ERCC1 mRNA expression was significantly higher in the chemotherapy group than in the non-chemotherapy group, and were significantly correlated. VEGFA expression level was higher in patients receiving bevacizumab than in those who did not. This study confirmed that first-line oxaliplatin-based chemotherapy increases ERCC1 and DPD expression levels, potentially enhancing chemosensitivity to subsequent therapy. We also found that bevacizumab induces VEGFA expression in tumor cells, suggesting a biologic rationale for extending bevacizumab treatment beyond first progression.", "funder_award_id": "25670588", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3640000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Challenging Exploratory Research", "start_date": "2013-04-01", "end_date": "2015-03-31", "start_year": 2013, "end_year": 2015, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670588/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "hideo", "family_name": "BABA", "orcid": null, "role_start": null, "affiliation": {"name": "Kumamoto University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020240905", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088589702", "display_name": "CD38-targeted immunoPET of myeloma: Phase 2 trial of clinical applications", "description": "Project Narrative Current methods of measuring disease burden in myeloma are suboptimal, which limits clinical care of patients with myeloma. Our recent phase I, first-in-human trial of CD38-targeted immunoPET with 89Zr-DFO- daratumumab successfully demonstrated sensitive imaging of myeloma beyond the abilities of current imaging modalities; this phase II trial would identify promising clinical applications of 89Zr-DFO-daratumumab immunoPET in patients with myeloma, including histologic proof of imaging findings. Successful imaging would be transformative for the detection of myeloma, monitoring response to therapy, and future design of novel radioimmunotherapies for patients with myeloma.", "funder_award_id": "1r01ca248398-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 135622.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2020-07-01", "end_date": "2020-09-01", "start_year": 2020, "end_year": 2020, "landing_page_url": "https://reporter.nih.gov/project-details/9942003", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CARL OLA", "family_name": "LANDGREN", "orcid": null, "role_start": null, "affiliation": {"name": "SLOAN-KETTERING INST CAN RESEARCH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088589827", "display_name": "Prenatal exposure to phthalates and neurodevelopment in children", "description": "PROJECT NARRATIVE Phthalates are synthetic chemicals used in personal care products and in flexible plastic products. Human exposure occurs via diet, inhalation and dermal absorption. Due to their widespread use, phthalate metabolites are almost universally present in human urine at varying levels in the U.S. population. Phthalates are endocrine disrupting chemicals capable of crossing the placenta and the prenatal period is a particularly sensitive window for effects on the developing brain. This study will be an important contribution to the literature necessary for informing the public about the potential hazard associated with prenatal exposure to phthalates on cognitive and behavioral development.", "funder_award_id": "1r03es027139-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 78500.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R03", "start_date": "2016-09-01", "end_date": "2018-08-31", "start_year": 2016, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/9168535", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SHARON K.", "family_name": "SAGIV", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA BERKELEY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088589888", "display_name": "CELL ADHESION MOLECULE L1 AND MENTAL RETARDATION", "description": null, "funder_award_id": "1r01ns034252-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-12-09", "end_date": "1997-11-30", "start_year": 1994, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/2273423", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "VANCE P", "family_name": "LEMMON", "orcid": null, "role_start": null, "affiliation": {"name": "CASE WESTERN RESERVE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088590461", "display_name": "Collaborative Research: Improving Student Success in General, Organic, and Biological Chemistry with Community-Refined Courseware", "description": "This project aims to serve the national interest by enhancing undergraduate student success in General, Organic, and Biological (GOB) Chemistry, which is an important gateway course for health-related careers such as nursing and dietetics. Improving student success in GOB Chemistry would help address predicted shortages of healthcare workers in the future and broaden access to these STEM careers. The project team will develop GOB course materials for both online and in-class active learning. The project will also grow a Community of Practice, including GOB instructors and allied health instructors, that will use the educational materials and contribute to their development. This will help insure that the materials and activities are coupled to allied health contexts and provide knowledge for student success in health professions. The online portion of the courseware replaces current textbooks and online homework systems with an integrated system that combines instruction with practice opportunities and checkpoint quizzes. Extensive hints and feedback will help students learn in an efficient manner. In-class instruction will be supported through a collection of active-learning materials set in allied health contexts. Data regarding student use of the materials developed will be used to drive revisions to the content that improve student learning and success. Improved student success in GOB chemistry courses may differentially support students from groups underrepresented in STEM since research shows these students are more likely to persist in STEM when they earn grades of C or better.\r\n\r\nThe collaborative project team from Carnegie Mellon University and Mount San Antonio College will develop, implement, and evaluate online courseware and evidence-based materials and practices for General, Organic, and Biochemistry courses. The materials will include an emphasis on applications to careers in healthcare to maximize their relevance for students. The project team will also cultivate an instructor Community of Practice (CoP) to develop in-class course materials and iteratively refine the online courseware. The project team will assess the extent to which the online courseware engages and supports students' success in GOB courses, including the retention of students from groups underrepresented in STEM. Key questions include: What factors are most predictive of student learning and course success in GOB Chemistry and how malleable are these factors? To what extent do modifications to courseware based on learning data lead to demonstrable improvements in student learning and course success? How does situating GOB Chemistry in allied health contexts alter student learning and course success? To address the research questions, the project team will leverage the detailed data on student interactions gathered by the online courseware system. This includes \"learning curves,\" constructed for each student and chemistry knowledge component, that describe students' progress with respect to each knowledge component. Such data, collected throughout the learning process, provide more detail than pre- and post-tests that assess learning at only two time points. In addition, data gathered throughout the entire semester enable analyses that examine student learning across a broad range of topics. These rich data will be combined with survey data describing student characteristics and classroom practices to address research questions related to the factors that most influence student learning and course success and the impacts of situating learning in allied health contexts. These data will also provide an evidence base that the CoP and courseware developers will use to drive iterative improvements to learning resources. Further, summaries of these data are shared with faculty members to inform their instruction, including in-class time and their one-on-one interactions with students. The courseware developed will be made available free for independent learners and about $25 per student when used (with additional supports) in academic courses. The NSF IUSE: EDU Program supports research and development projects to improve the effectiveness of STEM education for all students. Through the Engaged Student Learning track, the program supports the creation, exploration, and implementation of promising practices and tools.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2337209", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 464845.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2024-08-15", "end_date": "2027-07-31", "start_year": 2024, "end_year": 2027, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2337209", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "David", "family_name": "Yaron", "orcid": null, "role_start": null, "affiliation": {"name": "Carnegie-Mellon University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088592874", "display_name": "Methamphetamine Effects on Dendrodendritic Dopamine Transmission in the VTA", "description": null, "funder_award_id": "7k01da021699-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 80210.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K01", "start_date": "2007-05-01", "end_date": "2012-04-30", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7755112", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MICHAEL J", "family_name": "BECKSTEAD", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TEXAS HLTH SCIENCE CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088594618", "display_name": "Mitochondrial Affect on Olfactory Neuron Output", "description": null, "funder_award_id": "5f32dc006542-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 51548.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2003-09-01", "end_date": "2006-08-31", "start_year": 2003, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6936558", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "LINAS A", "family_name": "BUNTINAS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO DENVER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088595885", "display_name": "Improvement of cognitive performances by stimulus noise and adaptive mental set", "description": "When two targets are embedded in a rapid serial visual presentation stream of distractors, perception of the second target is impaired when the inter-target lag is relatively short (less than 500 ms). Stimuli concurrently presented with the stream can affect this phenomenon, which is called attentional blink (AB). Previous studies have yielded conflicting results concerning the direction of the effect of added distractors on the AB: some studies report an increased AB, while others report a decreased AB. The present study explored the boundary conditions of the exaggeration/reduction effects of distractors on the AB and investigated underlying mechanisms by manipulating the spatial configuration, timing, and type of distractors. The results indicate that the magnitude of the AB deficit increased, regardless of the type of distractors, when spatial uncertainty of the target locations was involved. The reduction of the AB occurred at optimal presentation of distractors and disappeared when the second target was presented at a suprathreshold level. These results suggest that stochastic resonance or the centre-surround attentional mechanism may contribute to the reduction effect of distractors on the AB deficit.", "funder_award_id": "20530676", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4290000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20530676/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Jun-Ichiro", "family_name": "KAWAHARA", "orcid": null, "role_start": null, "affiliation": {"name": "National Institute of Advanced Industrial Science and Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030322241", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088598708", "display_name": "Corpus der Stempelsiegel-Amulette aus Palästina/Israel. Von den Anfängen bis zur Perserzeit. Katalog, Band I: von Tell Abu Farag bis 'Atlit", "description": null, "funder_award_id": "48040", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 78800.0, "currency": "CHF", "funding_type": "grant", "funder_scheme": "Publication grants", "start_date": "1996-07-05", "end_date": "1996-08-04", "start_year": 1996, "end_year": 1996, "landing_page_url": "https://data.snf.ch/grants/grant/48040", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Keel,", "family_name": "Othmar", "orcid": null, "role_start": null, "affiliation": {"name": "University of Fribourg – FR", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088599432", "display_name": "Bilder von Europa im Mittelalter", "description": null, "funder_award_id": "120231", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 204000.0, "currency": "CHF", "funding_type": "research", "funder_scheme": "Project funding (special)", "start_date": "2009-03-01", "end_date": "2011-02-28", "start_year": 2009, "end_year": 2011, "landing_page_url": "https://data.snf.ch/grants/grant/120231", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Oschema,", "family_name": "Klaus", "orcid": null, "role_start": null, "affiliation": {"name": "University of Berne – BE", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088601789", "display_name": "Forward engineering to understand gene regulatory network topologies", "description": "PUBLIC HEALTH RELEVANCE: Gene regulatory networks (GRNs) are, both topologically and functionally, composed of small network motifs. These motifs are prevalent in many critical biological processes, including cell cycle regulation, circadian rhythm, and metabolism, development, and cell differentiation. Furthermore, network motifs are also embedded in GRNs related to human diseases such as cancer and diabetes. Results from the proposed forward engineering studies will allow us to probe principles of cellular decision-making through network motifs. A better understanding of functions of these motifs will greatly extend our capability to identify new therapeutic targets, reprogram cell fate for regenerative medicine, and to engineer synthetic biological systems. ", "funder_award_id": "1r01gm106081-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 324449.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2014-09-26", "end_date": "2019-06-30", "start_year": 2014, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/8762282", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "XIAO", "family_name": "WANG", "orcid": null, "role_start": null, "affiliation": {"name": "ARIZONA STATE UNIVERSITY-TEMPE CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088602724", "display_name": "Continuous Monitoring of Turning in Patients with Parkinson's Disease", "description": " This project aims to develop and test the feasibility of an instrumented measure of turning during daily activities that is sensitive to the turning difficultis of patients with Parkinson's disease. We will use special, wearable sensors produced by our start-up company, APDM, to have patients record and upload their own daily mobility performance. More precise measures of turning mobility will improve intervention for balance disorders and fall prevention in the elderly and in patients with neurological disease. ", "funder_award_id": "5r41ns076088-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 349224.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R41", "start_date": "2012-07-01", "end_date": "2015-03-31", "start_year": 2012, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8495435", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "FAY BAHLING", "family_name": "HORAK", "orcid": null, "role_start": null, "affiliation": {"name": "APDM, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088603858", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "143889-1993", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 7127.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "1967 Science and Engineering Scholarships", "start_date": "1995-04-01", "end_date": "1996-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=143889-1993", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Rina", "family_name": "Carlini", "orcid": null, "role_start": null, "affiliation": {"name": "University of Waterloo", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088605619", "display_name": "New functional aspects of eicosanoids", "description": "Mass spectrometry is a highly sensitive, selective and rapid technique for characterizing multiple species of lipids, simultaneously, without the need for prior isolation and derivatization of compounds of interest. Coupled to ultra-pressure liquid chromatography (UHPLC-MS) is a powerful tool for identification, characterization and quantification of lipid mediators in complex matrices, allowing identification of lipid regiosomers. Lipidomics is the identification and quantification of lipids in biological systems, being the same, as a tool to evaluate the profile of certain lipid classes in immune and inflammatory responses. In our projects, we will focus our analysis to the class of eicosanoids, membrane phospholipids and neutral lipids. The formation of the Centre of Excellence for Quantification and Identification of Lipids (CEQIL), justifies the request of UHPLC-MS/MS system for this purpose. So, by being the first Lipid Analysis Center, using this technology in Brazil, this equipment (mass spectrometer) will have multiuser character, allowing the insertion of the quantification and identification of lipids in various interest projects such as biotechnology, clinical and basic research. So even being targeted primarily to analysis of a class of biomolecules (lipids), the use of the equipment will be constant and will have high demand, allowing the generation of new knowledge, scientific articles of impact and technological advances. (AU)", "funder_award_id": "15/00658-1", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "infrastructure", "funder_scheme": "Auxílio à Pesquisa - Programa Equipamentos Multiusuários", "start_date": "2016-03-01", "end_date": "2018-02-28", "start_year": 2016, "end_year": 2018, "landing_page_url": "https://bv.fapesp.br/en/auxilios/15-00658-1/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Lúcia", "family_name": "Helena Faccioli", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088607244", "display_name": "PHILIPS CM10 TRANSMISSION ELECTRON MICROSCOPE", "description": null, "funder_award_id": "1s10rr003276-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "S10", "start_date": "1987-02-17", "end_date": "1988-02-16", "start_year": 1987, "end_year": 1988, "landing_page_url": "https://reporter.nih.gov/project-details/3519603", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PASQUALE P", "family_name": "GRAZIADEI", "orcid": null, "role_start": null, "affiliation": {"name": "FLORIDA STATE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408861073", "display_name": "PHOSPHOLIPID TRANSFER DURING INTESTINAL ABSORPTION", "description": null, "funder_award_id": "1r01dk040641-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1988-09-01", "end_date": "1991-08-31", "start_year": 1988, "end_year": 1991, "landing_page_url": "https://reporter.nih.gov/project-details/3241058", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN WYLIE", "family_name": "NICHOLS", "orcid": null, "role_start": null, "affiliation": {"name": "EMORY UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088613029", "display_name": "Implantação da infra-estrutura dos novos laboratórios do NUPEGEL no Campus da USP - Piracicaba", "description": "Dotar os novos laboratórios (área de 32,50 m²) do NUPEGEL em Piracicaba (Campus da USP) da infraestrutura necessária para o desenvolvimento de pesquisas voltadas para o estudo da evolução, transformação e degradação dos solos tropicais (naturais e antrópicas) através da utilização de métodos geoquímicos e geofísicos. (AU)", "funder_award_id": "98/07969-5", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "infrastructure", "funder_scheme": "Auxílio à Pesquisa - Programa Infraestrutura - Gerais", "start_date": "1998-12-01", "end_date": "2000-01-31", "start_year": 1998, "end_year": 2000, "landing_page_url": "https://bv.fapesp.br/en/auxilios/98-07969-5/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Adolpho", "family_name": "José Melfi", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALQ)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088613746", "display_name": "AMPK as an Interventional Target to Suppress the Development of Osteoarthritis", "description": "PUBLIC HEALTH RELEVANCE: Osteoarthritis (OA) is the most common form of arthritis, and an enormous and expensive public health problem. There are yet no medical therapies (disease modifying OA drugs (DMOADS)) to prevent or effectively slow the primary disease process. Age and joint injury are the two major risk factors for OA development. Veterans are at high risk to develop OA as many are older and/or had traumatic joint injury when they were in and after service. Thus, the unmet medical need for new and effective therapeutics for OA is particularly urgent for the special needs of the health care of Veterans. Completion of these studies will potentially provide a novel approach to protect cartilage degradation by targeted activation of AMPK, thereby to prevent and therapeutically slow OA development and progression.", "funder_award_id": "5i01bx002234-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "I01", "start_date": "2014-10-01", "end_date": "2018-09-30", "start_year": 2014, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/9487129", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RU", "family_name": "BRYAN", "orcid": null, "role_start": null, "affiliation": {"name": "VA SAN DIEGO HEALTHCARE SYSTEM", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088614045", "display_name": "Dopamine Function After Prenatal Ethanol Exposure", "description": null, "funder_award_id": "5r01aa012435-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 320963.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1999-04-01", "end_date": "2011-03-31", "start_year": 1999, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7406845", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROH-YU", "family_name": "SHEN", "orcid": null, "role_start": null, "affiliation": {"name": "STATE UNIVERSITY OF NEW YORK AT BUFFALO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088614543", "display_name": "Function of post-translational modifications of protein backbones in signalling and molecular ageing", "description": "Proteins during their lifetime accumulate spontaneous modifications of their polypeptide backbone. Such alterations are often implicated in detrimental processes, directly destroying protein function or potentially triggering auto-immune responses and protein aggregation in amyloid diseases. Nevertheless, some protein backbone modifications have been proposed to confer a gain of function and act as molecular timers in cellular senescence signalling pathways. However, the systematic analysis of backbone modifications has been hampered by the lack of suitable tools and access to defined model systems. I propose to address this issue through the development and application of several chemistry-driven paradigms. First, I will prepare semi-synthetic proteins with site-specifically installed backbone modifications to enable direct measurement of the functional consequence of these ageing-related alterations. In particular, I will focus on the role of iso-aspartate residues in biomedically important systems including p53 and chromatin. Moreover, I aim to identify new ageing sensor and senescence factors through the development of a novel chemo-enzymatic proteomics strategy based on designer proteases, engineered to act on damaged proteins. Collectively, this interdisciplinary approach aims to establish protein backbone modifications as an important new field of biological regulation.", "funder_award_id": "360G-Wellcome-202250_Z_16_Z", "funder": {"id": "https://openalex.org/F4320311904", "display_name": "Wellcome Trust", "doi": "10.13039/100010269"}, "amount": 1063486.0, "currency": "GBP", "funding_type": "fellowship", "funder_scheme": "Sir Henry Dale Fellowship", "start_date": "2016-08-01", "end_date": "2023-07-31", "start_year": 2016, "end_year": 2023, "landing_page_url": "https://wellcome.org/grant-funding/people-and-projects/grants-awarded?q=360G-Wellcome-202250_Z_16_Z", "doi": null, "provenance": "wellcome_trust", "lead_investigator": {"given_name": "Dr Manuel M", "family_name": "Mueller", "orcid": null, "role_start": null, "affiliation": {"name": "King's College London", "country": "United Kingdom", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088614893", "display_name": "Vigo County Public Library - to expand public access to computers and the Internet", "description": "to expand public access to computers and the Internet", "funder_award_id": "OPP9513", "funder": {"id": "https://openalex.org/F4320306137", "display_name": "Bill and Melinda Gates Foundation", "doi": "10.13039/100000865"}, "amount": 113308.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Global Development", "start_date": "2001-06-01", "end_date": "2001-10-31", "start_year": 2001, "end_year": 2001, "landing_page_url": "https://www.gatesfoundation.org/about/committed-grants?q=OPP9513", "doi": null, "provenance": "gates_foundation", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "Vigo County Public Library", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088616524", "display_name": "Parp Function in Prostate Cancer", "description": "PROJECT NARRATIVE Prostate cancer remains the second leading cause of deaths due to cancer in North American men. Defining the communication pathways within prostate cancer cells, which is to say, how proteins talk to each other, is critical for discovering and improving drugs that kill prostate cancer cells. We have identified a new communication pathway that operates in prostate cancer cells, and we propose to determine how it works, and whether manipulating the pathway will inhibit prostate cancer cells.", "funder_award_id": "5r01ca214872-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 354284.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2017-03-01", "end_date": "2023-02-28", "start_year": 2017, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10091413", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BRYCE", "family_name": "PASCHAL", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF VIRGINIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088617616", "display_name": "CEREBRAL ISCHEMIA--DAMAGE DURING ANESTHESIA", "description": null, "funder_award_id": "2r01gm039771-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1988-04-01", "end_date": "2000-03-31", "start_year": 1988, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2022207", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DAVID", "family_name": "WARNER", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088618413", "display_name": "Can mannosylated dendrimers inhibit HIV-1 infection of DC-SIGN expressing cells", "description": null, "funder_award_id": "1r21ai071877-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 183650.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2007-09-15", "end_date": "2009-08-31", "start_year": 2007, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7230592", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CARA-LYNNE", "family_name": "SCHENGRUND", "orcid": null, "role_start": null, "affiliation": {"name": "PENNSYLVANIA STATE UNIV HERSHEY MED CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088619289", "display_name": "Assembly and Function of the Yeast Spore Wall", "description": "8. PROJECT NARRATIVE The fungal cell wall is the interface between the cell and its environment. In pathogenic fungi, proper function of the cell wall is important for survival in the host, and drugs targeting cell wall assembly are effective antifungal agents. The spores of baker's yeast Saccharomyces cerevisiae are not pathogenic but are surrounded by a complex coat, the spore wall, which includes many of the same components found in the walls of pathogenic fungi. We are using spore wall formation as a model system to unravel the biochemistry and genetics of fungal wall assembly. This application focuses on understanding how a conserved set of proteins localized on lipid droplets promote the formation of a specific structural feature in the cell wall.", "funder_award_id": "2r01gm072540-17", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 369641.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2005-09-12", "end_date": "2026-08-31", "start_year": 2005, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10515471", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "AARON M", "family_name": "NEIMAN", "orcid": null, "role_start": null, "affiliation": {"name": "STATE UNIVERSITY NEW YORK STONY BROOK", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088624314", "display_name": "KEIJI OHTSUKI / UNIVERSITY OF COLORADO - BOULDER DYNAMICAL EVOLUTION OF RING-SATELLITE SYSTEMS WE PROPOSE TO CONTINUE OUR STUDY OF THE DYNAMICAL EVOL", "description": "KEIJI OHTSUKI / UNIVERSITY OF COLORADO - BOULDER DYNAMICAL EVOLUTION OF RING-SATELLITE SYSTEMS WE PROPOSE TO CONTINUE OUR STUDY OF THE DYNAMICAL EVOL", "funder_award_id": "NNX08AL20G", "funder": {"id": "https://openalex.org/F4320306101", "display_name": "National Aeronautics and Space Administration", "doi": "10.13039/100000104"}, "amount": 329086.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "SCIENCE", "start_date": "2014-02-10", "end_date": "2014-02-10", "start_year": 2014, "end_year": 2014, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_NNX08AL20G_080/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408862678", "display_name": "Identifying genes predisposing to dilated cardiomyopathy in dogs and humans", "description": "Both dogs and humans are often affected by cardiovascular disease. The two species also share the majority of their genes and live in a similar environment. Dog breeding has generated a genome structure that makes disease mapping very efficient. This proposal is aimed to identify genetic risk factors for dilated cardiomyopathy (DCM) involved in both canine and human DCM and will therefore lead to improved canine and human health. DCM is a heart muscle disease resulting in a dilation of cardiac cavities and a thinning of the cardiac walls and is among the most common forms of cardiomyopathy in both large-sized dog breeds and humans. We have performed genome-wide association studies in two high-risk dog breeds, the Newfoundland and the great Dane, and identified several associated genomic regions, which contain excellent candidate genes. The aim of this study is to re-sequence the candidate loci to identify the disease-causing mutations and functionally validate these genetic risk factors. We will then apply these findings to human DCM patients. This will be done by re-sequencing orthologous genes in human DCM patient cohorts to identify candidate mutations in humans. We expect to identify and functionally validate disease-causing mutations underlying DCM in both dogs and humans. Ultimately this will lead to development of personalized medicine and improved canine and human health.", "funder_award_id": "2011-00825_Formas", "funder": {"id": "https://openalex.org/F4320321033", "display_name": "Svenska Forskningsrådet Formas", "doi": "10.13039/501100001862"}, "amount": 2460000.0, "currency": "SEK", "funding_type": "grant", "funder_scheme": "Unclassified", "start_date": "2011-01-01", "end_date": "2011-12-31", "start_year": 2011, "end_year": 2011, "landing_page_url": "https://www.vr.se/swecris#/project/2011-00825_Formas", "doi": null, "provenance": "formas", "lead_investigator": {"given_name": "Göran Ka", "family_name": "Andersson", "orcid": "0000-0001-5131-3144", "role_start": null, "affiliation": {"name": "Swedish University of Agricultural Sciences", "country": "Sweden", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088628725", "display_name": "PGSA", "description": "No summary - Aucun sommaire", "funder_award_id": "265766-2003", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 17300.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Postgraduate Scholarships", "start_date": "2004-04-01", "end_date": "2005-03-31", "start_year": 2004, "end_year": 2004, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=265766-2003", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "StanleyTszKit", "family_name": "Ng", "orcid": null, "role_start": null, "affiliation": {"name": "University of Waterloo", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088629060", "display_name": "Instrumentation for Introductory Laboratories in the Physical Sciences Department", "description": "Amarillo College will update and improve introductory physics, astronomy, and physical science courses. A major aim is to provide a sufficient quantity of high-quality instruments for students to use, so that students may experience interesting and instructive experiments. The project involves using nuclear counting, optics, mechanical, and astronomical equipment, some of which will be used in several laboratories. Experiments will be done in medical physics, college and engineering physics, physical science, and astronomy. The college will match the award with an equal amount of funds.", "funder_award_id": "8951985", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 12685.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1989-07-01", "end_date": "1991-12-31", "start_year": 1989, "end_year": 1991, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8951985", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Arthur", "family_name": "Schneider", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088635082", "display_name": "シリケンイモリの生殖についての研究", "description": "これまでの研究で本州・四国・九州に分布するアカハライモリでは、生殖器官が繁殖可能になる秋から配偶行動を始めているが、貯精したまま春まで繁殖はしないことをわかった。しかし、これはCynops属の最北に分布するアカハライモリの繁殖期についての結論であり、その他のCynops属の生殖及び生態について調べることなしには、この属の繁殖戦略は理解できない。アカハライモリ以外のCynops属は、ほとんどの種が中国に生息しているが、アカハライモリと中国のイモリの分布のちょうど真ん中の南西諸島にシリケンイモリCynops ens icaudaが分布している。本研究では、シリケンイモリの生殖について調べることによって、Cynops属の繁殖戦略を解明することを目指した。研究対象としたシリケンイモリは準絶滅危惧(NT)に指定されている種で、近年、圃場整備や水路工事などの土地開発による繁殖場所の減少や観賞用の成熟個体の乱獲等で個体数が激減している。そのことを考慮して、生息数が多く、人為的な捕獲圧が少ないと考えられる地域を選んで、(1)野外での1年間を通しての生態調査と(2)生殖器官の観察(卵巣、輸卵管及び精巣、輸精管の精子数の季節変化)を行った。生態調査では、繁殖期前の12月から5月にかけて、雨の日に自動車による礫死体を多く確認した。そして、道路に敷設されたコンクリートU字側溝が繁殖期で移動する個体にとって集団死する「死のトラップ」になっていることも分かった。調査地はイタチの移入でヘビ類が捕食され絶滅に近い状態に至った歴史をもっている。幸いにもイモリは捕食対象でないということで生き延びてきたが、これまで生き延びてきたイモリもU字側溝への転落という別の理由によって激減することが推測される。生殖器官の年変化では、精子は産卵期前の11月でも確認できるが、卵巣重量/体重の増減で比較することによって、繁殖の最盛期は12月から2月であることがわかった。実際に1月、2月の個体で輸卵管中に産卵直前の卵が確認できた。シリケンイモリでは、アカハライモリのように冬期に繁殖行動を中断することなく、生殖器官の成熟に伴って、繁殖行動に入り1月から産卵を開始し、アカハライモリより早い時期に産卵を終えていることがわかった。", "funder_award_id": "24924001", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 600000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Scientists", "start_date": "2012-04-01", "end_date": "2012-03-31", "start_year": 2012, "end_year": 2012, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24924001/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088635235", "display_name": "Between the market and the hierarchy: an analysis of cases of contractual hold-up in agribusiness.", "description": null, "funder_award_id": "97/00242-0", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Exterior", "start_date": "1997-04-26", "end_date": "1997-04-29", "start_year": 1997, "end_year": 1997, "landing_page_url": "https://bv.fapesp.br/en/auxilios/97-00242-0/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Decio", "family_name": "Zylbersztajn", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Faculdade de Economia, Administração e Contabilidade (FEA)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088640644", "display_name": "SYNTHESIS AND FUNCTION OF POLYMERS IN ORAL BACTERIA", "description": null, "funder_award_id": "5r01de006748-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1984-01-01", "end_date": "1987-08-31", "start_year": 1984, "end_year": 1987, "landing_page_url": "https://reporter.nih.gov/project-details/3220257", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "TEH-HSING", "family_name": "CHIU", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088640904", "display_name": "Portable High Intensity Focused Ultrasonic System", "description": null, "funder_award_id": "1r43gm066422-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 99294.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R43", "start_date": "2002-08-10", "end_date": "2004-02-09", "start_year": 2002, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6549309", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BRUCE J", "family_name": "MORTIMER", "orcid": null, "role_start": null, "affiliation": {"name": "ENGINEERING ACOUSTICS, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088641622", "display_name": "Highly stable Ag clusters developed by a combustion reaction", "description": "Agクラスターは特異な活性や選択性を持つため、新規高性能触媒として期待されている。しかしAgは他の貴金属と比較して熱的安定性に乏しく容易に凝集するため、工業利用が困難である。本研究では、工業化実績のある火炎噴霧熱分解法を用いて、「燃焼場により還元された酸化物担体とAg間の相互作用を利用した、Agクラスター安定化技術」を創出する。", "funder_award_id": "22K14534", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Early-Career Scientists", "start_date": "2022-04-01", "end_date": "2024-03-31", "start_year": 2022, "end_year": 2024, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K14534/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Kakeru", "family_name": "Fujiwara", "orcid": null, "role_start": null, "affiliation": {"name": "Kanazawa University(2023)Yamagata University(2022)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070816628", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088642221", "display_name": "Fairness in data-driven medical technologies: Solidifying regulatory oversight based on a multidimensional conception of fairness", "description": "Artificial intelligence (AI) and genomic technologies are transforming healthcare, offering powerful tools for diagnosis and treatment. However, these innovations often fail to fairly serve diverse populations due to lack of inclusivity. This project aims to develop a comprehensive fairness framework for medical AI and genomics, considering ethical, legal, and social factors. By engaging stakeholders—including patients, clinicians, and policymakers—it will propose regulatory solutions to ensure equitable healthcare technology. The findings will help create guidelines for fair and inclusive AI, ensuring that all individuals, regardless of background, benefit from medical advancements in a responsible and just manner.", "funder_award_id": "VI.Vidi.241R.006", "funder": {"id": "https://openalex.org/F4320321800", "display_name": "Nederlandse Organisatie voor Wetenschappelijk Onderzoek", "doi": "10.13039/501100003246"}, "amount": null, "currency": "EUR", "funding_type": "fellowship", "funder_scheme": "NWO-Talentprogramma Vidi SGW 2024 - SGW/SSH Recht en Bestuur", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://www.nwo.nl/projecten/VI-Vidi-241R-006", "doi": null, "provenance": "nwopen", "lead_investigator": {"given_name": "Mahsa", "family_name": "Shabani", "orcid": null, "role_start": null, "affiliation": {"name": "Universiteit van Amsterdam", "country": "Netherlands", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408864274", "display_name": "Développement d'un procédé de production de Me-THF biosourcé", "description": "Le furfural (dérivé des sucres en C5), une molécule structurellement similaire au 5-hydroxymethylfurfural (derivé des sucres en C6), est un dérivé furanique généré (i) par le procédé FIRSST de CRB Innovations lors du fractionnement des biomasses ainsi que par (ii) la conversion directe des C5 présents dans des hydrolysats et vinasses. Le furfural est une molécule biosourcée, suscitant un grand intérêt du fait de la possibilité de sa transformation en différents produits recherchés dans lindustrie. Ainsi, le furfural peut être converti en méthylfurane (2MF), cyclopentane, alcool furfurylique (FA), en tetrahydrofurfuryl alcool (THF-OH) et en méthyltétrahydrofurane (2Me-THF). Le méthyltétrahydrofurane a été identifié comme un solvant vert et renouvelable possédant plusieurs applications en chimie organique. \nComme cest un solvant aprotique, il possède une faible miscibilité dans leau, une forte basicité Lewis et une grande stabilité dans lacide, faisant du 2Me-THF une meilleure option que le tétrahydrofurane (THF) ou le dichlorométhane dans une large gamme de réactions organiques telles que les réactions Grignard et les substitutions nucléophiles. \nPlus important encore que son usage comme solvant, le 2Me-THF est un excellent additif renouvelable pour les carburants et ce grâce à ses très bonnes propriétés de combustion comparativement à léthanol, une plus grande capacité calorifique, une faible chaleur de vaporisation et sa faible solubilité dans leau.\nLe projet vise à valider la faisabilité de procédés économiquement viables de production du méthyltétrahydrofurane (2Me-THF) en utilisant les produits du procédé FIRSST obtenus à partir du panic érigé comme matière première, vu sa haute teneur en hémicellulose.", "funder_award_id": "ccard-2022-00614", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 100000.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "CCI Applied Research and Development Grants", "start_date": "2023-04-01", "end_date": "2024-03-31", "start_year": 2023, "end_year": 2023, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=CCARD-2022-00614", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Yacine", "family_name": "Boumghar", "orcid": null, "role_start": null, "affiliation": {"name": "Collège de Maisonneuve", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088642894", "display_name": "Toward Improved Candid Classroom Instructional Television: Guidelines For Program Evaluation and Production", "description": null, "funder_award_id": "7919041", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 132640.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1979-10-01", "end_date": "1982-03-31", "start_year": 1979, "end_year": 1982, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7919041", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Charles", "family_name": "Hutchinson", "orcid": null, "role_start": null, "affiliation": {"name": "University of Massachusetts Amherst", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088643382", "display_name": "DNA REPAIR DEFECTS AFFECTING HEMATOPOIETIC STEM CELLS", "description": null, "funder_award_id": "5r01ca063193-09", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 267750.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-05-01", "end_date": "2006-02-28", "start_year": 1994, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6700236", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STANTON L", "family_name": "GERSON", "orcid": null, "role_start": null, "affiliation": {"name": "CASE WESTERN RESERVE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088643493", "display_name": "SUSHIL ATREYA/UNIVERSITY OF MICHIGAN TO THE DEPTHS OF VENUS: A COMPREHENSIVE EXPLORATION OF ATMOSPHERIC DYNAMICS AND CHEMISTRY ON OUR SISTER WORLD", "description": "SUSHIL ATREYA/UNIVERSITY OF MICHIGAN TO THE DEPTHS OF VENUS: A COMPREHENSIVE EXPLORATION OF ATMOSPHERIC DYNAMICS AND CHEMISTRY ON OUR SISTER WORLD", "funder_award_id": "NNX09AJ63G", "funder": {"id": "https://openalex.org/F4320306101", "display_name": "National Aeronautics and Space Administration", "doi": "10.13039/100000104"}, "amount": 430194.74, "currency": "USD", "funding_type": "grant", "funder_scheme": "AEROSPACE EDUCATION SERVICES PROGRAM", "start_date": "2017-02-02", "end_date": "2017-02-02", "start_year": 2017, "end_year": 2017, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_NNX09AJ63G_080/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088644442", "display_name": "Finding Sleeping Beauty: T Cell Biosensors for Dormant Cancer Detection", "description": "PROJECT NARRATIVE Some types of cancers, as exemplified by estrogen receptor positive breast cancer, can recur as metastatic disease many years or even decades following a dormancy period where the patient displays no clinical symptoms. This proposal seeks to engineer T cells as ultrasensitive biosensors to detect dormant cancer and when they reawaken.", "funder_award_id": "5dp1ca280832-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1107400.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "DP1", "start_date": "2022-09-20", "end_date": "2027-08-31", "start_year": 2022, "end_year": 2027, "landing_page_url": "https://reporter.nih.gov/project-details/10707371", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GABRIEL A", "family_name": "KWONG", "orcid": null, "role_start": null, "affiliation": {"name": "GEORGIA INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088648993", "display_name": "Clinical Research Network in Non-Alcoholic Steatohepatitis", "description": null, "funder_award_id": "5u01dk061730-06", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 334604.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2002-05-01", "end_date": "2009-04-30", "start_year": 2002, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7236668", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES A", "family_name": "TONASCIA", "orcid": null, "role_start": null, "affiliation": {"name": "JOHNS HOPKINS UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088650277", "display_name": "Suppression of electromogration under high magnetic field", "description": "Electromigration is a phenomenon of atomic transport under an electric field (direct current). Lorentz force can be produced by applying a magnetic field in the direction perpendicular to an electric field, which is expected to suppress the atomic movement due to electromigration. The purpose of the present work is to investigate whether hillocks and avoids are formed in electromigration in aluminum thin films under the magnetic field. The present result shows that neither hillocks nor voids were observed in the electromigration for 1.8×104 s under 10 tesla.", "funder_award_id": "16K14376", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3640000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Challenging Exploratory Research", "start_date": "2016-04-01", "end_date": "2019-03-31", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K14376/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Hideo", "family_name": "Nakajima", "orcid": null, "role_start": null, "affiliation": {"name": "Wakasa wan Energy Research Center", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030134042", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088650943", "display_name": "Data Analysis for the September 19, 1985 Michoacan, Mexico Earthquake", "description": "The work proposed will attempt to take full advantage of information generated by the recent Michoacan, Mexico earthquake of September 19, 1985, and information potentially available from another large earthquake anticipated in the near future in the adjacent Guerrero seismic gap and/or Omtepec seismic gap to the southeast.", "funder_award_id": "8618312", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 95000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1987-06-15", "end_date": "1988-11-30", "start_year": 1987, "end_year": 1988, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8618312", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "James", "family_name": "Brune", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088651177", "display_name": "Risk Prediction Using 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Patients With Type B Acute Aortic Syndrome", "description": "The current study examined the clinical significance of 18F-FDG-PET in patients with IMH in comparison to those with classic AD. During the median follow-up of 664 days, 37.3% of the patients had adverse aorta-related events. The higher total 18F-FDG uptake, defined as a sum of 18F-SUV uptake over the regions that had inflammatory pathology in the entire affected thoracic aorta, was associated with an increased risk of aorta-related event in patients with IMH even after multivariable adjustment, but not in those with AD. 18F-FDG-PET/CT might be useful for risk stratification in patients with IMH.", "funder_award_id": "16K09487", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2016-04-01", "end_date": "2019-03-31", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K09487/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Shuichiro", "family_name": "Kaji", "orcid": null, "role_start": null, "affiliation": {"name": "Kobe City Medical Center General Hospital(First Clinical Division, Second Clinical Division, Third(2018)Foundation for Biomedical Research and Innovation(2016-2017)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000080330554", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408865151", "display_name": "A Role for PML in Genome Stability and DNA Damage Response", "description": null, "funder_award_id": "5r01ca055577-15", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 264061.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1992-09-01", "end_date": "2012-02-29", "start_year": 1992, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7373528", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KUN-SANG", "family_name": "CHANG", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TX MD ANDERSON CAN CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088652865", "display_name": "Alcohol Epidemiological Data System (AEDS)", "description": null, "funder_award_id": "267200800023c-2-0-1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1087634.0, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "2008-09-30", "end_date": "2013-09-29", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7941293", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HSIAO-YE", "family_name": "YI", "orcid": null, "role_start": null, "affiliation": {"name": "CSR, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088652882", "display_name": "Problems in Topology and Algebra", "description": null, "funder_award_id": "6216630", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1962-01-01", "end_date": "1963-01-01", "start_year": 1962, "end_year": 1963, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=6216630", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088654505", "display_name": "計算状態パーソナル・スクラップブック", "description": "コンピュータの計算状態が直接見えないことと刻々と変化することが、これまでのプログラミングを難しくしてきました。ここでは、プログラムの作成・検査・文書化・理解を容易にする目的で、汎用プログラミング言語の実行状況のスナップショットを収集・保存し再利用することを可能にした、計算状態パーソナル・スクラップブックの研究を行います。", "funder_award_id": "JPMJPR00P6", "funder": {"id": "https://openalex.org/F4320334789", "display_name": "Japan Science and Technology Agency", "doi": "10.13039/501100002241"}, "amount": null, "currency": null, "funding_type": "grant", "funder_scheme": "戦略的な研究開発の推進/戦略的創造研究推進事業/さきがけ 機能と構成", "start_date": "2000-04-01", "end_date": "2004-03-31", "start_year": 2000, "end_year": 2004, "landing_page_url": "https://projectdb.jst.go.jp/grant/JST-PROJECT-7700000662/", "doi": "http://dx.doi.org/10.52926/jpmjpr00p6", "provenance": "crossref_work", "lead_investigator": {"given_name": "Potter", "family_name": "Richard Lee", "orcid": null, "role_start": null, "affiliation": {"name": "科学技術振興事業団, 個人研究推進事業", "country": null, "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088658541", "display_name": "Pii-dependent resistance, as a model to elucidate molecular mechanism of effector-triggered immunity and pathogen recognition.", "description": "Currently, it has been known that plant NLR type immune receptors have integrated domains (IDs) derived from other host proteins. Some reports showed that IDs bind to pathogen effectors and enable NLRs to recognize pathogen effectors, directly. Therefore, IDs are regarded as important information to understand host-pathogen interactions.In this study, we found the ID of rice NLR, Pii, and showed that the Pii-ID did not contribute to direct binding to cognate fungal effector, AVR-Pii. On the other hand, Pii-ID had crucial roles in the interaction with OsExo70-F3, an AVR-Pii-interactor required for Pii-dependent resistance, and in the recognition of AVR-Pii. These results indicate that Pii-ID may function by detecting host accessory protein targeted by pathogen effectors. This finding is different from the known ID function as pathogen effector-interacting domain, and may expand speculated functions of NLR-ID.", "funder_award_id": "26850029", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": "2014-04-01", "end_date": "2017-03-31", "start_year": 2014, "end_year": 2017, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26850029/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Koki", "family_name": "Fujisaki", "orcid": null, "role_start": null, "affiliation": {"name": "Iwate Biotechnology Research Center", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030626510", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088659163", "display_name": "Getting to the Source of Inter-Regional Variation in Patient Flow Performance: A Complex Systems Perspective", "description": null, "funder_award_id": "141802_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 400000.0, "currency": "CAD", "funding_type": "grant", "funder_scheme": "Partnerships for Health System Improvement (PHSI)", "start_date": "2015-06-01", "end_date": "2018-05-31", "start_year": 2015, "end_year": 2018, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Sara", "family_name": "Kreindler", "orcid": null, "role_start": "2015-06-01", "affiliation": {"name": "University of Manitoba", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088659203", "display_name": "MORTALITY AND MORBIDITY IN HEMODIALYSIS PATIENTS", "description": null, "funder_award_id": "5u01dk049264-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "1994-09-30", "end_date": "2001-08-31", "start_year": 1994, "end_year": 2001, "landing_page_url": "https://reporter.nih.gov/project-details/2518442", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MICHAEL", "family_name": "ALLON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF ALABAMA AT BIRMINGHAM", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088660567", "display_name": null, "description": null, "funder_award_id": "5f19is002218-87", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F19", "start_date": "1987-10-01", "end_date": "1988-09-30", "start_year": 1987, "end_year": 1988, "landing_page_url": "https://reporter.nih.gov/project-details/3562699", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "", "family_name": "MISSING", "orcid": null, "role_start": null, "affiliation": {"name": "EAST CENTRAL UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408866895", "display_name": "核内癌遺伝子産物,c-myc蛋白質のDNA複製と転写における機能", "description": "Principal Investigator：有賀 早苗, Project Period (FY)：1989 – 1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (Research Fellowship), Research Field：General medical chemistry", "funder_award_id": "01790506", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (Research Fellowship)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01790506/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408867238", "display_name": "Service Design for Innovation", "description": "Service Design for Innovation (SDIN)-ETN aims to integrate service design and service innovation approaches that are now dispersed into an innovative research training framework; doing so leverages the creative power of service design to foster innovation. Specific objectives are: creating a mass of researchers who can drive widespread application of service design to leapfrog innovation in European organisations; and developing interdisciplinary competences in the key SDIN area and in key service sectors -ICT, public services and utilities. \nSDIN training programme comprises: individual research projects with interdisciplinary supervision (design and management) and non-academic involvement; substantial non-academic training (through hosts and secondments); development of competences in at least one key service sector, with exposure to other sectors; and network wide training with innovative courses, workshops, transferable skills training, and network wide training events. \nA strong consortium with unique combination of expertise will implement SDIN. Academic beneficiaries provide a rich training experience and research competences in service design and service innovation. The three non-academic beneficiaries are innovation leaders in ICT, public services and utilities, providing a rich ground for application of SDIN results to multiple sectors. \nSDIN will have significant impacts on ESRs, partners, and the pursuit of the Innovation Union: SDIN will develop interdisciplinary and multi sectorial competences in ESRs, which are highly valued and have a strong innovation impact on organisations. Beneficiaries will integrate their expertise to build enduring interdisciplinary and multi-sector competences in SDIN. SDIN’s extensive dissemination will ensure that the results achieved are shared with wider communities, thus producing spill over effects to other sectors. SDIN can make a significant and timely contribution to the Innovation Union strategy.", "funder_award_id": "642116", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 2283925.68, "currency": "EUR", "funding_type": "fellowship", "funder_scheme": "H2020 - MSCA-ITN", "start_date": "2015-01-01", "end_date": "2018-12-31", "start_year": 2015, "end_year": 2018, "landing_page_url": "https://cordis.europa.eu/project/id/642116", "doi": "10.3030/642116", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSIDADE DO PORTO", "country": "PT", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088672916", "display_name": "PARENTING AND INFANT ACTIVITY--A MULTICULTURE PERSPECTIVE", "description": null, "funder_award_id": "1z01hd001120-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3756703", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "M H", "family_name": "BORNSTEIN", "orcid": null, "role_start": null, "affiliation": {"name": "CHILD HEALTH AND HUMAN DEVELOPMENT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408867356", "display_name": "Prevention of Statelessness in International Law: A Case Study on Japanese Nationality Law", "description": "Principal Investigator：秋山 肇, Project Period (FY)：2016-04-22 – 2019-03-31, Research Category：Grant-in-Aid for JSPS Fellows, Section：国内, Research Field：International law", "funder_award_id": "16J07839", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2800000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for JSPS Fellows", "start_date": "2016-04-22", "end_date": "2019-03-31", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16J07839/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408867574", "display_name": "Cell-type specific transcriptomics and gene expression variation in Inflammatory Bowel Disease associated Primary Sclerosing Cholangitis", "description": "Primary Sclerosing Cholangitis is a chronic, cholestatic, autoimmune liver disease, which can lead to biliary cirrhosis and end-stage liver failure necessitating liver transplantation. Inflammatory bowel disease (IBD) co-exists in 60-80% of PSC patients, with a unique right-sided distribution and elevated colorectal cancer risk compared to IBD without PSC. Heterogeneity in disease pathophysiology, phenotype and response to treatment are driven by genetic and environmental factors. Genetic discovery through GWAS and immunochip studies has now identified 18 genetic risk loci associated with PSC. This study aims to investigate the immunological importance of these genetic loci by studying differential changes in RNA expression in subsets of peripheral blood T-cells in patients with PSC-IBD in comparison with age, sex, medication and colonic disease distribution-matched matched IBD controls. Immune cells will be isolated from peripheral blood using flow cytometry, followed by RNA seq and correlation with underlying associated SNPs from GWAS studies. This will provide an understanding of how gene expression alters at the immunological level and how this relates to known genetic risk loci, as well as identifying important biological pathways for future therapeutic target.", "funder_award_id": "205260", "funder": {"id": "https://openalex.org/F4320311904", "display_name": "Wellcome Trust", "doi": "10.13039/100010269"}, "amount": null, "currency": null, "funding_type": "grant", "funder_scheme": "Physiology in Health and Disease", "start_date": "2016-05-01", "end_date": "2019-04-30", "start_year": 2016, "end_year": 2019, "landing_page_url": "https://europepmc.org/grantfinder/grantdetails?query=pi:\"%7BDr%7D%7BGoode%7D%7BElizabeth%7D%7BE%7D\" gid:\"205260\" ga:\"Wellcome Trust\"", "doi": "http://dx.doi.org/10.35802/205260", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088680663", "display_name": "Collaborative Research: Investigating Holocene Paleoclimate In TheWestern Arctic Ocean Using Very High-Resolution Marine Records Off Alaska", "description": "ABSTRACT\r\nDarby\r\nOPP-0612493\r\nBrachfield\r\nOPP-: 0612365 \r\nPolyak\r\nOPP-0612384\r\nOrtiz\r\nOPP-0612473\r\n\r\nIntellectual Merit: Understanding how the climate system functions and how it might change, especially in the climate-sensitive Arctic Ocean, is of paramount importance and could be achieved through high-resolution paleo-records. Until the Healy-Oden Trans-Arctic Expedition (HOTRAX'05), such records in the Arctic Ocean were very rare. HOTRAX not only recovered several high-resolution records from the Alaskan margin, but also plankton tows for isotopic calibration of foraminifer, and samples of porewater collected under hermetic conditions for calibration of important proxies such as pyrite and monosulfides as potential indicators of paleoproductivity. Many proxies will be measured in the research including: sediment reflectivity, biogenic components (foraminifer, dinocysts, etc.), nutrients, stable isotopes and cadmium/calcium and magnesium/calcium in foraminiferal tests, and iron oxide fingerprinting of ice rafted debris for sea ice sources and drift patterns. Age models and detailed core correlation will be of primary concern initially and involve several approaches including AMS carbon-14, paleomagnetics, and lead-210. The objective will be to establish paleoclimate records for the Holocene for the HOTRAX cores along the continental shelf margin north of Alaska in a critical zone for the confluence and impact of different water masses. These cores should be impacted by many of the important influxes that might affect or record climate change in the western Arctic Ocean, such as the Mackenzie River and other drainage systems, the Bering Strait influx of Pacific waters, and the sub-surface influx of North Atlantic Intermediate water. These cores are ideal for recording sea ice input events from Russian Shelves into the Beaufort Gyre presumably in response to fluctuations in the Arctic Oscillation. Therefore, several proxies will be employed to measure the important environmental and climatic changes that should be recorded in these very high resolution HOTRAX cores.\r\n\r\n Broader Impacts: This research interfaces and fulfills many aspects of existing research initiatives such as the Study of Arctic environmental change (SEARCH), western Arctic Shelf-Basin Interactions (SBI), and paleoclimate component of the International Committee for Arctic Paleo Projects (ICARP) and its International Polar Year (IPY) affiliation. In addition, the results of this research could have important implications for residents of the north slope of Alaska with the focus on freshwater inputs and Russian ice to the waters offshore. Several graduate and undergraduate students will be involved. Many of the findings will be incorporated into courses taught by the investigators and talks to professional and community groups. More significantly, there will be opportunities for underrepresented minority students to participate and contribute to the proposed research through Old Dominion University's (ODU) Minority Undergraduate Scholarship and Training REU program (NSF-funded) and the joint ODU-Hampton University-Virginia Institute of Marine Sciences' Hall-Bonner Program for Minority Doctoral Scholars in Ocean Sciences (a NSF-funded Diversity in Geosciences grant). Collaboration with Teachers and Researchers Exploring and Collaborating (TREC) earth science teachers, begun on the HOTRAX cruise, will continue as part of this project with the development of small research exercises for the students that will be part of a website for use by similar teachers world-wide.\r\n\r\n", "funder_award_id": "0612493", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 423725.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2006-10-01", "end_date": "2011-09-30", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0612493", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Dennis", "family_name": "Darby", "orcid": null, "role_start": null, "affiliation": {"name": "Old Dominion University", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088681284", "display_name": "Anti-CTGF Therapy for Squamous Cell Lung Cancer", "description": "PUBLIC HEALTH RELEVANCE Individualized therapeutics for squamous cell lung cancer are nonexistent. Recently, we have identi- fied activation of the transcription factor SOX2 in a portion of human squamous cell lung cancers. A downstream target of SOX2 that may be clinically relevant and therapeutically attractive is connective tissue growth factor (ctgf). We propose to test inhibition of CTGF as a therapeutic strategy in SOX2+ squamous cell lung cancer. ", "funder_award_id": "1r21ca201486-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 207495.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2016-01-12", "end_date": "2016-07-31", "start_year": 2016, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/9016047", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARK", "family_name": "ONAITIS", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088686954", "display_name": "TAS::89 0336::TAS RECOVERY RESEARCHERS AT GEORGIA TECH WILL INCORPORATE METAL ORGANIC FRAMEWORKS (MOFS), NEW COMPOUNDS THAT SHOW GREAT PROMISE IN", "description": "TAS::89 0336::TAS RECOVERY RESEARCHERS AT GEORGIA TECH WILL INCORPORATE METAL ORGANIC FRAMEWORKS (MOFS), NEW COMPOUNDS THAT SHOW GREAT PROMISE IN", "funder_award_id": "DEAR0000074", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 1998929.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "ADVANCED RESEARCH AND PROJECTS AGENCY - ENERGY FINANCIAL ASSISTANCE PROGRA", "start_date": "2010-07-01", "end_date": "2012-10-31", "start_year": 2010, "end_year": 2012, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_DEAR0000074_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088692775", "display_name": "Biosensor Biocompatibility", "description": null, "funder_award_id": "2r01dk054932-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 265458.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1999-02-15", "end_date": "2008-06-30", "start_year": 1999, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/6546346", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WILLIAM MONTGOMERY", "family_name": "REICHERT", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088696797", "display_name": "Reconstructing Afghanistan: the manufacture of concrete and the durability of war", "description": null, "funder_award_id": "84847", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 40000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "SSHRC Doctoral Awards", "start_date": "2021-04-01", "end_date": null, "start_year": 2021, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Habib, Hala", "orcid": null, "role_start": null, "affiliation": {"name": "Grantee", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088699134", "display_name": "TLR4 and murine ischemic acute renal failure", "description": null, "funder_award_id": "1r01dk069633-01a2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 321850.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2006-08-04", "end_date": "2011-05-31", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7145513", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHRISTOPHER Y.", "family_name": "LU", "orcid": null, "role_start": null, "affiliation": {"name": "UT SOUTHWESTERN MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088702292", "display_name": "Cancer Biology Training Program", "description": null, "funder_award_id": "5t32ca111198-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 369390.0, "currency": "USD", "funding_type": "training", "funder_scheme": "T32", "start_date": "2005-04-01", "end_date": "2010-03-31", "start_year": 2005, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7447328", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANN", "family_name": "ROMAN", "orcid": null, "role_start": null, "affiliation": {"name": "INDIANA UNIVERSITY INDIANAPOLIS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088703138", "display_name": "SBIR Phase I: Automated detection, classification, and motion tracking of precipitation and insects for agricultural, health, and transport safety applications.", "description": "The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to address consumer weather, and agricultural information needs as an advanced precipitation sensor and as a fully automated detector and classifier of insect species. Information on hydrometeor rate and type is critical for transportation safety and weather prediction. Wet snow and freezing rain events count among the worst natural disasters in North American history; the proposed device will be the first with the unambiguous capability for providing reliable remote detection of particles in a semi-frozen state for transportation management. Further, insect number, species, and motion vectors are critical for targeted pesticide applications that prevent the spread of disease and crop damage while preventing off-target damages to vulnerable species, such as bees. The combined commercial damages from precipitation and agricultural pests in the United States exceed $100 billion annually. \r\n\r\nThe proposed project will exploit recent advances in lighting, digital imaging, motion detection, and image processing to develop a new Small Airborne Particle Imager for obtaining high-resolution forward-illuminated photography of precipitation particles, as well as insects and their trajectories. The goal is to create a device capable of detecting and photographing objects moving up to 10 m/s at resolutions as fine as 0.01 mm. Primary components of the Phase I effort involve the integration of multi-spectral, multi-polarization photography and design of a novel motion detection system capable of providing 3D motion vectors of objects 0.1 mm across.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "1940212", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 223956.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2019-12-15", "end_date": "2021-05-31", "start_year": 2019, "end_year": 2021, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1940212", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Allan", "family_name": "Reaburn", "orcid": null, "role_start": null, "affiliation": {"name": "Particle Flux Analytics, Inc", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088703600", "display_name": "An Atomic Absorption Spectrometer for Undergraduate Environmental Studies in Biology and Chemistry", "description": "Goucher College will buy an atomic absorption spectrometer (AA). The AA will be used in a variety of upper level chemistry and biology courses, and it will also be the major piece of equipment used in six week intensive projects, where chemistry and biology students join forces to investigate the uptake of heavy metals in aquatic organisms. This project will simulate the interaction of biologists and chemists typical of research or industrial settings and will require both independence and communications skills. This project may serve as a model for cooperative teaching between disciplines where shared expertise is focused on different aspects of the same question. After receiving background in toxicology and instrumental analysis respectively, the biology and chemistry students will join forces. Biology students will formulate the basic questions about metal uptake and toxicity and then consult their chemist peers to develop the experimental design and analytical protocol for metal analysis in tissues using the AA. The biology and chemistry students will then analyze the samples and interpret the data together. This is an excellent place for students to experience the benefits of modern computer interfaced instrumentation, for it will greatly affect their ability to answer scientific questions. The sensitivity of the AA will permit detection of trace levels of metals in the environment or in tissues. Sample automation will allow enough samples for thorough data analysis, which will in turn be greatly facilitated by the onboard graphics and data management software of the AA.", "funder_award_id": "8750765", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 22107.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1987-06-15", "end_date": "1989-11-30", "start_year": 1987, "end_year": 1989, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=8750765", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Esther", "family_name": "Gibbs", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408870387", "display_name": "低体温療法の脳保護作用機序", "description": "Principal Investigator：黒田 泰弘, Project Period (FY)：1992, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：麻酔学", "funder_award_id": "04771093", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1992-04-01", "end_date": "1992-03-31", "start_year": 1992, "end_year": 1992, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04771093/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088704603", "display_name": "PDT: Mechanisms and Strategies for Optimization", "description": null, "funder_award_id": "5p01ca055791-13", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 2184433.0, "currency": "USD", "funding_type": "program", "funder_scheme": "P01", "start_date": "1992-09-30", "end_date": "2008-04-30", "start_year": 1992, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/6879529", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ALLAN R", "family_name": "OSEROFF", "orcid": null, "role_start": null, "affiliation": {"name": "ROSWELL PARK CANCER INSTITUTE CORP", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088705976", "display_name": "PGSB/ESB", "description": "No summary - Aucun sommaire", "funder_award_id": "222222-1999", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 19100.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Postgraduate Scholarships", "start_date": "2000-04-01", "end_date": "2001-03-31", "start_year": 2000, "end_year": 2000, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=222222-1999", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Robert", "family_name": "McDonald", "orcid": null, "role_start": null, "affiliation": {"name": "McMaster University", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088706289", "display_name": "Small Animal Ultrasound Imager - Vevo 2100", "description": "PUBLIC HEALTH RELEVANCE STATEMENT: We are requesting funds to purchase a Vevo2100 ultrasound system for small animal imaging. This state-of the-art system would enable us to obtain highly accurate measures of cardiac, renal and pulmonary function, and would aid in oncology research, biomarker discovery and contrast imaging. This would be the only Vevo2100 instrument in the University of Colorado system and would enhance NIH funded research across the Denver metropolitan area. ", "funder_award_id": "1s10od018156-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 505719.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "S10", "start_date": "2014-07-01", "end_date": "2015-06-30", "start_year": 2014, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8640699", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "PETER N.", "family_name": "BUTTRICK", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO DENVER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408870786", "display_name": "THE PURPOSE OF THIS GRANT IS TO PROVIDE ASSISTANCE FOR THE ACQUISITION OF SEXUALLY TRANSMITTED INFECTION (STI) TESTING SERVICES FOR THE COUNTRY OF GU", "description": "THE PURPOSE OF THIS GRANT IS TO PROVIDE ASSISTANCE FOR THE ACQUISITION OF SEXUALLY TRANSMITTED INFECTION (STI) TESTING SERVICES FOR THE COUNTRY OF GU", "funder_award_id": "N681711510001", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 2285.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "DEPARTMENT OF DEFENSE HIV/AIDS PREVENTION PROGRAM", "start_date": "2014-10-16", "end_date": "2014-12-31", "start_year": 2014, "end_year": 2014, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_N681711510001_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088712028", "display_name": "蓄電池製造作業者の歯牙酸蝕症に関する衛生学的研究", "description": "Principal Investigator：須山 祐之, Project Period (FY)：1990, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：小児・社会系歯学", "funder_award_id": "02771630", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 800000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1990-04-01", "end_date": "1990-03-31", "start_year": 1990, "end_year": 1990, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02771630/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408871275", "display_name": "Synaptic Mechanisms in an in vitro Model of Developmental Epilepsy", "description": null, "funder_award_id": "5k08ns054882-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 176094.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K08", "start_date": "2006-04-01", "end_date": "2011-03-31", "start_year": 2006, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7800306", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES W. M", "family_name": "OWENS", "orcid": null, "role_start": null, "affiliation": {"name": "BAYLOR COLLEGE OF MEDICINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088714090", "display_name": "Multi-wavelength studies of X-ray binaries", "description": null, "funder_award_id": "119489", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 93160.0, "currency": "CHF", "funding_type": "fellowship", "funder_scheme": "Fellowships for advanced researchers", "start_date": "2009-02-01", "end_date": "2010-09-30", "start_year": 2009, "end_year": 2010, "landing_page_url": "https://data.snf.ch/grants/grant/119489", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Zurita, Juan", "family_name": "Antonio", "orcid": null, "role_start": null, "affiliation": {"name": "Institution abroad - France", "country": "France", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088716426", "display_name": "MACULAR PHOTOCOAGULATION STUDY", "description": null, "funder_award_id": "5u10ey002563-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U10", "start_date": "1979-09-30", "end_date": "1993-12-31", "start_year": 1979, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3559093", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RAYMOND R", "family_name": "MARGHERIO", "orcid": null, "role_start": null, "affiliation": {"name": "WILLIAM BEAUMONT HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088718603", "display_name": "Study on clinical significance as the pancreatic cancer high-risk group by salivary metabolomics analysis for diabetes patients", "description": "膵癌は初期に自覚症状がなく大部分が進行時に発見されるため、生存率が他の癌に比べ極めて低い。このため簡単で侵襲の少ないスクリーニング方法の確立が急務である。これまでの唾液の代謝物の解析で、膵癌の早期でも変化する代謝産物を見出してきた。本研究では、これらの基礎研究に基づく臨床研究を行うと同時に、より高精度の検出方法を開発する。臨床的観点では、近年欧米で糖尿病患者の一部が膵癌ハイリスクグループであるとする疫学調査、研究が行われ報告されていることから、日本人に多い糖尿病患者を対象に膵癌スクリーニングシステムの構築を図る。", "funder_award_id": "20K07633", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4420000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2020-04-01", "end_date": "2025-03-31", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K07633/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "博充", "family_name": "川井田", "orcid": null, "role_start": null, "affiliation": {"name": "University of Yamanashi", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000000345711", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088719350", "display_name": "Engineering zonal human liver functions in vitro using microfluidics", "description": "PUBLIC HEALTH RELEVANCE: Zonal heterogeneity in hepatic functions is an important feature of the liver; however, how various factor gradients modulate zonal hepatic functions in the human liver, and what role liver stromal cells play in such modulation is not well understood. This project will utilize microfluidics technology to investigate the effects of liver-relevant facor gradients and liver stromal cells on zonal functions of primary human hepatocytes in culture. Creating approaches and design rules for making a heterogeneous and stable population of human liver cells will allow recapitulation of this important liver feature in systems designed for drug screening, clinical use (i.e. bioartificial liver devices), and stem cell differentiation. ", "funder_award_id": "1r03eb019184-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 81719.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R03", "start_date": "2014-09-22", "end_date": "2016-06-30", "start_year": 2014, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8773296", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SALMAN R", "family_name": "KHETANI", "orcid": null, "role_start": null, "affiliation": {"name": "COLORADO STATE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088720529", "display_name": "CAREER: Enabling Human-Aware and Responsive Automation through Cognitive State Modeling and Estimation", "description": "This Faculty Early Career Development Program (CAREER) grant will fund research that enables autonomous systems such as machines, robots, and vehicles, to respond safely and collaboratively to human interactions, thereby promoting the progress of science, and advancing the national prosperity and welfare. Significant increases in automation are expected across the healthcare, manufacturing, and transportation sectors. Major challenges to the safe integration of automation in situations involving human participants are the lack of accurate mathematical models of human behavior, intent, and cognitive state, as well as of reliable ways of gathering relevant real-time data from humans. This project overcomes these challenges by building a new modeling framework that accounts for human cognitive constructs established within the social sciences, such as trust, workload, perceived risk, and self-confidence, while being amenable to rigorous mathematical analysis. It demonstrates how this framework can facilitate the design of sensing and control algorithms that can allow an autonomous system to determine, for example, how confident the human is in taking over a task, say during driving of an autonomous vehicle. Through close integration of research and education, the project will train engineering students to tackle questions surrounding socio-political and ethical challenges associated with the rapid expansion of automation in society. This will be achieved through new interdisciplinary coursework and recurrent immersive learning experiences that bring students together with state and federal policymakers. \r\n\r\nThis research aims to develop the foundations of a control-theoretic framework for human-automation interaction that can use real-time data to continually improve prediction accuracy. It achieves this aim by defining a human cognitive state space and characterizing its dynamics in a model formulation that is compatible with standard tools of control design. A unique feature of this formulation is its interpretability, maintained by grounding the model in established conceptual frameworks governing human decision-making. A principled methodology for real-time parameter and cognitive state estimation will be created that blends information from multiple sensors with different capabilities and costs of querying, and enables adaptation to different individuals. A generalizable technique for exciting human cognitive dynamics, as well as guidelines for choosing the cognitive state estimation algorithm best suited for a particular human-automation interaction context, will be established. Laboratory and field experiments, including tests using trucks equipped with Level 1 driver assistance features, are planned for validation of the modeling framework and estimation algorithms.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2145827", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 673782.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2022-09-01", "end_date": "2027-08-31", "start_year": 2022, "end_year": 2027, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2145827", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Neera", "family_name": "Jain", "orcid": null, "role_start": null, "affiliation": {"name": "Purdue University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088722276", "display_name": "Strengthening community capacity for HIV prevention and care among African Caribbean and Black (ACB) women in Ontario: An interdisciplinary community-based participatory research initiative", "description": "In Ontario, African, Caribbean, and Black (ACB) women are overrepresented among new HIV diagnoses. This overrepresentation of ACB women is believed to be in part due to social and structural factors, such as HIV-related stigma, gender discrimination, and racial discrimination, which converge to increase vulnerability to HIV infection by reducing access to HIV prevention and care. Given the disproportionate burden of HIV infection among ACB women, the development of HIV interventions to respond to these increased risks is vital. The project builds on three recently completed CIHR- funded studies lead by the PI which include infant feeding practices of ACB women living with HIV, HIV vulnerability and resilience among ACB men and ACB HIV Monitoring and Surveillance. They highlight the need for critical health and racial literacy among providers and community members. Critical health and racial literacy interventions are increasingly being used to promote health especially in the current context of COVID-19 and co-morbidities like HIV. Peer-led programs can be an effective strategy for reaching at-risk populations. Scholars further recognize that ACB communities need to be involved in interventions addressing health inequities. This study seeks to create, implement, and evaluate an ACB community-based peer-led intervention to improve access to HIV prevention and care for ACB women in Ontario. Community-based participatory research (CBPR), guided by intersectionality lens, implementation science and evaluation frameworks will be used to guide the project. The project consists of 5 phases over a 5-year period and builds on a record of inspired and innovative HIV-related work in ACB communities led by ACB women scholars. Evidence on the effectiveness of this innovative, peer-led intervention can be used to inform policies and practice related to HIV prevention and care for ACB women in Canada.", "funder_award_id": "183803_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 1015652.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Project Grant", "start_date": "2022-10-01", "end_date": "2027-09-30", "start_year": 2022, "end_year": 2027, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Josephine", "family_name": "Etowa", "orcid": null, "role_start": "2022-10-01", "affiliation": {"name": "University of Ottawa", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408872353", "display_name": "Preparing a computerized tool for preventing prenatal drinking for a larger trial", "description": "PUBLIC HEALTH RELEVANCE: Heavy drinking by women of childbearing age increases risk for unplanned pregnancy, for drinking during pregnancy, and for fetal alcohol spectrum disorders in their infants. We will adapt an innovative, self- administered computerized screening and brief intervention for drinking during pregnancy for use with non- pregnant childbearing age women, and test its efficacy in a small trial. Study findings will inform a larger randomized control trial for a primary prevention tool with the potential for broad health impact.", "funder_award_id": "5r34aa022697-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 231450.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R34", "start_date": "2014-09-01", "end_date": "2018-08-31", "start_year": 2014, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/9121374", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MADHABIKA", "family_name": "NAYAK", "orcid": null, "role_start": null, "affiliation": {"name": "PUBLIC HEALTH INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088725724", "display_name": "CHARACTERIZATION &CLONING OF LEISHMANIA ANTIGENS", "description": null, "funder_award_id": "5r01ai019347-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1983-01-01", "end_date": "1993-01-31", "start_year": 1983, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3128717", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "EMANUELA", "family_name": "HANDMAN", "orcid": null, "role_start": null, "affiliation": {"name": "ROYAL MELBOURNE HOSPITAL", "country": "AUSTRALIA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408872585", "display_name": "Effect of environmental changes on diversity and functions of soil microbes in peat lands.", "description": "In mires, plant residues become into peat under low temperature and high moisture level condition. Decomposition rate of organic matter is very low and, and nutrients become available very slowly depending on the rate of mineralization, through which cellulose decomposing bacteria play an important roll. In such an oligotrophic ecosystem, moisture level, mineral supply, quality of substrate and other physical and chemical factors, which influence the decomposition rate, are changed recently by natural and artificial sources. In the present study, cellulose decomposing bacteria were isolated from geographically various type of mire in three areas in Japan, to reveal its functional diversity with following results :Mainly single cell forming bacteria was isolated from Sphagnum mat in highland moor, whereas small number of such bacteria was isolated from peat soil in forest and reed marsh, where mainly actinomycetes was dominant as cellulose decomposing bacteria. The isolated single cell bacteria were examined C-substrate utilization patterns by Biolog system and classified functionally different groups. Isolates from sphagnum mat used many kinds of hydrocarbons and small number of organic acids and amino compounds, whereas isolates from peat soil in a forest used limited hydrocarbons and some kinds of carboxylic acids and amino compounds as C-substrate. These results might reflect the difference of potential C-substrates in the habitats where the isolates living wetland soils.", "funder_award_id": "16510030", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3400000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16510030/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Hiroki", "family_name": "MIKIYA", "orcid": null, "role_start": null, "affiliation": {"name": "National Institute for Environmental Studies", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000040142103", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088726123", "display_name": "PATHOGENESIS OF OPHIDIAN PARAMYXOVIRUS INFECTION IN BROWN TREE SNAKES", "description": null, "funder_award_id": "1z01rr000095-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3849461", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "E", "family_name": "WOO", "orcid": null, "role_start": null, "affiliation": {"name": "RESEARCH RESOURCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088727122", "display_name": "Relaxation, Intermittency and Dissipation in a Collisionless Plasma", "description": "The purpose of this project is to improve understanding of the basic science of turbulence in a plasma. Turbulence is the complex dynamics of a fluid or gas resulting from nonlinear forces that span a wide range of scales in space and time. Many important effects emerge from turbulence, such as mixing and rapid transport of heat and energy; this influences terrestrial fluids as well as electrically conducting gases, or plasmas, in space and on the sun. Turbulence is usually not uniform in space – it tends to quickly self-organize into irregularly shaped \"cells.\" Inside these cells the plasma is typically quiescent, but the thin boundaries between cells are highly active with sometimes explosive results. Processes causing this self-organization and formation of the cell boundaries are studied in this project. This effort will support a post-doctoral researcher and advance understanding of many observed space plasma phenomena, including solar flares and variability of turbulence in the solar wind, thus contributing to the science underlying space weather.\r\n\r\nRelaxation processes, turbulence cascade and dissipation mechanisms are each an important area of study in plasma physics and its applications. However these are most frequently studied separately. The fundamental hypothesis advanced in this project is that the nature of the intermittent cascade, and the dissipation that it leads to, are strongly influenced by specific relaxation processes that originate at the energy containing scales. In particular, local relaxation leads to spatial cellularization, and the associated spatial nonuniformity controls the formation of coherent structures, where dissipation is expected to be greatly enhanced. This has been studied, although incompletely, in fluid plasma models such as magnetohydrodynamics, but is poorly understood in fully kinetic plasma models to be considered within this project. Establishing such fundamental connections as parameters are changed to vary among modes of relaxation will advance understanding of fundamental plasma physics.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2108834", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 680000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2021-06-15", "end_date": "2027-05-31", "start_year": 2021, "end_year": 2027, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2108834", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "William", "family_name": "Matthaeus", "orcid": null, "role_start": null, "affiliation": {"name": "Department of Physics and Astronomy, University of Delaware", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088728729", "display_name": "High performance compound semiconductor nanowire optoelectronic devices", "description": "Semiconductor nanowires are emerging nano-materials with substantial opportunities for novel photonic and electronic device applications. This project aims at developing a new generation of high performance nanowire-based light-emitting diodes (LEDs), lasers and photodetectors, which will make great contribution to the nation in the areas of science, technology and industry.", "funder_award_id": "FT110100754", "funder": {"id": "https://openalex.org/F4320334704", "display_name": "Australian Research Council", "doi": "10.13039/501100000923"}, "amount": 763659.0, "currency": "AUD", "funding_type": "fellowship", "funder_scheme": "ARC Future Fellowships", "start_date": "2011-01-01", "end_date": "2017-06-30", "start_year": 2011, "end_year": 2017, "landing_page_url": "https://dataportal.arc.gov.au/RGS/Web/Grants/FT110100754", "doi": null, "provenance": "arc", "lead_investigator": {"given_name": "Lan", "family_name": "Fu", "orcid": null, "role_start": null, "affiliation": {"name": "The Australian National University", "country": "Australia", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088730616", "display_name": "Collaborative Research on Mediterranean \"Cobblestone\" Topography: Origin and Significance", "description": null, "funder_award_id": "7719646", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 69500.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "1978-03-15", "end_date": "1980-11-30", "start_year": 1978, "end_year": 1980, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7719646", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "William", "family_name": "Ryan", "orcid": null, "role_start": null, "affiliation": {"name": "DATA NOT AVAILABLE", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088732535", "display_name": "Automatic Coding of Therapist and Client Language in Motivational Interviewing to Predict Reductions in Alcohol Use and Problems Using Machine-based Dyadic Multimodal Representation Learning", "description": "Current analyses of Motivational Interviewing (MI) process are limited to investigations pertaining to language only and are restricted by expensive and arduous manual coding which, despite the time and efforts expended to achieve reliability, may still not be sufficiently sensitive or specific to adequately test the complex theoretical propositions espoused by MI theorists. Our project introduces a computational framework that aims to jointly analyze verbal (i.e., what is being said), nonverbal (i.e., how something is said), and dyadic (i.e., in what interpersonal context something is said) behavior to better predict in- session change talk and sustain talk and subsequent changes in post-session alcohol use. We will leverage already collected and annotated data from two NIAAA-funded single-session MI randomized clinical trials to improve drinking behavior (N=99 and N=193) and validate the generalizability of our computational framework using seven additional NIAAA- and federally funded RCTs that used different MI protocols for different target populations.", "funder_award_id": "5r01aa027225-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 519211.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2019-09-01", "end_date": "2024-08-31", "start_year": 2019, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10473711", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEFAN", "family_name": "SCHERER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF SOUTHERN CALIFORNIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408873390", "display_name": "A biochemical approach to stomatin function", "description": null, "funder_award_id": "P22038", "funder": {"id": "https://openalex.org/F4320321181", "display_name": "Austrian Science Fund", "doi": "10.13039/501100002428"}, "amount": 213129.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": null, "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://www.fwf.ac.at/en/research-radar/10.55776/P22038", "doi": "http://dx.doi.org/10.55776/p22038", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088738852", "display_name": "Parent-offspring interactions and conflict in tree swallows", "description": "No summary - Aucun sommaire", "funder_award_id": "184188-1996", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 33495.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Women's Faculty Awards (H)", "start_date": "1999-04-01", "end_date": "2000-03-31", "start_year": 1999, "end_year": 1999, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=184188-1996", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Martha", "family_name": "Leonard", "orcid": null, "role_start": null, "affiliation": {"name": "Dalhousie University", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088742621", "display_name": "Melatonin, behavior and neuronal activity", "description": null, "funder_award_id": "5r01mh065528-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 269172.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-07-01", "end_date": "2007-04-30", "start_year": 2003, "end_year": 2007, "landing_page_url": "https://reporter.nih.gov/project-details/6909065", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "IRINA V.", "family_name": "ZHDANOVA", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088742818", "display_name": "PostDoctoral Research Fellowship", "description": "This award is made as part of the FY 2017 Mathematical Sciences Postdoctoral Research Fellowships Program. Each of the fellowships supports a research and training project at a host institution in the mathematical sciences, including applications to other disciplines, under the mentorship of a sponsoring scientist. The title of the project for this fellowship to Erin Compaan is \"Dynamics of dispersive partial differential equations: Applications of harmonic analysis and probabilistic methods.\" The host institution for the fellowship is Massachusetts Institute of Technology, and the sponsoring scientist is Gigliola Staffilani.", "funder_award_id": "1704865", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 150000.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "Fellowship Award", "start_date": "2017-08-01", "end_date": "2021-07-31", "start_year": 2017, "end_year": 2021, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1704865", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Erin", "family_name": "Compaan", "orcid": null, "role_start": null, "affiliation": {"name": "Massachusetts Institute of Technology", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088743882", "display_name": "2007 Fall Workshop on Computational Geometry", "description": "The 2007 Fall Workshop in Computational Geometry is being held at the IBM T.J. Watson Research Center in Hawthorne, New York. The workshop is jointly organized by Richard Pollack and Janos Pach of the Courant Institute of NYU, and Jonathan Lenchner of IBM and Polytechnic University, Brooklyn. The aim of the workshop is to bring together researchers from academia and industry, to stimulate collaboration on problems of common interest arising in geometric computing. Holding the workshop at IBM is intended to infuse the field of computational geometry with a set of fresh problems, and problem areas, coming from contemporary industrial applications. Following the tradition of the previous workshops on Computational Geometry, the format of the workshop is informal, extending over two days, with several breaks scheduled for discussions. There are invited speakers and an open problem session to promote a free exchange of questions and research challenges. \r\n\r\n", "funder_award_id": "0735377", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 8000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2007-09-01", "end_date": "2008-08-31", "start_year": 2007, "end_year": 2008, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0735377", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Richard", "family_name": "Pollack", "orcid": null, "role_start": null, "affiliation": {"name": "Courant Institute of Math Sciences", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088747068", "display_name": "Multi-ethnic Multi-level Strategies and Behavioral Economics to Eliminate Hypertension Disparities in LA County.", "description": "Project Narrative Eliminating racial/ethnic cardiovascular health disparities in the U.S. cannot be achieved without addressing disparities in evidence-based treatment of hypertension. In the Los Angeles County Department of Health Services (LAC DHS), the second largest municipal health system in the US, patient, clinician, healthy system, and community factors contribute to substantial disparities in hypertension prevalence, control, and outcomes by race/ethnicity. In this study, we use innovative methods in implementation science, community engagement, and behavioral economics to develop and deploy culturally-tailored, multi-level, sustainable implementation strategies that improve blood pressure control and reduce hypertension-related health disparities.", "funder_award_id": "4uh3hl154302-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1091835.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "UH3", "start_date": "2020-09-10", "end_date": "2027-08-31", "start_year": 2020, "end_year": 2027, "landing_page_url": "https://reporter.nih.gov/project-details/10723249", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ARLEEN F.", "family_name": "BROWN", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088747310", "display_name": "Tyre-fix installation system", "description": "Eco-Motive Products Limited are working to develop a delivery system for Tyre-fix, is an environmentally friendly tyre sealant, which allows customers with no mechanical training or knowledge to install ‘Tyre-fix’ into all their tyres easily and quickly with no mess.", "funder_award_id": "752838", "funder": {"id": "https://openalex.org/F4320335087", "display_name": "Innovate UK", "doi": "10.13039/501100006041"}, "amount": null, "currency": "GBP", "funding_type": "grant", "funder_scheme": "Vouchers", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://gtr.ukri.org/projects?ref=752838", "doi": null, "provenance": "innovate_uk", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "Eco-Motive Manufacturing Limited", "country": "United Kingdom", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088748772", "display_name": "Common Pathogenic Pathways and Therapeutics for SMA and ALS motoneuron diseases", "description": "Spinal muscular atrophy (SMA) is an incurable paralytic neuromuscular disorder that mainly affects children at an incidence of 1 in 6000 to 10000 births. SMA is characterized by the selective degeneration of spinal motoneurons. About 95% of SMA cases are caused by autosomal loss-of-function mutations in the SMN1 gene. Recent work has shown that SMA and amyotrophic lateral sclerosis (ALS), another devastating motoneuron pathology, share converging aberrant pathways. The motoneuron-restricted death pathway triggered by Fas and its ligand FasL, contributes to the loss of motoneurons in ALS. Our preliminary data shows that Fas is markedly upregulated in spinal cord motoneurons of SMA mice, suggesting that Fas may also contribute to SMA pathogenesis. Additional preliminary data demonstrates that whereas Fas undeniably induces motoneuron death, it also promotes neuronal outgrowth. Therefore, the same factor may be implicated in compensatory axonal plasticity as well as in the selective loss of neurons. Here, we propose to further dissect the functional duality of Fas and investigate the contribution of the Fas pathway in SMA pathogenesis. Activation and expression profile of the Fas pathway will be assessed in Smn-depleted motoneurons, in a SMA mouse model and in human SMA spinal cord. Further, gene therapy approaches will be developed to reduce Fas activity in the spinal cord and specifically target FasL to axons in SMA mice. The ultimate goal of this collaborative endeavor is to generate common therapeutic strategies for SMA and ALS, as well as for other motoneuron diseases.", "funder_award_id": "138414_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 390150.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Operating Grant - E-Rare-2: Development of Innovative Therapeutic Approaches for Rare Diseases", "start_date": "2015-04-01", "end_date": "2018-03-31", "start_year": 2015, "end_year": 2018, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Rashmi", "family_name": "Kothary", "orcid": null, "role_start": "2015-04-01", "affiliation": {"name": "Ottawa Hospital Research Institute", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088749725", "display_name": "Illumination of Immune Checkpoint Therapy of Cancer: Molecular Imaging of Immunity with Copper Radiopharmaceuticals", "description": "Exciting developments in the treatment of cancer have involved developing ways to reinvigorate a patient’s own immune system to attack their disease. This type of therapy, called immune checkpoint therapy, produces remarkable outcomes for some patients but some do not respond. This research will develop the chemistry required to produce imaging agents to enable clinicians to identify patients suitable for immune checkpoint therapies using non-invasive Positron Emission Tomography (PET) imaging. ", "funder_award_id": "2011853", "funder": {"id": "https://openalex.org/F4320334705", "display_name": "National Health and Medical Research Council", "doi": "10.13039/501100000925"}, "amount": 515103.0, "currency": "AUD", "funding_type": "research", "funder_scheme": "Ideas Grants - Ideas Grants", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": null, "doi": null, "provenance": "nhmrc", "lead_investigator": {"given_name": "Paul", "family_name": "Donnelly", "orcid": null, "role_start": null, "affiliation": {"name": "University of Melbourne", "country": "Australia", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088751019", "display_name": "Konstruktion von numerischen Verfahren hoher Ordnung für hyperbolische partielle Differentialgleichungen in komplizierten Gebieten", "description": "Dieses Projekt befasst sich mit der Konstruktion von Finiten-Volumen-Verfahren für hyperbolische partielle Differentialgleichungen unter Verwendung von kartesischen Gittern mit geschnittenen Zellen.Viele Anwendungen erfordern die Lösung hyperbolischer Probleme in komplizierten Geometrien. Die Gittererzeugung ist eine grundlegende Komponente eines Finiten-Volumen-Verfahrens. Traditionell verwendet man entweder ein strukturiertes gebietsfolgendes Gitter oder ein unstrukturiertes Gitter. Beide Ansätze erfordern einen erheblichen Aufwand bei der Gittergenerierung. Ein alternativer Ansatz ist die Verwendung eines kartesischen Gitters mit geschnittenen Zellen. Ein solcher Ansatz erlaubt eine einfache Gittererzeugung selbst bei sehr komplizierten Gebieten. Im Inneren des Gebietes werden Verfahren für kartesische Gitter verwendet, die typischerweise einfacher und genauer sind als entsprechende Verfahren für unstrukturierte Gitter. In den geschnittenen Gitterzellen muss das Finite-Volumen-Verfahren allerdings modifiziert werden, um Stabilitätsprobleme aufgrund der mitunter sehr kleinen geschnittenen Gitterzellen zu vermeiden. Es zeigt sich, dass Genauigkeit entlang der geschnittenen Zellen neben dem Stabilitätsproblem die größere Schwierigkeit darstellt. In diesem Projekt entwickeln wir das erste Finite-Volumen-Verfahren dritter Ordnung für kartesische Gitter mit geschnittenen Zellen. Wir entwickeln dieses Verfahren in Anlehnung an Active Flux Verfahren, einer neue Klasse Finiter-Volumen-Verfahren mit kompaktem Träger, die auf der Berechnung von Zellmittelwerten sowie Punktwerten der Erhaltungsgröße beruhen.", "funder_award_id": "325695158", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 109941.6654, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "2016-01-01", "end_date": "2016-12-31", "start_year": 2016, "end_year": 2016, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/325695158", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088753899", "display_name": "AMPHIBIAN METAMORPHOSIS: A DEVELOPMENTAL PROGRAM", "description": null, "funder_award_id": "2r01gm022395-29", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 362000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1975-09-01", "end_date": "2008-03-31", "start_year": 1975, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/6770958", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DONALD D", "family_name": "BROWN", "orcid": null, "role_start": null, "affiliation": {"name": "CARNEGIE INSTITUTION OF WASHINGTON, D.C.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088755205", "display_name": "Brain mechanisms supporting the generalization of learned fear", "description": " 8. Project Narrative: Public Health The proposed research contributes to a greater understanding of mental health disorders marked by heightened expression of fear. These neuroimaging investigations attempt to uncover the brain mechanisms supporting the generalization of fear from a known fear-relevant stimulus to emotionally neutral stimuli that approximate the feared stimulus, either perceptually or semantically. A greater recognition of how generalization modulates the cognitive processes involved in fear expression will strengthen understanding of certain mental health disorders (e.g. specific phobias and posttraumatic stress disorder) and may lead to model systems important for the treatment and prevention of these disorders.", "funder_award_id": "1f31mh090682-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 30856.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F31", "start_date": "2010-11-16", "end_date": "2013-11-15", "start_year": 2010, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8060105", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOSEPH EDWARD", "family_name": "DUNSMOOR", "orcid": null, "role_start": null, "affiliation": {"name": "DUKE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088757073", "display_name": "A FAST & HIGH CAPACITY ELECTROMAGNETIC SOLUTION FOR HIGH FREQUENCY MIXED SIGNAL IC DESIGN", "description": "A FAST & HIGH CAPACITY ELECTROMAGNETIC SOLUTION FOR HIGH FREQUENCY MIXED SIGNAL IC DESIGN", "funder_award_id": "N000140610716", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 547219.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "BASIC AND APPLIED SCIENTIFIC RESEARCH", "start_date": "2012-03-21", "end_date": "2012-03-21", "start_year": 2012, "end_year": 2012, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_N000140610716_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088757797", "display_name": "CGI-58 Regulation of Triglyceride Metabolism and Inflammation", "description": null, "funder_award_id": "5f32dk084582-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 54854.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F32", "start_date": "2009-08-18", "end_date": "2011-08-17", "start_year": 2009, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7928076", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JENNA", "family_name": "BETTERS", "orcid": null, "role_start": null, "affiliation": {"name": "WAKE FOREST UNIVERSITY HEALTH SCIENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088758946", "display_name": "STATE OF THE SCIENCE AND PRACTICE PRECONFERENCE SESSION", "description": null, "funder_award_id": "5r13ca089535-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 10000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R13", "start_date": "2000-09-01", "end_date": "2005-08-31", "start_year": 2000, "end_year": 2005, "landing_page_url": "https://reporter.nih.gov/project-details/6522914", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "AUDREY E", "family_name": "NELSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF NEBRASKA MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088759102", "display_name": "Age-related hearing loss: Health services utilization and outcomes", "description": "PUBLIC HEALTH RELEVANCE: Hearing loss is among the most common chronic conditions of aging, but only a small percentage of older adults access the hearing health care system for diagnosis and treatment. These findings, and the growing population of older adults, call attention to hearing loss as a public health problem and emphasize the critical need for evidence of the impact of hearing loss on utilization of the healthcare system and health outcomes. Direct and indirect effects of age-related hearing loss, such as breakdowns in communication between older patients and their providers, may lead to exacerbation of other chronic health conditions, adversely affecting access to care, which may increase medication non-adherence, hospitalizations, emergency room visits, healthcare costs, and mortality. ", "funder_award_id": "1r21dc014031-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 261625.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2014-06-01", "end_date": "2016-05-31", "start_year": 2014, "end_year": 2016, "landing_page_url": "https://reporter.nih.gov/project-details/8750157", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANN-CATHERIN NORDBO", "family_name": "SIMPSON", "orcid": null, "role_start": null, "affiliation": {"name": "MEDICAL UNIVERSITY OF SOUTH CAROLINA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088759757", "display_name": "Les réactions appétitives en relation avec l'agression : Une investigation du rôle des bases neurocognitives et sensorimotrices de l'hostilité et du dégoût", "description": "Titre: Les réactions appétitives en relation avec l'agressivité : Une investigation du rôle des bases neurocognitives et sensorimotrices de l'hostilité et du dégoût\n\nCe projet de recherche vise à approfondir notre compréhension des facteurs qui contribuent à la perpétration de la violence et à l'agressivité appétitive - une forme biologique de comportement agressif qui est de nature hédonique (plaisante) et qui se manifeste par l'observation ou par des actes de violence. Plus précisément, les études proposées dans ce projet porteront sur les processus cognitifs et sensorimoteurs qui sont associés au dégoût et aux émotions hostiles dans le cerveau humain normal/intact au niveau fonctionnel par électroencéphalographie (EEG), physiologique (procédure d’induction de dégoût) et comportemental (tâches d’inhibition, décision lexicale). Ces études nous permettront de vérifier si les indicateurs implicites du dégoût activent des concepts hostiles qui reflètent la déshumanisation d’autrui (les attributions d'infériorité ou de caractéristiques rappelant la nature animale de l'humain dans une autre personne) et détermineront si cette relation contribue aux associations récompenses-agression. \n\nLes comportements agressifs causent des séquelles et traumatismes psychologiques et physiques durables à nombreuses victimes, avec des conséquences humaines et économiques élevées pour la santé publique et la société. Actuellement, un des grands obstacles à la recherche sur l'agressivité chez les sujets humains tiennent au fait que les motivations qui sous-tendent les comportements agressifs et appétitifs se basent fortement sur des mesures explicites (c'est-à-dire, l'auto-évaluation) et il est donc difficile de relier ces processus cognitifs aux comportements observés. En identifiant les mécanismes neurocognitifs et physiologiques qui sont directement impliqués dans les émotions hostiles liées à des biais cognitifs, ce projet contribue à une meilleure compréhension des facteurs qui maintiennent ces comportements. De plus, on espère que ces nouvelles découvertes contribueront à de meilleures stratégies d'intervention pour la gestion de l'agressivité et la réduction de la violence.", "funder_award_id": "292790", "funder": {"id": "https://openalex.org/F4320331165", "display_name": "Fonds de recherche du Québec", "doi": "10.13039/501100020951"}, "amount": 35000.0, "currency": "CAD", "funding_type": "award", "funder_scheme": null, "start_date": "2020-05-01", "end_date": "2022-04-30", "start_year": 2020, "end_year": 2022, "landing_page_url": "https://repertoire.frq.gouv.qc.ca/offres/detailOffres.do?methode=consulter&demId=292790", "doi": "https://doi.org/10.69777/292790", "provenance": "crossref_work", "lead_investigator": {"given_name": "Joyce", "family_name": "Quansah", "orcid": null, "role_start": "2020-05-01", "affiliation": {"name": "Université de Montréal", "country": null, "ids": [{"id": "https://ror.org/0161xgx34", "type": "ROR", "asserted_by": "publisher"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088760801", "display_name": "Personal and Relational Self-Expansion as Predictors of Relationship Satisfaction in Long-Distance Couples", "description": null, "funder_award_id": "65199", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 17500.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "Joseph-Armand Bombardier Canada Graduate Scholarships - Master's", "start_date": "2019-04-01", "end_date": null, "start_year": 2019, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Lasanen, Brittany D.", "orcid": null, "role_start": null, "affiliation": {"name": "The University of British Columbia", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088762405", "display_name": "Creation and utilization of perpendicularly spin-polarized electronic currents using perpendicularly magnetized spin-filtering tunnel barriers", "description": "本研究は，垂直磁化型の「トンネルスピンフィルター効果」を室温付近で高効率に実現し，薄膜の膜面に垂直な方向のスピンをもつ電子流の生成ができる新しい素子を創生することを目的とする。このような素子の開発は，垂直磁化型への展開が進められている最新のスピントロニクスにおいて重要な要素になると期待される。高効率なフィルターの実現に成功したのちは，垂直スピン電子注入による反強磁性体の磁気異方性制御など，新しいスピン分極電子源としての活用を図っていく。", "funder_award_id": "25K07833", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2025-04-01", "end_date": "2028-03-31", "start_year": 2025, "end_year": 2028, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25K07833/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "攻", "family_name": "壬生", "orcid": null, "role_start": null, "affiliation": {"name": "Nagoya Institute of Technology", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000040222327", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088763211", "display_name": "Control of Trabecular Meshwork Cytoskeleton", "description": " Glaucoma is the second most common cause of blindness in the U.S. and the most common cause of blindness among African-Americans. Attempts to understand the cause(s) of this disease have been hampered by the lack of well defined cell culture systems. The goal of this project is to identify the signaling pathway(s) activated during steroid induced glaucoma (SIG) so we identify potential therapeutic targets to reduce SIG. ", "funder_award_id": "2r01ey017006-06", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 376250.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2006-09-15", "end_date": "2014-03-31", "start_year": 2006, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8183518", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DONNA M", "family_name": "PETERS", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WISCONSIN-MADISON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088772656", "display_name": "The impact of funding incentives on knowledge production, research practices and utilization in population and public health", "description": "It is widely accepted that the major determinants of human health lie outside of the provision of health services. Social, cultural, environmental, psychological and behavioural factors interact with human biology to influence patterns of health and illness across populations. Complex public health problems, such as emerging infectious diseases and persistent health inequalities, require new approaches to conceptualizing and studying interactions between determinants of health . To facilitate the production of knowledge that examines these interactions from a variety of disciplinary and methodological approaches, and to increase the uptake of knowledge into policy and practice, health research funding bodies have developed incentives for innovative appraoches to research. Incentives often seek to increase interdisciplinary research, the use of diverse methods and collaboration between researchers and decision-makers throughout the knowledge production and dissemination processes. The main objective of this study is to understand how funding incentives impact both the production and utilization of determinants of health knowledge. Using a comparative case-study methodology, case studies will be conducted to examine the types of research funded by two to four Canadian health funding bodies (e.g. CIHR, SSHRC, Health Canada). A document analysis will be undertaken to classify studies according to variables such as methodology, use of theory, interdisciplinary collaboration and researcher-decision-maker engagement. Interviews will then be held with investigators from a sample of funded studies to explore how funding requirements influenced knowledge production, research practices and knowledge uptake. This study will contribute to our understanding of how to facilitate the production and utilization of knowledge that is needed to address new and persistent public health challenges in today's complex, global and technologically advanced world.", "funder_award_id": "76869_1", "funder": {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "doi": "10.13039/501100000024"}, "amount": 66000.0, "currency": "CAD", "funding_type": "fellowship", "funder_scheme": "CIHR Doctoral Research Award", "start_date": "2005-09-01", "end_date": "2008-08-31", "start_year": 2005, "end_year": 2008, "landing_page_url": "https://open.canada.ca/data/en/dataset/49edb1d7-5cb4-4fa7-897c-515d1aad5da3", "doi": null, "provenance": "cihr_opendata", "lead_investigator": {"given_name": "Wendy", "family_name": "Mcguire", "orcid": null, "role_start": "2005-09-01", "affiliation": {"name": "University of Toronto", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088772682", "display_name": "Maillard Reactions and Oxidation in Cataractogenesis", "description": null, "funder_award_id": "5r01ey009912-15", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 344149.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-09-01", "end_date": "2013-03-31", "start_year": 1994, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7796662", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RAM H", "family_name": "NAGARAJ", "orcid": null, "role_start": null, "affiliation": {"name": "CASE WESTERN RESERVE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088772747", "display_name": "PREVENTION OF TRIPLE-NEGATIVE BREAST CANCER BY NATURAL COMPOUNDS", "description": "PREVENTION OF TRIPLE-NEGATIVE BREAST CANCER BY NATURAL COMPOUNDS", "funder_award_id": "W81XWH1810032", "funder": {"id": "https://openalex.org/F4320306078", "display_name": "U.S. Department of Defense", "doi": "10.13039/100000005"}, "amount": 416907.36, "currency": "USD", "funding_type": "grant", "funder_scheme": "MILITARY MEDICAL RESEARCH AND DEVELOPMENT", "start_date": "2018-03-01", "end_date": "2021-02-28", "start_year": 2018, "end_year": 2021, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_W81XWH1810032_097/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088772752", "display_name": "SHF:Small:Performance Portable Parallel Programming on Extremely Heterogeneous Systems", "description": "The computers that are deployed today are increasingly complex as their designers strive to increase the speed with which computations are performed, while simultaneously maintaining or even reducing their power consumption. Many of them include energy-efficient accelerator devices. Adapting existing application programs so that they can execute well on new computer systems where such devices are configured is a labor-intensive and error-prone activity that requires significant expertise. Moreover, unless portable standards are used, different versions of a program may need to be created for different hardware. The effort required to do so may delay, or even prevent, many codes from fully exploiting new systems. This project will learn how to effectively utilize Machine Learning methods to help automate the adaptation process. Specifically, it will learn how to modify applications that already run on multicore platforms so that they can effectively exploit accelerator devices. At the same time, it will study and develop best practices with respect to utilizing Machine Learning in the context of improving the performance of applications.\r\n\r\nThis project will study and develop Machine Learning (ML)-based strategies and techniques to identify and extract code regions in technical applications that are suitable for mapping to the devices configured on a heterogeneous architecture. It will moreover develop the runtime technology needed to manage the execution of the resulting code. To accomplish this, the project will focus on application codes that have been parallelized to exploit multiple processing cores using the widely adopted, portable industry standard OpenMP and will use and extend features of the most recent OpenMP specification to express the device code and data mappings in a manner that is portable and permits subsequent manual optimization. The embedding of key choices in the code will aid performance portability. A key element of this research is the study of state-of-the-art ML methods, including classical ML and Deep-Learning techniques, with respect to their suitability for enhancing compilers and tools. An exploration of their relative merits for use in the compiler includes how to represent a compiler problem as a regression or classification problem. Research will also study approaches to code representation and the generation of sufficient data to train quality ML models. A set of benchmarks and mini-apps will be used to guide and evaluate the research. The project will participate in the work of the OpenMP Language Committee, will make practical results available via the open source LLVM infrastructure, will contribute to teaching and training materials, and will use this effort to enrich an ongoing collaboration with an HBCU.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "2113996", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 500000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2021-09-01", "end_date": "2026-08-31", "start_year": 2021, "end_year": 2026, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=2113996", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Barbara", "family_name": "Chapman", "orcid": null, "role_start": null, "affiliation": {"name": "SUNY at Stony Brook", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088773386", "display_name": "Comprehensive analysis of optical properties in the body surface of gelatinous zoolankton and their evolutionary and diversification processes", "description": "ゼラチン質プランクトンの多くは体を透明にすることで視覚捕食者に対して自身を隠蔽している。加えて、我々の研究により体の表面に特殊な構造をもつことで体の輪郭をぼやけさせる種も存在することが、系統の異なるいくつかの分類群で明らかになってきた。しかし、多くの種で、外皮の表面微細構造とその光学的特性あるいは適応意義については不明なままである。本研究は、ゼラチン質プランクトン外皮の微細構造、物性、光学特性を網羅的に明らかにし、外皮の形態・機能の類型化を行う。また、モデル検証を通して、それらの適応意義について明らかにする。さらに、ゼラチン質プランクトン外皮構造の進化・多様化の過程について解明する。", "funder_award_id": "23K26991", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 14690000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (B)", "start_date": "2024-04-01", "end_date": "2028-03-31", "start_year": 2024, "end_year": 2028, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23K26991/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "淳", "family_name": "西川", "orcid": null, "role_start": null, "affiliation": {"name": "Tokai University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010282732", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088776091", "display_name": "Genome instability induced by homologous recombination", "description": "Project Narrative Homologous recombination is a pivotal tumor suppressor pathway by maintaining genomic stability and is critical in repairing DNA lesions that are induced by ionizing radiation and other common modalities of DNA damaged-based anti-cancer therapy. Homologous recombination also reshapes genomes during meiosis, evolution, and ontogenic development affecting fertility, speciation, and human disease, especially cancer. The proposed project will lead to an improved mechanistic understanding of this critical DNA repair pathway and its contributions to remodel genomes.", "funder_award_id": "5r01gm137751-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 314000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2020-08-18", "end_date": "2025-07-31", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10670239", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "WOLF-DIETRICH", "family_name": "HEYER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA AT DAVIS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408877696", "display_name": "血清コレステロール値の差異に影響を与える因子に関する研究(食事因子を中心に)", "description": "Principal Investigator：片寄 眞木子, Project Period (FY)：1985, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：家政学", "funder_award_id": "60580083", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1500000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": "1985-04-01", "end_date": "1985-03-31", "start_year": 1985, "end_year": 1985, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60580083/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088777197", "display_name": "組合せ理論における極値的問題の確率的証明手法、及びそのアルゴリズム的側面の研究", "description": "ランダムグラフ上のラムゼ-理論を主に研究した。この分野に多いに貢献したB.Bollobas著Random Graphs(1985)は、ランダムグラフ上でのラムゼ-理論にはほとんど触れていない。が、最近の研究によってこの著書もすでに古くなった感があり、ラムゼ-理論の発展と確率的手法,ランダムグラフの研究の進展とともに,近年、ランダムグラフ上でのラムゼ-理論が技術的に可能になってきた。一方で、辺着色されたグラフの全頂点を単色の木で被覆する研究は強く注目をあびているものの古典的ラムゼ-理論の例にもれず,もっとも単純な完全グラフ上においてしかなされていない。今回は,これらの状況をふまえ、この単色木被覆の研究はランダムグラフを融合させる試みを行なった。それによると、2着色の場合、完全グラフにおける(単色木による)被覆数は1、辺を一本除去したグラフは2まであがるが、その後、辺をランダムに除去し続けた場合、かなり辺が減ってしまった場合においても2のままでありつづけ,ある段階で突然無限にとんでしまう。(例えば、ほぼ全てのグラフの被覆数が2である。)また、着色数が3以上の場合、2着色の場合ほど突然ではなく、被覆数がもっと早い段階から増加していることがわかった。完全グラフの場合,2着色と3着色以上でも性質が似ているのに対し、ランダムグラフの場合でははっきりとした差が確認された。この意味でも興味深い。ランダムグラフ上で議論可能なラムゼ-的性質はまだあまり多くはないが、なかでも本研究における単色木被覆の研究は新たにわかった基礎的なラムゼ-的性質であり,本研究が、古典的な完全グラフ上での研究の単なる拡張ではなく、ランダムグラフとラムゼ-の融合による独特の課題であるという点でも意義が認められる。", "funder_award_id": "07740147", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1200000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1995-04-01", "end_date": "1995-03-31", "start_year": 1995, "end_year": 1995, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07740147/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "嘉康", "family_name": "石上", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Electro-Communications", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050262374", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088778599", "display_name": "NOVEL EFFECTORS OF NEUTROPHIL PHOSPHOLIPASE A2", "description": null, "funder_award_id": "1r01dk042615-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1991-08-01", "end_date": "1995-07-31", "start_year": 1991, "end_year": 1995, "landing_page_url": "https://reporter.nih.gov/project-details/3243760", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MIRIAM D", "family_name": "ROSENTHAL", "orcid": null, "role_start": null, "affiliation": {"name": "EASTERN VIRGINIA MEDICAL SCHOOL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088779501", "display_name": "Rural General Practitioners in Australia: Costs, Returns and Relative Work Value of Rural Compared with Urban Private General Practitioners", "description": "Aims:\r\n* To conduct a rurally focused study of GPs in Australia, to address rural GPs' concerns about remuneration, and consumers' concerns about access to rural GPs.\r\n* To examine costs, prices, returns and work value differentials between rural and urban GPs.\r\nSignificance:\r\n* The first systematic economic evaluation of rural GP remuneration and work value in Australia.\r\n* Reflection of the profession's geographical heterogeneity in policy recommendations.\r\nExpected outcomes:\r\n* Improved measurements of effects of geographcial location on costs, remuneration and relative work value of rural GPs.\r\n* Improved understanding of effects of differential rates of GP bulk-billing.", "funder_award_id": "LP0219348", "funder": {"id": "https://openalex.org/F4320334704", "display_name": "Australian Research Council", "doi": "10.13039/501100000923"}, "amount": 82988.0, "currency": "AUD", "funding_type": "research", "funder_scheme": "Linkage Projects", "start_date": "2002-01-01", "end_date": "2006-12-31", "start_year": 2002, "end_year": 2006, "landing_page_url": "https://dataportal.arc.gov.au/RGS/Web/Grants/LP0219348", "doi": null, "provenance": "arc", "lead_investigator": {"given_name": "Susan", "family_name": "Day", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Melbourne", "country": "Australia", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088784122", "display_name": "Enhancement of the Paleontology Research Collection at the University of Montana", "description": "An award has been made to the University of Montana under the direction of Dr. George D. Stanley to acquire new metal cabinets for the collection of Bear Gulch fossil biota of central Montana. This collection contains important fossils of vertebrates, invertebrates, plants and algae that is unique in its composition and in the retention of original colors by many of the fossils. The diversity of materials adds to our understanding of ancient climates on the planet. The project will replace older oak cabinets, which are known to produce acid vapors that cause deterioration of the fossil rock material and destroy their scientific value. The collection will be re-housed in cabinets in a mobile compactor system that will improve the physical accessibility of the collection for researchers and students. The specimens will be catalogued, photographed, and the images and associated data will be made available online and through the web site called PaleoPortal. Students will be employed in the project and will be trained in the practice of paleontological curation.", "funder_award_id": "0749683", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 376895.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2008-03-15", "end_date": "2013-06-30", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749683", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "George", "family_name": "Stanley", "orcid": null, "role_start": null, "affiliation": {"name": "University of Montana", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088785629", "display_name": "LOW BIRTH WEIGHT AND SUCCESSIVE PREGNANCY OUTCOME", "description": null, "funder_award_id": "n01hd002916-000", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "1990-08-01", "end_date": "1993-10-31", "start_year": 1990, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/2314499", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN E", "family_name": "BROCKERT", "orcid": null, "role_start": null, "affiliation": {"name": "UTAH STATE DEPARTMENT OF HEALTH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088786406", "display_name": "A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies", "description": "PROJECT NARRATIVE Congenital genetic abnormalities are a leading cause of childhood mortality and morbidity. While routine newborn screening (NBS) has dramatically improved health outcomes, many congenital disorders such as Duchenne muscular dystrophy (DMD) and other congenital muscular dystrophies (CMD) are not currently detected by routine NBS. The goal of this Fast Track SBIR project is to develop a complete testing solution for efficient newborn screening of DMD and CMDs from dried blood spot (DBS) specimens. The system will consist of automated, low volume biochemical assays for creatine kinase (CK) enzyme activity and CK isoform expression (CK-MM and CK-MB) followed by 2nd-tier targeted next generation sequencing (tNGS) in CK (+) individuals to detect common causal gene variants associated with DMD and CMDs.", "funder_award_id": "4r44hd095713-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 710423.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R44", "start_date": "2019-05-08", "end_date": "2021-04-30", "start_year": 2019, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9799120", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ARINDAM", "family_name": "BHATTACHARJEE", "orcid": null, "role_start": null, "affiliation": {"name": "BAEBIES, INC.", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408878661", "display_name": "Sprance-Unesp and TTU collaboration in high-energy physics in the compact muon solenoid experiment at the Large Hadron Collider", "description": "Texas Tech University (TTU) and the São Paulo Research and Analysis Center (SPRACE-UNESP) groups are active members of the CMS Collaboration at CERN, Geneva, Switzerland. Both groups lead and participate in the analysis data in the field of physics beyond (AU)", "funder_award_id": "15/50009-0", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "grant", "funder_scheme": "Auxílio à Pesquisa - Regular", "start_date": "2015-07-01", "end_date": "2017-06-30", "start_year": 2015, "end_year": 2017, "landing_page_url": "https://bv.fapesp.br/en/auxilios/15-50009-0/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Sergio", "family_name": "Ferraz Novaes", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade Estadual Paulista (UNESP). Campus de São Paulo. Núcleo de Computação Científica (NCC)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088789609", "display_name": "Anxiolytic Effects and Abuse of BZ Receptor Ligands", "description": "Valium and related drugs, referred to as “benzodiazepines” are prescribed widely for the treatment of anxiety disorders, one of the most common psychiatric disorders in the U.S. Benzodiazepines are considered to be among the safest prescription drugs in modern medicine, but they unfortunately are also drugs of abuse. The overall goal of this application is to uncover mechanisms that control the beneficial effects as well as the abuse of benzodiazepines, with the hope of developing drugs for treating BZ addiction.", "funder_award_id": "5r01da011792-23", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 385116.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1998-06-15", "end_date": "2025-04-30", "start_year": 1998, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10212994", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES K", "family_name": "ROWLETT", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MISSISSIPPI MED CTR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088790847", "display_name": "Enhancing Scientific Inquiry in Clinical Neurosciences Through Methodology Traini", "description": "PUBLIC HEALTH RELEVANCE: We propose a training course to enable young investigators to learn how to design the best early clinical trials to enable discovery of effectiv treatments. Our team is comprised of experts who collaborate within large, NIH funded research networks focused on neurological diseases. Our approach will enhance and maintain the pipeline of scientifically-sound clinical trials and promising young investigators in a way that promotes health by discovering important, effective new treatments.", "funder_award_id": "5r25ns088248-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 466189.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R25", "start_date": "2014-04-01", "end_date": "2019-03-31", "start_year": 2014, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/9233214", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHRISTOPHER S.", "family_name": "COFFEY", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MICHIGAN AT ANN ARBOR", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088791981", "display_name": "マレーシア・サラワク州における民族再編と地域構造変化", "description": "本研究では,マレーシア・サラワク州における現地調査を中心にデータ収集を行った。具体的には,マレーシア最大の河川ラジャン川の上流域において,人の移動を中心とする社会的な動きについての調査を行った。当該地域には,1960年代から70年代にかけて,インドネシア・カリマンタンから移住してきたクニャ人の集落が点在している。当時の移住の理由は,カリマンタン側における人口圧が高まり土地が相対的に不足したこと,砂糖や塩などの日常品購入の面でサラワクに居住する方が便利であったこと,そして,間接的ではあるが,1960年代後半のインドネシアとマレーシアの間の政治的緊張がこの地にも及んで,安定した生活を求めた人たちがサラワク側に流れたこと,である。しかし,こうした移住の波とは別の動きが1990年代半ばから顕著になった。それは、サラワクの木材伐採企業が,当該地位に木に伐採キャンプを開き,インドネシアからの非合法入国者を重要な労働力として使用し始めたことによる。インドネシアのクニャ人のサラワクでの非合法就労は,1950年代から行われていたことではあるが,1990年代に入ってその数は激増し,国境付近の地域社会に大きな変化をもたらした。注目すべきことは,こうした非合法入国者が,60年代以降に移住してきた集落をベースとして,ラジャン川最上流域での就労活動を展開しており,国境を越える新たな人的ネットワーク形成しているという点である。しかし,そうしたネットワークの形成は,サラワクの木材伐採企業の動きや両政府の雇用政策に大きく依存しており,クニャ人の就労の地域的・内容的な多様性は失われている。こうしたことから,越境移動と地域変化を見る場合に,従来の国境形成とエスニック・アイデンティティとの関係についての議論に加えて,政府の雇用政策や企業の動向が人的移動にもらたす影響をも視野に入れた考察を行う必要があると指摘できる。", "funder_award_id": "13780059", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Young Scientists (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13780059/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "亮次", "family_name": "祖田", "orcid": null, "role_start": null, "affiliation": {"name": "Hokkaido University(2002)Hiroshima University(2001)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030325138", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088795378", "display_name": "Design of New Enzyme Catalysts", "description": " Project Narrative During this grant period, we will develop and use the tools of computational chemistry to design novel enzymes. Our emphasis will be to demonstrate that we can do what has never been done before: design a functioning enzyme from scratch, starting with ideas about a catalytic site and ending with a fully functioning enzyme for a non-natural reaction. The initial target reactions will be of use in the synthesis of pharmaceutical targets and for the decomposition of a broad class of compounds utilized as pesticides and herbicides.", "funder_award_id": "5r01gm075962-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 303694.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-04-01", "end_date": "2013-02-28", "start_year": 2009, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7782699", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KENDALL N", "family_name": "HOUK", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA LOS ANGELES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088796391", "display_name": "Network Dysfunction and Neuromodulation following TBI", "description": "Narrative The proposed research is relevant to public health, because although memory dysfunction is a frequent and persistent symptom of traumatic brain injury (TBI), there are currently no effective treatments available for this persistent deficit. In addition, the neurophysiological basis of these deficits remains unknown, making rational treatment design difficult. The project is relevant to the NINDS mission because knowledge of why TBI induced memory disorders persist, and how neuromodulation alleviates them in animal models, will allow for clinical treatment development that will reduce the burden of these deficits.", "funder_award_id": "5r01ns101108-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 352188.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2017-04-01", "end_date": "2022-03-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9453047", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN ALLEN", "family_name": "WOLF", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088798327", "display_name": "Open Science Impact Pathways", "description": "PathOS aims to identify and quantify the Key Impact Pathways of Open Science relating to the research system and its interrelations with economic and societal actors. PathOS will enable a new understanding of OS impacts and their causal mechanisms through its workplan encompassing actions to synthesise and structure current evidence, development of new methods and tools for measuring impact, iterative pilot-testing via in-depth case studies, innovative dissemination and networking, and co-creation synthesis activities culminating in policy recommendations. This is pivotal in order to develop effective OS policy in the EU. It will do so by collecting concrete evidence of the causal effects of OS by studying the pathways of OS practices, from input to output, outcome and impact, including the consideration of enabling factors and key barriers. Impacts and pathways will be developed in particular in the three areas of science, society and economy. By investigating, measuring and comparing its costs and benefits together with its pathways, PathOS will (i) bring a better understanding of the implications of open science for science, economy and society, (ii) provide recommendations to policy makers and other actors in the RandI ecosystem as to how and to what extent open science should be promoted in a balanced way, and (iii) develop innovative tools and methods using a big data to augment traditional ones for studying the causal effects of open science. This will enable evidence-based Open Science policy prioritisation, maximum OS impact, and increased RandI capacity in EU research systems.", "funder_award_id": "101058728", "funder": {"id": "https://openalex.org/F4320338452", "display_name": "HORIZON EUROPE Reforming and enhancing the European Research and Innovation system", "doi": "10.13039/100018707"}, "amount": 1999990.0, "currency": "EUR", "funding_type": "grant", "funder_scheme": "HORIZON.4.2", "start_date": "2022-09-01", "end_date": null, "start_year": 2022, "end_year": null, "landing_page_url": "https://cordis.europa.eu/project/id/101058728", "doi": "https://doi.org/10.3030/101058728", "provenance": "crossref_work", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088803113", "display_name": "US - CH Nanoforum, Princeton, USA, with focus NanoBioSciences", "description": null, "funder_award_id": "64209", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 25000.0, "currency": "CHF", "funding_type": "research", "funder_scheme": "NRP 36 Nano Sciences", "start_date": "2000-12-01", "end_date": "2001-02-28", "start_year": 2000, "end_year": 2001, "landing_page_url": "https://data.snf.ch/grants/grant/64209", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Leuenberger,", "family_name": "Hans", "orcid": null, "role_start": null, "affiliation": {"name": "University of Basel – BS", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408880365", "display_name": "Mathematical Sciences: Percolative Models", "description": "9618128 Zhang The project concentrates on percolation theory, a mathematical theory used to describe transitions of physical systems. Percolation theory has a variety of applications to solid physics, biology, computer science, and geology. A percolation process typically depends on one or more parameters. A dramatic change in physical properties may occur as a critical parameter value is passed. The research will focus on the behavior of percolative models in the following three areas: percolation near, above and below the critical thresholds. In particular, the project will investigate mathematically rigorous exact solutions for the percolative models. The research makes use of probability theory (the moment estimations, the ergodic theory, correlation and martingale inequalities and stochastic ordering), graph theory (duality, the fractal dimension), combinatorics (partition lattices, distributive lattices), and function analysis (the real analyticity). The project will use these mathematical tools to advance our rigorous understanding of critical phenomena. The project concentrates on percolation, a mathematical model used to describe transitions of physical systems. Percolation theory has a variety of applications to solid physics, biology, computer science, and geology. A percolation process typically depends on one or more parameters. A dramatic change in physical properties may occur as a critical parameter value is passed. For example, suppose we immerse a large porous solid in a bucket water. Clearly, how water penetrates the solid depends on the size of the pores of the solid. A simple mathematical model of such a process is defined by taking the pores to be distributed in some regular manner, and to be open or closed with probabilities p or 1-p. There is a critical threshold, for the probability p at which the behavior changes abruptly. For values of p below the critical value the water penetration is only superficial and above it the penetration is arbitrarily deep. The specific behavior near the critical threshold is more complicated. One of the most challenging problems is to give a mathematical description of deep penetration near the critical threshold. The research will focus on three areas: the behaviors of percolation near the critical threshold, above the critical threshold and below the critical threshold. In particular, the project will investigate mathematically rigorous exact solutions for the percolation process. The research makes use of probability theory, graph theory, combinatorics and function analysis. The project will use these mathematical tools to advance our rigorous understanding of critical phenomena.", "funder_award_id": "9618128", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 61855.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "1997-07-15", "end_date": "2000-06-30", "start_year": 1997, "end_year": 2000, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=9618128", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Yu", "family_name": "Zhang", "orcid": null, "role_start": null, "affiliation": {"name": "University of Colorado at Colorado Springs", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088805542", "display_name": "Architecture Design Method for Multi-processor SoC", "description": "This research proposed a new exploration method for Multi-Processor SoC architecture and task assignment optimization method, and implemented these methods as prototype design tools. Experimental results show that the proposed method can find solutions that are same quality as the optimal solutions in short time", "funder_award_id": "20300017", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 19110000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (B)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20300017/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Masaharu", "family_name": "IMAI", "orcid": null, "role_start": null, "affiliation": {"name": "Osaka University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050126926", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408880564", "display_name": "Role of Oxidants & Angiogenesis in Kaposi's Sarcoma", "description": null, "funder_award_id": "5r01ca095901-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 285126.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2003-04-15", "end_date": "2010-03-31", "start_year": 2003, "end_year": 2010, "landing_page_url": "https://reporter.nih.gov/project-details/7192432", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SUSAN R", "family_name": "MALLERY", "orcid": null, "role_start": null, "affiliation": {"name": "OHIO STATE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088806260", "display_name": "EVOLUTION OF PRIMITIVE PLANETARY MATERIALS IN THE PROTOPLANETARY DISK: THROUGH A VARIETY OF IN SITU ANALYTICAL TECHNIQUES - WE WILL INVESTIGATE THE", "description": "EVOLUTION OF PRIMITIVE PLANETARY MATERIALS IN THE PROTOPLANETARY DISK: THROUGH A VARIETY OF IN SITU ANALYTICAL TECHNIQUES - WE WILL INVESTIGATE THE", "funder_award_id": "NNX09AD35G", "funder": {"id": "https://openalex.org/F4320306101", "display_name": "National Aeronautics and Space Administration", "doi": "10.13039/100000104"}, "amount": 49562.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "SCIENCE", "start_date": "2010-11-26", "end_date": "2010-11-26", "start_year": 2010, "end_year": 2010, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_NNX09AD35G_080/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088808848", "display_name": "Neuro-immune-metabolic interactions mediated by axon guidance cues", "description": "申請者はこれまでに神経ガイダンス因子であるセマフォリン分子群が免疫代謝を制御することを明らかにしている。さらに、セマフォリン分子群が骨髄内における神経-免疫-代謝連関に寄与することを示唆するデータを得ている。本研究においては、骨髄、脂肪組織をはじめとする各組織における神経-免疫-代謝連関へのセマフォリン分子群の寄与を検討することで、「臓器レベル、生体レベルでの神経-免疫-代謝連関」という独自の概念を確立すると同時に、神経-免疫-代謝連関の破綻により生じる疾患の診断及び治療の確立に繋がる成果を目指す。", "funder_award_id": "20K22900", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2860000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Research Activity Start-up", "start_date": "2020-09-11", "end_date": "2022-03-31", "start_year": 2020, "end_year": 2022, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K22900/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yoshimitsu", "family_name": "Nakanishi", "orcid": null, "role_start": null, "affiliation": {"name": "Osaka University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070882645", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40888101", "display_name": "The role of macroH2A variants in cancer and senescence", "description": "Decreases in one form of a protein called macroH2A, a factor involved in regulating the activity of many of our genes, occurs in a variety of cancers, including endometrial, lung, cervical, testicular, colon, and urinary bladder cancer. This proposal seeks to explore both the causes that lead to the decrease of this factor and the effect this change has on cancer cell growth and survival. Given the ability of macroH2A to collaborate with a therapeutic target for several cancers, PARP-1, our studies on the expression and function of macroH2A will have important implications for more targeted use of PARP inhibitors in cancer treatment.", "funder_award_id": "5r01ca155232-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 136610.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2012-05-04", "end_date": "2015-08-31", "start_year": 2012, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8825448", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MATTHEW J", "family_name": "GAMBLE", "orcid": null, "role_start": null, "affiliation": {"name": "ALBERT EINSTEIN COLLEGE OF MEDICINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088811459", "display_name": "Nanomedicine Center for Nucleoprotein Machines", "description": null, "funder_award_id": "5pn2ey018244-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 3224999.0, "currency": "USD", "funding_type": "program", "funder_scheme": "PN2", "start_date": "2006-09-30", "end_date": "2015-07-31", "start_year": 2006, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8321615", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GANG", "family_name": "BAO", "orcid": null, "role_start": null, "affiliation": {"name": "GEORGIA INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088814493", "display_name": "Nanoscience Foundries and Fine Analysis", "description": "We intend to study the feasibility of an European cluster of nanoscience facilities, which will consist of 3-6 Centres closely attached to a number of selected Large Scale Facilities located within Europe (synchrotron radiation sources, neutron scattering sources, high power lasers including free electron lasers and high performance computing, etc). This cluster of nanoscience facilities will enable users to conduct fine analysis experiments and modelling at the nanoscale by offering access to state-of-the-art synthesis, nanofabrication and analysis to a wide research community. Hence, by providing innovative cutting edge preparation and characterization technologies to European scientists, this delocalized institution will raise the standards of nanoscience experiments in the European Research Area and allow full exploitation of the affiliated Large Scale Facilities. The NFFA design study will develop the Emerging Proposals, named NANOSCIENCE, in synergy with the ESFRI roadmap 2006. NFFA is a structuring project for the ERA that requires to be started with support by the EC under FP7, in order to reach the maturity to be validated as a potential RI by ESFRI. The NFFA Centres for users will share a common technical platform for advanced nanofabrication and characterization of nanostructures, complemented by specialised methods for synthesis of materials, specific analysis, computational methods of simulation, according to a coordinated science plan. The NFFA design study will analyse the full spectrum of Research infrastructures relevant for nanoscience that are currently in operation OR in the preparatory phase of FP7.", "funder_award_id": "212348", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 1800000.0, "currency": "EUR", "funding_type": "research", "funder_scheme": "FP7 - CP", "start_date": "2008-06-01", "end_date": "2011-01-31", "start_year": 2008, "end_year": 2011, "landing_page_url": "https://cordis.europa.eu/project/id/212348", "doi": "", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "CONSIGLIO NAZIONALE DELLE RICERCHE", "country": "IT", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088815596", "display_name": "CYCLOPROPYL METABOLITES, ENZYMATIC INHIBITION/FORMATION", "description": null, "funder_award_id": "5r01gm040541-12", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 101673.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1989-04-01", "end_date": "2001-01-31", "start_year": 1989, "end_year": 2001, "landing_page_url": "https://reporter.nih.gov/project-details/6179612", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "HUNG-WEN", "family_name": "LIU", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF MINNESOTA TWIN CITIES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088815616", "display_name": "The Science of COVID-19 Vaccines", "description": "No summary - Aucun sommaire", "funder_award_id": "562750-2021", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 1000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "NSERC Student Ambassadors", "start_date": "2021-04-01", "end_date": "2022-03-31", "start_year": 2021, "end_year": 2021, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=562750-2021", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Ryan", "family_name": "Kisslinger", "orcid": null, "role_start": null, "affiliation": {"name": "University of Alberta", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088816517", "display_name": "Macrophage Expression of SPARC Contributes to Pressure-Overload Dependent Change in Collagen Content and Myocardial Stiffness", "description": "Relevance to Veterans Health Care: Strategies to improve treatments for chronic heart failure (CHF) is of significant value to our Veterans population. CHF has a designated Quality Enhancement Research Initiative (QUERI) in the VA system to address ways to improve cardiovascular healthcare for Veterans suffering from CHF. If we can more completely determine the cellular mechanisms that cause changes in functional capacity and substrate vulnerability, more effective and comprehensive patient care management programs can be developed to limit the effects of aging and other co-morbidities, such as hypertension, on heart structure and function. Elucidation of cellular mechanisms that govern increases in cardiac collagen has the potential to improve strategies in this regard. These issues are especially important in our Veterans who are older, have a high incidence of hypertension, and have a disproportionately greater level of age-dependent functional limitations.", "funder_award_id": "5i01cx001608-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "I01", "start_date": "2017-10-01", "end_date": "2021-09-30", "start_year": 2017, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9814120", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "AMY D", "family_name": "BRADSHAW", "orcid": null, "role_start": null, "affiliation": {"name": "RALPH H JOHNSON VA MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088817863", "display_name": "Collaborative Research: Correlations in neural dynamics and coding", "description": "Multi-electrode recording technology and voltage sensitive dyes allow researchers to probe the structure of correlated, stimulus-driven neural activity in groups of cells. However, the diversity of brain areas and stimuli make a complete sampling of these patterns and their effects impossible. Furthermore, the evidence of correlations in stimulus response is strong, yet its role in neural coding difficult to intuit. Therefore, a combined, predictive theory of correlation formation and impact is required. This challenge is approached in three stages. First, a general mathematical theory is developed that relates input correlations of a stochastic forcing to the output correlations of resultant spike trains. The underlying tools will be linear response, population density, and Monte-Carlo methods for the nonlinear stochastic differential equations of spiking neural circuits. Next, this theory is applied to a variety of neural models to quantify how neuron biophysics, morphology, and coupling influence input-output correlation transfer. Finally, information-theoretic analyses are performed to estimate the impact of spike train correlations on the encoding and propagation of sensory inputs in representative neural circuits. Throughout the project, the investigators will work with experimental collaborators to refine and test these predictions. \r\n\r\nUnderstanding the mechanisms by which the nervous system represents and processes information is a fundamental challenge for mathematical biology. It has long been known that information is represented by the intensity of individual neurons' responses. However, new multi-neuron recording and brain imaging techniques are revealing that the information carried by neural tissue is much more (or much less) than the summed contributions of individual neurons. In other terms, the cooperative, correlated features of neural responses can be essential. This poses a pair of fundamental, but unresolved theoretical questions: What are the basic mechanisms by which correlated activity is generated and propagated through layers of neural tissue? What are the consequences for information processing in neuronal networks? The answers will, in stages, make predictions for ongoing neurobiological experiments. For instance, understanding the relation between correlations and neural coding stands to impact the design of neural prosthetics, which code motor and sensory signals via cortical, retinal, thalamic, and cochlear implants. From an alternative perspective, many neurological disorders, such as epilepsy and Parkinson's disease, involve excessive correlation in neural tissue--describing the genesis of correlations and its negative impact on neural coding will aid in designing appropriate treatments that ultimately reduce correlation in the nervous system. Along the way, graduate students involved in this research will receive training in a highly interdisciplinary field, and will gain a broad perspective on mathematical neuroscience through regular visits between three research groups in different regions of the United States. The active involvement of the investigators in undergraduate research and course development will provide an opportunity to translate the questions addressed here into compelling educational topics on the cooperative activity in neural networks that will be accessible to a wide audience.", "funder_award_id": "0817649", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 151134.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2008-08-15", "end_date": "2012-07-31", "start_year": 2008, "end_year": 2012, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0817649", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Kresimir", "family_name": "Josic", "orcid": null, "role_start": null, "affiliation": {"name": "University of Houston", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088821587", "display_name": "XI Encontro Nacional de Conforto no Ambiente Construído (XI ENCAC) e VII Encontro Latino Americano de Conforto no Ambiente Construído (VII ELACAC)", "description": null, "funder_award_id": "11/14003-6", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Brasil", "start_date": "2011-08-17", "end_date": "2011-08-19", "start_year": 2011, "end_year": 2011, "landing_page_url": "https://bv.fapesp.br/en/auxilios/11-14003-6/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Claudia", "family_name": "Cotrim Pezzuto", "orcid": null, "role_start": null, "affiliation": {"name": "Pontifícia Universidade Católica de Campinas (PUC-CAMP). Faculdade de Engenharia Civil", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088821737", "display_name": "Cys-LT signaling in proliferation, cytokine production and PGD2 generation of MCs", "description": " This proposal seeks to determine how a common lipid mediator leukotriene E4 can regulate the activation of mast cells, an important cells mediating the inflammatory responses in response to allergens and infectious agents. Studying this could help us in better understanding and treatment strategies for asthma and other allergies.", "funder_award_id": "5r00hl098953-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 248847.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R00", "start_date": "2011-09-20", "end_date": "2014-03-31", "start_year": 2011, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8334594", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SAILAJA", "family_name": "PARUCHURI", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF AKRON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088822011", "display_name": "IL-6シグナルに潜むネガティブフィードバック機構の炎症性骨・歯根吸収への応用", "description": "IL-6はサイトカインの一種であり,破骨細胞の分化に深く関与している。様々なシグナル伝達経路にはネガティブフィードバック機構が存在することが知られている。IL-6においても破骨細胞の分化を抑制する機構が潜んでいる可能性があると申請者らは考えている。そこで,IL-6のネガティブフィードバック機構をシグナル伝達経路の観点から明らかにすることを本研究の目的とした。平成18年度の研究目標は,破骨細胞前駆体におけるIL-6の効果について明らかにすることである。マウス骨髄から採取した破骨細胞前駆体をM-CSF+RANKLもしくはM-CSF+RANKL+IL-6の条件下で培養し,TRAP染色にて破骨細胞を染色し破骨細胞数を計測した。その結果,IL-6は破骨細胞への分化を強く抑制すること(1/4に減少)が明らかとなった。さらに,破骨細胞の分化段階について詳細に解析するために,破骨細胞分化マーカーの発現について検索を行った。TRAPおよびカルシトニンレセプターそしてカテプシンKといった初期および後期破骨細胞分化マーカーの発現は,いずれもIL-6を加えることによりほぼ完全に抑制された(TRAP:71%,カルシトニンレセプター:99%,カテプシンK:99%抑制)。さらにRANK下流のシグナル伝達分子NFkBおよびJNKそしてp38に対するIL-6の影響についての解析を行った。RAMKLがRANKに結合すると,これら3つのシグナル伝達経路が活性化されることが報告されているが,IL-6の刺激を加えるとp38の活性化には影響がなかったがIkBの分解およびJNKの活性化が抑制されることが明らかとなった。以上の解析結果から,IL-6は,破骨細胞前駆体においてRANKシグナルの活性化を抑制し,破骨細胞への分化を抑制することが明らかとなった。平成18年度の研究目標に対して十分な研究成果が得られたと考えている。", "funder_award_id": "18592086", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 3790000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18592086/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "祥作", "family_name": "伊藤", "orcid": null, "role_start": null, "affiliation": {"name": "Osaka University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000090360495", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088822905", "display_name": "Les cultures de traduction transnationales sous la reine Henriette Marie et le roi Charles Ier d'Angleterre (1625-1649): les traductions manuscrites et imprimées en Angleterre prémoderne", "description": "L’union du roi anglican Charles Ier avec la princesse catholique française Henriette Marie en 1625a contribué à diviser l’Angleterre en factions religieuses. L’intérêt de la reine pour la littérature dévotionnelle catholique et la culture française a forgé le marché anglais de la littérature traduite. D’autre part, les traducteurs ont su tirer parti du mécénat de la reine pour contourner la censure de la Star Chamber et rendre des textes catholiques interdits disponibles aux lecteurs anglais. Les fonctions des traductions imprimées et la dissémination de la littérature étrangère en Angleterre prémoderne ont fait l’objet de nombreuses études à la suite de la création de catalogues de traductions imprimées tels le « Renaissance Cultural Crossroads » et le « Cultural Crosscurrents in Stuart and Commonwealth Britain ». Il est tentant de croire que la révolution déclenchée par l’invention de la presse à imprimer a mené à l’abandon de l’écriture comme mode de dissémination de la littérature, mais de nombreuses études ont prouvé la coexistence des manuscrits et des livres imprimés en Europe à la Renaissance. Ce projet a pour but de mettre en lumière l’impact des traductions manuscrites et imprimées dans le mouvement transnational de la littérature entre l’Angleterre prémoderne et la France. Pour ce faire, je créerai une base de données en libre accès dans laquelle je recenserai les traductions manuscrites produites pendant le règne de Charles Ier (1625-1649) qui sont conservées en ligne et dans des archives de livres rares au Canada et à l’étranger. En analysant ces textes conjointement avec des données sur les traductions imprimées à la même période, je mettrai en valeur la contribution des pratiques manuscrites à une époque où la culture de l’imprimé semblait dominer le marché du livre européen. Je serai en mesure de fournir des précisions sur les divers rôles des agents qui participaient à la production et à la circulation des livres traduits (mécènes, auteurs, traducteurs, censeurs, imprimeurs, marchands de livres, lecteurs), leurs pratiques, et les réseaux dans lesquels ils opéraient. Ma base de données et mes publications contribueront aux recherches visant à améliorer notre compréhension des échanges textuels transnationaux en Europe prémoderne.", "funder_award_id": "285173", "funder": {"id": "https://openalex.org/F4320331165", "display_name": "Fonds de recherche du Québec", "doi": "10.13039/501100020951"}, "amount": 90000.0, "currency": "CAD", "funding_type": "award", "funder_scheme": null, "start_date": "2020-05-15", "end_date": "2022-05-14", "start_year": 2020, "end_year": 2022, "landing_page_url": "https://repertoire.frq.gouv.qc.ca/offres/detailOffres.do?methode=consulter&demId=285173", "doi": "https://doi.org/10.69777/285173", "provenance": "crossref_work", "lead_investigator": {"given_name": "Marie-France", "family_name": "Guénette", "orcid": "https://orcid.org/0000-0003-2822-4041", "role_start": "2020-05-15", "affiliation": {"name": "Université de Montréal", "country": null, "ids": [{"id": "https://ror.org/0161xgx34", "type": "ROR", "asserted_by": "publisher"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088823148", "display_name": "MACHINE LEARNING AND PARALLEL COMPUTER TECHNOLOGY", "description": null, "funder_award_id": "7p41lm005205-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "program", "funder_scheme": "P41", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3859802", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "RANDALL", "family_name": "SMITH", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088823394", "display_name": "OPTIMIZING AND PERSONALIZING INTERVENTIONS FOR SCHIZOPHRENIA ACROSS THE LIFESPAN (OPAL)", "description": "PROJECT NARRATIVE - OVERALL The target population for this ALACRITY Center is individuals affected by schizophrenia or related disorders, who are at risk for poor outcomes including disability, premature mortality, homelessness, and incarceration. However, many effective treatments for schizophrenia have been developed. The goal of this Center is to develop and test ways to improve access to and engagement with personalized interventions that are effective.", "funder_award_id": "5p50mh115843-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1273862.0, "currency": "USD", "funding_type": "program", "funder_scheme": "P50", "start_date": "2018-04-01", "end_date": "2021-12-31", "start_year": 2018, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9841450", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "THOMAS SCOTT", "family_name": "STROUP", "orcid": null, "role_start": null, "affiliation": {"name": "NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088823426", "display_name": "EVALUATION OF LOADS AND STRUCTURAL RESISTANCES IN THE LIMIT STATE DESIGN", "description": "In the development of practical aspects of the limit state design, quite a few problems for the load and the structural resistance are to be solved. In this study, (1) the evaluation of limit state for members in steel structure, (2) the dynamic response for both the earthquake and the strong wind, (3) the load combination model are focused to be investigated.The limit state in terms of local buckling and Euler buckling is evaluated with aids of existing experimental results, which are also rearranged in a form of data base with slenderness ratio and width-thickness ratio as major parameters. Such efforts should be continued further for effective uses of the limit state design.Wing response studies are conducted by establishing an analytical model for the sway-torsional vibration. Simulated wing load fluctuations with a specified correlation are used for numerical response analyzes. Seismic response studies consist of two parts, one is the analysis of recorded responses of scaled structure to reveal the collapse process of steel structure and the other is the statistical evaluation of structural behavior for high rise buildings to compute the seismic safety in terms of the second moment reliability.The load combination model is one of important parts of the limit state design. Level crossing rate approaches are developed for combinations of time varying loads, then load factors are numerically obtained as a proposed model. The summation of log-normal random variables is treated to provide a simple load combination example.Finally the definition of limit state design is discussed to increase the rationality of further development. A few future problems are also summarized with an emphasis on the improvement of the probabilistic model of load and the theoretical basis for the target reliability.", "funder_award_id": "01302047", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 10400000.0, "currency": "JPY", "funding_type": "grant", "funder_scheme": "Grant-in-Aid for Co-operative Research (A)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01302047/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Jun", "family_name": "KANDA", "orcid": null, "role_start": null, "affiliation": {"name": "Dept.of Architecture, Faculty of Engineering, The University of Tokyo", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000080134477", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088826331", "display_name": "Encoding social arousal within prepronociceptin circuits in the extended amygdala", "description": "PROJECT NARRATIVE In our daily lives, we rely on our brains’ ability to recognize social stimuli as safe or threatening in order to approach or avoid them. Our research will reveal key components of the complex neurocircuitry that is necessary to regulate social arousal, ultimately leading to discoveries that define the relationship between arousal and behavior, as well as pinpoint circuit mechanisms that can be targeted to develop better treatments for those suffering from disorders defined by maladaptive social behaviors.", "funder_award_id": "5r01mh132073-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 655071.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2023-09-08", "end_date": "2028-05-31", "start_year": 2023, "end_year": 2028, "landing_page_url": "https://reporter.nih.gov/project-details/10925357", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOSE", "family_name": "RODRIGUEZ-ROMAGUERA", "orcid": null, "role_start": null, "affiliation": {"name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088826410", "display_name": "Not Available", "description": null, "funder_award_id": "CEECINST/00056/2021/CP2804/CT0003", "funder": {"id": "https://openalex.org/F4320334779", "display_name": "Fundação para a Ciência e a Tecnologia", "doi": "10.13039/501100001871"}, "amount": 58184.44, "currency": "EUR", "funding_type": "grant", "funder_scheme": "FCT", "start_date": "2022-12-15", "end_date": "2028-12-14", "start_year": 2022, "end_year": 2028, "landing_page_url": "https://sciproj.ptcris.pt/12574EEC", "doi": "http://dx.doi.org/10.54499/ceecinst/00056/2021/cp2804/ct0003", "provenance": "crossref_work", "lead_investigator": {"given_name": "Teresa", "family_name": "Sarmento Henriques", "orcid": "http://orcid.org/0000-0002-4032-9594", "role_start": null, "affiliation": null}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408882763", "display_name": "CARBOHYDRATE STRUCTURE AND IMMUNE FUNCTION", "description": null, "funder_award_id": "1r15ai034108-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R15", "start_date": "1994-07-15", "end_date": "1997-07-14", "start_year": 1994, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/2069194", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KENTON STUART", "family_name": "MILLER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF TULSA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088828712", "display_name": "600MHz NMR Spectrometer", "description": "Project narrative The requested nuclear magnetic resonance (NMR) spectrometer will provide essential analytical capabilities for 150+ scientists at Northeastern University conducting NIH-supported research, which provides public health benefits including discovery of new anticancer drugs, nanotechnology for targeted drug delivery and tissue engineering, treatments for malaria and neglected global diseases like sleeping sickness, non-addictive medications for chronic pain, and treatments for addiction to cocaine or methamphetamine.", "funder_award_id": "1s10od032452-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1566116.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "S10", "start_date": "2022-04-15", "end_date": "2024-04-14", "start_year": 2022, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10431284", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JASON JIANXIN", "family_name": "GUO", "orcid": null, "role_start": null, "affiliation": {"name": "NORTHEASTERN UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088828998", "display_name": "Stochastic approximations and differential inclusions: Applications to evolutionary processes", "description": null, "funder_award_id": "137273", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 48200.0, "currency": "CHF", "funding_type": "fellowship", "funder_scheme": "Fellowships for prospective researchers", "start_date": "2011-11-01", "end_date": "2012-10-31", "start_year": 2011, "end_year": 2012, "landing_page_url": "https://data.snf.ch/grants/grant/137273", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Roth,", "family_name": "Grégory", "orcid": null, "role_start": null, "affiliation": {"name": "Institution abroad - United States of America", "country": "United States of America", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088829135", "display_name": "THE STUDY OF EMOTIONAL PROCESSES IN SCHIZOPHRENIA", "description": null, "funder_award_id": "1k23mh001839-01a1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 177833.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2000-08-25", "end_date": "2005-07-31", "start_year": 2000, "end_year": 2005, "landing_page_url": "https://reporter.nih.gov/project-details/6195314", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHRISTIAN G", "family_name": "KOHLER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PENNSYLVANIA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088830534", "display_name": "Assembly and ultrastructure of septins, from the molecule to the cell", "description": "Septins are cytoskeletal proteins that assemble into filamentous structures at the inner cell membrane. They were originally discovered in budding yeast as cell division cycle mutants and are indeed involved in cytokinesis, the last step of cell division. In higher eukaryotes, septins are also involved in cytokinesis as well as in many other cellular functions such as cellularization in Drosophila embryos. Septins are linked to human neurodegenerative diseases like Parkinson and Alzheimer and also tumorogenesis. Compared to other cytoskeletal components like actin, septins display a highly variable ultra-structural organization. I previously performed pioneering studies to describe the molecular and supramolecular 3D architecture of budding yeast septins in vitro and in situ by electron microscopy (EM). The budding yeast mitotic septin complex associated into a minimal linear and symmetric octameric complex that can further assemble into non polar filaments. Model biomembranes were key tools to demonstrate that the supramolecular organizations of septins are is driven by interaction of septins with a specific lipid, PI(4,5)P2. I also showed that septins in situ organize into an orthogonal network of filaments, close to the inner cell membrane. The goal of this project is to reveal the universal features required for the assembly and ultrastructure of septin filaments and higher-order structures, which govern the biological function of this unconventional type of cytoskeletal filament. To this end, our investigations will be using two distinct model systems: budding yeast S. cerevisiae and drosophila melanogaster. Drosophila septins subunits differ from yeast septins in number and composition, their structural organizations are not yet characterized and our preliminary result revealed that their assembly into filaments differs from that of budding yeast. We will pursue three specific aims: - Understand the role of the different architectures of septins in membrane remodeling and lipid domain reorganization. This aim involves the complete description of the ultrastructure of drosophila septins. We will notably correlate the formation of various architectures of septins to the changes of the morphology of different model biomembranes, namely lipid monolayer and large and giant unilamellar vesicles, representative of different states of membrane remodeling. - Analyze the dynamical assembly of septins on membranes and its consequence for building a diffusion barrier for sequestering membrane bound and transmembrane proteins. - Describe the 3D organization of septins in situ within mitotic budding yeasts and cellularizing Drosophila embryos to reveal the common and different structural parameters involved in the function of septin in cytokinesis and in cellularization. A complementary combination of cutting edge methods will be used (cryo-EM, tomography, image analysis electron tomography, (high-speed) Atomic Force Microscopy (AFM), super-resolution optical fluorescence microscopy) in a multi-scale study going from the molecule to the cell. This project will profit from the synergy of the extensive expertise of A. Bertin on the variable and dynamical organizations of budding yeast septins and of collaborators of the Curie Institute Daniel Levy, expert of the structural analysis of transmembrane proteins by electron microscopy and of biomimetic membrane models and the facilities of the Curie Institute (Electron microscopy, photonic microscopy). The project will further benefit from external collaborations (P.EM. Milhiet, Atomic Force microscopy; M. Mavrakis, septins in drosophila development; G. Koenderink, biophysics of septins). Altogether these studies will be invaluable to understand the mechanisms of formation of septin networks leading to cell membrane reorganization during cell division.", "funder_award_id": "ANR-13-JSV8-0002", "funder": {"id": "https://openalex.org/F4320320883", "display_name": "Agence Nationale de la Recherche", "doi": "10.13039/501100001665"}, "amount": 249924.48, "currency": "EUR", "funding_type": "grant", "funder_scheme": "JC", "start_date": "2014-01-01", "end_date": null, "start_year": 2014, "end_year": null, "landing_page_url": "https://anr.fr/Projet-ANR-13-JSV8-0002", "doi": null, "provenance": "anr_opendata", "lead_investigator": {"given_name": "Aurélie", "family_name": "BERTIN", "orcid": null, "role_start": null, "affiliation": {"name": "INSTITUT CURIE - SECT DE RECHERCHE", "country": "France", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088833020", "display_name": "COMPREHENSIVE GEOCHARACTERIZATION OF SANTEE FORMATION AND ITS IMPLICATIONS FOR ENGINEERING BEHAVIIOR AT SRS", "description": "COMPREHENSIVE GEOCHARACTERIZATION OF SANTEE FORMATION AND ITS IMPLICATIONS FOR ENGINEERING BEHAVIIOR AT SRS", "funder_award_id": "FC09-08SR22631", "funder": {"id": "https://openalex.org/F4320306084", "display_name": "U.S. Department of Energy", "doi": "10.13039/100000015"}, "amount": 1221018.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "MISCELLANEOUS FEDERAL ASSISTANCE ACTIONS", "start_date": "2008-09-24", "end_date": "2012-09-10", "start_year": 2008, "end_year": 2012, "landing_page_url": "https://www.usaspending.gov/award/ASST_NON_FC09-08SR22631_089/", "doi": null, "provenance": "usaspending", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088833834", "display_name": "GENETIC ANALYSIS OF NEMATODE EGG-LAYING", "description": null, "funder_award_id": "2r01gm024663-09", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1978-01-01", "end_date": "1990-12-31", "start_year": 1978, "end_year": 1990, "landing_page_url": "https://reporter.nih.gov/project-details/3272430", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "H R", "family_name": "HORVITZ", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS INSTITUTE OF TECHNOLOGY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088839473", "display_name": "REGULATION OF INSULIN SECRETION BY TARGETING PKA AND CAN", "description": null, "funder_award_id": "5k11dk002353-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K11", "start_date": "1995-07-01", "end_date": "2000-06-30", "start_year": 1995, "end_year": 2000, "landing_page_url": "https://reporter.nih.gov/project-details/2733800", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "LINDA B", "family_name": "LESTER", "orcid": null, "role_start": null, "affiliation": {"name": "OREGON HEALTH AND SCIENCE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088840695", "display_name": "ION CHANNELS IN THE FUNCTIONING OF CORTICAL NEURONS", "description": null, "funder_award_id": "5r01ns030676-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 231571.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1992-12-01", "end_date": "2002-05-31", "start_year": 1992, "end_year": 2002, "landing_page_url": "https://reporter.nih.gov/project-details/6187846", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JEANNE M", "family_name": "NERBONNE", "orcid": null, "role_start": null, "affiliation": {"name": "WASHINGTON UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088841607", "display_name": "SEDarc Post-Doctoral Fellowship 2024 - Victoria Lister", "description": "The aims of this fellowship are to develop and extend the impact of the fellow's PhD research on voyeurism through (1) disseminating findings to key stakeholders, policymakers, and practitioners, and (2) building networks of national and international collaborators. This fellowship will provide the fellow with an opportunity to (3) produce numerous PhD-related publications, and (4) learn new research methodologies to support the development of a post-doctoral fellowship funding application. Fulfilment of these aims will enable the fellow to strengthen and extend their network of professional contacts internationally, improve research skills and understanding of user organisations, and establish a strong research track record for success.\n\nTo achieve aims 1 and 2, a free-to-attend one-day impact and engagement event will be organised, inviting multidisciplinary professionals whose work intersects with voyeurism (i.e., academics, policymakers, and practitioners). At this event, the fellow will provide a keynote lecture about voyeurism and the concerns around its definition as highlighted by her PhD research. Breakout sessions with additional invited speakers and networking sessions will be facilitated where delegates will engage in a World Café event regarding contemporary issues surrounding voyeurism. This impact event will reframe how professionals in the field view and define voyeurism—using findings from the fellow's thesis—to kickstart conversations relevant to policy and practice.\n\nThe fellow will also attend and present at two conferences: the National Organisation for the Treatment of Abuse annual conference (UK) and the International Association for the Treatment of Sexual Offenders bi-annual conference (Poland). Both conferences are renowned in the field of sexual offending and attract delegates globally including academics, practitioners, and policymakers. These conferences will be used to disseminate the fellow's findings among a diverse audience, allowing opportunities to build networks of global collaborators.\n\nTo achieve aim 3, publications from the fellow's PhD will be submitted during the fellowship: (1) the final empirical study of the fellow's PhD thesis highlighting key characteristics associated with voyeurism will be revised for publication, and (2) the general discussion from the fellow's PhD thesis will be developed and written up as a commentary paper for a high impact journal. This is likely to be a pivotal publication for the field; highlighting concerns about the definition of voyeurism and the discrepancies between how it is viewed and reported on by academics, practitioners, and in legislation.\n\nTo achieve aim 4, the fellow will visit the Centre for Forensic Behavioural Science (CFBS) at Swinburne University of Technology for four weeks. During this visit, the fellow will hold a dissemination event for academics, policymakers, and practitioners in Australia and New Zealand where the fellow's findings will be presented. This will ensure dissemination of the findings beyond Europe (aim 1) and international network development for future collaboration (aim 2). The fellow will also learn new research methodologies, such as case and court file reviews and data linkage approaches, in which the CFBS has extensive expertise. Such methodologies are specifically applicable to less commonly occurring offences, such as voyeurism, and will be extremely valuable for the fellow's future research. This research visit will also allow the fellow to scope out the possibility of qualitative research in Australia in the future. Utilising the skills and techniques learnt, the fellow will develop a strong research proposal, identify post-doctoral funding, and prepare applications for these to kickstart a career in academia.", "funder_award_id": "ES/Z504257/1", "funder": {"id": "https://openalex.org/F4320334630", "display_name": "Economic and Social Research Council", "doi": "10.13039/501100000269"}, "amount": null, "currency": "GBP", "funding_type": "fellowship", "funder_scheme": null, "start_date": "2024-09-30", "end_date": "2025-09-29", "start_year": 2024, "end_year": 2025, "landing_page_url": "https://gtr.ukri.org/projects?ref=ES/Z504257/1", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088841954", "display_name": "INFLUENCE OF AGE ON LEFT VENTRICULAR DIASTOLIC FUNCTION", "description": null, "funder_award_id": "1z01hl004138-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3942939", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "P", "family_name": "SPIRITO", "orcid": null, "role_start": null, "affiliation": {"name": "HEART, LUNG, AND BLOOD INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088848140", "display_name": "MECHANISMS OF ACTION OF PSYCHOACTIVE DRUGS", "description": null, "funder_award_id": "1z01mh002468-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3880971", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "X-M", "family_name": "GAO", "orcid": null, "role_start": null, "affiliation": {"name": "NATIONAL INSTITUTE OF MENTAL HEALTH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088848836", "display_name": "骨腫瘍に伴う骨膜反応のIP法による形態画像診断と機能解析", "description": "Principal Investigator：山根 良, Project Period (FY)：1992, Research Category：Grant-in-Aid for Encouragement of Young Scientists (A), Research Field：外科・放射線系歯学", "funder_award_id": "04771772", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 900000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (A)", "start_date": "1992-04-01", "end_date": "1992-03-31", "start_year": 1992, "end_year": 1992, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04771772/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088849029", "display_name": "Prolactin Regulates the Uterine response to Progesterone", "description": null, "funder_award_id": "5r01hd029457-13", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 326274.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1993-12-01", "end_date": "2009-04-30", "start_year": 1993, "end_year": 2009, "landing_page_url": "https://reporter.nih.gov/project-details/7035363", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BEVERLY S.", "family_name": "CHILTON", "orcid": null, "role_start": null, "affiliation": {"name": "TEXAS TECH UNIVERSITY HEALTH SCIS CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088850386", "display_name": "Recherche en géométrie algorithmique et stabilité des sols: caractériser les fractures à l'aide de méthode géométriques", "description": null, "funder_award_id": "341539", "funder": {"id": "https://openalex.org/F4320331165", "display_name": "Fonds de recherche du Québec", "doi": "10.13039/501100020951"}, "amount": 1500.0, "currency": "CAD", "funding_type": "award", "funder_scheme": null, "start_date": "2023-06-15", "end_date": "2024-06-14", "start_year": 2023, "end_year": 2024, "landing_page_url": "https://repertoire.frq.gouv.qc.ca/offres/detailOffres.do?methode=consulter&demId=341539", "doi": "https://doi.org/10.69777/341539", "provenance": "crossref_work", "lead_investigator": {"given_name": "Jun Kai", "family_name": "Liao", "orcid": null, "role_start": "2023-06-15", "affiliation": {"name": "Université McGill", "country": null, "ids": [{"id": "https://ror.org/01pxwe438", "type": "ROR", "asserted_by": "publisher"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088850854", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "256294-2001", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Industrial Undergraduate Student Research Awards", "start_date": "2002-04-01", "end_date": "2003-03-31", "start_year": 2002, "end_year": 2002, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=256294-2001", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Heidi(Song)", "family_name": "Vien", "orcid": null, "role_start": null, "affiliation": {"name": "Cantest Ltd", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088852086", "display_name": "RI: Small: Exploiting Global Structure in Robot Decision Problems", "description": "Some decision problems, like loading a dishwasher or assembling furniture, require explicit planning about a sequence of steps, while others, like grasping an object or swerving to avoid a stopped car, can be performed largely through learned reflexes. In robotics, it is still poorly understood why some problems require planning and why others can be solved via reflex. This project explores how techniques from topology, a branch of mathematics, can be applied to study the fundamental nature of robot decision problems. By developing algorithms that apply topology to optimize, analyze, and visualize large datasets of robot motions, the researchers hope to better understand the gray area between planning and learning. Ultimately, this better understanding could help other engineers develop more responsive, capable, and robust robot behaviors. \r\n\r\nThe technical goal of this research is to analyze the mathematical relation connecting robot decision problems to their solutions in order to shed light on fundamental questions surrounding the connection between motion planning and control learning. Breaking from the classical planning paradigm of developing an algorithm that solves individual problem queries, the project studies the global topological characteristics of continuous variations of related problem instances. Specifically, it investigates how certain features of topological complexity relate to the performance of learning and planning algorithms. Based on this understanding, new algorithms, topological metrics, and visualization techniques are developed to help exploit topological structure for faster planning and more accurate learning. The proposed methods are evaluated on benchmark problems in redundant inverse kinematics, legged robots, and agile autonomous vehicles.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.", "funder_award_id": "1816540", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 348774.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2018-08-15", "end_date": "2020-01-31", "start_year": 2018, "end_year": 2020, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1816540", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Kris", "family_name": "Hauser", "orcid": null, "role_start": null, "affiliation": {"name": "Duke University", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088857950", "display_name": "遺跡より出土するヒスイ玉の非破壊化学分析による産地同定と、交易ルートの推察", "description": "Principal Investigator：合地 信生, Project Period (FY)：2000, Research Category：Grant-in-Aid for Encouragement of Young Scientists (B), Research Field：地学", "funder_award_id": "12916001", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 300000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Encouragement of Young Scientists (B)", "start_date": "2000-04-01", "end_date": "2000-03-31", "start_year": 2000, "end_year": 2000, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12916001/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088860412", "display_name": "透析見合わせを選択した高齢者を看取った家族の経験", "description": "透析治療に関わる意思決定は患者の意思を尊重するため、共有意思決定（Shared decision making 以下SDM）が着目されているが、透析治療を受ける患者の多くは高齢者であり意思決定においては家族が関与している。しかし、SDMにおいては、家族支援は患者支援に内包され、患者の意思を確認できない時に代理意思決定を行う家族に対する支援方法は明らかにされていない。更に現在の透析見合わせを含む終末期における意思決定支援が患者の意思を尊重したものであるかを患者側から評価するアウトカム指標も明らかとなっていない。そのため、本研究は透析の見合わせを選択した高齢者を看取った家族の経験を明らかにする。", "funder_award_id": "21K21173", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2600000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Research Activity Start-up", "start_date": "2021-08-30", "end_date": "2025-03-31", "start_year": 2021, "end_year": 2025, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K21173/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "なつ美", "family_name": "清水", "orcid": null, "role_start": null, "affiliation": {"name": "Musashino University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020909113", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088860655", "display_name": "非平衡状態における抗コリンエステラーゼ薬の作用の検討", "description": "【背景】抗コリンエステラーゼ薬(抗ChE薬)は非脱分極性筋弛緩薬のリバースの目的で用いられる。エドロフォニウム(Ed)とネオスチグミン(Neo)がよく用いられるが、この2種の薬物で、その抗ChE作用の強さと筋弛緩リバースの効果に差があることが知られている。通常、抗ChE作用は基質の濃度がほぼ一定の平衡状態で測定される。しかし、運動神経終板においてはアセチルコリン(ACh)の存在時間は1ミリ秒あるいはそれ以下と考えられ、このように基質の濃度が急速に変化する状況では、そこでの反応は平衡状態での反応と異なることが予想される。今回の実験では、ACh濃度が急速に変化する条件で抗ChE作用の強さを測定し、従来の結果と比較した。【方法】ChE活性の測定はエルマン法を用いた。アセチルチオコリン(ATCh)とDTNBを含む燐酸緩衝液(A液)と、種々の濃度のEdまたはNeoを含む赤血球ゴ-スト(B液)を、ストップトフロー装置(RX.2000、Applied Photophysics)を用いて急速混和し、反応を開始させた。ATChの分解によって生じるチオコリン濃度を分光光度計(日本分光、Ubest-55)で測定し、反応開始直後とその後の平衡状態でのChE活性の変化を検討した。【結果および考察】ストップトフロー法でも、通常のエルマン法による測定と同様の結果が得られた。反応開始直後においても、その後の平衡状態においても、ChE活性に変化は認められなかった。また、これはEdまたはNeoの存在下においても同様であった。これらの結果は今回の研究の作業仮定を否定するものであるが、今回使用した分光光度計の時間解像度は最高でも50msecであり、このため高速な変化を十分捉えられなかった可能性もある。今後、時間解像度のさらに優れた装置を用いて実験を継続する予定である。", "funder_award_id": "08671737", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": null, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "1996-04-01", "end_date": "1996-03-31", "start_year": 1996, "end_year": 1996, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-08671737/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "吉夫", "family_name": "太田", "orcid": null, "role_start": null, "affiliation": {"name": "Okayama University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000030136006", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088861288", "display_name": "TESTOSTERONE EFFECTS ON GONADOTROPINS AND LIPIDS IN MEN", "description": null, "funder_award_id": "5k08hd000890-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K08", "start_date": "1990-09-01", "end_date": "1993-08-31", "start_year": 1990, "end_year": 1993, "landing_page_url": "https://reporter.nih.gov/project-details/3081429", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CARRIE J", "family_name": "BAGATELL", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF WASHINGTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088862627", "display_name": "地域の遺伝性乳癌卵巣癌症候群の診療体制構築を目指して", "description": "近年の乳癌診療の中で最も注目されているのが、BRCA遺伝学的検査結果を加味した治療である。ある一定の条件を満たす乳癌患者は、周術期にBRCA遺伝学的検査を受検し、遺伝性乳癌卵巣癌症候群（HBOC：Hereditary Breast and Ovarian Cancer）と診断されるか否かにより、術式や薬物療法などの治療方針が大きく変わる時代が訪れている。しかしその発展の一方で、乳癌治療を行っている小規模施設の中には、遺伝診療に不慣れで、急速な治療方針の転換に乗り遅れている施設も存在する。そのため地域のHBOC診療ネットワークを構築改善していくことを目的とし、本研究を立案した。", "funder_award_id": "24K20138", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for Early-Career Scientists", "start_date": "2024-04-01", "end_date": "2026-03-31", "start_year": 2024, "end_year": 2026, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24K20138/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "真緒", "family_name": "木本", "orcid": null, "role_start": null, "affiliation": {"name": "Mie University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000020747175", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088865661", "display_name": "Isotopes and Concerted Reaction Mechanisms", "description": null, "funder_award_id": "7034957", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1970-01-01", "end_date": "1971-01-01", "start_year": 1970, "end_year": 1971, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7034957", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088865793", "display_name": "Italienische und deutsche Architektur-Zeichnungen 16. und 17. Jahrhundert", "description": null, "funder_award_id": "38281", "funder": {"id": "https://openalex.org/F4320320924", "display_name": "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung", "doi": "10.13039/501100001711"}, "amount": 50000.0, "currency": "CHF", "funding_type": "grant", "funder_scheme": "Publication grants", "start_date": "1993-12-16", "end_date": "1994-01-15", "start_year": 1993, "end_year": 1994, "landing_page_url": "https://data.snf.ch/grants/grant/38281", "doi": null, "provenance": "snsf", "lead_investigator": {"given_name": "Reinle,", "family_name": "Adolf", "orcid": null, "role_start": null, "affiliation": {"name": "University of Zurich – ZH", "country": "Switzerland", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088866772", "display_name": "DERMAL ABSORPTION FROM SOILS--EVALUATION AND PREDICTION", "description": null, "funder_award_id": "5r01es006825-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-07-15", "end_date": "1998-06-30", "start_year": 1994, "end_year": 1998, "landing_page_url": "https://reporter.nih.gov/project-details/2155732", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANNETTE L", "family_name": "BUNGE", "orcid": null, "role_start": null, "affiliation": {"name": "COLORADO SCHOOL OF MINES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408886772", "display_name": "Training Grant in Pediatric Endocrinology, Diabetes and Metabolism", "description": "NARRATIVE More pediatric physician scientists are needed to define the pathophysiology of Pediatric Endocrine disease and to allow for the development of new treatments. Our program is one of approximately a dozen T32 grants devoted solely to Pediatric Endocrinology, and although relatively young, our graduates have begun to fill voids and assume academic leadership roles in pediatric endocrinology. This has allowed for a better understanding of and ultimate cure for disorders targeted as national public health priorities, including pediatric diabetes and obesity.", "funder_award_id": "5t32dk065522-18", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 240971.0, "currency": "USD", "funding_type": "training", "funder_scheme": "T32", "start_date": "2005-07-01", "end_date": "2025-06-30", "start_year": 2005, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10428470", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SHARON E.", "family_name": "OBERFIELD", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088868373", "display_name": "Investigations Targeting Symptomatic Relief to Botulinum Neurotoxin A Intoxicatio", "description": " Botulinum neurotoxins (BoNT) are the etiological agents responsible for botulism, are the most toxic proteins known to man and are potential bioterrorist weapons. To date there are no current interventions that can reverse the effects of BoNT intoxication once inside the cell. Our goals are to uncover small molecules that can act within an intoxicated cell to provide symptomatic relief to BoNT/A.", "funder_award_id": "5r01ai080671-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 445015.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2009-06-10", "end_date": "2014-05-31", "start_year": 2009, "end_year": 2014, "landing_page_url": "https://reporter.nih.gov/project-details/8268137", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KIM", "family_name": "JANDA", "orcid": null, "role_start": null, "affiliation": {"name": "SCRIPPS RESEARCH INSTITUTE, THE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088869808", "display_name": "Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss", "description": null, "funder_award_id": "5r01dc008577-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 361766.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-03-05", "end_date": "2013-02-28", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/8022842", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SHARON G", "family_name": "KUJAWA", "orcid": null, "role_start": null, "affiliation": {"name": "MASSACHUSETTS EYE AND EAR INFIRMARY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088870763", "display_name": "CAREER: Large-scale quantum-continuum simulation of layered metal oxide semiconductor photoelectrodes under finite-temperature electrochemical conditions", "description": "NON-TECHNICAL SUMMARY\r\n\r\nThe Division of Materials Research and the Division of Chemistry provide funding for this CAREER award, which supports computational research tightly integrated with educational and outreach activities aimed at broadening the palette of currently available photocatalytic materials.\r\n\r\nSolar energy is the most abundant energy source available to humankind, but this energy cannot be harnessed on demand due to the variability of sunlight. This CAREER award supports research and education in the specific area of artificial photosynthesis, which emulates natural photosynthesis, the sunlight-driven process used by plants to transform the carbon dioxide absorbed by their leaves and the water pumped by their roots into organic nutrients for supporting their survival and growth. Using artificial photosynthesis, carbon-neutral fuels can be produced.\r\n\r\nBy developing accurate computer models to predict the chemical transformations that underlie artificial photosynthesis, the PI and his research team aim at answering critical questions that surround the fuel-production ability of a promising family of materials that have been shown to absorb a much larger portion of the solar spectrum than previously used materials. The outcome of this research will be to expand the palette of materials that can efficiently operate under sunlight, and develop new software for understanding how small variations in the composition of a given material can affect its ultimate fuel-production performance. The new software will be disseminated to the community through an open-source distribution.\r\n\r\nThis CAREER award also supports a comprehensive educational and outreach plan to increase the participation of women and underrepresented groups in science and engineering with an emphasis on exposing them to the universe of computer programming and simulation, on developing effective teaching materials to train a computationally literate generation of young scientists and engineers, and on accelerating the emergence of a diverse and well-trained workforce in the area of materials modeling in an effort to reduce the time and cost involved in the industrial development of new energy materials.\r\n\r\nTECHNICAL SUMMARY\r\n\r\nThe Division of Materials Research and the Division of Chemistry provide funding for this CAREER award, which supports computational research tightly integrated with educational and outreach activities aimed at broadening the palette of currently available photocatalytic materials.\r\n\t\r\nSolar energy is the most abundant energy source available to humankind, but this energy cannot be harnessed on demand due to the variability of sunlight. Artificial photosynthesis provides a sustainable way to overcome that variability through the direct photocatalytic storage of solar power into chemical fuels; however, most of the stable photocatalysts in use today rely on metal oxide semiconductors whose bandgap does not match the solar spectrum, which greatly limits their overall performance.\r\n\r\nBy developing accurate molecular and submolecular models of electrochemical reactions at the interface between a semiconductor and an electrolyte under realistic environmental conditions, the PI and his research team aim to understand, predict, and control the surface mechanisms that underlie the operation of photochemical reactors towards maximizing their fuel-production performance. This CAREER project is specifically focused on studying layered metal oxide photocatalysts that can operate optimally under sunlight. In order to predict the properties of promising layered semiconductors, the PI will exploit and further develop a newly released quantum-continuum model to perform large-scale simulations of semiconductor-solution interfaces at finite temperature, taking into account the adsorption of ions and the response of explicit water layers under applied voltage. New software will be created in the open-source Quantum-Espresso distribution to provide the computational community with a widely applicable and highly transferable modeling framework for future studies of photocatalytic mechanisms at electrified photoelectrodes. \r\n\r\nThis CAREER award also supports a comprehensive educational and outreach plan to increase the participation of women and underrepresented groups in science and engineering with an emphasis on exposing them to the universe of computer programming and simulation, on developing effective teaching materials to train a computationally literate generation of young scientists and engineers, and on accelerating the emergence of a diverse and well-trained workforce in the area of materials modeling in an effort to reduce the time and cost involved in the industrial development of new energy materials.", "funder_award_id": "1654625", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 562873.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2017-02-01", "end_date": "2022-01-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=1654625", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Ismaila", "family_name": "Dabo", "orcid": null, "role_start": null, "affiliation": {"name": "Pennsylvania State Univ University Park", "country": "United States", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088873466", "display_name": "Using EMA to developmentally tailor an intervention to support on-demand PrEP among YMSM", "description": "Project Narrative Despite the availability of highly effective daily oral HIV pre-exposure prophylaxis (PrEP), uptake and adherence to PrEP among young men who have sex with men (YMSM) remains low. To achieve the goal of ending the HIV epidemic, increasing PrEP uptake among YMSM is critical. Exploring the potential for on- demand PrEP among YMSM, delivered in concert with developmentally tailored support interventions, has the potential to increase effective prevention adherence coverage among YMSM.", "funder_award_id": "5r21mh124678-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 157340.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2020-09-01", "end_date": "2023-02-28", "start_year": 2020, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10250523", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KEITH JOSEPH", "family_name": "HORVATH", "orcid": null, "role_start": null, "affiliation": {"name": "UNIV OF NORTH CAROLINA CHAPEL HILL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088873563", "display_name": "ENHANCEMENT OF CAPACITY FOR BIOMEDICAL RESEARCH", "description": null, "funder_award_id": "3g12rr003034-05s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "G12", "start_date": "1986-06-01", "end_date": "1991-05-31", "start_year": 1986, "end_year": 1991, "landing_page_url": "https://reporter.nih.gov/project-details/3058736", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JAMES A", "family_name": "GOODMAN", "orcid": null, "role_start": null, "affiliation": {"name": "MOREHOUSE SCHOOL OF MEDICINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088874572", "display_name": "ENANTIOSELECTIVE SYNTHESIS OF NATURAL PRODUCTS", "description": null, "funder_award_id": "5r37gm033061-20", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R37", "start_date": "1978-09-01", "end_date": "2002-03-31", "start_year": 1978, "end_year": 2002, "landing_page_url": "https://reporter.nih.gov/project-details/2684770", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ARTHUR G", "family_name": "SCHULTZ", "orcid": null, "role_start": null, "affiliation": {"name": "RENSSELAER POLYTECHNIC INSTITUTE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088875921", "display_name": "Using Technology to Prevent Obesity Among African American Girls", "description": " PROJECT NARRATIVE The purpose of this project is to reduce health disparities in obesity risk among 8-10 year old African American girls using a culturally sensitive and developmentally appropriate internet-based program with no face-to-face interaction. This study will conduct an outcome evaluation to test short and longer term effects on obesity risk. ", "funder_award_id": "1r01md005814-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 342500.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2010-09-30", "end_date": "2015-06-30", "start_year": 2010, "end_year": 2015, "landing_page_url": "https://reporter.nih.gov/project-details/8033617", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DEBORAH I", "family_name": "THOMPSON", "orcid": null, "role_start": null, "affiliation": {"name": "BAYLOR COLLEGE OF MEDICINE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088877329", "display_name": "EARLY T CELL DEVELOPMENT", "description": null, "funder_award_id": "1z01cm009310-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "intramural", "funder_scheme": "Z01", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/3853308", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "A M", "family_name": "KRUISBEEK", "orcid": null, "role_start": null, "affiliation": {"name": "CANCER TREATMENT", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088878451", "display_name": "TGF-beta 1 Regulation of Peripheral T Cell Tolerance", "description": null, "funder_award_id": "1k01ar053595-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 138240.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K01", "start_date": "2006-07-01", "end_date": "2007-06-30", "start_year": 2006, "end_year": 2007, "landing_page_url": "https://reporter.nih.gov/project-details/7081503", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MING", "family_name": "LI", "orcid": null, "role_start": null, "affiliation": {"name": "YALE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088879438", "display_name": "POPULATION BIOLOGY OF TEMPERATE AND TROPICAL LEPIDOPTERA", "description": null, "funder_award_id": "7202225", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1975-01-01", "end_date": "1976-01-01", "start_year": 1975, "end_year": 1976, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7202225", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088879514", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "224479-1999", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 4000.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "University Undergraduate Student Research Awards", "start_date": "1999-04-01", "end_date": "2000-03-31", "start_year": 1999, "end_year": 1999, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=224479-1999", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Scott", "family_name": "Irvine", "orcid": null, "role_start": null, "affiliation": {"name": "University of Lethbridge", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088879715", "display_name": "Artour Elfimov | Instituto de Física e Tecnologia - Geórgia", "description": "O objetivo do trabalho é o estudo teórico da influência de zonas locais de ressonâncias ciclotrônicas de impurezas na excitação de ondas de Alfvén globais e de superfície, no aquecimento em rotação de plasma. A estrutura e a dissipação dos campos eletromagnéticos de ondas de Alfvén serão estudados a partir das equações de Maxwell. A rotação do plasma e a geração de corrente serão investigadas através das forças ponderomotivas induzidas pelas ondas de Alfvén. Os resultados serão utilizados para o modelamento das experiências que serão realizadas no tokamak TCABR. (AU)", "funder_award_id": "97/04536-8", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "fellowship", "funder_scheme": "Auxílio à Pesquisa - Pesquisador Visitante - Internacional", "start_date": "1997-08-01", "end_date": "1997-12-31", "start_year": 1997, "end_year": 1997, "landing_page_url": "https://bv.fapesp.br/en/auxilios/97-04536-8/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Ivan", "family_name": "Cunha Nascimento", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Instituto de Física (IF)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088880837", "display_name": "Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older Adults", "description": "PROJECT NARRATIVE Our previous research has shown that those with severe-persistent and high-fluctuating suicide ideation are at increased risk for death by suicide and suicide attempt. Using actigraphy and digital monitoring, we will investigate how severity and fluctuation of affect, inter-daily stability of the 24-hour rest-activity rhythm, and sleep health relate to suicide risk in these two high suicide risk groups.", "funder_award_id": "3r01mh085651-13s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 194670.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2019-09-05", "end_date": "2024-06-30", "start_year": 2019, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10648538", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KATALIN", "family_name": "SZANTO", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF PITTSBURGH AT PITTSBURGH", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088881507", "display_name": "Globalization and the labour compact, 1870-1933", "description": null, "funder_award_id": "3324", "funder": {"id": "https://openalex.org/F4320334617", "display_name": "Social Sciences and Humanities Research Council of Canada", "doi": "10.13039/501100000155"}, "amount": 49329.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Standard Research Grants", "start_date": "2001-04-01", "end_date": null, "start_year": 2001, "end_year": null, "landing_page_url": "https://open.canada.ca/data/en/dataset/b4e2b302-9bc6-4b33-b880-6496f8cef0f1", "doi": null, "provenance": "sshrc_opendata", "lead_investigator": {"given_name": null, "family_name": "Huberman, Michael", "orcid": null, "role_start": null, "affiliation": {"name": "Université de Montréal", "country": "Canada", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088881865", "display_name": "Machine learning algorithms for analyzing auditory scenes with multiple sound sources", "description": "\r\n\r\nComputer algorithms that analyze auditory scenes and extract individual sound sources would have a strong impact in several domains. For example, to facilitate natural interaction with computing devices by voice, an automatic speech recognition system must be able to focus on the voice of the person speaking to it and ignore sounds from all other sources. A hearing device must perform a similar task to allow a hearing impaired person conduct a conversation in a noisy, multiple source environment. Building on recent advances in the fields of machine learning and signal processing, we are developing sophisticated adaptive algorithms for analyzing auditory scenes with multiple sound sources. Our algorithms are based on probabilistic modeling of different sound sources and of the manner in which they overlap each other and distorted by reverberation and background noise. We use advanced recent techniques for inferring our models from sound data captured by a microphone array, separating those data into individual sources, and automatically determining the type of each source present and its location. Moreover, by reconstructing the clean signal of individual sound sources, we dramatically enhance the accuracy of automatic speech recognition for human speakers in multiple source environments. To facilitate the development and evaluation of our algorithms, and also to encourage competition between other research groups ultimately resulting in improved techniques, we collect a large dataset of multiple source auditory scenes, and make it publicly available on a dedicated website.\r\n\r\n\r\n", "funder_award_id": "0535251", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 375000.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2006-01-01", "end_date": "2009-12-31", "start_year": 2006, "end_year": 2009, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0535251", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Terrence", "family_name": "Sejnowski", "orcid": null, "role_start": null, "affiliation": {"name": "University of California-San Diego", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408889339", "display_name": "No title - Aucun titre", "description": "No summary - Aucun sommaire", "funder_award_id": "258947-2002", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 3656.0, "currency": "CAD", "funding_type": "training", "funder_scheme": "Industrial Undergraduate Student Research Awards", "start_date": "2003-04-01", "end_date": "2004-03-31", "start_year": 2003, "end_year": 2003, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=258947-2002", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "AbdelHalim", "family_name": "Elamy", "orcid": null, "role_start": null, "affiliation": {"name": "Innovative Magnetic Resonance Imaging Systems Inc.", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088900548", "display_name": "Cartographier les acides biliaires d’origine microbienne produits dans l’intestin grêle par la métabolomique in vitro et in vivo", "description": "Les acides biliaires (ABs) participent à plusieurs processus physiologiques de l’hôte et sont impliqués dans le système immunitaire. La dérégulation métabolique des ABs est impliquée dans plusieurs maladies (p. ex., maladies inflammatoires de l’intestin, obésité, diabète de type 2). Ces molécules sont synthétisées dans le foie et relâchées dans le duodénum, où elles sont transformées en ABs secondaires par les bactéries qui y résident, puis réabsorbées partiellement dans l’iléon. Conséquemment, les bactéries qui habitent le tractus gastro-intestinal transforment les ABs primaires (issus de l’hôte) et peuvent donc influencer la physiologie de l’hôte. Grâce à la métabolomique non ciblée (analyse des molécules issues de l’organisme ou de divers environnements de faible poids moléculaire < 1500 daltons), un nouveau mécanisme de transformation des ABs primaires dans l’intestin grêle a été découvert. Des essais in vitro ont permis de cibler les espèces du genre Clostridioides comme responsables de ce nouveau mécanisme. Ces molécules ont été montrées comme affectant la régulation des ABs par leur liaison au récepteur clé de la synthèse des ABs primaires et comme possibles modulateurs du microbiote intestinal. Ainsi, cela démontre que malgré leur importance, nos connaissances sur l’étendue de ces transformations restent marginales. L’hypothèse sous-tendant mon projet de recherche est qu’en séparant l’hôte de son microbiote, il sera possible d’identifier de nouveaux ABs secondaires in vitro (p. ex., conjugaison d’autres acides aminés à l’acide cholique) et ensuite, confirmer leur présence in vivo. Pour tester cette hypothèse, des collections bactériennes seront construites en procédant à l’isolation des bactéries des trois organes de l’intestin grêle (duodénum, jéjunum, iléon) et la métabolomique non ciblée sera utilisée en association avec des outils bio-informatiques pour capturer ces nouveaux ABs secondaires inconnus. Découvrir ces ABs est important pour faire avancer nos connaissances concernant l’implication des ABs secondaires (dérivés des bactéries) dans le maintien de l’équilibre homéostatique des ABs dans le tractus gastro-intestinal. Finalement, la quantification en métabolomique ciblé (très sensible par rapport à une analyse non ciblée) des différents ABs primaires et secondaires, incluant ceux préalablement découverts in vitro, sera comparée entre des souris infectées à Salmonella enterica sérovar Typhimurium (STm; résistant aux ABs) et non infectées, puisque cette dernière est connue pour créer une dysbiose intestinale en inhibant des espèces de Clostridioides, impliquées dans la production d’ABs secondaires. L’utilisation de STm permettra d’évaluer comment la perturbation du microbiote intestinal crée un déséquilibre homéostatique des ABs et favorise le développement de l’agent pathogène. Ce projet de recherche vise donc à déterminer l’étendue des transformations que subissent les ABs primaires, les espèces responsables et comment ceux-ci sont impliqués dans le développement de maladies infectieuses causé par STm. Finalement, ce projet évaluera le rôle des ABs dans la création d’un environnement favorable à STm. Ces nouvelles connaissances ouvriront la voie à de nouvelles recherches sur la manière dont les agents pathogènes entériques favorisent leur établissement dans l’intestin et permettront d’optimiser les processus thérapeutiques visant les ABs dans les maladies inflammatoires et infectieuses.", "funder_award_id": "324772", "funder": {"id": "https://openalex.org/F4320331165", "display_name": "Fonds de recherche du Québec", "doi": "10.13039/501100020951"}, "amount": 110000.0, "currency": "CAD", "funding_type": "award", "funder_scheme": null, "start_date": "2023-05-15", "end_date": "2025-05-14", "start_year": 2023, "end_year": 2025, "landing_page_url": "https://repertoire.frq.gouv.qc.ca/offres/detailOffres.do?methode=consulter&demId=324772", "doi": "https://doi.org/10.69777/324772", "provenance": "crossref_work", "lead_investigator": {"given_name": "Vincent", "family_name": "Charron-Lamoureux", "orcid": null, "role_start": "2023-05-15", "affiliation": {"name": "Université de Sherbrooke", "country": null, "ids": [{"id": "https://ror.org/00kybxq39", "type": "ROR", "asserted_by": "publisher"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408890120", "display_name": "Studies of Hibernation and Digestion in Chiroptera;", "description": null, "funder_award_id": "5905898", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1959-01-01", "end_date": "1962-01-01", "start_year": 1959, "end_year": 1962, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=5905898", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088906516", "display_name": "Mechanisms Linking Hearing Loss and Alzheimer's Disease and Related Dementias", "description": "Age-related hearing loss (HL) is a common condition (present in over 80% of those over 80 years) that is associated with Alzheimer’s disease and related dementias (ADRD). The proposed award will support a career to clarify the mechanisms linking HL and ADRD, including whether HL is a cause, complication, or correlate of ADRD. This goal is in line with 2 goals of the National Alzheimer’s Project Act (NAPA) to “prevent and effectively treat Alzheimer’s disease by 2025,” and “expand supports for people with Alzheimer’s disease and their families.”", "funder_award_id": "5k23ag057832-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 164325.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K23", "start_date": "2018-04-15", "end_date": "2024-03-31", "start_year": 2018, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10396525", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JUSTIN SCOTT", "family_name": "GOLUB", "orcid": null, "role_start": null, "affiliation": {"name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088906523", "display_name": "The Last Census: Governing Britain with Metrics", "description": "Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.", "funder_award_id": "ES/G039259/1", "funder": {"id": "https://openalex.org/F4320334630", "display_name": "Economic and Social Research Council", "doi": "10.13039/501100000269"}, "amount": null, "currency": "GBP", "funding_type": "research", "funder_scheme": null, "start_date": "2009-04-30", "end_date": "2011-04-29", "start_year": 2009, "end_year": 2011, "landing_page_url": "https://gtr.ukri.org/projects?ref=ES/G039259/1", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G408890656", "display_name": "Colorado Summer Institute in Biostatistics (CoSIBS)", "description": "PUBLIC HEALTH RELEVANCE: The Colorado Summer Institute in Biostatistics (CoSIBS) will respond to the \"Call to Action\" to train the next generation of biostatisticians. The institute wil fill an important need in the western US. The program will be led by experienced senior teaching faculty with a strong commitment to biostatistics education. CoSIBS will inspire the next generation of biostatistician scientists to meet the long-term needs for new methods, study design, data analysis, and scientific leadership to assure the continued success of biomedical research as a cornerstone of public health practice and patient care.", "funder_award_id": "5r25hl131486-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 246086.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R25", "start_date": "2016-01-15", "end_date": "2018-12-31", "start_year": 2016, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/9412875", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JOHN", "family_name": "KITTELSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF COLORADO DENVER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088908611", "display_name": "NEURAL REGULATION OF PANCREATIC FUNCTION", "description": null, "funder_award_id": "5r01dk046285-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 141134.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1994-05-15", "end_date": "2004-07-31", "start_year": 1994, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6524108", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KIMBERLY SAUNDERS", "family_name": "KIRKWOOD", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA SAN FRANCISCO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088909505", "display_name": "Renal Tumor Marker by Monoclonal Antibodies Against Renal Cell Carcinoma", "description": "Murine IgM monoclonal antibodies (MAbs). 2D3 and 3E12. and IgG1 MAb 2E11 were prepared by the standard fusion methods against the established renal carcinoma (RC) cell line from perfused cells obtained from the renal vein of the tumorous kidney (CCF-RC2). In immunohistochemical analysis. 2D3.2E11 and 3E12 reacted with 13/23.2/11 and 21/23 of RC primary tumors and with a few other malignant tumor. Three MAbs reacted with normal renal tubular epithelium. 2D3 and 2E11 did not react with any other normal tissue examined except endothelium. We developed a double determinant enzyme immunoassay to detect tumor associated antigenin sera from RC patients using polyclonal Ab (anti-rabbit serum against RC cells) as first Ab and Mabs as the second Ab. This assay showed 3 out of 24 serum samples from RCC patients were positive and the remaining 21 serum samples, 3 serum samples from normal volunteers, and 6 urine specimens were negative. Although the positive rate was low, the results indicated that the circulating RCC antigens existed in the serum of RCC patients.", "funder_award_id": "01570890", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2000000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01570890/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Hideo", "family_name": "TAKEUTI", "orcid": null, "role_start": null, "affiliation": {"name": "Kyoto University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000070026954", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088911190", "display_name": "Hemodynamic responses to eletrical stimulation of the aortic depressor nerve and chemoreflex activation with potassium cyanide in unanesthetized rats.", "description": null, "funder_award_id": "97/03632-3", "funder": {"id": "https://openalex.org/F4320320997", "display_name": "Fundação de Amparo à Pesquisa do Estado de São Paulo", "doi": "10.13039/501100001807"}, "amount": null, "currency": "BRL", "funding_type": "conference", "funder_scheme": "Auxílio à Pesquisa - Reunião - Exterior", "start_date": "1997-09-12", "end_date": "1997-09-19", "start_year": 1997, "end_year": 1997, "landing_page_url": "https://bv.fapesp.br/en/auxilios/97-03632-3/", "doi": null, "provenance": "fapesp_bv", "lead_investigator": {"given_name": "Benedito", "family_name": "Honorio Machado", "orcid": null, "role_start": null, "affiliation": {"name": "Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)", "country": "Brazil", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088913921", "display_name": "Aging Memory", "description": "Public Health Relevance Narrative Statement Memory is fundamentally important to numerous aspects of our everyday lives, and disorders of memory that impair everyday functions are commonly observed in normal aging and Alzheimer's disease. Imagining or mentally simulating events that might occur in the future is crucial to adaptive function, important to planning for the future, and disrupted in healthy aging and Alzheimer's disease. Our work should yield novel insights that will enhance understanding of both neural and cognitive aspects of age-related changes in constructive memory and future imagining.", "funder_award_id": "5r01ag008441-29", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 537011.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1989-08-04", "end_date": "2022-11-30", "start_year": 1989, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/10073460", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "DANIEL L", "family_name": "SCHACTER", "orcid": null, "role_start": null, "affiliation": {"name": "HARVARD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088918232", "display_name": "Kooperativität in Bor und Kohlenstoffbasierten PinzettenKomplexen", "description": "Ziel dieses Projektes ist die Entwicklung einer neuen Art von Metall-Ligand kooperativen Bindungsaktivierung für Anwendungen in der Homogenkatalyse. Die im Fokus stehenden Übergangsmetallkomplexe enthalten Pinzetten-Liganden mit zentralen Donor-Gruppen, die auf den Elementen Bor und Kohlenstoff basieren. Wir haben entdeckt, dass Carbodiphosphoran-basierte (CDP) Rhodium(I)-Komplexe dieses Typs mit geminalen Dichloride unter oxidativer Addition und kooperativer Spaltung der zweiten C–Cl-Bindung reagieren. Die entstehenden Rhodium(III)-Komplexe enthalten formal ein CDP-stabilisiertes Carben als Ligand, was eine ungewöhnliche Bindungssituation darstellt, die im Rahmen diese Projektes für eine Reihe von Komplexen näher untersucht werden soll. Die zugrundeliegende Art der kooperativen Bindungsspaltung soll auf andere organische Dihalogene sowie auf geminale Dichloride der schweren Homologen der Gruppe 14 und der Elemente der Gruppe 13 übertragen werden. Basierend auf diesen Beobachtungen werden wir katalytische Reaktionen durch Verwendung geeigneter (möglichst nachhaltiger) Reduktionsmittel entwickeln, die die entstandene Rhodium(III)-Spezies zurück reduzieren und somit einen Transfer des stabilisierten Carbens induzieren. Die Synthese entsprechender Bor-basierter Komplexe, die formal ein Liganden-stabilisiertes Borid enthalten, stellt eine Herausforderung dar, die wir im Rahmen dieses Projektes bezwingen wollen. Dieses wollen wir durch die geeignete Wahl von Zentralatom, Liganden und stabilisierenden Substituenten am zentralen Bor-Atom realisieren. Die Reaktivität gegenüber ungesättigten, potentiell heterolytsch spaltbaren und Dihalogenid-Substraten werden wir mit der von entsprechenden CDP-basierten Komplexen vergleichen und entsprechende katalytische Reaktionen entwickeln.", "funder_award_id": "398626986", "funder": {"id": "https://openalex.org/F4320320879", "display_name": "Deutsche Forschungsgemeinschaft", "doi": "10.13039/501100001659"}, "amount": 109941.6654, "currency": "EUR", "funding_type": "grant", "funder_scheme": "Sachbeihilfen", "start_date": "2018-01-01", "end_date": "2018-12-31", "start_year": 2018, "end_year": 2018, "landing_page_url": "https://gepris.dfg.de/gepris/projekt/398626986", "doi": null, "provenance": "gepris", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088924460", "display_name": "DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO", "description": null, "funder_award_id": "5r01gm035437-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1975-07-01", "end_date": "1997-06-30", "start_year": 1975, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/2177896", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "KATHRYN V", "family_name": "ANDERSON", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA BERKELEY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088930115", "display_name": "In Vivo Characterization of Major ENCODE-Predicted Classes of Noncoding Elements", "description": "PROJECT NARRATIVE Most of the human genome is comprised of noncoding sequence, which contains millions of regulatory DNA elements that orchestrate the complex activities of individual genes as the human body develops, functions, and reacts to disease processes. While the ENCODE project has made incredible progress towards mapping these sequences and defining different classes based on their biochemical properties, their general function in the context of a living organism is poorly understood. This project will use targeted removal of individual regulatory sequences from the mouse genome as a model to understand the importance of noncoding sequences defined by the ENCODE project for the development and survival of mammalian organisms including humans.", "funder_award_id": "5um1hg009421-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 1348257.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "UM1", "start_date": "2017-02-01", "end_date": "2022-01-31", "start_year": 2017, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/9853829", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "LEN ALEXANDER", "family_name": "PENNACCHIO", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088931024", "display_name": "CHEMICAL AND BIOLOGICAL MIMICRY OF TELOMERASE", "description": null, "funder_award_id": "1r01gm069763-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 290714.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2004-02-01", "end_date": "2008-01-31", "start_year": 2004, "end_year": 2008, "landing_page_url": "https://reporter.nih.gov/project-details/6707227", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ERIC T.", "family_name": "KOOL", "orcid": null, "role_start": null, "affiliation": {"name": "STANFORD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088933139", "display_name": "New reagents for diagnosis of disease", "description": null, "funder_award_id": "2009-04390_Vinnova", "funder": {"id": "https://openalex.org/F4320321030", "display_name": "VINNOVA", "doi": "10.13039/501100001858"}, "amount": 400000.0, "currency": "SEK", "funding_type": "grant", "funder_scheme": "Project grant", "start_date": "2009-12-07", "end_date": "2011-12-31", "start_year": 2009, "end_year": 2011, "landing_page_url": "https://www.vr.se/english/swecris.html", "doi": null, "provenance": "swecris_vinnova", "lead_investigator": {"given_name": null, "family_name": "Peter Påhlsson", "orcid": "https://orcid.org/0000-0001-9338-1436", "role_start": "2009-12-07", "affiliation": {"name": "Linköping University", "country": "Sweden", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408893466", "display_name": "Understanding the causes of DNA methylation response to methylmercury: a novel approach to quantify genetic, environmental, and stochastic factors", "description": "PROJECT NARRATIVE Environmental chemicals that do not damage DNA may still contribute to environmental disease risk by disrupting chemical modifications to DNA that control gene expression, termed “epigenetic marks”; these modifications including DNA methylation. My research will leverage a unique study design to capture genetic, environmental, stochastic, and gene-environment interaction effects on DNA methylation of the neurotoxic heavy metal, methylmercury. This work will shed critical light on mechanisms underlying chemical effects on DNA methylation, which will directly enable public health protection from chemicals with epigenetic mechanisms of action.", "funder_award_id": "1k01es032044-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 154934.0, "currency": "USD", "funding_type": "career_development", "funder_scheme": "K01", "start_date": "2020-08-15", "end_date": "2023-07-31", "start_year": 2020, "end_year": 2023, "landing_page_url": "https://reporter.nih.gov/project-details/10039951", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CAREN", "family_name": "WEINHOUSE", "orcid": null, "role_start": null, "affiliation": {"name": "OREGON HEALTH & SCIENCE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088936380", "display_name": "競争と抗争の社会学的研究", "description": "Principal Investigator：安田 三郎, Project Period (FY)：1972, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：Sociology", "funder_award_id": "751038", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 800000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": "1972-04-01", "end_date": "1972-03-31", "start_year": 1972, "end_year": 1972, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-X00090----751038/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088936743", "display_name": "Functional Genomic Dissection of Refractory Anemia", "description": "PUBLIC HEALTH RELEVANCE: Myelodysplastic syndrome (MDS) is a disease of abnormal blood production that frequently progresses to acute leukemia. Heterozygous deletion of chromosome 5q is the most common chromosomal abnormality in MDS. We aim to understand how these deletions cause MDS and to understand how this genetic lesion can be targeted therapeutically.", "funder_award_id": "5r01hl082945-11", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 443750.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2005-09-15", "end_date": "2019-05-31", "start_year": 2005, "end_year": 2019, "landing_page_url": "https://reporter.nih.gov/project-details/9276717", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BENJAMIN LEVINE", "family_name": "EBERT", "orcid": null, "role_start": null, "affiliation": {"name": "BRIGHAM AND WOMEN'S HOSPITAL", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088938907", "display_name": "LECTINS AND SNAIL-TREMATODE ASSOCIATIONS", "description": null, "funder_award_id": "5r01ai024340-08", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1986-12-01", "end_date": "1994-11-30", "start_year": 1986, "end_year": 1994, "landing_page_url": "https://reporter.nih.gov/project-details/2062552", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ERIC S", "family_name": "LOKER", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF NEW MEXICO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088939865", "display_name": "Inflammation, Macrophage Differentiation, and Cancer", "description": null, "funder_award_id": "1ziabc010783-12", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 504913.0, "currency": "USD", "funding_type": "intramural", "funder_scheme": "ZIA", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://reporter.nih.gov/project-details/9779707", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ZHENG-GANG", "family_name": "LIU", "orcid": null, "role_start": null, "affiliation": {"name": "DIVISION OF BASIC SCIENCES - NCI", "country": null, "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088940468", "display_name": "Biopsychosocial influence on shoulder pain", "description": null, "funder_award_id": "5r01ar055899-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 429538.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2008-07-01", "end_date": "2013-04-30", "start_year": 2008, "end_year": 2013, "landing_page_url": "https://reporter.nih.gov/project-details/7799893", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEVEN Z", "family_name": "GEORGE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF FLORIDA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088941066", "display_name": "American Indian - Alaska Native Clinical and Translational Research Center (AI-AN CTRC)", "description": "PUBLIC HEALTH RELEVANCE: Alaska and Montana have significant Alaskan Native and American Indian populations, respectively, who experience some of the greatest health disparities of any ethnic or racial group. We propose to build clinical and translational research infrastructure that will develop and expand Native health research capacity in Alaska and Montana, which in turn will result in improved health of these Native people.", "funder_award_id": "3u54gm115371-02s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 10000.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U54", "start_date": "2016-08-01", "end_date": "2021-07-31", "start_year": 2016, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9669654", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BERT BRANDON", "family_name": "BOYER", "orcid": null, "role_start": null, "affiliation": {"name": "MONTANA STATE UNIVERSITY - BOZEMAN", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408894283", "display_name": "CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE", "description": null, "funder_award_id": "3r01gm020091-10s2", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1984-06-01", "end_date": "1988-03-31", "start_year": 1984, "end_year": 1988, "landing_page_url": "https://reporter.nih.gov/project-details/3269899", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERTO", "family_name": "LEVI", "orcid": null, "role_start": null, "affiliation": {"name": "WEILL MEDICAL COLLEGE OF CORNELL UNIV", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088945773", "display_name": "MINORITY ADOLESCENT HIV RESEARCH PROJECT", "description": null, "funder_award_id": "n01sc047037-011", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "contract", "funder_scheme": "N01", "start_date": "1994-09-30", "end_date": "1997-09-29", "start_year": 1994, "end_year": 1997, "landing_page_url": "https://reporter.nih.gov/project-details/2326395", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ANNTTE A", "family_name": "FICKER", "orcid": null, "role_start": null, "affiliation": {"name": "HOSPITAL FOR SICK CHLDRN (WASH, DC)", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088946640", "display_name": "Developing the predatory bacterium Bdellovibrio bacteriovorus as a novel therapy for treating canine otitis externa", "description": "Canine otitis media is a bacterial infection commonly caused by multi-drug resistant Pseudomonas aeruginosa1. Severe cases can result in the only remaining therapeutic option being surgery2,3, which may result in deafness (R. White pers comm). As such, novel approaches to antibacterial therapies are desperately needed. Bacteriophage, viruses that kill bacteria, are relatively well-studied alternatives to antibiotics, however resistance of the bacteria to bacteriophage can arise readily. Other 'living' antibacterials that do not result in such genetically-encoded resistance by the pathogen may represent a better alternative. The predatory bacterium Bdellovibrio bacteriovorus may be one such approach. Bdellovibrio bacteriovorus grows by preying upon susceptible Gram-negative bacteria, including many antibiotic-resistant pathogens, including Pseudomonas spp, E. coli, and Vibrio spp amongst others. We have previously shown that Bdellovibrio can effectively reduce the colonisation levels of Salmonella in chicks4, accompanied by an improvement in clinical symptoms; this has been followed by in vivo infection models involving Shigella5, Klebsiella6, Vibrio7 and Yersinia8 spp. Bdellovibrio are both self-replicating and self-limiting, both advantages over conventional antibiotics. In animal trials, Bdellovibrio does not cause harm8, at worst eliciting a temporary mild inflammation9. Bdellovibrio has been shown to efficiently kill prey growing in biofilms10, and as such it has potential for use against topical infections, such as external ear infections. The aim of this project is to determine the potential efficacy of Bdellovibrio therapy for the treatment of canine otitis externa caused by Pseudomonas aeruginosa, and to study the added potential of combinatorial predator therapy involving both Bdellovibrio and bacteriophage, building upon some of our recently published work11. Main objectives: 1: Quantify the predatory ability of Bdellovibrio to kill in vitro Pseudomonas aeruginosa isolates from cases of canine otitis media, both in pure and mixed cultures, containing other bacterial species co-isolated from the same clinical samples. 2: To build on previous data showing that killing of E. coli by the combination of a Bdellovibrio with a bacteriophage could result in complete eradication of prey in an in vitro assay, to look at the combinatorial effects of Bdellovibrio and either a) a Pseudomonas phage against a pure culture of Pseudomonas, or b) a phage targeting a second bacterial species, against a mixed culture of Pseudomonas and a second species. 3: Assess the efficacy of Bdellovibrio predation on Pseudomonas cells forming biofilm structures in the presence of epithelial cells. Using a published tissue culture-based approach whereby P. aeruginosa forms biofilms on monolayers of epithelial cells12,13, Bdellovibrio predation in the presence of both bacterial prey and epithelial cells will be studied, such as would be encountered during therapy. Together these objectives will reveal the potential efficacy of Bdellovibrio, and combinatorial therapies with bacteriophage in complex, multi-species populations of bacteria. It will inform us as to the best approaches to take in future in vivo therapeutic trials (outside the scope of this project). As Pseudomonas aeruginosa is both an animal and human pathogen, this project may lead to new therapeutic approaches for a variety of infections.", "funder_award_id": "2275714", "funder": {"id": "https://openalex.org/F4320334629", "display_name": "Biotechnology and Biological Sciences Research Council", "doi": "10.13039/501100000268"}, "amount": null, "currency": "GBP", "funding_type": "studentship", "funder_scheme": null, "start_date": "2019-09-30", "end_date": "2023-11-25", "start_year": 2019, "end_year": 2023, "landing_page_url": "https://gtr.ukri.org/projects?ref=2275714", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088950986", "display_name": "Modeling and empirical studies of arboviruses in Florida", "description": null, "funder_award_id": "5r01ai042164-10", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 447917.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "1999-02-01", "end_date": "2011-04-30", "start_year": 1999, "end_year": 2011, "landing_page_url": "https://reporter.nih.gov/project-details/7414034", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CYNTHIA C", "family_name": "LORD", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF FLORIDA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088953790", "display_name": "画像データを用いた魚群行動のモデリングに関する研究", "description": "Principal Investigator：三宮 信夫, Project Period (FY)：1985, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：計測・制御工学", "funder_award_id": "60550295", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1900000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for General Scientific Research (C)", "start_date": "1985-04-01", "end_date": "1985-03-31", "start_year": 1985, "end_year": 1985, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60550295/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088961616", "display_name": "発生工学を用いた心不全の病態解明と心血管再生細胞移植治療における骨髄幹細胞の役割", "description": "【目的】骨髄単核球移植による血管新生効果が臨床的にも確立されている。内皮系幹細胞の関与が大きいが新生血管内皮に集積する細胞起源は明らかでない。骨髄由来単球系幹細胞の内皮細胞分化の可能性とバルーン傷害血管での内皮再生による内膜肥厚の抑制効果を検討する。【方法】骨髄由来単球系幹細胞はCD14陽性細胞をソートして採取しVEGF存在下で培養し、造血系細胞マーカー、内皮系マーカー、間葉系マーカー抗体にて免疫染色行い分化誘導を検討した。ヌードラット頸動脈をバルーン傷害して内膜肥厚モデルを作製し、直後にPKH2-GL蛍光染色したヒト骨髄由来CD14陽性細胞を動脈内に投与した。【結果および考察】VEGF存在下で培養された骨髄由来CD14陽性細胞はVEGF存在下で造血系細胞マーカー(CD14,CD45,CD11b)を失い、内皮系マーカー(Tie2,CD34,Flk)出現が観察された。間葉系マーカーは陰性であった。バルーン傷害後に移植された骨髄CD14陽性細胞は傷害部位にMCP-1依存性に接着し、内膜肥厚を完全に抑制した。末梢血由来CD14陽性細胞では接着は観察されなかった。接着した骨髄CD14陽性細胞は造血系細胞マーカー(CD14,CD45,CD11b)を失い、内皮系マーカー(vWF, eNOS)を発現していた。再生内皮はエバンスブルーの侵出が抑制され、アセチルコリン依存性の拡張を示した。HUVECを用いたflow assayではMCP-1で刺激された骨髄CD14陽性細胞が明らかに高い接着能を示した。骨髄由来CD14陽性単球系幹細胞はbeta-integrin定常発現量が末梢血由来CDl4陽性単球系細胞より著明に元進していた。MCP-1により活性化beta-integrinが増加していた。CCR2発現は差がなかった。【結論】骨髄由来単球系幹細胞は内皮前駆細胞への分化能を持ち、MCP-1依存性にバルーン傷害内膜に強固に接着した。内皮再生により内膜肥厚は抑制され再狭窄も阻止された。PTCA後の内皮再生を目的とした細胞治療に応用可能と考えられた。", "funder_award_id": "12136207", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 72200000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research on Priority Areas", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12136207/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "弘明", "family_name": "松原", "orcid": null, "role_start": null, "affiliation": {"name": "Kyoto Prefectural University of Medicine(2003-2004)Kansai Medical University(2000-2002)", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000010239072", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088962316", "display_name": "Role of NGF in inflammatory and proliferative cascades of psoriatic disease", "description": "Psoriasis is a disease with flakey skin, and can be associated with arthritis of joints of hands, wrist, feet, ankle, knee, and spine. Nearly 2% of American population has psoriasis and 8-10% of psoriasis patients develop psoriatic arthritis. Psoriasis and psoriatic arthritis are life long chronic debilitating disease. A large number of the VA patient population suffers from these diseases. Cause of psoriatic arthritis is not known, treatment options for psoriatic arthritis are limited and worldwide only a few investigators are doing research to understand the disease process of psoriatic arthritis. In this proposed research project we will be investigating the role of nerve growth factor (NGF) in the disease process of psoriasis and psoriatic arthritis. NGF is a chemical mainly helps in to grow nerves in the embryo. NGF also irritates skin and other human body parts; in scientific language this is called inflammation. NGF is produced by skin cells and joint cells (synovial cells) and many other cells. NGF has a contributing role in several diseases including psoriasis. In this study we are doing a very important research work to find out how NGF causes psoriasis, induces inflammation and pain in psoriatic arthritis. Here we will transplant uninvolved skin from psoriasis patients and skin of normal healthy subjects to immune deficient mouse. We will collect blood cells from psoriasis patients and healthy subjects; we will treat these blood cells with NGF. These NGF treated cells will be injected into the transplanted human skin on mice. We expect that the injection of NGF treated blood cells from psoriasis patients will create psoriasis only in the mice transplanted with skin from psoriasis patients. Thus these experiments may help us to understand whether blood cells and NGF are responsible for causing psoriasis. Currently we are determining whether joint tissues from psoriatic arthritis has increased level of NGF and whether NGF is damaging the joint by altering the immune system. To determine these goals we are studying blood, joint fluid and joint tissues from patients with psoriatic arthritis and other forms of arthritis such as rheumatoid arthritis and osteoarthritis. Our initial results suggest that joint fluid of psoriatic arthritis has more NGF compared to rheumatoid arthritis and osteoarthritis. We have also noticed that NGF is likely activating a special group of immune cells (T lymphocytes) in the joint. It is possible that increased level of NGF and the hyperactive T cells have a contributing role to cause the joint inflammation. In a very recent animal experiment we have demonstrated that psoriasis can be treated by medicines which can neutralize the inflammatory effect of NGF. It is possible to develop nontoxic and effective medicines by neutralizing the bad effects of NGF. Our research work will help to understand the cause of psoriatic disease and thus to develop better patient care and treatment of psoriasis and arthritis. The success of this project will help the VA patient population immensely because both psoriasis and arthritis related sickness is a major problem among this group of patients.", "funder_award_id": "5i01cx000201-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "I01", "start_date": "2009-04-01", "end_date": "2012-09-30", "start_year": 2009, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/8195981", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "SIBA P", "family_name": "RAYCHAUDHURI", "orcid": null, "role_start": null, "affiliation": {"name": "VA NORTHERN CALIFORNIA HEALTH CARE SYS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088963612", "display_name": "Tracking the dynamics of how schemas scaffold recall", "description": "Project Narrative In my dissertation, I will use newly-developed machine learning techniques to study how the brain uses prior knowledge (about the spatial structure of an environment, or how certain types of events unfold in time) to scaffold new learning. By precisely characterizing how this scaffolding process works, my research will help to identify ways in which prior knowledge can be more optimally leveraged to support learning. This will lead to the development of tools to help memory-impaired individuals make better use of intact prior knowledge to support new learning, as well as remedies for groups where deficiencies in prior knowledge prevent them from learning properly.", "funder_award_id": "1f99ns120644-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 47036.0, "currency": "USD", "funding_type": "fellowship", "funder_scheme": "F99", "start_date": "2021-01-01", "end_date": "2022-12-31", "start_year": 2021, "end_year": 2022, "landing_page_url": "https://reporter.nih.gov/project-details/10156352", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROLANDO", "family_name": "MASIS", "orcid": null, "role_start": null, "affiliation": {"name": "PRINCETON UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088964099", "display_name": "CANCER PREVENTION CAMPAIGN", "description": null, "funder_award_id": "5u01ca051687-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "1989-09-30", "end_date": "1994-08-31", "start_year": 1989, "end_year": 1994, "landing_page_url": "https://reporter.nih.gov/project-details/3549479", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "JILL", "family_name": "VARNES", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF FLORIDA", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088965298", "display_name": "Analysis of abnormal tongue movement by three dimensional tongue movement measurement device with bimorph piezopolymer thin film", "description": "The subjects of this research was composed of normal occlusion 1 case and openbite 1 case which had obtained the agreement of cooperation for this research. The sensor which arranged five bimorph piezopolymer thin films was arranged by three rows in the direction of tongue's sagittal plane. However, the curvature on the lateral side was considerably smaller than the curvature in dorsum of tongue central part. The characteristic of the curvature was also similar to the curvature in central part. It was enough in the measurement only of tongue central part in tongue movement at swallowing in the above-mentioned reason.The results were at follows.1.In normal occlusion case, the curvature of the sensor in the dorsum of tongue was large, and upward in the dorsum of tongue was admitted. However, in openbite case, the curvature in the dorsum of tongue was small and the dorsum of tongue was a smooth tendency while swallowing.2.In normal occlusion case, the downward in the dorsum of tongue had started before the tongue tip reached an uppermost position, and after the tongue tip reached an uppermost position, the dorsum of tongue was located most downward. In openbite case, the beginning time of the dorsum's downward was similar to the normal occlusion case. However, amount of the movement on the tongue tip was small, the descent of the dorsum of tongue appeared at the early stage compared to the normal occlusion case, and dorsum of tongue had been located most downward before the tip of tongue was located in uppermost one.From the above-mentioned result, it was guessed that the compensatory tongue movement which had been adapted to anterior openbite occurred to maintain a negative air pressure for swallowing. Because the subjects were few, subjects should be increased in the next research.", "funder_award_id": "08672377", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 2300000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-08672377/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Yoichi", "family_name": "MARUYAMA", "orcid": null, "role_start": null, "affiliation": {"name": "Nagasaki University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050173969", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088966167", "display_name": "The role of small RNA derived tRNAs in gene regulation: Mechanism and Therapeutic Applications", "description": "NARRATIVE tRNA derived small RNAs (tsRNAs) represent a class of non-coding RNAs that play important yet not well defined roles in gene regulation. We further define a novel mechanism by which a specific tsRNA regulates ribosome biogenesis. We will establish if other tsRNA species have similar models of regulation. Finally, we will manipulate these RNAs using gene therapy and oiigonucleotide delivery and establish their therapeutic potential in human disease states", "funder_award_id": "1r01dk114483-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 527823.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2017-08-01", "end_date": "2021-07-31", "start_year": 2017, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9365781", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "MARK A", "family_name": "KAY", "orcid": null, "role_start": null, "affiliation": {"name": "STANFORD UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088966931", "display_name": "Probing molecular mechanisms of neurodegenerative ageing in prion ablated mice", "description": "Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.", "funder_award_id": "BB/C506356/3", "funder": {"id": "https://openalex.org/F4320334629", "display_name": "Biotechnology and Biological Sciences Research Council", "doi": "10.13039/501100000268"}, "amount": null, "currency": "GBP", "funding_type": "research", "funder_scheme": null, "start_date": "2008-04-30", "end_date": "2009-02-28", "start_year": 2008, "end_year": 2009, "landing_page_url": "https://gtr.ukri.org/projects?ref=BB/C506356/3", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088967992", "display_name": "Impacts of mechanosensation and matrix architecture on cell fate specification in traumatic heterotopic ossification", "description": "Project Narrative Heterotopic ossification (HO) is the pathologic formation of extra-skeletal bone that forms almost exclusively at sites of mechanical stress. We purport that discoidin domain receptor 2 (DDR2) and injury site immobilization modify extra-cellular matrix alignment and thus changes cell fate through downstream mechanotransductive signaling. Determination of the underlying mechanisms responsible for HO will enable us to validate clinically relevant mobilization protocols and mechanotransductive therapies to combat this currently untreatable disease.", "funder_award_id": "5r01ar078324-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 435118.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2021-07-15", "end_date": "2026-04-30", "start_year": 2021, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10448303", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "BENJAMIN", "family_name": "LEVI", "orcid": null, "role_start": null, "affiliation": {"name": "UT SOUTHWESTERN MEDICAL CENTER", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088970403", "display_name": "PPHF 2013: OSTLTS Partnerships- CBA of the Public Health System", "description": null, "funder_award_id": "5u38ot000169-03", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 180000.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U38", "start_date": "2013-07-01", "end_date": "2018-06-30", "start_year": 2013, "end_year": 2018, "landing_page_url": "https://reporter.nih.gov/project-details/8878081", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "EDWARD", "family_name": "TEPPORN", "orcid": null, "role_start": null, "affiliation": {"name": "ASIAN & PACIFIC ISLANDER AMER HLTH FORUM", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088971573", "display_name": "NURSE PRACTITIONER &NURSE MIDWIFERY PROGRAM", "description": null, "funder_award_id": "5d24nu000336-07", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": "D24", "start_date": "1997-03-01", "end_date": "1999-06-30", "start_year": 1997, "end_year": 1999, "landing_page_url": "https://reporter.nih.gov/project-details/2432183", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "GWENDOLYN V", "family_name": "SPEARS", "orcid": null, "role_start": null, "affiliation": {"name": "CHARLES R. DREW UNIVERSITY OF MED &SCI", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088972728", "display_name": "Hormonal regulation of mineral metabolism in fishes and invertebrates", "description": "The current proposal seeks to continue our long term program of studies on how calcium and phosphate homeostasis are regulated in fish and aquatic leeches by the peptide hormone, stanniocalcin-1 (STC-1).\r\r\n\r\r\n\r\r\n\r\r\nObjective I. The mitochondria-rich, chloride cells in trout gill have high levels of STC-1 receptors. We will explore the possibility that STC-1 is targeted to chloride cell mitochondria as part of the mechanism of action by which STC-1 inhibits gill calcium transport. \r\r\n\r\r\n\r\r\n\r\r\nObjective II. Early oocytes in trout ovary produce a variant form of STC-1 that appears to be targeted back to these oocytes in an autocrine or intracrine loop. We seek to identify the sub-cellular compartment targeted by the hormone and to purify the variant form of STC-1 for chemical analysis and bioassay.\r\r\n\r\r\n\r\r\n\r\r\nObjective #3. Leeches have STC-related proteins and receptors that regulate calcium uptake by the skin. We will study the regulation of this transport process by factors such as calcium. We will also determine if calcium uptake in leeches cyclical over time (weeks), as it is in fishes. We will also purify two different leech forms of STC, characterize then structurally and test them in biological studies.\r\r\n\r\r\n\r\r\n\r\r\n\r\r\n\r\r\n", "funder_award_id": "105644-2007", "funder": {"id": "https://openalex.org/F4320334593", "display_name": "Natural Sciences and Engineering Research Council of Canada", "doi": "10.13039/501100000038"}, "amount": 33107.0, "currency": "CAD", "funding_type": "research", "funder_scheme": "Discovery Grants Program - Individual", "start_date": "2009-04-01", "end_date": "2010-03-31", "start_year": 2009, "end_year": 2009, "landing_page_url": "https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=105644-2007", "doi": null, "provenance": "nserc_open_data", "lead_investigator": {"given_name": "Graham", "family_name": "Wagner", "orcid": null, "role_start": null, "affiliation": {"name": "University of Western Ontario", "country": "CANADA", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088975357", "display_name": "A National iPS Cell Network with Deep Phenotyping for Translational Research", "description": "Project Narrative This proposal creates a consortium of CTSAs with previously existing iPSC banks and expertise in their creation, culture, differentiation, and genetic manipulation with the goals of leveraging their collective resources and expertise to benefit the CSTA and greater research community. It further proposes the addition to the existing bank of ~2500 banked, reprogrammable blood samples from the second generation cohort of the Framingham Heart Study (FHS) as well as the additional banking of ~3700 blood samples from the Gen3 and Omni2 FHS cohorts. Together, these samples along with >1000 currently existing iPSC lines banked by participating CTSA sites will be catalogued and made available to all CTSAs along with a genome-editing “toolbox”, consisting of already-edited iPSC lines as well protocols and reagents to allow investigators to themselves edit the genomes of lines of their choosing. Finally, CTSAs participating in this proposal will establish and conduct an annual educational, hands-on iPSC culture course to provide essential training in iPSC culture and related techniques and thus maximize the potential utility of the CTSA iPSC bank and toolbox.", "funder_award_id": "3u01tr001810-03s1", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 266475.0, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U01", "start_date": "2016-09-15", "end_date": "2021-06-30", "start_year": 2016, "end_year": 2021, "landing_page_url": "https://reporter.nih.gov/project-details/9747426", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "CHAD ALBERT", "family_name": "COWAN", "orcid": null, "role_start": null, "affiliation": {"name": "BOSTON UNIVERSITY MEDICAL CAMPUS", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088975929", "display_name": "SBIR Phase I: Treatment of Perchlorate Contaminated Water Using Surface Engineered Super Paramagnetic Iron Oxide Nanoparticles", "description": "This SBIR Phase I project will develop an advanced state-of-the-art perchlorate remediation technology by using magnetic nanoparticles functionalized with selective perchlorate ion-receptors. Ion exchange, which is the most widely used technology for treating water containing less than 100ppb of perchlorate, has the drawback of needing frequest regeneration or disposal of the perchlorate-laden resins. This project will investigate the feasibility of using functionalized magnetic nanoparticles with certain specific anion receptors to selectively bind CIO4. \r\n\r\nThe broader/commercial impacts of the proposed project will be the removal of perchlorate contamination from drinking water sources. EPA estimates that about 90% of the perchlorate manufactured in the U.S. is used by the military or NASA. Perchlorate contamination has been detected in over 350 drinking water sources in California alone. Perchlorate cleanup in the U.S. is estimated to cost over $300 million. A cost-effective and environmentally acceptable technology could focus on some market share of the estimated $60 million market for perchlorate removal. \r\n", "funder_award_id": "0946115", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 149680.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Standard Grant", "start_date": "2010-01-01", "end_date": "2010-06-30", "start_year": 2010, "end_year": 2010, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0946115", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Adam", "family_name": "Stein", "orcid": null, "role_start": null, "affiliation": {"name": "Advantageous Systems LLC", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088976742", "display_name": "Information Assurance Scholarship Program", "description": "Carnegie Mellon leadership is extremely supportive of this program and believes strongly that SFS enables them to make a substantial contribution to the effort to secure the Federal Government's information infrastructure. The University desires to keep the number of students as close to current levels as possible, and is sharing the costs of the program to achieve that goal. The University contributes 25% of tuition costs per student, per year, a cost sharing that totals some $850,000 over the life of the grant and makes the cost per student proposal approximately $74,000, vs. approximately $87,000 in the original grant. SFS scholarships are awarded to students in either of two masters' degrees, the MS in Information Security Technology and Management, and the MS in Information Security Policy and Management. The curriculum for both programs have been certified pursuant to the Information Assurance Courseware Evaluation Process of the National Security Agency's National Infosec Training and Education Program, and have been mapped against NSTISSI No. 4011 - National Training Standard for Information Systems Security (INFOSEC) Professionals.", "funder_award_id": "0417007", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": 4113716.0, "currency": "USD", "funding_type": "grant", "funder_scheme": "Continuing Grant", "start_date": "2004-07-01", "end_date": "2010-06-30", "start_year": 2004, "end_year": 2010, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=0417007", "doi": null, "provenance": "nsf_award_search", "lead_investigator": {"given_name": "Donald", "family_name": "McGillen", "orcid": null, "role_start": null, "affiliation": {"name": "Carnegie Mellon University", "country": "", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088977150", "display_name": "RCMI Investigator Development Core", "description": null, "funder_award_id": "5u54md015946-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": null, "currency": "USD", "funding_type": "cooperative_agreement", "funder_scheme": "U54", "start_date": "2020-09-08", "end_date": "2025-04-30", "start_year": 2020, "end_year": 2025, "landing_page_url": "https://reporter.nih.gov/project-details/10644991", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "OLIVERA", "family_name": "NESIC-TAYLOR", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF HOUSTON", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088977576", "display_name": "Targeting Apolipoprotein E4-related Neuropathology", "description": null, "funder_award_id": "5r21ns046465-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 251460.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R21", "start_date": "2003-07-01", "end_date": "2006-06-30", "start_year": 2003, "end_year": 2006, "landing_page_url": "https://reporter.nih.gov/project-details/6752398", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ROBERT W.", "family_name": "MAHLEY", "orcid": null, "role_start": null, "affiliation": {"name": "J. DAVID GLADSTONE INSTITUTES", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088978287", "display_name": "Rites of Power: Symbolism, Ritual and Politics in the Soviet Union and Russia", "description": "In the last fifteen years, Russia has undergone major political change associated with the collapse of the USSR. One of the most important tasks of the new regime is to establish a sense of its legitimacy, which should in turn help to shape its future. As a major player in global politics and a significant power in the Asia-Pacific region, Russia's internal development has important consequences for Australia and the world. Only by understanding Russia and what is happening inside it can Australia adequately deal with and interact with it. This project will substantially further such understanding.", "funder_award_id": "DP0663764", "funder": {"id": "https://openalex.org/F4320334704", "display_name": "Australian Research Council", "doi": "10.13039/501100000923"}, "amount": 714343.0, "currency": "AUD", "funding_type": "research", "funder_scheme": "Discovery Projects", "start_date": "2006-01-01", "end_date": "2012-02-01", "start_year": 2006, "end_year": 2012, "landing_page_url": "https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663764", "doi": null, "provenance": "arc", "lead_investigator": {"given_name": "Graeme", "family_name": "Gill", "orcid": null, "role_start": null, "affiliation": {"name": "The University of Sydney", "country": "Australia", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088979205", "display_name": "Neuroimaging of Manganese Toxicity", "description": "PROJECT NARRATIVE Occupational exposure to manganese (Mn) through welding fumes continues to bear the risk of developing neurological impairments, with a safe exposure limit to airborne Mn being unknown. This study will define the dose-response relation of Mn deposition and elimination in the human brain, and investigate oxidative stress markers and neurotransmitter changes in a cohort of welders using personal air sampling and novel, non-invasive brain imaging techniques such as magnetic resonance imaging and spectroscopy. Understanding the spatial-temporal characteristics of human brain Mn deposition and neurochemical responses of the human brain will have significant translational impact on our understanding of the Mn dose-response relationship in welding, and will help defining a safe level of occupational exposure to Mn.", "funder_award_id": "5r01es032478-04", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 561236.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2021-04-07", "end_date": "2026-01-31", "start_year": 2021, "end_year": 2026, "landing_page_url": "https://reporter.nih.gov/project-details/10764954", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "ULRIKE", "family_name": "DYDAK", "orcid": null, "role_start": null, "affiliation": {"name": "PURDUE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088979567", "display_name": "Literary Neurodivergence Before Neurodiversity, or Neuroqueering French Literature from Stendhal to Wittig (1839-1984", "description": "What is a poetics of neurodivergence and what new and revealing light can it throw on key works of French-language literature? What can these works, in turn, tell us about neurodivergence? This thesis will draw on cutting-edge studies on neurodiversity to reimagine how we think about iconic literary texts and their real-world implications. It will offer, for the first time, neurodivergent and neuroqueer readings of canonical works of nineteenth- and twentieth-century French-language literature created before the emergence of the neurodiversity paradigm in the 1990s. Rather than 'diagnosing' characters or authors, this study will examine neurodivergent and neuroqueer 'resonances' in texts.", "funder_award_id": "2890273", "funder": {"id": "https://openalex.org/F4320334609", "display_name": "Arts and Humanities Research Council", "doi": "10.13039/501100000267"}, "amount": null, "currency": "GBP", "funding_type": "studentship", "funder_scheme": null, "start_date": "2023-09-30", "end_date": "2030-02-28", "start_year": 2023, "end_year": 2030, "landing_page_url": "https://gtr.ukri.org/projects?ref=2890273", "doi": null, "provenance": "gateway_to_research", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088981185", "display_name": "Uncovering the role of GPR75 as an activator of fatty acid transporters in non-alcoholic fatty liver disease (NAFLD)", "description": "This project addresses the NIH’s Illuminating the Druggable Genome (IDG) initiative by focusing on the poorly understood GPCR, GPR75 and its endogenous high-affinity ligand 20-HETE, a vasoactive lipid, in the context of obesity and non-alcoholic fatty liver disease (NAFLD). The proposed research will uncover the pathological consequences and molecular mechanisms that are activated by the paring of GPR75 to 20-HETE as well as how to best block this interaction in order to alleviate and prevent the damage associated with obesity and NAFLD. Obesity and obesity-associated complications like NAFLD are a major and ever-growing public health concern and our proposal will reveal how promising GPR75 is as a novel target for the treatment of these diseases.", "funder_award_id": "1r03tr004478-01", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 164000.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R03", "start_date": "2023-07-01", "end_date": "2024-12-31", "start_year": 2023, "end_year": 2024, "landing_page_url": "https://reporter.nih.gov/project-details/10666762", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "VICTOR", "family_name": "GARCIA", "orcid": null, "role_start": null, "affiliation": {"name": "NEW YORK MEDICAL COLLEGE", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088983816", "display_name": "Growth and toxin production of C. botulinum type E in packaged sea food with carbon dioxide-atmosphere", "description": "In order to establish a method for studying the growth and toxin production by Clostridium botulinum in modified atmosphere packaged (MAP) condition, agar surface system using Trypticase Soy Agar (TSA) plate in which the pH was adjusted to equal that in COィイD22ィエD2 atmospheres was employed. Results showed that this system could be used for estimating the effect of headspace gas on the bacterial growth (Escherichia coil and Staphylococcus aureus) on the surface of (TSA) packaged with various COィイD22ィエD2 partial pressures (0, 20, 40, 60, 80, 100%, balance NィイD22ィエD2).Using the agar surface system described above, the effect of COィイD22ィエD2 on spore germination and vegetative cell growth of Clostridinium botulinum was investigated at various concentration (COィイD22ィエD2 0-100%,remainder NィイD22ィエD2) and temperatures (15℃, 5℃). At 15℃, the number of spore which could germinate and outgrow was significantly enhanced under a controlled COィイD22ィエD2 gas atmosphere as compared to NィイD22ィエD2 gas atm…Moreosphere (100%) regardless of their concentrations. The highest number of germinating spore was obtained with COィイD22ィエD2 concentration of 20%, as followed by 40%, 60%, 80%, and 100% in this order. Storage at 5℃ under COィイD22ィエD2 atmosphere significantly reduced the number of spore which could germinate. Under NィイD22ィエD2 atmosphere the number of spore did not differ from initial levels and remained unchanged for remainder of the storage period. Hence it was suggested that COィイD22ィエD2 not only inhibit germination but also promote the death of C. botulinum type E at 5 or 0 ℃ on the agar media employed.These findings on the adverse effect of COィイD22ィエD2 on spore germination with decreasing temperatures suggest extreme importance of proper storage temperatures for controlled COィイD22ィエD2 MAP (Modified Atmosphere Packaged) foods at all point of the food chain.Finally, the growth and toxin production of Clostriclium botulinum type E inoculated on fresh fish fillets (jack mackerel and yellowtail) packaged under carbon dioxide (COィイD22ィエD2 40%, NィイD22ィエD2 60%) and NィイD22ィエD2(NィイD22ィエD2 100%) controlled gas atmosphere were investigated at two abusive temperatures (10℃, 30℃) for short period of time. At 10℃, the growth of C. botulunum was slower in samples initially packaged with 40% COィイD22ィエD2 than those packaged with 100% NィイD22ィエD2 in Jack Mckerel samples, indicating a potentially lower risk in COィイD22ィエD2 atmosphere than in NィイD22ィエD2 atmosphere at 10℃. No increase in the C. botulinum type E population on jack mackerel was noted regardless of the type of packaging within 6h at 30℃. At prolonged period of storage at 10℃, all samples were spoiled before they became toxic, regardless of atmospheres. The results suggested that the botulinal risk in MAP fish in Japanese distribution system is minimal even under abusive conditions.Less", "funder_award_id": "09660224", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 1000000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": null, "end_date": null, "start_year": null, "end_year": null, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09660224/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "Bon", "family_name": "KIMURA", "orcid": null, "role_start": null, "affiliation": {"name": "Tokyo University of Fisheries", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000050262340", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088985477", "display_name": "5HT AND MEK--INTERACTION OF VASCULAR TONE AND PRESSURE", "description": null, "funder_award_id": "5r29hl058489-05", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 119630.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R29", "start_date": "1998-09-01", "end_date": "2004-08-31", "start_year": 1998, "end_year": 2004, "landing_page_url": "https://reporter.nih.gov/project-details/6527118", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEPHANIE W", "family_name": "WATTS", "orcid": null, "role_start": null, "affiliation": {"name": "MICHIGAN STATE UNIVERSITY", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G40889878", "display_name": "RXRを分子標的としたジヒドロピリミジン誘導体の抗悪性腫瘍薬への基礎的研究", "description": "核内受容体であるレチノイドX受容体（RXR）をターゲットとしたRXRアゴニストは、がんをはじめ様々な疾病の治療に応用できると考えられているが、臨床上の副作用によりベキサロテン以外に臨床応用されていない。申請者は、新規合成ジヒドロピリミジン誘導体（DP）03がヒト骨髄系白血病細胞株NB4に惹起するアポトーシスをRXRアンタゴニスト共存下で阻害することを見出した。本研究では、DP03をDPに由来するRXRアゴニストとして抗悪性腫瘍薬とする臨床応用への有意義な基礎的知見を提供することを目指す。", "funder_award_id": "24K10458", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4680000.0, "currency": "JPY", "funding_type": "research", "funder_scheme": "Grant-in-Aid for Scientific Research (C)", "start_date": "2024-04-01", "end_date": "2027-03-31", "start_year": 2024, "end_year": 2027, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24K10458/", "doi": null, "provenance": "kaken", "lead_investigator": {"given_name": "秀与", "family_name": "菊地", "orcid": null, "role_start": null, "affiliation": {"name": "Josai University", "country": "Japan", "ids": [{"id": "https://nrid.nii.ac.jp/nrid/1000060614055", "type": "nrid", "asserted_by": "kaken"}]}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088988569", "display_name": "Copernicus Relays for digitalisation spanning a Network", "description": "CoRdiNet is an open network of five very diverse Copernicus Relays with a coordinating function on local, regional, cluster and national level, supporting, promoting and stimulating digitalisation and new business solutions based on Earth Observation (EO) i.e. Copernicus data. This coordination & support action bundles the local expertise in the civil use of EO, close to the needs and offers of citizens, administrations and businesses, and will share them with other Copernicus Relays, Academies and new EO players. Three Relays have a regional focus (Basilicata, Bavaria, East Midlands), one a national focus (Norway), while the fifth contributes the expertise of a space application company, GMV. NEREUS, the Network of European Regions using Space Technologies, comprises 26 regions and is active in exploiting the benefits of space technologies while supporting European regional space policies. As sixth partner it will be entrusted, supported by a yet to be set-up, evaluation board, to hold and decide on the distribution of a specific “fund” of 100 k EUR supporting more than 20 joint activities between the consortium and external partners with concrete proposals to collaborate. Coordination of CoRdiNet with both, the Copernicus FPA and the Copernicus Support Office, will be paid attention to. To offer tangible opportunities to collaborate with, the consortium will gather local expertise in sector oriented European-wide working groups to design better strategies and guidelines for new digital services, support the creation of pilot projects linking users & suppliers of services, organise awareness raising, bi-lateral events, while providing user-targeted information and find out about as well as bundle local key players and local societal challenges and needs, EO data are able to match. Joint outreach and dissemination activities ensure embedding of its work in national and EU/ESA activities. CoRdiNet enjoys support of EARSC, the FPA, the CSO, and 6 external regions.", "funder_award_id": "821911", "funder": {"id": "https://openalex.org/F4320320300", "display_name": "European Commission", "doi": "10.13039/501100000780"}, "amount": 999663.75, "currency": "EUR", "funding_type": "grant", "funder_scheme": "H2020 - CSA", "start_date": "2018-10-01", "end_date": "2020-12-31", "start_year": 2018, "end_year": 2020, "landing_page_url": "https://cordis.europa.eu/project/id/821911", "doi": "10.3030/821911", "provenance": "cordis", "lead_investigator": {"given_name": null, "family_name": null, "orcid": null, "role_start": null, "affiliation": {"name": "BAVAIRIA EV", "country": "DE", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088988937", "display_name": "ATOMIC AND MOLECULAR RECOMBINATION PROCESSES", "description": null, "funder_award_id": "7139486", "funder": {"id": "https://openalex.org/F4320306076", "display_name": "National Science Foundation", "doi": "10.13039/100000001"}, "amount": null, "currency": "USD", "funding_type": "grant", "funder_scheme": null, "start_date": "1971-01-01", "end_date": "1973-01-01", "start_year": 1971, "end_year": 1973, "landing_page_url": "https://www.nsf.gov/awardsearch/showAward?AWD_ID=7139486", "doi": null, "provenance": "nsf_award_search", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088988948", "display_name": "Culture-Based Prediction of Adolescent HIV Risk", "description": null, "funder_award_id": "5r01hd051438-02", "funder": {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "doi": "10.13039/100000002"}, "amount": 533710.0, "currency": "USD", "funding_type": "research", "funder_scheme": "R01", "start_date": "2007-08-15", "end_date": "2012-06-30", "start_year": 2007, "end_year": 2012, "landing_page_url": "https://reporter.nih.gov/project-details/7485231", "doi": null, "provenance": "nih_exporter", "lead_investigator": {"given_name": "STEPHEN L", "family_name": "EYRE", "orcid": null, "role_start": null, "affiliation": {"name": "UNIVERSITY OF CALIFORNIA, SAN FRANCISCO", "country": "UNITED STATES", "ids": null}}, "funded_outputs_count": 0} {"id": "https://openalex.org/G408899268", "display_name": "時間分解XAFS測定を用いた光触媒の構造・電子状態変化の追跡", "description": "本研究では半導体光触媒表面に担持した助触媒の、光励起した際の構造や電子状態の変化を可視化するために、時間分解型X線ビームステーションを用いた助触媒担持半導体光触媒への時間分解XAFS測定を行う。これにより光励起時の、助触媒の化学状態や構造状態の変化を観測する。", "funder_award_id": "22KJ3125", "funder": {"id": "https://openalex.org/F4320334764", "display_name": "Japan Society for the Promotion of Science", "doi": "10.13039/501100001691"}, "amount": 4420000.0, "currency": "JPY", "funding_type": "fellowship", "funder_scheme": "Grant-in-Aid for JSPS Fellows", "start_date": "2023-03-08", "end_date": "2024-03-31", "start_year": 2023, "end_year": 2024, "landing_page_url": "https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22KJ3125/", "doi": null, "provenance": "kaken", "lead_investigator": null, "funded_outputs_count": 0} {"id": "https://openalex.org/G4088993018", "display_name": "SessFor - Sustainable development of ecosystem services in Swiss forests", "description": "Background
The wood industry in Switzerland has great economic potential. The forest provides many more services than protection from avalanches and debris flows, recreation and biodiversity. Some services are provided simultaneously, others compete with each other. Megatrends such as climate change and energy transitions present new challenges to safeguarding the sustainability of these services. Today’s decision for one or the other service can have consequences for the next 50 to 100 years.
Aims
We aim to investigate the reactions of growth, mortality and regeneration to changing climate conditions and build the identified processes into the models. We will thus determine how synergies and conflicts in current forest services will change in future. In this connection it is important that, even if the forest’s multiple services are not safeguarded, they can nonetheless be fulfilled at the landscape level. This effect can be analysed using extrapolation of existing models to larger scales.
Importance
Together with forestry practitioners, sustainable forest management strategies are being defined for a variety of forest types. Using forest development models it will be possible to assess ecological and economic effects of the different forest management systems over long periods of time and for different scales. Insights from the study will be implemented in a prototype of an IT-based decision-making support system.