index,Instruction,molecule,logP
173028,Modify the molecule Cc1ccnc(N2CCC(c3nc(C(F)(F)F)c[nH]3)CC2)c1[N+](=O)[O-] to decrease its LogP value.,Cc1ccnc(N2CCC(c3nc(C(F)(F)F)c[nH]3)CC2)c1[N+](=O)[O-],3.424120000000002
114084,Please optimize the molecule CN(CC(=O)N1CCc2ccccc21)Cc1ccc(Cl)nc1 to have a lower LogP value.,CN(CC(=O)N1CCc2ccccc21)Cc1ccc(Cl)nc1,2.756100000000001
174437,Modify the molecule C[C@H]1CC(=O)N(CC(=O)NCc2ccc(F)cc2C(F)(F)F)C1=O to have a lower LogP value.,C[C@H]1CC(=O)N(CC(=O)NCc2ccc(F)cc2C(F)(F)F)C1=O,1.8556999999999997
1590,Please modify the molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 to decrease its LogP value.,C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1,4.574300000000004
132258,Please modify the molecule CCN(CC)C(=O)c1ccc(N[C@H]2CCN(C(C)C)C2=O)cc1Cl to decrease its LogP value.,CCN(CC)C(=O)c1ccc(N[C@H]2CCN(C(C)C)C2=O)cc1Cl,3.2432000000000016
239209,Optimize the molecule Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1 to have a lower LogP value.,Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1,-0.4344999999999968
93903,Modify the molecule O=C(NN1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O)c1cccc(Cl)c1 to decrease its LogP value.,O=C(NN1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O)c1cccc(Cl)c1,3.8770000000000033
216997,Please modify the molecule COc1cc(/C=C2/NC(=S)NC2=O)ccc1OC(=O)c1cccs1 to increase its LogP value.,COc1cc(/C=C2/NC(=S)NC2=O)ccc1OC(=O)c1cccs1,2.3211000000000004
187929,Modify the molecule CN(C)C(=O)Nc1cccc(C[NH2+]C(C2CC2)C2CC2)c1 to decrease its LogP value.,CN(C)C(=O)Nc1cccc(C[NH2+]C(C2CC2)C2CC2)c1,2.0321
194398,Modify the molecule CN(C)S(=O)(=O)c1cccc(NC(=O)[C@H]2CC(=O)N(c3cccc4ccccc34)C2)c1 to have a higher LogP value.,CN(C)S(=O)(=O)c1cccc(NC(=O)[C@H]2CC(=O)N(c3cccc4ccccc34)C2)c1,3.0817000000000014
76082,Modify the molecule Cc1nc(-c2ccc(C)c(-n3cc(C(=O)Nc4ccc(C)c(Cl)c4)c(C)n3)c2)no1 to increase its LogP value.,Cc1nc(-c2ccc(C)c(-n3cc(C(=O)Nc4ccc(C)c(Cl)c4)c(C)n3)c2)no1,5.061680000000004
216859,Please optimize the molecule Cc1cc(Cl)ccc1NC(=O)[C@H](C)Sc1nnc(C2CC2)s1 to have a lower LogP value.,Cc1cc(Cl)ccc1NC(=O)[C@H](C)Sc1nnc(C2CC2)s1,4.496620000000002
165426,Please optimize the molecule Cn1c(=O)cc(NCCCN2CCOCC2)n(Cc2ccc(F)cc2F)c1=O to have a lower LogP value.,Cn1c(=O)cc(NCCCN2CCOCC2)n(Cc2ccc(F)cc2F)c1=O,1.0077
74012,Modify the molecule COC(=O)C1C(C)=NC2=C(C(=O)CCC2)[C@@H]1c1ccc(OCc2ccccc2)c(OC)c1 to decrease its LogP value.,COC(=O)C1C(C)=NC2=C(C(=O)CCC2)[C@@H]1c1ccc(OCc2ccccc2)c(OC)c1,4.628600000000004
155172,Please modify the molecule CCc1cc(C(=O)NC[C@@H](c2ccc(OC)cc2)[NH+](C)C)sc1C to decrease its LogP value.,CCc1cc(C(=O)NC[C@@H](c2ccc(OC)cc2)[NH+](C)C)sc1C,2.2431200000000002
19530,Please modify the molecule CCOCCN(C)Cc1ccc(C)s1 to decrease its LogP value.,CCOCCN(C)Cc1ccc(C)s1,2.524820000000001
69042,Please modify the molecule Cc1[nH]c2ccc(F)cc2c1CC(=O)N[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,Cc1[nH]c2ccc(F)cc2c1CC(=O)N[C@H]1CCS(=O)(=O)C1,1.4612200000000002
76849,Modify the molecule N#C[C@@H](C(=O)CC[C@H]1CCCO1)c1ccc(F)cn1 to have a higher LogP value.,N#C[C@@H](C(=O)CC[C@H]1CCCO1)c1ccc(F)cn1,2.35618
117917,Please optimize the molecule CCN1C(=O)[C@H]2C=CC=C[C@@H]2NC1=S to have a lower LogP value.,CCN1C(=O)[C@H]2C=CC=C[C@@H]2NC1=S,0.8338000000000001
132789,Please modify the molecule O=C(c1cc(=O)[nH]c([O-])n1)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1 to increase its LogP value.,O=C(c1cc(=O)[nH]c([O-])n1)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1,0.7102999999999995
27899,Please modify the molecule CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)c1nc(-c2ccco2)sc1C to decrease its LogP value.,CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)c1nc(-c2ccco2)sc1C,3.5211200000000016
155737,Please modify the molecule Cc1nc(-c2csc(S(=O)(=O)N3CCC[C@@H](C(=O)NCCC(C)C)C3)c2)no1 to increase its LogP value.,Cc1nc(-c2csc(S(=O)(=O)N3CCC[C@@H](C(=O)NCCC(C)C)C3)c2)no1,2.6695200000000012
113239,Modify the molecule CCc1ccccc1-n1c(CCl)nc2c(CC)nn(C)c21 to increase its LogP value.,CCc1ccccc1-n1c(CCl)nc2c(CC)nn(C)c21,3.622600000000002
158685,Please modify the molecule CCC[C@@H](O)c1ccn(Cc2cncn2C(C)C)c1 to decrease its LogP value.,CCC[C@@H](O)c1ccn(Cc2cncn2C(C)C)c1,3.1473000000000013
226795,Optimize the molecule CCCn1nnc2cc(C(=O)Nc3cccc(SC)c3)ccc21 to have a higher LogP value.,CCCn1nnc2cc(C(=O)Nc3cccc(SC)c3)ccc21,3.815500000000002
46559,Modify the molecule O=C([C@@H]1CC(=O)N(C2CCCC2)C1)N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1 to have a higher LogP value.,O=C([C@@H]1CC(=O)N(C2CCCC2)C1)N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1,2.4004000000000003
210681,Modify the molecule O=C(NCCC(F)(F)F)Nc1ccc(F)cc1Br to have a lower LogP value.,O=C(NCCC(F)(F)F)Nc1ccc(F)cc1Br,3.6621000000000015
95720,Please optimize the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)Cc1ccc(C[NH3+])cc1 to have a lower LogP value.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)Cc1ccc(C[NH3+])cc1,-0.7509999999999952
30178,Optimize the molecule O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1O to have a lower LogP value.,O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1O,2.3445000000000005
12800,Modify the molecule Cc1c(C(=O)Nc2ccc3c(c2)COC3)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(C(=O)Nc2ccc3c(c2)COC3)cccc1[N+](=O)[O-],3.1857200000000017
72633,Please optimize the molecule CCCN1C(=O)C2(OCCCO2)c2cccc(C)c21 to have a higher LogP value.,CCCN1C(=O)C2(OCCCO2)c2cccc(C)c21,2.3413200000000005
157114,Modify the molecule C=C(C)[C@](C)(C#CC[NH+](CC)CC)OCCC#N to have a lower LogP value.,C=C(C)[C@](C)(C#CC[NH+](CC)CC)OCCC#N,1.1795799999999999
84790,Optimize the molecule C[C@H](CC(=O)N(C)Cc1nccs1)NC(=O)c1ccccc1 to have a lower LogP value.,C[C@H](CC(=O)N(C)Cc1nccs1)NC(=O)c1ccccc1,2.3101000000000003
76597,Please modify the molecule CCC(CC)N1C(=O)[C@@H](C(C)(C)C)NC(=O)[C@H]1[C@H](C)CC to decrease its LogP value.,CCC(CC)N1C(=O)[C@@H](C(C)(C)C)NC(=O)[C@H]1[C@H](C)CC,2.9628000000000014
197149,Please optimize the molecule NS(=O)(=O)c1ccc(CCNc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(CCNc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1,2.9156000000000004
69426,Modify the molecule CC[C@@H]1COCCN1Cc1ccccc1OCc1cccnc1 to decrease its LogP value.,CC[C@@H]1COCCN1Cc1ccccc1OCc1cccnc1,3.2714000000000016
153633,Modify the molecule C[C@@H]1CCCCN1C(=O)Cn1cnc2onc(-c3ccc(Cl)cc3)c2c1=O to decrease its LogP value.,C[C@@H]1CCCCN1C(=O)Cn1cnc2onc(-c3ccc(Cl)cc3)c2c1=O,3.105900000000002
159707,Modify the molecule COc1ccc(-c2cc(=O)[nH]c(N3CC[NH+](Cc4ccccc4)CC3)n2)cc1 to increase its LogP value.,COc1ccc(-c2cc(=O)[nH]c(N3CC[NH+](Cc4ccccc4)CC3)n2)cc1,1.3505999999999996
15428,Modify the molecule COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCCCC3)c2)c1 to decrease its LogP value.,COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCCCC3)c2)c1,3.1221000000000014
188946,Please optimize the molecule CCC(C)(C)NC(=O)c1ccc(NCC(=O)OC)cc1Cl to have a higher LogP value.,CCC(C)(C)NC(=O)c1ccc(NCC(=O)OC)cc1Cl,2.843300000000001
52481,Please optimize the molecule Cc1ccn2/c(=N/C(=O)[C@@H]3CC=CCC3)[nH]nc2c1 to have a higher LogP value.,Cc1ccn2/c(=N/C(=O)[C@@H]3CC=CCC3)[nH]nc2c1,1.7544199999999999
43828,Modify the molecule O=C(CNC(=O)C1CC1)NC1=NN=C(C2=CC[C@@H](Br)S2)C1 to have a higher LogP value.,O=C(CNC(=O)C1CC1)NC1=NN=C(C2=CC[C@@H](Br)S2)C1,1.528800000000001
109661,Modify the molecule O=C(CN1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccco1)NC1CCCC1 to have a lower LogP value.,O=C(CN1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccco1)NC1CCCC1,4.318700000000003
132673,Please optimize the molecule O=C(Cc1ccc(Cl)cc1)NCc1csc(C2CC2)n1 to have a lower LogP value.,O=C(Cc1ccc(Cl)cc1)NCc1csc(C2CC2)n1,3.5328000000000017
36559,Optimize the molecule O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1,4.566400000000004
7934,Please modify the molecule CCN(C)S(=O)(=O)c1c(C)nn(Cc2ccc(C(F)(F)F)cc2)c1C to increase its LogP value.,CCN(C)S(=O)(=O)c1c(C)nn(Cc2ccc(C(F)(F)F)cc2)c1C,3.207440000000002
83410,Modify the molecule Cc1nc(C2CCCC2)sc1/C([O-])=C(\C#N)C(=O)NC1CCCC1 to decrease its LogP value.,Cc1nc(C2CCCC2)sc1/C([O-])=C(\C#N)C(=O)NC1CCCC1,2.762900000000001
177930,Modify the molecule CCC[NH2+]C/C(=C\[C@H](C)CC)CC to increase its LogP value.,CCC[NH2+]C/C(=C\[C@H](C)CC)CC,2.3423
85925,Modify the molecule COc1cccc(NC(=O)CNc2cc(Cl)cc(Cl)c2)c1 to decrease its LogP value.,COc1cccc(NC(=O)CNc2cc(Cl)cc(Cl)c2)c1,4.052600000000002
10112,Please modify the molecule CCc1c(C(=O)N2CCN(S(=O)(=O)N(C)C)CC2)cnn1-c1ccc(F)cc1 to increase its LogP value.,CCc1c(C(=O)N2CCN(S(=O)(=O)N(C)C)CC2)cnn1-c1ccc(F)cc1,1.1380000000000003
146889,Modify the molecule Brc1ccc(C[NH2+]Cc2ccccc2CN2CCOCC2)cc1 to have a lower LogP value.,Brc1ccc(C[NH2+]Cc2ccccc2CN2CCOCC2)cc1,2.544900000000001
184583,Modify the molecule COc1ccc([C@H](O)CNC(=O)N[C@H]2CCCc3ccc(F)cc32)cc1 to have a higher LogP value.,COc1ccc([C@H](O)CNC(=O)N[C@H]2CCCc3ccc(F)cc32)cc1,3.244500000000002
83621,Please optimize the molecule C#CCOc1ccc(NC(=O)[C@H]2CCCN(C(=O)NCC(C)C)C2)cc1 to have a higher LogP value.,C#CCOc1ccc(NC(=O)[C@H]2CCCN(C(=O)NCC(C)C)C2)cc1,2.7147000000000006
49007,Modify the molecule Cc1cccc([C@@H]2CCCN2C(=O)Nc2cccnc2Cl)c1 to have a higher LogP value.,Cc1cccc([C@@H]2CCCN2C(=O)Nc2cccnc2Cl)c1,4.412420000000003
14594,Please modify the molecule CC(C)[C@H](NC(=O)[C@H]1CS[C@H]2c3ccccc3C(=O)N12)C(=O)NC1CCCCCC1 to decrease its LogP value.,CC(C)[C@H](NC(=O)[C@H]1CS[C@H]2c3ccccc3C(=O)N12)C(=O)NC1CCCCCC1,3.236200000000001
61201,Modify the molecule C[C@H](CC#N)N(C)C(=O)N1Cc2[nH+]c[nH]c2C[C@@H]1C(=O)[O-] to decrease its LogP value.,C[C@H](CC#N)N(C)C(=O)N1Cc2[nH+]c[nH]c2C[C@@H]1C(=O)[O-],-1.3406199999999986
182698,Please optimize the molecule C[C@@H](CCl)CS(=O)(=O)N[C@H](C)c1ccccc1F to have a lower LogP value.,C[C@@H](CCl)CS(=O)(=O)N[C@H](C)c1ccccc1F,2.681000000000001
85862,Please modify the molecule CCNC(=O)N1C[C@@H](C)C[C@@H]([NH3+])C1 to decrease its LogP value.,CCNC(=O)N1C[C@@H](C)C[C@@H]([NH3+])C1,-0.33179999999999876
172136,Modify the molecule Cc1cc(-c2nn3c(-c4cc(Cl)cc(Cl)c4)nnc3s2)on1 to have a lower LogP value.,Cc1cc(-c2nn3c(-c4cc(Cl)cc(Cl)c4)nnc3s2)on1,4.123020000000001
56168,Modify the molecule COc1ccc([C@@H]2N=N/C(=[NH+]/C(=O)Nc3ccccc3)S2)cc1 to decrease its LogP value.,COc1ccc([C@@H]2N=N/C(=[NH+]/C(=O)Nc3ccccc3)S2)cc1,2.5615000000000006
3826,Please modify the molecule COc1ccc(F)cc1NC(=O)C(=O)NCc1cc(Br)cs1 to decrease its LogP value.,COc1ccc(F)cc1NC(=O)C(=O)NCc1cc(Br)cs1,2.9132000000000007
148861,Modify the molecule Cc1ccc(CN2C(=O)c3ccccc3[C@@H]2c2c(C)n(C)c3ccccc23)o1 to decrease its LogP value.,Cc1ccc(CN2C(=O)c3ccccc3[C@@H]2c2c(C)n(C)c3ccccc23)o1,5.133540000000004
38172,Modify the molecule CN(CC1CC[NH+](C)CC1)C(=O)c1ccc(F)c(Br)c1 to increase its LogP value.,CN(CC1CC[NH+](C)CC1)C(=O)c1ccc(F)c(Br)c1,1.5849
142010,Modify the molecule Cc1ccc2oc(=O)c(CC(=O)c3ccc(F)cc3)nc2c1 to have a lower LogP value.,Cc1ccc2oc(=O)c(CC(=O)c3ccc(F)cc3)nc2c1,3.060920000000001
235798,Optimize the molecule C[C@@H](NC(=O)[C@@H]1C[C@@H]1c1ccccc1Br)c1cccnc1 to have a higher LogP value.,C[C@@H](NC(=O)[C@@H]1C[C@@H]1c1ccccc1Br)c1cccnc1,3.825000000000003
36338,Please optimize the molecule Cc1cccc(Oc2ccc(NC(=O)C(=O)N[C@H](C)CO)cc2)c1 to have a higher LogP value.,Cc1cccc(Oc2ccc(NC(=O)C(=O)N[C@H](C)CO)cc2)c1,2.2228199999999996
138761,Optimize the molecule NC(=O)[C@@H]1CCC[NH+]1[C@@H](C(=O)[O-])c1c[nH]c2cc(OCc3ccccc3)ccc12 to have a lower LogP value.,NC(=O)[C@@H]1CCC[NH+]1[C@@H](C(=O)[O-])c1c[nH]c2cc(OCc3ccccc3)ccc12,0.07050000000000223
168906,Please optimize the molecule NC(=O)[C@@H](c1cccc(Cl)c1)c1ncc(C(F)(F)F)cc1Cl to have a higher LogP value.,NC(=O)[C@@H](c1cccc(Cl)c1)c1ncc(C(F)(F)F)cc1Cl,4.024400000000001
211566,Please optimize the molecule Cc1nc2n(n1)CCC[C@H]2[NH2+][C@@H]1CCC[C@@H]1c1ccc(F)cc1 to have a higher LogP value.,Cc1nc2n(n1)CCC[C@H]2[NH2+][C@@H]1CCC[C@@H]1c1ccc(F)cc1,2.4602200000000005
66837,Please modify the molecule Cc1ccc(C(=O)N2CCC[C@H](C(=O)NCc3nnc4n3CCC4)C2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)N2CCC[C@H](C(=O)NCc3nnc4n3CCC4)C2)cc1,1.701319999999999
108069,Modify the molecule Oc1ccccc1C1OCCO1 to have a lower LogP value.,Oc1ccccc1C1OCCO1,1.4376
173284,Modify the molecule CN1CCC([NH+](C)CCN(C)CC(=O)N[C@@H]2CCOc3ccccc32)CC1 to decrease its LogP value.,CN1CCC([NH+](C)CCN(C)CC(=O)N[C@@H]2CCOc3ccccc32)CC1,0.1671000000000049
519,Modify the molecule COc1ccc(Cn2ccc3nc(N4CCN(c5ccccc5)CC4)ncc3c2=O)cc1 to have a higher LogP value.,COc1ccc(Cn2ccc3nc(N4CCN(c5ccccc5)CC4)ncc3c2=O)cc1,3.1750000000000016
217295,Optimize the molecule C=CC(=O)Nc1cc(NC(=O)c2cn(C)nc2CC)ccc1F to have a lower LogP value.,C=CC(=O)Nc1cc(NC(=O)c2cn(C)nc2CC)ccc1F,2.4984
11948,Please modify the molecule CCN(C(=O)[C@H]1[C@H](C=C(C)C)C1(C)C)[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,CCN(C(=O)[C@H]1[C@H](C=C(C)C)C1(C)C)[C@H]1CCS(=O)(=O)C1,2.2604000000000006
141684,Please modify the molecule C[NH+]1CCN(C(=O)CC2CCN(c3ncnc4nc(N)ccc34)CC2)CC1 to decrease its LogP value.,C[NH+]1CCN(C(=O)CC2CCN(c3ncnc4nc(N)ccc34)CC2)CC1,-0.42959999999999576
196283,Optimize the molecule CCn1nc(C(=O)NCCc2ccc(C)o2)c(=O)c2cc(F)ccc21 to have a lower LogP value.,CCn1nc(C(=O)NCCc2ccc(C)o2)c(=O)c2cc(F)ccc21,2.4294200000000004
94315,Optimize the molecule Cc1cccc([C@@H]2CCCN2C(=O)NCc2nnc3n2CCC3)c1C to have a higher LogP value.,Cc1cccc([C@@H]2CCCN2C(=O)NCc2nnc3n2CCC3)c1C,2.8878400000000015
121725,Modify the molecule CC[C@H](C)NC(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1C to increase its LogP value.,CC[C@H](C)NC(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1C,3.089620000000002
155064,Modify the molecule O=C(c1cccs1)C(O)O to have a lower LogP value.,O=C(c1cccs1)C(O)O,0.24149999999999988
28743,Please modify the molecule COC(=O)c1occc1CSc1nnc2sc3ccccc3n12 to increase its LogP value.,COC(=O)c1occc1CSc1nnc2sc3ccccc3n12,3.6159000000000026
239413,Please modify the molecule Cc1cc(C)c2c(c1)=[NH+][C@@H](C(=O)NCc1ccccc1)C=2 to decrease its LogP value.,Cc1cc(C)c2c(c1)=[NH+][C@@H](C(=O)NCc1ccccc1)C=2,-0.5172599999999961
78468,Please optimize the molecule O=C(Cl)C1=Cc2ccccc2CC1=O to have a higher LogP value.,O=C(Cl)C1=Cc2ccccc2CC1=O,1.9605999999999995
44848,Please optimize the molecule Cc1ccsc1C[NH2+][C@@H]1CCC[C@H](C(F)(F)F)C1 to have a lower LogP value.,Cc1ccsc1C[NH2+][C@@H]1CCC[C@H](C(F)(F)F)C1,3.2410200000000016
244953,Please modify the molecule N#C/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2s1 to decrease its LogP value.,N#C/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2s1,5.013880000000003
171162,Please optimize the molecule CC1=[NH+]C(=S)[C@H]([N+](=O)[O-])N1 to have a lower LogP value.,CC1=[NH+]C(=S)[C@H]([N+](=O)[O-])N1,-1.9811999999999994
170742,Please optimize the molecule O=C(/C=C/c1cccs1)N1CCCSC[C@@H]1C[NH+]1CCCCC1 to have a higher LogP value.,O=C(/C=C/c1cccs1)N1CCCSC[C@@H]1C[NH+]1CCCCC1,2.1642
38247,Modify the molecule CC[C@](C)(CCO)NC(=O)N[C@H]1CCCC[C@@H]1OC1CCCC1 to increase its LogP value.,CC[C@](C)(CCO)NC(=O)N[C@H]1CCCC[C@@H]1OC1CCCC1,3.1071000000000017
87473,Modify the molecule Cc1cc(C)cc(N(C)CC2(CO)COC2)c1 to have a lower LogP value.,Cc1cc(C)cc(N(C)CC2(CO)COC2)c1,1.7485399999999998
152234,Modify the molecule O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)c1cccc(NC(=O)[C@@H]2CCCO2)c1 to decrease its LogP value.,O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)c1cccc(NC(=O)[C@@H]2CCCO2)c1,2.015399999999999
101254,Please modify the molecule COC1CCN(C(=O)NCCC2=CCCCC2)CC1 to decrease its LogP value.,COC1CCN(C(=O)NCCC2=CCCCC2)CC1,2.697300000000001
46806,Modify the molecule CCS(=O)(=O)CCN(C)C(=O)[C@H](C)Oc1ccc(Cl)c(Cl)c1 to have a higher LogP value.,CCS(=O)(=O)CCN(C)C(=O)[C@H](C)Oc1ccc(Cl)c(Cl)c1,2.6538000000000013
41480,Please optimize the molecule CC(C)c1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1 to have a higher LogP value.,CC(C)c1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1,4.502800000000003
112425,Please modify the molecule C[C@H]1[NH2+]CC[C@@H]1C(=O)NC12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,C[C@H]1[NH2+]CC[C@@H]1C(=O)NC12CC3CC(CC(C3)C1)C2,1.0431999999999997
115725,Optimize the molecule CN(Cc1nc(C(F)(F)F)cs1)C(=O)c1ccccc1Cl to have a higher LogP value.,CN(Cc1nc(C(F)(F)F)cs1)C(=O)c1ccccc1Cl,4.087500000000002
136001,Modify the molecule Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NCCC[NH+]3CCCC3)CC2)c(C)c1C to increase its LogP value.,Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NCCC[NH+]3CCCC3)CC2)c(C)c1C,1.8144000000000018
164609,Optimize the molecule NC(=O)[C@@H]1[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]2[C@H]2c3ccccc3C=CN21 to have a higher LogP value.,NC(=O)[C@@H]1[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]2[C@H]2c3ccccc3C=CN21,1.6828999999999994
90795,Optimize the molecule COCCN(Cc1cccnc1)C(=O)N[C@@H]1C[C@@H]1C1CCCCC1 to have a lower LogP value.,COCCN(Cc1cccnc1)C(=O)N[C@@H]1C[C@@H]1C1CCCCC1,3.208400000000002
1727,Modify the molecule C[C@@H]1C[C@H]1C(=O)N1CCC(O)(Cn2cnc3cc(Cl)ccc3c2=O)CC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCC(O)(Cn2cnc3cc(Cl)ccc3c2=O)CC1,2.0593999999999992
192758,Optimize the molecule Cc1cc(C)n(-c2ccccc2NC(=O)N(C)[C@@H](C)CS(C)(=O)=O)n1 to have a lower LogP value.,Cc1cc(C)n(-c2ccccc2NC(=O)N(C)[C@@H](C)CS(C)(=O)=O)n1,2.3859400000000006
74529,Please modify the molecule [NH3+][C@@H]1CCC[C@H]1CCN1CCCC1=O to decrease its LogP value.,[NH3+][C@@H]1CCC[C@H]1CCN1CCCC1=O,0.40949999999999953
174278,Please modify the molecule Cc1cc(NC[C@@H]2COCCO2)ccc1[N+](=O)[O-] to increase its LogP value.,Cc1cc(NC[C@@H]2COCCO2)ccc1[N+](=O)[O-],1.7305199999999998
87273,Please modify the molecule CNC(=O)C[NH2+]Cc1ccc(OC)cc1 to increase its LogP value.,CNC(=O)C[NH2+]Cc1ccc(OC)cc1,-0.4953999999999985
122367,Modify the molecule COc1cc(-c2nnc3s/c(=C/c4ccc(Cl)cc4)c(=O)n23)cc(OC)c1OC to have a lower LogP value.,COc1cc(-c2nnc3s/c(=C/c4ccc(Cl)cc4)c(=O)n23)cc(OC)c1OC,3.044900000000002
173940,Modify the molecule CN(C)C(=O)c1cc([C@@H]2CCN(C(=O)c3ccccc3-c3ccccc3)C2)nc2ccccc12 to have a higher LogP value.,CN(C)C(=O)c1cc([C@@H]2CCN(C(=O)c3ccccc3-c3ccccc3)C2)nc2ccccc12,5.233300000000005
91542,Modify the molecule COc1ccc(OC)c(C[NH2+]Cc2cc(OC)c3c(c2)OCCO3)c1 to increase its LogP value.,COc1ccc(OC)c(C[NH2+]Cc2cc(OC)c3c(c2)OCCO3)c1,1.7471999999999994
24073,Modify the molecule Cc1ccc(Cn2cc(C(=O)c3ccc(F)cc3)c(=O)c3cc(F)ccc32)cc1 to have a higher LogP value.,Cc1ccc(Cn2cc(C(=O)c3ccc(F)cc3)c(=O)c3cc(F)ccc32)cc1,4.867420000000004
70628,Modify the molecule CC[C@](C)(CO)Nc1nc2ccc(F)cn2n1 to increase its LogP value.,CC[C@](C)(CO)Nc1nc2ccc(F)cn2n1,1.4412999999999996
118864,Please optimize the molecule Cc1ccccc1NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C to have a higher LogP value.,Cc1ccccc1NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C,2.2407200000000005
103102,Please modify the molecule Cc1n[nH]cc1C(=O)NNC(=O)C[NH+]1CCC[C@H]1C to decrease its LogP value.,Cc1n[nH]cc1C(=O)NNC(=O)C[NH+]1CCC[C@H]1C,-1.4536799999999979
130107,Optimize the molecule C[C@H](c1ccc(F)cc1)n1c(Cn2ncc3ccccc3c2=O)n[nH]c1=S to have a lower LogP value.,C[C@H](c1ccc(F)cc1)n1c(Cn2ncc3ccccc3c2=O)n[nH]c1=S,3.4472900000000015
53730,Please modify the molecule COc1ccc2c(C)nc(N(C)CC[NH+]3CCCC[C@@H]3C)nc2c1 to increase its LogP value.,COc1ccc2c(C)nc(N(C)CC[NH+]3CCCC[C@@H]3C)nc2c1,1.8403199999999995
237683,Optimize the molecule CN(Cc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)c1ccccn1 to have a higher LogP value.,CN(Cc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)c1ccccn1,1.7397999999999998
26686,Modify the molecule C[C@@H]1CCCC[C@H]1NC(=O)C(=O)Nc1nnc(-c2cccc(Cl)c2)s1 to decrease its LogP value.,C[C@@H]1CCCC[C@H]1NC(=O)C(=O)Nc1nnc(-c2cccc(Cl)c2)s1,3.491900000000001
245174,Please optimize the molecule CC[C@@]1(COC)CC(=O)NC(=O)[C@@H]1CC(C)C to have a lower LogP value.,CC[C@@]1(COC)CC(=O)NC(=O)[C@@H]1CC(C)C,1.7379999999999995
125458,Modify the molecule CC[NH+]1CCC[C@H]1CN(C)c1ccc(C(C)=O)cc1F to decrease its LogP value.,CC[NH+]1CCC[C@H]1CN(C)c1ccc(C(C)=O)cc1F,1.5317000000000005
123474,Optimize the molecule CC[NH2+]Cc1cccc2c1ccn2C[C@H]1CN(C)CCO1 to have a lower LogP value.,CC[NH2+]Cc1cccc2c1ccn2C[C@H]1CN(C)CCO1,1.0551999999999997
134028,Optimize the molecule [NH3+]CC[C@@H]1CCC[NH+](Cc2ccc(C3CC3)cc2)C1 to have a lower LogP value.,[NH3+]CC[C@@H]1CCC[NH+](Cc2ccc(C3CC3)cc2)C1,0.9909000000000001
161393,Modify the molecule O=C(NCCNC(=O)C1CC1)NCc1ccc(C(F)(F)F)cc1 to increase its LogP value.,O=C(NCCNC(=O)C1CC1)NCc1ccc(C(F)(F)F)cc1,2.0308
116515,Modify the molecule COc1ccc(Nc2cc(N)nc(-c3ccc(F)cc3)n2)c(OC)c1 to have a higher LogP value.,COc1ccc(Nc2cc(N)nc(-c3ccc(F)cc3)n2)c(OC)c1,3.625700000000001
139944,Modify the molecule CCn1ncc(C2=NS(=O)(=O)N(C)C(C(=O)Nc3ccc(C)c(C)c3)=C2)c1C to decrease its LogP value.,CCn1ncc(C2=NS(=O)(=O)N(C)C(C(=O)Nc3ccc(C)c(C)c3)=C2)c1C,2.3301600000000002
19664,Modify the molecule Cc1ccc(NC(=O)c2cn(C)nc2S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(NC(=O)c2cn(C)nc2S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)cc1,3.145120000000002
171544,Modify the molecule CCOCCC(=O)NCc1sccc1CC to increase its LogP value.,CCOCCC(=O)NCc1sccc1CC,2.3533
222813,Modify the molecule C=CCNc1oc(-c2ccccc2OC)nc1S(=O)(=O)c1ccc2c(c1)OCCO2 to have a higher LogP value.,C=CCNc1oc(-c2ccccc2OC)nc1S(=O)(=O)c1ccc2c(c1)OCCO2,3.552100000000002
142218,Optimize the molecule COc1ncc(Cl)c(NCc2cccc(-c3nc[nH]n3)c2)n1 to have a higher LogP value.,COc1ncc(Cl)c(NCc2cccc(-c3nc[nH]n3)c2)n1,2.5358
89641,Please modify the molecule CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O to increase its LogP value.,CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O,1.794
187362,Modify the molecule C[C@@H]([NH3+])c1cc(F)ccc1SC[C@@H](O)CO to have a lower LogP value.,C[C@@H]([NH3+])c1cc(F)ccc1SC[C@@H](O)CO,0.5739000000000003
104952,Please modify the molecule COc1ccc(Br)c(C(=O)N2CCN(C)c3nc4ccccc4nc32)c1 to increase its LogP value.,COc1ccc(Br)c(C(=O)N2CCN(C)c3nc4ccccc4nc32)c1,3.4975000000000023
68902,Please optimize the molecule O=C(NOCCc1ccccc1)Nc1ccc([N+](=O)[O-])cc1 to have a lower LogP value.,O=C(NOCCc1ccccc1)Nc1ccc([N+](=O)[O-])cc1,2.890600000000001
160275,Modify the molecule CN(C)C(=O)c1ccccc1NC(=S)NC(=O)C1CCCCC1 to decrease its LogP value.,CN(C)C(=O)c1ccccc1NC(=S)NC(=O)C1CCCCC1,2.7817000000000016
221169,Please modify the molecule Cc1cc(Cl)ccc1NC(=O)c1ccc(Br)cc1N to increase its LogP value.,Cc1cc(Cl)ccc1NC(=O)c1ccc(Br)cc1N,4.245420000000002
85113,Modify the molecule Cc1ccc(-n2c(S[C@@H]3CCOC3=O)nc3ccccc3c2=O)cc1F to have a lower LogP value.,Cc1ccc(-n2c(S[C@@H]3CCOC3=O)nc3ccccc3c2=O)cc1F,3.240820000000002
69329,Please optimize the molecule CC[NH2+]Cc1cnn(-c2ccc(Cl)c(F)c2)c1C(F)(F)F to have a higher LogP value.,CC[NH2+]Cc1cnn(-c2ccc(Cl)c(F)c2)c1C(F)(F)F,2.7669000000000015
132129,Modify the molecule C[C@H](C(=O)NC1C(C)(C)C1(C)C)N1CC[NH2+]CC1 to decrease its LogP value.,C[C@H](C(=O)NC1C(C)(C)C1(C)C)N1CC[NH2+]CC1,-0.1952999999999978
199584,Modify the molecule CCC[C@H]1C[C@H]1NC(=O)Cn1cnc2ccc(Br)cc2c1=O to have a lower LogP value.,CCC[C@H]1C[C@H]1NC(=O)Cn1cnc2ccc(Br)cc2c1=O,2.4638
130740,Modify the molecule Cc1cccc(-n2nnnc2S[C@@H](C)C(=O)N2CCCC2)c1 to increase its LogP value.,Cc1cccc(-n2nnnc2S[C@@H](C)C(=O)N2CCCC2)c1,2.07372
209061,Optimize the molecule O=C(Cn1nc(-c2ccco2)c2sc(N3CCCCC3)nc2c1=O)c1ccccc1 to have a lower LogP value.,O=C(Cn1nc(-c2ccco2)c2sc(N3CCCCC3)nc2c1=O)c1ccccc1,3.986200000000003
11477,Optimize the molecule C[NH+](C)CCN(Cc1cccnc1)C(=O)c1cc2cccc(Cl)c2o1 to have a higher LogP value.,C[NH+](C)CCN(Cc1cccnc1)C(=O)c1cc2cccc(Cl)c2o1,2.2681000000000004
64251,Please optimize the molecule O=C(N[C@H]1CCCc2occc21)c1ccc(-c2ccccc2)[nH]c1=O to have a lower LogP value.,O=C(N[C@H]1CCCc2occc21)c1ccc(-c2ccccc2)[nH]c1=O,3.4423000000000012
198010,Modify the molecule N#Cc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccccc21 to have a lower LogP value.,N#Cc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccccc21,2.799380000000001
3023,Please modify the molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 to increase its LogP value.,O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2,2.2076000000000002
80473,Optimize the molecule C[C@H]1CN(C(=O)c2cccc3c2O[C@H](C)C(=O)N3)C[C@H]1[NH+](C)C to have a lower LogP value.,C[C@H]1CN(C(=O)c2cccc3c2O[C@H](C)C(=O)N3)C[C@H]1[NH+](C)C,0.011000000000001675
218854,Please modify the molecule O=C1CN2CSC[C@H]2C(=O)N1Cc1ccccc1 to increase its LogP value.,O=C1CN2CSC[C@H]2C(=O)N1Cc1ccccc1,0.9302999999999999
153692,Modify the molecule Cc1ccc([C@H](C)NC(=O)c2cc3ccccc3oc2=O)cc1C to decrease its LogP value.,Cc1ccc([C@H](C)NC(=O)c2cc3ccccc3oc2=O)cc1C,3.9008400000000023
189765,Modify the molecule CON(C)C(=O)c1ccc(NC(=O)[C@H]2CCCS2)cc1 to have a lower LogP value.,CON(C)C(=O)c1ccc(NC(=O)[C@H]2CCCS2)cc1,2.1540999999999997
83123,Please modify the molecule CCc1cc(=O)n(CC(=O)Nc2cc(F)ccc2F)c(N2CCOCC2)n1 to increase its LogP value.,CCc1cc(=O)n(CC(=O)Nc2cc(F)ccc2F)c(N2CCOCC2)n1,1.5592000000000001
109466,Modify the molecule CC(C)n1ncc2cc(C(=O)NCCNC(=O)c3ccco3)cnc21 to have a higher LogP value.,CC(C)n1ncc2cc(C(=O)NCCNC(=O)c3ccco3)cnc21,1.765
71399,Please modify the molecule CC[NH+](Cc1ccccc1N1CCN(C(C)=O)CC1)[C@@H](C)c1ccc(F)cc1 to decrease its LogP value.,CC[NH+](Cc1ccccc1N1CCN(C(C)=O)CC1)[C@@H](C)c1ccc(F)cc1,2.6602000000000006
244192,Optimize the molecule O=C(c1ccc(Cl)cc1)C1CC[NH+](Cc2ccccn2)CC1 to have a lower LogP value.,O=C(c1ccc(Cl)cc1)C1CC[NH+](Cc2ccccn2)CC1,2.4128000000000007
76569,Please optimize the molecule COc1ccc(N)c2nc(C)c(C)nc12 to have a higher LogP value.,COc1ccc(N)c2nc(C)c(C)nc12,1.8374399999999997
199837,Optimize the molecule CC1=C2C(=O)N=C(CS[C@H](C)C(=O)NCc3ccc4c(c3)OCCO4)N=C2S[C@@H]1C to have a lower LogP value.,CC1=C2C(=O)N=C(CS[C@H](C)C(=O)NCc3ccc4c(c3)OCCO4)N=C2S[C@@H]1C,2.984700000000002
117533,Please modify the molecule CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)Nc1ccc4ccccc4n1)(C3)C2 to increase its LogP value.,CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)Nc1ccc4ccccc4n1)(C3)C2,3.6484000000000023
234161,Please modify the molecule CCS(=O)(=O)[N-]c1ccc([C@@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)cc1 to increase its LogP value.,CCS(=O)(=O)[N-]c1ccc([C@@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)cc1,1.2866999999999997
194016,Please optimize the molecule COc1ccc([C@H](Cl)[C@]2(C)CCCO2)c(Br)c1 to have a lower LogP value.,COc1ccc([C@H](Cl)[C@]2(C)CCCO2)c(Br)c1,4.306700000000003
48187,Modify the molecule Cc1nc2ccc3nc(NC(=O)CN4C(=O)CCC4=O)sc3c2s1 to have a higher LogP value.,Cc1nc2ccc3nc(NC(=O)CN4C(=O)CCC4=O)sc3c2s1,2.30192
86120,Please optimize the molecule CCOc1cccc(C(=O)Cc2[nH+]ccn2C)c1 to have a higher LogP value.,CCOc1cccc(C(=O)Cc2[nH+]ccn2C)c1,1.6633
238515,Optimize the molecule C[C@H]1CCCN(C(=O)NCCOCC(F)(F)F)CC1 to have a higher LogP value.,C[C@H]1CCCN(C(=O)NCCOCC(F)(F)F)CC1,2.3969000000000005
123177,Please optimize the molecule CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2 to have a lower LogP value.,CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2,2.1721000000000004
48822,Modify the molecule COc1ccc(C(=O)N2CCC[C@H]2CC(C)=O)cc1O to decrease its LogP value.,COc1ccc(C(=O)N2CCC[C@H]2CC(C)=O)cc1O,1.9845000000000002
175371,Please optimize the molecule COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1 to have a higher LogP value.,COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1,0.29120000000000146
130765,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccnc(Cl)n1 to have a lower LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccnc(Cl)n1,2.9083000000000014
200885,Please modify the molecule CC(=C1C(=O)c2ccccc2C1=O)N1CC[C@H]2CCCN2C1 to decrease its LogP value.,CC(=C1C(=O)c2ccccc2C1=O)N1CC[C@H]2CCCN2C1,2.467200000000001
214276,Please optimize the molecule O=[N+]([O-])c1c(Nc2ccccc2F)ncnc1N1CCCCC1 to have a lower LogP value.,O=[N+]([O-])c1c(Nc2ccccc2F)ncnc1N1CCCCC1,3.2578000000000014
74139,Please modify the molecule COc1cccc(-c2cn[nH]c2C2CCN(Cc3[nH+]ccn3C)CC2)c1 to decrease its LogP value.,COc1cccc(-c2cn[nH]c2C2CCN(Cc3[nH+]ccn3C)CC2)c1,2.6175000000000006
207734,Modify the molecule C[C@@]12C(=O)N(C3CC[NH+](Cc4ccccc4)CC3)CC(=O)N1CCc1c2[nH]c2ccccc12 to have a higher LogP value.,C[C@@]12C(=O)N(C3CC[NH+](Cc4ccccc4)CC3)CC(=O)N1CCc1c2[nH]c2ccccc12,1.8575000000000008
143622,Modify the molecule C[C@H]1COCCN1C(=O)CCCc1cc(F)ccc1F to decrease its LogP value.,C[C@H]1COCCN1C(=O)CCCc1cc(F)ccc1F,2.5348000000000006
239539,Modify the molecule CCC(=O)N1CCN(Cc2cccn2C)CC1 to decrease its LogP value.,CCC(=O)N1CCN(Cc2cccn2C)CC1,1.0793
103533,Optimize the molecule COc1cc(Cl)c(C)cc1N1C(=O)C[C@H](N2CCN(c3ccc(O)cc3)CC2)C1=O to have a higher LogP value.,COc1cc(Cl)c(C)cc1N1C(=O)C[C@H](N2CCN(c3ccc(O)cc3)CC2)C1=O,2.816720000000001
4755,Modify the molecule O=C([O-])c1cc(C2CC2)nc2c(-c3ccc(Cl)cc3)cnn12 to decrease its LogP value.,O=C([O-])c1cc(C2CC2)nc2c(-c3ccc(Cl)cc3)cnn12,2.2905999999999995
135237,Please modify the molecule CC(=O)OCC(=O)C1=c2ccccc2=[NH+][C@H]1c1ccccc1 to increase its LogP value.,CC(=O)OCC(=O)C1=c2ccccc2=[NH+][C@H]1c1ccccc1,-0.5753999999999988
60996,Optimize the molecule N#CCNC(=O)CCS(=O)(=O)Cc1ccccc1 to have a lower LogP value.,N#CCNC(=O)CCS(=O)(=O)Cc1ccccc1,0.6312799999999994
116,Optimize the molecule Cc1nnccc1C(=O)N[C@H](C)c1ccc(Cl)s1 to have a lower LogP value.,Cc1nnccc1C(=O)N[C@H](C)c1ccc(Cl)s1,2.990920000000001
110016,Optimize the molecule O=C(NNc1cccc(F)c1F)Nc1ccc(N2CCCC2)[nH+]c1 to have a higher LogP value.,O=C(NNc1cccc(F)c1F)Nc1ccc(N2CCCC2)[nH+]c1,2.5277000000000003
54095,Please modify the molecule Cc1cc(C)n(CCCOc2ccc(S(C)(=O)=O)cc2)n1 to increase its LogP value.,Cc1cc(C)n(CCCOc2ccc(S(C)(=O)=O)cc2)n1,2.3725400000000008
200778,Optimize the molecule C[C@@H]1Cc2ccccc2N1C(=O)C[C@H](O)c1ccc(Cl)cc1 to have a lower LogP value.,C[C@@H]1Cc2ccccc2N1C(=O)C[C@H](O)c1ccc(Cl)cc1,3.7413000000000034
180338,Modify the molecule CCOC(=O)CN1CCN(c2ccccc2OC)C(=O)[C@H]1C to have a lower LogP value.,CCOC(=O)CN1CCN(c2ccccc2OC)C(=O)[C@H]1C,1.2953999999999999
8980,Please modify the molecule O=C([O-])CC1(NC(=O)C2(c3ccccc3)CC2)CCC1 to increase its LogP value.,O=C([O-])CC1(NC(=O)C2(c3ccccc3)CC2)CCC1,0.8971000000000007
189413,Modify the molecule C[C@H](SCc1cnn(-c2ccccc2)c1)C(=O)Nc1ccc2c(c1)CCC2 to have a higher LogP value.,C[C@H](SCc1cnn(-c2ccccc2)c1)C(=O)Nc1ccc2c(c1)CCC2,4.621400000000004
45972,Modify the molecule C[NH+]1CCN(Cc2ccc(CNC(=O)c3cn4cccnc4n3)cc2)CC1 to increase its LogP value.,C[NH+]1CCN(Cc2ccc(CNC(=O)c3cn4cccnc4n3)cc2)CC1,-0.010399999999997744
172375,Please modify the molecule Cc1nsc(N[C@@H]2CC[NH+](C3CC3)C2)c1C#N to decrease its LogP value.,Cc1nsc(N[C@@H]2CC[NH+](C3CC3)C2)c1C#N,0.5547
136445,Please modify the molecule Cc1ccc(NC(=O)C(=O)NCCc2ccccc2)c(C)c1 to increase its LogP value.,Cc1ccc(NC(=O)C(=O)NCCc2ccccc2)c(C)c1,2.6008400000000007
10165,Please modify the molecule COc1c(Br)cc(Br)cc1/C=C/C(=O)Nc1ccc2c(c1)C(=O)N(C)C2=O to decrease its LogP value.,COc1c(Br)cc(Br)cc1/C=C/C(=O)Nc1ccc2c(c1)C(=O)N(C)C2=O,4.097900000000004
22291,Modify the molecule Cc1noc(C)c1CCC(=O)[C@H](C#N)c1nc2sc3c(c2c(=O)[nH]1)CCCC3 to have a lower LogP value.,Cc1noc(C)c1CCC(=O)[C@H](C#N)c1nc2sc3c(c2c(=O)[nH]1)CCCC3,3.2773200000000013
14711,Modify the molecule O=C(N/N=C\c1cc(Br)c(Br)s1)c1ccncc1 to increase its LogP value.,O=C(N/N=C\c1cc(Br)c(Br)s1)c1ccncc1,3.4320000000000013
95124,Please optimize the molecule Cc1ccc(CNC(=O)NC[C@H](c2ccco2)[NH+](C)C)cn1 to have a higher LogP value.,Cc1ccc(CNC(=O)NC[C@H](c2ccco2)[NH+](C)C)cn1,0.6680200000000001
104840,Optimize the molecule Cc1ccc(O)c(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1 to have a higher LogP value.,Cc1ccc(O)c(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1,0.30722000000000055
132436,Please modify the molecule CCOCc1ccc(CNC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1 to increase its LogP value.,CCOCc1ccc(CNC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1,3.9432000000000036
1123,Optimize the molecule Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1cnc(-c2ccccc2)s1 to have a higher LogP value.,Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1cnc(-c2ccccc2)s1,4.279020000000002
12511,Modify the molecule COc1ccc([C@H](C)NC(=O)Cc2ccc(C)cc2)cc1 to decrease its LogP value.,COc1ccc([C@H](C)NC(=O)Cc2ccc(C)cc2)cc1,3.4235200000000026
193152,Please modify the molecule Cc1nn(C)c(C)c1NC(=O)[C@H](C)[NH+]1CCCSCC1 to decrease its LogP value.,Cc1nn(C)c(C)c1NC(=O)[C@H](C)[NH+]1CCCSCC1,0.3857400000000011
248807,Please modify the molecule O=c1c2c(-c3ccc(F)cc3)csc2[nH]c(=S)n1Cc1ccccc1 to decrease its LogP value.,O=c1c2c(-c3ccc(F)cc3)csc2[nH]c(=S)n1Cc1ccccc1,4.974990000000003
44982,Modify the molecule Cc1ccc(OCC2(O)CCCC2)c(C[NH2+]C2CC2)n1 to decrease its LogP value.,Cc1ccc(OCC2(O)CCCC2)c(C[NH2+]C2CC2)n1,1.2997199999999998
137474,Please optimize the molecule CC[NH2+][C@H](C)c1ccc(Oc2cccc(Cl)c2)c(F)c1 to have a higher LogP value.,CC[NH2+][C@H](C)c1ccc(Oc2cccc(Cl)c2)c(F)c1,3.915700000000003
148242,Please optimize the molecule CN(Cc1cnn(-c2ccccc2)c1)C(=O)c1ccccc1O to have a lower LogP value.,CN(Cc1cnn(-c2ccccc2)c1)C(=O)c1ccccc1O,2.8501000000000016
71805,Modify the molecule CCN(CC(=O)NC)C(=O)c1ccncc1/C=C/C(=O)[O-] to have a higher LogP value.,CCN(CC(=O)NC)C(=O)c1ccncc1/C=C/C(=O)[O-],-0.9471999999999996
27968,Please modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCn1nc(C)c(Cl)c1C to increase its LogP value.,C[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCn1nc(C)c(Cl)c1C,0.02544000000000035
67360,Please modify the molecule Cc1ncsc1[C@@H]1N[C@H](C(=O)[O-])C(C)(C)S1 to decrease its LogP value.,Cc1ncsc1[C@@H]1N[C@H](C(=O)[O-])C(C)(C)S1,0.6836199999999999
116332,Modify the molecule CC(C)(CNc1cc(OC(F)F)c(F)cc1N)S(C)(=O)=O to have a higher LogP value.,CC(C)(CNc1cc(OC(F)F)c(F)cc1N)S(C)(=O)=O,2.2443999999999997
106537,Please modify the molecule Cc1ccc(N2CCCC2=O)c(C(=O)Nc2cccc(-n3cnnn3)c2)c1 to decrease its LogP value.,Cc1ccc(N2CCCC2=O)c(C(=O)Nc2cccc(-n3cnnn3)c2)c1,2.3498200000000002
165339,Please optimize the molecule CC1=C(C(=O)Nc2ccccc2F)[C@H](c2ccccc2F)NC(=O)N1 to have a lower LogP value.,CC1=C(C(=O)Nc2ccccc2F)[C@H](c2ccccc2F)NC(=O)N1,3.2314000000000007
87133,Modify the molecule O=C(Nc1ncccc1Cl)c1ccc(Cl)cc1 to decrease its LogP value.,O=C(Nc1ncccc1Cl)c1ccc(Cl)cc1,3.6407000000000016
132253,Please optimize the molecule C[C@H](NC(=O)NCC(C)(C)c1ccc2c(c1)OCO2)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)NCC(C)(C)c1ccc2c(c1)OCO2)C1CC1,2.7906000000000013
235271,Please modify the molecule Cc1cc(C)c2nc(NC(=O)[C@@H]3CCCO3)sc2c1 to decrease its LogP value.,Cc1cc(C)c2nc(NC(=O)[C@@H]3CCCO3)sc2c1,3.0306400000000018
190289,Modify the molecule C/C(=N\NC(=O)[C@H]1C=C(c2ccccc2)N=N1)c1ccc(Cl)c(Cl)c1 to decrease its LogP value.,C/C(=N\NC(=O)[C@H]1C=C(c2ccccc2)N=N1)c1ccc(Cl)c(Cl)c1,4.709100000000003
165694,Please optimize the molecule O=C(NC[C@H]1COC2(CCCCC2)O1)c1ccc(Cl)cc1 to have a lower LogP value.,O=C(NC[C@H]1COC2(CCCCC2)O1)c1ccc(Cl)cc1,3.145600000000001
100714,Please optimize the molecule Cc1cc(NC(=O)N(C)C[C@@H](O)C2CC2)ccc1Br to have a higher LogP value.,Cc1cc(NC(=O)N(C)C[C@@H](O)C2CC2)ccc1Br,2.9921200000000017
46760,Modify the molecule CCC[NH2+][C@H](c1cccc(OC)c1)c1cscc1Br to decrease its LogP value.,CCC[NH2+][C@H](c1cccc(OC)c1)c1cscc1Br,3.5820000000000016
61631,Please modify the molecule CC[NH+](CC)[C@@H](CN/C=C1/C(=O)NC(=O)c2ccccc21)c1ccsc1 to increase its LogP value.,CC[NH+](CC)[C@@H](CN/C=C1/C(=O)NC(=O)c2ccccc21)c1ccsc1,1.6146000000000003
144151,Please modify the molecule CC1=C(C(=O)[O-])[C@H](c2ccc(Cl)cc2)n2ncnc2N1 to decrease its LogP value.,CC1=C(C(=O)[O-])[C@H](c2ccc(Cl)cc2)n2ncnc2N1,0.9702999999999999
218147,Modify the molecule C[C@@H]1CCC[C@](CCSc2ccccc2)(C(=O)[O-])C1 to have a lower LogP value.,C[C@@H]1CCC[C@](CCSc2ccccc2)(C(=O)[O-])C1,3.1152000000000015
164447,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)N[C@@H]2CCCc3c2cnn3C)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)N[C@@H]2CCCc3c2cnn3C)C1,2.4850000000000003
107682,Please modify the molecule CCCCOc1ccc(C(=O)NCc2ccsc2)cc1 to decrease its LogP value.,CCCCOc1ccc(C(=O)NCc2ccsc2)cc1,3.857000000000003
169777,Please modify the molecule Fc1ccc(Br)c(CNC[C@H]2COc3ccccc32)c1 to increase its LogP value.,Fc1ccc(Br)c(CNC[C@H]2COc3ccccc32)c1,3.8540000000000028
88806,Optimize the molecule C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1 to have a lower LogP value.,C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1,2.3387000000000002
170893,Modify the molecule Cc1ccc(CNC(=O)[C@@H]2CC(=O)N(CCN3CCOCC3)C2)cc1 to have a higher LogP value.,Cc1ccc(CNC(=O)[C@@H]2CC(=O)N(CCN3CCOCC3)C2)cc1,0.7919200000000008
214850,Modify the molecule C[C@H]1Cc2cc(S(N)(=O)=O)ccc2N1Cc1nnsc1Cl to have a higher LogP value.,C[C@H]1Cc2cc(S(N)(=O)=O)ccc2N1Cc1nnsc1Cl,1.7900999999999998
67173,Optimize the molecule O=C(NCCc1c[nH]c2ccccc12)c1cn(CCC2CCCCC2)nn1 to have a higher LogP value.,O=C(NCCc1c[nH]c2ccccc12)c1cn(CCC2CCCCC2)nn1,3.702300000000003
120772,Please modify the molecule CCn1c(-c2ccccc2)nn(C[NH+]2CCC[C@@H](C)C2)c1=S to decrease its LogP value.,CCn1c(-c2ccccc2)nn(C[NH+]2CCC[C@@H](C)C2)c1=S,2.373290000000001
140361,Optimize the molecule O=C(Nc1ccc(F)cc1OCC(F)F)[C@@H]1CC(=O)N(C2CCCC2)C1 to have a higher LogP value.,O=C(Nc1ccc(F)cc1OCC(F)F)[C@@H]1CC(=O)N(C2CCCC2)C1,3.199200000000002
36650,Modify the molecule C[C@@H]1CCN(C(=O)Nc2ccccc2N2CCCCCC2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)Nc2ccccc2N2CCCCCC2)C[C@@H]1O,3.3016000000000028
193321,Please modify the molecule COc1ccccc1C(=O)CCc1cc(C)cc(C)c1 to decrease its LogP value.,COc1ccccc1C(=O)CCc1cc(C)cc(C)c1,4.127540000000003
29014,Modify the molecule C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1 to decrease its LogP value.,C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1,1.9899
214806,Modify the molecule O[C@@H]1CCCC[C@H]1[NH2+]Cc1ccc(F)cc1 to decrease its LogP value.,O[C@@H]1CCCC[C@H]1[NH2+]Cc1ccc(F)cc1,1.1925999999999994
116230,Modify the molecule COc1cccc(C(=O)NCc2c(C)nn(-c3ccccc3)c2C)c1 to increase its LogP value.,COc1cccc(C(=O)NCc2c(C)nn(-c3ccccc3)c2C)c1,3.427740000000002
47924,Please optimize the molecule O[C@H](COCc1ccccc1)CSc1ccc2ccccc2n1 to have a higher LogP value.,O[C@H](COCc1ccccc1)CSc1ccc2ccccc2n1,3.904600000000003
199964,Modify the molecule COC(=O)C[C@@H]1SC2=C(C(=O)Nc3cccc(C)c3)[C@@H](c3cccc(F)c3)C(C#N)=C(N)N2C1=O to increase its LogP value.,COC(=O)C[C@@H]1SC2=C(C(=O)Nc3cccc(C)c3)[C@@H](c3cccc(F)c3)C(C#N)=C(N)N2C1=O,3.2826000000000004
90416,Modify the molecule CC1=NC(=O)[C@H](CC(=O)[O-])CS1 to increase its LogP value.,CC1=NC(=O)[C@H](CC(=O)[O-])CS1,-0.5655999999999999
40051,Optimize the molecule Cn1nnnc1SCC(=O)N1CCO[C@H](c2cccs2)C1 to have a higher LogP value.,Cn1nnnc1SCC(=O)N1CCO[C@H](c2cccs2)C1,0.9637999999999997
95668,Please optimize the molecule CC(C)(C)NC(=O)Cn1cc(C(N)=O)c(-c2ccccc2)n1 to have a lower LogP value.,CC(C)(C)NC(=O)Cn1cc(C(N)=O)c(-c2ccccc2)n1,1.5636999999999996
25070,Modify the molecule CCCN1C(=O)N=C(N)[C@@H]1c1ccc(F)cc1F to decrease its LogP value.,CCCN1C(=O)N=C(N)[C@@H]1c1ccc(F)cc1F,2.2087000000000003
16127,Please optimize the molecule O=[N+]([O-])c1ccc(CN2CC[NH+](Cc3cccnc3)CC2)cc1 to have a lower LogP value.,O=[N+]([O-])c1ccc(CN2CC[NH+](Cc3cccnc3)CC2)cc1,0.8904999999999994
197742,Modify the molecule C[C@H]1CNc2cc(Br)cnc2N1 to increase its LogP value.,C[C@H]1CNc2cc(Br)cnc2N1,2.07
90299,Please optimize the molecule O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1 to have a higher LogP value.,O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1,0.7457999999999998
101042,Modify the molecule O=C(NC[C@]1(c2ccccc2)CCCOCC1)c1ccc(F)cc1Cl to decrease its LogP value.,O=C(NC[C@]1(c2ccccc2)CCCOCC1)c1ccc(F)cc1Cl,4.347400000000004
138176,Please modify the molecule CSc1ccccc1C[NH+]1CCC(CNC(=O)NCc2ccccc2)CC1 to decrease its LogP value.,CSc1ccccc1C[NH+]1CCC(CNC(=O)NCc2ccccc2)CC1,2.7028000000000008
93568,Please modify the molecule CCOC(=O)C1(C)CC[NH+]([C@H](C)C(=O)Nc2cc(Cl)ccc2C)CC1 to decrease its LogP value.,CCOC(=O)C1(C)CC[NH+]([C@H](C)C(=O)Nc2cc(Cl)ccc2C)CC1,2.2235199999999997
21229,Please modify the molecule Cc1c(Cl)cccc1-n1nc(C)c2c(C)cc(OCC(=O)Nc3ccc4c(c3)OCCO4)nc21 to decrease its LogP value.,Cc1c(Cl)cccc1-n1nc(C)c2c(C)cc(OCC(=O)Nc3ccc4c(c3)OCCO4)nc21,4.787860000000004
68761,Please modify the molecule COc1ccc(NS(=O)(=O)c2ccc(F)c(C)c2)cc1 to increase its LogP value.,COc1ccc(NS(=O)(=O)c2ccc(F)c(C)c2)cc1,2.9435200000000012
176736,Optimize the molecule O=C(/C=C/c1ccncc1)NCCc1nc2ccc(F)cc2[nH]1 to have a higher LogP value.,O=C(/C=C/c1ccncc1)NCCc1nc2ccc(F)cc2[nH]1,2.4691
16439,Optimize the molecule COc1cc(C(=O)NCc2cnn(C)c2)cc(OC)c1OC(F)F to have a lower LogP value.,COc1cc(C(=O)NCc2cnn(C)c2)cc(OC)c1OC(F)F,1.9686999999999997
118238,Modify the molecule COc1ccc(S(N)(=O)=O)cc1C(=O)NC[C@@H](C)c1ccsc1 to increase its LogP value.,COc1ccc(S(N)(=O)=O)cc1C(=O)NC[C@@H](C)c1ccsc1,1.9376000000000002
89254,Optimize the molecule CS(=O)(=O)N1CCC[C@@H](Nc2cc(-c3ccccc3)nc3ncnn23)C1 to have a lower LogP value.,CS(=O)(=O)N1CCC[C@@H](Nc2cc(-c3ccccc3)nc3ncnn23)C1,1.6271999999999998
210467,Modify the molecule O=C(Nc1nnc(S(=O)(=O)NCc2ccccc2)s1)C1CCCCC1 to have a lower LogP value.,O=C(Nc1nnc(S(=O)(=O)NCc2ccccc2)s1)C1CCCCC1,2.535400000000001
137318,Optimize the molecule CCOc1cc(C#N)ccc1OCC(=O)Nc1c(Cl)cccc1C(F)(F)F to have a higher LogP value.,CCOc1cc(C#N)ccc1OCC(=O)Nc1c(Cl)cccc1C(F)(F)F,4.646680000000002
65543,Please modify the molecule CC[C@@H](CO)[NH+]1CCN([C@H](C)C(=O)NC(=O)Nc2ccccc2F)CC1 to decrease its LogP value.,CC[C@@H](CO)[NH+]1CCN([C@H](C)C(=O)NC(=O)Nc2ccccc2F)CC1,-0.166299999999997
95786,Modify the molecule CC(C)CN1CCO[C@H](CNC(=O)C(=O)Nc2ccccc2C(C)C)C1 to decrease its LogP value.,CC(C)CN1CCO[C@H](CNC(=O)C(=O)Nc2ccccc2C(C)C)C1,2.2215
161749,Optimize the molecule CCS(=O)(=O)c1ccc(C(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1 to have a higher LogP value.,CCS(=O)(=O)c1ccc(C(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1,5.009200000000004
94833,Please modify the molecule O=C(NCCN1CC[NH+](Cc2ccccc2)CC1)N1CCC[C@H](CO)C1 to increase its LogP value.,O=C(NCCN1CC[NH+](Cc2ccccc2)CC1)N1CCC[C@H](CO)C1,-0.1989999999999969
137945,Modify the molecule Cc1cc(C)c2[nH]c(C(=O)N3CC[C@@H](c4ccccc4F)C3)c(C)c2c1 to decrease its LogP value.,Cc1cc(C)c2[nH]c(C(=O)N3CC[C@@H](c4ccccc4F)C3)c(C)c2c1,4.861960000000004
41875,Please optimize the molecule CC1CCN(c2ccc(CNC(=O)NCCn3cccc3)c[nH+]2)CC1 to have a lower LogP value.,CC1CCN(c2ccc(CNC(=O)NCCn3cccc3)c[nH+]2)CC1,2.0379
153205,Please modify the molecule CC(=O)N1CCC[C@H]1c1cnccn1 to increase its LogP value.,CC(=O)N1CCC[C@H]1c1cnccn1,1.16
245358,Please optimize the molecule CC(C)CCn1nc(C(=O)[O-])c2c1CCN(C(=O)[C@@H]1CCc3nn(C)c(=O)n3C1)C2 to have a lower LogP value.,CC(C)CCn1nc(C(=O)[O-])c2c1CCN(C(=O)[C@@H]1CCc3nn(C)c(=O)n3C1)C2,-0.6647999999999976
207288,Modify the molecule O=C(N[C@H]1CCN(c2ccccc2)C1)N1CCc2cc(F)ccc2C1 to decrease its LogP value.,O=C(N[C@H]1CCN(c2ccccc2)C1)N1CCc2cc(F)ccc2C1,3.1723000000000017
152005,Please modify the molecule CNC(=O)NCC(=O)N[C@@H]1c2cccc(F)c2CC[C@@H]1C to decrease its LogP value.,CNC(=O)NCC(=O)N[C@@H]1c2cccc(F)c2CC[C@@H]1C,1.4943000000000004
11697,Optimize the molecule COCCNC(=O)c1cccc(C(=O)OC)c1 to have a lower LogP value.,COCCNC(=O)c1cccc(C(=O)OC)c1,0.8493999999999997
46000,Modify the molecule C[NH+](C)[C@@H]1CCCN(Cc2ccc([N+](=O)[O-])o2)C1 to increase its LogP value.,C[NH+](C)[C@@H]1CCCN(Cc2ccc([N+](=O)[O-])o2)C1,0.2967000000000011
106629,Optimize the molecule OC[C@H](Cc1ccc(Cl)cc1)N1CN[C@H](c2ccccc2)[C@H]1c1[nH]cc[nH+]1 to have a higher LogP value.,OC[C@H](Cc1ccc(Cl)cc1)N1CN[C@H](c2ccccc2)[C@H]1c1[nH]cc[nH+]1,2.7309
249119,Optimize the molecule CC(C)(C)C(=O)Nc1nc2c(s1)C[C@H]1[C@](C)(CC[C@@H](O)[C@@]1(C)CO)[C@@H]2CC(=O)[O-] to have a higher LogP value.,CC(C)(C)C(=O)Nc1nc2c(s1)C[C@H]1[C@](C)(CC[C@@H](O)[C@@]1(C)CO)[C@@H]2CC(=O)[O-],1.6831999999999998
61368,Please modify the molecule Cc1ccc2c(c1)c(-c1csc(N)n1)c(C)n2C to decrease its LogP value.,Cc1ccc2c(c1)c(-c1csc(N)n1)c(C)n2C,3.500840000000001
211278,Modify the molecule CN(C)/C=N\C(=O)NN(C)c1ncc(C(F)(F)F)cc1Cl to increase its LogP value.,CN(C)/C=N\C(=O)NN(C)c1ncc(C(F)(F)F)cc1Cl,2.4045000000000005
7839,Please optimize the molecule Clc1cccc(-c2nnc(Cn3nccc3-c3ccncc3)o2)c1 to have a lower LogP value.,Clc1cccc(-c2nnc(Cn3nccc3-c3ccncc3)o2)c1,3.6968000000000023
194623,Optimize the molecule Cc1cc(C)cc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)o2)c1 to have a lower LogP value.,Cc1cc(C)cc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)o2)c1,4.433440000000004
11189,Modify the molecule Cc1ccc(/C=C/C(=O)NCC2CCC(C(=O)[O-])CC2)s1 to increase its LogP value.,Cc1ccc(/C=C/C(=O)NCC2CCC(C(=O)[O-])CC2)s1,1.7422199999999997
155789,Please optimize the molecule CCC(CC)NC(=O)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1 to have a lower LogP value.,CCC(CC)NC(=O)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,3.5107000000000026
69971,Modify the molecule C(=N/N1CCN(C2c3ccccc3-c3ccccc32)CC1)\c1ccc2c(c1)OCCO2 to increase its LogP value.,C(=N/N1CCN(C2c3ccccc3-c3ccccc32)CC1)\c1ccc2c(c1)OCCO2,4.179300000000003
82890,Modify the molecule Cc1ccc(-c2cc(C(=O)NNC(=O)c3ccco3)c3ccccc3n2)cc1 to have a lower LogP value.,Cc1ccc(-c2cc(C(=O)NNC(=O)c3ccco3)c3ccccc3n2)cc1,3.878020000000001
219536,Optimize the molecule Cc1c(CNC(=O)Cn2nc([O-])ccc2=O)cnn1C to have a higher LogP value.,Cc1c(CNC(=O)Cn2nc([O-])ccc2=O)cnn1C,-1.3247799999999992
209805,Modify the molecule CC[NH+](CCn1cnc2ccsc2c1=O)[C@@H](C)c1ccc(F)cc1 to have a lower LogP value.,CC[NH+](CCn1cnc2ccsc2c1=O)[C@@H](C)c1ccc(F)cc1,2.2631000000000006
123454,Modify the molecule [NH3+]CCc1cc(-c2cc(F)cc(F)c2)[nH]n1 to increase its LogP value.,[NH3+]CCc1cc(-c2cc(F)cc(F)c2)[nH]n1,1.1393
56345,Please modify the molecule Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1 to increase its LogP value.,Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1,3.058340000000001
155596,Optimize the molecule O=C1NC(=O)C(=Cc2ccc(OCc3c(F)cccc3Cl)cc2)C(=O)N1 to have a higher LogP value.,O=C1NC(=O)C(=Cc2ccc(OCc3c(F)cccc3Cl)cc2)C(=O)N1,2.807500000000001
206505,Optimize the molecule C[NH2+]C[C@@H](C)C(=O)N[C@@H](C)Cn1cccn1 to have a lower LogP value.,C[NH2+]C[C@@H](C)C(=O)N[C@@H](C)Cn1cccn1,-0.7828999999999982
99365,Please modify the molecule Cc1ccc2[nH]c(C[NH+]3C[C@H]4CC[C@@H]3CN(C(=O)c3cnccn3)C4)c(C)c2c1 to decrease its LogP value.,Cc1ccc2[nH]c(C[NH+]3C[C@H]4CC[C@@H]3CN(C(=O)c3cnccn3)C4)c(C)c2c1,1.8942400000000001
26154,Modify the molecule C[C@H]1C[C@H](Nc2ccc(SC(F)F)cc2)CS1 to have a lower LogP value.,C[C@H]1C[C@H](Nc2ccc(SC(F)F)cc2)CS1,4.307200000000003
208735,Please modify the molecule C[C@H]1CCc2c(sc(NC(=O)[C@@H]3CCS(=O)(=O)C3)c2C(=O)c2ccccc2)C1 to decrease its LogP value.,C[C@H]1CCc2c(sc(NC(=O)[C@@H]3CCS(=O)(=O)C3)c2C(=O)c2ccccc2)C1,3.4771000000000027
10952,Please optimize the molecule N#Cc1cccc(C(=O)N[C@H]2[C@H](O)[C@H](O)C[C@@H]2c2ccc(C(F)(F)F)cc2)c1 to have a lower LogP value.,N#Cc1cccc(C(=O)N[C@H]2[C@H](O)[C@H](O)C[C@@H]2c2ccc(C(F)(F)F)cc2)c1,2.5847800000000003
244514,Modify the molecule C[C@@H](CCc1ccc2c(c1)OCO2)[NH2+]C[C@@H]1CCCN(c2ncccn2)C1 to have a higher LogP value.,C[C@@H](CCc1ccc2c(c1)OCO2)[NH2+]C[C@@H]1CCCN(c2ncccn2)C1,2.0063999999999993
232007,Please modify the molecule Cc1nc(C)c(CNC(=O)c2cc(C3CC3)nc3ccc(F)cc23)s1 to increase its LogP value.,Cc1nc(C)c(CNC(=O)c2cc(C3CC3)nc3ccc(F)cc23)s1,4.254640000000004
179014,Please optimize the molecule O=C(NCc1ccsc1)NCC1CCC(C(=O)[O-])CC1 to have a lower LogP value.,O=C(NCc1ccsc1)NCC1CCC(C(=O)[O-])CC1,1.1036
120231,Please optimize the molecule CCSc1ccc([C@@H](C)NCc2sc(C)nc2C)cc1 to have a higher LogP value.,CCSc1ccc([C@@H](C)NCc2sc(C)nc2C)cc1,4.722740000000004
133664,Please optimize the molecule O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1 to have a lower LogP value.,O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1,1.1178999999999997
156549,Please optimize the molecule Cc1ccccc1NC(=O)[C@@H](C)Oc1ccc2ccc(=O)oc2c1 to have a lower LogP value.,Cc1ccccc1NC(=O)[C@@H](C)Oc1ccc2ccc(=O)oc2c1,3.5074200000000015
244888,Modify the molecule O=C(NCCCCC1CCCC1)c1nccn2ccnc12 to have a higher LogP value.,O=C(NCCCCC1CCCC1)c1nccn2ccnc12,2.819600000000001
207735,Optimize the molecule CC[C@H]1CC[C@H]([NH+]2CCC(C(=O)Nc3ccccc3Br)CC2)C1 to have a higher LogP value.,CC[C@H]1CC[C@H]([NH+]2CCC(C(=O)Nc3ccccc3Br)CC2)C1,3.2612000000000014
248727,Please modify the molecule CC1(C)Cc2cccc(OCc3nccc(N)n3)c2O1 to increase its LogP value.,CC1(C)Cc2cccc(OCc3nccc(N)n3)c2O1,2.3513
177847,Please modify the molecule CCOC(=O)C(=Cc1cc2ccc(C)cc2nc1Cl)C(=O)OCC to increase its LogP value.,CCOC(=O)C(=Cc1cc2ccc(C)cc2nc1Cl)C(=O)OCC,3.7062200000000036
25724,Optimize the molecule C[C@H](CO)[C@@H](C)NC(=O)Nc1cc(-c2ccccc2)on1 to have a lower LogP value.,C[C@H](CO)[C@@H](C)NC(=O)Nc1cc(-c2ccccc2)on1,2.4800000000000004
67400,Please optimize the molecule COC(=O)Cc1nn(-c2ccc(C)cc2)c2c1nnc1nc(-c3ccccc3Cl)nn12 to have a lower LogP value.,COC(=O)Cc1nn(-c2ccc(C)cc2)c2c1nnc1nc(-c3ccccc3Cl)nn12,3.2025200000000016
196617,Please modify the molecule COC(=O)[C@@H]1C[C@@H](O)CN1CC(=O)N1CCCCCC1 to increase its LogP value.,COC(=O)[C@@H]1C[C@@H](O)CN1CC(=O)N1CCCCCC1,-0.0027999999999999137
147543,Modify the molecule CC[NH+](CC)CCNC(=O)c1ccc(C)cc1F to decrease its LogP value.,CC[NH+](CC)CCNC(=O)c1ccc(C)cc1F,0.7886199999999999
161624,Optimize the molecule c1ccc2c(c1)ccc1c3ccccc3oc21 to have a lower LogP value.,c1ccc2c(c1)ccc1c3ccccc3oc21,4.739200000000002
61119,Modify the molecule Cc1ccccc1-n1c(C)nnc1SCC(=O)NC1CC1 to decrease its LogP value.,Cc1ccccc1-n1c(C)nnc1SCC(=O)NC1CC1,2.2548399999999997
119393,Modify the molecule COc1cccc(CCCNC(=O)c2c[nH]c3ccc([N+](=O)[O-])cc23)c1 to have a higher LogP value.,COc1cccc(CCCNC(=O)c2c[nH]c3ccc([N+](=O)[O-])cc23)c1,3.447300000000001
78474,Modify the molecule Cc1ccc(N2CC[C@H](C(=O)N[C@H](c3ncc(C)s3)C3CC3)C2=O)cc1 to decrease its LogP value.,Cc1ccc(N2CC[C@H](C(=O)N[C@H](c3ncc(C)s3)C3CC3)C2=O)cc1,3.380340000000002
4546,Please modify the molecule O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)c2cccs2)C1 to decrease its LogP value.,O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)c2cccs2)C1,3.2390000000000017
74627,Modify the molecule Cc1ccc(N2CC[C@@H](NC(=O)CC(C)(C)C)C2=O)cc1C to increase its LogP value.,Cc1ccc(N2CC[C@@H](NC(=O)CC(C)(C)C)C2=O)cc1C,2.961140000000001
111459,Modify the molecule CCCNC(=O)[C@@H](C)[NH+]1CCCN(S(=O)(=O)c2ccccc2)CC1 to decrease its LogP value.,CCCNC(=O)[C@@H](C)[NH+]1CCCN(S(=O)(=O)c2ccccc2)CC1,-0.11939999999999684
224014,Modify the molecule COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1 to have a higher LogP value.,COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1,-1.5036999999999978
45906,Please modify the molecule COCC[C@H](NC(=O)N1CCN2C(=O)NC[C@H]2C1)C(=O)[O-] to decrease its LogP value.,COCC[C@H](NC(=O)N1CCN2C(=O)NC[C@H]2C1)C(=O)[O-],-2.439599999999996
202975,Modify the molecule COCc1nc2cc(NC(=O)c3csc(C)n3)ccc2o1 to have a higher LogP value.,COCc1nc2cc(NC(=O)c3csc(C)n3)ccc2o1,2.9914200000000015
120474,Modify the molecule O=C1N[C@]2(CCOc3ccccc32)C(=O)N1CC(=O)N1CCCSc2ccccc21 to have a higher LogP value.,O=C1N[C@]2(CCOc3ccccc32)C(=O)N1CC(=O)N1CCCSc2ccccc21,2.7452000000000014
204951,Please optimize the molecule CC(=O)[C@H](C)n1c(CNC(=O)/C=C\c2ccccc2)nc2ccccc21 to have a lower LogP value.,CC(=O)[C@H](C)n1c(CNC(=O)/C=C\c2ccccc2)nc2ccccc21,3.515900000000002
120341,Modify the molecule COCc1nc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cs1 to have a higher LogP value.,COCc1nc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cs1,0.45920000000000116
4885,Modify the molecule CCOc1ccccc1/C=N/NC(=O)[C@H]1C=C(c2cccc([N+](=O)[O-])c2)N=N1 to decrease its LogP value.,CCOc1ccccc1/C=N/NC(=O)[C@H]1C=C(c2cccc([N+](=O)[O-])c2)N=N1,3.3191000000000015
108954,Modify the molecule C[C@H](CC(=O)[O-])N1C(=O)CCCC1=O to increase its LogP value.,C[C@H](CC(=O)[O-])N1C(=O)CCCC1=O,-0.946
234904,Modify the molecule CCN(C(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12)[C@H](C)c1cccc(OC)c1 to have a higher LogP value.,CCN(C(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12)[C@H](C)c1cccc(OC)c1,3.0587000000000018
221702,Modify the molecule CN(CC[C@H]1CCCC[NH+]1C)C(=O)NCC(C1CC1)C1CC1 to have a higher LogP value.,CN(CC[C@H]1CCCC[NH+]1C)C(=O)NCC(C1CC1)C1CC1,1.5213000000000005
135290,Please modify the molecule Cc1nc(-c2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)cc2)cs1 to increase its LogP value.,Cc1nc(-c2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)cc2)cs1,4.932420000000002
134560,Please optimize the molecule COc1ccc2c(c1OC)C(=O)N1[C@@H](C(=O)NCc3ccco3)CS[C@@H]21 to have a higher LogP value.,COc1ccc2c(c1OC)C(=O)N1[C@@H](C(=O)NCc3ccco3)CS[C@@H]21,2.183
3310,Modify the molecule CC[C@H]1CCCN(C(=O)c2cc(C)n(-c3nccs3)c2C)C1 to have a lower LogP value.,CC[C@H]1CCCN(C(=O)c2cc(C)n(-c3nccs3)c2C)C1,3.812840000000003
23034,Please modify the molecule Cc1cc(F)ccc1NC(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1 to decrease its LogP value.,Cc1cc(F)ccc1NC(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1,2.5685200000000004
237772,Please optimize the molecule COc1cccc(C(=O)N2CCC3(CC2)Nc2ccc(Cl)cc2-n2cccc23)c1 to have a higher LogP value.,COc1cccc(C(=O)N2CCC3(CC2)Nc2ccc(Cl)cc2-n2cccc23)c1,4.6963000000000035
134672,Please modify the molecule O=C(NC[C@H]1CC[NH+](Cc2c[nH]cn2)C1)c1cccc2c1NCCC2 to decrease its LogP value.,O=C(NC[C@H]1CC[NH+](Cc2c[nH]cn2)C1)c1cccc2c1NCCC2,0.6026000000000016
248695,Modify the molecule CNC(=O)c1ccc(OC)c(NC(=O)c2ccc3[nH]c(C)c(C)c3c2)c1 to have a lower LogP value.,CNC(=O)c1ccc(OC)c(NC(=O)c2ccc3[nH]c(C)c(C)c3c2)c1,3.405240000000002
63788,Modify the molecule Cc1cc(NC(=O)CCN(C)[C@H](c2ccccc2)c2ccc(F)cc2)no1 to increase its LogP value.,Cc1cc(NC(=O)CCN(C)[C@H](c2ccccc2)c2ccc(F)cc2)no1,4.172120000000003
107664,Optimize the molecule CCOC(=O)c1ccc(S(=O)(=O)N2CCN(C(=O)OCC)CC2)cc1 to have a lower LogP value.,CCOC(=O)c1ccc(S(=O)(=O)N2CCN(C(=O)OCC)CC2)cc1,1.3260999999999998
83244,Modify the molecule Cn1ccnc1COC(=O)c1ccc(S(=O)(=O)N2CCCc3ccccc32)cc1 to have a lower LogP value.,Cn1ccnc1COC(=O)c1ccc(S(=O)(=O)N2CCCc3ccccc32)cc1,2.9186000000000014
93991,Optimize the molecule Fc1ccccc1[C@@H]1C[NH2+]CC[C@@H]1c1cccc(Br)c1 to have a higher LogP value.,Fc1ccccc1[C@@H]1C[NH2+]CC[C@@H]1c1cccc(Br)c1,3.4227000000000016
181496,Please optimize the molecule CC(C)Oc1ccc(NC(=O)N[C@H](C)[C@H]2CCCO2)cc1Cl to have a higher LogP value.,CC(C)Oc1ccc(NC(=O)N[C@H](C)[C@H]2CCCO2)cc1Cl,3.816200000000002
212402,Modify the molecule COc1cccc(CNC(=O)Nc2ccc3sc(NC(=O)c4ccccc4)nc3c2)c1 to decrease its LogP value.,COc1cccc(CNC(=O)Nc2ccc3sc(NC(=O)c4ccccc4)nc3c2)c1,4.8789000000000025
108575,Please optimize the molecule CC1(C)C(=O)NC(=O)N1CC(=O)N1CCC[C@H]1c1ccc(F)cc1 to have a lower LogP value.,CC1(C)C(=O)NC(=O)N1CC(=O)N1CCC[C@H]1c1ccc(F)cc1,1.8195999999999994
112094,Optimize the molecule O=C(Nc1cccnc1)c1ccc2c(n1)NCCS2 to have a higher LogP value.,O=C(Nc1cccnc1)c1ccc2c(n1)NCCS2,2.2465
176488,Modify the molecule COc1ccc([C@H](C)N[C@H](C)C(=O)N2CCOCC2)c(F)c1 to have a higher LogP value.,COc1ccc([C@H](C)N[C@H](C)C(=O)N2CCOCC2)c(F)c1,1.7322
14337,Modify the molecule C/C=C/CN(c1ncnc2oc(C)nc12)[C@H](C)CC to have a higher LogP value.,C/C=C/CN(c1ncnc2oc(C)nc12)[C@H](C)CC,3.1072200000000016
173853,Modify the molecule COC(=O)C1(NC(=O)c2cnccn2)CCCC1 to decrease its LogP value.,COC(=O)C1(NC(=O)c2cnccn2)CCCC1,0.6921999999999993
189254,Modify the molecule CCS[C@H]1CC[C@H](N(C)C(=O)c2cc(S(=O)(=O)NC)oc2C)C1 to decrease its LogP value.,CCS[C@H]1CC[C@H](N(C)C(=O)c2cc(S(=O)(=O)NC)oc2C)C1,2.2423200000000003
169676,Please modify the molecule Cn1ccnc1SCC(=O)NC(=O)NCc1ccccc1 to increase its LogP value.,Cn1ccnc1SCC(=O)NC(=O)NCc1ccccc1,1.5381999999999996
155880,Please modify the molecule C[C@H](C#N)Oc1ccc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1 to decrease its LogP value.,C[C@H](C#N)Oc1ccc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1,1.1471799999999996
194108,Please modify the molecule CC(C)NS(=O)(=O)c1ccc([C@@H]2CNC(=O)C2)cc1 to increase its LogP value.,CC(C)NS(=O)(=O)c1ccc([C@@H]2CNC(=O)C2)cc1,0.9768
84446,Modify the molecule N#Cc1ccc(CS(=O)(=O)/N=C(\[O-])c2ccc(Br)s2)cc1 to have a lower LogP value.,N#Cc1ccc(CS(=O)(=O)/N=C(\[O-])c2ccc(Br)s2)cc1,2.01918
220268,Optimize the molecule Cc1cc(CNc2ncnc3c2CCCC3)no1 to have a lower LogP value.,Cc1cc(CNc2ncnc3c2CCCC3)no1,2.2639200000000006
215855,Please optimize the molecule O=C(c1ccc(Cl)cn1)[n+]1ccccc1Nc1ccccc1 to have a higher LogP value.,O=C(c1ccc(Cl)cn1)[n+]1ccccc1Nc1ccccc1,3.454600000000001
150688,Modify the molecule CCc1c(C(=O)COc2ccccc2N2CCC[C@@H](C)C2)[nH]c(C)c1C(C)=O to decrease its LogP value.,CCc1c(C(=O)COc2ccccc2N2CCC[C@@H](C)C2)[nH]c(C)c1C(C)=O,4.586120000000004
62632,Please modify the molecule CC(C)([NH3+])CS[C@H]1CCOC2(CCSCC2)C1 to decrease its LogP value.,CC(C)([NH3+])CS[C@H]1CCOC2(CCSCC2)C1,2.1849000000000007
227547,Please optimize the molecule Cc1cccc(C(=O)NNC(=O)c2ccccc2-n2cccc2)c1 to have a higher LogP value.,Cc1cccc(C(=O)NNC(=O)c2ccccc2-n2cccc2)c1,2.860520000000001
175590,Modify the molecule C[C@@H](CCc1ccccc1F)C(=O)N1CCCN(C(=O)C(C)(C)C)CC1 to have a lower LogP value.,C[C@@H](CCc1ccccc1F)C(=O)N1CCCN(C(=O)C(C)(C)C)CC1,3.501400000000003
180194,Optimize the molecule C#CC[NH+]1CCC(Nc2cc(OC)cc(OC)c2)CC1 to have a lower LogP value.,C#CC[NH+]1CCC(Nc2cc(OC)cc(OC)c2)CC1,0.7961999999999998
200781,Optimize the molecule CC[C@H](C)[C@H](O)c1nccc2ccccc12 to have a higher LogP value.,CC[C@H](C)[C@H](O)c1nccc2ccccc12,3.314300000000002
30046,Please modify the molecule Cn1cnc(CNC(=O)NC2(c3cccc(Br)c3)CCC2)n1 to increase its LogP value.,Cn1cnc(CNC(=O)NC2(c3cccc(Br)c3)CCC2)n1,2.4562
224182,Modify the molecule CCN(CC(C)(C)O)C1=NS(=O)(=O)c2ccccc21 to have a lower LogP value.,CCN(CC(C)(C)O)C1=NS(=O)(=O)c2ccccc21,1.2283
11746,Modify the molecule CC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)[C@H](C)C2CC2)cc1 to have a higher LogP value.,CC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)[C@H](C)C2CC2)cc1,3.878600000000003
95809,Please modify the molecule Cc1cccc(NC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)c1Cl to increase its LogP value.,Cc1cccc(NC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)c1Cl,4.1468200000000035
19689,Please optimize the molecule C[C@H](Cc1ccccc1)OC(=O)[C@@H]1CCCN(C(=O)c2ccncc2)C1 to have a lower LogP value.,C[C@H](Cc1ccccc1)OC(=O)[C@@H]1CCCN(C(=O)c2ccncc2)C1,3.108200000000002
82976,Please modify the molecule C[C@@H]1CN(C(=O)C2=NN(c3ccccc3)C(=O)CC2)C(C)(C)CO1 to increase its LogP value.,C[C@@H]1CN(C(=O)C2=NN(c3ccccc3)C(=O)CC2)C(C)(C)CO1,2.1953000000000005
204480,Modify the molecule O=C(NCc1ccncc1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 to have a lower LogP value.,O=C(NCc1ccncc1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1,2.0216000000000003
25092,Modify the molecule COc1cccc2c(C)cc(SCC[NH+]3CCCCC3)nc12 to decrease its LogP value.,COc1cccc2c(C)cc(SCC[NH+]3CCCCC3)nc12,2.712720000000001
97060,Optimize the molecule Cc1nnc([C@@H](C)Sc2nc3ccccc3c(=O)n2-c2ccc(C)c(C)c2)o1 to have a lower LogP value.,Cc1nnc([C@@H](C)Sc2nc3ccccc3c(=O)n2-c2ccc(C)c(C)c2)o1,4.547260000000004
168232,Modify the molecule C/C(=C\C(=O)c1cccnc1)Nc1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,C/C(=C\C(=O)c1cccnc1)Nc1ccc(Oc2ccccc2)cc1,5.072500000000004
197934,Modify the molecule CSc1nc(C(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c2ccccn12 to decrease its LogP value.,CSc1nc(C(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c2ccccn12,3.4437000000000024
71624,Modify the molecule O=C([O-])c1ccc(F)c([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1 to decrease its LogP value.,O=C([O-])c1ccc(F)c([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1,2.951600000000001
10503,Please modify the molecule COCCN1CCN([C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1=O to increase its LogP value.,COCCN1CCN([C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1=O,1.2358999999999996
188665,Optimize the molecule O=C(N/N=C/c1cccc([N+](=O)[O-])c1)C(=O)Nc1cccc(Br)c1 to have a lower LogP value.,O=C(N/N=C/c1cccc([N+](=O)[O-])c1)C(=O)Nc1cccc(Br)c1,2.4461000000000004
26562,Modify the molecule Cn1ncc2c(N3CCN(CC(=O)NCc4ccc(F)cc4)CC3)ncnc21 to have a lower LogP value.,Cn1ncc2c(N3CCN(CC(=O)NCc4ccc(F)cc4)CC3)ncnc21,0.9408000000000001
99110,Modify the molecule COC(=O)c1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)cc1 to have a lower LogP value.,COC(=O)c1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)cc1,2.406600000000001
53207,Modify the molecule C[C@@H](NC(=O)NC[C@H](O)C1CCOCC1)c1ccccc1C(F)(F)F to have a higher LogP value.,C[C@@H](NC(=O)NC[C@H](O)C1CCOCC1)c1ccccc1C(F)(F)F,2.8531000000000013
128686,Please modify the molecule COc1ccc(NC(=O)[C@H](C)[NH+]2C[C@H](C)S[C@@H](C)C2)c([N+](=O)[O-])c1 to decrease its LogP value.,COc1ccc(NC(=O)[C@H](C)[NH+]2C[C@H](C)S[C@@H](C)C2)c([N+](=O)[O-])c1,1.3391
156642,Please optimize the molecule O=C(COc1cccc([N+](=O)[O-])c1)N/N=C/c1ccc(Cl)cc1Cl to have a higher LogP value.,O=C(COc1cccc([N+](=O)[O-])c1)N/N=C/c1ccc(Cl)cc1Cl,3.4307000000000016
126281,Please modify the molecule CCCC(=CC(=O)[C@H](C#N)c1ccccn1)CCC to decrease its LogP value.,CCCC(=CC(=O)[C@H](C#N)c1ccccn1)CCC,3.784480000000002
245457,Modify the molecule C[NH2+]Cc1cc(Cl)cc(Cl)c1OC/C(Cl)=C/Cl to have a lower LogP value.,C[NH2+]Cc1cc(Cl)cc(Cl)c1OC/C(Cl)=C/Cl,3.384400000000001
182324,Please modify the molecule CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1 to increase its LogP value.,CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1,4.117500000000002
124262,Optimize the molecule COc1ccc(-c2nnc(SCCS(C)(=O)=O)n2-c2ccccc2)cc1 to have a higher LogP value.,COc1ccc(-c2nnc(SCCS(C)(=O)=O)n2-c2ccccc2)cc1,3.079600000000002
139301,Modify the molecule CCc1ccc2c(COC(=O)[C@@H]3C[C@@H]3c3ccco3)cc(=O)oc2c1 to have a lower LogP value.,CCc1ccc2c(COC(=O)[C@@H]3C[C@@H]3c3ccco3)cc(=O)oc2c1,3.795300000000003
148320,Please optimize the molecule [NH3+]CCc1c(-c2ccccc2)nn(-c2ccccc2)c1[O-] to have a lower LogP value.,[NH3+]CCc1c(-c2ccccc2)nn(-c2ccccc2)c1[O-],1.3973
130038,Modify the molecule [NH3+][C@@H]1CCC[C@@H]([NH+]2CCCCC2)C1 to decrease its LogP value.,[NH3+][C@@H]1CCC[C@@H]([NH+]2CCCCC2)C1,-0.39169999999999927
176096,Modify the molecule COc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)c(Cl)c1 to increase its LogP value.,COc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)c(Cl)c1,2.9913000000000016
19332,Modify the molecule Cn1cc(NCCN2CCOCC2)cn1 to have a lower LogP value.,Cn1cc(NCCN2CCOCC2)cn1,0.16420000000000012
88195,Please optimize the molecule COc1cc(C)c(NCc2cnn(-c3ccccc3)c2)cc1OC to have a lower LogP value.,COc1cc(C)c(NCc2cnn(-c3ccccc3)c2)cc1OC,3.8100200000000024
239810,Please optimize the molecule CC[C@H]([NH2+][C@@H]1CCCn2nc(C)nc21)c1ccccc1OCC(=O)N(C)C to have a lower LogP value.,CC[C@H]([NH2+][C@@H]1CCCn2nc(C)nc21)c1ccccc1OCC(=O)N(C)C,1.6031199999999992
207021,Please optimize the molecule N#Cc1ccccc1N/C=C/C(=O)c1ccc(Br)cc1 to have a higher LogP value.,N#Cc1ccccc1N/C=C/C(=O)c1ccc(Br)cc1,4.129280000000002
75243,Optimize the molecule O=C(NC[C@H]1CCCO1)c1ccccc1NC(=O)C1CC[NH+](Cc2ccccc2)CC1 to have a lower LogP value.,O=C(NC[C@H]1CCCO1)c1ccccc1NC(=O)C1CC[NH+](Cc2ccccc2)CC1,2.029000000000001
38084,Modify the molecule C[NH2+][C@H](CC(F)(F)F)c1ccc(Br)o1 to have a lower LogP value.,C[NH2+][C@H](CC(F)(F)F)c1ccc(Br)o1,2.2288000000000006
153008,Optimize the molecule COC(=O)c1ccc(N2CCN(C(=O)Cc3ccsc3)CC2)cc1 to have a lower LogP value.,COC(=O)c1ccc(N2CCN(C(=O)Cc3ccsc3)CC2)cc1,2.426000000000001
177787,Optimize the molecule CC(=O)N1CC[NH+](C[C@@H](CC(=O)Nc2ccccc2F)C(=O)[O-])CC1 to have a higher LogP value.,CC(=O)N1CC[NH+](C[C@@H](CC(=O)Nc2ccccc2F)C(=O)[O-])CC1,-1.7325999999999968
55842,Please modify the molecule O=C(NCc1ccccc1F)Nc1ccc(S(=O)(=O)C(F)F)cc1 to increase its LogP value.,O=C(NCc1ccccc1F)Nc1ccc(S(=O)(=O)C(F)F)cc1,3.143700000000001
118006,Modify the molecule Cc1cc(C)c(OC[C@H](O)Cn2c(C)nc3ccccc32)c(C)c1 to increase its LogP value.,Cc1cc(C)c(OC[C@H](O)Cn2c(C)nc3ccccc32)c(C)c1,3.7098800000000027
229712,Please modify the molecule Cc1cccc(C)c1N1CCN(S(=O)(=O)c2cc([N+](=O)[O-])ccc2Cl)CC1 to increase its LogP value.,Cc1cccc(C)c1N1CCN(S(=O)(=O)c2cc([N+](=O)[O-])ccc2Cl)CC1,3.3759400000000026
44503,Please optimize the molecule COc1ccc2c(COC(=O)c3ccc4c(=O)n5c(nc4c3)CCC5)cc(=O)oc2c1 to have a lower LogP value.,COc1ccc2c(COC(=O)c3ccc4c(=O)n5c(nc4c3)CCC5)cc(=O)oc2c1,2.814700000000001
96849,Modify the molecule C[C@@H]1CCN(C(=O)Nc2nnc(C(F)(F)F)s2)C[C@@H]1O to decrease its LogP value.,C[C@@H]1CCN(C(=O)Nc2nnc(C(F)(F)F)s2)C[C@@H]1O,1.7914999999999996
88065,Modify the molecule CC(C)CC1(CNC(=O)N2CCC[C@@H](NS(C)(=O)=O)C2)CCCC1 to decrease its LogP value.,CC(C)CC1(CNC(=O)N2CCC[C@@H](NS(C)(=O)=O)C2)CCCC1,2.3160999999999996
58222,Optimize the molecule CC1(C)Cc2cccc(OCC(=O)Nc3nnc(C4CC4)s3)c2O1 to have a lower LogP value.,CC1(C)Cc2cccc(OCC(=O)Nc3nnc(C4CC4)s3)c2O1,3.1465000000000014
236285,Please modify the molecule Cc1cccc(C)c1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1,2.6999400000000007
109974,Please optimize the molecule Cn1ncc2c1CCC[C@H]2NC(=O)NCC(C)(C)NC(=O)OC(C)(C)C to have a lower LogP value.,Cn1ncc2c1CCC[C@H]2NC(=O)NCC(C)(C)NC(=O)OC(C)(C)C,2.3999999999999995
200318,Please optimize the molecule CC(C)C(=O)N1CCC[C@@H]1C(=O)N1C[C@H]2C[NH+]3CCCC[C@@H]3[C@@H]2C1 to have a higher LogP value.,CC(C)C(=O)N1CCC[C@@H]1C(=O)N1C[C@H]2C[NH+]3CCCC[C@@H]3[C@@H]2C1,0.15900000000000336
161945,Modify the molecule COC(=O)c1ccc(NC(=S)NC(=O)CC(C)(C)C)cc1 to have a higher LogP value.,COC(=O)c1ccc(NC(=S)NC(=O)CC(C)(C)C)cc1,2.7224000000000004
152614,Please modify the molecule CN(Cc1cccc(NN)[nH+]1)Cc1cc(Br)cs1 to increase its LogP value.,CN(Cc1cccc(NN)[nH+]1)Cc1cc(Br)cs1,2.2423
34285,Optimize the molecule CCOC(=O)N[C@H](OCC)c1ccccc1 to have a lower LogP value.,CCOC(=O)N[C@H](OCC)c1ccccc1,2.4678000000000004
83673,Modify the molecule C[C@H](CCc1ccccc1F)C(=O)N1CCC(n2cncn2)CC1 to increase its LogP value.,C[C@H](CCc1ccccc1F)C(=O)N1CCC(n2cncn2)CC1,2.8496000000000015
115652,Optimize the molecule Cc1ccc(F)cc1NC(=O)[C@@H](C(C)C)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,Cc1ccc(F)cc1NC(=O)[C@@H](C(C)C)N1C(=O)c2ccccc2C1=O,3.3934200000000025
28087,Please optimize the molecule CC(C)OC(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N(C)C2 to have a lower LogP value.,CC(C)OC(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N(C)C2,3.259500000000002
51112,Modify the molecule CN(Cc1ccc(OC(F)F)cc1)C(=O)Nc1ccc(N(C)C)cc1C(F)(F)F to have a lower LogP value.,CN(Cc1ccc(OC(F)F)cc1)C(=O)Nc1ccc(N(C)C)cc1C(F)(F)F,5.036700000000004
39255,Please optimize the molecule C[C@@H]1CCO[C@@H]1C(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2C to have a higher LogP value.,C[C@@H]1CCO[C@@H]1C(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2C,3.234300000000002
130935,Please optimize the molecule CC(C)c1nn(C)c2sc(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc12 to have a lower LogP value.,CC(C)c1nn(C)c2sc(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc12,3.9719000000000033
193721,Please optimize the molecule O=C1COc2cc(S(=O)(=O)N[C@@H]3C[C@H]3c3cccc(F)c3)c(Cl)cc2N1 to have a higher LogP value.,O=C1COc2cc(S(=O)(=O)N[C@@H]3C[C@H]3c3cccc(F)c3)c(Cl)cc2N1,2.6444
134360,Please modify the molecule C[NH+]1CCC[C@H](C(=O)NC[C@@H](C2CC2)[NH+](C)C)C1 to decrease its LogP value.,C[NH+]1CCC[C@H](C(=O)NC[C@@H](C2CC2)[NH+](C)C)C1,-2.0495999999999945
213298,Please modify the molecule CCNC(=O)N1CCN(C(=O)C(=O)NCCCc2ccccc2)CC1 to decrease its LogP value.,CCNC(=O)N1CCN(C(=O)C(=O)NCCCc2ccccc2)CC1,0.6091000000000018
202690,Modify the molecule C[C@H]1C[C@H](C)C[NH+](C[C@H](O)COc2ccccc2C#N)C1 to decrease its LogP value.,C[C@H]1C[C@H](C)C[NH+](C[C@H](O)COc2ccccc2C#N)C1,0.8587800000000004
241701,Please optimize the molecule CN(C)C(=O)c1cccnc1SCc1cccc(Br)c1 to have a higher LogP value.,CN(C)C(=O)c1cccnc1SCc1cccc(Br)c1,3.838200000000003
94509,Please modify the molecule COc1cc(C)ccc1NCC(=O)NCCc1ccccc1C to increase its LogP value.,COc1cc(C)ccc1NCC(=O)NCCc1ccccc1C,3.082840000000002
233572,Modify the molecule C[C@H](Sc1ncc(-c2ccc(F)cc2)[nH]1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1 to increase its LogP value.,C[C@H](Sc1ncc(-c2ccc(F)cc2)[nH]1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1,4.119600000000003
181104,Modify the molecule O=C1C[C@H](C(=O)N2CCOC[C@@H]2C2CC2)CN1C1CCCCCC1 to have a higher LogP value.,O=C1C[C@H](C(=O)N2CCOC[C@@H]2C2CC2)CN1C1CCCCCC1,2.1951
225871,Optimize the molecule Cc1ccc(O)cc1N/C=C1/C(=O)N(c2ccccc2Cl)C(=O)c2ccccc21 to have a lower LogP value.,Cc1ccc(O)cc1N/C=C1/C(=O)N(c2ccccc2Cl)C(=O)c2ccccc21,4.994020000000003
33405,Please modify the molecule CCN1CCO[C@H](C[NH3+])[C@@H]1c1cccc(C2CC2)c1 to decrease its LogP value.,CCN1CCO[C@H](C[NH3+])[C@@H]1c1cccc(C2CC2)c1,1.5677000000000003
17571,Optimize the molecule Cc1ccc(C)c(-n2ncc(C[NH3+])c2C(F)F)c1 to have a lower LogP value.,Cc1ccc(C)c(-n2ncc(C[NH3+])c2C(F)F)c1,2.16864
109743,Optimize the molecule CCC(=O)N1CCc2cc(S(=O)(=O)N[C@H](C(=O)N[C@H]3CCCc4ccccc43)C(C)C)ccc21 to have a lower LogP value.,CCC(=O)N1CCc2cc(S(=O)(=O)N[C@H](C(=O)N[C@H]3CCCc4ccccc43)C(C)C)ccc21,3.482400000000002
61022,Modify the molecule O=C1C[C@H](Cc2ccc(NC(=O)N[C@@H]3CCc4ccccc43)cc2)C(=O)N1 to increase its LogP value.,O=C1C[C@H](Cc2ccc(NC(=O)N[C@@H]3CCc4ccccc43)cc2)C(=O)N1,2.7008
107053,Please optimize the molecule CC(C)c1cccc2c1N[C@@H](c1ccc(O)cc1)[C@@H]1CC=C[C@H]21 to have a lower LogP value.,CC(C)c1cccc2c1N[C@@H](c1ccc(O)cc1)[C@@H]1CC=C[C@H]21,5.342100000000005
198999,Optimize the molecule Cc1cc(-c2c[nH+]c(N)cc2C)ccc1F to have a lower LogP value.,Cc1cc(-c2c[nH+]c(N)cc2C)ccc1F,2.505840000000001
150422,Please optimize the molecule O=c1c2c3nc4ccccc4nc3n(/N=C/c3cccc(Cl)c3)c2ncn1-c1ccccc1 to have a higher LogP value.,O=c1c2c3nc4ccccc4nc3n(/N=C/c3cccc(Cl)c3)c2ncn1-c1ccccc1,4.819200000000004
209382,Modify the molecule CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-] to increase its LogP value.,CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-],0.7647999999999997
20289,Please modify the molecule CCOc1cccc(NC(=O)c2ccc(C(F)(F)F)nc2[O-])c1 to decrease its LogP value.,CCOc1cccc(NC(=O)c2ccc(C(F)(F)F)nc2[O-])c1,2.825
156128,Modify the molecule CCn1nc(C)c(Br)c1COc1ccc(CCl)nc1 to have a lower LogP value.,CCn1nc(C)c(Br)c1COc1ccc(CCl)nc1,3.686720000000002
114795,Optimize the molecule O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1 to have a lower LogP value.,O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1,3.8134000000000032
98615,Modify the molecule O=C([O-])c1ccc2c(c1)S(=O)(=O)N(CC1CCCC1)C2=O to decrease its LogP value.,O=C([O-])c1ccc2c(c1)S(=O)(=O)N(CC1CCCC1)C2=O,0.3847999999999998
71494,Modify the molecule Cc1ccccc1CNC(=O)C[NH+]1CCC[C@@H]1CN1CCOCC1 to increase its LogP value.,Cc1ccccc1CNC(=O)C[NH+]1CCC[C@@H]1CN1CCOCC1,-0.009279999999997957
117379,Please optimize the molecule O=C(Nc1ccc(C(=O)N2CCCC2)cc1)N1C[C@@H]2CCCC[C@H]2C1 to have a lower LogP value.,O=C(Nc1ccc(C(=O)N2CCCC2)cc1)N1C[C@@H]2CCCC[C@H]2C1,3.576500000000003
131483,Optimize the molecule CC[NH2+]Cc1cc(Br)ccc1OC[C@@H](C)C(N)=O to have a higher LogP value.,CC[NH2+]Cc1cc(Br)ccc1OC[C@@H](C)C(N)=O,1.0326
242032,Please modify the molecule Cc1nc(C(=O)Nc2ccc(C(F)(F)F)cc2)c(C)o1 to decrease its LogP value.,Cc1nc(C(=O)Nc2ccc(C(F)(F)F)cc2)c(C)o1,3.562540000000002
183434,Please modify the molecule O=c1cc(CNc2ccc3c(c2)CCC3)c2c(ccc3ccccc32)o1 to decrease its LogP value.,O=c1cc(CNc2ccc3c(c2)CCC3)c2c(ccc3ccccc32)o1,5.047000000000004
213200,Optimize the molecule CN(C)C(=O)N1CC[C@H](O)C1 to have a higher LogP value.,CN(C)C(=O)N1CC[C@H](O)C1,-0.26539999999999986
233398,Please optimize the molecule Cc1cc(SCC(=O)N[C@H](C)C(=O)N(C)C)nc2ccccc12 to have a higher LogP value.,Cc1cc(SCC(=O)N[C@H](C)C(=O)N(C)C)nc2ccccc12,2.2282199999999994
166720,Modify the molecule CC1(C)C[C@H](NC(=O)C2CC[NH+](Cc3ccccc3F)CC2)c2ccccc2O1 to have a lower LogP value.,CC1(C)C[C@H](NC(=O)C2CC[NH+](Cc3ccccc3F)CC2)c2ccccc2O1,3.039200000000002
75798,Please modify the molecule Cn1/c(=N/C(=O)C2CCCCC2)sc2cc3c(cc21)OCCO3 to decrease its LogP value.,Cn1/c(=N/C(=O)C2CCCCC2)sc2cc3c(cc21)OCCO3,3.018600000000001
20441,Please modify the molecule C[C@H](CNC(=O)c1ccc(N)c([N+](=O)[O-])c1)Oc1ccccc1F to decrease its LogP value.,C[C@H](CNC(=O)c1ccc(N)c([N+](=O)[O-])c1)Oc1ccccc1F,2.5134000000000007
100385,Please optimize the molecule CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H](C)c1cccc(NC(C)=O)c1 to have a lower LogP value.,CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H](C)c1cccc(NC(C)=O)c1,2.8631
177864,Please modify the molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H](C)Cl)cc1 to decrease its LogP value.,Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H](C)Cl)cc1,3.490820000000002
171680,Modify the molecule Cc1cccc(C)c1Oc1ccccc1NC(=O)N[C@@H]1C=C[C@H](CO)C1 to increase its LogP value.,Cc1cccc(C)c1Oc1ccccc1NC(=O)N[C@@H]1C=C[C@H](CO)C1,4.154240000000002
241458,Please optimize the molecule CC(C)COC(=O)[C@@]12CCC(=O)N1c1ccccc1C(=O)N2CC(C)C to have a higher LogP value.,CC(C)COC(=O)[C@@]12CCC(=O)N1c1ccccc1C(=O)N2CC(C)C,2.8207000000000013
23250,Modify the molecule CC(=NNC(=O)c1ccccc1)c1cccc(N)c1 to have a lower LogP value.,CC(=NNC(=O)c1ccccc1)c1cccc(N)c1,2.4228000000000005
177618,Modify the molecule CC[C@@](C)([C@H](Cc1cc(C)nn1C)[NH2+]C)[NH+]1CCCCC1 to decrease its LogP value.,CC[C@@](C)([C@H](Cc1cc(C)nn1C)[NH2+]C)[NH+]1CCCCC1,0.07032000000000305
16987,Modify the molecule COC(=O)/C(C(C)=O)=C(\C=C\C=C\[NH+](C)C)N(C)C to have a lower LogP value.,COC(=O)/C(C(C)=O)=C(\C=C\C=C\[NH+](C)C)N(C)C,-0.22149999999999825
28031,Please optimize the molecule COCC[NH+]1[C@@H](C)CN(Cc2cccn2C)C[C@H]1C to have a higher LogP value.,COCC[NH+]1[C@@H](C)CN(Cc2cccn2C)C[C@H]1C,0.14900000000000224
169413,Please modify the molecule N#Cc1ccc(Cl)c(NC(=O)NC2(c3ccccc3F)CC2)c1 to increase its LogP value.,N#Cc1ccc(Cl)c(NC(=O)NC2(c3ccccc3F)CC2)c1,4.161580000000002
130273,Modify the molecule CC(C)[C@@](C)(O)CNC(=O)N[C@@H](C)c1nc(C(C)(C)C)no1 to increase its LogP value.,CC(C)[C@@](C)(O)CNC(=O)N[C@@H](C)c1nc(C(C)(C)C)no1,2.1343000000000005
238980,Please modify the molecule O=C(OCc1ccc([N+](=O)[O-])cc1)[C@H]1COc2ccccc2O1 to increase its LogP value.,O=C(OCc1ccc([N+](=O)[O-])cc1)[C@H]1COc2ccccc2O1,2.4780000000000006
72403,Please optimize the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21 to have a higher LogP value.,CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21,4.042400000000002
398,Please optimize the molecule N#CCCN(Cc1ccccc1)C(=S)NC(=O)c1cccc(Cl)c1 to have a lower LogP value.,N#CCCN(Cc1ccccc1)C(=S)NC(=O)c1cccc(Cl)c1,3.7705800000000025
127232,Modify the molecule CCc1n[nH]c(NC(=O)c2[nH]nc3c2C[C@@H](C)CC3)n1 to decrease its LogP value.,CCc1n[nH]c(NC(=O)c2[nH]nc3c2C[C@@H](C)CC3)n1,1.4672999999999998
158247,Modify the molecule CC[C@H](NC(=O)C[C@H]1CCCO1)c1nc(C(F)(F)F)cs1 to have a lower LogP value.,CC[C@H](NC(=O)C[C@H]1CCCO1)c1nc(C(F)(F)F)cs1,3.298300000000002
100365,Optimize the molecule O=C(CN1CSCC1=O)Nc1cc(Cl)ccc1OC[C@H]1CCCO1 to have a lower LogP value.,O=C(CN1CSCC1=O)Nc1cc(Cl)ccc1OC[C@H]1CCCO1,2.3692
231624,Modify the molecule CCc1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1 to have a higher LogP value.,CCc1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1,2.547600000000001
45320,Modify the molecule CC[C@H](NC(=O)c1ccc(-n2ccnn2)cc1)C(=O)N1CCOCC1 to have a lower LogP value.,CC[C@H](NC(=O)c1ccc(-n2ccnn2)cc1)C(=O)N1CCOCC1,0.6345000000000001
93058,Please optimize the molecule CCN(C1CC1)S(=O)(=O)c1ccc(F)c(C(=O)[O-])c1F to have a lower LogP value.,CCN(C1CC1)S(=O)(=O)c1ccc(F)c(C(=O)[O-])c1F,0.5013000000000002
174131,Modify the molecule COC(=O)CC1CC[NH+]([C@@H]2CCC[C@@H](C)C2)CC1 to decrease its LogP value.,COC(=O)CC1CC[NH+]([C@@H]2CCC[C@@H](C)C2)CC1,1.4230999999999991
202071,Modify the molecule O=C(CSc1nccn(-c2cccc(F)c2)c1=O)Nc1ccc(F)c(Cl)c1 to have a higher LogP value.,O=C(CSc1nccn(-c2cccc(F)c2)c1=O)Nc1ccc(F)c(Cl)c1,3.8949000000000025
141392,Modify the molecule COC(=O)C(C)(C)NC(=O)c1ccc(C)cc1 to increase its LogP value.,COC(=O)C(C)(C)NC(=O)c1ccc(C)cc1,1.6764199999999996
33702,Please optimize the molecule Cn1cccc1C(=O)COc1ccccc1I to have a higher LogP value.,Cn1cccc1C(=O)COc1ccccc1I,2.8914000000000017
186105,Please optimize the molecule CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CCC3)cc1 to have a higher LogP value.,CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CCC3)cc1,4.0995000000000035
109381,Modify the molecule CCOc1ccc(-c2noc(CCC(=O)NC3[C@@H](C)CCC[C@@H]3C)n2)cc1 to increase its LogP value.,CCOc1ccc(-c2noc(CCC(=O)NC3[C@@H](C)CCC[C@@H]3C)n2)cc1,4.0088000000000035
109146,Modify the molecule CCCc1nnc(NC(=O)Cn2cnc3ccccc3c2=O)s1 to have a higher LogP value.,CCCc1nnc(NC(=O)Cn2cnc3ccccc3c2=O)s1,1.8392000000000002
163524,Please modify the molecule Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1 to increase its LogP value.,Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1,2.942140000000001
90885,Modify the molecule CN(C)c1c(Cl)cccc1NC(=O)N1CCCN(c2nccs2)CC1 to decrease its LogP value.,CN(C)c1c(Cl)cccc1NC(=O)N1CCCN(c2nccs2)CC1,3.6067000000000027
204370,Modify the molecule CCOC(=O)C1CC[NH+]([C@@H](c2ccccc2)c2sc3nc(CC)nn3c2O)CC1 to increase its LogP value.,CCOC(=O)C1CC[NH+]([C@@H](c2ccccc2)c2sc3nc(CC)nn3c2O)CC1,2.0061999999999998
94100,Modify the molecule CN(C)C(=O)c1cccc(C(=O)N[C@@H](CO)CC(C)(C)C)c1 to have a higher LogP value.,CN(C)C(=O)c1cccc(C(=O)N[C@@H](CO)CC(C)(C)C)c1,1.9152999999999993
102489,Please modify the molecule Cc1cccn2c(=O)c(C(=O)NC[C@H](C)CCO)cnc12 to decrease its LogP value.,Cc1cccn2c(=O)c(C(=O)NC[C@H](C)CCO)cnc12,0.7512199999999993
197738,Modify the molecule O=C(Cc1ccc(Cl)cc1)NC[C@H](O)c1cccc2ccccc12 to have a lower LogP value.,O=C(Cc1ccc(Cl)cc1)NC[C@H](O)c1cccc2ccccc12,3.885500000000002
246824,Please optimize the molecule COC(=O)CCC[NH+]1CCC(CS(N)(=O)=O)CC1 to have a lower LogP value.,COC(=O)CCC[NH+]1CCC(CS(N)(=O)=O)CC1,-1.4769999999999968
43939,Modify the molecule C[C@H](OCc1cc(F)ccc1N)c1ccccc1 to increase its LogP value.,C[C@H](OCc1cc(F)ccc1N)c1ccccc1,3.6857000000000015
216587,Please optimize the molecule CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1cncc(C)c1 to have a lower LogP value.,CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1cncc(C)c1,2.29422
77230,Please modify the molecule C[NH+]1CCCCC[C@@H]1C(=O)NCc1ccc(O)cc1 to increase its LogP value.,C[NH+]1CCCCC[C@@H]1C(=O)NCc1ccc(O)cc1,0.4656999999999999
246573,Please modify the molecule Cc1nc(C2CC[NH+](CC(C)(C)C)CC2)n[nH]1 to increase its LogP value.,Cc1nc(C2CC[NH+](CC(C)(C)C)CC2)n[nH]1,0.9215199999999999
37746,Please modify the molecule CC[C@H](N[C@H](C)c1nc2ccccc2n1C(F)F)c1ccncc1 to decrease its LogP value.,CC[C@H](N[C@H](C)c1nc2ccccc2n1C(F)F)c1ccncc1,4.628300000000004
176872,Please optimize the molecule COc1ccccc1N1C(=O)/C(=C\C=C\c2ccccc2)C(=O)N(c2ccccc2)C1=S to have a higher LogP value.,COc1ccccc1N1C(=O)/C(=C\C=C\c2ccccc2)C(=O)N(c2ccccc2)C1=S,4.999700000000003
242852,Modify the molecule O=C([O-])C1CN(c2cnccn2)C1 to increase its LogP value.,O=C([O-])C1CN(c2cnccn2)C1,-1.3373000000000004
144474,Modify the molecule O=C(NCc1ccc(F)cc1)Nc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C(NCc1ccc(F)cc1)Nc1cccc(C(F)(F)F)c1,4.166200000000002
197095,Please optimize the molecule CCCNC(=O)NNC(=O)COc1cccc(C)c1 to have a higher LogP value.,CCCNC(=O)NNC(=O)COc1cccc(C)c1,1.11422
38725,Modify the molecule NC(=O)c1ccc(N2CCCCC2)c(NC(=O)Cc2ccccc2)c1 to have a higher LogP value.,NC(=O)c1ccc(N2CCCCC2)c(NC(=O)Cc2ccccc2)c1,2.9570000000000016
19004,Please optimize the molecule CC(C)CN(C)C(=O)N[C@@H](C)c1ccc(-n2cncn2)cc1 to have a higher LogP value.,CC(C)CN(C)C(=O)N[C@@H](C)c1ccc(-n2cncn2)cc1,2.625700000000001
221445,Modify the molecule CCOc1ccc2c(C(=O)NCC3CC3)cc(=O)oc2c1 to decrease its LogP value.,CCOc1ccc2c(C(=O)NCC3CC3)cc(=O)oc2c1,2.3315
61805,Modify the molecule Cc1ccc(NC(=O)N2CCc3[nH]c4ccccc4c3C2)cc1C(N)=O to have a lower LogP value.,Cc1ccc(NC(=O)N2CCc3[nH]c4ccccc4c3C2)cc1C(N)=O,3.16542
241852,Please modify the molecule COc1ccccc1NC(=[NH2+])SCc1cccc(C(N)=O)c1 to increase its LogP value.,COc1ccccc1NC(=[NH2+])SCc1cccc(C(N)=O)c1,1.2545000000000002
197353,Modify the molecule N#Cc1cnn(CCN2CCO[C@H](CNc3cccn[nH+]3)C2)c1 to have a lower LogP value.,N#Cc1cnn(CCN2CCO[C@H](CNc3cccn[nH+]3)C2)c1,-0.2232199999999993
293,Modify the molecule Cc1cccc(C)c1NC(=O)C[NH+]1CCC(OCc2ccc(F)cc2)CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)C[NH+]1CCC(OCc2ccc(F)cc2)CC1,2.6451400000000005
226556,Please optimize the molecule COC(=O)c1ccc(CN2CCN(CCn3cc[nH+]c3C)CC2)cc1 to have a higher LogP value.,COC(=O)c1ccc(CN2CCN(CCn3cc[nH+]c3C)CC2)cc1,1.2150199999999998
60892,Modify the molecule CC(C)c1nc(CNC(=O)[C@H]2Cc3cc(F)ccc3O2)cs1 to increase its LogP value.,CC(C)c1nc(CNC(=O)[C@H]2Cc3cc(F)ccc3O2)cs1,3.025500000000001
148398,Modify the molecule C[C@H](NC(=O)NC[C@@H]1CC[NH+](C2CC2)C1)C(=O)N1CCCCC1 to have a lower LogP value.,C[C@H](NC(=O)NC[C@@H]1CC[NH+](C2CC2)C1)C(=O)N1CCCCC1,-0.2461999999999971
148875,Please modify the molecule O=C(c1ccn(-c2ccc(Cl)cc2Cl)n1)N1CCCCC1 to increase its LogP value.,O=C(c1ccn(-c2ccc(Cl)cc2Cl)n1)N1CCCCC1,3.805200000000003
27089,Optimize the molecule COc1ccc(C[NH+]2CCN(CCO)CC2)cc1 to have a lower LogP value.,COc1ccc(C[NH+]2CCN(CCO)CC2)cc1,-0.6119999999999983
171203,Please modify the molecule C[C@H](NC(=O)C1CCCCC1)C(=O)N1CCO[C@@H](c2ccccc2F)C1 to decrease its LogP value.,C[C@H](NC(=O)C1CCCCC1)C(=O)N1CCO[C@@H](c2ccccc2F)C1,2.810600000000001
69351,Modify the molecule Cc1nc(S[C@H](C)C(=O)NC(N)=O)c(C#N)c(C)c1C to increase its LogP value.,Cc1nc(S[C@H](C)C(=O)NC(N)=O)c(C#N)c(C)c1C,1.5540400000000003
134254,Modify the molecule CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12 to increase its LogP value.,CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12,2.31592
122778,Optimize the molecule CC[C@H](NC(=O)C(=O)c1c(C)nn(-c2ccccc2)c1C)c1ccc(Cl)cc1 to have a lower LogP value.,CC[C@H](NC(=O)C(=O)c1c(C)nn(-c2ccccc2)c1C)c1ccc(Cl)cc1,4.592740000000004
100995,Modify the molecule CC[NH2+][C@H](CSCC)[C@@H]1CCC[C@H](S(C)(=O)=O)C1 to have a higher LogP value.,CC[NH2+][C@H](CSCC)[C@@H]1CCC[C@H](S(C)(=O)=O)C1,1.2948000000000004
223286,Modify the molecule C[NH+](C)[C@@H](CNC(=O)N[C@@H](CO)c1ccccc1)c1cccc(F)c1 to have a higher LogP value.,C[NH+](C)[C@@H](CNC(=O)N[C@@H](CO)c1ccccc1)c1cccc(F)c1,1.044100000000001
244385,Modify the molecule Cc1ccc(NC(=O)C(=O)N2CSC[C@H]2C(=O)[O-])cc1 to have a lower LogP value.,Cc1ccc(NC(=O)C(=O)N2CSC[C@H]2C(=O)[O-])cc1,-0.4150800000000001
195437,Modify the molecule C[C@H]1CCN(CCCN2C(=O)NC(C)(C)C2=O)c2ccccc21 to increase its LogP value.,C[C@H]1CCN(CCCN2C(=O)NC(C)(C)C2=O)c2ccccc21,2.720700000000001
152366,Please modify the molecule O=C([O-])Cn1nc(-c2ccco2)ccc1=O to increase its LogP value.,O=C([O-])Cn1nc(-c2ccco2)ccc1=O,-0.7468000000000004
20734,Please optimize the molecule Cc1cc(O)c(C(=O)c2ccccc2)cc1Cl to have a lower LogP value.,Cc1cc(O)c(C(=O)c2ccccc2)cc1Cl,3.585020000000001
75953,Modify the molecule O=C(CO)Nc1cccc([N-]S(=O)(=O)c2ccccc2Cl)c1 to have a lower LogP value.,O=C(CO)Nc1cccc([N-]S(=O)(=O)c2ccccc2Cl)c1,2.664900000000001
4194,Modify the molecule Cc1ccc(CC(=O)NCC2(c3ccccc3Cl)CC2)cc1O to have a lower LogP value.,Cc1ccc(CC(=O)NCC2(c3ccccc3Cl)CC2)cc1O,3.7445200000000027
185511,Please modify the molecule C[C@H]1CCC[C@H](NC(=O)CSCCn2c(=O)oc3cccnc32)[C@@H]1C to decrease its LogP value.,C[C@H]1CCC[C@H](NC(=O)CSCCn2c(=O)oc3cccnc32)[C@@H]1C,2.6636000000000006
78829,Modify the molecule Cc1cc(CN(C)C(=O)c2cnn(-c3ccc(Cl)cc3)c2)no1 to increase its LogP value.,Cc1cc(CN(C)C(=O)c2cnn(-c3ccc(Cl)cc3)c2)no1,3.0943200000000015
206629,Modify the molecule COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O to have a higher LogP value.,COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O,0.4949000000000004
101495,Modify the molecule CC[C@H]1CN(C[C@H](O)c2ccc(F)cc2F)CC[NH+]1C[C@@H](C)O to have a higher LogP value.,CC[C@H]1CN(C[C@H](O)c2ccc(F)cc2F)CC[NH+]1C[C@@H](C)O,0.3580999999999999
58087,Please optimize the molecule O=[S@](Cc1nnc(Cc2ccccc2)o1)c1ccc2ccccc2c1 to have a higher LogP value.,O=[S@](Cc1nnc(Cc2ccccc2)o1)c1ccc2ccccc2c1,4.121400000000003
153061,Optimize the molecule Cc1ccccc1C[C@H]([NH3+])[C@H]1CSCCO1 to have a higher LogP value.,Cc1ccccc1C[C@H]([NH3+])[C@H]1CSCCO1,1.2800200000000002
6452,Optimize the molecule Cc1nc(CC(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)cs1 to have a higher LogP value.,Cc1nc(CC(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)cs1,4.465320000000004
14254,Optimize the molecule CCOc1cc2c(cc1NC(=O)CCc1c(C)[nH]c(=O)[nH]c1=O)O[C@@H](C)C2 to have a higher LogP value.,CCOc1cc2c(cc1NC(=O)CCc1c(C)[nH]c(=O)[nH]c1=O)O[C@@H](C)C2,1.66502
1188,Please modify the molecule Fc1cccc(Oc2nc(-c3ccncc3)nc3c2CCC3)c1F to decrease its LogP value.,Fc1cccc(Oc2nc(-c3ccncc3)nc3c2CCC3)c1F,4.097800000000002
150617,Please modify the molecule Cn1c(=O)oc2cc(NC(=O)NCc3cccc(C#N)c3)ccc21 to increase its LogP value.,Cn1c(=O)oc2cc(NC(=O)NCc3cccc(C#N)c3)ccc21,2.3248800000000003
98356,Optimize the molecule Cc1cc(C)c2c(NC[C@H]3CCCN(C(=O)C4CC4)C3)ncnc2n1 to have a higher LogP value.,Cc1cc(C)c2c(NC[C@H]3CCCN(C(=O)C4CC4)C3)ncnc2n1,2.702140000000001
194093,Optimize the molecule COc1ccc(-n2nc3cc(C)c(NC(=S)NC(=O)c4ccc5c(c4)OCO5)cc3n2)cc1Cl to have a lower LogP value.,COc1ccc(-n2nc3cc(C)c(NC(=S)NC(=O)c4ccc5c(c4)OCO5)cc3n2)cc1Cl,4.246420000000002
238253,Modify the molecule C[NH+](CC(=O)Nc1cccnc1)Cc1ccc(F)c(F)c1 to decrease its LogP value.,C[NH+](CC(=O)Nc1cccnc1)Cc1ccc(F)c(F)c1,1.0132
45776,Modify the molecule N#Cc1ccc(CNS(=O)(=O)c2ccc(C(=O)NCC(F)(F)F)cc2)cc1 to have a lower LogP value.,N#Cc1ccc(CNS(=O)(=O)c2ccc(C(=O)NCC(F)(F)F)cc2)cc1,2.3288800000000007
144128,Please modify the molecule CNc1ccc2nc(CC[NH+](C)C)[nH]c2n1 to increase its LogP value.,CNc1ccc2nc(CC[NH+](C)C)[nH]c2n1,-0.3133999999999994
60292,Modify the molecule Cc1nc(-c2nc[nH]n2)sc1C(=O)OCCc1c(C)n[nH]c1C to have a higher LogP value.,Cc1nc(-c2nc[nH]n2)sc1C(=O)OCCc1c(C)n[nH]c1C,1.9760599999999997
173451,Please optimize the molecule CCn1ccc(=O)nc1SCC(=O)NC(C)(C)CC to have a higher LogP value.,CCn1ccc(=O)nc1SCC(=O)NC(C)(C)CC,1.6600999999999995
69629,Modify the molecule COC(=O)c1c(C)[nH]c(C(=O)NCc2nc(-c3ccccc3)no2)c1C to decrease its LogP value.,COC(=O)c1c(C)[nH]c(C(=O)NCc2nc(-c3ccccc3)no2)c1C,2.3981400000000006
202830,Please modify the molecule COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@@H](C)C(=O)NCCC3=CCCCC3)CC1)C=2 to decrease its LogP value.,COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@@H](C)C(=O)NCCC3=CCCCC3)CC1)C=2,0.43950000000000267
206191,Modify the molecule COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1 to have a lower LogP value.,COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1,4.026640000000003
94351,Please modify the molecule CC[C@](C)([C@@H](NC)c1c(C)cc[nH+]c1N)[NH+]1CCCC1 to decrease its LogP value.,CC[C@](C)([C@@H](NC)c1c(C)cc[nH+]c1N)[NH+]1CCCC1,0.4992200000000016
73752,Please modify the molecule COCCOC(=O)/C(C#N)=C\c1ccc(Cl)cc1Cl to decrease its LogP value.,COCCOC(=O)/C(C#N)=C\c1ccc(Cl)cc1Cl,3.0899800000000015
127346,Optimize the molecule c1ccc([C@@H]2C[C@H](c3ccco3)n3cnnc3N2)cc1 to have a lower LogP value.,c1ccc([C@@H]2C[C@H](c3ccco3)n3cnnc3N2)cc1,3.0174000000000003
232654,Please optimize the molecule C[C@@H]([C@@H](C)O)[NH+](C)C[C@@H](C)C(=O)[O-] to have a lower LogP value.,C[C@@H]([C@@H](C)O)[NH+](C)C[C@@H](C)C(=O)[O-],-2.343599999999997
195408,Please optimize the molecule O=[N+]([O-])c1cccc(N[C@@H]2CCCc3cccnc32)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(N[C@@H]2CCCc3cccnc32)c1,3.479300000000001
217389,Please modify the molecule COCCN1C(=O)c2oc3cc(C)c(Cl)cc3c(=O)c2[C@@H]1c1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,COCCN1C(=O)c2oc3cc(C)c(Cl)cc3c(=O)c2[C@@H]1c1ccc([N+](=O)[O-])cc1,3.8546200000000024
237284,Optimize the molecule O=C(NC[C@@H](c1cccnc1)[NH+]1CCN(c2ccccc2)CC1)C(=O)Nc1cccc(F)c1 to have a higher LogP value.,O=C(NC[C@@H](c1cccnc1)[NH+]1CCN(c2ccccc2)CC1)C(=O)Nc1cccc(F)c1,1.4218000000000006
14081,Modify the molecule CC(C)[C@@H]1CSC[C@@H](C(=O)[O-])[NH2+]1 to have a higher LogP value.,CC(C)[C@@H]1CSC[C@@H](C(=O)[O-])[NH2+]1,-1.5602999999999974
73673,Modify the molecule COC(=O)c1c(OC[C@H]2CCCCO2)cc(=O)n2c1CC[NH+](Cc1c(F)cccc1F)CC2 to decrease its LogP value.,COC(=O)c1c(OC[C@H]2CCCCO2)cc(=O)n2c1CC[NH+](Cc1c(F)cccc1F)CC2,1.5022000000000004
11596,Optimize the molecule CN(Cc1ccccc1)C(=O)CCNC(=O)N1CCC[C@@H]2CCC[C@@H]21 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)CCNC(=O)N1CCC[C@@H]2CCC[C@@H]21,3.0092000000000017
164862,Modify the molecule Cc1cccc(CC(=O)N2CCN(c3nnc(SCC(N)=O)s3)CC2)c1 to increase its LogP value.,Cc1cccc(CC(=O)N2CCN(c3nnc(SCC(N)=O)s3)CC2)c1,1.3152199999999996
8406,Modify the molecule Cc1ccc(C)n1NC(=O)c1ccc(N)c(F)c1 to have a higher LogP value.,Cc1ccc(C)n1NC(=O)c1ccc(N)c(F)c1,2.21014
244284,Please modify the molecule O=C(c1ccncc1)N(Cc1ccco1)Cc1cccs1 to decrease its LogP value.,O=C(c1ccncc1)N(Cc1ccco1)Cc1cccs1,3.578700000000002
83043,Modify the molecule C[C@@H](O)C[C@@H](C)CNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCCC1 to increase its LogP value.,C[C@@H](O)C[C@@H](C)CNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCCC1,2.7219000000000007
178226,Optimize the molecule COCCN1C(=O)NC(=N)[C@@]1(C)C1CC1 to have a higher LogP value.,COCCN1C(=O)NC(=N)[C@@]1(C)C1CC1,0.80397
120071,Modify the molecule Cc1ccc(NC(=O)CN2CCN(Cc3cccc(Cl)c3)S2(=O)=O)cc1 to increase its LogP value.,Cc1ccc(NC(=O)CN2CCN(Cc3cccc(Cl)c3)S2(=O)=O)cc1,2.6495200000000008
205534,Please modify the molecule Cc1ccccc1C(=O)N1CCN(c2cccc(Cl)c2C)C(=O)[C@@H]1C to decrease its LogP value.,Cc1ccccc1C(=O)N1CCN(c2cccc(Cl)c2C)C(=O)[C@@H]1C,3.8343400000000027
6416,Optimize the molecule Cc1nnc(Nc2ccccc2)o1 to have a lower LogP value.,Cc1nnc(Nc2ccccc2)o1,2.12162
127018,Please optimize the molecule O=C(CN(C1CCCCC1)S(=O)(=O)c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1 to have a lower LogP value.,O=C(CN(C1CCCCC1)S(=O)(=O)c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1,4.0122000000000035
51459,Modify the molecule COc1ccccc1[C@@H]1C[NH+](CC(=O)N[C@@H](c2ccco2)C(F)(F)F)Cc2ccccc2O1 to decrease its LogP value.,COc1ccccc1[C@@H]1C[NH+](CC(=O)N[C@@H](c2ccco2)C(F)(F)F)Cc2ccccc2O1,3.226600000000002
157506,Modify the molecule C[C@@]1(c2ccc(F)cc2)NC(=O)N(CN2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)C1=O to increase its LogP value.,C[C@@]1(c2ccc(F)cc2)NC(=O)N(CN2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)C1=O,2.709900000000001
183099,Please modify the molecule CCN(Cc1ccccn1)CN1C(=O)N[C@@H](Cc2ccccc2)C1=O to decrease its LogP value.,CCN(Cc1ccccn1)CN1C(=O)N[C@@H](Cc2ccccc2)C1=O,2.0241
199133,Optimize the molecule O=C(N/N=C/c1c(F)cccc1Cl)c1cc(-c2ccc(Br)cc2)n[nH]1 to have a lower LogP value.,O=C(N/N=C/c1c(F)cccc1Cl)c1cc(-c2ccc(Br)cc2)n[nH]1,4.395600000000002
24533,Please modify the molecule Cn1c(SCc2cccc(Cl)c2)nnc1[C@@H]1COc2ccccc2O1 to increase its LogP value.,Cn1c(SCc2cccc(Cl)c2)nnc1[C@@H]1COc2ccccc2O1,4.273300000000003
200460,Optimize the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2ccc(S(=O)(=O)[N-]c3ccncc3)cc2)C1 to have a higher LogP value.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2ccc(S(=O)(=O)[N-]c3ccncc3)cc2)C1,1.2711000000000006
86620,Please optimize the molecule Cc1cccc(C(=O)NCCNC(=O)c2ccc(C(N)=O)cc2)c1 to have a lower LogP value.,Cc1cccc(C(=O)NCCNC(=O)c2ccc(C(N)=O)cc2)c1,1.25372
116972,Please modify the molecule Cn1c([C@@H]2CCCN2C(=O)c2ccc3ncsc3c2)nc2ccccc21 to increase its LogP value.,Cn1c([C@@H]2CCCN2C(=O)c2ccc3ncsc3c2)nc2ccccc21,4.160300000000003
115203,Please modify the molecule CCO[C@H]1C[NH+](C)C[C@@H]1NC(=O)c1ccc(C)c(N2CCNC2=O)c1 to decrease its LogP value.,CCO[C@H]1C[NH+](C)C[C@@H]1NC(=O)c1ccc(C)c(N2CCNC2=O)c1,-0.44357999999999587
230934,Modify the molecule COc1ccccc1NC(=O)Nc1nnc(N2C[C@@H](C)C[C@H](C)C2)s1 to decrease its LogP value.,COc1ccccc1NC(=O)Nc1nnc(N2C[C@@H](C)C[C@H](C)C2)s1,3.6730000000000027
172291,Optimize the molecule COc1ccc(OC)c([C@H]2CCCN2CN2C(=O)C(=O)c3ccccc32)c1 to have a higher LogP value.,COc1ccc(OC)c([C@H]2CCCN2CN2C(=O)C(=O)c3ccccc32)c1,3.027700000000002
76218,Optimize the molecule CC(C)CCNC(=O)c1cc2c(=O)n3ccccc3nc2n1C to have a lower LogP value.,CC(C)CCNC(=O)c1cc2c(=O)n3ccccc3nc2n1C,1.9621
110928,Optimize the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)c1ccc(C(F)(F)F)cc1 to have a higher LogP value.,CN(Cc1ccccc1C(F)(F)F)C(=O)c1ccc(C(F)(F)F)cc1,4.996400000000003
13394,Please modify the molecule COc1cc([C@H](C)[NH2+]C2C[C@@H](C)O[C@H](C)C2)ccc1SC(F)F to increase its LogP value.,COc1cc([C@H](C)[NH2+]C2C[C@@H](C)O[C@H](C)C2)ccc1SC(F)F,3.5903000000000027
85431,Please modify the molecule CS[C@H]1CC[C@@H](NC(=O)c2cnn(-c3ccc(C)cc3)c2C(C)C)C1 to increase its LogP value.,CS[C@H]1CC[C@@H](NC(=O)c2cnn(-c3ccc(C)cc3)c2C(C)C)C1,4.318020000000003
164883,Modify the molecule C[C@@H]1C[C@@H](C)CN(C(=O)Cc2csc(N3CCCC3=O)n2)C1 to have a higher LogP value.,C[C@@H]1C[C@@H](C)CN(C(=O)Cc2csc(N3CCCC3=O)n2)C1,2.3169000000000004
176826,Please optimize the molecule CCCC[C@H](C(=O)[O-])[C@H](C)O to have a higher LogP value.,CCCC[C@H](C(=O)[O-])[C@H](C)O,-0.07650000000000018
37578,Optimize the molecule C=CCNC(=O)C(=O)Nc1c2c(nn1-c1ccc(F)cc1)CS(=O)(=O)C2 to have a higher LogP value.,C=CCNC(=O)C(=O)Nc1c2c(nn1-c1ccc(F)cc1)CS(=O)(=O)C2,0.6804999999999997
172957,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H](OCC[NH3+])C1 to have a higher LogP value.,CS(=O)(=O)[C@@H]1CCC[C@@H](OCC[NH3+])C1,-0.39929999999999843
229455,Please modify the molecule Cc1noc(CNc2ccn(-c3ccc(Cl)cc3Cl)n2)n1 to increase its LogP value.,Cc1noc(CNc2ccn(-c3ccc(Cl)cc3Cl)n2)n1,3.4826200000000016
121080,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1 to increase its LogP value.,COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1,3.644000000000002
127496,Please modify the molecule O=C([O-])[C@H]1CCCN1C(=O)Cc1csc(-c2cccs2)n1 to increase its LogP value.,O=C([O-])[C@H]1CCCN1C(=O)Cc1csc(-c2cccs2)n1,1.1549999999999998
33611,Optimize the molecule Cc1c(C)c2ccc(OCC(=O)NCCC[NH+](C)C)c(C)c2oc1=O to have a higher LogP value.,Cc1c(C)c2ccc(OCC(=O)NCCC[NH+](C)C)c(C)c2oc1=O,0.7478600000000013
147980,Optimize the molecule C[NH2+][C@H]1CCC[C@H]([NH+](C)CCCOC)C1 to have a lower LogP value.,C[NH2+][C@H]1CCC[C@H]([NH+](C)CCCOC)C1,-0.957999999999996
140056,Optimize the molecule CC[C@@](C)(C[NH3+])[C@H](O)c1ccccn1 to have a higher LogP value.,CC[C@@](C)(C[NH3+])[C@H](O)c1ccccn1,0.7731999999999997
100676,Optimize the molecule N#CCN(C[C@H]1CCOC1)C1CCCC1 to have a higher LogP value.,N#CCN(C[C@H]1CCOC1)C1CCCC1,1.79108
90960,Modify the molecule C[C@@H]1CN([C@@H]2CCCc3ccccc32)CCO1 to have a lower LogP value.,C[C@@H]1CN([C@@H]2CCCc3ccccc32)CCO1,2.784700000000001
82432,Please modify the molecule CCN(Cc1cccc(Cl)c1)C(=O)NCCc1cc(F)cc2c1OCOC2 to decrease its LogP value.,CCN(Cc1cccc(Cl)c1)C(=O)NCCc1cc(F)cc2c1OCOC2,4.119800000000003
141295,Modify the molecule CCc1nsc(NCc2ccccc2CN2CCOCC2)n1 to have a lower LogP value.,CCc1nsc(NCc2ccccc2CN2CCOCC2)n1,2.5448000000000004
134618,Please modify the molecule Cc1nnc2sc(-c3ccc(CNC(=O)COc4ccc(Br)cc4)cc3)nn12 to increase its LogP value.,Cc1nnc2sc(-c3ccc(CNC(=O)COc4ccc(Br)cc4)cc3)nn12,3.618920000000002
70967,Optimize the molecule Cc1nc(C)c(C(=O)NCc2cccc(NC(=O)CC(C)C)c2)o1 to have a higher LogP value.,Cc1nc(C)c(C(=O)NCc2cccc(NC(=O)CC(C)C)c2)o1,3.2060400000000016
83274,Please modify the molecule Cc1ncccc1N1C(=O)[C@H](C2CC2)NC(=O)[C@H]1C to decrease its LogP value.,Cc1ncccc1N1C(=O)[C@H](C2CC2)NC(=O)[C@H]1C,1.01992
204780,Modify the molecule COc1cc(C(=O)N/N=C2/C=C(C)CC2)ccc1OCCC(C)C to have a lower LogP value.,COc1cc(C(=O)N/N=C2/C=C(C)CC2)ccc1OCCC(C)C,3.9460000000000033
180003,Optimize the molecule CCCCn1c([S@](=O)[C@@H](C)C(=O)Nc2cccc(C)c2C)n[nH]c1=O to have a higher LogP value.,CCCCn1c([S@](=O)[C@@H](C)C(=O)Nc2cccc(C)c2C)n[nH]c1=O,2.12314
4014,Modify the molecule CCC[C@@](C)(CO)NC(=O)Nc1ccc(N2CCc3sccc3C2)cc1 to decrease its LogP value.,CCC[C@@](C)(CO)NC(=O)Nc1ccc(N2CCc3sccc3C2)cc1,3.9834000000000023
125198,Modify the molecule CCn1ccnc(N2CCN(C(=O)C(=O)N3CCCC3)CC2)c1=O to have a lower LogP value.,CCn1ccnc(N2CCN(C(=O)C(=O)N3CCCC3)CC2)c1=O,-0.4657999999999982
165884,Please modify the molecule Cc1ccc([C@H](C)N(C)C(=O)c2sc(C)nc2C)cc1 to decrease its LogP value.,Cc1ccc([C@H](C)N(C)C(=O)c2sc(C)nc2C)cc1,3.9015600000000035
34906,Modify the molecule Cn1c(=O)[nH]c(=O)c2c1nc(SCC(=O)Nc1ccccc1)n2Cc1cccc(Cl)c1 to have a lower LogP value.,Cn1c(=O)[nH]c(=O)c2c1nc(SCC(=O)Nc1ccccc1)n2Cc1cccc(Cl)c1,2.8558000000000003
205766,Please optimize the molecule O=C(Cc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1)NCC(F)(F)F to have a higher LogP value.,O=C(Cc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1)NCC(F)(F)F,4.570400000000002
243910,Please optimize the molecule C#CC[NH+](CC(=O)[O-])[C@H]1CCO[C@@H](C(C)C)C1 to have a higher LogP value.,C#CC[NH+](CC(=O)[O-])[C@H]1CCO[C@@H](C(C)C)C1,-1.5419999999999963
39221,Please modify the molecule COc1ccc(-c2nn(-c3ccccc3)cc2CCl)cc1 to increase its LogP value.,COc1ccc(-c2nn(-c3ccccc3)cc2CCl)cc1,4.286700000000003
101313,Modify the molecule CCCCN(C[C@@H]1C=c2ccc(C)cc2=[NH+]C1=O)C(=O)c1ccc(Cl)cc1 to decrease its LogP value.,CCCCN(C[C@@H]1C=c2ccc(C)cc2=[NH+]C1=O)C(=O)c1ccc(Cl)cc1,1.2280199999999997
148886,Optimize the molecule CC(C)C[C@H](C#N)NC(=O)Cc1ccc(Cl)cc1 to have a lower LogP value.,CC(C)C[C@H](C#N)NC(=O)Cc1ccc(Cl)cc1,2.936980000000001
27113,Optimize the molecule C[C@]1(/C=N/O)CS/C(=N/O)S1 to have a lower LogP value.,C[C@]1(/C=N/O)CS/C(=N/O)S1,1.4303
190409,Please modify the molecule C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3c(c2)CCC3)CC1 to decrease its LogP value.,C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3c(c2)CCC3)CC1,3.420300000000002
149516,Modify the molecule O=c1nc(C(Cl)(Cl)Cl)nc2ccccn12 to increase its LogP value.,O=c1nc(C(Cl)(Cl)Cl)nc2ccccn12,1.9161999999999995
2390,Optimize the molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 to have a lower LogP value.,CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1,1.6004999999999996
15905,Please modify the molecule CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1 to decrease its LogP value.,CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1,3.300620000000002
216432,Modify the molecule C[C@@H]1C[C@H]1C(=O)Nc1ccc(C(=O)NCc2ccccc2CO)cc1 to decrease its LogP value.,C[C@@H]1C[C@H]1C(=O)Nc1ccc(C(=O)NCc2ccccc2CO)cc1,2.703400000000001
31297,Modify the molecule CC(C)(C)[C@@H](NCc1cc(=O)n2ccsc2[nH+]1)c1cccs1 to increase its LogP value.,CC(C)(C)[C@@H](NCc1cc(=O)n2ccsc2[nH+]1)c1cccs1,3.1136000000000017
199264,Modify the molecule CC[C@H]1CN(Cc2cnc(C3CCC3)s2)CCS1 to increase its LogP value.,CC[C@H]1CN(Cc2cnc(C3CCC3)s2)CCS1,3.738000000000003
34240,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)[C@H]2COc3ccccc3C2)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)[C@H]2COc3ccccc3C2)CC1,3.115000000000002
226719,Please modify the molecule C[C@H]([NH2+]Cc1cccc2cccnc12)c1ccc(F)c(F)c1 to increase its LogP value.,C[C@H]([NH2+]Cc1cccc2cccnc12)c1ccc(F)c(F)c1,3.337600000000002
60048,Optimize the molecule Cc1ccc(OCC(=O)NC2CCCCCC2)c(C[NH3+])n1 to have a higher LogP value.,Cc1ccc(OCC(=O)NC2CCCCCC2)c(C[NH3+])n1,1.3497199999999994
247387,Modify the molecule CSc1ccccc1C(=O)NCc1ccc(-c2csc(C)n2)cc1 to increase its LogP value.,CSc1ccccc1C(=O)NCc1ccc(-c2csc(C)n2)cc1,4.770420000000004
243299,Please optimize the molecule CC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Br)c(F)c1 to have a lower LogP value.,CC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Br)c(F)c1,3.1587200000000015
69081,Please modify the molecule O=C(Cc1ccc(-n2cnnn2)cc1)N1CCc2ccc([N+](=O)[O-])cc2C1 to decrease its LogP value.,O=C(Cc1ccc(-n2cnnn2)cc1)N1CCc2ccc([N+](=O)[O-])cc2C1,1.6979
101507,Modify the molecule Cc1nc(C2CCN(C(=O)NC[C@H](C(C)C)N3CC[NH+](C)CC3)CC2)no1 to increase its LogP value.,Cc1nc(C2CCN(C(=O)NC[C@H](C(C)C)N3CC[NH+](C)CC3)CC2)no1,0.12192000000000291
144364,Modify the molecule CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F to increase its LogP value.,CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F,2.2663
153714,Modify the molecule Cc1c(N2C(=O)[C@@H]3[C@H]4CCC[NH+]4[C@]4(C(=O)Nc5c(Cl)cccc54)[C@@H]3C2=O)cccc1[N+](=O)[O-] to have a higher LogP value.,Cc1c(N2C(=O)[C@@H]3[C@H]4CCC[NH+]4[C@]4(C(=O)Nc5c(Cl)cccc54)[C@@H]3C2=O)cccc1[N+](=O)[O-],1.5707200000000001
191090,Please optimize the molecule CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1 to have a lower LogP value.,CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1,-0.8653599999999941
247646,Modify the molecule CCn1cc([C@H](C)NC(=O)c2cc3c(C(F)(F)F)nn(C)c3s2)c(C)n1 to have a higher LogP value.,CCn1cc([C@H](C)NC(=O)c2cc3c(C(F)(F)F)nn(C)c3s2)c(C)n1,3.6694200000000023
177627,Modify the molecule CC(C)CNC(=O)[C@@H](C)[S@](=O)c1cccc(F)c1 to increase its LogP value.,CC(C)CNC(=O)[C@@H](C)[S@](=O)c1cccc(F)c1,2.094
227607,Optimize the molecule Fc1ccc(NC(=S)N(Cc2ccccc2)Cc2ccncc2)cc1Cl to have a higher LogP value.,Fc1ccc(NC(=S)N(Cc2ccccc2)Cc2ccncc2)cc1Cl,5.273300000000003
186203,Please optimize the molecule COCCNC(=O)c1cccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])c1 to have a lower LogP value.,COCCNC(=O)c1cccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])c1,0.5576000000000003
217795,Please optimize the molecule O[C@@H](Cc1ccncc1)Cc1nc2ccccc2s1 to have a higher LogP value.,O[C@@H](Cc1ccncc1)Cc1nc2ccccc2s1,2.8374000000000015
24210,Modify the molecule C[C@]12CC[C@@]3(C)OCC(CO)(CO1)N23 to have a lower LogP value.,C[C@]12CC[C@@]3(C)OCC(CO)(CO1)N23,0.3061000000000001
155263,Modify the molecule COCCCNC(=O)CN1C(=O)[C@@H]2CCCCN2c2ccc(C(=O)N(C)C)cc21 to increase its LogP value.,COCCCNC(=O)CN1C(=O)[C@@H]2CCCCN2c2ccc(C(=O)N(C)C)cc21,1.2466000000000015
96770,Modify the molecule C[C@@]1(C(=O)[O-])CCCN1C(=O)NC[C@@]1(C)CCCO1 to increase its LogP value.,C[C@@]1(C(=O)[O-])CCCN1C(=O)NC[C@@]1(C)CCCO1,-0.13049999999999917
115797,Please modify the molecule Cc1cc(C[S@@](=O)CC(=O)Nc2cccc(Cl)c2Cl)on1 to increase its LogP value.,Cc1cc(C[S@@](=O)CC(=O)Nc2cccc(Cl)c2Cl)on1,3.177220000000001
342,Please modify the molecule CCc1nc2n(n1)CCC[C@H]2NC(=O)c1ccc(-n2cc(C)cn2)cc1 to increase its LogP value.,CCc1nc2n(n1)CCC[C@H]2NC(=O)c1ccc(-n2cc(C)cn2)cc1,2.599520000000001
248639,Modify the molecule C[C@@H]([NH2+]CCN(C)C1CCCCC1)c1ccc2[nH]c(=O)[nH]c2c1 to have a higher LogP value.,C[C@@H]([NH2+]CCN(C)C1CCCCC1)c1ccc2[nH]c(=O)[nH]c2c1,1.745099999999999
63423,Please modify the molecule Cc1nc(C[NH+]2CCC(Oc3ccnc(C(N)=O)c3)CC2)oc1C to decrease its LogP value.,Cc1nc(C[NH+]2CCC(Oc3ccnc(C(N)=O)c3)CC2)oc1C,0.41164000000000045
38273,Optimize the molecule Cc1nc2cc(NC(=O)CNC(=O)c3sc4ccccc4c3Cl)ccc2o1 to have a higher LogP value.,Cc1nc2cc(NC(=O)CNC(=O)c3sc4ccccc4c3Cl)ccc2o1,4.372820000000003
194805,Please modify the molecule COc1ccccc1CN(C(=O)Nc1ccc(SC)cc1)C1CC1 to decrease its LogP value.,COc1ccccc1CN(C(=O)Nc1ccc(SC)cc1)C1CC1,4.6136000000000035
28080,Modify the molecule O=C(N[C@H]1CC[NH+](CC2CC2)C1)c1ccc(OCC(F)F)nc1 to have a lower LogP value.,O=C(N[C@H]1CC[NH+](CC2CC2)C1)c1ccc(OCC(F)F)nc1,0.5225000000000002
10463,Modify the molecule COc1nc(C(=O)N(CCC(F)(F)F)C2CCCC2)cc2ccccc12 to increase its LogP value.,COc1nc(C(=O)N(CCC(F)(F)F)C2CCCC2)cc2ccccc12,4.580600000000004
224104,Optimize the molecule CCOC(=O)c1nnnn1Cc1cccc(O)c1 to have a higher LogP value.,CCOC(=O)c1nnnn1Cc1cccc(O)c1,0.6036999999999995
34351,Please optimize the molecule CCNc1ccc(C(=O)N2CC[NH+]3CCC[C@@H]3C2)cc1 to have a lower LogP value.,CCNc1ccc(C(=O)N2CC[NH+]3CCC[C@@H]3C2)cc1,0.6215000000000006
144883,Modify the molecule CNC(=O)c1ccc(Cl)cc1NC(=O)CCNC(=O)[C@@H]1C[C@H]1C to increase its LogP value.,CNC(=O)c1ccc(Cl)cc1NC(=O)CCNC(=O)[C@@H]1C[C@H]1C,1.8003999999999998
249084,Please optimize the molecule COc1ccccc1NC(=O)[C@@]1(c2ccccc2)CC1(Cl)Cl to have a higher LogP value.,COc1ccccc1NC(=O)[C@@]1(c2ccccc2)CC1(Cl)Cl,4.149300000000003
146770,Modify the molecule C[C@](O)(CNC(=O)/C=C/c1ccc2c(c1)OCCO2)c1ccc(F)cc1 to increase its LogP value.,C[C@](O)(CNC(=O)/C=C/c1ccc2c(c1)OCCO2)c1ccc(F)cc1,2.6340000000000012
176917,Optimize the molecule O=C1Nc2cc(S(=O)(=O)Nc3cccc4c3CCCC4)ccc2SC[C@H]1CC(=O)N1CCCC1 to have a lower LogP value.,O=C1Nc2cc(S(=O)(=O)Nc3cccc4c3CCCC4)ccc2SC[C@H]1CC(=O)N1CCCC1,4.039100000000003
183900,Optimize the molecule COc1ccccc1COC1CCN(S(=O)(=O)CC#N)CC1 to have a higher LogP value.,COc1ccccc1COC1CCN(S(=O)(=O)CC#N)CC1,1.5295800000000002
146586,Optimize the molecule O=C(NCCCc1cccc(F)c1)NOCc1ccccc1 to have a lower LogP value.,O=C(NCCCc1cccc(F)c1)NOCc1ccccc1,3.189300000000001
207684,Modify the molecule COCCN1[C@H](C)C[NH+](Cc2ccc([S@](C)=O)cc2)C[C@H]1C to have a higher LogP value.,COCCN1[C@H](C)C[NH+](Cc2ccc([S@](C)=O)cc2)C[C@H]1C,0.5479000000000023
21497,Please modify the molecule C[C@@H]([NH+](C)Cc1cnc(-c2ccccn2)s1)C1(C)CC1 to increase its LogP value.,C[C@@H]([NH+](C)Cc1cnc(-c2ccccn2)s1)C1(C)CC1,2.4084000000000003
171857,Please optimize the molecule CCC(C)(C)c1nnc(NC(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)s1 to have a lower LogP value.,CCC(C)(C)c1nnc(NC(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)s1,4.659200000000004
51084,Modify the molecule O=C(c1cccnc1OCC(F)F)N1CCO[C@@H](c2cccc(F)c2)C1 to increase its LogP value.,O=C(c1cccnc1OCC(F)F)N1CCO[C@@H](c2cccc(F)c2)C1,3.0783000000000014
107680,Modify the molecule CCN1C[C@@]2(C(=O)[O-])CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1=O to have a higher LogP value.,CCN1C[C@@]2(C(=O)[O-])CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1=O,0.17819999999999991
133968,Modify the molecule COC(=O)c1cccc(OC)c1OCc1cc(C)nc2ccccc12 to have a higher LogP value.,COC(=O)c1cccc(OC)c1OCc1cc(C)nc2ccccc12,3.9174200000000026
23053,Please optimize the molecule Cn1cccc1[C@@H](CNC(=O)C(N)=O)N1CCc2ccccc2C1 to have a lower LogP value.,Cn1cccc1[C@@H](CNC(=O)C(N)=O)N1CCc2ccccc2C1,0.7260000000000006
72558,Modify the molecule COc1ccc([C@H](C)NC(=O)c2cc(C)n(C3CC3)c2C)c(OC)c1 to decrease its LogP value.,COc1ccc([C@H](C)NC(=O)c2cc(C)n(C3CC3)c2C)c(OC)c1,3.9480400000000033
90013,Modify the molecule C[C@@H](CC(=O)N1CCOC[C@H]1C(N)=O)Cc1ccc(Cl)cc1 to increase its LogP value.,C[C@@H](CC(=O)N1CCOC[C@H]1C(N)=O)Cc1ccc(Cl)cc1,1.6214000000000004
126903,Optimize the molecule CC[C@@H]([NH3+])[C@H](SC1COC1)c1ccncc1 to have a lower LogP value.,CC[C@@H]([NH3+])[C@H](SC1COC1)c1ccncc1,1.2751999999999992
50379,Optimize the molecule COc1c2c(cc3c1[C@H](CC(=O)[C@]1(C)CCOC1=O)[N+](C)(C)CC3)OCO2 to have a higher LogP value.,COc1c2c(cc3c1[C@H](CC(=O)[C@]1(C)CCOC1=O)[N+](C)(C)CC3)OCO2,2.009899999999999
102265,Optimize the molecule CC[C@](C)([C@H](N)c1ccc(OC(C)C)cc1)[NH+]1CCCC1 to have a lower LogP value.,CC[C@](C)([C@H](N)c1ccc(OC(C)C)cc1)[NH+]1CCCC1,2.3209999999999997
24225,Please optimize the molecule C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1 to have a lower LogP value.,C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1,4.020100000000003
123529,Modify the molecule Cc1csc(Sc2ccc([N+](=O)[O-])cc2C(=O)OCc2cn3cc(Cl)ccc3n2)n1 to have a lower LogP value.,Cc1csc(Sc2ccc([N+](=O)[O-])cc2C(=O)OCc2cn3cc(Cl)ccc3n2)n1,5.169020000000003
155489,Modify the molecule CSc1ccc(C(=O)N2CCC[C@@H](C#N)C2)cc1 to increase its LogP value.,CSc1ccc(C(=O)N2CCC[C@@H](C#N)C2)cc1,2.7842800000000016
115473,Please optimize the molecule [NH3+]C1CC(NC(=O)[C@H]2CSc3ccccc32)C1 to have a higher LogP value.,[NH3+]C1CC(NC(=O)[C@H]2CSc3ccccc32)C1,0.7649999999999999
200487,Please modify the molecule C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)N(Cc3ccccc3)c3ccccc3)c2)C1 to decrease its LogP value.,C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)N(Cc3ccccc3)c3ccccc3)c2)C1,4.954200000000005
113109,Optimize the molecule C[C@@H]1CN(c2nc3ccccn3c2CC[NH3+])C[C@H]1C to have a higher LogP value.,C[C@@H]1CN(c2nc3ccccn3c2CC[NH3+])C[C@H]1C,1.2108999999999999
212277,Please optimize the molecule CN1CCC[C@](O)(C[NH2+]Cc2c[nH]nc2-c2ccc(Cl)cc2)C1=O to have a higher LogP value.,CN1CCC[C@](O)(C[NH2+]Cc2c[nH]nc2-c2ccc(Cl)cc2)C1=O,0.7768000000000003
145931,Please optimize the molecule O=C(/C=C(/c1ccc(Cl)cc1)C(F)(F)F)N(Cc1ccccc1O)C[C@@H]1CCCO1 to have a higher LogP value.,O=C(/C=C(/c1ccc(Cl)cc1)C(F)(F)F)N(Cc1ccccc1O)C[C@@H]1CCCO1,5.199100000000004
183479,Modify the molecule COC[C@@H]1CCCC[C@H](Cl)C1 to increase its LogP value.,COC[C@@H]1CCCC[C@H](Cl)C1,2.820500000000001
222957,Modify the molecule COc1ccccc1[C@H]1C[C@@H](C(F)F)n2ncc(C#N)c2N1 to have a lower LogP value.,COc1ccccc1[C@H]1C[C@@H](C(F)F)n2ncc(C#N)c2N1,3.126480000000001
26875,Modify the molecule CC[NH+]1CC[C@H](N(C)CC(=O)Nc2c(C)nn(C)c2C)[C@H](C)C1 to increase its LogP value.,CC[NH+]1CC[C@H](N(C)CC(=O)Nc2c(C)nn(C)c2C)[C@H](C)C1,0.2204400000000024
146566,Modify the molecule COc1cccc([C@H]2CN(Cc3cccc(O)c3)CCO2)c1 to have a lower LogP value.,COc1cccc([C@H]2CN(Cc3cccc(O)c3)CCO2)c1,2.9743000000000013
175483,Modify the molecule CC(C)[C@@H]1C[C@@](O)(c2cscc2Br)CCO1 to decrease its LogP value.,CC(C)[C@@H]1C[C@@](O)(c2cscc2Br)CCO1,3.5332000000000026
27951,Optimize the molecule CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1cc(-c2cccc([N+](=O)[O-])c2)n[nH]1 to have a higher LogP value.,CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1cc(-c2cccc([N+](=O)[O-])c2)n[nH]1,4.434400000000003
111245,Please optimize the molecule COC[C@H](C)NC(=O)Nc1ccccc1OC to have a lower LogP value.,COC[C@H](C)NC(=O)Nc1ccccc1OC,1.8516
244185,Please modify the molecule O=C(COc1ccccc1)Nc1ccc(OC[C@@H]2CCCO2)cc1 to increase its LogP value.,O=C(COc1ccccc1)Nc1ccc(OC[C@@H]2CCCO2)cc1,3.2619000000000016
137739,Please optimize the molecule COc1ccc(Br)cc1S(=O)(=O)NCCCn1ccc2ccccc21 to have a lower LogP value.,COc1ccc(Br)cc1S(=O)(=O)NCCCn1ccc2ccccc21,3.7810000000000024
150268,Please optimize the molecule CCc1cnc(CCNC(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)s1 to have a higher LogP value.,CCc1cnc(CCNC(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)s1,1.7577999999999998
83607,Please modify the molecule Cc1ccccc1N1C(=N)S/C(=C\c2ccccc2OCC(=O)Nc2ccc(F)cc2)C1=O to decrease its LogP value.,Cc1ccccc1N1C(=N)S/C(=C\c2ccccc2OCC(=O)Nc2ccc(F)cc2)C1=O,5.207290000000004
12628,Modify the molecule CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1 to decrease its LogP value.,CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1,3.559700000000002
5577,Please optimize the molecule Cc1noc2nc(C3CCN(C(=O)COC[C@H]4CCCO4)CC3)cc(C(F)(F)F)c12 to have a lower LogP value.,Cc1noc2nc(C3CCN(C(=O)COC[C@H]4CCCO4)CC3)cc(C(F)(F)F)c12,3.451620000000002
82886,Please optimize the molecule Cc1ccc(-c2csc(N3CCC[C@H](c4nncn4C(C)C)C3)n2)cc1 to have a lower LogP value.,Cc1ccc(-c2csc(N3CCC[C@H](c4nncn4C(C)C)C3)n2)cc1,4.674920000000004
235561,Please modify the molecule COc1ccc(NC(=O)N(C)CCc2noc(-c3ccc(F)cc3)n2)cc1 to decrease its LogP value.,COc1ccc(NC(=O)N(C)CCc2noc(-c3ccc(F)cc3)n2)cc1,3.590700000000002
246320,Please modify the molecule O=C(Nc1cccc(Cl)c1Cl)c1ccccc1N1CCCC1=O to decrease its LogP value.,O=C(Nc1cccc(Cl)c1Cl)c1ccccc1N1CCCC1=O,4.372500000000002
233198,Please optimize the molecule Cc1ccccc1OCCN(C)C(=O)[C@H]1CCCCN1S(C)(=O)=O to have a lower LogP value.,Cc1ccccc1OCCN(C)C(=O)[C@H]1CCCCN1S(C)(=O)=O,1.6463200000000002
192917,Modify the molecule Cc1cc(NC(=O)c2sc3ccccc3c2C)ccc1C(N)=O to have a higher LogP value.,Cc1cc(NC(=O)c2sc3ccccc3c2C)ccc1C(N)=O,3.869340000000001
12724,Optimize the molecule CCCN(C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1 to have a lower LogP value.,CCCN(C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1,1.1394000000000004
13242,Please modify the molecule CS[C@@H](C)c1cccc(NC(=O)CSCc2ccncc2)c1 to decrease its LogP value.,CS[C@@H](C)c1cccc(NC(=O)CSCc2ccncc2)c1,4.377500000000003
175167,Optimize the molecule CC(C)=CC[NH+]1CCC2(CC[C@H](CNC(=O)c3cc(C)n(C)n3)O2)CC1 to have a lower LogP value.,CC(C)=CC[NH+]1CCC2(CC[C@H](CNC(=O)c3cc(C)n(C)n3)O2)CC1,1.0210200000000014
217962,Optimize the molecule Cc1ccc(Cn2nc(C)c(C(=O)OCC(=O)N3CCC(C(N)=O)CC3)c2Cl)cc1 to have a higher LogP value.,Cc1ccc(Cn2nc(C)c(C(=O)OCC(=O)N3CCC(C(N)=O)CC3)c2Cl)cc1,2.08234
197084,Modify the molecule C[C@H](c1cc2ccccc2o1)N(C)Cc1nnsc1Cl to decrease its LogP value.,C[C@H](c1cc2ccccc2o1)N(C)Cc1nnsc1Cl,4.130700000000003
33110,Modify the molecule Cn1c(=O)oc2ccc(NC(=O)c3cc(F)ccc3O)cc21 to have a higher LogP value.,Cn1c(=O)oc2ccc(NC(=O)c3cc(F)ccc3O)cc21,2.2285000000000004
68627,Please modify the molecule COC(=O)c1cnc(NC(=O)C2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)s1 to decrease its LogP value.,COC(=O)c1cnc(NC(=O)C2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)s1,3.852000000000002
46226,Optimize the molecule O=C(CSc1nnc2ccc(-c3cccnc3)nn12)c1cccc([N+](=O)[O-])c1 to have a higher LogP value.,O=C(CSc1nnc2ccc(-c3cccnc3)nn12)c1cccc([N+](=O)[O-])c1,3.0695000000000014
170395,Modify the molecule CCc1ccccc1CNC(=O)N[C@H](C)[C@H](CO)SC to have a lower LogP value.,CCc1ccccc1CNC(=O)N[C@H](C)[C@H](CO)SC,2.1605999999999996
127247,Please optimize the molecule CCOc1ccc(C)cc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(CC)CCO2 to have a higher LogP value.,CCOc1ccc(C)cc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(CC)CCO2,3.0490200000000014
231722,Optimize the molecule CCc1cccc2c1NC(=O)[C@]21[C@@H]2C(=O)N(c3ccccc3F)C(=O)[C@@H]2[C@@H]2CCC[NH+]21 to have a lower LogP value.,CCc1cccc2c1NC(=O)[C@]21[C@@H]2C(=O)N(c3ccccc3F)C(=O)[C@@H]2[C@@H]2CCC[NH+]21,1.4022
245635,Modify the molecule CN1CCNC(=O)C12CC[NH+](Cc1cc(F)ccc1-n1cccn1)CC2 to have a higher LogP value.,CN1CCNC(=O)C12CC[NH+](Cc1cc(F)ccc1-n1cccn1)CC2,-0.009499999999998066
54130,Modify the molecule CCC(CC)C1=CC(=O)CC(C)(C)C1 to have a higher LogP value.,CCC(CC)C1=CC(=O)CC(C)(C)C1,3.738100000000003
141669,Modify the molecule N#Cc1cc(F)ccc1NC(=O)c1ccnc(OCC(F)F)c1 to decrease its LogP value.,N#Cc1cc(F)ccc1NC(=O)c1ccnc(OCC(F)F)c1,2.9885800000000007
98175,Optimize the molecule O=C(N[C@H]1CCN(C(=O)c2nn(-c3ccccc3)c(=O)c3ncccc23)C1)c1ccccc1 to have a lower LogP value.,O=C(N[C@H]1CCN(C(=O)c2nn(-c3ccccc3)c(=O)c3ncccc23)C1)c1ccccc1,2.4251999999999994
186900,Modify the molecule N#CCCN(Cc1ccco1)C(=O)c1cc(F)ccc1O to have a lower LogP value.,N#CCCN(Cc1ccco1)C(=O)c1cc(F)ccc1O,2.6803800000000018
229983,Modify the molecule NC(=O)c1ccc(COc2ccc(I)cc2)c(F)c1 to decrease its LogP value.,NC(=O)c1ccc(COc2ccc(I)cc2)c(F)c1,3.108200000000002
8946,Modify the molecule O=[N+]([O-])c1ccccc1N1CCN(Cc2nnc(-c3ccccc3Br)o2)CC1 to have a higher LogP value.,O=[N+]([O-])c1ccccc1N1CCN(Cc2nnc(-c3ccccc3Br)o2)CC1,3.7295000000000025
37486,Please optimize the molecule CCC1CCC(NS(=O)(=O)c2cc(C(=O)OC)n(C)c2)CC1 to have a lower LogP value.,CCC1CCC(NS(=O)(=O)c2cc(C(=O)OC)n(C)c2)CC1,2.0587999999999997
240361,Modify the molecule COC(=O)[C@@H](c1ccccc1)[NH+]1CCN(C/C=C/c2ccccc2)CC1 to have a lower LogP value.,COC(=O)[C@@H](c1ccccc1)[NH+]1CCN(C/C=C/c2ccccc2)CC1,1.8145999999999998
235319,Modify the molecule Cc1ccc([C@@H]2c3cccn3CCN2C(=S)Nc2ccccc2)cc1 to have a higher LogP value.,Cc1ccc([C@@H]2c3cccn3CCN2C(=S)Nc2ccccc2)cc1,4.598520000000003
219580,Modify the molecule Cc1cc(C(=O)NNC(=O)c2cc([N+](=O)[O-])ccc2N2CCC(C)CC2)c(C)o1 to increase its LogP value.,Cc1cc(C(=O)NNC(=O)c2cc([N+](=O)[O-])ccc2N2CCC(C)CC2)c(C)o1,3.1157400000000015
130121,Modify the molecule Cc1cc(NCc2ccc(CN3CCCC3=O)cc2)[nH+]c2ccccc12 to increase its LogP value.,Cc1cc(NCc2ccc(CN3CCCC3=O)cc2)[nH+]c2ccccc12,3.6968200000000024
38248,Please modify the molecule CCN[C@H]1CCC[NH+](C(C)C)C1 to decrease its LogP value.,CCN[C@H]1CCC[NH+](C(C)C)C1,0.051600000000000756
213527,Modify the molecule Cc1cccc(Cl)c1NC(=O)c1ccc(-n2cncn2)c(F)c1 to decrease its LogP value.,Cc1cccc(Cl)c1NC(=O)c1ccc(-n2cncn2)c(F)c1,3.6205200000000017
195139,Modify the molecule CC(C)N(C)C(=O)NCc1ccc(C(=O)N(C)C)cc1 to have a higher LogP value.,CC(C)N(C)C(=O)NCc1ccc(C(=O)N(C)C)cc1,1.9382000000000001
106428,Please modify the molecule CCC[C@@H](C)[C@H]([NH2+]CC)C(C)C to decrease its LogP value.,CCC[C@@H](C)[C@H]([NH2+]CC)C(C)C,2.0304999999999995
83645,Modify the molecule COc1cccc(-n2c(S)nnc2CSCc2ccc(F)cc2Cl)c1 to decrease its LogP value.,COc1cccc(-n2c(S)nnc2CSCc2ccc(F)cc2Cl)c1,4.790500000000002
160249,Modify the molecule CCN(CC)C(=O)OCC[NH2+]C to have a lower LogP value.,CCN(CC)C(=O)OCC[NH2+]C,-0.3419999999999983
38669,Modify the molecule CC(C)c1nn(C)c(Cl)c1CN1CCCN(c2ccccc2C#N)CC1 to have a higher LogP value.,CC(C)c1nn(C)c(Cl)c1CN1CCCN(c2ccccc2C#N)CC1,3.7808800000000033
43423,Modify the molecule C[C@H]([C@@H](C)S(C)(=O)=O)N(C)C(=O)C/C=C/c1ccc(F)cc1 to decrease its LogP value.,C[C@H]([C@@H](C)S(C)(=O)=O)N(C)C(=O)C/C=C/c1ccc(F)cc1,2.5090000000000003
149310,Modify the molecule COc1cc(NCc2ccc(Cl)s2)cc(OC)c1OC to have a higher LogP value.,COc1cc(NCc2ccc(Cl)s2)cc(OC)c1OC,4.039400000000003
59477,Please optimize the molecule C=CCSc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3 to have a lower LogP value.,C=CCSc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3,4.233000000000003
192372,Please optimize the molecule O=C(Cl)c1ccc2sccc2c1 to have a higher LogP value.,O=C(Cl)c1ccc2sccc2c1,3.2803000000000013
10005,Please modify the molecule COc1ccccc1OCCn1c(-c2ccccc2)noc1=O to increase its LogP value.,COc1ccccc1OCCn1c(-c2ccccc2)noc1=O,2.5909000000000004
22629,Modify the molecule CC[C@@H]1CCCCN1S(=O)(=O)c1ccc(N2C(=O)CCCC2=O)cc1 to increase its LogP value.,CC[C@@H]1CCCCN1S(=O)(=O)c1ccc(N2C(=O)CCCC2=O)cc1,2.683300000000001
91069,Please optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)c1c(F)cccc1F to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)c1c(F)cccc1F,2.876100000000001
135590,Modify the molecule O=C(NCc1ccc(F)cc1)c1cc(S(=O)(=O)N2CCCC2)ccc1Cl to decrease its LogP value.,O=C(NCc1ccc(F)cc1)c1cc(S(=O)(=O)N2CCCC2)ccc1Cl,3.1936000000000018
136657,Please modify the molecule COC(C)(C)c1noc([C@H]2CCCN(C(=O)c3cc(C)cc(C)c3)C2)n1 to increase its LogP value.,COC(C)(C)c1noc([C@H]2CCCN(C(=O)c3cc(C)cc(C)c3)C2)n1,3.587740000000003
127533,Please optimize the molecule Cc1ccc(C)c(C(=O)OCc2nc(-c3cccc(Cl)c3)no2)c1 to have a higher LogP value.,Cc1ccc(C)c(C(=O)OCc2nc(-c3cccc(Cl)c3)no2)c1,4.363840000000003
7354,Please optimize the molecule CC(=O)Nc1c(C)cc(NC(=O)c2cc(C)nc3c2c(=O)[nH]n3C)cc1C to have a lower LogP value.,CC(=O)Nc1c(C)cc(NC(=O)c2cc(C)nc3c2c(=O)[nH]n3C)cc1C,2.3975600000000004
8086,Modify the molecule COc1ccc(CCNC(=O)CN2C(=O)c3cccc4cccc(c34)C2=O)cc1OC to increase its LogP value.,COc1ccc(CCNC(=O)CN2C(=O)c3cccc4cccc(c34)C2=O)cc1OC,2.8119000000000005
213421,Optimize the molecule CNc1cccc(CN(C)c2ccccc2OC)[nH+]1 to have a higher LogP value.,CNc1cccc(CN(C)c2ccccc2OC)[nH+]1,2.1874
73152,Modify the molecule CN(C)C(=O)Nc1cccc(C(=O)N2CCSC3(CCCCC3)C2)c1 to decrease its LogP value.,CN(C)C(=O)Nc1cccc(C(=O)N2CCSC3(CCCCC3)C2)c1,3.6720000000000033
62929,Modify the molecule Cc1noc(C)c1CCCNC(=O)N1CCOC[C@H]1CC(C)C to increase its LogP value.,Cc1noc(C)c1CCCNC(=O)N1CCOC[C@H]1CC(C)C,2.6805400000000006
94961,Please optimize the molecule Cc1ccc(C)c(NC(=O)OC2CCCCC2)c1 to have a higher LogP value.,Cc1ccc(C)c(NC(=O)OC2CCCCC2)c1,4.184640000000003
15294,Optimize the molecule COCCc1nc(C)c([C@H](C)[NH2+][C@H]2[C@@H]3CCO[C@@H]3C2(C)C)s1 to have a higher LogP value.,COCCc1nc(C)c([C@H](C)[NH2+][C@H]2[C@@H]3CCO[C@@H]3C2(C)C)s1,2.07832
2704,Optimize the molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 to have a lower LogP value.,COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1,3.030100000000001
232572,Modify the molecule C[C@H](NC(=O)N1CCN(c2ccc(F)cn2)CC1)c1ccccc1Cl to increase its LogP value.,C[C@H](NC(=O)N1CCN(c2ccc(F)cn2)CC1)c1ccccc1Cl,3.4669000000000025
201650,Optimize the molecule CCOC(=O)[C@H](C)CSC1COC1 to have a lower LogP value.,CCOC(=O)[C@H](C)CSC1COC1,1.3176
92989,Please modify the molecule CC[C@@](C)(NC(=O)c1sc2cc(F)ccc2c1Cl)C(=O)[O-] to increase its LogP value.,CC[C@@](C)(NC(=O)c1sc2cc(F)ccc2c1Cl)C(=O)[O-],2.342200000000001
182481,Modify the molecule Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)NCc4ccccc4)c(C)nc32)cc1 to have a lower LogP value.,Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)NCc4ccccc4)c(C)nc32)cc1,4.903180000000004
3356,Modify the molecule CCc1ccc(C2=C[C@@H]3C(=O)N=N[C@H](SCC(=O)c4ccc5c(c4)OCO5)N3N2)cc1 to have a higher LogP value.,CCc1ccc(C2=C[C@@H]3C(=O)N=N[C@H](SCC(=O)c4ccc5c(c4)OCO5)N3N2)cc1,3.3995000000000015
179013,Please modify the molecule CC(C)c1nc(C[NH+]2CC[C@@H]3[C@@H](CCC(=O)N3CCC[NH3+])C2)co1 to increase its LogP value.,CC(C)c1nc(C[NH+]2CC[C@@H]3[C@@H](CCC(=O)N3CCC[NH3+])C2)co1,-0.1741999999999968
193093,Optimize the molecule CSc1ccc2c(c1)CCC[C@H]2[NH2+][C@H]1CCCn2nc(C)nc21 to have a higher LogP value.,CSc1ccc2c(c1)CCC[C@H]2[NH2+][C@H]1CCCn2nc(C)nc21,2.784320000000001
182533,Optimize the molecule CCC[C@H]([NH3+])CCC[C@H]1COc2ccccc21 to have a higher LogP value.,CCC[C@H]([NH3+])CCC[C@H]1COc2ccccc21,2.743500000000001
225359,Modify the molecule C[C@@H](CC(=O)[C@H](C#N)c1nc(N)nc(Nc2ccccc2)n1)c1ccccc1 to increase its LogP value.,C[C@@H](CC(=O)[C@H](C#N)c1nc(N)nc(Nc2ccccc2)n1)c1ccccc1,3.5674800000000015
169166,Modify the molecule COc1ccc([C@@H]2[NH+]=N/C(=N\C(=O)Cc3ccccc3)S2)cc1OC to have a higher LogP value.,COc1ccc([C@@H]2[NH+]=N/C(=N\C(=O)Cc3ccccc3)S2)cc1OC,2.1072999999999995
103945,Modify the molecule Cc1ncc(CO/N=C(/N)Cc2cccnc2)s1 to have a lower LogP value.,Cc1ncc(CO/N=C(/N)Cc2cccnc2)s1,1.8780199999999998
107850,Please optimize the molecule CCc1nnc(SCC(=O)NNC(=O)COC)n1N to have a higher LogP value.,CCc1nnc(SCC(=O)NNC(=O)COC)n1N,-1.5597999999999976
181466,Please modify the molecule c1ccc2c(c1)CC1(CC[NH2+]CC1)C2 to decrease its LogP value.,c1ccc2c(c1)CC1(CC[NH2+]CC1)C2,1.1287999999999998
109588,Modify the molecule CC1(C)C[C@](C)(c2ccccc2)c2ccccc2N1C(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O to decrease its LogP value.,CC1(C)C[C@](C)(c2ccccc2)c2ccccc2N1C(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O,4.683100000000004
2824,Modify the molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 to have a lower LogP value.,CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1,2.706900000000001
23638,Optimize the molecule NC(=O)C1CCC(CNC(=O)CCC(=O)c2ccc3c(c2)CCCC3)CC1 to have a higher LogP value.,NC(=O)C1CCC(CNC(=O)CCC(=O)c2ccc3c(c2)CCCC3)CC1,2.9361999999999995
213340,Please modify the molecule CCCN(Cc1ccccc1)C(=O)c1cc2ccccc2oc1=O to decrease its LogP value.,CCCN(Cc1ccccc1)C(=O)c1cc2ccccc2oc1=O,3.8454000000000033
55438,Optimize the molecule Cc1cccc([C@H](CNC(=O)c2ccc(-n3cnc4ccccc43)cc2)N2CCOCC2)c1 to have a higher LogP value.,Cc1cccc([C@H](CNC(=O)c2ccc(-n3cnc4ccccc43)cc2)N2CCOCC2)c1,4.137220000000003
38958,Modify the molecule CC(C)[C@@H](Sc1nnc(N)s1)C(=O)N[C@@H]1CCCC[C@H]1C to have a higher LogP value.,CC(C)[C@@H](Sc1nnc(N)s1)C(=O)N[C@@H]1CCCC[C@H]1C,2.9319000000000015
71622,Modify the molecule CCc1nnc(C[NH+]2CC[C@H](Nc3ccccc3)C2)o1 to have a higher LogP value.,CCc1nnc(C[NH+]2CC[C@H](Nc3ccccc3)C2)o1,0.9013
89896,Modify the molecule C/[NH+]=C(/NCC1([NH+](C)C)CCOCC1)N1CC[C@@H]([NH+]2CCCC2)C1 to increase its LogP value.,C/[NH+]=C(/NCC1([NH+](C)C)CCOCC1)N1CC[C@@H]([NH+]2CCCC2)C1,-3.9108999999999963
227692,Please optimize the molecule Cn1cc(Br)cc1C(=O)Nc1cccc(N2CCCC2=O)c1 to have a higher LogP value.,Cn1cc(Br)cc1C(=O)Nc1cccc(N2CCCC2=O)c1,3.1667000000000014
95108,Please optimize the molecule COc1cc(C(=O)Nc2ccc3c(c2)NC(=O)[C@@H](C)O3)cc2c1OCCO2 to have a lower LogP value.,COc1cc(C(=O)Nc2ccc3c(c2)NC(=O)[C@@H](C)O3)cc2c1OCCO2,2.4381000000000004
10479,Optimize the molecule O=C(Nc1ccc2c(c1)OCCO2)[C@H]1CC(=O)N(CCC2=c3cc(Cl)ccc3=[NH+]C2)C1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)OCCO2)[C@H]1CC(=O)N(CCC2=c3cc(Cl)ccc3=[NH+]C2)C1,-0.1469999999999989
177264,Please optimize the molecule C[C@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)OC1CCCCC1)C2=O to have a higher LogP value.,C[C@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)OC1CCCCC1)C2=O,2.999100000000002
112269,Optimize the molecule CCOCc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H](O)C1 to have a lower LogP value.,CCOCc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H](O)C1,1.8289
22527,Optimize the molecule CCOc1cc2c(cc1OCC)[C@@H](c1ccc(OC)c3ccccc13)[NH2+]CC2 to have a higher LogP value.,CCOc1cc2c(cc1OCC)[C@@H](c1ccc(OC)c3ccccc13)[NH2+]CC2,3.854700000000001
122386,Please modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N2CCC(Cc3ccccc3)CC2)cc1 to decrease its LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N2CCC(Cc3ccccc3)CC2)cc1,5.189040000000005
25867,Please optimize the molecule COc1ccc(CC(=O)N/N=C\c2ccc(N(C)C)cc2)cc1OC to have a higher LogP value.,COc1ccc(CC(=O)N/N=C\c2ccc(N(C)C)cc2)cc1OC,2.4626
170801,Modify the molecule COC(=O)N1CC[C@@H]([NH2+][C@H](C)c2cc(C)sc2C)C1 to have a lower LogP value.,COC(=O)N1CC[C@@H]([NH2+][C@H](C)c2cc(C)sc2C)C1,1.8300400000000003
103351,Please optimize the molecule C[C@H]([NH2+]C1CCN([C@H](C)c2ccncc2)CC1)C1CCCCC1 to have a higher LogP value.,C[C@H]([NH2+]C1CCN([C@H](C)c2ccncc2)CC1)C1CCCCC1,3.1392000000000015
76575,Modify the molecule CN(Cc1ccccc1Br)S(=O)(=O)c1ccc(Br)cc1 to have a lower LogP value.,CN(Cc1ccccc1Br)S(=O)(=O)c1ccc(Br)cc1,4.032300000000003
177399,Modify the molecule Cc1ccc(/C=C2\SC(=S)N(CCN3CCOCC3)C2=O)c(C)c1 to have a higher LogP value.,Cc1ccc(/C=C2\SC(=S)N(CCN3CCOCC3)C2=O)c(C)c1,2.8368400000000005
216456,Modify the molecule CCOc1ccc([C@H](C)NC(=O)Nc2ccc3c(c2)OCCCO3)cc1 to have a lower LogP value.,CCOc1ccc([C@H](C)NC(=O)Nc2ccc3c(c2)OCCCO3)cc1,4.129300000000002
234056,Please modify the molecule CCCOc1ccc(C(=O)Nc2ccccc2C(=O)NCC)cc1 to increase its LogP value.,CCCOc1ccc(C(=O)Nc2ccccc2C(=O)NCC)cc1,3.477400000000002
67878,Please optimize the molecule COc1ccccc1-c1nnc(SCC(=O)Nc2ccc3c(c2)OCCO3)o1 to have a lower LogP value.,COc1ccccc1-c1nnc(SCC(=O)Nc2ccc3c(c2)OCCO3)o1,3.247200000000001
241330,Please modify the molecule CC(C)CNc1cnn(-c2ncccn2)c1 to increase its LogP value.,CC(C)CNc1cnn(-c2ncccn2)c1,1.7301999999999997
87941,Please modify the molecule C[C@H]1CCCC[C@H]1OCC(=O)Nc1ccc2c(c1)CCCC(=O)N2 to decrease its LogP value.,C[C@H]1CCCC[C@H]1OCC(=O)Nc1ccc2c(c1)CCCC(=O)N2,3.4952000000000023
18414,Modify the molecule Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)cc1S(=O)(=O)N1CCCCC1 to decrease its LogP value.,Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)cc1S(=O)(=O)N1CCCCC1,3.729720000000003
117688,Please modify the molecule CCOC(=O)C1=C(CN2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CCOC(=O)C1=C(CN2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@@H]1c1ccc(Cl)cc1,3.4890000000000017
52487,Modify the molecule Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2 to increase its LogP value.,Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2,-0.651299999999998
209004,Optimize the molecule CS[C@@H]1CCC[C@H](NC(=O)c2cc(C#N)cs2)C1 to have a higher LogP value.,CS[C@@H]1CCC[C@H](NC(=O)c2cc(C#N)cs2)C1,3.0237800000000012
3542,Please modify the molecule CCC(CC)[C@@H](C(=O)OC)C(=O)C(C)C to increase its LogP value.,CCC(CC)[C@@H](C(=O)OC)C(=O)C(C)C,2.4369000000000005
44241,Please modify the molecule C#CCN(CC1CC1)C(=O)c1cccc(OCC(F)F)n1 to decrease its LogP value.,C#CCN(CC1CC1)C(=O)c1cccc(OCC(F)F)n1,2.2109000000000005
165755,Optimize the molecule COc1ccc(-c2cc(CN(C)S(=O)(=O)c3ccc(Cl)cc3C(F)(F)F)on2)cc1 to have a higher LogP value.,COc1ccc(-c2cc(CN(C)S(=O)(=O)c3ccc(Cl)cc3C(F)(F)F)on2)cc1,4.843100000000003
178168,Optimize the molecule CN[C@@H]1C(=O)Nc2cc(Oc3ccccc3Cl)c(Cl)cc21 to have a higher LogP value.,CN[C@@H]1C(=O)Nc2cc(Oc3ccccc3Cl)c(Cl)cc21,3.998300000000002
127092,Optimize the molecule CCN[C@@]1(C(=O)OCC)CCC[C@H](N2CCO[C@H](C)C2)C1 to have a higher LogP value.,CCN[C@@]1(C(=O)OCC)CCC[C@H](N2CCO[C@H](C)C2)C1,1.5610999999999997
220512,Please optimize the molecule CCN(CC)c1ncnc2sc(C)cc12 to have a lower LogP value.,CCN(CC)c1ncnc2sc(C)cc12,2.8459200000000013
18379,Modify the molecule Cc1ncc([C@@H](C)N[C@@H]2CCCN(c3cccnn3)C2)s1 to decrease its LogP value.,Cc1ncc([C@@H](C)N[C@@H]2CCCN(c3cccnn3)C2)s1,2.5611200000000007
106013,Modify the molecule NC(=O)c1cc2cc(F)ccc2nc1C1CCN(C(=O)CN[C@H]2C=CS(=O)(=O)C2)CC1 to have a lower LogP value.,NC(=O)c1cc2cc(F)ccc2nc1C1CCN(C(=O)CN[C@H]2C=CS(=O)(=O)C2)CC1,1.0791
37337,Please modify the molecule CC(=O)NC1(C#N)CCCC1 to decrease its LogP value.,CC(=O)NC1(C#N)CCCC1,0.95888
223083,Modify the molecule COc1ccc(C[NH+]2CCN(c3cc(Cl)nc(N)n3)CC2)cc1 to increase its LogP value.,COc1ccc(C[NH+]2CCN(c3cc(Cl)nc(N)n3)CC2)cc1,0.6259000000000005
239509,Please modify the molecule COc1ccc(C)cc1[C@@](C)(O)C1(C)CC1 to decrease its LogP value.,COc1ccc(C)cc1[C@@](C)(O)C1(C)CC1,3.0112200000000016
221769,Modify the molecule Cc1ccc(C(=O)NCCc2ccc(F)cc2)s1 to have a lower LogP value.,Cc1ccc(C(=O)NCCc2ccc(F)cc2)s1,3.168120000000002
45248,Modify the molecule Cc1ccccc1[C@@H](CC(=O)NCCC(=O)N1CCCC1)NC(N)=O to have a higher LogP value.,Cc1ccccc1[C@@H](CC(=O)NCCC(=O)N1CCCC1)NC(N)=O,1.2232200000000004
227242,Please optimize the molecule CSCC[C@@H](C(=O)Nc1nccs1)N1C(=O)c2ccccc2C1=O to have a higher LogP value.,CSCC[C@@H](C(=O)Nc1nccs1)N1C(=O)c2ccccc2C1=O,2.4995000000000003
244668,Optimize the molecule CCc1ccc(-n2c(CN3CCN(S(=O)(=O)c4ccccc4)CC3)[nH+]c3cccnc32)cc1 to have a higher LogP value.,CCc1ccc(-n2c(CN3CCN(S(=O)(=O)c4ccccc4)CC3)[nH+]c3cccnc32)cc1,2.908500000000001
152761,Please modify the molecule N#Cc1ccc(OCCNC(=O)NC[C@@H](O)c2ccco2)cc1 to increase its LogP value.,N#Cc1ccc(OCCNC(=O)NC[C@@H](O)c2ccco2)cc1,1.5628799999999998
144801,Please modify the molecule [NH3+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1 to increase its LogP value.,[NH3+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1,-1.8769999999999958
21704,Please optimize the molecule COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1 to have a higher LogP value.,COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1,2.5814000000000004
89957,Modify the molecule COc1ccc(Cl)c(NC(=O)NCc2cc[nH+]c(N(C)C)c2)c1 to increase its LogP value.,COc1ccc(Cl)c(NC(=O)NCc2cc[nH+]c(N(C)C)c2)c1,2.5504000000000007
33826,Please modify the molecule O=C1C[C@H](Nc2ccc(Br)c([N+](=O)[O-])c2)CCCN1 to increase its LogP value.,O=C1C[C@H](Nc2ccc(Br)c([N+](=O)[O-])c2)CCCN1,2.4379
39228,Please optimize the molecule c1ccc(N2CCC([NH2+]Cc3ccccc3OC3CCC3)CC2)[nH+]c1 to have a higher LogP value.,c1ccc(N2CCC([NH2+]Cc3ccccc3OC3CCC3)CC2)[nH+]c1,2.1643999999999997
6691,Please optimize the molecule Cc1nn(C)cc1-c1cc(C(F)F)c2c(C(C)C)nn(-c3ccc(F)cc3)c2n1 to have a higher LogP value.,Cc1nn(C)cc1-c1cc(C(F)F)c2c(C(C)C)nn(-c3ccc(F)cc3)c2n1,5.329520000000004
196853,Optimize the molecule Nc1cccc2oc(Nc3cc(Cl)ccc3F)nc12 to have a higher LogP value.,Nc1cccc2oc(Nc3cc(Cl)ccc3F)nc12,3.9461000000000013
97443,Modify the molecule O=C(NCCO)c1ccccc1O to have a lower LogP value.,O=C(NCCO)c1ccccc1O,0.11430000000000001
120284,Modify the molecule CC(=O)N1CCN(C(=O)C(=O)Nc2c(C)nn(-c3ccccc3)c2C)CC1 to have a lower LogP value.,CC(=O)N1CCN(C(=O)C(=O)Nc2c(C)nn(-c3ccccc3)c2C)CC1,1.1183399999999994
50719,Modify the molecule CC[C@H](O)CCNC(=O)Nc1ccc(C(C)=O)c(C)c1 to have a lower LogP value.,CC[C@H](O)CCNC(=O)Nc1ccc(C(C)=O)c(C)c1,2.4801200000000003
89135,Please modify the molecule O=c1[nH]c([O-])nnc1Nn1cccc1 to decrease its LogP value.,O=c1[nH]c([O-])nnc1Nn1cccc1,-1.0848
653,Modify the molecule COc1ccccc1N1CC[NH+]([C@@H](C)C(=O)Nc2ccc(F)cc2)CC1 to decrease its LogP value.,COc1ccccc1N1CC[NH+]([C@@H](C)C(=O)Nc2ccc(F)cc2)CC1,1.5663999999999993
113219,Please modify the molecule Cc1cccc(COc2cccc(C(=O)Nc3ncccc3O)c2)c1 to decrease its LogP value.,Cc1cccc(COc2cccc(C(=O)Nc3ncccc3O)c2)c1,3.9269200000000017
63569,Please optimize the molecule CC[NH+](CC)CCCN1C(=O)c2oc3ccc(Cl)cc3c(=O)c2[C@H]1c1ccc(O)cc1 to have a higher LogP value.,CC[NH+](CC)CCCN1C(=O)c2oc3ccc(Cl)cc3c(=O)c2[C@H]1c1ccc(O)cc1,3.0120000000000013
162613,Modify the molecule N#C/C(=C\c1ccc2c(c1)OCO2)C(=O)Nc1ccc(-c2nnc3n2CCCCC3)cc1 to decrease its LogP value.,N#C/C(=C\c1ccc2c(c1)OCO2)C(=O)Nc1ccc(-c2nnc3n2CCCCC3)cc1,3.9458800000000025
110977,Please modify the molecule CCCCOC(=O)C1=C(C)Nc2nnnn2[C@H]1c1ccc(O)c(OC)c1 to increase its LogP value.,CCCCOC(=O)C1=C(C)Nc2nnnn2[C@H]1c1ccc(O)c(OC)c1,2.0194999999999994
167790,Optimize the molecule C[C@H](NC(=O)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1)c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,C[C@H](NC(=O)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1)c1ccc(Cl)c(Cl)c1,4.0427000000000035
139670,Please modify the molecule C[C@H](Sc1nc(-c2ccc(Cl)cc2)n[nH]1)C(=O)NCc1ccco1 to decrease its LogP value.,C[C@H](Sc1nc(-c2ccc(Cl)cc2)n[nH]1)C(=O)NCc1ccco1,3.5151000000000012
39137,Please modify the molecule CC(=O)N(c1nc(CSc2ncn[nH]2)cs1)c1c(C)cc(C)cc1C to decrease its LogP value.,CC(=O)N(c1nc(CSc2ncn[nH]2)cs1)c1c(C)cc(C)cc1C,4.163360000000003
148233,Optimize the molecule CN[C@@H](c1c[nH+]ccc1N)C1([NH+](C)C)CCCCCC1 to have a higher LogP value.,CN[C@@H](c1c[nH+]ccc1N)C1([NH+](C)C)CCCCCC1,0.5809000000000002
117975,Modify the molecule COC(=O)c1ccc(COCC[C@@H]2CCCC[NH2+]2)cc1 to have a lower LogP value.,COC(=O)c1ccc(COCC[C@@H]2CCCC[NH2+]2)cc1,1.4957999999999998
213668,Modify the molecule Cc1cc2n(n1)CCC(=O)N2[C@@H](C)C(=O)NCc1ccccn1 to have a higher LogP value.,Cc1cc2n(n1)CCC(=O)N2[C@@H](C)C(=O)NCc1ccccn1,1.028119999999999
96842,Please modify the molecule O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2cccs2)on1 to increase its LogP value.,O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2cccs2)on1,4.349300000000004
240595,Modify the molecule O=C1c2cnc3[nH]nc(-c4ccccc4)c3c2C(=O)N1Cc1ccccc1 to have a higher LogP value.,O=C1c2cnc3[nH]nc(-c4ccccc4)c3c2C(=O)N1Cc1ccccc1,3.421100000000002
144584,Modify the molecule COCCN(C(=O)NCCC1CCCC1)[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,COCCN(C(=O)NCCC1CCCC1)[C@@H]1CCS(=O)(=O)C1,1.4118
19376,Modify the molecule CC(=O)c1ccc(C(=O)Nc2ccc3c(c2)Cc2ccccc2-3)s1 to decrease its LogP value.,CC(=O)c1ccc(C(=O)Nc2ccc3c(c2)Cc2ccccc2-3)s1,4.774200000000002
96220,Please modify the molecule O=C(Cc1cc(Cl)c2c(c1)OCCCO2)OCc1cn2cc(Cl)ccc2n1 to decrease its LogP value.,O=C(Cc1cc(Cl)c2c(c1)OCCCO2)OCc1cn2cc(Cl)ccc2n1,4.088300000000003
198921,Modify the molecule CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1 to have a lower LogP value.,CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1,4.622600000000003
91495,Please modify the molecule O=C(c1cnoc1-c1ccccc1)N1CCOC[C@H](O)C1 to decrease its LogP value.,O=C(c1cnoc1-c1ccccc1)N1CCOC[C@H](O)C1,1.1748999999999998
101664,Please optimize the molecule CCn1ccnc(Nc2cc(OC)c(OC)cc2C)c1=O to have a higher LogP value.,CCn1ccnc(Nc2cc(OC)c(OC)cc2C)c1=O,2.33242
131162,Optimize the molecule Cc1ccc([C@@H](C)NCc2nc(C3CC3)cs2)cc1C to have a lower LogP value.,Cc1ccc([C@@H](C)NCc2nc(C3CC3)cs2)cc1C,4.488140000000004
185851,Modify the molecule CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2F)sc2c1CCCC2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2F)sc2c1CCCC2,4.488380000000004
31980,Please optimize the molecule CC[C@@H](C#N)S(=O)(=O)NCC1C(C)(C)C1(C)C to have a lower LogP value.,CC[C@@H](C#N)S(=O)(=O)NCC1C(C)(C)C1(C)C,1.89018
216251,Please modify the molecule CC[C@@H]1CN(C)c2ccccc2CN1C(=O)Nc1ccc(OC)c(OC)c1 to increase its LogP value.,CC[C@@H]1CN(C)c2ccccc2CN1C(=O)Nc1ccc(OC)c(OC)c1,3.966300000000003
96651,Optimize the molecule CCC[NH+](Cc1ccccc1)Cc1cc(Cl)ccc1N to have a lower LogP value.,CCC[NH+](Cc1ccccc1)Cc1cc(Cl)ccc1N,2.9173
91366,Modify the molecule Cc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C)o2)o1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C)o2)o1,3.994040000000002
62425,Please optimize the molecule Cc1ccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)cc1C to have a lower LogP value.,Cc1ccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)cc1C,4.107740000000002
149555,Please optimize the molecule O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1 to have a lower LogP value.,O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1,2.5623000000000005
164337,Please modify the molecule O=C(NC[C@H]1C[C@@H](O)C[NH+]1Cc1ccccc1)Nc1c(F)cccc1F to increase its LogP value.,O=C(NC[C@H]1C[C@@H](O)C[NH+]1Cc1ccccc1)Nc1c(F)cccc1F,1.3046000000000002
235654,Modify the molecule c1cc2c(s1)C1(CC[NH2+]CC1)OCC2 to have a lower LogP value.,c1cc2c(s1)C1(CC[NH2+]CC1)OCC2,0.8733000000000001
2402,Optimize the molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 to have a lower LogP value.,CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1,4.802800000000005
23,Optimize the molecule O=c1n(CCO)c2ccccc2n1CCO to have a higher LogP value.,O=c1n(CCO)c2ccccc2n1CCO,-0.2124000000000003
24755,Modify the molecule CCc1nn(C)cc1CNC(=O)[C@H]1CCCCN1C(=O)c1cccnc1 to decrease its LogP value.,CCc1nn(C)cc1CNC(=O)[C@H]1CCCCN1C(=O)c1cccnc1,1.6885999999999992
163726,Please optimize the molecule Cc1ccc(C(C)C)cc1O[C@@H](C)C(=O)N1CCCN(S(C)(=O)=O)CC1 to have a lower LogP value.,Cc1ccc(C(C)C)cc1O[C@@H](C)C(=O)N1CCCN(S(C)(=O)=O)CC1,2.37962
50301,Modify the molecule C[C@@]1(c2ccc3c(c2)OCCCO3)NC(=O)N(CC(=O)NC2CCCC2)C1=O to have a higher LogP value.,C[C@@]1(c2ccc3c(c2)OCCCO3)NC(=O)N(CC(=O)NC2CCCC2)C1=O,1.673699999999999
208289,Modify the molecule CS[C@@H]1CC[C@H](NC(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)C1 to have a lower LogP value.,CS[C@@H]1CC[C@H](NC(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)C1,3.0958000000000014
80068,Optimize the molecule CO[C@H](c1ccccc1)N1C(=O)C(C(=O)OC(C)(C)C)=C[C@@H]1C to have a higher LogP value.,CO[C@H](c1ccccc1)N1C(=O)C(C(=O)OC(C)(C)C)=C[C@@H]1C,2.830400000000001
7083,Optimize the molecule O=C(Nc1ccc(N2CCCC2)c(Cl)c1)C(=O)N1C[C@@H]2CC=CC[C@H]2C1 to have a higher LogP value.,O=C(Nc1ccc(N2CCCC2)c(Cl)c1)C(=O)N1C[C@@H]2CC=CC[C@H]2C1,3.303300000000002
71010,Optimize the molecule CC(C)c1cccc(C(C)C)c1NC(=O)C(=O)N1CCC2(C1)OCCO2 to have a higher LogP value.,CC(C)c1cccc(C(C)C)c1NC(=O)C(=O)N1CCC2(C1)OCCO2,2.8473000000000006
216669,Please optimize the molecule N#Cc1ccc(C[NH+]2CCCC[C@H]2Cn2cncn2)c(F)c1 to have a higher LogP value.,N#Cc1ccc(C[NH+]2CCCC[C@H]2Cn2cncn2)c(F)c1,0.9264799999999991
212913,Optimize the molecule CCCCCC(C)(C)CNC(=O)c1cccc2[nH]ccc12 to have a lower LogP value.,CCCCCC(C)(C)CNC(=O)c1cccc2[nH]ccc12,4.5042000000000035
99824,Please optimize the molecule CC1=N[C@H](C(=O)N2CCC(CC(=O)NCCC(C)C)CC2)C(C)=C1C to have a lower LogP value.,CC1=N[C@H](C(=O)N2CCC(CC(=O)NCCC(C)C)CC2)C(C)=C1C,2.956900000000001
204899,Modify the molecule O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(Br)cc1Br)N1CCOCC1 to have a lower LogP value.,O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(Br)cc1Br)N1CCOCC1,2.2234999999999996
68630,Optimize the molecule NC(=O)N1CCC([NH+]2CCC[C@@H](Oc3ccc(Cl)c(Cl)c3)C2)CC1 to have a higher LogP value.,NC(=O)N1CCC([NH+]2CCC[C@@H](Oc3ccc(Cl)c(Cl)c3)C2)CC1,1.9626
141302,Modify the molecule Cc1cccc(C)c1NC(=O)COC(=O)C[C@@H]1Sc2ccccc2NC1=O to decrease its LogP value.,Cc1cccc(C)c1NC(=O)COC(=O)C[C@@H]1Sc2ccccc2NC1=O,3.288240000000002
12864,Modify the molecule CCCOc1ccccc1C[C@H]1C(=O)Nc2ccc(C)cc21 to decrease its LogP value.,CCCOc1ccccc1C[C@H]1C(=O)Nc2ccc(C)cc21,4.0622200000000035
137028,Modify the molecule CCc1ccc(C(=O)N2CCc3sccc3[C@H]2C)o1 to increase its LogP value.,CCc1ccc(C(=O)N2CCc3sccc3[C@H]2C)o1,3.663000000000003
228602,Optimize the molecule CCN(C(=O)c1ccc(N2CCCOC2=O)cc1)c1cccc(C)c1 to have a higher LogP value.,CCN(C(=O)c1ccc(N2CCCOC2=O)cc1)c1cccc(C)c1,4.008420000000004
78763,Modify the molecule COCCCCN1CC[C@H]([NH3+])[C@@H](C)[C@@H]1C to decrease its LogP value.,COCCCCN1CC[C@H]([NH3+])[C@@H](C)[C@@H]1C,0.7538000000000015
165456,Modify the molecule Cc1noc(CCNC(=O)N[C@H](CO)c2ccc(Cl)cc2)n1 to have a higher LogP value.,Cc1noc(CCNC(=O)N[C@H](CO)c2ccc(Cl)cc2)n1,1.6067199999999997
197510,Please optimize the molecule C[C@@H]1CCN(C(=O)CCNc2ccccc2[N+](=O)[O-])C[C@@H]1O to have a lower LogP value.,C[C@@H]1CCN(C(=O)CCNc2ccccc2[N+](=O)[O-])C[C@@H]1O,1.6260999999999999
114744,Optimize the molecule COC(=O)CC[NH+]1CCCC1 to have a lower LogP value.,COC(=O)CC[NH+]1CCCC1,-0.7717999999999992
229849,Optimize the molecule OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](Cl)[C@@H]1O to have a lower LogP value.,OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](Cl)[C@@H]1O,-1.9749000000000005
55515,Modify the molecule COc1cc(C)c(C(=O)N(C)c2ccc(Cl)cn2)cc1OC to have a higher LogP value.,COc1cc(C)c(C(=O)N(C)c2ccc(Cl)cn2)cc1OC,3.337220000000002
248159,Modify the molecule Cc1ccc(N2C[C@H](C(=O)N3CCC(Oc4nc5c(Cl)cccc5s4)CC3)CC2=O)cc1C to have a lower LogP value.,Cc1ccc(N2C[C@H](C(=O)N3CCC(Oc4nc5c(Cl)cccc5s4)CC3)CC2=O)cc1C,4.9894400000000045
2688,Modify the molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 to decrease its LogP value.,CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1,4.026200000000003
91634,Please modify the molecule CSCc1ccc(C(=O)NNC(=O)CSc2ccc(C)cc2)cc1 to decrease its LogP value.,CSCc1ccc(C(=O)NNC(=O)CSc2ccc(C)cc2)cc1,3.4113200000000026
206599,Modify the molecule [NH3+]C[C@H](c1c[nH]c2ccccc12)C(F)(F)F to decrease its LogP value.,[NH3+]C[C@H](c1c[nH]c2ccccc12)C(F)(F)F,2.0557
204155,Please modify the molecule C[C@@H]([NH2+]Cc1cccnc1OCC(F)F)c1occc1Br to increase its LogP value.,C[C@@H]([NH2+]Cc1cccnc1OCC(F)F)c1occc1Br,2.9056000000000015
161062,Modify the molecule Cn1cnc(CNC(=O)c2ccccc2NC(=O)OC(C)(C)C)n1 to increase its LogP value.,Cn1cnc(CNC(=O)c2ccccc2NC(=O)OC(C)(C)C)n1,2.0921
147366,Modify the molecule O=C1C[C@@H]([C@H]2CCCO2)C(=O)N1Cc1ccccc1 to have a higher LogP value.,O=C1C[C@@H]([C@H]2CCCO2)C(=O)N1Cc1ccccc1,1.7407
210106,Modify the molecule COc1ccccc1[C@H](NC(=O)c1cc(C)ccc1F)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@H](NC(=O)c1cc(C)ccc1F)c1ccccn1,4.057120000000002
208859,Modify the molecule CSc1ccc2cc(CN(C[C@@H]3CCCO3)C(=O)c3ccc(C)s3)c(N3CCCC3)nc2c1 to have a higher LogP value.,CSc1ccc2cc(CN(C[C@@H]3CCCO3)C(=O)c3ccc(C)s3)c(N3CCCC3)nc2c1,5.748220000000006
50311,Please modify the molecule CC[C@@H](NC(=O)[C@H](c1ccccc1)N(C)CC)C(=O)N1CCOCC1 to decrease its LogP value.,CC[C@@H](NC(=O)[C@H](c1ccccc1)N(C)CC)C(=O)N1CCOCC1,1.433
91500,Please modify the molecule O=C1S/C(=C/c2ccc3c(c2)OCO3)C(=O)N1CN1CCCC1 to increase its LogP value.,O=C1S/C(=C/c2ccc3c(c2)OCO3)C(=O)N1CN1CCCC1,2.5049
105043,Modify the molecule [NH3+][C@@H]1CC[C@@H](Nc2cc(C(F)(F)F)ccc2F)C1 to increase its LogP value.,[NH3+][C@@H]1CC[C@@H](Nc2cc(C(F)(F)F)ccc2F)C1,2.4194000000000004
120752,Optimize the molecule C[C@H]1CCC[NH+](Cc2ccc(CNC(=O)Cc3ccon3)cc2)C1 to have a higher LogP value.,C[C@H]1CCC[NH+](Cc2ccc(CNC(=O)Cc3ccon3)cc2)C1,1.3482999999999996
224535,Optimize the molecule COc1ccccc1[C@@H](NC(=O)c1ccc2c(c1)CCC2)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@@H](NC(=O)c1ccc2c(c1)CCC2)c1ccccn1,4.098300000000003
218283,Modify the molecule CC/[NH+]=C(/NCc1cc(CC)no1)N1CCc2ccccc21 to have a lower LogP value.,CC/[NH+]=C(/NCc1cc(CC)no1)N1CCc2ccccc21,0.8457999999999997
79471,Modify the molecule N#Cc1c(Cl)nsc1NCc1ccc(C[NH+]2CCCCC2)cc1 to have a higher LogP value.,N#Cc1c(Cl)nsc1NCc1ccc(C[NH+]2CCCCC2)cc1,2.8490800000000007
27345,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CN(C)S(=O)(=O)c1ccc2[nH]c3c(c2c1)CCCC3 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)CN(C)S(=O)(=O)c1ccc2[nH]c3c(c2c1)CCCC3,4.267720000000002
45780,Modify the molecule C[C@@H](O)[C@@H](NC(=O)CSc1ccncc1)C(=O)[O-] to have a lower LogP value.,C[C@@H](O)[C@@H](NC(=O)CSc1ccncc1)C(=O)[O-],-1.2108000000000003
44407,Modify the molecule CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1 to have a higher LogP value.,CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1,2.2149
198727,Modify the molecule COC(=O)C1CCN(c2ncnc(NCc3ccc(OC)cc3)c2N)CC1 to have a higher LogP value.,COC(=O)C1CCN(c2ncnc(NCc3ccc(OC)cc3)c2N)CC1,2.0688999999999993
139646,Please optimize the molecule NS(=O)(=O)CCNC(=O)c1cc2c(s1)CCCC2 to have a lower LogP value.,NS(=O)(=O)CCNC(=O)c1cc2c(s1)CCCC2,0.6452000000000002
98059,Modify the molecule CCOCc1ccccc1Cn1c(=O)[nH]c2ccccc2c1=O to have a higher LogP value.,CCOCc1ccccc1Cn1c(=O)[nH]c2ccccc2c1=O,2.2746000000000004
48764,Modify the molecule O=C(COc1ccccc1Cl)NCCCN1CCOCC1 to decrease its LogP value.,O=C(COc1ccccc1Cl)NCCCN1CCOCC1,1.5572999999999997
110629,Please modify the molecule CC(=O)O[C@H]1C[C@@H]2[C@@H]3CC[C@H](C(C)=O)[C@@]3(C)C[C@@H](OC(C)=O)[C@H]2[C@@]2(C)CCC(=O)C[C@H]12 to decrease its LogP value.,CC(=O)O[C@H]1C[C@@H]2[C@@H]3CC[C@H](C(C)=O)[C@@]3(C)C[C@@H](OC(C)=O)[C@H]2[C@@]2(C)CCC(=O)C[C@H]12,3.886600000000003
150725,Please modify the molecule COc1ccc(C(=O)CCC(=O)N(C)[C@H]2CCc3ccccc32)cc1F to decrease its LogP value.,COc1ccc(C(=O)CCC(=O)N(C)[C@H]2CCc3ccccc32)cc1F,3.943100000000003
24352,Modify the molecule Cc1ccoc1[C@H]([NH3+])[C@@H](C)c1ccncc1 to have a lower LogP value.,Cc1ccoc1[C@H]([NH3+])[C@@H](C)c1ccncc1,2.06972
241627,Modify the molecule CN(C)C(=O)COc1ccc(NC(=O)c2cn3cccnc3n2)cc1 to decrease its LogP value.,CN(C)C(=O)COc1ccc(NC(=O)c2cn3cccnc3n2)cc1,1.4485999999999997
9562,Optimize the molecule Cc1cscc1[C@H]([NH3+])c1cc(F)cc(F)c1 to have a lower LogP value.,Cc1cscc1[C@H]([NH3+])c1cc(F)cc(F)c1,2.6660200000000005
26424,Please modify the molecule C[C@@]1([C@H](O)c2ccccc2F)CCCO1 to decrease its LogP value.,C[C@@]1([C@H](O)c2ccccc2F)CCCO1,2.4282000000000004
153724,Optimize the molecule C[C@H](NC(=O)C(=O)Nc1ccc2c(c1)OCCO2)c1ccc(F)c(F)c1 to have a lower LogP value.,C[C@H](NC(=O)C(=O)Nc1ccc2c(c1)OCCO2)c1ccc(F)c(F)c1,2.5519000000000007
99037,Please modify the molecule CN(C(=O)Nc1cccc(-c2nnc3n2CCC3)c1)C1CCCCC1 to increase its LogP value.,CN(C(=O)Nc1cccc(-c2nnc3n2CCC3)c1)C1CCCCC1,3.687700000000002
13841,Modify the molecule COc1ccc2cc(Br)ccc2c1CC(=O)Nc1nc(C)cs1 to decrease its LogP value.,COc1ccc2cc(Br)ccc2c1CC(=O)Nc1nc(C)cs1,4.557020000000003
47229,Optimize the molecule CNc1ncc(C(=O)NCCC(=O)NC2CC2)cc1Cl to have a lower LogP value.,CNc1ncc(C(=O)NCCC(=O)NC2CC2)cc1Cl,1.1752
154521,Please optimize the molecule CC[C@H](O)[C@H]1CCCS(=O)(=O)C1 to have a lower LogP value.,CC[C@H](O)[C@H]1CCCS(=O)(=O)C1,0.5821000000000001
139596,Modify the molecule COc1ccc(OCCC(CO)CO)cc1 to increase its LogP value.,COc1ccc(OCCC(CO)CO)cc1,1.0649
156578,Optimize the molecule CCNC(=O)C1(c2ccc(NS(=O)(=O)CC)cc2)CCC1 to have a higher LogP value.,CCNC(=O)C1(c2ccc(NS(=O)(=O)CC)cc2)CCC1,2.0059999999999993
48989,Modify the molecule CC1=C(c2ccc(C)c(C)c2)S(=O)(=O)N=C1N1CCC(C(=O)NCc2ccco2)CC1 to have a higher LogP value.,CC1=C(c2ccc(C)c(C)c2)S(=O)(=O)N=C1N1CCC(C(=O)NCc2ccco2)CC1,3.3977400000000024
229798,Optimize the molecule CC[C@@H](CNCc1csc(Br)c1)[NH+]1CCCC1 to have a higher LogP value.,CC[C@@H](CNCc1csc(Br)c1)[NH+]1CCCC1,2.0575
182751,Modify the molecule O=C(Nc1cccc2ccccc12)N1CCCN2CCC[NH+]=C21 to have a lower LogP value.,O=C(Nc1cccc2ccccc12)N1CCCN2CCC[NH+]=C21,1.2196999999999996
206566,Please optimize the molecule C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H]1CC[NH+](C2CCCC2)C1 to have a lower LogP value.,C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H]1CC[NH+](C2CCCC2)C1,-0.8946599999999967
173976,Please modify the molecule O=C(NCc1ccccc1)c1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1 to decrease its LogP value.,O=C(NCc1ccccc1)c1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1,4.261600000000003
200871,Modify the molecule COc1ccccc1NC(=S)N/C(=N\c1nc(C)cc(C)n1)N1CCc2ccccc2C1 to have a lower LogP value.,COc1ccccc1NC(=S)N/C(=N\c1nc(C)cc(C)n1)N1CCc2ccccc2C1,4.134440000000003
122035,Modify the molecule CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O to have a lower LogP value.,CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O,1.6431999999999998
202817,Optimize the molecule O=C1[C@H]2[C@H](c3ccccc3)OC3(C(=O)c4ccccc4C3=O)[C@@H]2C(=O)N1c1ccc(Cl)c(Cl)c1 to have a higher LogP value.,O=C1[C@H]2[C@H](c3ccccc3)OC3(C(=O)c4ccccc4C3=O)[C@@H]2C(=O)N1c1ccc(Cl)c(Cl)c1,4.688500000000003
155046,Modify the molecule CC(C)COC[C@H](C)NC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCCC1 to decrease its LogP value.,CC(C)COC[C@H](C)NC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCCC1,2.5925000000000002
37367,Please modify the molecule CN[C@@H](c1cncnc1)C(C)(C)[NH+]1CCCC1 to decrease its LogP value.,CN[C@@H](c1cncnc1)C(C)(C)[NH+]1CCCC1,0.19440000000000057
170919,Modify the molecule CC[C@H](CCO)CNc1ncnc(Cl)c1C to have a lower LogP value.,CC[C@H](CCO)CNc1ncnc(Cl)c1C,2.25892
76323,Modify the molecule COC1CCN(c2cc[nH+]c(C(=O)[O-])c2)CC1 to have a higher LogP value.,COC1CCN(c2cc[nH+]c(C(=O)[O-])c2)CC1,-0.5205999999999997
162168,Please modify the molecule CCOC(=O)c1nnc2c(-c3ccc(Br)cc3)c(COC)nn2c1N to decrease its LogP value.,CCOC(=O)c1nnc2c(-c3ccc(Br)cc3)c(COC)nn2c1N,2.4590999999999994
33227,Modify the molecule O=C(Nc1nc2ccccc2[nH]1)C1CCN(C(=O)C2CC2)CC1 to increase its LogP value.,O=C(Nc1nc2ccccc2[nH]1)C1CCN(C(=O)C2CC2)CC1,2.1500000000000004
200419,Modify the molecule Cc1ccccc1NC(=O)NC[C@@H](c1ccccc1)N1C(=O)c2ccccc2C1=O to decrease its LogP value.,Cc1ccccc1NC(=O)NC[C@@H](c1ccccc1)N1C(=O)c2ccccc2C1=O,4.154020000000003
60442,Please modify the molecule Cc1nc(-c2cccs2)c(CCC(=O)Nc2ccc(C#N)cc2)s1 to increase its LogP value.,Cc1nc(-c2cccs2)c(CCC(=O)Nc2ccc(C#N)cc2)s1,4.623000000000003
227025,Please modify the molecule Cc1cc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)c2ccccc2n1 to decrease its LogP value.,Cc1cc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)c2ccccc2n1,1.0030200000000018
95104,Optimize the molecule O=C(Cc1ccon1)N1CCCN(Cc2ccccc2)c2ccccc21 to have a lower LogP value.,O=C(Cc1ccon1)N1CCCN(Cc2ccccc2)c2ccccc21,3.6606000000000023
53136,Modify the molecule CC(C)(C)S(=O)(=O)CC(=O)NCc1ccc(-c2ccccc2C#N)cc1 to have a lower LogP value.,CC(C)(C)S(=O)(=O)CC(=O)NCc1ccc(-c2ccccc2C#N)cc1,3.054780000000002
35102,Optimize the molecule COc1c(F)cc(F)c(C(=O)[O-])c1F to have a lower LogP value.,COc1c(F)cc(F)c(C(=O)[O-])c1F,0.4760000000000001
141980,Modify the molecule Cc1nccn1C(=O)c1nn(C)c2c1COc1ccccc1-2 to decrease its LogP value.,Cc1nccn1C(=O)c1nn(C)c2c1COc1ccccc1-2,2.1729199999999995
8994,Please optimize the molecule O=C(N[C@H]1CCCC[NH2+]C1)c1n[nH]c(C2CC2)n1 to have a lower LogP value.,O=C(N[C@H]1CCCC[NH2+]C1)c1n[nH]c(C2CC2)n1,-0.47219999999999906
212195,Optimize the molecule CCCS(=O)(=O)N1CCC[C@@H](C(=O)NCc2ccc(N(C)C)cc2)C1 to have a lower LogP value.,CCCS(=O)(=O)N1CCC[C@@H](C(=O)NCc2ccc(N(C)C)cc2)C1,1.8205999999999996
105947,Modify the molecule Cc1ccc(Cl)cc1N1CCN(CC(=O)c2ccc3c(c2)OCO3)CC1 to have a lower LogP value.,Cc1ccc(Cl)cc1N1CCN(CC(=O)c2ccc3c(c2)OCO3)CC1,3.3820200000000016
245610,Modify the molecule C[C@@H]1CCCCN1C(=O)CN1CCN([C@@H](C(=O)N2CCCCC2)c2ccccc2)CC1 to have a higher LogP value.,C[C@@H]1CCCCN1C(=O)CN1CCN([C@@H](C(=O)N2CCCCC2)c2ccccc2)CC1,2.758800000000001
206418,Modify the molecule C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1 to have a higher LogP value.,C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1,1.9771000000000003
108044,Modify the molecule Cn1cc(C(=O)N2CCN(CCO)[C@@H]3CS(=O)(=O)C[C@@H]32)c2ccccc21 to have a lower LogP value.,Cn1cc(C(=O)N2CCN(CCO)[C@@H]3CS(=O)(=O)C[C@@H]32)c2ccccc21,0.09400000000000164
82825,Optimize the molecule CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1 to have a higher LogP value.,CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1,1.6260999999999994
246837,Modify the molecule Fc1cnccc1-c1nc([C@@H]2CCOC2)no1 to decrease its LogP value.,Fc1cnccc1-c1nc([C@@H]2CCOC2)no1,1.7745999999999997
113606,Optimize the molecule CCCCc1noc(C[C@@H](C)O)n1 to have a higher LogP value.,CCCCc1noc(C[C@@H](C)O)n1,1.3355
149837,Modify the molecule COCCS[C@@H]1C[C@H](C)CC[C@H]1C#N to have a lower LogP value.,COCCS[C@@H]1C[C@H](C)CC[C@H]1C#N,2.6943800000000007
5151,Modify the molecule COc1ccccc1-n1nnnc1S[C@@H](C)C(=O)Nc1cccc(Cl)c1C to increase its LogP value.,COc1ccccc1-n1nnnc1S[C@@H](C)C(=O)Nc1cccc(Cl)c1C,3.7520200000000026
210236,Modify the molecule C[C@@H]1C[C@@H]1COC(=O)[C@@H](C)N1CCc2ccccc2C1 to have a lower LogP value.,C[C@@H]1C[C@@H]1COC(=O)[C@@H](C)N1CCc2ccccc2C1,2.6324000000000014
113570,Please modify the molecule N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N to increase its LogP value.,N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N,3.4025800000000004
173894,Please modify the molecule CCN(Cc1cccc(C)n1)C(=O)[C@H]([NH3+])CC(N)=O to increase its LogP value.,CCN(Cc1cccc(C)n1)C(=O)[C@H]([NH3+])CC(N)=O,-0.7755799999999975
214504,Optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1C(=O)NC(C)(C)C to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1C(=O)NC(C)(C)C,3.9151000000000025
96364,Optimize the molecule Cc1cccc(NC(=O)C(=O)NCC2CC[NH+](Cc3cccs3)CC2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)C(=O)NCC2CC[NH+](Cc3cccs3)CC2)c1,1.6063200000000002
112116,Modify the molecule COc1ccc(Cl)cc1NC(=O)C(=O)NC[C@H](c1ccc2c(c1)CCN2C)[NH+]1CCCC1 to decrease its LogP value.,COc1ccc(Cl)cc1NC(=O)C(=O)NC[C@H](c1ccc2c(c1)CCN2C)[NH+]1CCCC1,1.8155999999999994
68919,Modify the molecule CC(=O)Oc1ccc(C(=O)Nc2ccc(-c3nc4ccccc4[nH]3)cc2)cc1 to have a higher LogP value.,CC(=O)Oc1ccc(C(=O)Nc2ccc(-c3nc4ccccc4[nH]3)cc2)cc1,4.407500000000002
90399,Please optimize the molecule CC(=O)N[C@H](/C([O-])=N/S(=O)(=O)c1ccc(C)cc1)C1CCCC1 to have a lower LogP value.,CC(=O)N[C@H](/C([O-])=N/S(=O)(=O)c1ccc(C)cc1)C1CCCC1,1.13742
210222,Modify the molecule COC(=O)C1=C(CN2CCN(c3ccc(F)cc3)CC2)NC(=O)N[C@@H]1c1cccc(Cl)c1 to increase its LogP value.,COC(=O)C1=C(CN2CCN(c3ccc(F)cc3)CC2)NC(=O)N[C@@H]1c1cccc(Cl)c1,3.0823
165362,Please optimize the molecule Cc1nc(C)n([C@H]2CCCN(C(=O)[C@@H]3CCS(=O)(=O)C3)C2)n1 to have a higher LogP value.,Cc1nc(C)n([C@H]2CCCN(C(=O)[C@@H]3CCS(=O)(=O)C3)C2)n1,0.49314000000000013
194715,Modify the molecule CC(=O)Nc1ccc(Cl)c(NS(=O)(=O)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c1 to have a higher LogP value.,CC(=O)Nc1ccc(Cl)c(NS(=O)(=O)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c1,3.895400000000002
215417,Modify the molecule COC[C@H](O)CNc1nc2ccc(N)cc2o1 to have a lower LogP value.,COC[C@H](O)CNc1nc2ccc(N)cc2o1,0.8291999999999999
7360,Please optimize the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)CCC(=O)c2ccc3c(c2)CCC3)C1 to have a lower LogP value.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)CCC(=O)c2ccc3c(c2)CCC3)C1,1.3200000000000003
47167,Modify the molecule C[C@H](NC(=O)c1ccco1)c1nc2ccccc2n1[C@H](C)c1ccccc1 to decrease its LogP value.,C[C@H](NC(=O)c1ccco1)c1nc2ccccc2n1[C@H](C)c1ccccc1,4.729600000000004
209637,Please modify the molecule CCONC(=O)c1cnc2sc(C)cn2c1=O to decrease its LogP value.,CCONC(=O)c1cnc2sc(C)cn2c1=O,0.7457199999999999
73300,Modify the molecule CCN(CCC#N)C(=O)Nc1ccc(OCc2ccccn2)c(F)c1 to have a higher LogP value.,CCN(CCC#N)C(=O)Nc1ccc(OCc2ccccn2)c(F)c1,3.5671800000000022
66172,Modify the molecule C[C@H]1OCC[C@@H]1C(=O)N1C[C@H](CC[NH3+])c2ccccc21 to have a higher LogP value.,C[C@H]1OCC[C@@H]1C(=O)N1C[C@H](CC[NH3+])c2ccccc21,1.173800000000001
199507,Please optimize the molecule CCO[C@@H](C)c1noc(CS[C@@H](C)c2ccc3ccccc3c2)n1 to have a lower LogP value.,CCO[C@@H](C)c1noc(CS[C@@H](C)c2ccc3ccccc3c2)n1,5.3147000000000055
1350,Modify the molecule CC1=[N+](c2ccc(C)cc2)C(SCC(=O)Nc2cccc(C(F)(F)F)c2)=NC(C)(C)C1 to have a lower LogP value.,CC1=[N+](c2ccc(C)cc2)C(SCC(=O)Nc2cccc(C(F)(F)F)c2)=NC(C)(C)C1,6.028920000000005
166551,Modify the molecule CCCSCc1cc(F)cc(Br)c1 to have a higher LogP value.,CCCSCc1cc(F)cc(Br)c1,4.2314000000000025
49946,Please optimize the molecule Cc1cccc(S(=O)(=O)[C@H](C)C(=O)Nc2cc(F)ccc2F)c1 to have a lower LogP value.,Cc1cccc(S(=O)(=O)[C@H](C)C(=O)Nc2cc(F)ccc2F)c1,3.0741200000000015
169794,Optimize the molecule O=C(NCCNC(=O)C1CC1)N[C@@H]1CCO[C@@H]1c1ccc(Cl)cc1 to have a lower LogP value.,O=C(NCCNC(=O)C1CC1)N[C@@H]1CCO[C@@H]1c1ccc(Cl)cc1,1.9954000000000003
84897,Optimize the molecule Cc1ccc(CC(=O)N2CCC(c3c[nH]c4ncccc34)CC2)cn1 to have a higher LogP value.,Cc1ccc(CC(=O)N2CCC(c3c[nH]c4ncccc34)CC2)cn1,3.2150200000000018
93337,Please modify the molecule CCOC(=O)NNC(=O)c1ccc(C[NH+](C)C)cc1 to increase its LogP value.,CCOC(=O)NNC(=O)c1ccc(C[NH+](C)C)cc1,-0.2779999999999987
20336,Optimize the molecule O=C(N/N=C/c1cccc(Cl)c1)c1ccc(CN2CCc3ccccc3C2)cc1 to have a higher LogP value.,O=C(N/N=C/c1cccc(Cl)c1)c1ccc(CN2CCc3ccccc3C2)cc1,4.662200000000004
123641,Modify the molecule CN(C)c1nc(Cl)nc(NCCC(=O)NC2CC2)n1 to have a lower LogP value.,CN(C)c1nc(Cl)nc(NCCC(=O)NC2CC2)n1,0.6715999999999995
53740,Optimize the molecule O=C(NCc1ccncc1)[C@H]1CCCC[NH2+]1 to have a lower LogP value.,O=C(NCc1ccncc1)[C@H]1CCCC[NH2+]1,-0.18630000000000002
17290,Modify the molecule COc1ccc([C@@H](C(=O)[O-])[C@H](C(=O)[O-])c2ccccc2)cc1 to have a higher LogP value.,COc1ccc([C@@H](C(=O)[O-])[C@H](C(=O)[O-])c2ccccc2)cc1,0.06240000000000001
124642,Modify the molecule CCCN(CC#N)Cc1cn(C)nc1-c1ccc2c(c1)OCCCO2 to increase its LogP value.,CCCN(CC#N)Cc1cn(C)nc1-c1ccc2c(c1)OCCCO2,2.9839800000000016
245220,Optimize the molecule O[C@@H]1C=C([C@H]2CCc3cccnc32)CCC1 to have a higher LogP value.,O[C@@H]1C=C([C@H]2CCc3cccnc32)CCC1,2.582600000000001
58439,Modify the molecule O=[N+]([O-])c1cc2c(c(CSc3nc(-c4ccccc4)n[nH]3)c1)OCOC2 to decrease its LogP value.,O=[N+]([O-])c1cc2c(c(CSc3nc(-c4ccccc4)n[nH]3)c1)OCOC2,3.538700000000002
85585,Optimize the molecule CC(C)Cc1noc(CN2C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)n1 to have a higher LogP value.,CC(C)Cc1noc(CN2C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)n1,3.097800000000002
47284,Please optimize the molecule C[C@H]1CCC[C@@]([C@H](O)CCCS(C)(=O)=O)([NH+](C)C)C1 to have a higher LogP value.,C[C@H]1CCC[C@@]([C@H](O)CCCS(C)(=O)=O)([NH+](C)C)C1,0.26550000000000185
136621,Modify the molecule Cc1ccc(Oc2ccc(NC(=O)[C@@H]3CCS(=O)(=O)C3)cn2)cc1 to increase its LogP value.,Cc1ccc(Oc2ccc(NC(=O)[C@@H]3CCS(=O)(=O)C3)cn2)cc1,2.5555200000000005
161801,Please optimize the molecule Cc1cc(N2CCOCC2)ccc1NC(=O)C(=O)N[C@H]1CCC[C@H](C)[C@@H]1C to have a higher LogP value.,Cc1cc(N2CCOCC2)ccc1NC(=O)C(=O)N[C@H]1CCC[C@H](C)[C@@H]1C,2.7110200000000004
93575,Please optimize the molecule Cc1ccc2nc(CC(=O)c3ccoc3C)[nH]c(=O)c2c1 to have a higher LogP value.,Cc1ccc2nc(CC(=O)c3ccoc3C)[nH]c(=O)c2c1,2.5583400000000003
89874,Modify the molecule C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H](C)c1ccccc1 to decrease its LogP value.,C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H](C)c1ccccc1,1.26674
40559,Optimize the molecule C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)N1CCO[C@H]2CCCC[C@@H]21 to have a lower LogP value.,C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)N1CCO[C@H]2CCCC[C@@H]21,0.8597000000000006
144936,Please optimize the molecule C[C@@H](Cc1nnc(NC(=O)Cc2ccc(F)cc2)s1)c1ccccc1 to have a higher LogP value.,C[C@@H](Cc1nnc(NC(=O)Cc2ccc(F)cc2)s1)c1ccccc1,4.204600000000003
185016,Modify the molecule Cn1ncnc1CCNC(=O)Nc1ccc(F)cc1-c1ccc(F)cc1 to increase its LogP value.,Cn1ncnc1CCNC(=O)Nc1ccc(F)cc1-c1ccc(F)cc1,3.124500000000001
21552,Optimize the molecule CC1(C)CC(=O)C2=C(C1)Nc1[nH]c(=O)[nH]c(=O)c1[C@@H]2c1ccc(Br)s1 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)Nc1[nH]c(=O)[nH]c(=O)c1[C@@H]2c1ccc(Br)s1,3.0878000000000005
244487,Modify the molecule CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl to have a lower LogP value.,CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl,1.0104000000000002
147748,Modify the molecule CC(C)c1cc(C(=O)N2CCSCC2)on1 to increase its LogP value.,CC(C)c1cc(C(=O)N2CCSCC2)on1,1.987
58806,Please modify the molecule N#Cc1ccc(NC(=O)CCCC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1 to increase its LogP value.,N#Cc1ccc(NC(=O)CCCC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1,3.154980000000002
232477,Please optimize the molecule COC(C)(C)CNC(=O)NC[C@H](O)c1ccc2ccccc2c1 to have a lower LogP value.,COC(C)(C)CNC(=O)NC[C@H](O)c1ccc2ccccc2c1,2.5974000000000004
193867,Optimize the molecule CCN[C@@H](Cc1ccc(O)cc1)[C@@](C)(CC)[NH+]1CCCC1 to have a higher LogP value.,CCN[C@@H](Cc1ccc(O)cc1)[C@@](C)(CC)[NH+]1CCCC1,1.7601999999999998
6497,Modify the molecule CCCC1=C(C(=O)OCC)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=O)N1C to decrease its LogP value.,CCCC1=C(C(=O)OCC)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=O)N1C,2.908200000000001
90162,Please optimize the molecule C[C@@H]([NH3+])CCNC(=O)c1ccncc1Cl to have a higher LogP value.,C[C@@H]([NH3+])CCNC(=O)c1ccncc1Cl,0.4853000000000001
242192,Modify the molecule CCCS(=O)(=O)N1CCC[C@H](C(=O)N2CCC([NH+](C)C)CC2)C1 to have a lower LogP value.,CCCS(=O)(=O)N1CCC[C@H](C(=O)N2CCC([NH+](C)C)CC2)C1,-0.4262999999999959
111317,Please optimize the molecule CC1(C)C(=O)N([C@H]2COC[C@@H]2C(=O)[O-])S1(=O)=O to have a higher LogP value.,CC1(C)C(=O)N([C@H]2COC[C@@H]2C(=O)[O-])S1(=O)=O,-2.298099999999998
176099,Modify the molecule O=C(CCC(=O)c1ccc2c(c1)CCC2)Nc1ccc2c(c1)OC1(CCCC1)O2 to decrease its LogP value.,O=C(CCC(=O)c1ccc2c(c1)CCC2)Nc1ccc2c(c1)OC1(CCCC1)O2,4.818400000000004
97776,Modify the molecule CC(=O)C[C@@H]1CCC[NH+]1Cc1cccnc1 to increase its LogP value.,CC(=O)C[C@@H]1CCC[NH+]1Cc1cccnc1,0.6079999999999997
10036,Please modify the molecule O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O to increase its LogP value.,O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O,1.9755999999999996
167885,Please optimize the molecule CC(C)C[NH2+]Cc1ccc(Br)cc1-n1ccnc1C#N to have a lower LogP value.,CC(C)C[NH2+]Cc1ccc(Br)cc1-n1ccnc1C#N,2.22588
90988,Please modify the molecule N[C@@H](c1ccc([S-])cc1O)C(F)(F)F to increase its LogP value.,N[C@@H](c1ccc([S-])cc1O)C(F)(F)F,1.8601000000000005
107577,Optimize the molecule CS(=O)(=O)CCN1CCN(c2[nH]c3ccccc3[nH+]2)CC1 to have a higher LogP value.,CS(=O)(=O)CCN1CCN(c2[nH]c3ccccc3[nH+]2)CC1,0.14860000000000145
239264,Modify the molecule COc1cc2c3nc4n(c(=O)c3n(CC(=O)NC(C)C)c2cc1OC)CCS4 to increase its LogP value.,COc1cc2c3nc4n(c(=O)c3n(CC(=O)NC(C)C)c2cc1OC)CCS4,1.9986999999999995
77853,Please optimize the molecule NC(=O)c1n[nH]c2ccc(NC(=O)C3CCN(c4cnccn4)CC3)cc12 to have a lower LogP value.,NC(=O)c1n[nH]c2ccc(NC(=O)C3CCN(c4cnccn4)CC3)cc12,1.3068999999999986
219352,Please modify the molecule C[C@@H](NC(=O)CS(=O)(=O)c1nncn1C)c1ccc(Br)cc1 to decrease its LogP value.,C[C@@H](NC(=O)CS(=O)(=O)c1nncn1C)c1ccc(Br)cc1,1.2287000000000006
80947,Please modify the molecule [NH3+]C1(C(=O)N2[C@H]3CCCC[C@H]3CC[C@@H]2C(=O)[O-])CC1 to increase its LogP value.,[NH3+]C1(C(=O)N2[C@H]3CCCC[C@H]3CC[C@@H]2C(=O)[O-])CC1,-0.9393999999999985
45719,Please optimize the molecule COc1ccc(CCC(=O)NCc2ccccc2Cl)cc1OC to have a higher LogP value.,COc1ccc(CCC(=O)NCc2ccccc2Cl)cc1OC,3.606200000000002
24534,Modify the molecule Cc1ccc(NC(=O)[C@H]2CCC[NH+](Cc3cccc4cn[nH]c34)C2)nc1 to have a higher LogP value.,Cc1ccc(NC(=O)[C@H]2CCC[NH+](Cc3cccc4cn[nH]c34)C2)nc1,1.6999199999999992
79931,Optimize the molecule CCn1cc(C[NH+]2CCC(C(=O)NCc3ccccc3)CC2)c2cc(OC)ccc21 to have a higher LogP value.,CCn1cc(C[NH+]2CCC(C(=O)NCc3ccccc3)CC2)c2cc(OC)ccc21,2.7811000000000012
183918,Optimize the molecule O=C(NCC1(c2ccc(Cl)cc2)CC1)NOCc1ccccc1 to have a higher LogP value.,O=C(NCC1(c2ccc(Cl)cc2)CC1)NOCc1ccccc1,3.8026000000000026
220326,Please optimize the molecule Cc1cccc(O[C@H](C)C(=O)N/N=C/c2ccco2)c1 to have a lower LogP value.,Cc1cccc(O[C@H](C)C(=O)N/N=C/c2ccco2)c1,2.5056200000000004
90536,Please modify the molecule COc1ccc2cc(C(=O)N[C@H]3C[C@H]3C)c(C)nc2c1 to decrease its LogP value.,COc1ccc2cc(C(=O)N[C@H]3C[C@H]3C)c(C)nc2c1,2.6900200000000005
143166,Modify the molecule O=C(NNc1ccccc1)[C@H]1CCCN(S(=O)(=O)c2cccs2)C1 to have a lower LogP value.,O=C(NNc1ccccc1)[C@H]1CCCN(S(=O)(=O)c2cccs2)C1,2.2921000000000005
61730,Please modify the molecule O=C([O-])[C@H]1Cc2[nH]c[nH+]c2CN1C(=O)CC12CC3CC(CC(C3)C1)C2 to increase its LogP value.,O=C([O-])[C@H]1Cc2[nH]c[nH+]c2CN1C(=O)CC12CC3CC(CC(C3)C1)C2,0.43849999999999967
18982,Optimize the molecule CSc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1NC(C)=O to have a lower LogP value.,CSc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1NC(C)=O,2.8458000000000006
11064,Modify the molecule Cc1ccc(F)cc1NC(=O)CSc1nnc(-c2cccnc2)o1 to have a lower LogP value.,Cc1ccc(F)cc1NC(=O)CSc1nnc(-c2cccnc2)o1,3.309920000000001
147987,Optimize the molecule CC(=O)c1ccccc1-c1ccc(C(=O)NC[C@H]2CC[NH+](CC(C)C)C2)cn1 to have a higher LogP value.,CC(=O)c1ccccc1-c1ccc(C(=O)NC[C@H]2CC[NH+](CC(C)C)C2)cn1,2.2417999999999996
106150,Optimize the molecule CCCNC(=O)CN(C)C(=O)CN1CC[C@H]([NH3+])[C@H](C)C1 to have a higher LogP value.,CCCNC(=O)CN(C)C(=O)CN1CC[C@H]([NH3+])[C@H](C)C1,-1.0766999999999967
114461,Modify the molecule CN(C(=O)CN1CC[NH2+]CC1)C1CCC(C)(C)CC1 to decrease its LogP value.,CN(C(=O)CN1CC[NH2+]CC1)C1CCC(C)(C)CC1,0.2926000000000013
41838,Please optimize the molecule COc1ccc(Br)c(C=O)c1NC(C)=O to have a lower LogP value.,COc1ccc(Br)c(C=O)c1NC(C)=O,2.2286
58943,Modify the molecule CN(Cc1ccccc1)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)cc1 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)cc1,4.733400000000004
83725,Please modify the molecule Cc1cc(I)ccc1NC(=O)CCC(=O)N/N=C/c1ccc(N(C)C)cc1 to decrease its LogP value.,Cc1cc(I)ccc1NC(=O)CCC(=O)N/N=C/c1ccc(N(C)C)cc1,3.534620000000002
132507,Optimize the molecule COc1ccc(NC(=O)c2ccc(COc3ccccc3Cl)o2)cc1OC to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(COc3ccccc3Cl)o2)cc1OC,4.781500000000004
137895,Modify the molecule Cc1nn(C)c2nc(C3CC3)cc(C(=O)N(c3ccccc3)C(C)C)c12 to have a lower LogP value.,Cc1nn(C)c2nc(C3CC3)cc(C(=O)N(c3ccccc3)C(C)C)c12,4.2093200000000035
96489,Please modify the molecule O=C(CCSc1nc2ccccc2[nH]1)N1CCOCC1 to increase its LogP value.,O=C(CCSc1nc2ccccc2[nH]1)N1CCOCC1,1.9039000000000001
154599,Please optimize the molecule CCC(=O)Nc1ccc(C)c(NC(=O)NCC2(N3CCOCC3)CCCCC2)c1 to have a lower LogP value.,CCC(=O)Nc1ccc(C)c(NC(=O)NCC2(N3CCOCC3)CCCCC2)c1,3.5001200000000017
4047,Please modify the molecule O=C(Cc1cc2ccccc2[nH]1)N/N=C/c1c[nH]c2ccccc12 to increase its LogP value.,O=C(Cc1cc2ccccc2[nH]1)N/N=C/c1c[nH]c2ccccc12,3.3420000000000014
202889,Modify the molecule C[C@@]1(C2CCN(C(=O)/C=C/c3cc(F)cc(F)c3)CC2)NC(=O)N(Cc2ccncc2)C1=O to increase its LogP value.,C[C@@]1(C2CCN(C(=O)/C=C/c3cc(F)cc(F)c3)CC2)NC(=O)N(Cc2ccncc2)C1=O,3.122300000000002
142500,Modify the molecule C[C@H](c1ccc(NCc2cn(C)nc2C(C)(C)C)cc1)N1CCOCC1 to decrease its LogP value.,C[C@H](c1ccc(NCc2cn(C)nc2C(C)(C)C)cc1)N1CCOCC1,3.7229000000000028
100184,Please modify the molecule CO[C@]1(C)C[C@@H](N(C)C(=O)NCC(=O)N(C)C)C1(C)C to decrease its LogP value.,CO[C@]1(C)C[C@@H](N(C)C(=O)NCC(=O)N(C)C)C1(C)C,0.9196000000000004
57663,Modify the molecule Cc1cc(-n2cnnc2)cc(C)c1NC(=O)c1ccccc1 to decrease its LogP value.,Cc1cc(-n2cnnc2)cc(C)c1NC(=O)c1ccccc1,3.1364400000000012
164686,Optimize the molecule Clc1ccc(OCc2nn3c(-c4cccnc4)nnc3s2)cc1 to have a higher LogP value.,Clc1ccc(OCc2nn3c(-c4cccnc4)nnc3s2)cc1,3.4802000000000017
225958,Modify the molecule Oc1c(F)ccc2cc[nH]c12 to decrease its LogP value.,Oc1c(F)ccc2cc[nH]c12,2.0125999999999995
153935,Optimize the molecule CCn1ccnc(N(C)CC(=O)NC2CC2)c1=O to have a lower LogP value.,CCn1ccnc(N(C)CC(=O)NC2CC2)c1=O,-0.02200000000000002
117419,Optimize the molecule O=S1(=O)CCC([NH2+][C@H]2CCC[C@H]2[C@@H]2CCC[NH2+]2)CC1 to have a higher LogP value.,O=S1(=O)CCC([NH2+][C@H]2CCC[C@H]2[C@@H]2CCC[NH2+]2)CC1,-0.9784999999999962
168333,Modify the molecule CC(C)([C@@H](O)[C@@H]1CCOC2(CCC2)C1)N1CCOCC1 to have a lower LogP value.,CC(C)([C@@H](O)[C@@H]1CCOC2(CCC2)C1)N1CCOCC1,1.8074
134358,Please modify the molecule O=C(CSc1cccc2cccnc12)Nc1ccc(Br)cc1 to increase its LogP value.,O=C(CSc1cccc2cccnc12)Nc1ccc(Br)cc1,4.728100000000002
213289,Modify the molecule Cc1nn(CC(=O)Nc2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c(C)c1Cl to have a lower LogP value.,Cc1nn(CC(=O)Nc2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c(C)c1Cl,3.642640000000002
200493,Modify the molecule CC[NH+]1CCCC[C@@H]1CNC(=O)C[C@@H](C)NC(=O)C1CCCC1 to increase its LogP value.,CC[NH+]1CCCC[C@@H]1CNC(=O)C[C@@H](C)NC(=O)C1CCCC1,0.6449000000000018
70887,Optimize the molecule Cc1c(CC(=O)N(C)C2CCCCC2)c2c(n1C[C@H]1CCCO1)CCCC2=O to have a higher LogP value.,Cc1c(CC(=O)N(C)C2CCCCC2)c2c(n1C[C@H]1CCCO1)CCCC2=O,3.828120000000003
142591,Optimize the molecule C#CCNCC(=O)N1CCN(CC(F)(F)F)CC1 to have a higher LogP value.,C#CCNCC(=O)N1CCN(CC(F)(F)F)CC1,-0.08430000000000026
194363,Please modify the molecule CC(C)[NH+](C)CCNC(=O)C[C@H](O)c1ccccc1 to decrease its LogP value.,CC(C)[NH+](C)CCNC(=O)C[C@H](O)c1ccccc1,0.14940000000000114
26491,Optimize the molecule N#Cc1cccc(-c2ccnc(C(=O)[O-])c2)c1F to have a higher LogP value.,N#Cc1cccc(-c2ccnc(C(=O)[O-])c2)c1F,1.1228799999999999
176139,Please modify the molecule C[C@@H](CC(=O)Nc1cccc(OCC#N)c1)CC(C)(C)C to increase its LogP value.,C[C@@H](CC(=O)Nc1cccc(OCC#N)c1)CC(C)(C)C,3.989880000000003
113733,Optimize the molecule C=CCOc1c(CNc2ccc(N3CCCC3)cc2C)c(C)nn1C to have a lower LogP value.,C=CCOc1c(CNc2ccc(N3CCCC3)cc2C)c(C)nn1C,3.814040000000003
136561,Modify the molecule Cc1c2c(cc3c1O/C(=C\c1ccccc1Br)C3=O)CN(Cc1cccnc1)CO2 to increase its LogP value.,Cc1c2c(cc3c1O/C(=C\c1ccccc1Br)C3=O)CN(Cc1cccnc1)CO2,5.120820000000005
113348,Please modify the molecule N#C[C@H]1COCCN1Cc1ccc(F)cc1F to decrease its LogP value.,N#C[C@H]1COCCN1Cc1ccc(F)cc1F,1.6891800000000001
46973,Modify the molecule O=C(NCCc1ccccn1)[C@@H](Sc1ccccc1)c1ccccc1 to have a higher LogP value.,O=C(NCCc1ccccn1)[C@@H](Sc1ccccc1)c1ccccc1,4.273900000000003
39486,Please modify the molecule Cc1cc(C)c(-c2csc(NC(=O)CC3=c4ccccc4=[NH+]C3)n2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(-c2csc(NC(=O)CC3=c4ccccc4=[NH+]C3)n2)c(C)c1,1.6286599999999993
53193,Optimize the molecule COc1cccc(COc2cc(C(C)C)nc(C(C)C)n2)c1 to have a lower LogP value.,COc1cccc(COc2cc(C(C)C)nc(C(C)C)n2)c1,4.3110000000000035
103454,Modify the molecule C[C@H](Oc1ccc(Oc2ccccc2)cc1)C(=O)Nc1ccncc1 to decrease its LogP value.,C[C@H](Oc1ccc(Oc2ccccc2)cc1)C(=O)Nc1ccncc1,4.279900000000002
41944,Modify the molecule COc1ccc(OCC(=O)Nc2cccc3nsnc23)cc1 to have a lower LogP value.,COc1ccc(OCC(=O)Nc2cccc3nsnc23)cc1,2.7174000000000005
64517,Modify the molecule O=C(COc1ccc(F)c(Cl)c1)NCCC[C@H]1CCCC[C@H]1O to increase its LogP value.,O=C(COc1ccc(F)c(Cl)c1)NCCC[C@H]1CCCC[C@H]1O,3.305400000000002
3619,Please optimize the molecule CC1(C)CN(c2nc(C(F)F)nc3ccccc23)CC[S@@]1=O to have a higher LogP value.,CC1(C)CN(c2nc(C(F)F)nc3ccccc23)CC[S@@]1=O,2.9147000000000007
191081,Please modify the molecule CCS(=O)(=O)NCCNC(=O)N1CCC[C@@H](c2[nH]cc[nH+]2)C1 to increase its LogP value.,CCS(=O)(=O)NCCNC(=O)N1CCC[C@@H](c2[nH]cc[nH+]2)C1,-0.342899999999998
149326,Modify the molecule Cc1oc(-c2ccsc2)nc1CC(=O)NCCCc1nnc2n1CCCCC2 to have a lower LogP value.,Cc1oc(-c2ccsc2)nc1CC(=O)NCCCc1nnc2n1CCCCC2,3.320920000000002
144403,Please optimize the molecule C[C@@H](NC(=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1)C1CCCCC1 to have a lower LogP value.,C[C@@H](NC(=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1)C1CCCCC1,3.762900000000003
210473,Modify the molecule N#Cc1c(NC(=O)COc2ncnc3ccccc23)sc2c1CCC2 to have a lower LogP value.,N#Cc1c(NC(=O)COc2ncnc3ccccc23)sc2c1CCC2,3.069180000000001
191111,Modify the molecule COc1cccc(N2C[C@@H](C(=O)N(C)Cc3ccsc3)CC2=O)c1 to have a lower LogP value.,COc1cccc(N2C[C@@H](C(=O)N(C)Cc3ccsc3)CC2=O)c1,2.768200000000001
111446,Modify the molecule O=S(=O)(NCCCn1cncn1)c1ccc2c(c1)CCCC2 to have a higher LogP value.,O=S(=O)(NCCCn1cncn1)c1ccc2c(c1)CCCC2,1.5254999999999992
132080,Modify the molecule COCC(=O)N1CCN(c2ccccc2C#N)CC1 to have a higher LogP value.,COCC(=O)N1CCN(c2ccccc2C#N)CC1,0.8532799999999998
49694,Optimize the molecule CCOc1ccccc1CCC(=O)N1CCOC[C@@H]1C(N)=O to have a higher LogP value.,CCOc1ccccc1CCC(=O)N1CCOC[C@@H]1C(N)=O,0.7306000000000001
22682,Optimize the molecule CN1C(=O)c2ccc(C(=O)Nc3cc([N+](=O)[O-])ccc3O)cc2C1=O to have a lower LogP value.,CN1C(=O)c2ccc(C(=O)Nc3cc([N+](=O)[O-])ccc3O)cc2C1=O,1.7784999999999997
87106,Optimize the molecule Cc1ccc(-c2ncc(C[NH+]3CC[C@H](Cc4cnn(C)c4)C3)s2)cc1 to have a higher LogP value.,Cc1ccc(-c2ncc(C[NH+]3CC[C@H](Cc4cnn(C)c4)C3)s2)cc1,2.4995200000000004
95725,Please modify the molecule CO[C@H](c1ccccc1)c1nc2nc(N(C)C)ccc2[nH]1 to increase its LogP value.,CO[C@H](c1ccccc1)c1nc2nc(N(C)C)ccc2[nH]1,2.7597000000000005
143994,Optimize the molecule CC[C@H]1C[NH+](CC(C)(C)C)Cc2cc(OC)ccc2O1 to have a higher LogP value.,CC[C@H]1C[NH+](CC(C)(C)C)Cc2cc(OC)ccc2O1,2.2972
197533,Please optimize the molecule CCn1cnc(S(=O)(=O)N[C@@H]2CCCC[C@@H]2[NH3+])c1 to have a higher LogP value.,CCn1cnc(S(=O)(=O)N[C@@H]2CCCC[C@@H]2[NH3+])c1,-0.26559999999999845
196410,Please optimize the molecule CC(C)C[C@H](C(=O)NCc1cccc(CO)c1)N1CCCCC1=O to have a higher LogP value.,CC(C)C[C@H](C(=O)NCc1cccc(CO)c1)N1CCCCC1=O,2.2222999999999997
190371,Please modify the molecule CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(C(C)C)cccc3s2)cc1 to increase its LogP value.,CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(C(C)C)cccc3s2)cc1,5.455300000000006
228758,Please modify the molecule Cc1cccn2c(=O)c(/C=N/NC(N)=S)c(N3CCCC3)nc12 to increase its LogP value.,Cc1cccn2c(=O)c(/C=N/NC(N)=S)c(N3CCCC3)nc12,0.7702200000000005
230958,Modify the molecule O=C(Nc1ccccc1Cl)C1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1 to increase its LogP value.,O=C(Nc1ccccc1Cl)C1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,4.398200000000004
113897,Optimize the molecule CCN(CCO)C(=O)NC[C@@H]1CC[NH+](C2CC2)C1 to have a higher LogP value.,CCN(CCO)C(=O)NC[C@@H]1CC[NH+](C2CC2)C1,-0.9225999999999974
178541,Please optimize the molecule C[C@@H]1CN(c2ccc(N)cc2C(=O)[O-])C[C@H]1C to have a higher LogP value.,C[C@@H]1CN(c2ccc(N)cc2C(=O)[O-])C[C@H]1C,0.7244999999999998
234843,Please modify the molecule Cc1ccc(Cc2nnc(NC(=O)c3cncc(C)c3)s2)cc1 to decrease its LogP value.,Cc1ccc(Cc2nnc(NC(=O)c3cncc(C)c3)s2)cc1,3.393040000000002
102550,Please modify the molecule C[C@H](C1CC1)[NH+](C)CC(=O)NCCc1c(F)cccc1F to decrease its LogP value.,C[C@H](C1CC1)[NH+](C)CC(=O)NCCc1c(F)cccc1F,0.9366999999999999
146988,Modify the molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)N[C@@H](C)Cn1cc[nH+]c1 to have a higher LogP value.,CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)N[C@@H](C)Cn1cc[nH+]c1,1.7710999999999997
61768,Modify the molecule Cc1noc(C)c1S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(Cl)c(Cl)c1 to increase its LogP value.,Cc1noc(C)c1S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(Cl)c(Cl)c1,3.780140000000002
81932,Please modify the molecule [O-]c1nnc(-c2ccccn2)[nH]1 to decrease its LogP value.,[O-]c1nnc(-c2ccccn2)[nH]1,-0.05970000000000025
145277,Modify the molecule Cc1nnnn1-c1cccc(C(=O)N2CCC3=C(C2)[C@H](C(C)C)N=N3)c1 to increase its LogP value.,Cc1nnnn1-c1cccc(C(=O)N2CCC3=C(C2)[C@H](C(C)C)N=N3)c1,2.5611200000000007
47213,Please optimize the molecule O=C1NCCCC[C@H]1Oc1ccc(OC(=O)[C@@H]2CCCC[C@@H]2C(F)(F)F)cc1 to have a lower LogP value.,O=C1NCCCC[C@H]1Oc1ccc(OC(=O)[C@@H]2CCCC[C@@H]2C(F)(F)F)cc1,4.008200000000003
138679,Please optimize the molecule Cc1cc([C@@H](C)NC(=O)NNC(=O)c2ccccc2O)cc(C)c1F to have a higher LogP value.,Cc1cc([C@@H](C)NC(=O)NNC(=O)c2ccccc2O)cc(C)c1F,2.853340000000001
8687,Optimize the molecule C[C@@H]1C[C@H]1c1ccc(C[NH+](C)C2CCC([NH3+])CC2)o1 to have a higher LogP value.,C[C@@H]1C[C@H]1c1ccc(C[NH+](C)C2CCC([NH3+])CC2)o1,0.9708000000000012
115889,Modify the molecule COc1cccc2c1OC[C@@H](NC(=O)C1(O)CCCC1)C2 to increase its LogP value.,COc1cccc2c1OC[C@@H](NC(=O)C1(O)CCCC1)C2,1.4199999999999997
163044,Modify the molecule C[C@H]1CC(=O)c2cnn(-c3nc4ccccc4s3)c2C1 to increase its LogP value.,C[C@H]1CC(=O)c2cnn(-c3nc4ccccc4s3)c2C1,3.2470000000000026
16305,Optimize the molecule C[NH2+][C@H](C)c1ccn(CC(=O)NC(C)(C)C)c1 to have a lower LogP value.,C[NH2+][C@H](C)c1ccn(CC(=O)NC(C)(C)C)c1,0.6569999999999996
144540,Optimize the molecule Cc1cc(N2CCn3cc[nH+]c3C2)c([C@H](C)[NH3+])cc1F to have a higher LogP value.,Cc1cc(N2CCn3cc[nH+]c3C2)c([C@H](C)[NH3+])cc1F,1.07282
203746,Please optimize the molecule CC[C@H](C)/[NH+]=C(/N)NCC(C)(C)N1CCOCC1 to have a lower LogP value.,CC[C@H](C)/[NH+]=C(/N)NCC(C)(C)N1CCOCC1,-1.1193999999999962
73595,Optimize the molecule Cc1cccc(C)c1-n1nnnc1S[C@@H](C)C(=O)Nc1nc(C)c(C)s1 to have a lower LogP value.,Cc1cccc(C)c1-n1nnnc1S[C@@H](C)C(=O)Nc1nc(C)c(C)s1,3.4717800000000016
86916,Please modify the molecule CSc1nc(Cl)cc(NCC2CCN(C(=O)OC(C)(C)C)CC2)n1 to increase its LogP value.,CSc1nc(Cl)cc(NCC2CCN(C(=O)OC(C)(C)C)CC2)n1,3.9109000000000025
98047,Modify the molecule Cc1ccc(CN(CC[NH+](C)C)C(=O)Nc2ccc3c(c2)C(=O)NC3=O)o1 to have a higher LogP value.,Cc1ccc(CN(CC[NH+](C)C)C(=O)Nc2ccc3c(c2)C(=O)NC3=O)o1,0.6502199999999999
128951,Please optimize the molecule CCOc1cc(C(=O)Nc2ccccc2N2CCOCC2)ccc1OC to have a higher LogP value.,CCOc1cc(C(=O)Nc2ccccc2N2CCOCC2)ccc1OC,3.182800000000002
70616,Modify the molecule COc1cc(C(=S)NC[C@@H]2CCCO2)ccc1O to decrease its LogP value.,COc1cc(C(=S)NC[C@@H]2CCCO2)ccc1O,1.8448999999999995
217862,Optimize the molecule C[NH2+]CCSCc1ccccc1 to have a higher LogP value.,C[NH2+]CCSCc1ccccc1,1.113
175681,Modify the molecule CC1=NC(c2ccc(C[NH+](C)CC3CC[NH+](C)CC3)cc2)=NC(=O)[C@@H]1C to decrease its LogP value.,CC1=NC(c2ccc(C[NH+](C)CC3CC[NH+](C)CC3)cc2)=NC(=O)[C@@H]1C,0.009800000000004028
136733,Please modify the molecule CC[C@@H]1CN(Cc2cn(C)nc2-c2ccc([N+](=O)[O-])cc2)CCN1CC(F)F to increase its LogP value.,CC[C@@H]1CN(Cc2cn(C)nc2-c2ccc([N+](=O)[O-])cc2)CCN1CC(F)F,3.156600000000002
39366,Optimize the molecule O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1Cl to have a higher LogP value.,O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1Cl,2.725900000000001
11420,Please optimize the molecule CC(C)(CNC(=O)c1cccc(C[NH+]2CCCC2)c1)NS(C)(=O)=O to have a lower LogP value.,CC(C)(CNC(=O)c1cccc(C[NH+]2CCCC2)c1)NS(C)(=O)=O,-0.07709999999999723
237356,Optimize the molecule Cc1nc(C[C@@H]2CCC[NH+](Cc3ccn(Cc4ccccc4)c3)C2)no1 to have a lower LogP value.,Cc1nc(C[C@@H]2CCC[NH+](Cc3ccn(Cc4ccccc4)c3)C2)no1,2.2654199999999998
90475,Modify the molecule COc1ccccc1-n1c(SCC(=O)N2CCCC[C@H]2C)nc2sc3c(c2c1=O)CCCC3 to increase its LogP value.,COc1ccccc1-n1c(SCC(=O)N2CCCC[C@H]2C)nc2sc3c(c2c1=O)CCCC3,4.827700000000005
80787,Optimize the molecule CCCCC[C@H](C)n1c([C@@H](C)Cl)nc2c(C)ccnc21 to have a lower LogP value.,CCCCC[C@H](C)n1c([C@@H](C)Cl)nc2c(C)ccnc21,5.180820000000005
98921,Modify the molecule CCc1ccc(C(=O)Nc2ccc(CC(=O)N3CC[NH+](CC)CC3)cc2)o1 to decrease its LogP value.,CCc1ccc(C(=O)Nc2ccc(CC(=O)N3CC[NH+](CC)CC3)cc2)o1,1.3838000000000006
204474,Optimize the molecule CC1(C)C(C(=O)N2C[C@@H]3C[NH2+]C[C@@H]3C2)C1(C)C to have a higher LogP value.,CC1(C)C(C(=O)N2C[C@@H]3C[NH2+]C[C@@H]3C2)C1(C)C,0.3202000000000007
159437,Modify the molecule Cc1nnc(NC(=O)c2ccccc2OCc2ccc(Cl)cc2)o1 to have a lower LogP value.,Cc1nnc(NC(=O)c2ccccc2OCc2ccc(Cl)cc2)o1,3.862720000000002
59691,Please optimize the molecule CN(Cc1cccc(-n2cccn2)c1)C(=O)c1cc(=O)n(-c2ccccc2)[nH]1 to have a higher LogP value.,CN(Cc1cccc(-n2cccn2)c1)C(=O)c1cc(=O)n(-c2ccccc2)[nH]1,2.6235
242561,Modify the molecule O=C(NCCCCn1cnnc1)c1c(F)cccc1F to have a higher LogP value.,O=C(NCCCCn1cnnc1)c1c(F)cccc1F,1.7665
147538,Modify the molecule COc1ccc(OC)c(S(=O)(=O)N2CCN=C2c2ccccc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)N2CCN=C2c2ccccc2)c1,2.1549000000000005
137298,Modify the molecule CCc1ccc(NC(=S)N2CCOCC2)cc1 to decrease its LogP value.,CCc1ccc(NC(=S)N2CCOCC2)cc1,2.2780000000000005
52882,Please optimize the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)C3=Cc4ccccc4OC3)C2)c1 to have a higher LogP value.,COc1cc(OC)cc([C@H]2CCN(C(=O)C3=Cc4ccccc4OC3)C2)c1,3.495700000000002
120204,Please modify the molecule CNc1nc2ccccc2cc1CSC[C@@H](O)CO to increase its LogP value.,CNc1nc2ccccc2cc1CSC[C@@H](O)CO,1.8628999999999993
217895,Modify the molecule CCC[C@@H]1C[C@@]1(O)[C@@H]1CCOC1 to increase its LogP value.,CCC[C@@H]1C[C@@]1(O)[C@@H]1CCOC1,1.574
59755,Please optimize the molecule CCC[C@@H](Cc1ccc2nccnc2n1)[NH2+]CC to have a higher LogP value.,CCC[C@@H](Cc1ccc2nccnc2n1)[NH2+]CC,1.3193000000000001
117653,Optimize the molecule O=C([O-])[C@H](Cc1cccc(F)c1)CC1CC1 to have a higher LogP value.,O=C([O-])[C@H](Cc1cccc(F)c1)CC1CC1,1.5343999999999993
240024,Please modify the molecule C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)Nc1nc(C#N)c(C#N)[n-]1 to increase its LogP value.,C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)Nc1nc(C#N)c(C#N)[n-]1,2.8551599999999997
151382,Please optimize the molecule Cn1ncnc1CCNC(=O)CCn1c([S-])nnc1-c1cccs1 to have a lower LogP value.,Cn1ncnc1CCNC(=O)CCn1c([S-])nnc1-c1cccs1,0.7898999999999996
75605,Modify the molecule CC(C)C[NH+](CC(C)C)[C@H]1CC[C@@](C#N)(NC2CC2)C1 to have a higher LogP value.,CC(C)C[NH+](CC(C)C)[C@H]1CC[C@@](C#N)(NC2CC2)C1,1.7501799999999994
245942,Modify the molecule Cc1ccc(C[NH2+][C@@H](C)CCN2CCOCC2)nc1 to decrease its LogP value.,Cc1ccc(C[NH2+][C@@H](C)CCN2CCOCC2)nc1,0.564220000000001
241275,Please modify the molecule Cc1cc(C(=O)CCC(=O)N[C@H](C#N)c2ccccc2C)c(C)s1 to decrease its LogP value.,Cc1cc(C(=O)CCC(=O)N[C@H](C#N)c2ccccc2C)c(C)s1,4.0173400000000035
39088,Modify the molecule Cc1ccc(-c2nc3ccccc3c(=O)n2CS(=O)(=O)c2ccccc2)cc1 to have a lower LogP value.,Cc1ccc(-c2nc3ccccc3c(=O)n2CS(=O)(=O)c2ccccc2)cc1,3.803320000000003
143477,Please modify the molecule CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O to decrease its LogP value.,CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O,1.61832
224049,Modify the molecule Cc1cnc(Cl)nc1N[C@@H](C)C(C)C to decrease its LogP value.,Cc1cnc(Cl)nc1N[C@@H](C)C(C)C,2.894820000000001
14197,Modify the molecule OCc1ccc(-c2ccnc(F)c2)cc1 to increase its LogP value.,OCc1ccc(-c2ccnc(F)c2)cc1,2.38
183298,Modify the molecule COc1cccc(OC)c1C(=O)Nc1ccccc1N1CCN(C(=O)c2ccccc2)CC1 to decrease its LogP value.,COc1cccc(OC)c1C(=O)Nc1ccccc1N1CCN(C(=O)c2ccccc2)CC1,3.9185000000000034
181281,Modify the molecule C[C@H]1CCCC[C@H]1[NH2+]C[C@H](C(=O)N1CCOCC1)c1ccccc1 to decrease its LogP value.,C[C@H]1CCCC[C@H]1[NH2+]C[C@H](C(=O)N1CCOCC1)c1ccccc1,1.7711000000000006
1258,Optimize the molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C to have a higher LogP value.,CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C,-0.19549999999999734
24090,Optimize the molecule CCOC(=O)c1c(C)oc2ncn(C[C@H](O)Cn3c4ccccc4c4ccccc43)c(=O)c12 to have a lower LogP value.,CCOC(=O)c1c(C)oc2ncn(C[C@H](O)Cn3c4ccccc4c4ccccc43)c(=O)c12,3.643620000000002
14568,Modify the molecule CC[C@H]1C[NH2+][C@H](Cc2ccccc2)CN1c1ccn(C)n1 to have a lower LogP value.,CC[C@H]1C[NH2+][C@H](Cc2ccccc2)CN1c1ccn(C)n1,1.1933999999999994
140750,Please optimize the molecule CCN(CC1CC1)C(=O)c1cc2c(C)cc(C)cc2[nH]1 to have a lower LogP value.,CCN(CC1CC1)C(=O)c1cc2c(C)cc(C)cc2[nH]1,3.6568400000000025
155853,Please optimize the molecule COc1ccc([C@@H](NC(=O)[C@H](C)n2cncn2)C2CCOCC2)cc1 to have a lower LogP value.,COc1ccc([C@@H](NC(=O)[C@H](C)n2cncn2)C2CCOCC2)cc1,2.1318
174915,Please optimize the molecule Cc1cccc2c1N(C(=O)c1ccc(S(=O)(=O)N3C[C@@H](C)O[C@H](C)C3)cc1)CCC2 to have a higher LogP value.,Cc1cccc2c1N(C(=O)c1ccc(S(=O)(=O)N3C[C@@H](C)O[C@H](C)C3)cc1)CCC2,3.3859200000000023
8712,Please optimize the molecule Cc1ccccc1N1CCN(CC(=O)Nc2cccc(Cl)c2Cl)CC1 to have a lower LogP value.,Cc1ccccc1N1CCN(CC(=O)Nc2cccc(Cl)c2Cl)CC1,4.062520000000003
116784,Modify the molecule C[C@]12CCC(=O)N1[C@H](C(=O)N1CCC[C@@H]1C(=O)[O-])CS2 to have a lower LogP value.,C[C@]12CCC(=O)N1[C@H](C(=O)N1CCC[C@@H]1C(=O)[O-])CS2,-0.8186999999999993
73694,Please optimize the molecule Cc1cc(C)n(C[C@@H](C)CNC(=O)C(=O)Nc2ccc3nc(C)oc3c2)n1 to have a higher LogP value.,Cc1cc(C)n(C[C@@H](C)CNC(=O)C(=O)Nc2ccc3nc(C)oc3c2)n1,2.34056
234776,Please optimize the molecule CSc1ccc(-c2nccn2CCS(=O)(=O)CC(C)C)cc1 to have a higher LogP value.,CSc1ccc(-c2nccn2CCS(=O)(=O)CC(C)C)cc1,3.3428000000000013
133707,Modify the molecule CC[NH2+][C@@H](Cc1cccc(C)c1)C1([NH+](C)C)CCCCC1 to increase its LogP value.,CC[NH2+][C@@H](Cc1cccc(C)c1)C1([NH+](C)C)CCCCC1,1.33682
188087,Optimize the molecule C=CCOc1ccc([C@@H]2NC(=O)c3ccccc3N2C)cc1 to have a lower LogP value.,C=CCOc1ccc([C@@H]2NC(=O)c3ccccc3N2C)cc1,3.129800000000002
233420,Please modify the molecule CCc1nc(Oc2cccc(F)c2)c2oc3ccccc3c2n1 to decrease its LogP value.,CCc1nc(Oc2cccc(F)c2)c2oc3ccccc3c2n1,4.869800000000003
104992,Please modify the molecule CC(C)(C)SC[C@H]([NH3+])[C@@H]1CCc2cccnc21 to increase its LogP value.,CC(C)(C)SC[C@H]([NH3+])[C@@H]1CCc2cccnc21,2.2536000000000005
109442,Modify the molecule COc1ccc(OCC(=O)N[C@@H](C)c2ccc(F)c(F)c2)cc1 to increase its LogP value.,COc1ccc(OCC(=O)N[C@@H](C)c2ccc(F)c(F)c2)cc1,3.2296000000000022
44995,Modify the molecule CC(=O)N1CCOc2ccc(S(=O)(=O)NCc3ccc4c(c3)OCO4)cc21 to have a higher LogP value.,CC(=O)N1CCOc2ccc(S(=O)(=O)NCc3ccc4c(c3)OCO4)cc21,1.6390999999999996
44554,Optimize the molecule COCCCN1C(=O)c2ccc(-c3ccco3)n2C[C@@]1(C)C(=O)N[C@@H]1CCCC[C@H]1C to have a lower LogP value.,COCCCN1C(=O)c2ccc(-c3ccco3)n2C[C@@]1(C)C(=O)N[C@@H]1CCCC[C@H]1C,3.6940000000000026
122813,Optimize the molecule CCc1ccc(S(=O)(=O)Oc2ccc(C#N)cc2[N+](=O)[O-])s1 to have a lower LogP value.,CCc1ccc(S(=O)(=O)Oc2ccc(C#N)cc2[N+](=O)[O-])s1,2.858080000000001
85636,Optimize the molecule COc1ccc(OC)c(CN2CCCn3cccc3[C@H]2c2ccccc2C)c1 to have a lower LogP value.,COc1ccc(OC)c(CN2CCCn3cccc3[C@H]2c2ccccc2C)c1,4.809020000000005
138066,Modify the molecule Cc1ccc(-n2ncc(C(=O)O[C@H](C)[C@H]3CCOC3)c2C(F)(F)F)cc1 to decrease its LogP value.,Cc1ccc(-n2ncc(C(=O)O[C@H](C)[C@H]3CCOC3)c2C(F)(F)F)cc1,3.7813200000000027
169524,Modify the molecule COC(=O)C1=C([O-])N=C(SCC(=O)Nc2ccc3ccccc3c2)[C@@H](C#N)[C@@H]1c1ccc(C)cc1 to have a higher LogP value.,COC(=O)C1=C([O-])N=C(SCC(=O)Nc2ccc3ccccc3c2)[C@@H](C#N)[C@@H]1c1ccc(C)cc1,3.9005000000000027
224559,Modify the molecule Cc1ccc(-c2ncco2)cc1NC(=O)NCCC(=O)OC(C)C to increase its LogP value.,Cc1ccc(-c2ncco2)cc1NC(=O)NCCC(=O)OC(C)C,3.113220000000002
221069,Modify the molecule COc1ccc([C@H]([NH2+]C[C@H](C)SC)C2CC2)cc1 to have a higher LogP value.,COc1ccc([C@H]([NH2+]C[C@H](C)SC)C2CC2)cc1,2.4612000000000007
26852,Please modify the molecule CCOC(=O)C[NH2+]C[C@@H]1CSc2ccccc21 to decrease its LogP value.,CCOC(=O)C[NH2+]C[C@@H]1CSc2ccccc21,1.0023999999999993
40460,Optimize the molecule COc1cc(Br)c(/C=C(\C#N)C(=O)Nc2cccc(Cl)c2C)cc1OC to have a higher LogP value.,COc1cc(Br)c(/C=C(\C#N)C(=O)Nc2cccc(Cl)c2C)cc1OC,4.973800000000002
10549,Modify the molecule Cn1cnn(-c2ccc(NC(=O)[C@@H]3COc4ccccc4O3)cc2)c1=O to have a higher LogP value.,Cn1cnn(-c2ccc(NC(=O)[C@@H]3COc4ccccc4O3)cc2)c1=O,1.3494999999999995
163774,Optimize the molecule O=C1C=C/C(=N\c2ccc3c(c2)Cc2cc(Br)ccc2-3)O1 to have a lower LogP value.,O=C1C=C/C(=N\c2ccc3c(c2)Cc2cc(Br)ccc2-3)O1,4.163300000000002
220676,Please modify the molecule COc1ccc(C(=O)C(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1 to decrease its LogP value.,COc1ccc(C(=O)C(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1,2.3575
145692,Optimize the molecule Nc1nccnc1C(=O)NCc1ccccc1CN1CCN(c2ccccc2)CC1 to have a higher LogP value.,Nc1nccnc1C(=O)NCc1ccccc1CN1CCN(c2ccccc2)CC1,2.311
113994,Modify the molecule C/C(=N/O)c1cc(F)ccc1OCc1c(Cl)cccc1Cl to have a lower LogP value.,C/C(=N/O)c1cc(F)ccc1OCc1c(Cl)cccc1Cl,4.909700000000003
135060,Optimize the molecule C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1 to have a higher LogP value.,C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1,2.844100000000001
219936,Modify the molecule COc1ccc(Nc2nc(C(=O)NC3CCCC3)cs2)cc1 to have a lower LogP value.,COc1ccc(Nc2nc(C(=O)NC3CCCC3)cs2)cc1,3.567700000000002
13845,Please optimize the molecule C[C@@H]1C[C@@H]1C(=O)Nc1cccc(F)c1I to have a lower LogP value.,C[C@@H]1C[C@@H]1C(=O)Nc1cccc(F)c1I,3.024800000000001
248572,Optimize the molecule CC[NH2+][C@H]1CCCC[C@@H](C[C@@H]2CSc3ccccc32)C1 to have a higher LogP value.,CC[NH2+][C@H]1CCCC[C@@H](C[C@@H]2CSc3ccccc32)C1,3.798200000000003
146461,Modify the molecule CC(C)(C)[C@@H](C#N)NC(=O)c1ccc2c(c1)COCO2 to have a lower LogP value.,CC(C)(C)[C@@H](C#N)NC(=O)c1ccc2c(c1)COCO2,2.2211800000000004
194972,Please modify the molecule CSc1ccc(C(=O)Nc2ccc3c(c2)CCCN3C(C)=O)cn1 to increase its LogP value.,CSc1ccc(C(=O)Nc2ccc3c(c2)CCCN3C(C)=O)cn1,3.3549000000000015
4382,Optimize the molecule COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@H]4[C@@H]5C=C[C@@H](C5)[C@@H]4C3=O)cc2)nc(OC)n1 to have a lower LogP value.,COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@H]4[C@@H]5C=C[C@@H](C5)[C@@H]4C3=O)cc2)nc(OC)n1,1.6060999999999999
195546,Modify the molecule [NH3+]C1(C(=O)N2CCC3(CCC(=O)N(CCc4ccncc4)C3)CC2)CC1 to decrease its LogP value.,[NH3+]C1(C(=O)N2CCC3(CCC(=O)N(CCc4ccncc4)C3)CC2)CC1,0.6297999999999999
224193,Optimize the molecule CCc1nn2c(nnc3c(=O)n(Cc4cccnc4)ccc32)c1-c1ccc(F)cc1 to have a higher LogP value.,CCc1nn2c(nnc3c(=O)n(Cc4cccnc4)ccc32)c1-c1ccc(F)cc1,3.2510000000000012
143435,Please optimize the molecule CCOc1ccccc1CNC(=O)[C@H]1C[C@H]2CC[C@@H]1O2 to have a higher LogP value.,CCOc1ccccc1CNC(=O)[C@H]1C[C@H]2CC[C@@H]1O2,2.269
178074,Modify the molecule CC(C)c1csc(CNC(=O)NCC2(c3ccc(F)cc3F)CC2)n1 to have a higher LogP value.,CC(C)c1csc(CNC(=O)NCC2(c3ccc(F)cc3F)CC2)n1,4.075700000000002
75116,Modify the molecule Cc1ccc(NC(=O)NCCC(C)C)c(OCC(=O)N(C)C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)NCCC(C)C)c(OCC(=O)N(C)C)c1,2.629620000000001
61462,Modify the molecule CC(C)C[NH2+]C[C@@]1(S(C)(=O)=O)CCC[C@H]1C to increase its LogP value.,CC(C)C[NH2+]C[C@@]1(S(C)(=O)=O)CCC[C@H]1C,0.8092000000000006
75857,Modify the molecule CC[C@@H](CCO)CNc1nccn(C(C)C)c1=O to have a lower LogP value.,CC[C@@H](CCO)CNc1nccn(C(C)C)c1=O,1.6446999999999998
7226,Optimize the molecule CCN(CC(=O)OC)C(=O)C1[C@H]2CCCC[C@@H]12 to have a higher LogP value.,CCN(CC(=O)OC)C(=O)C1[C@H]2CCCC[C@@H]12,1.4440999999999995
193989,Modify the molecule C[C@H](C(=O)N1CCCCC1)[NH+]1CCN(CCC[NH3+])CC1 to have a lower LogP value.,C[C@H](C(=O)N1CCCCC1)[NH+]1CCN(CCC[NH3+])CC1,-1.7800999999999951
225248,Please modify the molecule CCOC(=O)c1c(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)sc2c1CCN(C(C)=O)C2 to decrease its LogP value.,CCOC(=O)c1c(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)sc2c1CCN(C(C)=O)C2,5.296900000000004
104946,Modify the molecule CCNC(=O)c1ccc(NC(=O)N2CCC[C@H]2c2ccccc2OC)cc1 to increase its LogP value.,CCNC(=O)c1ccc(NC(=O)N2CCC[C@H]2c2ccccc2OC)cc1,3.813900000000003
107879,Optimize the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)N(C)[C@@H](C)c1ccco1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)N(C)[C@@H](C)c1ccco1,3.270900000000002
117305,Modify the molecule C[C@@H](Sc1nnnn1C[C@@H]1CCCO1)C(=O)N1c2ccccc2NC(=O)C1(C)C to decrease its LogP value.,C[C@@H](Sc1nnnn1C[C@@H]1CCCO1)C(=O)N1c2ccccc2NC(=O)C1(C)C,2.0965999999999996
141579,Please modify the molecule CSc1ccc([N+](=O)[O-])c(C(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c1 to decrease its LogP value.,CSc1ccc([N+](=O)[O-])c(C(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c1,2.860000000000002
223531,Modify the molecule C[C@H](NC(=O)c1ccc(S(=O)(=O)NC2CC2)cc1)c1ccccc1Br to increase its LogP value.,C[C@H](NC(=O)c1ccc(S(=O)(=O)NC2CC2)cc1)c1ccccc1Br,3.3808000000000025
76677,Modify the molecule CN(CC(=O)N[C@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C to have a higher LogP value.,CN(CC(=O)N[C@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C,1.051499999999999
161591,Please optimize the molecule Cc1ccc(CC(=O)N2CCC[NH+](Cc3ccc(F)cc3)CC2)cc1 to have a higher LogP value.,Cc1ccc(CC(=O)N2CCC[NH+](Cc3ccc(F)cc3)CC2)cc1,1.9940199999999997
122166,Modify the molecule O=C(NCc1csc(Br)c1)NCc1ccco1 to have a higher LogP value.,O=C(NCc1csc(Br)c1)NCc1ccco1,3.1030000000000015
138445,Modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@H]([NH+](C)C2CC2)C1 to have a lower LogP value.,C[NH2+][C@]1(C(=O)[O-])CCC[C@H]([NH+](C)C2CC2)C1,-2.711999999999996
92904,Modify the molecule COc1ccc(NC(=O)NC[C@@H](O)c2ccc(Cl)cc2)c(C)c1 to have a lower LogP value.,COc1ccc(NC(=O)NC[C@@H](O)c2ccc(Cl)cc2)c(C)c1,3.5121200000000012
41554,Please optimize the molecule Cc1ncccc1NC(=O)C(=O)NC[C@@H]1CCCc2ccccc21 to have a lower LogP value.,Cc1ncccc1NC(=O)C(=O)NC[C@@H]1CCCc2ccccc21,2.56482
188468,Modify the molecule c1ccc(C[C@H]2C[NH+]3CCC[C@H]3CN2Cc2cncn2Cc2ccccc2)cc1 to increase its LogP value.,c1ccc(C[C@H]2C[NH+]3CCC[C@H]3CN2Cc2cncn2Cc2ccccc2)cc1,2.4056000000000006
124635,Modify the molecule O=[N+]([O-])c1cccc(CCN[C@@H]2CC[NH+](C3CC3)C2)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(CCN[C@@H]2CC[NH+](C3CC3)C2)c1,0.5465000000000004
219777,Please optimize the molecule CCOc1ccc(NC(=O)NCc2ccccc2Cn2cccn2)cc1F to have a lower LogP value.,CCOc1ccc(NC(=O)NCc2ccccc2Cn2cccn2)cc1F,3.7909000000000024
88347,Modify the molecule C=C(Cl)Cc1ccccn1 to have a higher LogP value.,C=C(Cl)Cc1ccccn1,2.3766
124701,Please optimize the molecule COC[C@@H](NC(=O)C[C@@H](O)c1cc(Cl)cc(Cl)c1)c1ccccc1 to have a lower LogP value.,COC[C@@H](NC(=O)C[C@@H](O)c1cc(Cl)cc(Cl)c1)c1ccccc1,3.9208000000000025
27335,Modify the molecule CN(C1CCC(C)(C)CC1)S(=O)(=O)c1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,CN(C1CCC(C)(C)CC1)S(=O)(=O)c1ccc(S(N)(=O)=O)cc1,1.9232999999999998
126920,Optimize the molecule CCOCc1ccc(NC(=O)C(=O)N(C)Cc2ccc(C#N)cc2)cc1 to have a higher LogP value.,CCOCc1ccc(NC(=O)C(=O)N(C)Cc2ccc(C#N)cc2)cc1,2.691880000000001
47407,Modify the molecule CS(=O)(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1 to have a lower LogP value.,CS(=O)(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1,0.7242
120047,Please modify the molecule CCc1nnc([O-])c(C(=O)N[C@@H](C)c2nc3ccccc3[nH]2)c1CC to decrease its LogP value.,CCc1nnc([O-])c(C(=O)N[C@@H](C)c2nc3ccccc3[nH]2)c1CC,2.0423
151391,Modify the molecule O=C(NCc1cccs1)c1cccc(S(=O)(=O)N2CCCC2)c1 to have a higher LogP value.,O=C(NCc1cccs1)c1cccc(S(=O)(=O)N2CCCC2)c1,2.462600000000001
95642,Please optimize the molecule COc1cc(OC)cc(-c2cc3nc(C)c(CCC(=O)[O-])c(C)n3n2)c1 to have a higher LogP value.,COc1cc(OC)cc(-c2cc3nc(C)c(CCC(=O)[O-])c(C)n3n2)c1,1.7128399999999997
186235,Please modify the molecule O=C1NCC=Cc2c1[nH]c(Br)c2Br to decrease its LogP value.,O=C1NCC=Cc2c1[nH]c(Br)c2Br,2.2963
123143,Please modify the molecule Cn1c(=O)c2c(-c3ccc(Cl)cc3)n(CC(=O)[O-])cc2n(C)c1=O to decrease its LogP value.,Cn1c(=O)c2c(-c3ccc(Cl)cc3)n(CC(=O)[O-])cc2n(C)c1=O,0.10899999999999954
248167,Modify the molecule Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1 to have a higher LogP value.,Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1,4.0605100000000025
25254,Modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N[C@H]2CCS(=O)(=O)C2)cc1 to have a lower LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N[C@H]2CCS(=O)(=O)C2)cc1,2.01104
203240,Optimize the molecule Cc1ccc(S(=O)(=O)N2CCN(CC(=O)Nc3ccc(C)c(C)c3)CC2)c(C)c1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)N2CCN(CC(=O)Nc3ccc(C)c(C)c3)CC2)c(C)c1,2.865280000000002
204142,Modify the molecule CC(C)c1cnc(C[NH+]2CCN(CCN3C(=O)CCC3=O)CC2)o1 to decrease its LogP value.,CC(C)c1cnc(C[NH+]2CCN(CCN3C(=O)CCC3=O)CC2)o1,-0.3524999999999969
228449,Please optimize the molecule COc1ccc(OC)c(NC(=O)c2cc(-c3ccc(F)cc3)oc2C)c1 to have a lower LogP value.,COc1ccc(OC)c(NC(=O)c2cc(-c3ccc(F)cc3)oc2C)c1,4.663620000000003
166027,Modify the molecule CSCc1ccnc(N2CCO[C@H](c3ccc(C)cc3C)C2)c1 to have a lower LogP value.,CSCc1ccnc(N2CCO[C@H](c3ccc(C)cc3C)C2)c1,4.139340000000003
245011,Optimize the molecule O=C(Nc1ccc(I)cc1)c1cccc(-n2cnnc2)n1 to have a higher LogP value.,O=C(Nc1ccc(I)cc1)c1cccc(-n2cnnc2)n1,2.5191999999999997
218107,Please optimize the molecule CSCc1nnc(NC(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)o1 to have a lower LogP value.,CSCc1nnc(NC(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)o1,2.749600000000001
211087,Modify the molecule Cc1nc(Nc2ncnc(Nc3ccc4c(c3)OCO4)c2[N+](=O)[O-])sc1C to have a higher LogP value.,Cc1nc(Nc2ncnc(Nc3ccc4c(c3)OCO4)c2[N+](=O)[O-])sc1C,3.6740400000000015
93623,Please optimize the molecule C[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(Cl)cc1 to have a higher LogP value.,C[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(Cl)cc1,3.2989000000000015
197892,Optimize the molecule COc1cccc([C@@H]2CN(C(=O)c3cnn(C)c3)C[C@H]2C(=O)[O-])c1OC to have a lower LogP value.,COc1cccc([C@@H]2CN(C(=O)c3cnn(C)c3)C[C@H]2C(=O)[O-])c1OC,0.043000000000000815
40752,Modify the molecule COc1ccccc1N1CCN(C(=O)c2cccc(S(=O)(=O)N3c4ccccc4C[C@H]3C)c2)CC1 to decrease its LogP value.,COc1ccccc1N1CCN(C(=O)c2cccc(S(=O)(=O)N3c4ccccc4C[C@H]3C)c2)CC1,3.797500000000003
53459,Modify the molecule Cc1cnn(-c2ccccc2)c1NC(=O)[C@H]1COc2ccc(F)cc2C1 to have a lower LogP value.,Cc1cnn(-c2ccccc2)c1NC(=O)[C@H]1COc2ccc(F)cc2C1,3.5096200000000017
93590,Please optimize the molecule Cc1nc2n(n1)C[C@H]([NH2+][C@@H](C)C(=O)Nc1cc(C)on1)CC2 to have a higher LogP value.,Cc1nc2n(n1)C[C@H]([NH2+][C@@H](C)C(=O)Nc1cc(C)on1)CC2,-0.2116599999999993
117525,Modify the molecule COc1cc(C)ccc1NCC(=O)Nc1ccc(F)c(F)c1 to increase its LogP value.,COc1cc(C)ccc1NCC(=O)Nc1ccc(F)c(F)c1,3.332420000000001
143590,Optimize the molecule COc1cccc(OC)c1C(=O)N1CCN(C(=O)c2cc3cc(C)ccc3n2C)CC1 to have a lower LogP value.,COc1cccc(OC)c1C(=O)N1CCN(C(=O)c2cc3cc(C)ccc3n2C)CC1,3.102120000000002
118541,Please modify the molecule CCc1ccc([C@@H](C)NC(=O)[C@@H](C)Sc2nnc(C)c(=O)n2N)cc1 to decrease its LogP value.,CCc1ccc([C@@H](C)NC(=O)[C@@H](C)Sc2nnc(C)c(=O)n2N)cc1,1.5809199999999997
240814,Optimize the molecule C[C@@H]1c2ccc(O)cc2OC(=O)[C@@H]1CC(=O)NC1=CC2=CC=N[C@@H]2C=C1 to have a lower LogP value.,C[C@@H]1c2ccc(O)cc2OC(=O)[C@@H]1CC(=O)NC1=CC2=CC=N[C@@H]2C=C1,2.3703000000000003
14849,Please modify the molecule COC(=O)[C@@H]1CN(C(=O)Nc2cncc3ccccc23)C[C@H]1C to increase its LogP value.,COC(=O)[C@@H]1CN(C(=O)Nc2cncc3ccccc23)C[C@H]1C,2.507600000000001
99809,Please optimize the molecule C[C@@H](CCO)CNc1ncnc2ccc(F)cc12 to have a higher LogP value.,C[C@@H](CCO)CNc1ncnc2ccc(F)cc12,2.1993
205795,Please modify the molecule C[C@]1(C(=O)N2CCC(CC(=O)[O-])CC2)CCC[NH2+]C1 to increase its LogP value.,C[C@]1(C(=O)N2CCC(CC(=O)[O-])CC2)CCC[NH2+]C1,-1.2714999999999967
226300,Please modify the molecule C[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C to increase its LogP value.,C[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C,1.8218
174788,Modify the molecule CC(C)n1cc(S(=O)(=O)N[C@@H](CC(F)(F)F)c2ccc(F)cc2)cn1 to have a lower LogP value.,CC(C)n1cc(S(=O)(=O)N[C@@H](CC(F)(F)F)c2ccc(F)cc2)cn1,3.5751000000000017
130915,Optimize the molecule O=C(CCN1C(=O)/C(=C/c2ccccc2O)SC1=S)Nc1ccc(Cl)cc1 to have a lower LogP value.,O=C(CCN1C(=O)/C(=C/c2ccccc2O)SC1=S)Nc1ccc(Cl)cc1,4.2756000000000025
248004,Modify the molecule CCC[C@@H]1C[C@@H](Nc2cc(OC)ccc2F)CCO1 to have a lower LogP value.,CCC[C@@H]1C[C@@H](Nc2cc(OC)ccc2F)CCO1,3.5939000000000023
194032,Optimize the molecule O=S(=O)(NCc1ccccc1)c1ccc(-c2cnc(C3CC3)o2)s1 to have a higher LogP value.,O=S(=O)(NCc1ccccc1)c1ccc(-c2cnc(C3CC3)o2)s1,3.759000000000003
212242,Modify the molecule CCCN1C(=O)CCc2cc(NC(=O)NC[C@H](O)c3cnn(C)c3)ccc21 to have a lower LogP value.,CCCN1C(=O)CCc2cc(NC(=O)NC[C@H](O)c3cnn(C)c3)ccc21,1.964399999999999
171261,Please optimize the molecule CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1 to have a higher LogP value.,CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1,1.0074000000000007
57961,Modify the molecule C[NH2+][C@H](Cc1ccccc1Br)C(C)(C)N1CCOCC1 to decrease its LogP value.,C[NH2+][C@H](Cc1ccccc1Br)C(C)(C)N1CCOCC1,1.6642000000000001
170183,Optimize the molecule Cc1noc(C(C)C)c1C(=O)NCc1cccnc1 to have a higher LogP value.,Cc1noc(C(C)C)c1C(=O)NCc1cccnc1,2.43142
172534,Modify the molecule COc1ccc(-c2nsc(NC(=O)COc3cccc(C)c3)n2)cc1OC to decrease its LogP value.,COc1ccc(-c2nsc(NC(=O)COc3cccc(C)c3)n2)cc1OC,3.5482200000000015
81353,Optimize the molecule O=C([O-])CNC(=O)c1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1 to have a lower LogP value.,O=C([O-])CNC(=O)c1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1,0.09390000000000098
58697,Please modify the molecule CCCCNC(=O)[C@H]1CCCN(C(=O)c2ccc(NC(C)=O)cc2)C1 to decrease its LogP value.,CCCCNC(=O)[C@H]1CCCN(C(=O)c2ccc(NC(C)=O)cc2)C1,2.4135
138885,Modify the molecule CCNc1nc(N(CC)n2cnnc2)nc(NC(C)(C)C)[nH+]1 to increase its LogP value.,CCNc1nc(N(CC)n2cnnc2)nc(NC(C)(C)C)[nH+]1,0.8139999999999996
95359,Please modify the molecule COc1cc(C(=O)/C=C/c2ccc([N+](=O)[O-])cc2)ccc1OC(F)F to increase its LogP value.,COc1cc(C(=O)/C=C/c2ccc([N+](=O)[O-])cc2)ccc1OC(F)F,4.100900000000002
33815,Please optimize the molecule CCCNC(=O)C(=O)NC[C@H]1OCCCN1S(=O)(=O)c1ccc(F)cc1C to have a higher LogP value.,CCCNC(=O)C(=O)NC[C@H]1OCCCN1S(=O)(=O)c1ccc(F)cc1C,0.5136200000000011
221936,Modify the molecule Cc1cccc(C)c1OCC(=O)Nc1sccc1C#N to decrease its LogP value.,Cc1cccc(C)c1OCC(=O)Nc1sccc1C#N,3.2541200000000012
89459,Modify the molecule CC(C)[C@@H](NC(=O)Nc1ccc([S@@](C)=O)cc1)c1ccccc1 to increase its LogP value.,CC(C)[C@@H](NC(=O)Nc1ccc([S@@](C)=O)cc1)c1ccccc1,3.942800000000002
234000,Please optimize the molecule CCCCN1C[C@@H](C(=O)Nc2ccc(C(=O)NCC)cc2)CC1=O to have a lower LogP value.,CCCCN1C[C@@H](C(=O)Nc2ccc(C(=O)NCC)cc2)CC1=O,2.0233999999999996
57681,Modify the molecule Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-] to have a lower LogP value.,Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-],3.7440000000000015
229979,Please modify the molecule Cc1nn(CC(=O)OC[C@@H]2CN(CC(C)C)CCO2)c(=O)c2ccccc12 to increase its LogP value.,Cc1nn(CC(=O)OC[C@@H]2CN(CC(C)C)CCO2)c(=O)c2ccccc12,1.6049200000000001
176458,Modify the molecule Cc1nn(-c2nc3c(c(=O)n(Cc4ccc(Cl)c(Cl)c4)c(=O)n3C)n2C)c(C)c1C to decrease its LogP value.,Cc1nn(-c2nc3c(c(=O)n(Cc4ccc(Cl)c(Cl)c4)c(=O)n3C)n2C)c(C)c1C,2.8997600000000014
153671,Optimize the molecule Fc1ccc([C@@H](C[NH2+]Cc2ccsc2)N2CCOCC2)cc1 to have a higher LogP value.,Fc1ccc([C@@H](C[NH2+]Cc2ccsc2)N2CCOCC2)cc1,2.0241
86027,Please optimize the molecule COc1ccc(-c2cc(-c3ccccc3)[nH]c(=O)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2cc(-c3ccccc3)[nH]c(=O)n2)cc1OC,3.121100000000001
3207,Modify the molecule COCCn1c2ccccc2n2c(=O)n(CC(=O)N(C)C)nc12 to have a lower LogP value.,COCCn1c2ccccc2n2c(=O)n(CC(=O)N(C)C)nc12,0.18530000000000024
11219,Modify the molecule C[C@@H](CNC(=O)[C@]1(C)CC1(Cl)Cl)c1nc(-c2ccccc2)no1 to have a higher LogP value.,C[C@@H](CNC(=O)[C@]1(C)CC1(Cl)Cl)c1nc(-c2ccccc2)no1,3.5402000000000013
125089,Modify the molecule CCC(=O)N(C)c1ccccc1C(=O)NCc1cccc(C#N)c1 to increase its LogP value.,CCC(=O)N(C)c1ccccc1C(=O)NCc1cccc(C#N)c1,2.861080000000001
45747,Please optimize the molecule Cc1nc(CN(C)[C@H](C[NH3+])c2cccc(C3CC3)c2)cs1 to have a higher LogP value.,Cc1nc(CN(C)[C@H](C[NH3+])c2cccc(C3CC3)c2)cs1,2.743920000000001
33655,Modify the molecule CN[C@@H]1C(=O)Nc2cc(S[C@@H]3CCC[C@@H](C)C3)c(Cl)cc21 to decrease its LogP value.,CN[C@@H]1C(=O)Nc2cc(S[C@@H]3CCC[C@@H](C)C3)c(Cl)cc21,4.223400000000003
164324,Please modify the molecule O=c1cc(NCc2ccc3c(c2)OCCO3)cnn1Cc1ccccc1 to decrease its LogP value.,O=c1cc(NCc2ccc3c(c2)OCCO3)cnn1Cc1ccccc1,2.674900000000001
220845,Optimize the molecule COc1ccc2cc(-c3ccc(C(=O)Nc4ccc5[nH]ccc5c4)cc3)c(=O)oc2c1 to have a higher LogP value.,COc1ccc2cc(-c3ccc(C(=O)Nc4ccc5[nH]ccc5c4)cc3)c(=O)oc2c1,5.202200000000003
204050,Please optimize the molecule O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1 to have a lower LogP value.,O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1,3.7992000000000026
33668,Modify the molecule Cc1cc(C2C[C@@H]3CC[C@H](C2)N3C(=O)c2ccc[nH]c2=O)ccc1F to have a higher LogP value.,Cc1cc(C2C[C@@H]3CC[C@H](C2)N3C(=O)c2ccc[nH]c2=O)ccc1F,3.3732200000000017
6434,Please modify the molecule CNC(=O)NC(=O)Nc1cc(C)ccc1Cl to increase its LogP value.,CNC(=O)NC(=O)Nc1cc(C)ccc1Cl,2.10932
141657,Please optimize the molecule CC(C)(C)Oc1cc(CNC(=O)N2CCC(n3cccn3)CC2)ccn1 to have a higher LogP value.,CC(C)(C)Oc1cc(CNC(=O)N2CCC(n3cccn3)CC2)ccn1,3.0021000000000013
131750,Modify the molecule CCC[NH+]1CCN(C(=O)CN2CC[C@@]3(CCC2=O)NC(=O)c2ccccc2N3)CC1 to have a higher LogP value.,CCC[NH+]1CCN(C(=O)CN2CC[C@@]3(CCC2=O)NC(=O)c2ccccc2N3)CC1,-0.31219999999999515
20326,Please modify the molecule COC(=O)c1cc(-c2ccccc2)nc2nc(NC(C)=O)sc12 to decrease its LogP value.,COC(=O)c1cc(-c2ccccc2)nc2nc(NC(C)=O)sc12,3.103300000000001
186182,Modify the molecule COc1ccc2c(c1)[C@H]([NH3+])[C@@H](Sc1ccc(Cl)cn1)C2 to decrease its LogP value.,COc1ccc2c(c1)[C@H]([NH3+])[C@@H](Sc1ccc(Cl)cn1)C2,2.7436000000000007
34518,Optimize the molecule [NH3+][C@@H]1CCN(C(=O)OCc2ccccc2)C[C@@H]1F to have a higher LogP value.,[NH3+][C@@H]1CCN(C(=O)OCc2ccccc2)C[C@@H]1F,0.9774999999999998
180371,Modify the molecule CC[C@@H](Oc1ccc(/C=C2\SC(=S)N(NC(=O)c3ccccc3O)C2=O)cc1)C(=O)[O-] to have a lower LogP value.,CC[C@@H](Oc1ccc(/C=C2\SC(=S)N(NC(=O)c3ccccc3O)C2=O)cc1)C(=O)[O-],1.8456999999999988
177157,Modify the molecule NC(=O)CC[NH+]1[C@@H](C(=O)[O-])CC[C@@H]2CCCC[C@H]21 to increase its LogP value.,NC(=O)CC[NH+]1[C@@H](C(=O)[O-])CC[C@@H]2CCCC[C@H]21,-1.7821999999999956
69432,Modify the molecule Cn1nc2n(c1=O)-c1ccccc1SC2 to decrease its LogP value.,Cn1nc2n(c1=O)-c1ccccc1SC2,1.1767
227147,Optimize the molecule O=c1[nH]c(=O)n(-c2cccc(Cl)c2)c2c1CN(Cc1cccnc1)CN2 to have a lower LogP value.,O=c1[nH]c(=O)n(-c2cccc(Cl)c2)c2c1CN(Cc1cccnc1)CN2,1.9593999999999996
217234,Please optimize the molecule Cn1cc(C(=O)N2CCOCC2)cc(NC(=O)CCCc2ccccc2)c1=O to have a lower LogP value.,Cn1cc(C(=O)N2CCOCC2)cc(NC(=O)CCCc2ccccc2)c1=O,1.8190999999999995
181863,Please optimize the molecule CCc1c(C)nc2cc(C3CCOCC3)nn2c1NCCC[NH+]1CCCCC1 to have a lower LogP value.,CCc1c(C)nc2cc(C3CCOCC3)nn2c1NCCC[NH+]1CCCCC1,2.3649199999999997
70593,Modify the molecule C=CCO[C@H]1C[C@H]2C[C@@H]1[C@H]1CC=C[C@@H]12 to have a lower LogP value.,C=CCO[C@H]1C[C@H]2C[C@@H]1[C@H]1CC=C[C@@H]12,2.7897000000000007
64681,Optimize the molecule COc1cccc(CC(=O)N2CCC([NH3+])CC2)c1 to have a higher LogP value.,COc1cccc(CC(=O)N2CCC([NH3+])CC2)c1,0.47060000000000046
189699,Modify the molecule Cc1cc(Br)cc(C(=O)[O-])c1Br to decrease its LogP value.,Cc1cc(Br)cc(C(=O)[O-])c1Br,1.8835199999999996
48873,Modify the molecule CCOCC/C([O-])=N/S(=O)(=O)c1ccccc1 to decrease its LogP value.,CCOCC/C([O-])=N/S(=O)(=O)c1ccccc1,0.5606999999999998
1062,Please modify the molecule O=C1C[C@H](c2ccccc2C(F)(F)F)[C@H]2C(=O)N=C(c3ccccc3)N=C2N1 to decrease its LogP value.,O=C1C[C@H](c2ccccc2C(F)(F)F)[C@H]2C(=O)N=C(c3ccccc3)N=C2N1,3.3106000000000018
87991,Please modify the molecule O=c1c2ccccc2c(=O)c2sc3c(=O)c4ccccc4c(=O)c3sc12 to increase its LogP value.,O=c1c2ccccc2c(=O)c2sc3c(=O)c4ccccc4c(=O)c3sc12,3.301000000000001
222927,Optimize the molecule Cc1c(Cl)cccc1NC(=O)c1cc(C2CC2)nc2c1cnn2C(C)C to have a lower LogP value.,Cc1c(Cl)cccc1NC(=O)c1cc(C2CC2)nc2c1cnn2C(C)C,5.103720000000004
109104,Modify the molecule O=C(CNC(=O)Nc1ccn(Cc2ccccc2)n1)NC1CC1 to increase its LogP value.,O=C(CNC(=O)Nc1ccn(Cc2ccccc2)n1)NC1CC1,1.3314999999999997
138084,Optimize the molecule Cc1ncccc1NC(=O)N[C@H](c1ccccc1)C(C)(C)C to have a higher LogP value.,Cc1ncccc1NC(=O)N[C@H](c1ccccc1)C(C)(C)C,4.2989200000000025
50554,Please optimize the molecule CC(C)(C)OC(=O)N1CCC(C(=O)NC2=NCCS2)CC1 to have a higher LogP value.,CC(C)(C)OC(=O)N1CCC(C(=O)NC2=NCCS2)CC1,1.8524999999999998
102211,Please modify the molecule O=C(Cc1ccc2c(c1)CCCC2)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1 to increase its LogP value.,O=C(Cc1ccc2c(c1)CCCC2)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1,3.3374000000000015
32877,Modify the molecule [NH3+]CC1CN([C@H]2CCOC3(CCSCC3)C2)C1 to increase its LogP value.,[NH3+]CC1CN([C@H]2CCOC3(CCSCC3)C2)C1,0.6048999999999998
74500,Modify the molecule Cc1cc2nnc(SCCC(=O)Nc3ccccc3F)n2c(C)n1 to have a higher LogP value.,Cc1cc2nnc(SCCC(=O)Nc3ccccc3F)n2c(C)n1,3.0011400000000013
73940,Optimize the molecule O=C(COc1ccc(Br)cc1F)NCC(=O)Nc1ccc(F)c(F)c1 to have a lower LogP value.,O=C(COc1ccc(Br)cc1F)NCC(=O)Nc1ccc(F)c(F)c1,3.0001000000000007
181345,Modify the molecule O=C(NCCOc1ccc(F)c(F)c1)N[C@@H]1CCc2c(O)cccc21 to increase its LogP value.,O=C(NCCOc1ccc(F)c(F)c1)N[C@@H]1CCc2c(O)cccc21,3.0359000000000016
12208,Modify the molecule CC(C)CC1(CNC(=O)[C@@H](NC(N)=O)C(C)C)CCCC1 to decrease its LogP value.,CC(C)CC1(CNC(=O)[C@@H](NC(N)=O)C(C)C)CCCC1,2.4019999999999992
64377,Optimize the molecule N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1 to have a higher LogP value.,N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1,4.053680000000003
139783,Modify the molecule COc1ccc(NC(=O)CSCC(C)C)cc1 to have a higher LogP value.,COc1ccc(NC(=O)CSCC(C)C)cc1,3.0229000000000017
180698,Modify the molecule Cc1cc2ccccc2n1CC(=O)N1CCN(c2c(N)n(C)c(=O)n(C)c2=O)CC1 to increase its LogP value.,Cc1cc2ccccc2n1CC(=O)N1CCN(c2c(N)n(C)c(=O)n(C)c2=O)CC1,0.27812000000000126
86046,Modify the molecule CC(=O)N[C@H](CC(=O)N[C@H](C)c1ccc(C)o1)c1cccs1 to have a lower LogP value.,CC(=O)N[C@H](CC(=O)N[C@H](C)c1ccc(C)o1)c1cccs1,3.0942200000000017
146205,Please optimize the molecule CC[C@@H](C)NC(=O)c1ccc(NC(=O)N(C2CC2)[C@@H](C)c2ccco2)cc1 to have a lower LogP value.,CC[C@@H](C)NC(=O)c1ccc(NC(=O)N(C2CC2)[C@@H](C)c2ccco2)cc1,4.565400000000004
175151,Please optimize the molecule CC(C)NC(=O)C(=O)NNC(=O)c1cn(-c2ccccc2)nc1-c1ccccc1 to have a higher LogP value.,CC(C)NC(=O)C(=O)NNC(=O)c1cn(-c2ccccc2)nc1-c1ccccc1,1.8249
155666,Please modify the molecule Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1 to decrease its LogP value.,Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1,3.0491600000000014
41650,Optimize the molecule Cc1cc(N2CCC([NH+](C)CCc3ccccc3Cl)CC2)nc(C)[nH+]1 to have a higher LogP value.,Cc1cc(N2CCC([NH+](C)CCc3ccccc3Cl)CC2)nc(C)[nH+]1,1.89214
218117,Optimize the molecule COc1cccc(N2C(=O)c3ccc(C(=O)Nc4ccccc4[N+](=O)[O-])cc3C2=O)c1 to have a higher LogP value.,COc1cccc(N2C(=O)c3ccc(C(=O)Nc4ccccc4[N+](=O)[O-])cc3C2=O)c1,3.6563000000000017
214811,Please modify the molecule Cc1ccc(NCC(=O)N/N=C/c2cc(Cl)ccc2O)cc1 to decrease its LogP value.,Cc1ccc(NCC(=O)N/N=C/c2cc(Cl)ccc2O)cc1,2.916220000000001
22709,Please optimize the molecule CC[NH2+][C@H](Cc1nccn1C)C1CCCC1 to have a higher LogP value.,CC[NH2+][C@H](Cc1nccn1C)C1CCCC1,1.1046999999999998
47716,Modify the molecule O=C(CCc1ccccc1O)NCCCn1cccn1 to decrease its LogP value.,O=C(CCc1ccccc1O)NCCCn1cccn1,1.7278
137979,Please optimize the molecule Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+] to have a higher LogP value.,Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+],2.1434199999999994
5179,Please modify the molecule C=CCOc1ccc(/C=C(\C#N)c2nc([O-])c3ccccc3n2)cc1OC to increase its LogP value.,C=CCOc1ccc(/C=C(\C#N)c2nc([O-])c3ccccc3n2)cc1OC,3.340980000000002
37706,Please optimize the molecule CCCN(Cc1ccccc1O)C(=O)NCc1csc(CC)n1 to have a higher LogP value.,CCCN(Cc1ccccc1O)C(=O)NCc1csc(CC)n1,3.5329000000000015
141038,Please optimize the molecule O=C(N/C=C(\[O-])N1CCc2ccccc21)Nc1cccc(C(F)(F)F)c1 to have a lower LogP value.,O=C(N/C=C(\[O-])N1CCc2ccccc21)Nc1cccc(C(F)(F)F)c1,3.048800000000001
115625,Modify the molecule COc1cc([C@H](C)Nc2nccc(C(F)(F)F)n2)cc(OC)c1OC to increase its LogP value.,COc1cc([C@H](C)Nc2nccc(C(F)(F)F)n2)cc(OC)c1OC,3.694300000000002
17606,Modify the molecule Cc1cc2oc(=O)cc(C[NH+]3CCN(CC(N)=O)CC3)c2cc1C to have a lower LogP value.,Cc1cc2oc(=O)cc(C[NH+]3CCN(CC(N)=O)CC3)c2cc1C,-0.4043599999999983
30118,Please modify the molecule Cc1ccc2nc(COc3ccc(C(=O)N[C@@H](C)c4cccnc4)cc3)cn2c1 to decrease its LogP value.,Cc1ccc2nc(COc3ccc(C(=O)N[C@@H](C)c4cccnc4)cc3)cn2c1,4.107720000000002
133277,Modify the molecule CCc1cccc(S(=O)(=O)N(CC)[C@H](C)c2cccnc2)c1 to decrease its LogP value.,CCc1cccc(S(=O)(=O)N(CC)[C@H](C)c2cccnc2)c1,3.4158000000000026
218502,Optimize the molecule CC[NH+](C)Cc1cc2n(n1)CCN(C(=O)c1cnc3c(c1)ncn3C)C2 to have a higher LogP value.,CC[NH+](C)Cc1cc2n(n1)CCN(C(=O)c1cnc3c(c1)ncn3C)C2,-0.14459999999999873
162593,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)N1c2ccccc2CC[C@@H]1C(C)C to decrease its LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)N1c2ccccc2CC[C@@H]1C(C)C,4.0161200000000035
78430,Please modify the molecule CCOc1ccc(CNC(=O)CS(=O)(=O)NC)cc1C to decrease its LogP value.,CCOc1ccc(CNC(=O)CS(=O)(=O)NC)cc1C,0.5591200000000001
193342,Modify the molecule COc1ccc(OC(=O)c2ccc3c(c2)NC(=O)CCN3C)cc1 to have a higher LogP value.,COc1ccc(OC(=O)c2ccc3c(c2)NC(=O)CCN3C)cc1,2.692800000000001
200148,Please optimize the molecule O=C(Nc1ccc2c(c1)CCC2)C(=O)NC1CC[NH+](C[C@H]2CCOC2)CC1 to have a lower LogP value.,O=C(Nc1ccc2c(c1)CCC2)C(=O)NC1CC[NH+](C[C@H]2CCOC2)CC1,0.31380000000000097
204570,Please optimize the molecule CCc1nn(C)c(OC)c1CNc1c(C#N)c(=O)n(C)c(=O)n1C to have a lower LogP value.,CCc1nn(C)c(OC)c1CNc1c(C#N)c(=O)n(C)c(=O)n1C,-0.1277199999999996
65323,Please optimize the molecule CCCOCC[C@@]1(O)C[C@@H]1C to have a higher LogP value.,CCCOCC[C@@]1(O)C[C@@H]1C,1.5739999999999998
25310,Please modify the molecule COc1ccccc1[C@@H](NC(=O)CCc1ccccc1C)c1noc(C)n1 to decrease its LogP value.,COc1ccccc1[C@@H](NC(=O)CCc1ccccc1C)c1noc(C)n1,3.5334400000000024
235214,Optimize the molecule C[C@H]1CCN(C(=O)c2cc(C#N)cs2)c2cc(Cl)ccc2S1 to have a lower LogP value.,C[C@H]1CCN(C(=O)c2cc(C#N)cs2)c2cc(Cl)ccc2S1,4.804280000000003
71385,Modify the molecule CS[C@H]1CCC[C@@H](NC(=O)CCC(=O)c2ccc(F)c(F)c2)C1 to have a higher LogP value.,CS[C@H]1CCC[C@@H](NC(=O)CCC(=O)c2ccc(F)c(F)c2)C1,3.7181000000000024
97326,Please modify the molecule Cc1c([C@@H]2C[C@@H]2C[NH2+]C(C)C)cnn1C to decrease its LogP value.,Cc1c([C@@H]2C[C@@H]2C[NH2+]C(C)C)cnn1C,0.8038199999999995
153453,Modify the molecule Cc1csc(SCc2cc(=O)oc3cc4c(cc23)CCC4)n1 to decrease its LogP value.,Cc1csc(SCc2cc(=O)oc3cc4c(cc23)CCC4)n1,4.338920000000003
80203,Please modify the molecule C[C@@H]1CN(CCC(=O)c2cc(F)cc(F)c2)CC(C)(C)O1 to increase its LogP value.,C[C@@H]1CN(CCC(=O)c2cc(F)cc(F)c2)CC(C)(C)O1,3.036900000000002
187970,Please modify the molecule C=C(C)CNC(=O)c1noc2c1CCc1ccc(OC)cc1-2 to decrease its LogP value.,C=C(C)CNC(=O)c1noc2c1CCc1ccc(OC)cc1-2,2.7547000000000015
18230,Modify the molecule O=C(CC1CCN(C(=O)N[C@H]2CCC[C@@H](C3CC3)C2)CC1)N1CCCC1 to have a higher LogP value.,O=C(CC1CCN(C(=O)N[C@H]2CCC[C@@H](C3CC3)C2)CC1)N1CCCC1,3.389300000000002
15385,Please modify the molecule CC[C@](C)(CCO)NC(=O)Nc1ccc2c(c1)COC2 to decrease its LogP value.,CC[C@](C)(CCO)NC(=O)Nc1ccc2c(c1)COC2,2.3894
158629,Please modify the molecule Cc1ccc(N2CC[C@H](/C([O-])=N/S(=O)(=O)CCCF)C2=O)cc1C to decrease its LogP value.,Cc1ccc(N2CC[C@H](/C([O-])=N/S(=O)(=O)CCCF)C2=O)cc1C,1.1045399999999996
119959,Please optimize the molecule CSCc1cc(F)ccc1CN[C@H](C(=O)NC(N)=O)c1ccccc1 to have a higher LogP value.,CSCc1cc(F)ccc1CN[C@H](C(=O)NC(N)=O)c1ccccc1,2.714500000000001
168097,Optimize the molecule C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C to have a lower LogP value.,C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C,2.4941000000000004
186701,Modify the molecule COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1 to have a higher LogP value.,COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1,0.24150000000000138
108233,Please optimize the molecule C[C@@H](c1ccccc1)N(C)C(=O)NCc1cc[nH+]c(N2CCCC2)c1 to have a lower LogP value.,C[C@@H](c1ccccc1)N(C)C(=O)NCc1cc[nH+]c(N2CCCC2)c1,3.0035000000000016
59251,Modify the molecule CCOC(=O)c1c(NC(=O)c2nnn(-c3ccc(C)cc3)c2C)sc2c1CC[C@@H](C)C2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)c2nnn(-c3ccc(C)cc3)c2C)sc2c1CC[C@@H](C)C2,4.499440000000004
54828,Optimize the molecule COC(=O)c1ccc2[nH]c3c(c2c1)CN(C(=O)N[C@@H](C)c1ccccc1)CC3 to have a lower LogP value.,COC(=O)c1ccc2[nH]c3c(c2c1)CN(C(=O)N[C@@H](C)c1ccccc1)CC3,3.783400000000002
132234,Optimize the molecule CC(C)[C@@H](C#N)N1CCN(C(=O)C[NH+](C)Cc2ccc(Cl)nc2)CC1 to have a lower LogP value.,CC(C)[C@@H](C#N)N1CCN(C(=O)C[NH+](C)Cc2ccc(Cl)nc2)CC1,0.4420800000000018
228566,Please modify the molecule Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C to increase its LogP value.,Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C,2.3051399999999997
158473,Modify the molecule O=C(OC[C@@H]1[C@H](CO)C1(Cl)Cl)c1ccccc1F to have a lower LogP value.,O=C(OC[C@@H]1[C@H](CO)C1(Cl)Cl)c1ccccc1F,2.3947000000000003
70379,Optimize the molecule Cc1ccc(C(=O)N[C@H]2CCCc3c2cnn3C)c(F)c1 to have a lower LogP value.,Cc1ccc(C(=O)N[C@H]2CCCc3c2cnn3C)c(F)c1,2.675020000000001
201791,Modify the molecule Cc1ccc([C@@H](C)NC(=O)CN(C)c2ccccc2[N+](=O)[O-])o1 to decrease its LogP value.,Cc1ccc([C@@H](C)NC(=O)CN(C)c2ccccc2[N+](=O)[O-])o1,2.809820000000001
35339,Please optimize the molecule COC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1c(Cl)c2ccccc2n1C to have a lower LogP value.,COC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1c(Cl)c2ccccc2n1C,3.2933000000000012
155084,Optimize the molecule CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1cccc(F)c1)N2 to have a lower LogP value.,CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1cccc(F)c1)N2,4.8289000000000035
2982,Please optimize the molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 to have a lower LogP value.,COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1,2.1657
136471,Please optimize the molecule COc1ccc([C@H]2[C@@H](CO)CCC[NH+]2C)cc1 to have a higher LogP value.,COc1ccc([C@H]2[C@@H](CO)CCC[NH+]2C)cc1,0.6532999999999998
103994,Please modify the molecule COC[C@@H]1CN(Cc2nc3cc([N+](=O)[O-])ccc3o2)CCO1 to decrease its LogP value.,COC[C@@H]1CN(Cc2nc3cc([N+](=O)[O-])ccc3o2)CCO1,1.5832
63069,Modify the molecule O=C(NCc1ncc[nH]1)c1c(O)cccc1Cl to have a higher LogP value.,O=C(NCc1ncc[nH]1)c1c(O)cccc1Cl,1.6986999999999999
137625,Please optimize the molecule Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2cc([N+](=O)[O-])cc3c2OCOC3)c1 to have a higher LogP value.,Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2cc([N+](=O)[O-])cc3c2OCOC3)c1,4.379020000000002
126557,Please optimize the molecule CCN(Cc1cccc(C)n1)S(=O)(=O)CCCl to have a lower LogP value.,CCN(Cc1cccc(C)n1)S(=O)(=O)CCCl,1.7805199999999999
123002,Optimize the molecule CCCN[C@@H]1CCOC[C@@H]1[NH+]1CCC(C)(C)C1 to have a lower LogP value.,CCCN[C@@H]1CCOC[C@@H]1[NH+]1CCC(C)(C)C1,0.4583000000000015
206391,Modify the molecule Cc1nc(CC(=O)N[C@@H](c2ccccc2)c2nnc(N)s2)cs1 to have a lower LogP value.,Cc1nc(CC(=O)N[C@@H](c2ccccc2)c2nnc(N)s2)cs1,2.33352
148110,Please optimize the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)N[C@@H](C)C(C)C)C2)c1 to have a lower LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)N[C@@H](C)C(C)C)C2)c1,2.4508
145833,Optimize the molecule Cc1cc(-c2nnc(-c3ccccc3Br)o2)ccc1[N+](=O)[O-] to have a lower LogP value.,Cc1cc(-c2nnc(-c3ccccc3Br)o2)ccc1[N+](=O)[O-],4.382720000000003
71441,Modify the molecule CCSc1ccc([C@@H](C)NC(=O)C(=O)Nc2cncc(C)c2)cc1 to increase its LogP value.,CCSc1ccc([C@@H](C)NC(=O)C(=O)Nc2cncc(C)c2)cc1,3.3179200000000018
122455,Please modify the molecule C[C@H](CCCO)[NH2+]Cc1nnc(-c2ccccc2)o1 to increase its LogP value.,C[C@H](CCCO)[NH2+]Cc1nnc(-c2ccccc2)o1,0.9610000000000001
224706,Modify the molecule C[NH+]1CCC[C@@H]1C(=O)N1CCNCC1 to decrease its LogP value.,C[NH+]1CCC[C@@H]1C(=O)N1CCNCC1,-1.9046999999999967
71436,Modify the molecule Cc1cc(S(N)(=O)=O)cc(C(=O)N[C@@H](CO)c2ccccc2F)c1C to decrease its LogP value.,Cc1cc(S(N)(=O)=O)cc(C(=O)N[C@@H](CO)c2ccccc2F)c1C,1.55334
67457,Optimize the molecule CC(C)[NH+](CC(C)(C)CCC#N)C1CCC1 to have a higher LogP value.,CC(C)[NH+](CC(C)(C)CCC#N)C1CCC1,2.1621799999999993
144291,Optimize the molecule CC(=O)Nc1ccc(N2C[C@H](C(=O)Nc3cc(C)ccn3)CC2=O)cc1 to have a higher LogP value.,CC(=O)Nc1ccc(N2C[C@H](C(=O)Nc3cc(C)ccn3)CC2=O)cc1,2.34002
129648,Please optimize the molecule Cc1ccc(S(=O)(=O)[N-]c2cccc(Cl)c2F)cc1C to have a higher LogP value.,Cc1ccc(S(=O)(=O)[N-]c2cccc(Cl)c2F)cc1C,4.490040000000003
78569,Please modify the molecule Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1 to increase its LogP value.,Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1,4.135020000000003
62198,Modify the molecule N#Cc1ccccc1N[C@H]1c2ccccc2C(=O)N1Cc1ccccc1Cl to have a higher LogP value.,N#Cc1ccccc1N[C@H]1c2ccccc2C(=O)N1Cc1ccccc1Cl,4.978380000000002
188322,Modify the molecule Cc1nn(C)c2ncc(NC(=O)C(=O)N(C)Cc3ccccc3F)cc12 to decrease its LogP value.,Cc1nn(C)c2ncc(NC(=O)C(=O)N(C)Cc3ccccc3F)cc12,2.0129199999999994
233617,Optimize the molecule CC[C@@H](C)c1ccccc1OCC(=O)N1CCC[C@H]([NH+]2CCCC2)C1 to have a higher LogP value.,CC[C@@H](C)c1ccccc1OCC(=O)N1CCC[C@H]([NH+]2CCCC2)C1,2.2485999999999997
232673,Please modify the molecule CN(C(=O)[O-])c1ccc2c(c1)CCN2 to increase its LogP value.,CN(C(=O)[O-])c1ccc2c(c1)CCN2,0.4341
73899,Please modify the molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2c(C)cc(C)cc2C)C1 to decrease its LogP value.,CCOC[C@@H]1CC[NH+](CC(=O)Nc2c(C)cc(C)cc2C)C1,1.4916600000000002
148838,Modify the molecule Cc1c(C(=O)N2CCc3c(sc(N)c3C#N)C2)cnn1CCC(C)C to have a higher LogP value.,Cc1c(C(=O)N2CCc3c(sc(N)c3C#N)C2)cnn1CCC(C)C,2.951500000000001
226282,Please optimize the molecule O=C1CC[NH2+][C@H](c2ccccc2)C1 to have a lower LogP value.,O=C1CC[NH2+][C@H](c2ccccc2)C1,0.6539999999999999
154695,Please modify the molecule C[C@@H]1CCCC[C@@H]1OCC[C@@H]1CCC[C@]1([NH3+])CO to increase its LogP value.,C[C@@H]1CCCC[C@@H]1OCC[C@@H]1CCC[C@]1([NH3+])CO,1.7449
29298,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc3c(c2)OC2(CCCC2)O3)C1 to have a lower LogP value.,C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc3c(c2)OC2(CCCC2)O3)C1,3.361500000000002
149317,Optimize the molecule CC(C)(C)c1noc(CCC(=O)N[C@@H]2CCC[C@@H](S(C)(=O)=O)C2)n1 to have a higher LogP value.,CC(C)(C)c1noc(CCC(=O)N[C@@H]2CCC[C@@H](S(C)(=O)=O)C2)n1,1.7717
113831,Please optimize the molecule CN1CC[C@]2(CCC1=O)CN(Cc1ccc(C3CCCC3)s1)CC[NH+]2C to have a lower LogP value.,CN1CC[C@]2(CCC1=O)CN(Cc1ccc(C3CCCC3)s1)CC[NH+]2C,2.1170999999999998
222037,Please optimize the molecule Cc1cc(Sc2nc(NC(C)C)nc(NC(C)C)n2)nc(Cl)n1 to have a lower LogP value.,Cc1cc(Sc2nc(NC(C)C)nc(NC(C)C)n2)nc(Cl)n1,3.4152200000000015
128040,Optimize the molecule O=C(/C=C/c1ccccc1)C1=C(O)C(=O)N(c2ccccc2)[C@@H]1c1ccccc1F to have a higher LogP value.,O=C(/C=C/c1ccccc1)C1=C(O)C(=O)N(c2ccccc2)[C@@H]1c1ccccc1F,5.008200000000004
93427,Modify the molecule Cc1cc(C)c(NC(=O)c2cccc(OCCC(C)C)c2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(NC(=O)c2cccc(OCCC(C)C)c2)c(C)c1,5.2890600000000045
61909,Modify the molecule Cc1nn(-c2ccccc2)c(N2CCCC2)c1/C=N/NC(=O)CNc1ccccc1 to increase its LogP value.,Cc1nn(-c2ccccc2)c(N2CCCC2)c1/C=N/NC(=O)CNc1ccccc1,3.3431200000000008
168828,Modify the molecule NC(=O)NC(=O)OCCC[NH+]1CC[C@H](c2ccc(F)cc2)C1 to decrease its LogP value.,NC(=O)NC(=O)OCCC[NH+]1CC[C@H](c2ccc(F)cc2)C1,0.39290000000000025
73394,Optimize the molecule CN(CCS(C)(=O)=O)c1n[nH]c(=S)n1C1CCCCC1 to have a higher LogP value.,CN(CCS(C)(=O)=O)c1n[nH]c(=S)n1C1CCCCC1,1.9266899999999998
123318,Optimize the molecule COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1 to have a higher LogP value.,COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1,0.7850000000000001
60588,Modify the molecule CCc1ccc(C(=O)N[C@H](C(=O)[O-])[C@H](C)CC)o1 to decrease its LogP value.,CCc1ccc(C(=O)N[C@H](C(=O)[O-])[C@H](C)CC)o1,0.7363999999999997
24522,Modify the molecule CCc1cnc(C[NH+](C)Cc2c(CC)nn(C)c2CC)s1 to decrease its LogP value.,CCc1cnc(C[NH+](C)Cc2c(CC)nn(C)c2CC)s1,1.7786999999999997
184920,Please optimize the molecule CC[C@H](C)CS(=O)(=O)c1cccc(Br)c1 to have a higher LogP value.,CC[C@H](C)CS(=O)(=O)c1cccc(Br)c1,3.268900000000002
202763,Modify the molecule O=[N+]([O-])c1ccc([C@H]2OCN3COC[C@@H]23)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc([C@H]2OCN3COC[C@@H]23)cc1,1.2818999999999998
179734,Optimize the molecule O=C(Nc1cc([N+](=O)[O-])ccc1O)c1cccc(Cl)c1F to have a lower LogP value.,O=C(Nc1cc([N+](=O)[O-])ccc1O)c1cccc(Cl)c1F,3.3452
73141,Modify the molecule C#CCOc1cc(F)ccc1NCc1ccc(C(=O)OC)o1 to decrease its LogP value.,C#CCOc1cc(F)ccc1NCc1ccc(C(=O)OC)o1,2.8294000000000006
210399,Optimize the molecule CC1(C)[C@H]2CC[C@]1(C)[C@](O)(CC(=O)[O-])C2 to have a lower LogP value.,CC1(C)[C@H]2CC[C@]1(C)[C@](O)(CC(=O)[O-])C2,0.7037
42922,Modify the molecule Cc1cc(N2CCC[C@H](C(=O)[O-])C2)nc(C(C)C)[nH+]1 to have a lower LogP value.,Cc1cc(N2CCC[C@H](C(=O)[O-])C2)nc(C(C)C)[nH+]1,0.29382
215517,Modify the molecule CCOc1cc(Nc2ccc(C#N)cn2)ccc1OC to have a higher LogP value.,CCOc1cc(Nc2ccc(C#N)cn2)ccc1OC,3.1041800000000013
121837,Modify the molecule C[C@H](NC(=O)NCC1(O)CCCCCC1)C(=O)N1CCCC[C@@H]1C to have a higher LogP value.,C[C@H](NC(=O)NCC1(O)CCCCCC1)C(=O)N1CCCC[C@@H]1C,2.160399999999999
181471,Please modify the molecule O=[N+]([O-])c1ccc(Nn2cccc2)cn1 to increase its LogP value.,O=[N+]([O-])c1ccc(Nn2cccc2)cn1,1.6664999999999999
43931,Please optimize the molecule Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)C3CCCC3)sc2c1 to have a higher LogP value.,Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)C3CCCC3)sc2c1,4.306920000000003
237384,Modify the molecule C[C@H](CC1CCCC1)[NH2+]C1CCN(S(=O)(=O)C2CC2)CC1 to increase its LogP value.,C[C@H](CC1CCCC1)[NH2+]C1CCN(S(=O)(=O)C2CC2)CC1,1.4752000000000007
213409,Modify the molecule O=C(NCc1ccc(C(=O)N2CCCC2)cc1)[C@@H](O)c1ccccc1 to have a higher LogP value.,O=C(NCc1ccc(C(=O)N2CCCC2)cc1)[C@@H](O)c1ccccc1,2.2724
223661,Please modify the molecule Cc1cc2nc(CSc3nnc(/N=C(\[O-])c4cccs4)s3)cc(=O)n2o1 to increase its LogP value.,Cc1cc2nc(CSc3nnc(/N=C(\[O-])c4cccs4)s3)cc(=O)n2o1,2.23982
212205,Modify the molecule CC[NH+](C[C@@H]1CCCC(C)(C)C1=O)C1CC1 to have a lower LogP value.,CC[NH+](C[C@@H]1CCCC(C)(C)C1=O)C1CC1,1.4489999999999992
46497,Optimize the molecule O=C(Nc1cnc2ccccc2c1)c1sccc1-c1ccc(F)cc1 to have a higher LogP value.,O=C(Nc1cnc2ccccc2c1)c1sccc1-c1ccc(F)cc1,5.354700000000003
66142,Please modify the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)NCCc3cccc(Cl)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)NCCc3cccc(Cl)c3)CC2)cc1,2.907020000000001
194525,Modify the molecule O=C(NCCCNC(=O)C1CCC1)N[C@H]1CCc2ccccc21 to have a higher LogP value.,O=C(NCCCNC(=O)C1CCC1)N[C@H]1CCc2ccccc21,2.2794999999999996
136214,Modify the molecule COCCn1c(SCc2ncc(C(C)(C)C)o2)nc2ccccc21 to increase its LogP value.,COCCn1c(SCc2ncc(C(C)(C)C)o2)nc2ccccc21,4.260500000000004
167424,Modify the molecule COc1cc(C[NH3+])ccc1OCC(C)C to decrease its LogP value.,COc1cc(C[NH3+])ccc1OCC(C)C,1.4718999999999998
82593,Modify the molecule COc1cc([C@@H](C)NC(=O)c2ccncc2F)ccc1OC(C)C to decrease its LogP value.,COc1cc([C@@H](C)NC(=O)c2ccncc2F)ccc1OC(C)C,3.507500000000002
163581,Please modify the molecule Cc1ccc(-c2nc(C)c(C(=O)N(C)C3CC[NH+](C)CC3)s2)c(C)c1 to increase its LogP value.,Cc1ccc(-c2nc(C)c(C(=O)N(C)C3CC[NH+](C)CC3)s2)c(C)c1,2.4844600000000003
163842,Please modify the molecule CN(C)S(=O)(=O)N1CC=C(c2c[nH]c3ccccc23)CC1 to decrease its LogP value.,CN(C)S(=O)(=O)N1CC=C(c2c[nH]c3ccccc23)CC1,2.0634
199707,Modify the molecule O=C(NC[C@@H](c1ccco1)[NH+]1CCCC1)N[C@@H]1CCc2c(O)cccc21 to increase its LogP value.,O=C(NC[C@@H](c1ccco1)[NH+]1CCCC1)N[C@@H]1CCc2c(O)cccc21,1.691699999999999
34104,Optimize the molecule COc1ccc(S(=O)(=O)NCC2CC[NH+](Cc3ccsc3)CC2)cc1F to have a higher LogP value.,COc1ccc(S(=O)(=O)NCC2CC[NH+](Cc3ccsc3)CC2)cc1F,1.6692
241949,Please modify the molecule Cc1ccsc1CNC(=O)[C@@]1(C)COC[C@H]1[NH3+] to decrease its LogP value.,Cc1ccsc1CNC(=O)[C@@]1(C)COC[C@H]1[NH3+],0.3197200000000004
42375,Modify the molecule COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC to increase its LogP value.,COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC,3.1685000000000016
239257,Please optimize the molecule COC(OC)c1csc(N2CCCC2)n1 to have a higher LogP value.,COC(OC)c1csc(N2CCCC2)n1,2.0347
141429,Optimize the molecule N#Cc1c([O-])nc(SCc2nc3ccccc3c(=O)[nH]2)nc1-c1ccccc1 to have a higher LogP value.,N#Cc1c([O-])nc(SCc2nc3ccccc3c(=O)[nH]2)nc1-c1ccccc1,2.617680000000001
143414,Modify the molecule COC(=O)c1nn(C[C@@H](O)COc2cc(C)cc(C)c2)c2c1CCCC2 to increase its LogP value.,COC(=O)c1nn(C[C@@H](O)COc2cc(C)cc(C)c2)c2c1CCCC2,2.6052400000000002
27842,Modify the molecule O=C([C@H]1CC[C@@H]2CCCC[C@H]2C1)N1CCC(O)(C(F)(F)F)CC1 to increase its LogP value.,O=C([C@H]1CC[C@@H]2CCCC[C@H]2C1)N1CCC(O)(C(F)(F)F)CC1,3.508700000000003
156045,Modify the molecule Cc1cnn(C[C@H]2CCCCN2C(=O)c2cc3ccccc3[nH]2)c1 to decrease its LogP value.,Cc1cnn(C[C@H]2CCCCN2C(=O)c2cc3ccccc3[nH]2)c1,3.367720000000001
95802,Please optimize the molecule CCn1c(SCC(N)=O)nc2scc(-c3ccc(Cl)cc3)c2c1=O to have a higher LogP value.,CCn1c(SCC(N)=O)nc2scc(-c3ccc(Cl)cc3)c2c1=O,3.375700000000001
197319,Modify the molecule COc1cc2c(cc1C[NH2+]C[C@H]1CCc3nncn3C1)O[C@@H](C)C2 to increase its LogP value.,COc1cc2c(cc1C[NH2+]C[C@H]1CCc3nncn3C1)O[C@@H](C)C2,0.9360999999999995
94625,Please optimize the molecule CCc1cc(=O)[nH]c(-c2ccc(NCCc3nc(C(C)(C)C)cs3)nc2)n1 to have a higher LogP value.,CCc1cc(=O)[nH]c(-c2ccc(NCCc3nc(C(C)(C)C)cs3)nc2)n1,3.802900000000003
17674,Modify the molecule C[C@H](Oc1ccc(/C=N/c2ccc(Cl)cc2Cl)cc1)C(=O)[O-] to have a lower LogP value.,C[C@H](Oc1ccc(/C=N/c2ccc(Cl)cc2Cl)cc1)C(=O)[O-],3.2612000000000023
100038,Please optimize the molecule O=C(N/N=C\c1cccnc1)c1ccc(COc2ccc(Cl)cc2)cc1 to have a higher LogP value.,O=C(N/N=C\c1cccnc1)c1ccc(COc2ccc(Cl)cc2)cc1,4.077900000000002
193435,Optimize the molecule O=C([C@@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)N1CCOC[C@@H]1C1CC1 to have a lower LogP value.,O=C([C@@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)N1CCOC[C@@H]1C1CC1,3.734300000000003
170565,Optimize the molecule CNC(=O)c1ccc(C[NH2+]C2CCCCCCC2)cc1 to have a higher LogP value.,CNC(=O)c1ccc(C[NH2+]C2CCCCCCC2)cc1,2.2224999999999993
166392,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)C[NH+](C)CC2CC[NH2+]CC2)[C@@H]1C to decrease its LogP value.,C[C@H]1CCC[C@@H](NC(=O)C[NH+](C)CC2CC[NH2+]CC2)[C@@H]1C,-0.5845999999999958
115061,Modify the molecule Cc1cc(CN2CCN(C(=O)CCCOc3ccccc3C)CC2)no1 to decrease its LogP value.,Cc1cc(CN2CCN(C(=O)CCCOc3ccccc3C)CC2)no1,2.7948400000000015
214038,Modify the molecule Clc1ccnc(CSc2nnc3n2CCCCC3)c1 to decrease its LogP value.,Clc1ccnc(CSc2nnc3n2CCCCC3)c1,3.345200000000001
96007,Modify the molecule Cc1ccc(N(C)C(=O)[C@H]2CCO[C@@H]2C)c(C)c1 to decrease its LogP value.,Cc1ccc(N(C)C(=O)[C@H]2CCO[C@@H]2C)c(C)c1,2.6912400000000005
16039,Modify the molecule C[C@H](Nc1ncnc(Sc2ccc(Cl)cc2)c1N)c1ccccc1 to increase its LogP value.,C[C@H](Nc1ncnc(Sc2ccc(Cl)cc2)c1N)c1ccccc1,5.036500000000003
241865,Modify the molecule CCOc1ccccc1OCCN1CCc2sccc2C1 to decrease its LogP value.,CCOc1ccccc1OCCN1CCc2sccc2C1,3.5839000000000025
33787,Please optimize the molecule CCCSc1nnc(NC(=O)[C@H](C)Oc2cc(C)c(Cl)c(C)c2)s1 to have a higher LogP value.,CCCSc1nnc(NC(=O)[C@H](C)Oc2cc(C)c(Cl)c(C)c2)s1,4.716440000000004
139037,Optimize the molecule CC(C)(C(=O)c1cncc2ccccc12)N1CCOCC1 to have a lower LogP value.,CC(C)(C(=O)c1cncc2ccccc12)N1CCOCC1,2.5283000000000007
31981,Please modify the molecule Cc1c(C(=O)N[C@H]2C=CCCC2)cnn1C(C)C to increase its LogP value.,Cc1c(C(=O)N[C@H]2C=CCCC2)cnn1C(C)C,2.610920000000001
178953,Please optimize the molecule CC(C)[C@H](NCC(=O)Nc1ccc(Br)cc1)c1cccnc1 to have a lower LogP value.,CC(C)[C@H](NCC(=O)Nc1ccc(Br)cc1)c1cccnc1,3.7695000000000016
138147,Modify the molecule [NH3+][C@H]1CCC[C@@H]1CC[S@@](=O)c1ccc2c(c1)CCC2 to have a higher LogP value.,[NH3+][C@H]1CCC[C@@H]1CC[S@@](=O)c1ccc2c(c1)CCC2,2.083599999999999
95565,Please modify the molecule Clc1cc2c(c(CSc3nncn3CCc3ccccn3)c1)OCOC2 to increase its LogP value.,Clc1cc2c(c(CSc3nncn3CCc3ccccn3)c1)OCOC2,3.7280000000000033
55045,Please modify the molecule CC(C)CC(=O)N1CCN(c2cccc[nH+]2)CC1 to increase its LogP value.,CC(C)CC(=O)N1CCN(c2cccc[nH+]2)CC1,1.1954
143364,Please optimize the molecule CCc1ocnc1C(=O)Nc1ccn(-c2ccc(Cl)cc2Cl)n1 to have a higher LogP value.,CCc1ocnc1C(=O)Nc1ccn(-c2ccc(Cl)cc2Cl)n1,3.9818000000000024
195511,Modify the molecule CCOC(=O)c1c(NC(=O)N/N=C\CC(C)C)sc2c1CCC2 to decrease its LogP value.,CCOC(=O)c1c(NC(=O)N/N=C\CC(C)C)sc2c1CCC2,3.566900000000002
49578,Modify the molecule Cc1cc([NH+]2CCCC[C@@H]2C)cc(C(=O)[O-])c1N to increase its LogP value.,Cc1cc([NH+]2CCCC[C@@H]2C)cc(C(=O)[O-])c1N,0.029520000000000546
154792,Please optimize the molecule O=C([O-])CCc1cc2n(n1)CCN(Cc1ccc3[nH]ccc3c1)C2 to have a higher LogP value.,O=C([O-])CCc1cc2n(n1)CCN(Cc1ccc3[nH]ccc3c1)C2,1.0626999999999993
122533,Modify the molecule COc1ccccc1[C@@H]1CCCN1C(=O)C[NH+](C)[C@@H]1CCS(=O)(=O)C1 to increase its LogP value.,COc1ccccc1[C@@H]1CCCN1C(=O)C[NH+](C)[C@@H]1CCS(=O)(=O)C1,0.060500000000002
208321,Please optimize the molecule O=C(c1ccccc1[N-]S(=O)(=O)c1ccccc1[N+](=O)[O-])N1CCCC1 to have a lower LogP value.,O=C(c1ccccc1[N-]S(=O)(=O)c1ccccc1[N+](=O)[O-])N1CCCC1,3.2249000000000017
219303,Modify the molecule N#Cc1ccc(CNCC(=O)NCCc2ccccc2)cc1 to have a lower LogP value.,N#Cc1ccc(CNCC(=O)NCCc2ccccc2)cc1,2.0067799999999996
244912,Modify the molecule CC(C)(C)[C@H](NCc1cc(=O)n2nccc2[nH]1)c1cccs1 to have a higher LogP value.,CC(C)(C)[C@H](NCc1cc(=O)n2nccc2[nH]1)c1cccs1,2.961100000000001
136443,Modify the molecule CCn1ncc(C[NH2+]C(C)C)c1C(F)(F)F to have a lower LogP value.,CCn1ncc(C[NH2+]C(C)C)c1C(F)(F)F,1.3936000000000002
204864,Please optimize the molecule Clc1cccc(-c2cc(Br)ccn2)n1 to have a higher LogP value.,Clc1cccc(-c2cc(Br)ccn2)n1,3.5595000000000017
139382,Modify the molecule C[C@H]1CN(Cc2ccc(C[NH2+]Cc3c(F)cccc3Cl)cc2)C[C@@H](C)O1 to decrease its LogP value.,C[C@H]1CN(Cc2ccc(C[NH2+]Cc3c(F)cccc3Cl)cc2)C[C@@H](C)O1,3.3519000000000014
44099,Modify the molecule CCOC1CCN(C(=O)C(=O)Nc2ccc3c(c2)C(=O)CCC3)CC1 to have a higher LogP value.,CCOC1CCN(C(=O)C(=O)Nc2ccc3c(c2)C(=O)CCC3)CC1,2.1715999999999998
194015,Please modify the molecule O=C(Cc1ccc(F)c(F)c1)NCCN1CCOCC1 to increase its LogP value.,O=C(Cc1ccc(F)c(F)c1)NCCN1CCOCC1,0.9557
74954,Please modify the molecule O=C(CCn1cccn1)N1CCSCC1 to decrease its LogP value.,O=C(CCn1cccn1)N1CCSCC1,0.8485999999999999
695,Optimize the molecule Cc1ccccc1Nc1nc(N)nc(COc2ccc(F)c(Cl)c2)n1 to have a lower LogP value.,Cc1ccccc1Nc1nc(N)nc(COc2ccc(F)c(Cl)c2)n1,3.877320000000002
25203,Optimize the molecule CC[NH+](CC)C1([C@@H](N)Cc2ccc(F)cc2F)CCCC1 to have a higher LogP value.,CC[NH+](CC)C1([C@@H](N)Cc2ccc(F)cc2F)CCCC1,2.0721000000000003
26252,Please modify the molecule CCOC(=O)CN(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 to decrease its LogP value.,CCOC(=O)CN(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1,3.0984000000000016
67153,Modify the molecule CCOC(=O)[C@@H]1CCC[NH+](Cc2c(O)cc(C)c3c2O/C(=C\c2ccc(N(C)C)cc2)C3=O)C1 to decrease its LogP value.,CCOC(=O)[C@@H]1CCC[NH+](Cc2c(O)cc(C)c3c2O/C(=C\c2ccc(N(C)C)cc2)C3=O)C1,2.740820000000001
111483,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(-c3nc4ccccc4s3)o2)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(-c3nc4ccccc4s3)o2)CC1,5.047200000000004
196441,Please modify the molecule CCC(CC)[NH2+]CCc1nncn1C1CC1 to increase its LogP value.,CCC(CC)[NH2+]CCc1nncn1C1CC1,0.9074999999999995
244287,Please optimize the molecule Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1 to have a higher LogP value.,Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1,2.5197400000000005
100457,Modify the molecule C[C@]12CCC[C@@H]1[C@@H]1CC(=O)[C@H]3CC(=O)CC[C@]3(C)[C@@H]1CC2 to decrease its LogP value.,C[C@]12CCC[C@@H]1[C@@H]1CC(=O)[C@H]3CC(=O)CC[C@]3(C)[C@@H]1CC2,4.167300000000004
188821,Modify the molecule Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Br)cc32)c(C)c1 to have a lower LogP value.,Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Br)cc32)c(C)c1,3.5029400000000024
245882,Modify the molecule O[C@H]([C@H]1CCCc2cccnc21)[C@H]1CC=CCC1 to have a higher LogP value.,O[C@H]([C@H]1CCCc2cccnc21)[C@H]1CC=CCC1,3.218700000000002
54266,Please modify the molecule CCCN/C(N)=[NH+]/CC[C@@H](C)SC to decrease its LogP value.,CCCN/C(N)=[NH+]/CC[C@@H](C)SC,-0.4770999999999981
197423,Modify the molecule Cc1ccc(-n2ccn3c(SCC(=O)Nc4cccc(F)c4)nnc3c2=O)cc1C to increase its LogP value.,Cc1ccc(-n2ccn3c(SCC(=O)Nc4cccc(F)c4)nnc3c2=O)cc1C,3.3669400000000014
3234,Please modify the molecule CN(C[C@@H]1CC[NH+](C)C1)C(=O)N[C@@H](Cc1ccccc1)C1CC1 to increase its LogP value.,CN(C[C@@H]1CC[NH+](C)C1)C(=O)N[C@@H](Cc1ccccc1)C1CC1,1.183700000000001
129429,Modify the molecule Cn1c(CN2CCSCC2)cc(=O)c(O)c1CN1CCN(S(C)(=O)=O)CC1 to have a higher LogP value.,Cn1c(CN2CCSCC2)cc(=O)c(O)c1CN1CCN(S(C)(=O)=O)CC1,-0.28309999999999813
178005,Modify the molecule Cc1ccc(CCNC(=O)C(=O)Nc2ccc(F)c(-n3nnnc3C)c2)c(C)c1 to have a higher LogP value.,Cc1ccc(CCNC(=O)C(=O)Nc2ccc(F)c(-n3nnnc3C)c2)c(C)c1,2.0240599999999995
178265,Please modify the molecule O=C(NCC[NH+]1CCCCC1)NNc1ccccc1Cl to increase its LogP value.,O=C(NCC[NH+]1CCCCC1)NNc1ccccc1Cl,1.0349
116731,Please optimize the molecule CS(=O)(=O)N1C[C@H]2C[NH2+]C[C@@]2(C(=O)N2CC=CC2)C1 to have a lower LogP value.,CS(=O)(=O)N1C[C@H]2C[NH2+]C[C@@]2(C(=O)N2CC=CC2)C1,-2.1603999999999957
229081,Modify the molecule O=C(N[C@H]1C[C@@H]2CCCc3cccc1c32)N1CCN(CC(F)F)CC1 to have a higher LogP value.,O=C(N[C@H]1C[C@@H]2CCCc3cccc1c32)N1CCN(CC(F)F)CC1,3.143600000000002
89440,Modify the molecule CCOC(=O)C1=C(Cn2cnc3ccccc3c2=O)NC(=O)N[C@H]1c1ccccc1 to have a lower LogP value.,CCOC(=O)C1=C(Cn2cnc3ccccc3c2=O)NC(=O)N[C@H]1c1ccccc1,2.2678000000000003
35858,Please optimize the molecule CC1CCN(C(=O)NCC2(c3ccc(Cl)cc3)CC2)CC1 to have a lower LogP value.,CC1CCN(C(=O)NCC2(c3ccc(Cl)cc3)CC2)CC1,3.813100000000003
48830,Optimize the molecule CC(C)OC(=O)[C@@H](C)CNC(=O)/C(C#N)=C\c1ccco1 to have a lower LogP value.,CC(C)OC(=O)[C@@H](C)CNC(=O)/C(C#N)=C\c1ccco1,1.89048
94205,Modify the molecule Cc1ccc(S(=O)(=O)CCCOc2cc(C)n(C)n2)cc1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)CCCOc2cc(C)n(C)n2)cc1,2.2797400000000003
142958,Modify the molecule CC(C)SSC(=O)N1CCC[C@@H]1C(=O)[O-] to have a lower LogP value.,CC(C)SSC(=O)N1CCC[C@@H]1C(=O)[O-],1.1105
204224,Please optimize the molecule C[C@H]1C[C@@H]1C(=O)NCC1(c2ccc(F)cc2F)CC1 to have a higher LogP value.,C[C@H]1C[C@@H]1C(=O)NCC1(c2ccc(F)cc2F)CC1,2.768600000000001
217315,Please optimize the molecule CC[C@H]1CC[C@](CC(C)(C)O)(C(=O)[O-])C1 to have a higher LogP value.,CC[C@H]1CC[C@](CC(C)(C)O)(C(=O)[O-])C1,1.0937999999999999
7840,Please optimize the molecule CC(=O)N1CCc2[nH]c3ccc(C(=O)N4CCCC4)cc3c2C1 to have a lower LogP value.,CC(=O)N1CCc2[nH]c3ccc(C(=O)N4CCCC4)cc3c2C1,2.3085000000000004
201751,Optimize the molecule CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1 to have a lower LogP value.,CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1,4.749300000000003
116082,Optimize the molecule N#CCN1CCN(c2ncnc3sc4c(c23)CCCC4)CC1 to have a lower LogP value.,N#CCN1CCN(c2ncnc3sc4c(c23)CCCC4)CC1,2.21568
211915,Modify the molecule CN(Cc1ccccc1)c1[nH+]cccc1CNC(=O)c1ccncc1F to have a higher LogP value.,CN(Cc1ccccc1)c1[nH+]cccc1CNC(=O)c1ccncc1F,2.6012000000000004
78403,Modify the molecule Cc1ccccc1NC(=O)N1C[C@H](C)Sc2ccccc21 to increase its LogP value.,Cc1ccccc1NC(=O)N1C[C@H](C)Sc2ccccc21,4.527720000000003
82133,Modify the molecule CCO[C@@H]1CCCN(C(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)C1 to decrease its LogP value.,CCO[C@@H]1CCCN(C(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)C1,3.1611600000000015
199306,Optimize the molecule Cc1cccc(C)c1OCCC[NH2+]C1(C(N)=O)CCCCC1 to have a lower LogP value.,Cc1cccc(C)c1OCCC[NH2+]C1(C(N)=O)CCCCC1,1.823939999999999
207378,Please optimize the molecule COC(=O)C1=C(N)OC2=C(CC(=O)C(C)(C)C2)[C@@]12C(=O)Nc1ccccc12 to have a lower LogP value.,COC(=O)C1=C(N)OC2=C(CC(=O)C(C)(C)C2)[C@@]12C(=O)Nc1ccccc12,1.893199999999999
244724,Modify the molecule Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-] to decrease its LogP value.,Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-],-0.6575000000000002
128024,Please modify the molecule CCO[C@H](NC(=O)c1ccccc1)c1cccc2ccccc12 to increase its LogP value.,CCO[C@H](NC(=O)c1ccccc1)c1cccc2ccccc12,4.304900000000003
190151,Please modify the molecule CCn1c(C)c(C(=O)NC2(C(N)=O)CCCC2)c2cc(OC)ccc21 to decrease its LogP value.,CCn1c(C)c(C(=O)NC2(C(N)=O)CCCC2)c2cc(OC)ccc21,2.50612
15924,Modify the molecule COc1cc2c(cc1OC)[C@H](c1ccccc1)N(S(=O)(=O)c1ccc(F)cc1)CC2 to increase its LogP value.,COc1cc2c(cc1OC)[C@H](c1ccccc1)N(S(=O)(=O)c1ccc(F)cc1)CC2,4.179300000000003
38517,Modify the molecule CCn1cc(NC(=O)c2c(F)ccc(N)c2F)ccc1=O to increase its LogP value.,CCn1cc(NC(=O)c2c(F)ccc(N)c2F)ccc1=O,1.9808999999999999
174202,Optimize the molecule C[C@H]1CCCC[NH+]1CCCNC(=O)C(=O)NCC#N to have a higher LogP value.,C[C@H]1CCCC[NH+]1CCCNC(=O)C(=O)NCC#N,-1.4102199999999967
18210,Please optimize the molecule COc1ccc(CCNC(=O)C2CN(S(C)(=O)=O)C2)cc1OC to have a higher LogP value.,COc1ccc(CCNC(=O)C2CN(S(C)(=O)=O)C2)cc1OC,0.25390000000000135
233050,Optimize the molecule CC[NH+]1CCC[C@H]1CN(C)CC(N)=O to have a lower LogP value.,CC[NH+]1CCC[C@H]1CN(C)CC(N)=O,-1.5292999999999959
106863,Please optimize the molecule C=CC[NH+](Cc1cc(C)cc(C)c1)[C@@H]1CCS(=O)(=O)C1 to have a higher LogP value.,C=CC[NH+](Cc1cc(C)cc(C)c1)[C@@H]1CCS(=O)(=O)C1,1.0614399999999995
237801,Modify the molecule Nn1c(SCc2c(F)cccc2Cl)nnc1-c1ccc(Cl)cc1 to have a lower LogP value.,Nn1c(SCc2c(F)cccc2Cl)nnc1-c1ccc(Cl)cc1,4.397100000000002
163492,Please optimize the molecule CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O to have a higher LogP value.,CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O,2.24022
161923,Modify the molecule C[C@@H]1C[C@H]1c1ccc(CN(C)C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)o1 to have a higher LogP value.,C[C@@H]1C[C@H]1c1ccc(CN(C)C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)o1,3.1525000000000016
146480,Modify the molecule CCc1nn(C)cc1CNC(=O)Nc1cc(F)cc(OC)c1 to have a higher LogP value.,CCc1nn(C)cc1CNC(=O)Nc1cc(F)cc(OC)c1,2.451900000000001
165035,Modify the molecule O=C(CSc1nnc(-c2cccnc2)o1)N(C1CCCCC1)[C@@H]1CCS(=O)(=O)C1 to decrease its LogP value.,O=C(CSc1nnc(-c2cccnc2)o1)N(C1CCCCC1)[C@@H]1CCS(=O)(=O)C1,2.5721000000000007
49433,Please optimize the molecule CC[C@H]1Oc2ccc(C)cc2N(CC(=O)NCCC[NH+]2C[C@@H](C)C[C@H](C)C2)C1=O to have a lower LogP value.,CC[C@H]1Oc2ccc(C)cc2N(CC(=O)NCCC[NH+]2C[C@@H](C)C[C@H](C)C2)C1=O,1.566120000000001
23750,Optimize the molecule CCc1nn(C)cc1CNc1ccc(NC(C)=O)c(OC)c1 to have a lower LogP value.,CCc1nn(C)cc1CNc1ccc(NC(C)=O)c(OC)c1,2.5616000000000003
245265,Optimize the molecule CC(=O)c1ccc(OCC(=O)Oc2ccc(C)cc2Br)cc1 to have a lower LogP value.,CC(=O)c1ccc(OCC(=O)Oc2ccc(C)cc2Br)cc1,3.9445200000000034
3295,Modify the molecule Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1 to have a higher LogP value.,Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1,2.2053199999999995
243284,Please optimize the molecule Cc1ccc(C)c(NC(=O)CS[C@H]2N=N[C@@H]([C@@H]([NH3+])CC3=c4ccccc4=[NH+]C3)O2)c1 to have a lower LogP value.,Cc1ccc(C)c(NC(=O)CS[C@H]2N=N[C@@H]([C@@H]([NH3+])CC3=c4ccccc4=[NH+]C3)O2)c1,-0.3674599999999979
133554,Modify the molecule Br[C@H]1c2ccccc2CCC[C@H]1Cc1nccs1 to decrease its LogP value.,Br[C@H]1c2ccccc2CCC[C@H]1Cc1nccs1,4.774300000000003
28225,Modify the molecule Cc1csc(CSCC(=O)N(C)[C@H]2CCCc3ccccc32)n1 to have a lower LogP value.,Cc1csc(CSCC(=O)N(C)[C@H]2CCCc3ccccc32)n1,4.220720000000004
208048,Optimize the molecule CC(C)c1ocnc1C(=O)N(C)[C@@H](C)c1ccc([S@](C)=O)cc1 to have a higher LogP value.,CC(C)c1ocnc1C(=O)N(C)[C@@H](C)c1ccc([S@](C)=O)cc1,3.3686000000000025
81393,Modify the molecule C[C@H]1[C@@H]([NH3+])CCN(Cc2ccccc2Cl)[C@@H]1C to increase its LogP value.,C[C@H]1[C@@H]([NH3+])CCN(Cc2ccccc2Cl)[C@@H]1C,2.1807999999999996
184658,Optimize the molecule CCc1cccc(NC(=O)C(=O)N[C@@H](Cn2cncn2)c2ccccc2)c1 to have a higher LogP value.,CCc1cccc(NC(=O)C(=O)N[C@@H](Cn2cncn2)c2ccccc2)c1,2.3366999999999996
234678,Modify the molecule C[C@@H](CCC(C)(C)C)NC(=O)NC[C@H]1CCC[NH+](C)C1 to have a higher LogP value.,C[C@@H](CCC(C)(C)C)NC(=O)NC[C@H]1CCC[NH+](C)C1,1.4251000000000016
2715,Optimize the molecule C[C@@H](C[NH2+]Cc1cc[nH]c1)c1ccc(F)c(F)c1 to have a higher LogP value.,C[C@@H](C[NH2+]Cc1cc[nH]c1)c1ccc(F)c(F)c1,2.1599999999999993
177106,Modify the molecule CCc1nnsc1C(=O)N1CCC[NH+](Cc2ccccc2C)CC1 to increase its LogP value.,CCc1nnsc1C(=O)N1CCC[NH+](Cc2ccccc2C)CC1,1.3399199999999998
249376,Modify the molecule CC(C)C[NH+](C1CC1)[C@H]1CCC(C)(C)[C@@H]1O to have a lower LogP value.,CC(C)C[NH+](C1CC1)[C@H]1CCC(C)(C)[C@@H]1O,1.2391999999999994
90210,Please modify the molecule Cc1nc(-c2cccnc2)sc1[C@H](C)[NH2+]CC1(C2CC2)CCC1 to decrease its LogP value.,Cc1nc(-c2cccnc2)sc1[C@H](C)[NH2+]CC1(C2CC2)CCC1,3.718220000000003
225729,Please modify the molecule CCOC[C@H]1CCN(C(=O)C[C@H]2c3ccccc3C=CN2C(C)=O)C1 to increase its LogP value.,CCOC[C@H]1CCN(C(=O)C[C@H]2c3ccccc3C=CN2C(C)=O)C1,2.8356000000000012
204644,Modify the molecule NC(=S)N1N=C(c2ccccc2Cl)C[C@H]1c1cccs1 to decrease its LogP value.,NC(=S)N1N=C(c2ccccc2Cl)C[C@H]1c1cccs1,3.7962000000000016
163744,Please optimize the molecule C[C@H]1OCC[C@@H]1C(=O)OCc1ccc([N+](=O)[O-])cc1Br to have a higher LogP value.,C[C@H]1OCC[C@@H]1C(=O)OCc1ccc([N+](=O)[O-])cc1Br,2.8255000000000017
72865,Modify the molecule CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1 to increase its LogP value.,CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1,4.299720000000003
9715,Modify the molecule Cc1cnc2c(c1)nc(CCl)n2[C@@H]1CCCC[C@@H]1C to decrease its LogP value.,Cc1cnc2c(c1)nc(CCl)n2[C@@H]1CCCC[C@@H]1C,4.229720000000003
28815,Modify the molecule CC(=O)N1CCN(c2cc(CC[C@H]3CCC[NH2+]3)ncn2)CC1 to have a lower LogP value.,CC(=O)N1CCN(c2cc(CC[C@H]3CCC[NH2+]3)ncn2)CC1,-0.19649999999999768
109512,Modify the molecule CC[NH2+][C@H]1CCCC[C@@H](Cc2ccc(O)cc2)C1 to have a higher LogP value.,CC[NH2+][C@H]1CCCC[C@@H](Cc2ccc(O)cc2)C1,2.4669
99613,Optimize the molecule O=C(Nc1nc2c(s1)CCC[C@@H]2C(=O)Nc1cc2ccccc2oc1=O)c1ccc(Cl)cc1 to have a higher LogP value.,O=C(Nc1nc2c(s1)CCC[C@@H]2C(=O)Nc1cc2ccccc2oc1=O)c1ccc(Cl)cc1,5.2138000000000035
20766,Please modify the molecule Cc1cc([O-])nc(SCC(=O)N[C@H]2N=C3CCCC[C@@H]3S2)n1 to increase its LogP value.,Cc1cc([O-])nc(SCC(=O)N[C@H]2N=C3CCCC[C@@H]3S2)n1,1.4809199999999998
33466,Modify the molecule COc1cccc(C(=O)O[C@@H](C)C(=O)NC(=O)NC2CC2)c1O to have a lower LogP value.,COc1cccc(C(=O)O[C@@H](C)C(=O)NC(=O)NC2CC2)c1O,0.9342999999999997
230283,Please optimize the molecule Cc1ccccc1OCC(=O)N[C@@H]1C[C@H](C)N(c2ccccc2)C1 to have a lower LogP value.,Cc1ccccc1OCC(=O)N[C@@H]1C[C@H](C)N(c2ccccc2)C1,3.157420000000002
205457,Please modify the molecule CCCCN(C)[C@]1(C[NH3+])CSCCC1(C)C to decrease its LogP value.,CCCCN(C)[C@]1(C[NH3+])CSCCC1(C)C,1.8620999999999996
8116,Modify the molecule Cc1cccc(NC(=O)N[C@@H]2CCC[NH+](C)C2)c1Cl to increase its LogP value.,Cc1cccc(NC(=O)N[C@@H]2CCC[NH+](C)C2)c1Cl,1.4470200000000002
156827,Modify the molecule Cc1nn(C)c(Cl)c1CNC[C@@H](c1ccc(F)cc1)N1CCOCC1 to have a higher LogP value.,Cc1nn(C)c(Cl)c1CNC[C@@H](c1ccc(F)cc1)N1CCOCC1,2.684120000000001
63522,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(O)c(Cl)c2)CC1 to have a lower LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(O)c(Cl)c2)CC1,3.536500000000002
62023,Please optimize the molecule C[C@@H]1C[C@@H](C)CN(c2cc(SCC(=O)Nc3ccccc3Br)ncn2)C1 to have a lower LogP value.,C[C@@H]1C[C@@H](C)CN(c2cc(SCC(=O)Nc3ccccc3Br)ncn2)C1,4.452200000000003
217424,Please modify the molecule CC[C@H](C)NC(=O)[C@@H](C)NC(=O)N[C@@H]1C[C@@H]1c1ccccc1 to decrease its LogP value.,CC[C@H](C)NC(=O)[C@@H](C)NC(=O)N[C@@H]1C[C@@H]1c1ccccc1,2.1449
54265,Modify the molecule CCOc1ccc([C@@H](C[NH3+])N2CCC(CC)(CC)C2)cc1 to have a lower LogP value.,CCOc1ccc([C@@H](C[NH3+])N2CCC(CC)(CC)C2)cc1,2.8804000000000007
198333,Please modify the molecule CS(=O)(=O)N1CCC[C@H](CCc2cccc(C(F)(F)F)c2)C1 to decrease its LogP value.,CS(=O)(=O)N1CCC[C@H](CCc2cccc(C(F)(F)F)c2)C1,3.3096000000000023
60757,Optimize the molecule O=C(Cn1nc(-c2ccccc2)ccc1=O)Nc1cccc2cnccc12 to have a lower LogP value.,O=C(Cn1nc(-c2ccccc2)ccc1=O)Nc1cccc2cnccc12,3.097200000000001
117497,Modify the molecule CS(=O)(=O)N1CCCc2cc([C@@H](O)C[NH+]3CCC(C(F)(F)F)CC3)ccc21 to have a lower LogP value.,CS(=O)(=O)N1CCCc2cc([C@@H](O)C[NH+]3CCC(C(F)(F)F)CC3)ccc21,1.2893999999999997
139835,Modify the molecule CO[C@@H]1C[C@@H](C(=O)[O-])N(C(=O)CSc2cccs2)C1 to have a lower LogP value.,CO[C@@H]1C[C@@H](C(=O)[O-])N(C(=O)CSc2cccs2)C1,0.2060000000000004
215533,Please optimize the molecule CCOc1cccc(CC(=O)NCc2cn(C)nc2CC)c1 to have a higher LogP value.,CCOc1cccc(CC(=O)NCc2cn(C)nc2CC)c1,2.2401
116876,Modify the molecule O=C(NNC(=O)Nc1cccc(F)c1)Nc1ccc(OC(F)F)cc1 to decrease its LogP value.,O=C(NNC(=O)Nc1cccc(F)c1)Nc1ccc(OC(F)F)cc1,3.285300000000001
102902,Please optimize the molecule Cc1occc1-c1nnc(SCc2coc(-c3ccccc3)n2)n1C to have a lower LogP value.,Cc1occc1-c1nnc(SCc2coc(-c3ccccc3)n2)n1C,4.330820000000004
82792,Optimize the molecule CCOc1ccccc1NC(=O)C[C@H]1C(=O)Nc2nc(-c3ccccc3)nn21 to have a higher LogP value.,CCOc1ccccc1NC(=O)C[C@H]1C(=O)Nc2nc(-c3ccccc3)nn21,2.865800000000001
128705,Modify the molecule Cc1cccc(-c2cc(=O)[nH]c(Nc3cc(F)c(F)c(F)c3)n2)c1 to increase its LogP value.,Cc1cccc(-c2cc(=O)[nH]c(Nc3cc(F)c(F)c(F)c3)n2)c1,3.906220000000002
121620,Optimize the molecule Cn1c(SCc2ccc3c(c2)OCO3)nc2c(sc(=S)n2-c2ccc(Cl)cc2)c1=O to have a lower LogP value.,Cn1c(SCc2ccc3c(c2)OCO3)nc2c(sc(=S)n2-c2ccc(Cl)cc2)c1=O,5.1895900000000035
81472,Optimize the molecule NC(=O)CN1CCN(C(=O)[C@H]2CCCO[C@H]2c2ccccc2)CC1 to have a lower LogP value.,NC(=O)CN1CCN(C(=O)[C@H]2CCCO[C@H]2c2ccccc2)CC1,0.7838000000000005
106429,Modify the molecule CC[C@@H](C)CN(CC)C(=O)[C@@H]1CC[C@H](C[NH3+])O1 to increase its LogP value.,CC[C@@H](C)CN(CC)C(=O)[C@@H]1CC[C@H](C[NH3+])O1,0.6705000000000014
229964,Please modify the molecule Cc1ccc(C[NH+](C)[C@H]2CCC[C@@H]2S(C)(=O)=O)cc1F to increase its LogP value.,Cc1ccc(C[NH+](C)[C@H]2CCC[C@@H]2S(C)(=O)=O)cc1F,1.1145200000000002
164634,Please modify the molecule CCc1onc(C)c1NC(=O)N1CCN([C@H](C)CC(=O)OC)CC1 to decrease its LogP value.,CCc1onc(C)c1NC(=O)N1CCN([C@H](C)CC(=O)OC)CC1,1.6465199999999998
145875,Please modify the molecule CSCC[C@](C)(O)CNC(=O)Cc1ccccc1Cl to increase its LogP value.,CSCC[C@](C)(O)CNC(=O)Cc1ccccc1Cl,2.5028000000000006
243261,Please modify the molecule Cc1cc(C(=O)NCC(=O)N(C)Cc2ccco2)nn1C to increase its LogP value.,Cc1cc(C(=O)NCC(=O)N(C)Cc2ccco2)nn1C,0.7099199999999994
95996,Please optimize the molecule Cc1cc(C(=O)OCC(=O)N[C@H]2CCCC[C@H]2C)c(C)o1 to have a higher LogP value.,Cc1cc(C(=O)OCC(=O)N[C@H]2CCCC[C@H]2C)c(C)o1,2.748140000000001
34568,Modify the molecule CCCn1c(SCC(=O)N(C)C2(C#N)CCCCC2)nc2ccccc2c1=O to decrease its LogP value.,CCCn1c(SCC(=O)N(C)C2(C#N)CCCCC2)nc2ccccc2c1=O,3.5834800000000024
139771,Modify the molecule COc1ccc(F)c(NC(=O)CSc2nnnn2C2CC2)c1 to increase its LogP value.,COc1ccc(F)c(NC(=O)CSc2nnnn2C2CC2)c1,1.8864999999999998
206794,Please optimize the molecule CC1=Nc2ncnn2C(=O)[C@@H]1CCC(=O)N[C@H](C)c1ccccc1 to have a lower LogP value.,CC1=Nc2ncnn2C(=O)[C@@H]1CCC(=O)N[C@H](C)c1ccccc1,2.2981000000000007
168692,Modify the molecule CC[C@@H](NC(=O)N(C)C[C@H](O)C1CC1)c1ccc(C)c(F)c1 to increase its LogP value.,CC[C@@H](NC(=O)N(C)C[C@H](O)C1CC1)c1ccc(C)c(F)c1,2.9975200000000015
213483,Please optimize the molecule CC(=O)Oc1ccc(/C=C2/N=C(c3cccc(Cl)c3Cl)OC2=O)cc1OC(C)=O to have a lower LogP value.,CC(=O)Oc1ccc(/C=C2/N=C(c3cccc(Cl)c3Cl)OC2=O)cc1OC(C)=O,4.188500000000002
124059,Optimize the molecule CCCc1cc(NC(=O)NC(C)(C)c2ccc(F)c(F)c2)n(C)n1 to have a higher LogP value.,CCCc1cc(NC(=O)NC(C)(C)c2ccc(F)c(F)c2)n(C)n1,3.707600000000002
153416,Modify the molecule CCOC(=O)[C@H]1C(=O)N(Cc2ccccc2)c2nc3ccccc3n2[C@@H]1c1ccccc1F to decrease its LogP value.,CCOC(=O)[C@H]1C(=O)N(Cc2ccccc2)c2nc3ccccc3n2[C@@H]1c1ccccc1F,4.4909000000000034
120031,Please optimize the molecule CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1 to have a higher LogP value.,CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1,0.23549999999999982
137325,Modify the molecule C[C@H](NC(=O)NCCOCC(F)(F)F)c1ccc(Cl)s1 to have a higher LogP value.,C[C@H](NC(=O)NCCOCC(F)(F)F)c1ccc(Cl)s1,3.340600000000001
243076,Modify the molecule COc1cccc(N2CCN(c3ccc(C(C)=O)cc3[N+](=O)[O-])CC2)c1 to increase its LogP value.,COc1cccc(N2CCN(c3ccc(C(C)=O)cc3[N+](=O)[O-])CC2)c1,3.132600000000002
127807,Modify the molecule COc1ccc(C)cc1NC(=O)c1nnn(-c2ccc(F)cc2)n1 to have a higher LogP value.,COc1ccc(C)cc1NC(=O)c1nnn(-c2ccc(F)cc2)n1,2.3707200000000004
212132,Modify the molecule C[C@H](NC(=O)[C@H](C)N1C(=O)[C@H]2CCCC[C@@H]2C1=O)c1ccc(F)c(F)c1 to increase its LogP value.,C[C@H](NC(=O)[C@H](C)N1C(=O)[C@H]2CCCC[C@@H]2C1=O)c1ccc(F)c(F)c1,2.7057
238845,Modify the molecule CNC(=O)[C@H]1CCCCN1C(=O)c1cccc(F)c1 to increase its LogP value.,CNC(=O)[C@H]1CCCCN1C(=O)c1cccc(F)c1,1.5663999999999991
9826,Modify the molecule Cc1cc(C)cc(Oc2cc(N3C(=O)[C@H]4[C@@H]5CC[C@@H](O5)[C@@H]4C3=O)cc([N+](=O)[O-])c2)c1 to have a lower LogP value.,Cc1cc(C)cc(Oc2cc(N3C(=O)[C@H]4[C@@H]5CC[C@@H](O5)[C@@H]4C3=O)cc([N+](=O)[O-])c2)c1,3.670740000000002
127159,Modify the molecule Cc1nc(-c2cccc(CNC(=O)c3ccc[n+]([O-])c3)c2)n[nH]1 to decrease its LogP value.,Cc1nc(-c2cccc(CNC(=O)c3ccc[n+]([O-])c3)c2)n[nH]1,1.3435199999999998
100991,Modify the molecule O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(C(=O)[C@H]2CCS(=O)(=O)C2)CC1 to increase its LogP value.,O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(C(=O)[C@H]2CCS(=O)(=O)C2)CC1,-0.221799999999998
183628,Please optimize the molecule O=C(CCSc1ncc(-c2ccc(F)cc2)o1)Nc1ccccc1F to have a lower LogP value.,O=C(CCSc1ncc(-c2ccc(F)cc2)o1)Nc1ccccc1F,4.740700000000003
19946,Please optimize the molecule CCc1nsc(NCC(=O)NC(C)(C)C)n1 to have a higher LogP value.,CCc1nsc(NCC(=O)NC(C)(C)C)n1,1.4271
10728,Optimize the molecule CCc1oc2ccccc2c1/C=C/C(=O)N(C)C1CC[NH+](C)CC1 to have a lower LogP value.,CCc1oc2ccccc2c1/C=C/C(=O)N(C)C1CC[NH+](C)CC1,2.1439000000000004
245108,Modify the molecule Cc1n[nH]c2cc(NC(=O)[C@@H](C)NC(=O)C3CCCCC3)ccc12 to have a higher LogP value.,Cc1n[nH]c2cc(NC(=O)[C@@H](C)NC(=O)C3CCCCC3)ccc12,2.894820000000001
60400,Optimize the molecule C[NH+]1CCN(c2ccc(NC(=O)C(C)(C)c3cccc(C#N)c3)cc2)CC1 to have a higher LogP value.,C[NH+]1CCN(c2ccc(NC(=O)C(C)(C)c3cccc(C#N)c3)cc2)CC1,1.80928
142900,Please optimize the molecule CC[C@H](C)CN(CC)C(=O)[C@H]1CCC[C@H]([NH3+])[C@@H]1C to have a higher LogP value.,CC[C@H](C)CN(CC)C(=O)[C@H]1CCC[C@H]([NH3+])[C@@H]1C,1.9277
38090,Modify the molecule CC[C@H]1C(=O)NCC[NH+]1CC(=O)Nc1cc(Cl)ccc1F to decrease its LogP value.,CC[C@H]1C(=O)NCC[NH+]1CC(=O)Nc1cc(Cl)ccc1F,0.21090000000000125
187679,Modify the molecule CC[NH2+][C@@]1(C(N)=O)CCC[C@H](N(C)[C@@H]2CCS(=O)(=O)C2)C1 to increase its LogP value.,CC[NH2+][C@@]1(C(N)=O)CCC[C@H](N(C)[C@@H]2CCS(=O)(=O)C2)C1,-1.1446999999999965
165308,Modify the molecule COc1ccc(/C=C/C(=O)Nc2cc(C)cc(C)c2)cc1S(=O)(=O)NC(C)C to decrease its LogP value.,COc1ccc(/C=C/C(=O)Nc2cc(C)cc(C)c2)cc1S(=O)(=O)NC(C)C,3.650640000000002
123140,Please modify the molecule CCn1c(CNC(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)n[nH]c1=S to decrease its LogP value.,CCn1c(CNC(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)n[nH]c1=S,2.724050000000001
179069,Modify the molecule C[C@H](NC(=O)CN1CC[NH+](C)C[C@@H]1C)c1ccc(Cl)cc1Cl to increase its LogP value.,C[C@H](NC(=O)CN1CC[NH+](C)C[C@@H]1C)c1ccc(Cl)cc1Cl,1.3894000000000009
199008,Modify the molecule COc1cccc(Cn2cc(C(F)(F)F)ccc2=O)c1 to have a higher LogP value.,COc1cccc(Cn2cc(C(F)(F)F)ccc2=O)c1,2.9240000000000013
16019,Modify the molecule C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)C(=O)NNC(=O)c1ccco1 to increase its LogP value.,C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)C(=O)NNC(=O)c1ccco1,1.4264000000000001
112003,Please modify the molecule CC(=O)Nc1ccc(NC(=O)CCc2cnn(-c3ccccc3)c2)cc1 to increase its LogP value.,CC(=O)Nc1ccc(NC(=O)CCc2cnn(-c3ccccc3)c2)cc1,3.402000000000002
221025,Modify the molecule CC(C)[NH2+]C[C@@H](Cc1cccc(Cl)c1)Cc1nccs1 to decrease its LogP value.,CC(C)[NH2+]C[C@@H](Cc1cccc(Cl)c1)Cc1nccs1,3.1697000000000015
181692,Modify the molecule COc1cccc(N2CC[C@@H](CNC(=O)N3CCCC[C@@H]3C)C2)c1 to increase its LogP value.,COc1cccc(N2CC[C@@H](CNC(=O)N3CCCC[C@@H]3C)C2)c1,3.105500000000002
213877,Modify the molecule COc1ccc(Br)cc1CNC(=O)c1cccc2cc[nH]c12 to have a lower LogP value.,COc1ccc(Br)cc1CNC(=O)c1cccc2cc[nH]c12,3.8690000000000015
190062,Please optimize the molecule CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2cccnc2Cl)c1 to have a higher LogP value.,CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2cccnc2Cl)c1,4.263200000000003
94557,Please modify the molecule Cc1nnnn1-c1ccc(F)c(NC(=O)c2cccc3c2OCO3)c1 to decrease its LogP value.,Cc1nnnn1-c1ccc(F)c(NC(=O)c2cccc3c2OCO3)c1,2.09082
233836,Please optimize the molecule COc1ccc2c(CC(=O)Nc3cccc(S(=O)(=O)N4CCCC4)c3)coc2c1 to have a higher LogP value.,COc1ccc2c(CC(=O)Nc3cccc(S(=O)(=O)N4CCCC4)c3)coc2c1,3.4071000000000025
112894,Optimize the molecule CC[C@@H](C)Oc1cccc(NC(=O)C[NH+](C)C)c1 to have a lower LogP value.,CC[C@@H](C)Oc1cccc(NC(=O)C[NH+](C)C)c1,0.9469000000000002
157649,Modify the molecule CNC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cc(F)ccc2F)CC1 to decrease its LogP value.,CNC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cc(F)ccc2F)CC1,0.3327000000000009
225024,Please modify the molecule Cc1ccc(-c2noc3ncnc(N4CCC(C(=O)NC(C)C)CC4)c23)cc1 to increase its LogP value.,Cc1ccc(-c2noc3ncnc(N4CCC(C(=O)NC(C)C)CC4)c23)cc1,3.334220000000002
22381,Modify the molecule COc1ccc(N2C[C@@H](C(=O)Nc3cccc(C(C)=O)c3)CC2=O)cc1 to decrease its LogP value.,COc1ccc(N2C[C@@H](C(=O)Nc3cccc(C(C)=O)c3)CC2=O)cc1,2.889400000000001
242935,Please modify the molecule CCCc1cc(C(=O)NCc2ccncc2)n(C)n1 to increase its LogP value.,CCCc1cc(C(=O)NCc2ccncc2)n(C)n1,1.6976
94716,Please modify the molecule CO[C@@]1(C)C[C@H](N(C)C(=O)CCCn2cncn2)C1(C)C to increase its LogP value.,CO[C@@]1(C)C[C@H](N(C)C(=O)CCCn2cncn2)C1(C)C,1.720299999999999
216419,Please modify the molecule O=C(NC[C@H](O)COc1ccc(F)cc1)c1cnc([C@H]2CCCO2)s1 to decrease its LogP value.,O=C(NC[C@H](O)COc1ccc(F)cc1)c1cnc([C@H]2CCCO2)s1,2.3034
139464,Please optimize the molecule O=C(CCc1cc(Cl)no1)N1[C@H]2CC[C@@H]1Cn1c(nc3ccccc3c1=O)C2 to have a higher LogP value.,O=C(CCc1cc(Cl)no1)N1[C@H]2CC[C@@H]1Cn1c(nc3ccccc3c1=O)C2,2.5864000000000003
150469,Please optimize the molecule Cc1ccc2ncc(C[NH+]3CCCC[C@@H]3c3cccn3C)n2c1 to have a higher LogP value.,Cc1ccc2ncc(C[NH+]3CCCC[C@@H]3c3cccn3C)n2c1,2.29132
122078,Optimize the molecule CC(C)(C)Oc1cc(C(=O)N2CCO[C@@H](c3ccccc3Cl)C2)ccn1 to have a lower LogP value.,CC(C)(C)Oc1cc(C(=O)N2CCO[C@@H](c3ccccc3Cl)C2)ccn1,4.126000000000003
46099,Please modify the molecule CN(C)S(=O)(=O)c1ccc(/C=C/C(=O)OCc2ccccc2)cc1 to decrease its LogP value.,CN(C)S(=O)(=O)c1ccc(/C=C/C(=O)OCc2ccccc2)cc1,2.693500000000001
63154,Modify the molecule CC(=O)Nc1ccc2nc(NC(=O)C3(c4ccc(Br)cc4)CC3)sc2c1 to decrease its LogP value.,CC(=O)Nc1ccc2nc(NC(=O)C3(c4ccc(Br)cc4)CC3)sc2c1,4.687500000000003
99129,Optimize the molecule CN(CCOc1ccccc1F)C(=O)CCC1CCCCC1 to have a lower LogP value.,CN(CCOc1ccccc1F)C(=O)CCC1CCCCC1,4.023400000000003
58108,Modify the molecule Cc1cc(N2CCO[C@@H](c3ccc(F)cc3)C2)ncc1[N+](=O)[O-] to have a lower LogP value.,Cc1cc(N2CCO[C@@H](c3ccc(F)cc3)C2)ncc1[N+](=O)[O-],3.015220000000002
165992,Please modify the molecule C=CCn1nc2c(C)c(C)nc(-c3cccnc3)n2c1=O to decrease its LogP value.,C=CCn1nc2c(C)c(C)nc(-c3cccnc3)n2c1=O,1.7558399999999996
8312,Optimize the molecule O=C(OCC(=O)N1CCO[C@H]2CCCC[C@H]21)c1ccc(CO)cc1 to have a lower LogP value.,O=C(OCC(=O)N1CCO[C@H]2CCCC[C@H]21)c1ccc(CO)cc1,1.5056999999999992
37312,Modify the molecule O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F to have a higher LogP value.,O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F,1.7683999999999997
85020,Optimize the molecule C[C@H](C#N)Oc1ccc(C[NH+](C)CCC2CC2)cc1 to have a lower LogP value.,C[C@H](C#N)Oc1ccc(C[NH+](C)CCC2CC2)cc1,1.7922799999999994
32051,Modify the molecule O=C(Cc1c(F)cccc1Cl)/N=C1/NCCS1 to decrease its LogP value.,O=C(Cc1c(F)cccc1Cl)/N=C1/NCCS1,2.2405999999999997
88382,Optimize the molecule Cc1nc(N2CCN(Cc3c(C)nc4sc(C)cn34)CC2)c2cnn(C)c2n1 to have a lower LogP value.,Cc1nc(N2CCN(Cc3c(C)nc4sc(C)cn34)CC2)c2cnn(C)c2n1,2.31996
55387,Optimize the molecule COCc1cccc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)c1 to have a higher LogP value.,COCc1cccc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)c1,3.0955200000000014
106049,Optimize the molecule COc1ccc(NC(=O)N2CCNC(=O)C2)cc1Cc1ccccc1 to have a higher LogP value.,COc1ccc(NC(=O)N2CCNC(=O)C2)cc1Cc1ccccc1,2.2497
25581,Modify the molecule O=C1c2ccccc2N[C@H](c2ccc(O)c([N+](=O)[O-])c2)N1c1ccncc1 to have a higher LogP value.,O=C1c2ccccc2N[C@H](c2ccc(O)c([N+](=O)[O-])c2)N1c1ccncc1,3.4665000000000017
147985,Modify the molecule Cc1ccc(-n2nnc(-c3nsc(NC(=O)c4ccc(C(C)(C)C)cc4)n3)c2C)cc1 to have a higher LogP value.,Cc1ccc(-n2nnc(-c3nsc(NC(=O)c4ccc(C(C)(C)C)cc4)n3)c2C)cc1,4.952440000000004
29924,Optimize the molecule Cc1csc([C@@H](C)NC(=O)CCCO)n1 to have a higher LogP value.,Cc1csc([C@@H](C)NC(=O)CCCO)n1,1.40122
247106,Modify the molecule O=C([O-])[C@@H](Cc1ccccc1)[P@@](=O)([O-])C[NH+]1CCOCC1 to have a higher LogP value.,O=C([O-])[C@@H](Cc1ccccc1)[P@@](=O)([O-])C[NH+]1CCOCC1,-2.1413999999999964
108131,Modify the molecule CN(C)[C@@H](C(=O)N1CCC(N2CCOC2=O)CC1)c1ccccc1F to have a higher LogP value.,CN(C)[C@@H](C(=O)N1CCC(N2CCOC2=O)CC1)c1ccccc1F,1.8715999999999995
183815,Please optimize the molecule CCc1ccc(-c2nc(CC(=O)N(C)[C@@H](C)c3sc(C)nc3C)cs2)cc1 to have a higher LogP value.,CCc1ccc(-c2nc(CC(=O)N(C)[C@@H](C)c3sc(C)nc3C)cs2)cc1,5.207940000000005
222945,Please optimize the molecule CCN1CCO[C@@H](CNc2cc(C(F)(F)F)ccc2Cl)C1 to have a higher LogP value.,CCN1CCO[C@@H](CNc2cc(C(F)(F)F)ccc2Cl)C1,3.4914000000000023
183760,Optimize the molecule CCn1nc(C)c(NC(=O)N2CCO[C@H](c3ccccc3F)C2)c1C to have a lower LogP value.,CCn1nc(C)c(NC(=O)N2CCO[C@H](c3ccccc3F)C2)c1C,3.2643400000000025
83644,Optimize the molecule Cc1noc(C)c1C[NH+]1C[C@@H]2CC[C@H](C1)N(C(=O)c1ccoc1)C2 to have a higher LogP value.,Cc1noc(C)c1C[NH+]1C[C@@H]2CC[C@H](C1)N(C(=O)c1ccoc1)C2,1.2039399999999993
50969,Modify the molecule C[C@H](CC1CCCC1)C(=O)NCCc1nc2ccccc2s1 to decrease its LogP value.,C[C@H](CC1CCCC1)C(=O)NCCc1nc2ccccc2s1,4.171400000000003
191407,Optimize the molecule Nc1nc(N2CC(=O)N(CCc3ccccc3)C(=O)C2)ncc1C(=O)NCc1ccccc1 to have a higher LogP value.,Nc1nc(N2CC(=O)N(CCc3ccccc3)C(=O)C2)ncc1C(=O)NCc1ccccc1,1.4066999999999987
207869,Optimize the molecule COC(=O)CN1C(=O)c2ccccc2O[C@@H]1c1ccc(OC)cc1 to have a higher LogP value.,COC(=O)CN1C(=O)c2ccccc2O[C@@H]1c1ccc(OC)cc1,2.4016
25812,Modify the molecule COc1ccc(Cc2noc([C@H]3CC[NH2+][C@H]3C)n2)cn1 to have a lower LogP value.,COc1ccc(Cc2noc([C@H]3CC[NH2+][C@H]3C)n2)cn1,0.5032
84278,Modify the molecule C/C(=N/N=C1/NC(=O)[C@@H](CC(=O)Nc2ccccc2C)S1)c1ccc([N+](=O)[O-])cc1 to have a lower LogP value.,C/C(=N/N=C1/NC(=O)[C@@H](CC(=O)Nc2ccccc2C)S1)c1ccc([N+](=O)[O-])cc1,3.2436200000000017
207691,Modify the molecule CN(CC1CC1)C(=O)[C@H]1CC(=O)N(C)[C@H]1c1cccnc1 to have a higher LogP value.,CN(CC1CC1)C(=O)[C@H]1CC(=O)N(C)[C@H]1c1cccnc1,1.4693999999999994
134820,Please optimize the molecule O=C(Nc1ccc(Cl)cc1)c1ccc(-n2cccn2)c([N+](=O)[O-])c1 to have a lower LogP value.,O=C(Nc1ccc(Cl)cc1)c1ccc(-n2cccn2)c([N+](=O)[O-])c1,3.686200000000002
153394,Please optimize the molecule C=CCNC(=O)NC(=O)[C@H](C)Nc1ccc(CC(=O)NC)cc1 to have a higher LogP value.,C=CCNC(=O)NC(=O)[C@H](C)Nc1ccc(CC(=O)NC)cc1,0.7873000000000001
217731,Please modify the molecule N#Cc1csc(C(=O)Nc2ccc(O[C@@H]3CCOC3)cc2)c1 to increase its LogP value.,N#Cc1csc(C(=O)Nc2ccc(O[C@@H]3CCOC3)cc2)c1,3.0397800000000013
109634,Modify the molecule CC(C)(C(=O)N1CC[NH+](C2CC2)CC1)c1cccc(C#N)c1 to decrease its LogP value.,CC(C)(C(=O)N1CC[NH+](C2CC2)CC1)c1cccc(C#N)c1,0.725380000000001
84261,Modify the molecule Cc1ccc([C@@H]2CC(=O)C[C@H](c3ccc(C)cc3)[NH2+]2)cc1 to have a lower LogP value.,Cc1ccc([C@@H]2CC(=O)C[C@H](c3ccc(C)cc3)[NH2+]2)cc1,3.0121400000000005
75148,Optimize the molecule C[C@@H](C[NH3+])CN1CC[NH+](Cc2cn3ccccc3n2)CC1 to have a higher LogP value.,C[C@@H](C[NH3+])CN1CC[NH+](Cc2cn3ccccc3n2)CC1,-1.0871999999999966
106749,Optimize the molecule Cc1ccc(CC(=O)N(C)C2CCN(c3cccc(F)c3)CC2)cn1 to have a higher LogP value.,Cc1ccc(CC(=O)N(C)C2CCN(c3cccc(F)c3)CC2)cn1,3.1990200000000018
68483,Please optimize the molecule O=C(NCC1CCCCC1)[C@@H]1CCCN1C(=O)c1cc2scnc2[nH]1 to have a lower LogP value.,O=C(NCC1CCCCC1)[C@@H]1CCCN1C(=O)c1cc2scnc2[nH]1,2.9255000000000004
105728,Please optimize the molecule CCOC(=O)c1cccc(NC(=O)c2cc(-c3cccnc3)n(-c3ccccc3)n2)c1 to have a lower LogP value.,CCOC(=O)c1cccc(NC(=O)c2cc(-c3cccnc3)n(-c3ccccc3)n2)c1,4.363300000000002
100360,Please optimize the molecule COc1ccc(C[NH2+][C@H](C)c2cccc3ccccc23)cc1O to have a higher LogP value.,COc1ccc(C[NH2+][C@H](C)c2cccc3ccccc23)cc1O,3.378600000000002
186681,Modify the molecule CCc1ccccc1NC(=O)[C@@H]1CC(=O)NC2=NC(SC)=NC(=O)[C@@H]21 to have a lower LogP value.,CCc1ccccc1NC(=O)[C@@H]1CC(=O)NC2=NC(SC)=NC(=O)[C@@H]21,1.5974999999999997
77877,Modify the molecule CSC[C@@H](C)NC(=O)[C@@H]1CCC(=O)N1Cc1ccc(C)cc1 to decrease its LogP value.,CSC[C@@H](C)NC(=O)[C@@H]1CCC(=O)N1Cc1ccc(C)cc1,2.35372
108602,Modify the molecule C[C@@H](CC#N)N(C)c1c(F)c(F)nc(F)c1F to decrease its LogP value.,C[C@@H](CC#N)N(C)c1c(F)c(F)nc(F)c1F,2.37638
22795,Modify the molecule CNS(=O)(=O)c1cccc(NC(=O)/C=C(/C)C(C)(C)C)c1 to have a higher LogP value.,CNS(=O)(=O)c1cccc(NC(=O)/C=C(/C)C(C)(C)C)c1,2.5256000000000007
103912,Modify the molecule C[C@H](c1ccncc1)[NH+]1[C@H]2CC[C@@H]1CC(CC(=O)[O-])C2 to have a higher LogP value.,C[C@H](c1ccncc1)[NH+]1[C@H]2CC[C@@H]1CC(CC(=O)[O-])C2,0.10850000000000026
153345,Please modify the molecule O=C1CC[C@H](NC(=O)CCSc2ccnc3cc(Cl)ccc23)CN1 to increase its LogP value.,O=C1CC[C@H](NC(=O)CCSc2ccnc3cc(Cl)ccc23)CN1,2.765200000000001
64134,Modify the molecule CC(C)(C)[NH2+]Cc1ccn(Cc2cc(F)cc(Br)c2)n1 to increase its LogP value.,CC(C)(C)[NH2+]Cc1ccn(Cc2cc(F)cc(Br)c2)n1,2.6949000000000005
208356,Optimize the molecule Cc1ccc(NC(=O)NC2CC[NH+](C)CC2)s1 to have a higher LogP value.,Cc1ccc(NC(=O)NC2CC[NH+](C)CC2)s1,0.8551199999999997
35316,Modify the molecule COc1ccccc1CCN1Cc2cc(NC(=O)c3ccccc3OC)ccc2OCC1=O to have a higher LogP value.,COc1ccccc1CCN1Cc2cc(NC(=O)c3ccccc3OC)ccc2OCC1=O,3.919800000000002
154605,Please modify the molecule CC(C)Cc1ccc(CNc2cnn(-c3ncccn3)c2)cc1 to increase its LogP value.,CC(C)Cc1ccc(CNc2cnn(-c3ncccn3)c2)cc1,3.472900000000002
244409,Please optimize the molecule COc1ccc([C@H]2SCC(O)=Nc3n[nH]cc32)c(OC)c1 to have a lower LogP value.,COc1ccc([C@H]2SCC(O)=Nc3n[nH]cc32)c(OC)c1,2.8511000000000006
208342,Optimize the molecule O=C(CN1C(=O)NC2(CCCCC2)C1=O)Nc1ccc(N2CCCC2)cc1 to have a higher LogP value.,O=C(CN1C(=O)NC2(CCCCC2)C1=O)Nc1ccc(N2CCCC2)cc1,2.4799999999999995
55014,Modify the molecule CCN(CC#N)CCC(=O)NC1CCCCC1 to have a higher LogP value.,CCN(CC#N)CCC(=O)NC1CCCCC1,1.6708799999999995
50267,Please modify the molecule CN(C[C@H](O)C1CC1)C(=O)CN(C)c1ccccc1[N+](=O)[O-] to decrease its LogP value.,CN(C[C@H](O)C1CC1)C(=O)CN(C)c1ccccc1[N+](=O)[O-],1.2602999999999993
103464,Please optimize the molecule Cc1cc(NC(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c2ncccc2c1 to have a higher LogP value.,Cc1cc(NC(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c2ncccc2c1,3.478220000000002
56243,Modify the molecule C[C@@H](C(=O)NCC(=O)N1CCc2ccccc2C1)c1cccs1 to have a higher LogP value.,C[C@@H](C(=O)NCC(=O)N1CCc2ccccc2C1)c1cccs1,2.5527000000000006
88358,Optimize the molecule C[NH2+]Cc1ccc(-c2ccc(C)c(C)c2)c(C)c1 to have a higher LogP value.,C[NH2+]Cc1ccc(-c2ccc(C)c(C)c2)c(C)c1,2.9720600000000017
60274,Please modify the molecule CC(=O)c1cnc2nc(-c3ccncc3)nn2c1/C=C/N(C)C to increase its LogP value.,CC(=O)c1cnc2nc(-c3ccncc3)nn2c1/C=C/N(C)C,1.9212
178337,Optimize the molecule COc1ccc(N2CCn3c2nn(CC(=O)Nc2ccc(F)cc2F)c(=O)c3=O)cc1 to have a lower LogP value.,COc1ccc(N2CCn3c2nn(CC(=O)Nc2ccc(F)cc2F)c(=O)c3=O)cc1,1.4821999999999997
65443,Please optimize the molecule COc1ccc([C@H]2C(C(=O)Nc3cc(OC)c(Cl)cc3OC)=C(C)Nc3nnnn32)cc1 to have a lower LogP value.,COc1ccc([C@H]2C(C(=O)Nc3cc(OC)c(Cl)cc3OC)=C(C)Nc3nnnn32)cc1,3.2799000000000005
118088,Optimize the molecule C[C@@H](CNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1)[NH+](C)C1CC1 to have a higher LogP value.,C[C@@H](CNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1)[NH+](C)C1CC1,-0.029099999999999016
77991,Modify the molecule CC(C)n1c([C@H]2CCCN(C(=O)Nc3ccc(C(F)(F)F)cc3)C2)nn(C)c1=O to decrease its LogP value.,CC(C)n1c([C@H]2CCCN(C(=O)Nc3ccc(C(F)(F)F)cc3)C2)nn(C)c1=O,3.5930000000000017
10805,Please optimize the molecule Cc1ccc(C(=O)NCC(=O)N[C@@H](C)c2cccc(Cl)c2)cc1 to have a higher LogP value.,Cc1ccc(C(=O)NCC(=O)N[C@@H](C)c2cccc(Cl)c2)cc1,3.255620000000002
147383,Modify the molecule Cc1cc(C(=O)CN2CCOC[C@H]2C#N)c(C)n1CC(F)(F)F to decrease its LogP value.,Cc1cc(C(=O)CN2CCOC[C@H]2C#N)c(C)n1CC(F)(F)F,2.0743199999999997
163523,Please modify the molecule COc1ccc([C@@H]([NH2+]C[C@@H]2CC(=O)Nc3ccccc32)C(C)C)cc1 to increase its LogP value.,COc1ccc([C@@H]([NH2+]C[C@@H]2CC(=O)Nc3ccccc32)C(C)C)cc1,3.0817000000000014
103224,Optimize the molecule CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1 to have a lower LogP value.,CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1,3.3728000000000025
887,Please optimize the molecule O=C1CC[C@@H](NC(=O)COc2ccc(Cl)c(Cl)c2)CN1 to have a lower LogP value.,O=C1CC[C@@H](NC(=O)COc2ccc(Cl)c(Cl)c2)CN1,1.7669999999999997
207365,Please modify the molecule Cn1cnc(S(=O)(=O)NC2(c3ccc(Cl)cc3)CCOCC2)c1 to decrease its LogP value.,Cn1cnc(S(=O)(=O)NC2(c3ccc(Cl)cc3)CCOCC2)c1,2.0576999999999996
196436,Optimize the molecule Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCCO3)cc2)n1 to have a higher LogP value.,Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCCO3)cc2)n1,2.39794
205020,Optimize the molecule CCOc1ccc(S(=O)(=O)Nc2cccc(N3CCCCC3=O)c2)cc1F to have a higher LogP value.,CCOc1ccc(S(=O)(=O)Nc2cccc(N3CCCCC3=O)c2)cc1F,3.5421000000000022
111851,Please modify the molecule CCC[C@](O)(c1ccccc1)c1cc(C)cc(F)c1 to increase its LogP value.,CCC[C@](O)(c1ccccc1)c1cc(C)cc(F)c1,4.170120000000003
243557,Please modify the molecule C[C@@H](C1CC1)N(C)C(=O)c1csc(C#CCCO)c1 to increase its LogP value.,C[C@@H](C1CC1)N(C)C(=O)c1csc(C#CCCO)c1,2.352500000000001
213196,Modify the molecule CCOc1ccccc1OCCOCCOc1ccc([N+](=O)[O-])cc1 to have a higher LogP value.,CCOc1ccccc1OCCOCCOc1ccc([N+](=O)[O-])cc1,3.467900000000002
88486,Optimize the molecule Cc1nc([C@H](NC(=O)[C@H]2CSC(=O)N2)c2ccc(Cl)cc2)no1 to have a lower LogP value.,Cc1nc([C@H](NC(=O)[C@H]2CSC(=O)N2)c2ccc(Cl)cc2)no1,2.0620199999999995
158796,Please optimize the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(-c4nnco4)cc3)CC2)c(C)c1 to have a higher LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(-c4nnco4)cc3)CC2)c(C)c1,2.500140000000001
246191,Please optimize the molecule CCn1c(N2CCN(C(=O)c3ccc(F)cc3)CC2)nc2c(C)nn(C)c2c1=O to have a higher LogP value.,CCn1c(N2CCN(C(=O)c3ccc(F)cc3)CC2)nc2c(C)nn(C)c2c1=O,1.55982
230091,Modify the molecule CCCC(=O)N1CCC[C@H]1C(=O)N[C@H](C)c1cc(OC)c(OC)cc1F to have a lower LogP value.,CCCC(=O)N1CCC[C@H]1C(=O)N[C@H](C)c1cc(OC)c(OC)cc1F,2.8112000000000013
174656,Modify the molecule CC(C)[NH+]1C[C@H](C)[C@@H](NCc2ccc3c(c2)OCCCO3)C1 to increase its LogP value.,CC(C)[NH+]1C[C@H](C)[C@@H](NCc2ccc3c(c2)OCCCO3)C1,1.2491000000000005
159866,Modify the molecule CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1 to increase its LogP value.,CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1,3.842800000000003
24873,Please optimize the molecule Cc1cc(C(=O)N2CCC[C@@H]2[C@H]2CCC[C@@H]2O)ccc1F to have a higher LogP value.,Cc1cc(C(=O)N2CCC[C@@H]2[C@H]2CCC[C@@H]2O)ccc1F,2.899720000000001
51629,Modify the molecule C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1 to have a higher LogP value.,C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1,4.205200000000003
94669,Please optimize the molecule CC(C)NC(=O)N(C)C[C@@H]1CC(c2ccc(Cl)cc2)=NO1 to have a lower LogP value.,CC(C)NC(=O)N(C)C[C@@H]1CC(c2ccc(Cl)cc2)=NO1,2.8828000000000005
115615,Please optimize the molecule Cn1cc([C@H](O)CNC(=O)Nc2ccc(F)cc2OCC(F)F)cn1 to have a higher LogP value.,Cn1cc([C@H](O)CNC(=O)Nc2ccc(F)cc2OCC(F)F)cn1,2.0582
75955,Modify the molecule CC(C)CNC(=O)N1CCN(Cc2nc3cc(C(=O)NC(C)C)ccc3n2C)CC1 to decrease its LogP value.,CC(C)CNC(=O)N1CCN(Cc2nc3cc(C(=O)NC(C)C)ccc3n2C)CC1,2.194699999999999
132465,Please optimize the molecule COc1ccc(-c2noc([C@H]3CCCN(S(=O)(=O)c4cccc(F)c4)C3)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2noc([C@H]3CCCN(S(=O)(=O)c4cccc(F)c4)C3)n2)cc1OC,3.4612000000000025
108247,Modify the molecule OCc1ccc(-c2nccn2C2CC[NH+](C[C@@H]3CCCO3)CC2)o1 to decrease its LogP value.,OCc1ccc(-c2nccn2C2CC[NH+](C[C@@H]3CCCO3)CC2)o1,1.0341999999999996
140537,Please modify the molecule COC(=O)c1ccc(/C=N/NC(=O)c2nn(Cc3ccccc3)c(=O)c3ccccc23)cc1 to increase its LogP value.,COC(=O)c1ccc(/C=N/NC(=O)c2nn(Cc3ccccc3)c(=O)c3ccccc23)cc1,2.995300000000001
5973,Modify the molecule NC(=O)c1ccc(C(=O)Oc2cc(F)cc(Br)c2)cn1 to increase its LogP value.,NC(=O)c1ccc(C(=O)Oc2cc(F)cc(Br)c2)cn1,2.3013000000000003
7600,Modify the molecule O=C(OCc1ccccn1)c1ccc(COc2ccccc2Cl)o1 to have a lower LogP value.,O=C(OCc1ccccn1)c1ccc(COc2ccccc2Cl)o1,4.264000000000003
163762,Modify the molecule COc1ccc(N2C[C@H](C(=O)Nc3n[nH]c(-c4ccccc4OC)n3)CC2=O)cc1 to have a lower LogP value.,COc1ccc(N2C[C@H](C(=O)Nc3n[nH]c(-c4ccccc4OC)n3)CC2=O)cc1,2.4805
245477,Modify the molecule CS[C@H](C)c1cccc(NC(=O)[C@H]2CSC(=O)N2)c1 to have a higher LogP value.,CS[C@H](C)c1cccc(NC(=O)[C@H]2CSC(=O)N2)c1,2.8741000000000003
114694,Optimize the molecule COc1ccccc1N1CCN(C(=O)N[C@@H]2CCc3c(O)cccc32)CC1 to have a lower LogP value.,COc1ccccc1N1CCN(C(=O)N[C@@H]2CCc3c(O)cccc32)CC1,2.919900000000001
104131,Please optimize the molecule CCn1nc(C)c2nc([C@@H](C)Cl)n(CC3CCOCC3)c21 to have a higher LogP value.,CCn1nc(C)c2nc([C@@H](C)Cl)n(CC3CCOCC3)c21,3.2875200000000016
133689,Modify the molecule CCOc1ccc2cc(C(=O)Nc3cccc(Cl)c3Cl)c(=O)oc2c1 to decrease its LogP value.,CCOc1ccc2cc(C(=O)Nc3cccc(Cl)c3Cl)c(=O)oc2c1,4.750800000000002
81276,Modify the molecule CC1CC(NS(=O)(=O)c2ccc(F)cc2Cl)C1 to have a higher LogP value.,CC1CC(NS(=O)(=O)c2ccc(F)cc2Cl)C1,2.555900000000001
230940,Optimize the molecule CCCCn1c(=O)[nH]c(=O)c2c1nc(-c1csc([N+](=O)[O-])c1)n2CC(C)C to have a lower LogP value.,CCCCn1c(=O)[nH]c(=O)c2c1nc(-c1csc([N+](=O)[O-])c1)n2CC(C)C,2.9791000000000016
113725,Please optimize the molecule CCc1nnc(CN2CC[NH+](C3CCC(C(C)C)CC3)CC2)o1 to have a higher LogP value.,CCc1nnc(CN2CC[NH+](C3CCC(C(C)C)CC3)CC2)o1,1.5473
174258,Modify the molecule CC(=O)c1ccc(N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O)cc1 to have a lower LogP value.,CC(=O)c1ccc(N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O)cc1,4.4821000000000035
210072,Modify the molecule C[C@@H](Nc1nc2ccc(F)cn2n1)C(=O)N(C)C to increase its LogP value.,C[C@@H](Nc1nc2ccc(F)cn2n1)C(=O)N(C)C,0.7569999999999997
191931,Optimize the molecule CC(=O)N1CCN(c2nccnc2[C@@H]2CCC[NH+]2C)CC1 to have a lower LogP value.,CC(=O)N1CCN(c2nccnc2[C@@H]2CCC[NH+]2C)CC1,-0.5052999999999981
17852,Modify the molecule O=C(CNC(=O)Nc1cccc(OCC(F)(F)F)c1)NC1CC1 to have a higher LogP value.,O=C(CNC(=O)Nc1cccc(OCC(F)(F)F)c1)NC1CC1,2.0278
206994,Modify the molecule O=C([C@@H]1CCCN(C2CC[NH+](Cc3ccccc3)CC2)C1)N1CCCCCCC1 to decrease its LogP value.,O=C([C@@H]1CCCN(C2CC[NH+](Cc3ccccc3)CC2)C1)N1CCCCCCC1,2.7386000000000017
36172,Modify the molecule CN(CCNC(=O)Nc1ccccc1CC(N)=O)c1ccccc1 to have a lower LogP value.,CN(CCNC(=O)Nc1ccccc1CC(N)=O)c1ccccc1,1.9722999999999997
175747,Please modify the molecule CC(C)[NH2+]Cc1ccn(Cc2nccs2)n1 to increase its LogP value.,CC(C)[NH2+]Cc1ccn(Cc2nccs2)n1,0.8596999999999991
176943,Modify the molecule O=S1(=O)CC[C@H](NC(=S)N[C@H]2CCS(=O)(=O)C2)C1 to increase its LogP value.,O=S1(=O)CC[C@H](NC(=S)N[C@H]2CCS(=O)(=O)C2)C1,-1.175299999999999
105891,Please optimize the molecule O=C(N[C@H]1C[C@H]2C(=O)N3CCC[C@@H]3C(=O)N2C1)c1ccc(F)c(C(F)(F)F)c1 to have a higher LogP value.,O=C(N[C@H]1C[C@H]2C(=O)N3CCC[C@@H]3C(=O)N2C1)c1ccc(F)c(C(F)(F)F)c1,1.5484000000000004
172048,Optimize the molecule CC[NH+]1CCN(c2ccc(C(=O)N[C@H](C)C(C)C)cc2)CC1 to have a lower LogP value.,CC[NH+]1CCN(c2ccc(C(=O)N[C@H](C)C(C)C)cc2)CC1,1.1857000000000018
44755,Please modify the molecule Cn1ccnc1[C@H](O)[C@H]1CCC[NH+](Cc2cccc(-c3cccnc3)c2)C1 to increase its LogP value.,Cn1ccnc1[C@H](O)[C@H]1CCC[NH+](Cc2cccc(-c3cccnc3)c2)C1,2.0105999999999997
13454,Modify the molecule CC[C@H](C)C(=O)N1CCc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C1 to decrease its LogP value.,CC[C@H](C)C(=O)N1CCc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C1,4.888500000000004
108536,Modify the molecule COc1cc(Cl)ccc1C(=O)NNC(=O)CC(C)(C)C to increase its LogP value.,COc1cc(Cl)ccc1C(=O)NNC(=O)CC(C)(C)C,2.5458000000000007
92424,Please modify the molecule CCN1CCO[C@@H](C(=O)N[C@@H](C#N)c2cccc(Cl)c2)C1 to increase its LogP value.,CCN1CCO[C@@H](C(=O)N[C@@H](C#N)c2cccc(Cl)c2)C1,1.74158
143601,Please optimize the molecule O=C(c1cc2ccccc2[nH]1)N1CCN(Cc2nc3ccccc3[nH]2)CC1 to have a higher LogP value.,O=C(c1cc2ccccc2[nH]1)N1CCN(Cc2nc3ccccc3[nH]2)CC1,3.002200000000001
233729,Please optimize the molecule C[NH+]1CCN2c3ccc([N+](=O)[O-])cc3C[C@]3(C(=O)N(c4ccc(F)cc4)C(=O)N=C3[O-])[C@@H]2C1 to have a lower LogP value.,C[NH+]1CCN2c3ccc([N+](=O)[O-])cc3C[C@]3(C(=O)N(c4ccc(F)cc4)C(=O)N=C3[O-])[C@@H]2C1,-0.09469999999999867
33476,Please optimize the molecule COC[C@@](C)(O)CNC(=O)C1(c2ccc(F)cc2)CC1 to have a higher LogP value.,COC[C@@](C)(O)CNC(=O)C1(c2ccc(F)cc2)CC1,1.3708999999999996
18190,Modify the molecule O=S(=O)(c1cccnc1)N1CCC(O)(C(F)(F)F)CC1 to have a lower LogP value.,O=S(=O)(c1cccnc1)N1CCC(O)(C(F)(F)F)CC1,1.1595000000000002
99417,Optimize the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CCC[C@H](O)C1 to have a lower LogP value.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CCC[C@H](O)C1,2.03362
217190,Please modify the molecule CCCCN1CNc2c(c(=O)[nH]c(=O)n2CCc2ccccc2)C1 to decrease its LogP value.,CCCCN1CNc2c(c(=O)[nH]c(=O)n2CCc2ccccc2)C1,1.7643999999999993
34295,Please optimize the molecule Cc1ncc(CSCCCC(C)(C)C#N)s1 to have a higher LogP value.,Cc1ncc(CSCCCC(C)(C)C#N)s1,4.014700000000003
67528,Optimize the molecule C[C@@H](C(=O)Nc1nccs1)N1CCN(C2=[NH+]CC(C)(C)S2)CC1 to have a higher LogP value.,C[C@@H](C(=O)Nc1nccs1)N1CCN(C2=[NH+]CC(C)(C)S2)CC1,0.04970000000000163
69514,Please modify the molecule CCS(=O)(=O)C[C@H](C)N(C)C(=O)Nc1cnn(Cc2ccccc2)c1 to decrease its LogP value.,CCS(=O)(=O)C[C@H](C)N(C)C(=O)Nc1cnn(Cc2ccccc2)c1,2.2182999999999993
76953,Please modify the molecule Nc1cc(-c2c[nH]nc2[C@H]2CCCN(S(=O)(=O)c3ccccc3)C2)ccn1 to decrease its LogP value.,Nc1cc(-c2c[nH]nc2[C@H]2CCCN(S(=O)(=O)c3ccccc3)C2)ccn1,2.622200000000001
98543,Optimize the molecule COc1ccccc1[C@@H](C)NC(=O)Cc1csc(-c2ccccc2)n1 to have a lower LogP value.,COc1ccccc1[C@@H](C)NC(=O)Cc1csc(-c2ccccc2)n1,4.238600000000003
218223,Optimize the molecule COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O to have a lower LogP value.,COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O,0.8328999999999995
202165,Modify the molecule C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1 to decrease its LogP value.,C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1,2.5229000000000017
10525,Modify the molecule COc1ccc([C@@H](O)[C@@H](C)NC(=O)CN2CCCCCC2=O)cc1 to have a lower LogP value.,COc1ccc([C@@H](O)[C@@H](C)NC(=O)CN2CCCCCC2=O)cc1,1.6358999999999992
184600,Modify the molecule CCCc1cc(C(=O)NC[C@@H]2CC[C@H](C(=O)[O-])O2)sc1C to decrease its LogP value.,CCCc1cc(C(=O)NC[C@@H]2CC[C@H](C(=O)[O-])O2)sc1C,1.0363199999999997
63019,Please modify the molecule Cc1cccc2cc([C@@H](c3nnnn3C[C@H]3CCCO3)[NH+]3CCCCC3)c(=O)[nH]c12 to increase its LogP value.,Cc1cccc2cc([C@@H](c3nnnn3C[C@H]3CCCO3)[NH+]3CCCCC3)c(=O)[nH]c12,1.16022
133040,Please modify the molecule CCNC(=O)C[NH2+]Cc1csc(C(C)(C)C)n1 to increase its LogP value.,CCNC(=O)C[NH2+]Cc1csc(C(C)(C)C)n1,0.6401000000000001
241714,Please modify the molecule Cc1cc(C)c(NC(=S)N(Cc2cccnc2)Cc2cccnc2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(NC(=S)N(Cc2cccnc2)Cc2cccnc2)c(C)c1,4.801060000000004
212832,Please optimize the molecule CCN(CC)c1ncnc2c1cnn2CC(=O)Nc1cc(C)ccc1OC to have a lower LogP value.,CCN(CC)c1ncnc2c1cnn2CC(=O)Nc1cc(C)ccc1OC,2.6282200000000007
154970,Please optimize the molecule Nc1cccc(Cl)c1SCCOc1ccccc1 to have a higher LogP value.,Nc1cccc(Cl)c1SCCOc1ccccc1,4.093300000000002
148696,Modify the molecule Cc1cccc(Oc2ccc(Cl)cc2NC(=O)Cn2cc[nH+]c2)c1 to have a higher LogP value.,Cc1cccc(Oc2ccc(Cl)cc2NC(=O)Cn2cc[nH+]c2)c1,3.6950200000000013
155842,Optimize the molecule C[C@@H]1CN(c2c(F)c(F)nc(F)c2F)CCCO1 to have a lower LogP value.,C[C@@H]1CN(c2c(F)c(F)nc(F)c2F)CCCO1,2.2532000000000005
231346,Modify the molecule C[C@H](C(=O)Nc1ccc2oc(=O)[nH]c2c1)c1ccsc1 to have a higher LogP value.,C[C@H](C(=O)Nc1ccc2oc(=O)[nH]c2c1)c1ccsc1,2.9248000000000003
126863,Modify the molecule C[C@@H]1[C@H](C(=O)[O-])CCN1C(=O)C1CCC(C(C)(C)C)CC1 to increase its LogP value.,C[C@@H]1[C@H](C(=O)[O-])CCN1C(=O)C1CCC(C(C)(C)C)CC1,1.8257999999999996
10453,Optimize the molecule Cc1cc(C)c(NNC(=O)[C@H](C)OCC(F)(F)F)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(NNC(=O)[C@H](C)OCC(F)(F)F)c(C)c1,3.0223600000000017
198115,Optimize the molecule C[C@@H](C(=O)N(C)Cc1ccc(O)cc1)S(C)(=O)=O to have a lower LogP value.,C[C@@H](C(=O)N(C)Cc1ccc(O)cc1)S(C)(=O)=O,0.7837000000000001
116387,Optimize the molecule COc1ccc2c(c1)[C@H]([NH2+]CCNc1ncccc1C(F)(F)F)CCO2 to have a lower LogP value.,COc1ccc2c(c1)[C@H]([NH2+]CCNc1ncccc1C(F)(F)F)CCO2,2.6081000000000003
51625,Modify the molecule O=C(c1ccc(Cl)cc1F)N1CCN(Cc2cc[nH]n2)CC1 to have a higher LogP value.,O=C(c1ccc(Cl)cc1F)N1CCN(Cc2cc[nH]n2)CC1,2.1601999999999997
118738,Optimize the molecule CC[C@H]1CCCN(C(=O)CC2([NH3+])CCC2)C1 to have a lower LogP value.,CC[C@H]1CCCN(C(=O)CC2([NH3+])CCC2)C1,1.1897000000000002
147248,Optimize the molecule O=C([O-])[C@@H]1CCCN(C(=O)c2cc(Br)c[nH]2)C1 to have a higher LogP value.,O=C([O-])[C@@H]1CCCN(C(=O)c2cc(Br)c[nH]2)C1,0.3793
181759,Please optimize the molecule Cc1cc(C)c2nc(SCC(=O)c3ccc4c(c3)OCCO4)c(C#N)cc2c1 to have a lower LogP value.,Cc1cc(C)c2nc(SCC(=O)c3ccc4c(c3)OCCO4)c(C#N)cc2c1,4.469520000000004
161179,Modify the molecule C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)NCCc3ccncc3)c2)C1 to increase its LogP value.,C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)NCCc3ccncc3)c2)C1,2.4747000000000003
50822,Please optimize the molecule Cc1cc(C)n2nc(CC(=O)O[C@H](C)c3nc4ccccc4n3C)nc2n1 to have a higher LogP value.,Cc1cc(C)n2nc(CC(=O)O[C@H](C)c3nc4ccccc4n3C)nc2n1,2.4747400000000006
42722,Please modify the molecule CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21 to decrease its LogP value.,CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21,4.443400000000003
127969,Optimize the molecule CC(C)[C@H](CO)NC(=O)NC12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,CC(C)[C@H](CO)NC(=O)NC12CC3CC(CC(C3)C1)C2,2.2713
73271,Modify the molecule CNC(=O)CSCc1nc(C)cs1 to have a higher LogP value.,CNC(=O)CSCc1nc(C)cs1,1.43072
54720,Modify the molecule O=C([C@H]1Cc2ccccc2O1)N1CCCC[C@@H]1c1nccs1 to have a lower LogP value.,O=C([C@H]1Cc2ccccc2O1)N1CCCC[C@@H]1c1nccs1,3.200400000000002
157136,Optimize the molecule Cc1cc(C(=O)N2CCCC2)ccc1NC(=O)NC[C@H](C)c1ccsc1 to have a higher LogP value.,Cc1cc(C(=O)N2CCCC2)ccc1NC(=O)NC[C@H](C)c1ccsc1,4.217720000000003
173035,Please modify the molecule Cc1ccc([C@@H](O)[C@]2(C[NH3+])CCOC2)o1 to decrease its LogP value.,Cc1ccc([C@@H](O)[C@]2(C[NH3+])CCOC2)o1,0.27001999999999954
24322,Please modify the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])[C@H]2SCCc3ccccc32)c(F)c1 to increase its LogP value.,Cc1ccc(S(=O)(=O)/N=C(\[O-])[C@H]2SCCc3ccccc32)c(F)c1,2.6122200000000007
181838,Please modify the molecule Cc1ccc(C(=O)Oc2ccc(N3C(=O)CCC3=O)c(C)c2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)Oc2ccc(N3C(=O)CCC3=O)c(C)c2)cc1,3.176040000000002
6024,Modify the molecule CO[C@H]1CCC[C@@H](OC(=O)c2ccc(Cl)c(N3CCNC3=O)c2)C1 to have a lower LogP value.,CO[C@H]1CCC[C@@H](OC(=O)c2ccc(Cl)c(N3CCNC3=O)c2)C1,2.984000000000001
131350,Optimize the molecule CN(c1ccccc1)c1ccccc1C(=O)Nc1nccn(C)c1=O to have a higher LogP value.,CN(c1ccccc1)c1ccccc1C(=O)Nc1nccn(C)c1=O,2.8005000000000004
180314,Please modify the molecule O=C(c1cc(Br)c[nH]1)N1CCc2ccc(Cl)cc2C1 to decrease its LogP value.,O=C(c1cc(Br)c[nH]1)N1CCc2ccc(Cl)cc2C1,3.629100000000002
141871,Please optimize the molecule CN(CCCc1ccccc1)C(=O)c1[nH]ncc1Br to have a higher LogP value.,CN(CCCc1ccccc1)C(=O)c1[nH]ncc1Br,2.8770000000000007
64867,Modify the molecule C[C@@H](NC(=O)CSc1nc2ccccc2n1C)c1ccco1 to have a higher LogP value.,C[C@@H](NC(=O)CSc1nc2ccccc2n1C)c1ccco1,3.1358000000000015
196812,Optimize the molecule COc1ccc(OCC(=O)N(C)Cc2ccc(N(C)C)cc2)cc1 to have a higher LogP value.,COc1ccc(OCC(=O)N(C)Cc2ccc(N(C)C)cc2)cc1,2.7986000000000013
1050,Optimize the molecule Cc1cccc(NC(=O)[C@@H](C)[NH+]2CCC[C@H](c3nncn3C3CC3)C2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)[C@@H](C)[NH+]2CCC[C@H](c3nncn3C3CC3)C2)c1,1.710919999999999
8555,Modify the molecule C#CCN(CC#C)CC(=O)NCc1ccc(OC)cc1 to have a lower LogP value.,C#CCN(CC#C)CC(=O)NCc1ccc(OC)cc1,0.8797999999999995
43280,Modify the molecule O=C(NCCNc1cccc[nH+]1)c1ccc(Br)c(O)c1 to increase its LogP value.,O=C(NCCNc1cccc[nH+]1)c1ccc(Br)c(O)c1,1.8106999999999993
111413,Please modify the molecule CC(=O)NCCc1ccc(C(=O)c2cc3cc(Cl)ccc3o2)cc1 to increase its LogP value.,CC(=O)NCCc1ccc(C(=O)c2cc3cc(Cl)ccc3o2)cc1,3.9958000000000027
155773,Please modify the molecule Cc1ccc(S(=O)(=O)N/N=C/c2cn(-c3ccccc3)nc2-c2ccccc2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N/N=C/c2cn(-c3ccccc3)nc2-c2ccccc2)cc1,4.160120000000003
158003,Modify the molecule Cc1cc([C@@H]2CCCN2C(=O)Cc2cn(C)c3ccccc23)no1 to increase its LogP value.,Cc1cc([C@@H]2CCCN2C(=O)Cc2cn(C)c3ccccc23)no1,3.3809200000000024
78522,Optimize the molecule Cc1ocnc1C(=O)N1CC[C@]2(CCC[NH+](CCC3CCCCC3)C2)C1 to have a lower LogP value.,Cc1ocnc1C(=O)N1CC[C@]2(CCC[NH+](CCC3CCCCC3)C2)C1,2.4644199999999996
150410,Please modify the molecule O=S(=O)(N/N=C1\CCCC[C@H]1c1ccccc1)c1ccccc1 to decrease its LogP value.,O=S(=O)(N/N=C1\CCCC[C@H]1c1ccccc1)c1ccccc1,3.6787000000000027
234815,Modify the molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccc(F)cc1OCC(F)F to have a higher LogP value.,O=C(CCc1c[nH]c2ccccc12)Nc1ccc(F)cc1OCC(F)F,4.522200000000002
87885,Optimize the molecule CCc1ccc(CN[C@H](CC)C(=O)Nc2cc(C)on2)s1 to have a lower LogP value.,CCc1ccc(CN[C@H](CC)C(=O)Nc2cc(C)on2)s1,3.1138200000000014
197047,Modify the molecule CCCn1cc(N)c(=O)n(C[C@@H]2CN(C)CCO2)c1=O to have a lower LogP value.,CCCn1cc(N)c(=O)n(C[C@@H]2CN(C)CCO2)c1=O,-0.6671999999999991
113393,Please optimize the molecule N#Cc1ccc(N2CCC(C(=O)NCc3ccccc3F)CC2)nc1 to have a lower LogP value.,N#Cc1ccc(N2CCC(C(=O)NCc3ccccc3F)CC2)nc1,2.625180000000001
77776,Optimize the molecule CC[C@@](C)(NC(=O)CN1CCCOC1=O)c1nc(C)cs1 to have a higher LogP value.,CC[C@@](C)(NC(=O)CN1CCCOC1=O)c1nc(C)cs1,2.0352200000000003
200559,Please optimize the molecule O=C(NCc1cccnc1OCc1ccccc1)N1CCC[C@@H](O)C1 to have a higher LogP value.,O=C(NCc1cccnc1OCc1ccccc1)N1CCC[C@@H](O)C1,2.3269
84499,Please modify the molecule C[NH2+][C@@]1(C(=O)[O-])CCC[C@H](N(C)C2CC[NH+](C)CC2)C1 to increase its LogP value.,C[NH2+][C@@]1(C(=O)[O-])CCC[C@H](N(C)C2CC[NH+](C)CC2)C1,-2.7801999999999945
114204,Modify the molecule CC(CO)(CO)NC(=O)Nc1cc(Cl)ccc1OCC(F)(F)F to decrease its LogP value.,CC(CO)(CO)NC(=O)Nc1cc(Cl)ccc1OCC(F)(F)F,2.1459
240602,Please modify the molecule CC(C)C(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1 to increase its LogP value.,CC(C)C(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1,3.376800000000002
217183,Modify the molecule COc1nc2c(cc1C(=O)NCc1cnc(SC)n1C)CCC2 to decrease its LogP value.,COc1nc2c(cc1C(=O)NCc1cnc(SC)n1C)CCC2,1.9643
205602,Modify the molecule C[C@@H](CCO)C[NH2+]C[C@H]1CN(C)CCO1 to have a lower LogP value.,C[C@@H](CCO)C[NH2+]C[C@H]1CN(C)CCO1,-1.101099999999998
23057,Modify the molecule CC(=O)NCCc1cc(C)no1 to decrease its LogP value.,CC(=O)NCCc1cc(C)no1,0.6616200000000001
249061,Optimize the molecule NC(=O)C[NH+](CC(=O)N1CCC[C@@H](C(F)(F)F)C1)C1CCCC1 to have a lower LogP value.,NC(=O)C[NH+](CC(=O)N1CCC[C@@H](C(F)(F)F)C1)C1CCCC1,0.10010000000000163
127231,Modify the molecule O=C([O-])CC1(CSC[C@H]2C[C@H]3CC[C@@H]2C3)CC1 to have a lower LogP value.,O=C([O-])CC1(CSC[C@H]2C[C@H]3CC[C@@H]2C3)CC1,2.0759999999999996
166139,Optimize the molecule CCCCN1C(=O)[C@@H]2[C@H]3CCCN3[C@]3(C(=O)Nc4ccc(Br)cc43)[C@@H]2C1=O to have a higher LogP value.,CCCCN1C(=O)[C@@H]2[C@H]3CCCN3[C@]3(C(=O)Nc4ccc(Br)cc43)[C@@H]2C1=O,2.4758000000000004
144968,Please modify the molecule C[NH2+][C@@H](CC[C@@H]1CCCCO1)[C@H](C)c1ccccn1 to increase its LogP value.,C[NH2+][C@@H](CC[C@@H]1CCCCO1)[C@H](C)c1ccccn1,2.0961999999999996
143572,Optimize the molecule Cc1ccc2sc(N(CC[NH+](C)C)C(=O)Cc3ccccc3)nc2c1C to have a lower LogP value.,Cc1ccc2sc(N(CC[NH+](C)C)C(=O)Cc3ccccc3)nc2c1C,2.6333400000000005
234780,Modify the molecule Cc1ccccc1NS(=O)(=O)c1cc2c3c(c1)CC(=O)N3CCC2 to increase its LogP value.,Cc1ccccc1NS(=O)(=O)c1cc2c3c(c1)CC(=O)N3CCC2,2.631120000000001
185028,Modify the molecule Cn1cccc(C(=O)N2CCC(CNC(=O)c3cnc4ccccc4n3)CC2)c1=O to decrease its LogP value.,Cn1cccc(C(=O)N2CCC(CNC(=O)c3cnc4ccccc4n3)CC2)c1=O,1.6106999999999998
19027,Please modify the molecule CC[NH2+][C@@H](c1ccsc1)[C@@H]1CCOC2(CCCC2)C1 to decrease its LogP value.,CC[NH2+][C@@H](c1ccsc1)[C@@H]1CCOC2(CCCC2)C1,3.111900000000002
34696,Optimize the molecule CCN(C(=O)Nc1cccnc1-n1cccn1)[C@H](C)c1cccc(OC)c1 to have a higher LogP value.,CCN(C(=O)Nc1cccnc1-n1cccn1)[C@H](C)c1cccc(OC)c1,3.890900000000003
60916,Please optimize the molecule Cc1nc(C)c(C(=O)N2CSC[C@@H]2C(=O)NC(C)(C)C)o1 to have a higher LogP value.,Cc1nc(C)c(C(=O)N2CSC[C@@H]2C(=O)NC(C)(C)C)o1,1.7212399999999997
12380,Please optimize the molecule COc1cc([C@H]2c3cc4c(cc3O[C@@](C)([NH+]3CCCC3)[C@@H]2C)OCO4)cc(OC)c1OC to have a lower LogP value.,COc1cc([C@H]2c3cc4c(cc3O[C@@](C)([NH+]3CCCC3)[C@@H]2C)OCO4)cc(OC)c1OC,2.9964000000000013
138815,Modify the molecule Cc1csc(N2CCN(CCn3cncn3)CC2)n1 to increase its LogP value.,Cc1csc(N2CCN(CCn3cncn3)CC2)n1,0.8652199999999999
174125,Please optimize the molecule CCCc1nnc2n1N[C@H](c1ccccc1)[C@H](C(=O)Nc1cc(C)cc(C)c1)S2 to have a lower LogP value.,CCCc1nnc2n1N[C@H](c1ccccc1)[C@H](C(=O)Nc1cc(C)cc(C)c1)S2,4.245240000000003
4699,Modify the molecule CC[NH2+][C@H]([C@@H]1CN2CCC[C@@H]2CO1)[C@@H]1CCCC[C@H]1CC to increase its LogP value.,CC[NH2+][C@H]([C@@H]1CN2CCC[C@@H]2CO1)[C@@H]1CCCC[C@H]1CC,2.0178999999999996
66232,Please modify the molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1C[NH+]1C[C@@H]2CCC[C@H](C1)C2O to increase its LogP value.,Cc1nn(-c2ccc(F)cc2F)c(C)c1C[NH+]1C[C@@H]2CCC[C@H](C1)C2O,1.9430400000000003
176522,Please optimize the molecule CN1CC2(CCN(Cc3[nH+]ccn3C)CC2)OC1=O to have a higher LogP value.,CN1CC2(CCN(Cc3[nH+]ccn3C)CC2)OC1=O,0.25580000000000047
58310,Please modify the molecule O=C(Nc1ccc(-c2ccccc2)cc1)C(=O)N1CC[C@H]([NH+]2CCCC2)C1 to decrease its LogP value.,O=C(Nc1ccc(-c2ccccc2)cc1)C(=O)N1CC[C@H]([NH+]2CCCC2)C1,1.5716999999999994
193037,Modify the molecule CN(C(=O)CSc1nnc(-c2ccncc2)o1)C1CCCCC1 to increase its LogP value.,CN(C(=O)CSc1nnc(-c2ccncc2)o1)C1CCCCC1,3.014800000000001
147325,Modify the molecule COc1ccc2nc(N(Cc3cccnc3)C(=O)c3ccc(C(F)(F)F)cc3)sc2c1 to decrease its LogP value.,COc1ccc2nc(N(Cc3cccnc3)C(=O)c3ccc(C(F)(F)F)cc3)sc2c1,5.565700000000003
239800,Please optimize the molecule C[C@@H](NS(=O)(=O)Cc1ccon1)c1cccc(Cl)c1 to have a higher LogP value.,C[C@@H](NS(=O)(=O)Cc1ccon1)c1cccc(Cl)c1,2.5086000000000004
197622,Please modify the molecule N#CCOc1cccc(CC(=O)N2CCC2)c1 to decrease its LogP value.,N#CCOc1cccc(CC(=O)N2CCC2)c1,1.36378
19751,Please optimize the molecule COc1ccc(SCCC(=O)Nc2nnc(-c3cc(Cl)sc3Cl)o2)cc1 to have a lower LogP value.,COc1ccc(SCCC(=O)Nc2nnc(-c3cc(Cl)sc3Cl)o2)cc1,5.234400000000003
189032,Please optimize the molecule COCCCN1C(=O)c2cccc(N3CC[NH+](Cc4ccc5c(c4)Cc4ccccc4-5)CC3)c2C1=O to have a higher LogP value.,COCCCN1C(=O)c2cccc(N3CC[NH+](Cc4ccc5c(c4)Cc4ccccc4-5)CC3)c2C1=O,2.7954000000000017
55951,Modify the molecule COc1ccc(N2CCN(C(=O)[C@@H](NC(=O)c3cccc(C)c3)C(C)C)CC2)cc1 to decrease its LogP value.,COc1ccc(N2CCN(C(=O)[C@@H](NC(=O)c3cccc(C)c3)C(C)C)CC2)cc1,3.106820000000001
58420,Please optimize the molecule Cc1cccc(-c2nn3c(=O)cc(N4CCN(S(=O)(=O)c5ccc(F)cc5)CC4)nc3s2)c1 to have a higher LogP value.,Cc1cccc(-c2nn3c(=O)cc(N4CCN(S(=O)(=O)c5ccc(F)cc5)CC4)nc3s2)c1,2.7764200000000008
11707,Optimize the molecule CC(C)c1n[nH]c(/N=C(\[O-])[C@H]2SCCc3ccccc32)n1 to have a lower LogP value.,CC(C)c1n[nH]c(/N=C(\[O-])[C@H]2SCCc3ccccc32)n1,2.349
235381,Optimize the molecule CCOC(=O)[C@@H](C)n1cnc2sc(C(=O)Nc3ccc(C)cc3C)c(C)c2c1=O to have a lower LogP value.,CCOC(=O)[C@@H](C)n1cnc2sc(C(=O)Nc3ccc(C)cc3C)c(C)c2c1=O,3.759660000000002
226233,Please optimize the molecule CCn1cnnc1-c1cccc(NC(=O)[C@H]2CCCN(C(=O)c3ccc(Cl)cc3)C2)c1 to have a lower LogP value.,CCn1cnnc1-c1cccc(NC(=O)[C@H]2CCCN(C(=O)c3ccc(Cl)cc3)C2)c1,4.109300000000003
246809,Modify the molecule CC(C)C(=O)N[C@@H]1CCC[C@@H]1c1ccccc1C(F)(F)F to have a lower LogP value.,CC(C)C(=O)N[C@@H]1CCC[C@@H]1c1ccccc1C(F)(F)F,4.113700000000003
67970,Optimize the molecule CC(=O)N1CCC([NH2+]CCOc2ccc(Cl)cc2)CC1 to have a higher LogP value.,CC(=O)N1CCC([NH2+]CCOc2ccc(Cl)cc2)CC1,1.2931000000000004
12968,Optimize the molecule Cc1cc(C)nc([C@H](C#N)C(=O)c2ccc([N+](=O)[O-])cc2)n1 to have a lower LogP value.,Cc1cc(C)nc([C@H](C#N)C(=O)c2ccc([N+](=O)[O-])cc2)n1,2.49172
16639,Optimize the molecule CC(C)C(=O)N(C)c1nc(-c2ccc3c(c2)CCCN3C(=O)C2CCCC2)cs1 to have a higher LogP value.,CC(C)C(=O)N(C)c1nc(-c2ccc3c(c2)CCCN3C(=O)C2CCCC2)cs1,4.898300000000005
56551,Optimize the molecule Cc1nn(C)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,Cc1nn(C)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1,1.1848199999999998
39374,Modify the molecule N#Cc1c2ncn(CC(=O)c3ccc(Br)cc3)c(=O)c2c2n1CCC2 to have a higher LogP value.,N#Cc1c2ncn(CC(=O)c3ccc(Br)cc3)c(=O)c2c2n1CCC2,2.6612800000000005
107858,Please optimize the molecule CN(C)CC[NH+]1CCC(NC(=O)NC[C@@H]2CN3CCCC[C@@H]3CO2)CC1 to have a lower LogP value.,CN(C)CC[NH+]1CCC(NC(=O)NC[C@@H]2CN3CCCC[C@@H]3CO2)CC1,-0.8521999999999941
144427,Modify the molecule O=C1C[C@@H](C(=O)N2CCN(c3nccs3)CC2)CN1Cc1ccccn1 to decrease its LogP value.,O=C1C[C@@H](C(=O)N2CCN(c3nccs3)CC2)CN1Cc1ccccn1,1.2353999999999992
33708,Please optimize the molecule O=C(Nc1cc2c(cc1Cl)OCO2)[C@H]1COc2ccc(F)cc2C1 to have a lower LogP value.,O=C(Nc1cc2c(cc1Cl)OCO2)[C@H]1COc2ccc(F)cc2C1,3.3976000000000024
1220,Modify the molecule C=CCN1C(=O)/C(=C/c2cccc(C)c2)S/C1=N/c1nnc(C)s1 to have a lower LogP value.,C=CCN1C(=O)/C(=C/c2cccc(C)c2)S/C1=N/c1nnc(C)s1,3.9449400000000034
118033,Please modify the molecule [O-]/C(=C\SCc1ccccc1)N1CCc2ccccc21 to decrease its LogP value.,[O-]/C(=C\SCc1ccccc1)N1CCc2ccccc21,3.141700000000002
136189,Optimize the molecule O=Cc1cc(OCc2ccccc2)ccc1Br to have a lower LogP value.,O=Cc1cc(OCc2ccccc2)ccc1Br,3.840600000000002
98152,Please modify the molecule Cc1ccccc1-c1noc(=O)n1CC(=O)Nc1c(C)nn(C)c1C to increase its LogP value.,Cc1ccccc1-c1noc(=O)n1CC(=O)Nc1c(C)nn(C)c1C,1.8007599999999997
147528,Modify the molecule O=C([O-])Cc1ccc(NC(=O)c2ccc(N3C(=O)c4ccccc4C3=O)cc2)cc1 to have a higher LogP value.,O=C([O-])Cc1ccc(NC(=O)c2ccc(N3C(=O)c4ccccc4C3=O)cc2)cc1,2.0318999999999994
189417,Please modify the molecule CCC[NH+](CC)[C@H](C)C(=O)Nc1c(Cl)cc(N)cc1Cl to increase its LogP value.,CCC[NH+](CC)[C@H](C)C(=O)Nc1c(Cl)cc(N)cc1Cl,2.2173999999999996
36992,Modify the molecule CNC(=O)[C@H](C)Sc1nncn1C to increase its LogP value.,CNC(=O)[C@H](C)Sc1nncn1C,0.041699999999999404
214658,Modify the molecule CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1 to decrease its LogP value.,CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1,3.4049000000000023
177111,Modify the molecule Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1 to have a lower LogP value.,Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1,1.39722
222227,Please modify the molecule c1ccc(-c2nnn3c2nc(NCc2cccnc2)c2ccccc23)cc1 to decrease its LogP value.,c1ccc(-c2nnn3c2nc(NCc2cccnc2)c2ccccc23)cc1,3.9516000000000027
140030,Modify the molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)N2CCCCC[C@@H]2c2cccn2C)cc1 to have a lower LogP value.,COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)N2CCCCC[C@@H]2c2cccn2C)cc1,4.616300000000004
111109,Modify the molecule CC(=O)c1ccc(S(=O)(=O)N2CCO[C@@H](c3ccc(Cl)cc3)C2)cc1 to decrease its LogP value.,CC(=O)c1ccc(S(=O)(=O)N2CCO[C@@H](c3ccc(Cl)cc3)C2)cc1,3.304800000000002
230812,Please optimize the molecule O=C(Nc1cc(Cl)ccc1OCC(F)(F)F)c1ccnnc1 to have a lower LogP value.,O=C(Nc1cc(Cl)ccc1OCC(F)(F)F)c1ccnnc1,3.3234000000000012
113610,Please modify the molecule C=C(C)[C@H](O)C1CCC(C)CC1 to decrease its LogP value.,C=C(C)[C@H](O)C1CCC(C)CC1,2.7497000000000007
246221,Modify the molecule CC(C)[C@H]1CC[C@H](C)C[C@@]1([NH3+])Cc1nccs1 to increase its LogP value.,CC(C)[C@H]1CC[C@H](C)C[C@@]1([NH3+])Cc1nccs1,2.7585000000000006
7898,Modify the molecule Cc1ocnc1CNC(=O)N[C@@H]1CCCC[C@H]1CNC(=O)OC(C)(C)C to have a higher LogP value.,Cc1ocnc1CNC(=O)N[C@@H]1CCCC[C@H]1CNC(=O)OC(C)(C)C,2.8657200000000005
223530,Optimize the molecule CSc1nsc(NC(=O)c2cnc(-c3cccs3)s2)n1 to have a higher LogP value.,CSc1nsc(NC(=O)c2cnc(-c3cccs3)s2)n1,3.6973000000000003
18762,Modify the molecule CC(C)n1cnnc1SCC(=O)N(C)Cc1cnn(C)c1 to decrease its LogP value.,CC(C)n1cnnc1SCC(=O)N(C)Cc1cnn(C)c1,1.3431999999999997
40040,Modify the molecule COc1ccc(C)cc1NC(=O)CSC1=NCCS1 to decrease its LogP value.,COc1ccc(C)cc1NC(=O)CSC1=NCCS1,2.7781200000000013
98097,Optimize the molecule Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1 to have a higher LogP value.,Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1,4.550760000000005
230463,Modify the molecule CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1 to have a higher LogP value.,CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1,0.12500000000000178
95775,Please modify the molecule CCC1=C(C)N(C(C)(C)C(=O)[O-])N(C(=O)C(C)C)c2ccccc21 to increase its LogP value.,CCC1=C(C)N(C(C)(C)C(=O)[O-])N(C(=O)C(C)C)c2ccccc21,2.5757000000000003
17034,Please optimize the molecule Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1 to have a lower LogP value.,Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1,4.119940000000003
118901,Please modify the molecule COc1ccc(CCNCc2cnc(SC)nc2)cc1 to increase its LogP value.,COc1ccc(CCNCc2cnc(SC)nc2)cc1,2.5394000000000005
178054,Modify the molecule CC[NH+](CC(=O)NC1(C#N)CCCCC1)C[C@H](O)c1ccc(C)cc1 to have a higher LogP value.,CC[NH+](CC(=O)NC1(C#N)CCCCC1)C[C@H](O)c1ccc(C)cc1,1.2759
162856,Please modify the molecule C[C@@H]1CN(Cc2cccc(Cl)n2)CC[NH2+]1 to decrease its LogP value.,C[C@@H]1CN(Cc2cccc(Cl)n2)CC[NH2+]1,0.5025000000000001
36649,Optimize the molecule CC[C@H](NC(=O)N[C@H]1CC[C@H](SC)C1)c1cccs1 to have a lower LogP value.,CC[C@H](NC(=O)N[C@H]1CC[C@H](SC)C1)c1cccs1,3.7825000000000024
193208,Modify the molecule CCN1C(=O)N[C@H](c2cccc(F)c2)C2=C1CN(CCC(=O)NCC(C)C)C2=O to have a lower LogP value.,CCN1C(=O)N[C@H](c2cccc(F)c2)C2=C1CN(CCC(=O)NCC(C)C)C2=O,2.1704999999999997
192365,Modify the molecule CN(Cc1ccncn1)c1ccc(-c2nc(Cc3ccc(F)cc3)no2)cn1 to increase its LogP value.,CN(Cc1ccncn1)c1ccc(-c2nc(Cc3ccc(F)cc3)no2)cn1,3.2879000000000014
224276,Please optimize the molecule Cc1nc(NC(=O)c2cc3c([nH]c2=O)CCCC3)sc1-c1ccccc1 to have a lower LogP value.,Cc1nc(NC(=O)c2cc3c([nH]c2=O)CCCC3)sc1-c1ccccc1,3.9379200000000028
240891,Modify the molecule CCOc1ccc(Br)cc1/C=C/C(=O)NCCC(=O)[O-] to have a higher LogP value.,CCOc1ccc(Br)cc1/C=C/C(=O)NCCC(=O)[O-],1.1171999999999993
210355,Please optimize the molecule Cc1csc([C@H]2CCC[NH+](Cc3cc(C)oc3C)C2)n1 to have a higher LogP value.,Cc1csc([C@H]2CCC[NH+](Cc3cc(C)oc3C)C2)n1,2.6238600000000005
109065,Please modify the molecule O=C(CCSc1ccc(F)cc1)NNC(=O)[C@@H]1C[C@@H]1[N+](=O)[O-] to decrease its LogP value.,O=C(CCSc1ccc(F)cc1)NNC(=O)[C@@H]1C[C@@H]1[N+](=O)[O-],1.1204999999999998
223009,Modify the molecule C[C@@H]([NH3+])c1ccc(N(C)CCC(F)(F)F)cc1O to have a higher LogP value.,C[C@@H]([NH3+])c1ccc(N(C)CCC(F)(F)F)cc1O,2.0837000000000008
6808,Modify the molecule COc1ccccc1C(C)(C)CNC(=O)c1c(C)nn(C)c1OC to increase its LogP value.,COc1ccccc1C(C)(C)CNC(=O)c1c(C)nn(C)c1OC,2.4533200000000006
12085,Optimize the molecule CC[C@@H](CNC(=O)c1ccccc1F)Oc1cccc(F)c1 to have a lower LogP value.,CC[C@@H](CNC(=O)c1ccccc1F)Oc1cccc(F)c1,3.5522000000000027
51709,Modify the molecule COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1 to decrease its LogP value.,COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1,2.758020000000001
60478,Please modify the molecule CCC(CC)N1C(=O)C2(CCCCC2)NC(=O)C1(C)C to increase its LogP value.,CCC(CC)N1C(=O)C2(CCCCC2)NC(=O)C1(C)C,2.6149000000000004
184887,Please optimize the molecule IC[C@@H]1CC[C@@H]2CCCC[C@@H]2C1 to have a higher LogP value.,IC[C@@H]1CC[C@@H]2CCCC[C@@H]2C1,4.027900000000003
219974,Modify the molecule O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(OC(F)(F)F)cc1 to decrease its LogP value.,O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(OC(F)(F)F)cc1,3.323900000000001
212185,Please modify the molecule C[C@@H](C(=O)Nc1ccc(Cl)cc1)n1ncc(-c2ccc(Cl)cc2)nc1=O to increase its LogP value.,C[C@@H](C(=O)Nc1ccc(Cl)cc1)n1ncc(-c2ccc(Cl)cc2)nc1=O,3.8118000000000025
924,Please modify the molecule O=C(COc1ccc(Br)cc1)NOCc1ccccc1 to increase its LogP value.,O=C(COc1ccc(Br)cc1)NOCc1ccccc1,3.0759000000000007
32157,Please modify the molecule C[C@@H](NC(=O)[C@@H](C)[NH+]1CCCC1)c1ccccc1 to increase its LogP value.,C[C@@H](NC(=O)[C@@H](C)[NH+]1CCCC1)c1ccccc1,0.9310000000000003
108690,Please modify the molecule NS(=O)(=O)N1CCc2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc21 to increase its LogP value.,NS(=O)(=O)N1CCc2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc21,1.9948
102861,Please modify the molecule CCCn1c(-c2ccc(SC)cc2)nc2c1c(=O)[nH]c(=O)n2Cc1ccccc1 to increase its LogP value.,CCCn1c(-c2ccc(SC)cc2)nc2c1c(=O)[nH]c(=O)n2Cc1ccccc1,3.733500000000002
61660,Please optimize the molecule Cc1ccc(C)c(CS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1 to have a lower LogP value.,Cc1ccc(C)c(CS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1,3.1855400000000014
141460,Modify the molecule CNS(=O)(=O)c1ccc(NC(=O)/C=C/c2ccc(SC)cc2)cc1 to increase its LogP value.,CNS(=O)(=O)c1ccc(NC(=O)/C=C/c2ccc(SC)cc2)cc1,2.9685000000000015
36861,Optimize the molecule COC(=O)C(C)(C)[C@H]1CCCN(CN2C(=O)C[C@@](C)(C(C)C)C2=O)C1 to have a higher LogP value.,COC(=O)C(C)(C)[C@H]1CCCN(CN2C(=O)C[C@@](C)(C(C)C)C2=O)C1,2.2763
193275,Please optimize the molecule O=C(CCN1CCn2c(nnc2C2CC2)C1)NC1CCCC1 to have a lower LogP value.,O=C(CCN1CCn2c(nnc2C2CC2)C1)NC1CCCC1,1.419999999999999
243223,Modify the molecule COc1ccc2c(cnn2CCC(=O)N2CCN(Cc3cccc(C)c3)CC2)c1 to increase its LogP value.,COc1ccc2c(cnn2CCC(=O)N2CCN(Cc3cccc(C)c3)CC2)c1,3.0878200000000016
245539,Please optimize the molecule C[C@H]1CCC[C@H](C)N1C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)c(Cl)c1 to have a higher LogP value.,C[C@H]1CCC[C@H](C)N1C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)c(Cl)c1,5.517700000000005
213284,Modify the molecule CC1(CNC(=O)c2ncccc2C(F)(F)F)CCC1 to have a lower LogP value.,CC1(CNC(=O)c2ncccc2C(F)(F)F)CCC1,3.020400000000002
60849,Please optimize the molecule CS(=O)(=O)c1ccc(Cc2nnc(NC(=O)C34CC5CC(CC(C5)C3)C4)o2)cc1 to have a lower LogP value.,CS(=O)(=O)c1ccc(Cc2nnc(NC(=O)C34CC5CC(CC(C5)C3)C4)o2)cc1,3.2188000000000017
148949,Please optimize the molecule CCc1nc(NC(=O)CCc2nncn2-c2ccccc2)sc1C to have a higher LogP value.,CCc1nc(NC(=O)CCc2nncn2-c2ccccc2)sc1C,3.1659200000000016
226746,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc2c(c1)C[C@@H](C)N2C(=O)C1CC1 to decrease its LogP value.,Cc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc2c(c1)C[C@@H](C)N2C(=O)C1CC1,3.6431200000000024
21869,Please optimize the molecule CCC(=O)N1CC[C@@H](C(=O)N(C[C@@H]2CCCCO2)C(C)C)C1 to have a higher LogP value.,CCC(=O)N1CC[C@@H](C(=O)N(C[C@@H]2CCCCO2)C(C)C)C1,2.0509999999999997
14937,Please modify the molecule CCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@@H]2c2cccc(OC)c2OC)C1=O to decrease its LogP value.,CCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@@H]2c2cccc(OC)c2OC)C1=O,3.280000000000002
245159,Modify the molecule CC(C)N1C(=O)Cc2ccccc2[C@@H]1C(=O)NCc1ccc(N(C)C)cc1 to decrease its LogP value.,CC(C)N1C(=O)Cc2ccccc2[C@@H]1C(=O)NCc1ccc(N(C)C)cc1,2.903200000000002
213509,Modify the molecule CCCn1c(S(=O)(=O)Cc2csc(-c3ccc(Cl)cc3)n2)n[nH]c1=O to have a higher LogP value.,CCCn1c(S(=O)(=O)Cc2csc(-c3ccc(Cl)cc3)n2)n[nH]c1=O,2.7322000000000006
112128,Please optimize the molecule CC1(C)CCN(c2nc(C[NH3+])cc3ccccc23)C1 to have a higher LogP value.,CC1(C)CCN(c2nc(C[NH3+])cc3ccccc23)C1,2.212999999999999
113631,Optimize the molecule CCc1ccccc1N1Cc2ccc(N)cc2C1 to have a lower LogP value.,CCc1ccccc1N1Cc2ccc(N)cc2C1,3.351400000000001
112706,Please optimize the molecule CCS(=O)(=O)[N-]c1ccc(NC(=O)NC2CCCCC2)cc1C to have a lower LogP value.,CCS(=O)(=O)[N-]c1ccc(NC(=O)NC2CCCCC2)cc1C,3.804120000000003
221406,Please optimize the molecule CCN(CC)c1nc2sc(C(=O)Nc3cccnc3-n3cccn3)cc2s1 to have a higher LogP value.,CCN(CC)c1nc2sc(C(=O)Nc3cccnc3-n3cccn3)cc2s1,4.0370000000000035
208255,Please modify the molecule O=S(=O)(Cc1ccccc1Cl)NCC[NH+]1CCN(c2ccccc2F)CC1 to increase its LogP value.,O=S(=O)(Cc1ccccc1Cl)NCC[NH+]1CCN(c2ccccc2F)CC1,1.3036000000000003
62547,Please optimize the molecule FC(F)(F)c1ccccc1CNCc1cccc(CN2CCOCC2)c1 to have a higher LogP value.,FC(F)(F)c1ccccc1CNCc1cccc(CN2CCOCC2)c1,3.8274000000000026
87960,Optimize the molecule C[NH+]1CCN(c2ncnc(Nc3ccc(OC(F)(F)F)cc3)c2[N+](=O)[O-])CC1 to have a lower LogP value.,C[NH+]1CCN(c2ncnc(Nc3ccc(OC(F)(F)F)cc3)c2[N+](=O)[O-])CC1,1.3617
148513,Optimize the molecule Cc1cc(NC(=O)c2cccc3ccccc23)sn1 to have a higher LogP value.,Cc1cc(NC(=O)c2cccc3ccccc23)sn1,3.8570200000000012
209848,Optimize the molecule Cc1cc(C)n2nc(SCC(=O)c3ccc[nH]3)nc2n1 to have a higher LogP value.,Cc1cc(C)n2nc(SCC(=O)c3ccc[nH]3)nc2n1,2.04424
147194,Optimize the molecule CC(C)C[C@@H]1NC(=O)C(C)(C)N(Cc2nccs2)C1=O to have a lower LogP value.,CC(C)C[C@@H]1NC(=O)C(C)(C)N(Cc2nccs2)C1=O,1.7947999999999995
173871,Optimize the molecule CCc1nn(C)cc1NC(=O)c1cc(C)cc(Br)c1O to have a lower LogP value.,CCc1nn(C)cc1NC(=O)c1cc(C)cc(Br)c1O,3.0113200000000018
206612,Modify the molecule Cc1ccc2c(c1)N(C(=O)c1cc(C(C)C)[nH]n1)C[C@H](C)O2 to decrease its LogP value.,Cc1ccc2c(c1)N(C(=O)c1cc(C(C)C)[nH]n1)C[C@H](C)O2,3.2692200000000007
227086,Optimize the molecule COc1ccccc1C(=O)NC(=S)N(C)C1CCCCC1 to have a higher LogP value.,COc1ccccc1C(=O)NC(=S)N(C)C1CCCCC1,2.974400000000001
56973,Please optimize the molecule COC(=O)Cc1n[nH]c2c1[C@@H](c1ccc(OC)c(Br)c1)C(C#N)=C(N)O2 to have a lower LogP value.,COC(=O)Cc1n[nH]c2c1[C@@H](c1ccc(OC)c(Br)c1)C(C#N)=C(N)O2,2.11448
124827,Modify the molecule COC(=O)[C@H]1CCCCC[C@H]1NC(=O)Nc1ccccc1N(C)C to have a lower LogP value.,COC(=O)[C@H]1CCCCC[C@H]1NC(=O)Nc1ccccc1N(C)C,2.9960000000000013
62533,Please modify the molecule C[C@@H]1CCC[C@@]([C@H](O)[C@@H]2CCc3cccnc32)([NH+](C)C)C1 to decrease its LogP value.,C[C@@H]1CCC[C@@]([C@H](O)[C@@H]2CCc3cccnc32)([NH+](C)C)C1,1.5656999999999999
119351,Please optimize the molecule COc1ccc(-c2noc(C[NH2+]C3CCCCC3)n2)cc1 to have a lower LogP value.,COc1ccc(-c2noc(C[NH2+]C3CCCCC3)n2)cc1,2.1413
36956,Please modify the molecule CCOC(=O)c1nc(Nc2ccsc2C(=O)OC)c2c(C)noc2n1 to decrease its LogP value.,CCOC(=O)c1nc(Nc2ccsc2C(=O)OC)c2c(C)noc2n1,2.6946200000000005
140907,Please optimize the molecule CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCCCCCC1 to have a lower LogP value.,CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCCCCCC1,2.4261
154169,Please optimize the molecule CCC1CCC(NC(=O)CNCC(F)(F)F)(C(=O)[O-])CC1 to have a higher LogP value.,CCC1CCC(NC(=O)CNCC(F)(F)F)(C(=O)[O-])CC1,0.3434
100993,Modify the molecule C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1,2.646300000000001
79098,Please modify the molecule COc1ccc(C[NH2+]Cc2cc(F)c(F)c(F)c2)cc1OC to increase its LogP value.,COc1ccc(C[NH2+]Cc2cc(F)c(F)c(F)c2)cc1OC,2.3847000000000005
188995,Modify the molecule O=C(c1cccnc1)N1CCN(CC2=c3ccccc3=[NH+]C2)CC1 to increase its LogP value.,O=C(c1cccnc1)N1CCN(CC2=c3ccccc3=[NH+]C2)CC1,-1.5958999999999968
160361,Please modify the molecule COc1cccc(-c2cc(C(=O)NCC#CCOc3cccc4cccnc34)[nH]n2)c1 to increase its LogP value.,COc1cccc(-c2cc(C(=O)NCC#CCOc3cccc4cccnc34)[nH]n2)c1,3.4457000000000013
146260,Optimize the molecule NS(=O)(=O)c1ccc(CNC(=O)NCCc2cccc(F)c2)cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(CNC(=O)NCCc2cccc(F)c2)cc1,1.5149999999999997
11643,Modify the molecule COc1ccc(NC(=O)c2nnc(C(=O)NCc3ccc(N(C)C)cc3)s2)cc1 to have a lower LogP value.,COc1ccc(NC(=O)c2nnc(C(=O)NCc3ccc(N(C)C)cc3)s2)cc1,2.795000000000001
171607,Please optimize the molecule Cc1nn(-c2ccccc2)c(CN2C(=O)N[C@@]3(CCSC3)C2=O)c1C#N to have a lower LogP value.,Cc1nn(-c2ccccc2)c(CN2C(=O)N[C@@]3(CCSC3)C2=O)c1C#N,1.9799000000000002
213266,Please modify the molecule CCCC(CCC)CC(=O)Nc1ccc2oc(=O)n(C)c2c1 to decrease its LogP value.,CCCC(CCC)CC(=O)Nc1ccc2oc(=O)n(C)c2c1,3.6765000000000025
88864,Modify the molecule CC[C@H](CS)COc1ccc(F)cc1 to have a lower LogP value.,CC[C@H](CS)COc1ccc(F)cc1,3.1605000000000016
240889,Please optimize the molecule CC1(C)CC(=O)C2=C(C1)Nc1nc(Cc3ccccc3)nn1[C@@H]2c1ccc2c(c1)OCCCO2 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)Nc1nc(Cc3ccccc3)nn1[C@@H]2c1ccc2c(c1)OCCCO2,4.688300000000004
107434,Please optimize the molecule CN(C(=O)c1ccc2ccc(Cl)cc2n1)c1ccc(F)c(F)c1 to have a lower LogP value.,CN(C(=O)c1ccc2ccc(Cl)cc2n1)c1ccc(F)c(F)c1,4.443000000000001
125041,Please optimize the molecule C[C@H]1CN(c2nc([O-])c3c(n2)C[NH+](Cc2ccc(N4CCOCC4)cc2)CC3)C[C@@H](C)O1 to have a higher LogP value.,C[C@H]1CN(c2nc([O-])c3c(n2)C[NH+](Cc2ccc(N4CCOCC4)cc2)CC3)C[C@@H](C)O1,0.1416000000000044
111456,Modify the molecule COC(=O)C[C@H](NS(=O)(=O)c1c[nH]c2nccc(Cl)c12)c1ccccc1 to have a lower LogP value.,COC(=O)C[C@H](NS(=O)(=O)c1c[nH]c2nccc(Cl)c12)c1ccccc1,2.7990000000000013
74813,Modify the molecule CC[C@H](COC)N[C@H]1CC[NH+](C)[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CC[C@H](COC)N[C@H]1CC[NH+](C)[C@@H]1c1ccc(Cl)cc1,1.6827000000000003
211870,Please optimize the molecule Cc1nc(-c2ccccc2)sc1CNC(=O)NCC(C)(C)[NH+](C)C to have a higher LogP value.,Cc1nc(-c2ccccc2)sc1CNC(=O)NCC(C)(C)[NH+](C)C,1.84082
199553,Modify the molecule C/C(=N\NC(=O)CNc1cccc(Br)c1)c1ccc(Br)cc1 to increase its LogP value.,C/C(=N\NC(=O)CNc1cccc(Br)c1)c1ccc(Br)cc1,4.163900000000003
174809,Modify the molecule C[C@H](NC(=O)Nc1ccc(C(N)=O)cc1F)c1ccc(Cl)cc1 to increase its LogP value.,C[C@H](NC(=O)Nc1ccc(C(N)=O)cc1F)c1ccc(Cl)cc1,3.460700000000001
193407,Optimize the molecule O=C(COc1ccccc1F)Nc1cccc(S(=O)(=O)N2CCCC2)c1 to have a higher LogP value.,O=C(COc1ccccc1F)Nc1cccc(S(=O)(=O)N2CCCC2)c1,2.627700000000001
110747,Modify the molecule Cc1cc(NCCCc2c(C)n[nH]c2C)n2nc(C)cc2n1 to increase its LogP value.,Cc1cc(NCCCc2c(C)n[nH]c2C)n2nc(C)cc2n1,2.730780000000001
242599,Please optimize the molecule Cc1ccc(N2C[C@@H](C(=O)O[C@H](C)C(=O)c3ccccc3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(N2C[C@@H](C(=O)O[C@H](C)C(=O)c3ccccc3)CC2=O)cc1,3.1625200000000016
67336,Optimize the molecule Cc1ccc(C(=O)c2oc3ccccc3c2NC(=O)c2cc3occc3n2C)cc1 to have a lower LogP value.,Cc1ccc(C(=O)c2oc3ccccc3c2NC(=O)c2cc3occc3n2C)cc1,5.309220000000003
75641,Optimize the molecule O=C1CN(C(=O)c2ccccn2)C[C@@H](OCc2cccnc2)CN1CC1CCOCC1 to have a higher LogP value.,O=C1CN(C(=O)c2ccccn2)C[C@@H](OCc2cccnc2)CN1CC1CCOCC1,1.7730000000000001
141246,Optimize the molecule Cc1nc2ccc(N[C@@H](C)C[C@H]3CCCCC[NH2+]3)cc2s1 to have a higher LogP value.,Cc1nc2ccc(N[C@@H](C)C[C@H]3CCCCC[NH2+]3)cc2s1,3.3012200000000007
133165,Please optimize the molecule COCC[NH+]1CCC[C@@H](CN(C)c2nc3c(s2)c(C)nn3C)C1 to have a higher LogP value.,COCC[NH+]1CCC[C@@H](CN(C)c2nc3c(s2)c(C)nn3C)C1,0.7157200000000008
118472,Please modify the molecule C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CCl to increase its LogP value.,C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CCl,2.0313
159314,Modify the molecule CCN(CC)c1ccc(/C=C(/C#N)c2nc3cccc(C)c3[nH]2)cc1 to have a lower LogP value.,CCN(CC)c1ccc(/C=C(/C#N)c2nc3cccc(C)c3[nH]2)cc1,4.781700000000003
110043,Modify the molecule C[C@H]1CCC[C@@H](C[NH2+]CC(C)(C)C[C@@H](C)O)C1 to decrease its LogP value.,C[C@H]1CCC[C@@H](C[NH2+]CC(C)(C)C[C@@H](C)O)C1,2.1731999999999996
217825,Modify the molecule O=[N+]([O-])c1ccc(CSc2nc3cc(Cl)ccc3o2)cc1 to increase its LogP value.,O=[N+]([O-])c1ccc(CSc2nc3cc(Cl)ccc3o2)cc1,4.681700000000003
212286,Modify the molecule Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12 to decrease its LogP value.,Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12,3.1907200000000007
196456,Modify the molecule CCCc1noc(Cn2nc(C(C)(C)C)ccc2=O)n1 to increase its LogP value.,CCCc1noc(Cn2nc(C(C)(C)C)ccc2=O)n1,1.9246
239602,Modify the molecule COc1ccc(NC(=O)c2nnc([C@@H]3CCCN(C(=O)Nc4cc(C)ccc4C)C3)s2)cc1 to have a higher LogP value.,COc1ccc(NC(=O)c2nnc([C@@H]3CCCN(C(=O)Nc4cc(C)ccc4C)C3)s2)cc1,4.827340000000004
119245,Optimize the molecule CNc1cc(COc2ccccc2OC)ccc1[N+](=O)[O-] to have a lower LogP value.,CNc1cc(COc2ccccc2OC)ccc1[N+](=O)[O-],3.2241000000000017
207601,Please modify the molecule CC[NH+](CC)CCCn1c([C@@H](C)O)nc2ccc(Cl)cc21 to increase its LogP value.,CC[NH+](CC)CCCn1c([C@@H](C)O)nc2ccc(Cl)cc21,2.0578000000000003
83379,Modify the molecule O=C(NCc1ccco1)[C@H]1C[NH+]2CC[C@@H]1C[C@@H]2Cn1cc(C2(O)CCCC2)nn1 to have a lower LogP value.,O=C(NCc1ccco1)[C@H]1C[NH+]2CC[C@@H]1C[C@@H]2Cn1cc(C2(O)CCCC2)nn1,0.24240000000000061
145036,Please optimize the molecule CC[C@H](NC(=O)NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccc(Br)cc1 to have a higher LogP value.,CC[C@H](NC(=O)NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccc(Br)cc1,4.574200000000005
31091,Modify the molecule CCCS(=O)(=O)N1CCC[C@@H]1C(=O)Oc1ccc(C)c(C)c1 to decrease its LogP value.,CCCS(=O)(=O)N1CCC[C@@H]1C(=O)Oc1ccc(C)c(C)c1,2.4130400000000005
137925,Modify the molecule Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1 to decrease its LogP value.,Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1,1.1834
157687,Please optimize the molecule CCCNC(=O)[C@H](C)NC(=O)c1ccc(-n2cccc2)cc1 to have a higher LogP value.,CCCNC(=O)[C@H](C)NC(=O)c1ccc(-n2cccc2)cc1,2.1217999999999995
85605,Modify the molecule Cc1cc(C)c(NNC(=O)c2coc(-c3ccccc3)n2)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(NNC(=O)c2coc(-c3ccccc3)n2)c(C)c1,4.023760000000002
196905,Modify the molecule CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1cnn(C)c1 to have a lower LogP value.,CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1cnn(C)c1,1.5480999999999998
202349,Optimize the molecule COc1ccc(C(=O)NC(=S)Nc2ccc(-c3ccc(CO)o3)c(C)c2)cc1Cl to have a higher LogP value.,COc1ccc(C(=O)NC(=S)Nc2ccc(-c3ccc(CO)o3)c(C)c2)cc1Cl,4.536120000000003
20437,Modify the molecule Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1 to have a higher LogP value.,Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1,1.9441200000000003
60979,Modify the molecule Cc1ccsc1CNC(=O)NCc1ccc(NC(=O)NC(C)C)cc1 to increase its LogP value.,Cc1ccsc1CNC(=O)NCc1ccc(NC(=O)NC(C)C)cc1,3.585820000000002
68920,Optimize the molecule ClC1=CC2=CC=N[C@@H]2C(Cl)=C1 to have a lower LogP value.,ClC1=CC2=CC=N[C@@H]2C(Cl)=C1,2.6248000000000005
60484,Optimize the molecule C[C@@H]1CCc2sc(C(=O)NNC(=O)C3C[C@@H](C)O[C@H](C)C3)cc2C1 to have a higher LogP value.,C[C@@H]1CCc2sc(C(=O)NNC(=O)C3C[C@@H](C)O[C@H](C)C3)cc2C1,2.8375000000000012
62950,Please optimize the molecule CC[C@@H](C(=O)N1CCC(n2nnc3c(=O)nc(C)[nH]c32)CC1)c1ccccc1 to have a higher LogP value.,CC[C@@H](C(=O)N1CCC(n2nnc3c(=O)nc(C)[nH]c32)CC1)c1ccccc1,2.180319999999999
182952,Optimize the molecule COC(=O)c1ccccc1N(C)S(=O)(=O)c1ccc(C(F)(F)F)cc1 to have a higher LogP value.,COC(=O)c1ccccc1N(C)S(=O)(=O)c1ccc(C(F)(F)F)cc1,3.3171000000000017
162718,Please optimize the molecule CC1=C2[C@H](c3ccc(C(F)(F)F)cc3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 to have a lower LogP value.,CC1=C2[C@H](c3ccc(C(F)(F)F)cc3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1,1.797399999999999
173103,Please optimize the molecule CC(C)Cc1noc(C[NH+](C)[C@H](C)C(=O)Nc2nccs2)n1 to have a higher LogP value.,CC(C)Cc1noc(C[NH+](C)[C@H](C)C(=O)Nc2nccs2)n1,0.7664999999999993
105887,Modify the molecule CCCn1c(=O)c2cc(Cl)ccc2n2c(SCC(=O)Nc3ccc4c(c3)OCCO4)nnc12 to have a higher LogP value.,CCCn1c(=O)c2cc(Cl)ccc2n2c(SCC(=O)Nc3ccc4c(c3)OCCO4)nnc12,3.6096000000000013
112944,Modify the molecule C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C to increase its LogP value.,C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C,2.3150000000000004
75564,Modify the molecule O=C(NCCC(=O)N1CCN(Cc2cccc3cccnc23)CC1)c1ccc(F)cc1F to have a lower LogP value.,O=C(NCCC(=O)N1CCN(Cc2cccc3cccnc23)CC1)c1ccc(F)cc1F,2.9773000000000014
242924,Please optimize the molecule CC[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(OC(F)(F)F)c1 to have a lower LogP value.,CC[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(OC(F)(F)F)c1,3.6087000000000016
239164,Modify the molecule COCCn1c(C)cc(CN2CCO[C@H](c3cccc(OC)c3)C2)c1C to decrease its LogP value.,COCCn1c(C)cc(CN2CCO[C@H](c3cccc(OC)c3)C2)c1C,3.333440000000002
112497,Modify the molecule CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2c1CCN(Cc1ccccc1)C2 to increase its LogP value.,CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2c1CCN(Cc1ccccc1)C2,5.001900000000005
77537,Please optimize the molecule COc1cccc(NC(=O)[C@H](C)[NH+](C)CC(=O)N2CCOCC2)c1 to have a higher LogP value.,COc1cccc(NC(=O)[C@H](C)[NH+](C)CC(=O)N2CCOCC2)c1,-0.6042999999999976
120444,Please modify the molecule CN(CC(=O)Nc1c(Cl)cccc1Cl)S(=O)(=O)c1ccc(C#N)cc1 to increase its LogP value.,CN(CC(=O)Nc1c(Cl)cccc1Cl)S(=O)(=O)c1ccc(C#N)cc1,3.1242800000000006
32449,Optimize the molecule Cc1ccc(CC(=O)N2CCC[C@H](N3CCNC3=O)C2)cc1O to have a lower LogP value.,Cc1ccc(CC(=O)N2CCC[C@H](N3CCNC3=O)C2)cc1O,1.2593199999999998
10459,Please optimize the molecule COC(=O)C1CCN(C(=O)c2cc(C3CC3)nc3c(C)cc(C)cc23)CC1 to have a lower LogP value.,COC(=O)C1CCN(C(=O)c2cc(C3CC3)nc3c(C)cc(C)cc23)CC1,3.754240000000003
93433,Optimize the molecule C[C@H]1CC(C)(C)C[C@](CO)([NH2+]Cc2nnc(C(C)(C)C)o2)C1 to have a lower LogP value.,C[C@H]1CC(C)(C)C[C@](CO)([NH2+]Cc2nnc(C(C)(C)C)o2)C1,2.0078
161702,Modify the molecule Cc1csc(CNC(=O)c2ccccc2SCc2csc(C)n2)n1 to have a higher LogP value.,Cc1csc(CNC(=O)c2ccccc2SCc2csc(C)n2)n1,4.438740000000004
233482,Optimize the molecule CC(C)C[NH2+]CC[C@](C)(O)Cc1cc(F)cc(Br)c1 to have a higher LogP value.,CC(C)C[NH2+]CC[C@](C)(O)Cc1cc(F)cc(Br)c1,2.491200000000001
180586,Please optimize the molecule COc1ccccc1O[C@@H](C)CNC(=O)c1cc(C)n(-c2ccccc2)n1 to have a lower LogP value.,COc1ccccc1O[C@@H](C)CNC(=O)c1cc(C)n(-c2ccccc2)n1,3.3866200000000015
31065,Optimize the molecule CC(C)(C)c1ccc(NC(=O)CN2C(=O)[C@H]3C[C@H]3C2=O)cc1 to have a lower LogP value.,CC(C)(C)c1ccc(NC(=O)CN2C(=O)[C@H]3C[C@H]3C2=O)cc1,1.9275
154400,Modify the molecule CCC[NH2+][C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CN(CC)CCO1 to decrease its LogP value.,CCC[NH2+][C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CN(CC)CCO1,2.728600000000001
50221,Please modify the molecule C[NH2+][C@]1(C(=O)OC)CCC[C@H](Oc2ccc(F)cc2)C1 to decrease its LogP value.,C[NH2+][C@]1(C(=O)OC)CCC[C@H](Oc2ccc(F)cc2)C1,1.2520999999999993
163985,Please optimize the molecule O=Cc1ccc(OC[C@H]2CCOC2)cn1 to have a higher LogP value.,O=Cc1ccc(OC[C@H]2CCOC2)cn1,1.3094000000000001
121698,Please optimize the molecule CC[NH2+][C@@H](C)c1ccnc(N(C)CCO)c1 to have a higher LogP value.,CC[NH2+][C@@H](C)c1ccnc(N(C)CCO)c1,0.15440000000000015
57438,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)Nc1ccc(Br)cn1)C2 to increase its LogP value.,Cc1cc2c(cc1C)O[C@@H](C(=O)Nc1ccc(Br)cn1)C2,3.4031400000000014
131696,Modify the molecule CC[C@H](C)[C@@H](CCl)Cc1cccc(F)c1 to have a higher LogP value.,CC[C@H](C)[C@@H](CCl)Cc1cccc(F)c1,4.269300000000004
216188,Please optimize the molecule C[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=O)[C@H]1CC(=O)N(C)C1 to have a lower LogP value.,C[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=O)[C@H]1CC(=O)N(C)C1,1.5924999999999998
155456,Modify the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CCO[C@@H](c2ccccc2)C1 to have a higher LogP value.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CCO[C@@H](c2ccccc2)C1,3.650420000000002
167442,Optimize the molecule CC[C@H](C)NC(=O)NC1[C@@H](C)CCC[C@H]1C to have a lower LogP value.,CC[C@H](C)NC(=O)NC1[C@@H](C)CCC[C@H]1C,2.908800000000001
53704,Optimize the molecule CCCN(c1cccc(Cl)c1/C=C/C(=O)[O-])C1CC1 to have a higher LogP value.,CCCN(c1cccc(Cl)c1/C=C/C(=O)[O-])C1CC1,2.4819000000000004
182268,Please optimize the molecule CC(C)Cn1nnnc1SCC(=O)c1ccc(Cl)s1 to have a higher LogP value.,CC(C)Cn1nnnc1SCC(=O)c1ccc(Cl)s1,3.019000000000002
192897,Please optimize the molecule CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1 to have a higher LogP value.,CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1,1.659100000000001
98881,Optimize the molecule C[NH+](C)[C@H]1CCN(C(=O)c2ccncc2/C=C/C(=O)[O-])C1 to have a higher LogP value.,C[NH+](C)[C@H]1CCN(C(=O)c2ccncc2/C=C/C(=O)[O-])C1,-1.7962999999999956
241283,Modify the molecule Cc1nc(CC(=O)N[C@H](c2ccccc2)c2ccc(Cl)cc2)cs1 to decrease its LogP value.,Cc1nc(CC(=O)N[C@H](c2ccccc2)c2ccc(Cl)cc2)cs1,4.553220000000003
92205,Modify the molecule C#CCN1CCN(C(=O)CNc2cccc(C(=O)NCCO)c2C)CC1 to have a higher LogP value.,C#CCN1CCN(C(=O)CNc2cccc(C(=O)NCCO)c2C)CC1,-0.09357999999999866
153108,Optimize the molecule C#Cc1cccc(NCC(=O)Nc2ccc3c(c2)OCO3)c1 to have a lower LogP value.,C#Cc1cccc(NCC(=O)Nc2ccc3c(c2)OCO3)c1,2.4472000000000005
137262,Please modify the molecule COCCNC(=O)[C@H](C)Sc1ncn(-c2ccccc2)n1 to increase its LogP value.,COCCNC(=O)[C@H](C)Sc1ncn(-c2ccccc2)n1,1.5104999999999995
226700,Please optimize the molecule CC(C)c1nc(N2CCC(C)(C)CC2)sc1C=O to have a higher LogP value.,CC(C)c1nc(N2CCC(C)(C)CC2)sc1C=O,3.7054000000000027
114912,Modify the molecule CCO[C@H](CC)C(=O)Nc1cccc(-c2ncc(C)o2)c1 to increase its LogP value.,CCO[C@H](CC)C(=O)Nc1cccc(-c2ncc(C)o2)c1,3.403620000000002
25675,Please optimize the molecule CON(C)C(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C to have a higher LogP value.,CON(C)C(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C,1.7957999999999998
184456,Modify the molecule Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(=O)NCC(C)(C)O to have a lower LogP value.,Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(=O)NCC(C)(C)O,3.6380200000000023
246757,Please modify the molecule O=C(CSc1nnc(-c2ccncc2)n1-n1cccc1)Nc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C(CSc1nnc(-c2ccncc2)n1-n1cccc1)Nc1cccc(C(F)(F)F)c1,4.202600000000003
59402,Modify the molecule CCc1noc(CC)c1CC(=O)N1[C@@H](C)C[C@H](c2ccccc2)[C@@H]1C to decrease its LogP value.,CCc1noc(CC)c1CC(=O)N1[C@@H](C)C[C@H](c2ccccc2)[C@@H]1C,4.135000000000003
12452,Please optimize the molecule CN(CCc1ccccn1)[C@@H]1CCC[C@H]([NH3+])C1 to have a lower LogP value.,CN(CCc1ccccn1)[C@@H]1CCC[C@H]([NH3+])C1,1.109
95087,Optimize the molecule O=C(NCCC(=O)N1CCCC1)N[C@H]1CCO[C@@H]1c1ccccc1 to have a lower LogP value.,O=C(NCCC(=O)N1CCCC1)N[C@H]1CCO[C@@H]1c1ccccc1,1.8282999999999998
76968,Optimize the molecule C[NH2+][C@H](c1ccc2c(c1)CCCC(=O)N2)c1cscc1C to have a higher LogP value.,C[NH2+][C@H](c1ccc2c(c1)CCCC(=O)N2)c1cscc1C,2.613920000000001
195597,Please modify the molecule CCOCC(=O)N1CC[C@H]2CC[C@@H](C1)[NH+]2C to increase its LogP value.,CCOCC(=O)N1CC[C@H]2CC[C@@H](C1)[NH+]2C,-0.6990999999999972
195503,Modify the molecule COc1ccc(N2C(=O)CN(CCc3ccccc3)[C@H]3CS(=O)(=O)C[C@H]32)cc1 to increase its LogP value.,COc1ccc(N2C(=O)CN(CCc3ccccc3)[C@H]3CS(=O)(=O)C[C@H]32)cc1,1.7520999999999998
203465,Please modify the molecule C[C@@H]1CCCN(C(=O)C2CCN(Cn3nc(Nc4ccccc4F)sc3=S)CC2)C1 to increase its LogP value.,C[C@@H]1CCCN(C(=O)C2CCN(Cn3nc(Nc4ccccc4F)sc3=S)CC2)C1,4.484790000000004
173938,Modify the molecule CC[NH+](CC)CCN1C(=O)c2oc3ccc(F)cc3c(=O)c2[C@H]1c1cccc(Cl)c1 to decrease its LogP value.,CC[NH+](CC)CCN1C(=O)c2oc3ccc(F)cc3c(=O)c2[C@H]1c1cccc(Cl)c1,3.0554000000000014
245270,Modify the molecule Cc1ccccc1-c1nc(CS(=O)(=O)CC(=O)N[C@@H]2CCCC[C@@H]2C)c(C)o1 to have a lower LogP value.,Cc1ccccc1-c1nc(CS(=O)(=O)CC(=O)N[C@@H]2CCCC[C@@H]2C)c(C)o1,3.5681400000000023
28043,Modify the molecule O=C(NN1CCCCC1)/C(=C/c1c([O-])on[n+]1-c1ccccc1)NC(=O)c1ccccc1 to have a lower LogP value.,O=C(NN1CCCCC1)/C(=C/c1c([O-])on[n+]1-c1ccccc1)NC(=O)c1ccccc1,1.3128999999999993
72707,Optimize the molecule C[C@H]1OCC[C@H]1C(=O)N1CCC(=Cc2cc(Cl)ccc2Cl)CC1 to have a higher LogP value.,C[C@H]1OCC[C@H]1C(=O)N1CCC(=Cc2cc(Cl)ccc2Cl)CC1,4.424200000000004
126515,Please modify the molecule O=C(CNc1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCCC1)N1CCc2ccccc21 to decrease its LogP value.,O=C(CNc1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCCC1)N1CCc2ccccc21,2.6990000000000007
108588,Modify the molecule C[C@H](NC(=O)NCCSc1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1 to have a higher LogP value.,C[C@H](NC(=O)NCCSc1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1,3.8960000000000035
218077,Modify the molecule Cc1c2c(=O)n(C)[nH]c2cc(=O)n1-c1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,Cc1c2c(=O)n(C)[nH]c2cc(=O)n1-c1ccc(Oc2ccccc2)cc1,3.1182200000000018
113413,Optimize the molecule Cc1ccc(-c2nc(CC[NH3+])n[nH]2)cc1 to have a higher LogP value.,Cc1ccc(-c2nc(CC[NH3+])n[nH]2)cc1,0.5645199999999997
33076,Please modify the molecule CC(C)N(C(=O)C[NH+]1CC[C@H]2CC[C@@H](C1)N2C)C(C)C to decrease its LogP value.,CC(C)N(C(=O)C[NH+]1CC[C@H]2CC[C@@H](C1)N2C)C(C)C,0.3832000000000022
62213,Modify the molecule O=C(CNC(=O)c1cnn2cc(Br)cnc12)Nc1cccnc1 to decrease its LogP value.,O=C(CNC(=O)c1cnn2cc(Br)cnc12)Nc1cccnc1,1.2552999999999996
99603,Optimize the molecule Brc1ccc(-c2cn3ccccc3n2)s1 to have a lower LogP value.,Brc1ccc(-c2cn3ccccc3n2)s1,3.8253000000000013
124501,Modify the molecule C[C@@H]1CCN(C(=O)OC(C)(C)C)c2nc(CCO)ccc21 to decrease its LogP value.,C[C@@H]1CCN(C(=O)OC(C)(C)C)c2nc(CCO)ccc21,2.8651000000000018
56724,Optimize the molecule c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1 to have a higher LogP value.,c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1,3.6465000000000023
97732,Optimize the molecule COc1ccc(N2CSC3=C(C#N)[C@@H](c4c(F)cccc4Cl)CC(=O)N3C2)c(OC)c1 to have a lower LogP value.,COc1ccc(N2CSC3=C(C#N)[C@@H](c4c(F)cccc4Cl)CC(=O)N3C2)c(OC)c1,4.715780000000004
71216,Optimize the molecule COc1cc(CCC(=O)Oc2cc(C)c3c(c2)O/C(=C\c2ccccc2Br)C3=O)on1 to have a higher LogP value.,COc1cc(CCC(=O)Oc2cc(C)c3c(c2)O/C(=C\c2ccccc2Br)C3=O)on1,4.908520000000003
28356,Modify the molecule COc1ccc(OC)c(NC(=O)[C@@H](C)OC(=O)c2ccc(F)cc2)c1 to decrease its LogP value.,COc1ccc(OC)c(NC(=O)[C@@H](C)OC(=O)c2ccc(F)cc2)c1,3.0269000000000013
169647,Please optimize the molecule CC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@@H]1S(C)(=O)=O to have a higher LogP value.,CC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@@H]1S(C)(=O)=O,0.6789999999999996
151245,Please optimize the molecule CC(=O)c1ccc(NC(=O)N[C@@H]2CCC[C@@H]2C)cc1C to have a higher LogP value.,CC(=O)c1ccc(NC(=O)N[C@@H]2CCC[C@@H]2C)cc1C,3.5077200000000026
147686,Modify the molecule C[C@@H]1C[C@]2(CC[NH2+]C[C@@H]2c2cccc(F)c2)CCO1 to decrease its LogP value.,C[C@@H]1C[C@]2(CC[NH2+]C[C@@H]2c2cccc(F)c2)CCO1,2.0617
191157,Please modify the molecule CCC[C@@H](O)c1ccn(CCN2CCOCC2)c1 to increase its LogP value.,CCC[C@@H](O)c1ccn(CCN2CCOCC2)c1,1.6538000000000002
83864,Please modify the molecule O=C(/C=C/NCc1ccc(Cl)cc1)c1cc(Cl)sc1Cl to increase its LogP value.,O=C(/C=C/NCc1ccc(Cl)cc1)c1cc(Cl)sc1Cl,5.194500000000002
151098,Modify the molecule Cc1nc2ccc(Cl)cc2cc1C(=O)N(C)Cc1ccc([C@@H]2C[C@H]2C)o1 to have a lower LogP value.,Cc1nc2ccc(Cl)cc2cc1C(=O)N(C)Cc1ccc([C@@H]2C[C@H]2C)o1,5.185220000000005
249034,Modify the molecule CCN(c1[nH+]cnc(N(C)C)c1N)c1cccc2ccccc12 to have a lower LogP value.,CCN(c1[nH+]cnc(N(C)C)c1N)c1cccc2ccccc12,2.8551
150225,Optimize the molecule COC(=O)CCC[C@@H]([NH3+])c1cc(C)c(Br)s1 to have a lower LogP value.,COC(=O)CCC[C@@H]([NH3+])c1cc(C)c(Br)s1,2.4453200000000006
163262,Optimize the molecule Cc1ccccc1OCCN(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1 to have a lower LogP value.,Cc1ccccc1OCCN(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,1.0808200000000006
70317,Please optimize the molecule COC(=O)[C@@H]1C(=O)[C@@]2(Cc3c(ccc4ccccc34)N(Cc3ccc(OC)cc3)C2)C(=O)CC1(C)C to have a higher LogP value.,COC(=O)[C@@H]1C(=O)[C@@]2(Cc3c(ccc4ccccc34)N(Cc3ccc(OC)cc3)C2)C(=O)CC1(C)C,4.754800000000005
232496,Please modify the molecule Cc1ccc2sc(N(CCN3CCOCC3)C(=O)c3cc([N+](=O)[O-])ccc3Cl)nc2c1C to increase its LogP value.,Cc1ccc2sc(N(CCN3CCOCC3)C(=O)c3cc([N+](=O)[O-])ccc3Cl)nc2c1C,4.453740000000003
3317,Please modify the molecule C[C@@H]([NH2+]C[C@]1(C)CCCO1)c1ccc2c(c1)CCC2 to decrease its LogP value.,C[C@@H]([NH2+]C[C@]1(C)CCCO1)c1ccc2c(c1)CCC2,2.3688000000000002
36090,Modify the molecule Cc1cc(CNC(=O)N[C@@](C)(CO)C2CCCCC2)no1 to decrease its LogP value.,Cc1cc(CNC(=O)N[C@@](C)(CO)C2CCCCC2)no1,2.1135199999999994
156639,Please modify the molecule CC(C)c1csc([C@@]2(N)CCCS[C@@H]2C)n1 to decrease its LogP value.,CC(C)c1csc([C@@]2(N)CCCS[C@@H]2C)n1,3.336000000000002
219319,Optimize the molecule CN1C[C@H](NC(=O)c2cc(Cl)ccc2O)CCC1=O to have a lower LogP value.,CN1C[C@H](NC(=O)c2cc(Cl)ccc2O)CCC1=O,1.3961999999999997
159017,Please modify the molecule Cc1ccc(S(=O)(=O)/N=C2\N=c3ccccc3=[NH+][C@@H]2Nc2ccc3c(c2)OCCO3)c(C)c1 to decrease its LogP value.,Cc1ccc(S(=O)(=O)/N=C2\N=c3ccccc3=[NH+][C@@H]2Nc2ccc3c(c2)OCCO3)c(C)c1,0.6336400000000002
47445,Optimize the molecule CSCc1nnc(SCc2ccccn2)o1 to have a higher LogP value.,CSCc1nnc(SCc2ccccn2)o1,2.6199000000000003
42784,Please optimize the molecule CCC(C)(C)C1CCC(NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)CC1 to have a lower LogP value.,CCC(C)(C)C1CCC(NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)CC1,3.363400000000002
156239,Please optimize the molecule Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c(Cl)c1 to have a higher LogP value.,Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c(Cl)c1,4.208520000000003
191612,Please modify the molecule COCC1CCN(C(=O)c2nn(-c3ccc(F)cc3)cc2[O-])CC1 to increase its LogP value.,COCC1CCN(C(=O)c2nn(-c3ccc(F)cc3)cc2[O-])CC1,1.5836000000000001
62140,Modify the molecule O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1 to have a higher LogP value.,O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1,1.738299999999999
195088,Please optimize the molecule O=C(NCCc1cccs1)c1cn[nH]c1-c1ccc([N+](=O)[O-])cc1 to have a higher LogP value.,O=C(NCCc1cccs1)c1cn[nH]c1-c1ccc([N+](=O)[O-])cc1,3.0189000000000012
28812,Optimize the molecule CCc1nn(C)c(OC)c1CNC(=O)c1ccccc1[S@](=O)CC to have a higher LogP value.,CCc1nn(C)c(OC)c1CNC(=O)c1ccccc1[S@](=O)CC,2.0486
247006,Please modify the molecule O=C(C[NH2+]Cc1ccco1)Nc1cccc(Br)c1 to increase its LogP value.,O=C(C[NH2+]Cc1ccco1)Nc1cccc(Br)c1,1.7442000000000002
230083,Optimize the molecule C[C@H]1CCCN(C(=O)c2ccc(F)c(S(=O)(=O)N3CCCCC3)c2)C1 to have a lower LogP value.,C[C@H]1CCCN(C(=O)c2ccc(F)c(S(=O)(=O)N3CCCCC3)c2)C1,2.8724000000000016
21227,Modify the molecule COc1ccc(/C=N/NC(=O)COc2ccccc2)cc1C to have a higher LogP value.,COc1ccc(/C=N/NC(=O)COc2ccccc2)cc1C,2.5327200000000003
75701,Modify the molecule Cc1ccc([C@@](C)(O)CNC(=O)N[C@@H](C)CCCO)o1 to decrease its LogP value.,Cc1ccc([C@@](C)(O)CNC(=O)N[C@@H](C)CCCO)o1,1.2557199999999997
64150,Modify the molecule c1ccc2c(C[NH+]3CC[C@H](Oc4cc[nH+]cc4)C3)coc2c1 to decrease its LogP value.,c1ccc2c(C[NH+]3CC[C@H](Oc4cc[nH+]cc4)C3)coc2c1,1.4830999999999992
228897,Modify the molecule CC(C)N1C(=O)c2[nH]nc(-c3ccc(Cl)cc3)c2[C@H]1c1cccc([N+](=O)[O-])c1 to have a lower LogP value.,CC(C)N1C(=O)c2[nH]nc(-c3ccc(Cl)cc3)c2[C@H]1c1cccc([N+](=O)[O-])c1,4.591900000000003
90034,Modify the molecule C[C@H]1CCN(C(=O)Nc2cccnc2Cl)C[C@H]1O to increase its LogP value.,C[C@H]1CCN(C(=O)Nc2cccnc2Cl)C[C@H]1O,1.9696000000000002
48717,Optimize the molecule CCn1/c(=N/C(=O)c2cccnc2Cl)[nH]c2cc(Cl)ccc21 to have a higher LogP value.,CCn1/c(=N/C(=O)c2cccnc2Cl)[nH]c2cc(Cl)ccc21,3.4322000000000017
12866,Please modify the molecule NC(=O)Nc1ccc(NC(=O)[C@H]2CCN(c3cc(F)cc(F)c3)C2=O)cc1 to increase its LogP value.,NC(=O)Nc1ccc(NC(=O)[C@H]2CCN(c3cc(F)cc(F)c3)C2=O)cc1,2.447000000000001
42363,Modify the molecule CN(C)C(=O)c1ccc(CSc2nncn2C2CC2)cc1 to increase its LogP value.,CN(C)C(=O)c1ccc(CSc2nncn2C2CC2)cc1,2.607100000000001
136327,Modify the molecule C[NH2+][C@H](C)c1cc(F)c(C)cc1SCCOC to increase its LogP value.,C[NH2+][C@H](C)c1cc(F)c(C)cc1SCCOC,2.1268200000000004
170070,Modify the molecule CCCCC(=O)Nc1ccc(NC(=O)c2cc(C)nc(N)n2)cc1 to have a higher LogP value.,CCCCC(=O)Nc1ccc(NC(=O)c2cc(C)nc(N)n2)cc1,2.74822
4948,Modify the molecule Cc1ccc(S(=O)(=O)NCCC(=O)Nc2ccc(F)cc2C)cc1C to decrease its LogP value.,Cc1ccc(S(=O)(=O)NCCC(=O)Nc2ccc(F)cc2C)cc1C,3.058060000000002
24599,Optimize the molecule COC(=O)[C@H](C)N(C(=O)CCC1CCCC1)[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,COC(=O)[C@H](C)N(C(=O)CCC1CCCC1)[C@@H]1CCS(=O)(=O)C1,1.534
176977,Please optimize the molecule Cc1csc(Sc2cncc(C(=O)[O-])n2)n1 to have a higher LogP value.,Cc1csc(Sc2cncc(C(=O)[O-])n2)n1,0.75622
67248,Modify the molecule N#C/C(=C/c1cccc(OC2CCCC2)c1)C(=O)[O-] to decrease its LogP value.,N#C/C(=C/c1cccc(OC2CCCC2)c1)C(=O)[O-],1.6648799999999992
219235,Optimize the molecule COc1cc(C)c(C[NH2+]Cc2cccc(C)c2)cc1OC to have a higher LogP value.,COc1cc(C)c(C[NH2+]Cc2cccc(C)c2)cc1OC,2.5842400000000003
205332,Optimize the molecule CN(C[C@@H](O)C1CC1)C(=O)CN(C)C(=O)c1ccc(Br)o1 to have a higher LogP value.,CN(C[C@@H](O)C1CC1)C(=O)CN(C)C(=O)c1ccc(Br)o1,1.3434000000000001
224550,Please modify the molecule Cc1ncsc1CCS(=O)(=O)[C@H](C)c1ccc(C(F)(F)F)cc1 to increase its LogP value.,Cc1ncsc1CCS(=O)(=O)[C@H](C)c1ccc(C(F)(F)F)cc1,4.188820000000003
197636,Please optimize the molecule C[C@H]1C[C@@H](C)C[NH+](Cc2c(O)ccc3c2O/C(=C/c2cccc([N+](=O)[O-])c2)C3=O)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)C[NH+](Cc2c(O)ccc3c2O/C(=C/c2cccc([N+](=O)[O-])c2)C3=O)C1,2.977400000000001
243210,Optimize the molecule C=Cc1ccc(CN2C(=O)N(c3ccc(CC)cc3)[C@@H]3CS(=O)(=O)C[C@H]32)cc1 to have a lower LogP value.,C=Cc1ccc(CN2C(=O)N(c3ccc(CC)cc3)[C@@H]3CS(=O)(=O)C[C@H]32)cc1,3.4998000000000022
243212,Please modify the molecule COC(=O)CCNC(=O)c1ccc(NC(=O)c2cc(F)c(F)cc2Cl)cc1 to increase its LogP value.,COC(=O)CCNC(=O)c1ccc(NC(=O)c2cc(F)c(F)cc2Cl)cc1,3.163400000000001
6860,Modify the molecule C[C@@H](C(=O)N(C)CC(=O)NC1CC1)[NH+](C)Cc1ccc(F)c(F)c1 to have a higher LogP value.,C[C@@H](C(=O)N(C)CC(=O)NC1CC1)[NH+](C)Cc1ccc(F)c(F)c1,0.10500000000000176
105222,Optimize the molecule CC(=O)c1c[nH]c(C(=O)Nc2cccc(COC[C@@H]3CCCCO3)c2)c1 to have a lower LogP value.,CC(=O)c1c[nH]c(C(=O)Nc2cccc(COC[C@@H]3CCCCO3)c2)c1,3.5553000000000026
114873,Optimize the molecule CCCc1cc(C(=O)Nc2ccc(Br)cn2)cs1 to have a lower LogP value.,CCCc1cc(C(=O)Nc2ccc(Br)cn2)cs1,4.110400000000002
181042,Modify the molecule CCOC[C@H](C)N1CCC[NH+]2CCC[C@@H]2C1 to increase its LogP value.,CCOC[C@H](C)N1CCC[NH+]2CCC[C@@H]2C1,0.16440000000000232
62704,Please modify the molecule O=C(COc1ccc2ccc(=O)oc2c1)N[C@@H]1COc2ccccc2C1 to increase its LogP value.,O=C(COc1ccc2ccc(=O)oc2c1)N[C@@H]1COc2ccccc2C1,2.2916999999999996
5978,Please optimize the molecule Cc1cnc(C(=O)N2CCN(Cc3cccc(-c4noc(-c5cccnc5)n4)c3)CC2)cn1 to have a lower LogP value.,Cc1cnc(C(=O)N2CCN(Cc3cccc(-c4noc(-c5cccnc5)n4)c3)CC2)cn1,2.8550200000000014
69495,Modify the molecule COc1cc(Cl)c(C)cc1NC(=O)CNc1ccccc1-n1cccn1 to decrease its LogP value.,COc1cc(Cl)c(C)cc1NC(=O)CNc1ccccc1-n1cccn1,3.893320000000002
82732,Please modify the molecule Cc1c(Cl)cccc1Nc1ncnc(NC[C@@H]2CCCO2)c1N to increase its LogP value.,Cc1c(Cl)cccc1Nc1ncnc(NC[C@@H]2CCCO2)c1N,3.3551200000000003
76098,Optimize the molecule O=C(CS[C@H](c1ccccc1)c1ccc(Cl)cc1)Nc1cccnc1 to have a lower LogP value.,O=C(CS[C@H](c1ccccc1)c1ccc(Cl)cc1)Nc1cccnc1,5.1963000000000035
77952,Modify the molecule Cc1cc(=O)oc2cc(OCCN3C[C@@H](C)OC[C@@H]3C)ccc12 to have a lower LogP value.,Cc1cc(=O)oc2cc(OCCN3C[C@@H](C)OC[C@@H]3C)ccc12,2.5894200000000005
140629,Optimize the molecule Cc1ccc([C@@]2(C)NC(=O)N(C[C@H](O)c3cc(C)ccc3C)C2=O)cc1 to have a lower LogP value.,Cc1ccc([C@@]2(C)NC(=O)N(C[C@H](O)c3cc(C)ccc3C)C2=O)cc1,3.1124600000000013
36164,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)c2nn(C)c3c2CS(=O)(=O)c2ccccc2-3)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)c2nn(C)c3c2CS(=O)(=O)c2ccccc2-3)C1,2.4925000000000006
46430,Please optimize the molecule Cc1ccccc1CCNC(=O)c1cccc2[nH]ccc12 to have a higher LogP value.,Cc1ccccc1CCNC(=O)c1cccc2[nH]ccc12,3.4488200000000013
102503,Please modify the molecule O=C(CC[NH+](CC1CC1)C1CCCCC1)N1CCCCC1 to decrease its LogP value.,O=C(CC[NH+](CC1CC1)C1CCCCC1)N1CCCCC1,2.0165999999999995
223430,Please optimize the molecule Cc1cc(Br)ccc1NC(=O)COc1ccc([N+](=O)[O-])cc1C to have a higher LogP value.,Cc1cc(Br)ccc1NC(=O)COc1ccc([N+](=O)[O-])cc1C,3.991640000000002
6053,Please modify the molecule C[C@@H]1CN(Cc2ccc(C3CC3)cc2)[C@H](C)C[NH2+]1 to increase its LogP value.,C[C@@H]1CN(Cc2ccc(C3CC3)cc2)[C@H](C)C[NH2+]1,1.72
118863,Modify the molecule Cc1ccc([C@H]2C[C@@H](c3cccc4ccccc34)n3ncnc3N2)cc1 to have a lower LogP value.,Cc1ccc([C@H]2C[C@@H](c3cccc4ccccc34)n3ncnc3N2)cc1,4.886020000000004
80999,Modify the molecule C[C@H](CS(C)(=O)=O)NC(=O)NCc1ccccc1OC(C)(C)C to decrease its LogP value.,C[C@H](CS(C)(=O)=O)NC(=O)NCc1ccccc1OC(C)(C)C,2.096199999999999
53670,Modify the molecule Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1 to have a lower LogP value.,Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1,2.5288400000000006
92368,Please modify the molecule CCCC(=O)NCc1ccc(Cn2ccnc2)cc1 to decrease its LogP value.,CCCC(=O)NCc1ccc(Cn2ccnc2)cc1,2.3477000000000006
32414,Please modify the molecule Cc1ccsc1CNC(=O)C[NH+]1CC(C)(C)C1(C)C to increase its LogP value.,Cc1ccsc1CNC(=O)C[NH+]1CC(C)(C)C1(C)C,1.3760199999999994
96760,Modify the molecule Cc1ccc(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])c(C)n1 to have a lower LogP value.,Cc1ccc(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])c(C)n1,2.9649400000000012
64018,Optimize the molecule CCCO[C@H]1CCCN(C(=O)COCc2ccccc2)CC1 to have a lower LogP value.,CCCO[C@H]1CCCN(C(=O)COCc2ccccc2)CC1,3.010900000000002
234758,Modify the molecule Cc1ccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)c(C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)c(C)c1,3.2247400000000015
16593,Modify the molecule CN(CCC(N)=S)C(=O)COc1cccc2ccccc12 to have a higher LogP value.,CN(CCC(N)=S)C(=O)COc1cccc2ccccc12,2.3532
223312,Please modify the molecule COc1ccc(CNC(=O)Cc2c(C)c3c(cc(C)c4c(C)c(C)oc43)oc2=O)cc1OC to increase its LogP value.,COc1ccc(CNC(=O)Cc2c(C)c3c(cc(C)c4c(C)c(C)oc43)oc2=O)cc1OC,4.648980000000003
205142,Modify the molecule Cc1cc(Cl)cc2sc(N)nc12 to decrease its LogP value.,Cc1cc(Cl)cc2sc(N)nc12,2.84032
49351,Please modify the molecule N#C[C@@H]1[C@@H]2C(=O)N(c3ccc(F)cc3)C(=O)[C@@H]2[C@@H]2c3ccccc3C=CN12 to increase its LogP value.,N#C[C@@H]1[C@@H]2C(=O)N(c3ccc(F)cc3)C(=O)[C@@H]2[C@@H]2c3ccccc3C=CN12,2.8646800000000017
75735,Optimize the molecule CC(C)Cc1nnc(NC(=O)[C@H]2NN(c3cccc(Cl)c3)C=CC2=O)s1 to have a lower LogP value.,CC(C)Cc1nnc(NC(=O)[C@H]2NN(c3cccc(Cl)c3)C=CC2=O)s1,2.8047000000000013
107297,Modify the molecule CCCc1noc(CN2CCc3cc(F)ccc3C2)n1 to have a higher LogP value.,CCCc1noc(CN2CCc3cc(F)ccc3C2)n1,2.719500000000001
49405,Modify the molecule CN(C[C@@H]1CCC[NH+]1C)S(=O)(=O)c1cc(CO)oc1Br to have a higher LogP value.,CN(C[C@@H]1CCC[NH+]1C)S(=O)(=O)c1cc(CO)oc1Br,-0.16799999999999965
99546,Optimize the molecule CC(C)C[NH+](C)CN1C(=O)N[C@]2(CCCN(Cc3ccccc3)C2)C1=O to have a lower LogP value.,CC(C)C[NH+](C)CN1C(=O)N[C@]2(CCCN(Cc3ccccc3)C2)C1=O,0.7012000000000018
92711,Optimize the molecule CSCCCCNC(=O)N(C)[C@@H](C)c1ccccn1 to have a lower LogP value.,CSCCCCNC(=O)N(C)[C@@H](C)c1ccccn1,2.927200000000001
241030,Modify the molecule CCOC(=O)C1=C(C)OC(N)=C(C#N)[C@H]1c1cc(Cn2cnc3ccccc32)cs1 to have a higher LogP value.,CCOC(=O)C1=C(C)OC(N)=C(C#N)[C@H]1c1cc(Cn2cnc3ccccc32)cs1,3.7908800000000022
43165,Modify the molecule CC[C@H](NC(=O)C[C@H](O)c1ccc(Cl)cc1)c1nccs1 to have a higher LogP value.,CC[C@H](NC(=O)C[C@H](O)c1ccc(Cl)cc1)c1nccs1,3.4875000000000025
23707,Please optimize the molecule CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1 to have a higher LogP value.,CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1,3.7332000000000027
34256,Modify the molecule CCCc1nnc(NC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1 to have a higher LogP value.,CCCc1nnc(NC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1,2.527400000000001
167994,Please optimize the molecule COc1cc(OC)cc(C(=O)Nc2ccc(-c3nc4cnccc4o3)c(O)c2)c1 to have a lower LogP value.,COc1cc(OC)cc(C(=O)Nc2ccc(-c3nc4cnccc4o3)c(O)c2)c1,3.8649000000000022
82349,Please optimize the molecule O=C([O-])c1cc(F)c(F)c(O)c1F to have a lower LogP value.,O=C([O-])c1cc(F)c(F)c(O)c1F,0.173
40664,Modify the molecule O=c1c([N+](=O)[O-])c(NC[C@@H](O)C[NH+]2CCc3ccccc3C2)nc2ccccn12 to decrease its LogP value.,O=c1c([N+](=O)[O-])c(NC[C@@H](O)C[NH+]2CCc3ccccc3C2)nc2ccccn12,0.01670000000000038
47142,Please optimize the molecule Brc1cc(CN[C@@H](c2ccccc2)c2ccccn2)cc2c1OCO2 to have a lower LogP value.,Brc1cc(CN[C@@H](c2ccccc2)c2ccccn2)cc2c1OCO2,4.452000000000003
17580,Modify the molecule C[C@H]1CC(NC(=O)Cc2ccccc2O)C[C@H](C)O1 to have a higher LogP value.,C[C@H]1CC(NC(=O)Cc2ccccc2O)C[C@H](C)O1,2.0069
14662,Modify the molecule CS(=O)(=O)c1cc(Cl)cnc1[C@H]1CCCN(C(=O)c2ccncc2)C1 to have a lower LogP value.,CS(=O)(=O)c1cc(Cl)cnc1[C@H]1CCCN(C(=O)c2ccncc2)C1,2.553300000000001
2502,Please modify the molecule Cc1nccn1-c1cc(N2CCC(C(=O)Nc3ccc(F)c(F)c3)CC2)ncn1 to decrease its LogP value.,Cc1nccn1-c1cc(N2CCC(C(=O)Nc3ccc(F)c(F)c3)CC2)ncn1,3.104020000000001
135507,Modify the molecule C[C@@H]1CCCC[C@@H]1[NH2+]CCN1C(=O)CCC1=O to have a higher LogP value.,C[C@@H]1CCCC[C@@H]1[NH2+]CCN1C(=O)CCC1=O,0.27749999999999986
126597,Modify the molecule CC(C)CCNC(=O)C(=O)Nc1cc(Br)c(=O)n(C)c1 to increase its LogP value.,CC(C)CCNC(=O)C(=O)Nc1cc(Br)c(=O)n(C)c1,1.2485999999999993
7106,Modify the molecule CCOC(=O)Cc1csc(Nc2cccc(Cl)c2)n1 to have a higher LogP value.,CCOC(=O)Cc1csc(Nc2cccc(Cl)c2)n1,3.6457000000000024
31209,Please optimize the molecule CC[C@@H]1c2ccsc2CCN1C(=O)CCc1c(C)nc(C)[nH]c1=O to have a lower LogP value.,CC[C@@H]1c2ccsc2CCN1C(=O)CCc1c(C)nc(C)[nH]c1=O,2.9168400000000005
23005,Optimize the molecule Cc1cnc(CCNC(=O)N(C)[C@@H](C)[C@H](C)c2ccc(Cl)cc2)s1 to have a higher LogP value.,Cc1cnc(CCNC(=O)N(C)[C@@H](C)[C@H](C)c2ccc(Cl)cc2)s1,4.4810200000000036
7215,Please modify the molecule C[C@@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(Br)c2)[C@@H]1C to increase its LogP value.,C[C@@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(Br)c2)[C@@H]1C,3.328500000000002
212303,Modify the molecule C=CCCCC(=O)[C@H]1CSCCS1 to have a lower LogP value.,C=CCCCC(=O)[C@H]1CSCCS1,2.7604000000000015
1806,Modify the molecule O=C(NCCc1cccc(O)c1)N1CCC[C@H]1CN1CCOCC1 to have a lower LogP value.,O=C(NCCc1cccc(O)c1)N1CCC[C@H]1CN1CCOCC1,1.4409
119461,Optimize the molecule COc1ccc(OC)c(CN(C)S(=O)(=O)c2cc(C)c(C)s2)c1 to have a higher LogP value.,COc1ccc(OC)c(CN(C)S(=O)(=O)c2cc(C)c(C)s2)c1,3.202840000000002
66973,Please modify the molecule Oc1ccc(-c2nc3ccccc3s2)cc1Cl to decrease its LogP value.,Oc1ccc(-c2nc3ccccc3s2)cc1Cl,4.322300000000001
61142,Modify the molecule CC(C)c1ccc(NC(=O)/C(N)=N\O)cc1 to increase its LogP value.,CC(C)c1ccc(NC(=O)/C(N)=N\O)cc1,1.4949
125139,Modify the molecule C[C@H]1CCC[C@H](C)N1C(=O)Cn1ccc(-c2ccccc2)n1 to have a lower LogP value.,C[C@H]1CCC[C@H](C)N1C(=O)Cn1ccc(-c2ccccc2)n1,3.3396000000000017
224894,Optimize the molecule Cc1cnccc1-n1nc(C(C)C)nc1-c1cnc2cccc(C)n2c1=O to have a higher LogP value.,Cc1cnccc1-n1nc(C(C)C)nc1-c1cnc2cccc(C)n2c1=O,3.077440000000001
194362,Modify the molecule NC(=O)c1ccc(NC(=O)Cn2ccc3cc(Cl)ccc32)cc1 to decrease its LogP value.,NC(=O)c1ccc(NC(=O)Cn2ccc3cc(Cl)ccc32)cc1,3.032300000000001
134315,Please optimize the molecule COc1ccc(Cc2nc(N)nc(C)c2C(=O)NN)cc1 to have a lower LogP value.,COc1ccc(Cc2nc(N)nc(C)c2C(=O)NN)cc1,0.5701200000000002
198111,Optimize the molecule C[C@@H](C(=O)NC(=O)NC(C)(C)C)N1CCN(c2ncccc2C#N)CC1 to have a lower LogP value.,C[C@@H](C(=O)NC(=O)NC(C)(C)C)N1CCN(c2ncccc2C#N)CC1,1.0880800000000002
36277,Optimize the molecule Cc1ccc([C@@H](C)NC(=O)Nc2ccccc2CC(N)=O)cc1F to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)Nc2ccccc2CC(N)=O)cc1F,3.044620000000001
13663,Modify the molecule CCOc1ccc(C=O)c(C)n1 to increase its LogP value.,CCOc1ccc(C=O)c(C)n1,1.6012199999999999
216626,Optimize the molecule Nc1cnc(-c2ccnc(N)n2)cn1 to have a higher LogP value.,Nc1cnc(-c2ccnc(N)n2)cn1,0.09799999999999998
175864,Optimize the molecule COC[C@@H](O)C[NH+]1CCC(N[C@H](C)c2cccc3ccccc23)CC1 to have a higher LogP value.,COC[C@@H](O)C[NH+]1CCC(N[C@H](C)c2cccc3ccccc23)CC1,1.5450000000000013
41207,Please modify the molecule CC(C)C(=O)N[C@H]1CCC[NH+]([C@@H]2CC[C@H](C)C2)C1 to decrease its LogP value.,CC(C)C(=O)N[C@H]1CCC[NH+]([C@@H]2CC[C@H](C)C2)C1,0.994500000000001
88040,Please optimize the molecule CCOc1ccccc1NC(=O)c1cccc(OC)c1 to have a higher LogP value.,CCOc1ccccc1NC(=O)c1cccc(OC)c1,3.3462000000000014
126992,Modify the molecule CNS(=O)(=O)c1ccc(CNC(=O)c2c(C)nn(C)c2C)cc1 to have a higher LogP value.,CNS(=O)(=O)c1ccc(CNC(=O)c2c(C)nn(C)c2C)cc1,0.8750399999999994
222320,Optimize the molecule CN(c1ccc2nnc(-c3ccccc3F)n2n1)[C@@H]1CCC[NH+](C)C1 to have a lower LogP value.,CN(c1ccc2nnc(-c3ccccc3F)n2n1)[C@@H]1CCC[NH+](C)C1,1.0436999999999996
226975,Please optimize the molecule COCCn1ccc2ccc(NC(=O)N3CCC[C@@H](C)[C@H]3CO)cc21 to have a higher LogP value.,COCCn1ccc2ccc(NC(=O)N3CCC[C@@H](C)[C@H]3CO)cc21,2.9124000000000017
214969,Please optimize the molecule COc1cc(CN2CCN(Cc3cnc(C4CC4)s3)CC2)cc(OC)c1 to have a higher LogP value.,COc1cc(CN2CCN(Cc3cnc(C4CC4)s3)CC2)cc(OC)c1,3.355500000000002
108843,Please optimize the molecule O=C(c1csc(-c2ccsc2)n1)N1CCO[C@@H]2CCCC[C@@H]21 to have a higher LogP value.,O=C(c1csc(-c2ccsc2)n1)N1CCO[C@@H]2CCCC[C@@H]21,3.6552000000000016
196317,Modify the molecule Cc1c(Br)c(C(F)(F)F)nn1[C@@H](C)C(=O)Nc1cnn(CC2CC2)c1 to increase its LogP value.,Cc1c(Br)c(C(F)(F)F)nn1[C@@H](C)C(=O)Nc1cnn(CC2CC2)c1,3.779020000000002
30454,Optimize the molecule CCOC(=O)c1sc(Sc2ccc(C(F)(F)F)cc2[N+](=O)[O-])nc1C to have a lower LogP value.,CCOC(=O)c1sc(Sc2ccc(C(F)(F)F)cc2[N+](=O)[O-])nc1C,4.706420000000002
222995,Please optimize the molecule COCC[C@]1(C(=O)[O-])CCCN(C(=O)c2ccc(=O)[nH]c2)C1 to have a higher LogP value.,COCC[C@]1(C(=O)[O-])CCCN(C(=O)c2ccc(=O)[nH]c2)C1,-0.6162999999999985
118066,Please modify the molecule COCc1nnc(NC(=O)c2ccc(N3CNc4ccccc4C3=O)cc2)s1 to increase its LogP value.,COCc1nnc(NC(=O)c2ccc(N3CNc4ccccc4C3=O)cc2)s1,2.9666000000000015
200558,Please modify the molecule Cc1c(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)sc2nc(Cc3ccccc3)[nH]c(=O)c12 to increase its LogP value.,Cc1c(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)sc2nc(Cc3ccccc3)[nH]c(=O)c12,4.374720000000003
54214,Modify the molecule CN(C)C(=O)c1cccc(NC(=O)C[NH+]2CCCC[C@@H]2C(N)=O)c1 to decrease its LogP value.,CN(C)C(=O)c1cccc(NC(=O)C[NH+]2CCCC[C@@H]2C(N)=O)c1,-0.7503999999999971
233638,Please optimize the molecule C[C@@H](c1nc([C@H]2C[NH+](C)CCN2C)no1)[C@H](O)C(F)(F)F to have a higher LogP value.,C[C@@H](c1nc([C@H]2C[NH+](C)CCN2C)no1)[C@H](O)C(F)(F)F,-0.4024999999999998
205111,Please modify the molecule Nc1ccc(SCc2ccc(Cl)cc2)nc1 to decrease its LogP value.,Nc1ccc(SCc2ccc(Cl)cc2)nc1,3.6095000000000015
105010,Optimize the molecule CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1 to have a higher LogP value.,CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1,0.7924800000000001
51745,Modify the molecule FC(F)(F)c1ccc(O[C@H]2CCN(CCn3cc[nH+]c3)C2)nc1 to decrease its LogP value.,FC(F)(F)c1ccc(O[C@H]2CCN(CCn3cc[nH+]c3)C2)nc1,1.8692999999999997
177298,Modify the molecule CSc1ccccc1[C@@H](O)[C@H](C[NH3+])c1c(F)cccc1Cl to have a lower LogP value.,CSc1ccccc1[C@@H](O)[C@H](C[NH3+])c1c(F)cccc1Cl,3.2601000000000013
166411,Optimize the molecule Cc1cc(C(=O)Nc2ccc(-n3ccnc3)c(F)c2)c2c(=O)[nH]n(C)c2n1 to have a higher LogP value.,Cc1cc(C(=O)Nc2ccc(-n3ccnc3)c(F)c2)c2c(=O)[nH]n(C)c2n1,2.14712
64401,Please modify the molecule S=C(Nc1cccc(Cl)c1Cl)N(Cc1ccc2c(c1)OCO2)Cc1ccccn1 to decrease its LogP value.,S=C(Nc1cccc(Cl)c1Cl)N(Cc1ccc2c(c1)OCO2)Cc1ccccn1,5.516300000000004
95880,Optimize the molecule C[C@@H](NC(=O)NNC(=O)C(C)(C)C)c1noc(-c2ccc(Cl)cc2)n1 to have a lower LogP value.,C[C@@H](NC(=O)NNC(=O)C(C)(C)C)c1noc(-c2ccc(Cl)cc2)n1,2.8275000000000006
177699,Modify the molecule C[C@@H]1CCN(c2ccc([N+](=O)[O-])c(S(C)(=O)=O)c2)C[C@@H]1O to decrease its LogP value.,C[C@@H]1CCN(c2ccc([N+](=O)[O-])c(S(C)(=O)=O)c2)C[C@@H]1O,1.2054
224490,Please optimize the molecule C[C@@H](C(=O)NCc1ccc(Cl)cc1)N(C)CC#N to have a lower LogP value.,C[C@@H](C(=O)NCc1ccc(Cl)cc1)N(C)CC#N,1.80008
55076,Modify the molecule NC(=O)c1cc(Cl)ccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21 to have a lower LogP value.,NC(=O)c1cc(Cl)ccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21,3.032000000000002
145635,Modify the molecule C[C@H](CCc1cccn1C)NC(=O)C(=O)Nc1ccnn1C(C)(C)C to increase its LogP value.,C[C@H](CCc1cccn1C)NC(=O)C(=O)Nc1ccnn1C(C)(C)C,2.0525999999999995
30563,Modify the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)c3cc(C)ccc3O)C2)c1 to have a higher LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)c3cc(C)ccc3O)C2)c1,2.551120000000001
183415,Modify the molecule CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1,2.4598199999999997
42202,Please modify the molecule CNC(=O)CN(C)C(=O)CCCNC(=O)c1ccco1 to decrease its LogP value.,CNC(=O)CN(C)C(=O)CCCNC(=O)c1ccco1,-0.005999999999999728
113054,Optimize the molecule CCc1nsc(SCC(=O)c2ccc(F)cc2)n1 to have a lower LogP value.,CCc1nsc(SCC(=O)c2ccc(F)cc2)n1,3.2146000000000017
169704,Please optimize the molecule COC(=O)C[C@H](NC(=O)Nc1cccnc1OC)c1cccs1 to have a higher LogP value.,COC(=O)C[C@H](NC(=O)Nc1cccnc1OC)c1cccs1,2.5776000000000003
56376,Modify the molecule C[C@@H]1C[C@@H]1C(=O)Nc1ccc2c(c1)N(C)C(=O)CO2 to have a higher LogP value.,C[C@@H]1C[C@@H]1C(=O)Nc1ccc2c(c1)N(C)C(=O)CO2,1.6362999999999999
1331,Please optimize the molecule O=Cc1ccc(-c2cc(C(F)(F)F)cc(Cl)n2)cc1 to have a higher LogP value.,O=Cc1ccc(-c2cc(C(F)(F)F)cc(Cl)n2)cc1,4.233300000000002
113821,Please modify the molecule C[C@@H](Cc1ccc(O)cc1)NC(=O)C(=O)Nc1ccc(Oc2ccccc2)cc1 to decrease its LogP value.,C[C@@H](Cc1ccc(O)cc1)NC(=O)C(=O)Nc1ccc(Oc2ccccc2)cc1,3.870400000000002
157998,Optimize the molecule CCc1ccc(CN[C@@](C)(CC(C)C)C(N)=O)cc1 to have a lower LogP value.,CCc1ccc(CN[C@@](C)(CC(C)C)C(N)=O)cc1,2.6287000000000003
132855,Optimize the molecule CC(=O)Nc1ccc(C)cc1S(=O)(=O)Nc1ccc(C2(C(=O)NC(C)C)CC2)cc1 to have a higher LogP value.,CC(=O)Nc1ccc(C)cc1S(=O)(=O)Nc1ccc(C2(C(=O)NC(C)C)CC2)cc1,3.3104200000000024
197123,Please modify the molecule O=C(/C=C/C1CC1)NCCOc1cccc2ccccc12 to increase its LogP value.,O=C(/C=C/C1CC1)NCCOc1cccc2ccccc12,3.301000000000002
154231,Optimize the molecule CC(C)NC(=O)C(=O)N/N=C/c1ccccn1 to have a higher LogP value.,CC(C)NC(=O)C(=O)N/N=C/c1ccccn1,0.05629999999999935
52989,Optimize the molecule COCCCC(=O)N1CCCC[C@H]1[C@H]1CCC[NH2+]1 to have a higher LogP value.,COCCCC(=O)N1CCCC[C@H]1[C@H]1CCC[NH2+]1,0.5199000000000013
106343,Modify the molecule CCC(CC)[NH+](C)CCS(=O)(=O)c1cccc(Br)c1 to have a lower LogP value.,CCC(CC)[NH+](C)CCS(=O)(=O)c1cccc(Br)c1,1.9261000000000004
36073,Optimize the molecule CC(C)C[NH+]1[C@H]2CCC[C@@H]1CC(NC(=S)Nc1cccc(Cl)c1)C2 to have a higher LogP value.,CC(C)C[NH+]1[C@H]2CCC[C@@H]1CC(NC(=S)Nc1cccc(Cl)c1)C2,3.250800000000001
126040,Please optimize the molecule C[C@H](O)CC(C)(C)C[NH2+][C@@H](C)CC(F)(F)F to have a lower LogP value.,C[C@H](O)CC(C)(C)C[NH2+][C@@H](C)CC(F)(F)F,1.6878
191576,Modify the molecule Cc1cccc(NCC(=O)Nc2ccc(OC[C@@H]3CCCO3)cc2)c1 to decrease its LogP value.,Cc1cccc(NCC(=O)Nc2ccc(OC[C@@H]3CCCO3)cc2)c1,3.6034200000000025
130338,Modify the molecule CSC1(CNc2ccc([N+](=O)[O-])cc2Cl)CCOCC1 to increase its LogP value.,CSC1(CNc2ccc([N+](=O)[O-])cc2Cl)CCOCC1,3.572300000000002
239747,Please modify the molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1 to increase its LogP value.,Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1,2.622420000000001
71296,Optimize the molecule C[C@H](Cc1cccs1)C(=O)Nc1cccc(C[NH+]2CCC(O)CC2)c1 to have a higher LogP value.,C[C@H](Cc1cccs1)C(=O)Nc1cccc(C[NH+]2CCC(O)CC2)c1,2.1049999999999995
39142,Please modify the molecule O=C(CSCc1ccccc1)N/N=C/c1cc(Br)cc(Br)c1O to decrease its LogP value.,O=C(CSCc1ccccc1)N/N=C/c1cc(Br)cc(Br)c1O,4.300700000000003
187157,Please modify the molecule C[NH2+][C@@H]1[C@H]([NH+](C)Cc2ccc(F)cc2)CCCC1(C)C to decrease its LogP value.,C[NH2+][C@@H]1[C@H]([NH+](C)Cc2ccc(F)cc2)CCCC1(C)C,0.9809000000000012
56090,Modify the molecule C=CCN1C(=O)NC(=N)C1(CCC)CCC to have a higher LogP value.,C=CCN1C(=O)NC(=N)C1(CCC)CCC,2.5138700000000007
35264,Please optimize the molecule Nc1cc(N2CCC[C@@H](c3n[nH]c(=O)n3-c3ccccc3)C2)ncn1 to have a higher LogP value.,Nc1cc(N2CCC[C@@H](c3n[nH]c(=O)n3-c3ccccc3)C2)ncn1,1.3168
65027,Please optimize the molecule CCCC[NH+]1CCC(NC(=O)NC[C@H]2C[C@]23CCc2ccccc23)CC1 to have a lower LogP value.,CCCC[NH+]1CCC(NC(=O)NC[C@H]2C[C@]23CCc2ccccc23)CC1,2.0371000000000015
25364,Please optimize the molecule Cc1cc2occ(CC(=O)OCC3(C)COC3)c2cc1C to have a lower LogP value.,Cc1cc2occ(CC(=O)OCC3(C)COC3)c2cc1C,3.1718400000000013
165760,Modify the molecule C[C@@H](Oc1ccccc1C#N)C(=O)Nc1ccn(Cc2ccccn2)n1 to have a lower LogP value.,C[C@@H](Oc1ccccc1C#N)C(=O)Nc1ccn(Cc2ccccn2)n1,2.6040800000000006
185120,Optimize the molecule CC[NH2+]C1CCN(c2ccc(OC)cc2OC)CC1 to have a higher LogP value.,CC[NH2+]C1CCN(c2ccc(OC)cc2OC)CC1,1.2559000000000007
2183,Modify the molecule COc1ccc(OC)c2sc(NC(=O)c3cc4c(ccc5ccccc54)oc3=O)nc12 to have a higher LogP value.,COc1ccc(OC)c2sc(NC(=O)c3cc4c(ccc5ccccc54)oc3=O)nc12,4.825400000000003
194370,Optimize the molecule N#Cc1ccc(S(=O)(=O)CCN2CCC[C@H]2c2cccs2)cc1 to have a higher LogP value.,N#Cc1ccc(S(=O)(=O)CCN2CCC[C@H]2c2cccs2)cc1,3.2305800000000024
221410,Modify the molecule COC(=O)c1cncc(N2C[C@@H](C)OC[C@H]2C)n1 to have a lower LogP value.,COC(=O)c1cncc(N2C[C@@H](C)OC[C@H]2C)n1,0.8768
187082,Please modify the molecule Cc1ccc([C@@H]2SC[C@@H]3C(=O)N(c4cnn(C)c4C)C(=S)N32)cc1 to increase its LogP value.,Cc1ccc([C@@H]2SC[C@@H]3C(=O)N(c4cnn(C)c4C)C(=S)N32)cc1,2.7846400000000013
243358,Please optimize the molecule Cc1ccc(NC(=O)COc2ccc(Br)cn2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)COc2ccc(Br)cn2)cc1,3.170020000000001
86398,Modify the molecule CC[C@H](Sc1c([O-])on[n+]1-c1ccc(OC)cc1)C(=O)Nc1ccc(C)c(C)c1 to decrease its LogP value.,CC[C@H](Sc1c([O-])on[n+]1-c1ccc(OC)cc1)C(=O)Nc1ccc(C)c(C)c1,3.159740000000002
20953,Modify the molecule Cc1[nH]ncc1S(=O)(=O)N[C@@H]1CC[NH2+]C[C@@H]1C to increase its LogP value.,Cc1[nH]ncc1S(=O)(=O)N[C@@H]1CC[NH2+]C[C@@H]1C,-1.0317799999999981
47362,Optimize the molecule CC(=O)c1csc(N(C)Cc2cccc(C)n2)n1 to have a lower LogP value.,CC(=O)c1csc(N(C)Cc2cccc(C)n2)n1,2.6855200000000004
82654,Modify the molecule C[C@@H]1CC(N(C)[C@@H](c2ccccc2)C(F)(F)F)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CC(N(C)[C@@H](c2ccccc2)C(F)(F)F)C[C@@H](C)O1,4.177800000000004
157664,Please optimize the molecule COc1ccc(CNC(=O)Cn2c(N3CCCCC3)nc3ccsc3c2=O)cc1 to have a higher LogP value.,COc1ccc(CNC(=O)Cn2c(N3CCCCC3)nc3ccsc3c2=O)cc1,2.7733000000000008
128614,Modify the molecule C[C@]1(C(=O)NC2CCCCCCC2)Oc2ccccc2NC1=O to increase its LogP value.,C[C@]1(C(=O)NC2CCCCCCC2)Oc2ccccc2NC1=O,3.005300000000001
89246,Please optimize the molecule CC(C)Cn1cc(NC(=O)c2cccnc2[S-])cn1 to have a higher LogP value.,CC(C)Cn1cc(NC(=O)c2cccnc2[S-])cn1,2.0921999999999996
244215,Please optimize the molecule CNC(=O)c1ccc([C@@H]2Nc3ccccc3C(=O)N2C[C@@H]2CCCO2)cc1 to have a lower LogP value.,CNC(=O)c1ccc([C@@H]2Nc3ccccc3C(=O)N2C[C@@H]2CCCO2)cc1,2.7917000000000014
30639,Modify the molecule C[C@H](OC(=O)c1ccccc1Oc1cccnc1)[C@@H]1CCOC1 to increase its LogP value.,C[C@H](OC(=O)c1ccccc1Oc1cccnc1)[C@@H]1CCOC1,3.455700000000002
13196,Please optimize the molecule CCN(C(=O)Cn1cc(S(=O)(=O)N2CCCCCC2)ccc1=O)c1ccccc1 to have a lower LogP value.,CCN(C(=O)Cn1cc(S(=O)(=O)N2CCCCCC2)ccc1=O)c1ccccc1,2.4661
195964,Modify the molecule Cc1ccc(Cc2nnc(NC(=O)c3ccc4c(c3)OCO4)o2)c(C)c1 to have a higher LogP value.,Cc1ccc(Cc2nnc(NC(=O)c3ccc4c(c3)OCO4)o2)c(C)c1,3.2582400000000016
58871,Please modify the molecule CCCN1CCc2nc[nH]c2C12CC[NH+](Cc1cc(OC)ccc1F)CC2 to increase its LogP value.,CCCN1CCc2nc[nH]c2C12CC[NH+](Cc1cc(OC)ccc1F)CC2,1.8997
183437,Please modify the molecule C[C@H]1CSC(SCC(=O)Nc2ccccc2[N+](=O)[O-])=N1 to decrease its LogP value.,C[C@H]1CSC(SCC(=O)Nc2ccccc2[N+](=O)[O-])=N1,2.7578000000000005
201670,Please optimize the molecule COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(C)cc2)c1NC(=O)C1CCCCC1 to have a higher LogP value.,COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(C)cc2)c1NC(=O)C1CCCCC1,4.411360000000004
243106,Please modify the molecule CCC[C@@H](NC(=O)N1CCOCC1)C(N)=[NH2+] to increase its LogP value.,CCC[C@@H](NC(=O)N1CCOCC1)C(N)=[NH2+],-1.6867999999999963
158620,Modify the molecule O[C@H]1CCC[C@H]1n1cccn1 to have a lower LogP value.,O[C@H]1CCC[C@H]1n1cccn1,0.969
100864,Modify the molecule O=C(Nc1ccccc1)NC1CC[NH+](C[C@H](O)c2ccc(F)c(F)c2)CC1 to decrease its LogP value.,O=C(Nc1ccccc1)NC1CC[NH+](C[C@H](O)c2ccc(F)c(F)c2)CC1,1.8672000000000002
22567,Modify the molecule N#Cc1ccc(COC(=O)c2nn(-c3ccccc3F)cc2Br)cc1 to increase its LogP value.,N#Cc1ccc(COC(=O)c2nn(-c3ccccc3F)cc2Br)cc1,4.002580000000002
56045,Please modify the molecule Cc1cc(N)cc(C)c1S(=O)(=O)NCC1CC1 to increase its LogP value.,Cc1cc(N)cc(C)c1S(=O)(=O)NCC1CC1,1.57394
56303,Optimize the molecule COc1ccccc1-n1nc(C(=O)N2CCCC[C@H]2C)c2ccccc2c1=O to have a higher LogP value.,COc1ccccc1-n1nc(C(=O)N2CCCC[C@H]2C)c2ccccc2c1=O,3.408900000000002
220102,Please modify the molecule CNC(=O)c1cccc(NC(=O)[C@H](C)[NH+]2CCC([C@H](O)c3ccccc3)CC2)c1 to increase its LogP value.,CNC(=O)c1cccc(NC(=O)[C@H](C)[NH+]2CCC([C@H](O)c3ccccc3)CC2)c1,1.401700000000001
4731,Modify the molecule COc1ccc(C)cc1[C@@H](C)[NH2+][C@H](C)C(=O)Nc1ccc(C)cc1F to have a lower LogP value.,COc1ccc(C)cc1[C@@H](C)[NH2+][C@H](C)C(=O)Nc1ccc(C)cc1F,3.1027400000000007
146418,Modify the molecule C[C@@H]1CCC[C@H](CC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)C1 to have a higher LogP value.,C[C@@H]1CCC[C@H](CC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)C1,3.682400000000002
810,Modify the molecule O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1,4.167800000000004
92203,Modify the molecule Cc1cc(Cl)ccc1NC(=O)C(=O)NCc1ccccc1C[NH+](C)C to decrease its LogP value.,Cc1cc(Cl)ccc1NC(=O)C(=O)NCc1ccccc1C[NH+](C)C,1.5478199999999993
206572,Optimize the molecule COC[C@@H](O)CN(C)c1ccc(C(N)=O)nn1 to have a lower LogP value.,COC[C@@H](O)CN(C)c1ccc(C(N)=O)nn1,-0.9809999999999992
248529,Modify the molecule O=C(Nc1cc([N+](=O)[O-])ccc1Cl)c1nc[nH]n1 to decrease its LogP value.,O=C(Nc1cc([N+](=O)[O-])ccc1Cl)c1nc[nH]n1,1.6185999999999996
10043,Modify the molecule O=C([C@H](O)c1ccccc1Cl)N1CCN(c2ccccc2Cl)C(=O)C1 to increase its LogP value.,O=C([C@H](O)c1ccccc1Cl)N1CCN(c2ccccc2Cl)C(=O)C1,2.9022000000000014
208585,Please optimize the molecule COc1cc([C@@H]2CN(C(=O)c3ccccc3)C[C@H]2C(=O)NC(C)C)cc(OC)c1OC to have a higher LogP value.,COc1cc([C@@H]2CN(C(=O)c3ccccc3)C[C@H]2C(=O)NC(C)C)cc(OC)c1OC,3.0928000000000013
173827,Please optimize the molecule CO[C@H](CNC(=O)NC[C@@H](O)c1ccc(F)cc1)c1cccc(Cl)c1 to have a higher LogP value.,CO[C@H](CNC(=O)NC[C@@H](O)c1ccc(F)cc1)c1cccc(Cl)c1,3.1994000000000016
149142,Please modify the molecule CCc1nc(C)c([C@@H](C)[NH2+]Cc2c(CC)nn(C)c2CC)s1 to increase its LogP value.,CCc1nc(C)c([C@@H](C)[NH2+]Cc2c(CC)nn(C)c2CC)s1,2.6968200000000007
177127,Please optimize the molecule COc1ccccc1S(=O)(=O)C[C@@H]1CCC[NH2+]1 to have a higher LogP value.,COc1ccccc1S(=O)(=O)C[C@@H]1CCC[NH2+]1,0.19470000000000043
154586,Optimize the molecule CCN1CC[NH+]([C@@H](c2ccc(Br)cc2)c2sc3nc(C)nn3c2[O-])CC1 to have a lower LogP value.,CCN1CC[NH+]([C@@H](c2ccc(Br)cc2)c2sc3nc(C)nn3c2[O-])CC1,1.2451200000000002
96301,Please modify the molecule COc1ccc(S(=O)(=O)N(C2CC2)[C@@H](C)C2CC2)cc1OC to decrease its LogP value.,COc1ccc(S(=O)(=O)N(C2CC2)[C@@H](C)C2CC2)cc1OC,2.655400000000001
68965,Modify the molecule CC(C)C(=O)N1CCC(NC(=O)C2(c3cccc(Cl)c3)CC2)CC1 to have a higher LogP value.,CC(C)C(=O)N1CCC(NC(=O)C2(c3cccc(Cl)c3)CC2)CC1,3.134800000000001
184234,Please modify the molecule CC(C)CC[C@H]1CCCN(C(=O)C(=O)Nc2ccc(C(N)=O)cc2F)C1 to increase its LogP value.,CC(C)CC[C@H]1CCCN(C(=O)C(=O)Nc2ccc(C(N)=O)cc2F)C1,2.5379000000000005
134012,Modify the molecule Cc1cc(F)ccc1[C@H](O)C1(C[NH3+])CCOCC1 to increase its LogP value.,Cc1cc(F)ccc1[C@H](O)C1(C[NH3+])CCOCC1,1.20622
109591,Please modify the molecule COc1ccccc1CNC(=O)N1CCN([C@H](C)C(=O)NC2CC2)CC1 to increase its LogP value.,COc1ccccc1CNC(=O)N1CCN([C@H](C)C(=O)NC2CC2)CC1,1.1895
52861,Please optimize the molecule CCc1ccc(C(C)(C)NC(=O)C2CCN(C(=O)c3ccoc3)CC2)cc1 to have a lower LogP value.,CCc1ccc(C(C)(C)NC(=O)C2CCN(C(=O)c3ccoc3)CC2)cc1,3.745700000000003
241240,Please optimize the molecule COc1ccc(CN(C(=O)c2nc3nccc(C)n3n2)[C@H](C)C2CC2)cc1 to have a lower LogP value.,COc1ccc(CN(C(=O)c2nc3nccc(C)n3n2)[C@H](C)C2CC2)cc1,2.882220000000001
113425,Please optimize the molecule C[C@@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1cccnc1 to have a lower LogP value.,C[C@@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1cccnc1,2.0919
110477,Optimize the molecule COC(=O)/C=C/Sc1ccc(C(F)(F)F)cc1N to have a lower LogP value.,COC(=O)/C=C/Sc1ccc(C(F)(F)F)cc1N,3.0664000000000007
19408,Please optimize the molecule Cc1ccc(N2CCC(C(=O)NCc3ccc[nH]3)CC2)[nH+]c1 to have a higher LogP value.,Cc1ccc(N2CCC(C(=O)NCc3ccc[nH]3)CC2)[nH+]c1,1.6700199999999996
82776,Optimize the molecule CN(Cc1cc(Cl)cn1C)C(=O)NCc1ccnc(OC2CCC2)c1 to have a higher LogP value.,CN(Cc1cc(Cl)cn1C)C(=O)NCc1ccnc(OC2CCC2)c1,3.346400000000002
145307,Please modify the molecule CC[C@H](NC(=O)N[C@@H]1CCCc2c1cnn2C)c1cccs1 to increase its LogP value.,CC[C@H](NC(=O)N[C@@H]1CCCc2c1cnn2C)c1cccs1,3.3095000000000017
62856,Optimize the molecule Cc1ccncc1NC(=O)N1CCC2(C1)OCCO2 to have a higher LogP value.,Cc1ccncc1NC(=O)N1CCC2(C1)OCCO2,1.3707199999999997
180601,Optimize the molecule C1CCN(c2nc(NC3CCCC3)nc3n[nH]nc23)CC1 to have a lower LogP value.,C1CCN(c2nc(NC3CCCC3)nc3n[nH]nc23)CC1,2.0927
91767,Modify the molecule COc1ccc(C(=O)N[C@H](C(=O)NCc2cccnc2)C(C)C)cc1 to have a higher LogP value.,COc1ccc(C(=O)N[C@H](C(=O)NCc2cccnc2)C(C)C)cc1,2.1609999999999996
188174,Please modify the molecule C[NH+](C)CCN(Cc1cccs1)C(=O)c1cc(Cl)c2c(c1)OCO2 to increase its LogP value.,C[NH+](C)CCN(Cc1cccs1)C(=O)c1cc(Cl)c2c(c1)OCO2,1.9171000000000002
85647,Optimize the molecule O=C([O-])c1ccc(C(F)(F)F)nc1NC[C@@H]1CCOC1 to have a lower LogP value.,O=C([O-])c1ccc(C(F)(F)F)nc1NC[C@@H]1CCOC1,0.9122999999999999
210269,Please optimize the molecule CCS(=O)(=O)N(C)C1CCN(C(=O)[C@@H]2CCO[C@@H]2C)CC1 to have a higher LogP value.,CCS(=O)(=O)N(C)C1CCN(C(=O)[C@@H]2CCO[C@@H]2C)CC1,0.6839000000000008
186479,Modify the molecule COC[C@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)C(C)C to have a higher LogP value.,COC[C@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)C(C)C,1.051800000000002
174207,Please optimize the molecule Cc1cc(NC(=O)CN2CCN(C(=O)[C@@H](C)Sc3cc(Cl)ccc3Cl)CC2)no1 to have a higher LogP value.,Cc1cc(NC(=O)CN2CCN(C(=O)[C@@H](C)Sc3cc(Cl)ccc3Cl)CC2)no1,3.553320000000002
55027,Optimize the molecule Cc1ccc(C)c(-c2cc(C(=O)[O-])c3cc(C)ccc3n2)c1 to have a lower LogP value.,Cc1ccc(C)c(-c2cc(C(=O)[O-])c3cc(C)ccc3n2)c1,3.1905600000000014
114133,Modify the molecule O=C(c1csc(-c2ccccc2)n1)N1CCC(Cn2cc[nH+]c2)CC1 to increase its LogP value.,O=C(c1csc(-c2ccccc2)n1)N1CCC(Cn2cc[nH+]c2)CC1,2.9781000000000004
176782,Modify the molecule Cc1c(O)ccc2c(C[NH+]3CCC(C)CC3)cc(=O)oc12 to have a higher LogP value.,Cc1c(O)ccc2c(C[NH+]3CCC(C)CC3)cc(=O)oc12,1.62182
187382,Modify the molecule N#Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccccn3)C2)cc1 to have a lower LogP value.,N#Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccccn3)C2)cc1,1.9404799999999998
241468,Modify the molecule CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O to have a higher LogP value.,CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O,3.120540000000002
22471,Please optimize the molecule CCOc1ccc(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1 to have a higher LogP value.,CCOc1ccc(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1,3.499200000000002
233014,Please modify the molecule C=CCN(C(=O)[C@@H]1CCCN1S(C)(=O)=O)c1nc2ccccc2s1 to increase its LogP value.,C=CCN(C(=O)[C@@H]1CCCN1S(C)(=O)=O)c1nc2ccccc2s1,2.2393
14686,Please modify the molecule COC[C@H](C)C(=O)NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1 to increase its LogP value.,COC[C@H](C)C(=O)NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1,-0.39659999999999673
4704,Please modify the molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCC[C@@H]1[C@@H]1CCCCC1=O to increase its LogP value.,CC(C)CNC(=O)[C@H](C)[NH+]1CCC[C@@H]1[C@@H]1CCCCC1=O,0.9537000000000011
63212,Optimize the molecule CC(C)[C@@H](CO)NC(=O)NCCNC(=O)c1ccc(F)cc1 to have a higher LogP value.,CC(C)[C@@H](CO)NC(=O)NCCNC(=O)c1ccc(F)cc1,0.8716
172690,Modify the molecule O=C([O-])CNC(=O)/C=C/c1c(Cl)cccc1Cl to have a higher LogP value.,O=C([O-])CNC(=O)/C=C/c1c(Cl)cccc1Cl,0.8727
143010,Modify the molecule C[C@@H]1CSC(=O)N1CCC(=O)OCC1=NC(=O)[C@H]2SC=CC2=N1 to have a lower LogP value.,C[C@@H]1CSC(=O)N1CCC(=O)OCC1=NC(=O)[C@H]2SC=CC2=N1,1.4858
44259,Optimize the molecule CCc1cccc(C)c1NC(=O)[C@H](CC)n1nc(C)c2sc3ccccc3c2c1=O to have a higher LogP value.,CCc1cccc(C)c1NC(=O)[C@H](CC)n1nc(C)c2sc3ccccc3c2c1=O,5.380240000000005
236427,Please optimize the molecule Cc1cccc(C(C)(C)NC(=O)CCSc2nc(C)n[nH]2)c1 to have a lower LogP value.,Cc1cccc(C(C)(C)NC(=O)CCSc2nc(C)n[nH]2)c1,2.9552400000000008
150457,Please optimize the molecule NC(=O)c1ccc(Oc2nccnc2[C@H]2CCCN(Cc3ccccn3)C2)cc1 to have a higher LogP value.,NC(=O)c1ccc(Oc2nccnc2[C@H]2CCCN(Cc3ccccn3)C2)cc1,3.142400000000002
237469,Please optimize the molecule Cc1n[nH]c2cc(NC(=O)CCN3C(=O)COc4ccccc43)ccc12 to have a higher LogP value.,Cc1n[nH]c2cc(NC(=O)CCN3C(=O)COc4ccccc43)ccc12,2.6255200000000007
195478,Modify the molecule C[C@H]1C[NH2+]CCN1C1CCCCC1 to decrease its LogP value.,C[C@H]1C[NH2+]CCN1C1CCCCC1,0.5866000000000002
168319,Modify the molecule O=C(Nc1cccc(C[NH+]2CCCC2)c1)c1n[nH]c2ccccc12 to increase its LogP value.,O=C(Nc1cccc(C[NH+]2CCCC2)c1)c1n[nH]c2ccccc12,1.9938999999999991
22235,Modify the molecule O=C1S/C(=C\c2ccc3c(c2)OCO3)C(=O)N1CNc1cccc(Cl)c1 to have a higher LogP value.,O=C1S/C(=C\c2ccc3c(c2)OCO3)C(=O)N1CNc1cccc(Cl)c1,4.174600000000002
52258,Modify the molecule C[C@@H](NC(=O)c1csnn1)c1ccc(OCc2cccnc2)cc1 to have a lower LogP value.,C[C@@H](NC(=O)c1csnn1)c1ccc(OCc2cccnc2)cc1,3.0031000000000017
68248,Please optimize the molecule CCCc1cc(NCCn2cccn2)n2ncnc2n1 to have a lower LogP value.,CCCc1cc(NCCn2cccn2)n2ncnc2n1,1.3853999999999997
63944,Modify the molecule Cc1cc(C)cc(CS(=O)(=O)Cc2ccc(F)cc2)c1 to have a higher LogP value.,Cc1cc(C)cc(CS(=O)(=O)Cc2ccc(F)cc2)c1,3.557540000000002
246660,Optimize the molecule COC(=O)Cn1cc(/C=C2/C(=O)NC(=O)N(c3ccccc3)C2=O)c2ccccc21 to have a higher LogP value.,COC(=O)Cn1cc(/C=C2/C(=O)NC(=O)N(c3ccccc3)C2=O)c2ccccc21,2.4807000000000006
77515,Modify the molecule C[C@@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)Oc1cccc(Cl)c1)C2=O to have a lower LogP value.,C[C@@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)Oc1cccc(Cl)c1)C2=O,3.382200000000002
142650,Modify the molecule CCc1ccc([C@@H](C)NC(=O)Nc2cccc(OC[C@H]3CCCO3)c2)cc1 to have a higher LogP value.,CCc1ccc([C@@H](C)NC(=O)Nc2cccc(OC[C@H]3CCCO3)c2)cc1,4.689500000000003
161674,Modify the molecule Cc1ccc(NC(=O)[C@H]2CCCN(c3ccc(-n4ccnc4)nn3)C2)cc1 to have a higher LogP value.,Cc1ccc(NC(=O)[C@H]2CCCN(c3ccc(-n4ccnc4)nn3)C2)cc1,2.825820000000001
47294,Please modify the molecule Cc1ccccc1NC(=O)c1c(F)c(F)cc(F)c1F to decrease its LogP value.,Cc1ccccc1NC(=O)c1c(F)c(F)cc(F)c1F,3.803720000000001
28997,Please optimize the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(N)cc1 to have a lower LogP value.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(N)cc1,0.5246000000000005
188273,Modify the molecule Cc1ccc(Cl)c2sc(N(CCCN3CCOCC3)C(=O)c3cnccn3)nc12 to have a higher LogP value.,Cc1ccc(Cl)c2sc(N(CCCN3CCOCC3)C(=O)c3cnccn3)nc12,3.4172200000000013
245321,Optimize the molecule CC(C)(O)CCOc1ccc2c(c1)OC(C)(C)C[C@H]2[NH3+] to have a higher LogP value.,CC(C)(O)CCOc1ccc2c(c1)OC(C)(C)C[C@H]2[NH3+],2.0705
48072,Optimize the molecule CO[C@H](CNCc1cc2ccccc2[nH]c1=O)c1ccccc1 to have a lower LogP value.,CO[C@H](CNCc1cc2ccccc2[nH]c1=O)c1ccccc1,3.0054000000000007
92820,Please modify the molecule CC(=O)Nc1ccc(C)cc1S(=O)(=O)N1CCC(c2nnc(C(=O)Nc3ccccc3)s2)CC1 to increase its LogP value.,CC(=O)Nc1ccc(C)cc1S(=O)(=O)N1CCC(c2nnc(C(=O)Nc3ccccc3)s2)CC1,3.6255200000000025
234590,Modify the molecule CC(C)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccccc1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccccc1,3.1884000000000015
136003,Modify the molecule C[C@H](Nc1ccccc1OC(F)(F)F)C1CC[NH+](C)CC1 to increase its LogP value.,C[C@H](Nc1ccccc1OC(F)(F)F)C1CC[NH+](C)CC1,2.3103
51847,Optimize the molecule CC(=O)c1cccc(S(=O)(=O)Nc2ccc3c(c2)N(C(=O)C(C)(C)C)CC3)c1 to have a lower LogP value.,CC(=O)c1cccc(S(=O)(=O)Nc2ccc3c(c2)N(C(=O)C(C)(C)C)CC3)c1,3.625200000000002
53125,Please modify the molecule CCOc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c([N+](=O)[O-])c1 to decrease its LogP value.,CCOc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c([N+](=O)[O-])c1,3.553600000000002
116141,Please optimize the molecule Cc1cc(C(=O)N2CCN(C(=O)CCc3c(C)n[nH]c3C)CC2)c(C)o1 to have a lower LogP value.,Cc1cc(C(=O)N2CCN(C(=O)CCc3c(C)n[nH]c3C)CC2)c(C)o1,2.15358
140770,Modify the molecule Cc1ccc(C(=O)NCC(=O)N2CC=C(c3ccccc3)CC2)s1 to have a higher LogP value.,Cc1ccc(C(=O)NCC(=O)N2CC=C(c3ccccc3)CC2)s1,3.1022200000000018
1592,Modify the molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O to decrease its LogP value.,COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O,2.6839000000000017
242076,Please modify the molecule CCn1nccc1[C@@H](C)[NH2+]Cc1cc(-c2cccs2)n[nH]1 to decrease its LogP value.,CCn1nccc1[C@@H](C)[NH2+]Cc1cc(-c2cccs2)n[nH]1,2.1792000000000002
54498,Please optimize the molecule O=C(Nc1ccccc1Cl)c1ccc(-n2cccn2)nn1 to have a lower LogP value.,O=C(Nc1ccccc1Cl)c1ccc(-n2cccn2)nn1,2.5680000000000005
245263,Optimize the molecule COc1cc(C2(C(=O)Nc3ccc(C(=O)N(C)C)c(C)c3)CC2)ccc1C to have a higher LogP value.,COc1cc(C2(C(=O)Nc3ccc(C(=O)N(C)C)c(C)c3)CC2)ccc1C,3.684140000000003
65302,Please optimize the molecule C[C@@H]1CC[C@H]([NH3+])[C@H](C(=O)NC[C@@H]2CN3CCC[C@@H]3CO2)C1 to have a higher LogP value.,C[C@@H]1CC[C@H]([NH3+])[C@H](C(=O)NC[C@@H]2CN3CCC[C@@H]3CO2)C1,0.012500000000001954
146098,Modify the molecule C/[NH+]=C(/NC[C@@H]1CCO[C@@H]1c1ccccc1)N1CC[C@H](c2ccccc2)C1 to increase its LogP value.,C/[NH+]=C(/NC[C@@H]1CCO[C@@H]1c1ccccc1)N1CC[C@H](c2ccccc2)C1,1.9097000000000004
3913,Optimize the molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 to have a lower LogP value.,COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1,3.4636000000000022
117737,Modify the molecule [NH3+]C[C@@H]1CC[C@H](C(=O)OCc2ccccc2Cl)O1 to increase its LogP value.,[NH3+]C[C@@H]1CC[C@H](C(=O)OCc2ccccc2Cl)O1,1.1727000000000005
184305,Please modify the molecule COC(=O)[C@]1(C)CCN(C(=O)Nc2cnc(-c3ccccc3)s2)C1 to decrease its LogP value.,COC(=O)[C@]1(C)CCN(C(=O)Nc2cnc(-c3ccccc3)s2)C1,3.227000000000001
63537,Modify the molecule O=C(Cc1ccc(F)cc1)O[C@@H](c1ccccc1)c1ccccn1 to increase its LogP value.,O=C(Cc1ccc(F)cc1)O[C@@H](c1ccccc1)c1ccccn1,4.096000000000003
72396,Please modify the molecule Cc1cc(CN2C(=O)[C@H]3CCCN3C(=O)[C@@H]2C)on1 to increase its LogP value.,Cc1cc(CN2C(=O)[C@H]3CCCN3C(=O)[C@@H]2C)on1,0.70472
248027,Modify the molecule C[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)oc(=O)n2C to have a higher LogP value.,C[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)oc(=O)n2C,2.675300000000001
181835,Optimize the molecule COc1ccc(S(=O)(=O)[N-]c2ccc(F)cc2C)c([N+](=O)[O-])c1 to have a higher LogP value.,COc1ccc(S(=O)(=O)[N-]c2ccc(F)cc2C)c([N+](=O)[O-])c1,3.445020000000002
153733,Please optimize the molecule Cc1ccc(F)cc1NS(=O)(=O)c1ccc2c(c1)CCCC2 to have a lower LogP value.,Cc1ccc(F)cc1NS(=O)(=O)c1ccc2c(c1)CCCC2,3.8137200000000027
9065,Optimize the molecule Cc1n[nH]c([C@H]2CN(CCCn3c(=O)oc4ccccc43)CCO2)n1 to have a lower LogP value.,Cc1n[nH]c([C@H]2CN(CCCn3c(=O)oc4ccccc43)CCO2)n1,1.4846199999999998
71054,Please modify the molecule Cc1cccc(C2=CCN(C(=O)/C=C/c3ccc(C(N)=O)cc3)CC2)c1 to increase its LogP value.,Cc1cccc(C2=CCN(C(=O)/C=C/c3ccc(C(N)=O)cc3)CC2)c1,3.423020000000001
186272,Please modify the molecule COc1ccccc1N1CCN(CC(=O)Nc2sc3c(c2C(N)=O)CCC3)CC1 to decrease its LogP value.,COc1ccccc1N1CCN(CC(=O)Nc2sc3c(c2C(N)=O)CCC3)CC1,2.1049999999999995
6192,Please modify the molecule CCS(=O)(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1 to increase its LogP value.,CCS(=O)(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1,1.0726999999999998
215162,Please optimize the molecule Cn1nc(NC(=O)c2ccccc2)c2c1NC(=O)C[C@H]2c1ccco1 to have a higher LogP value.,Cn1nc(NC(=O)c2ccccc2)c2c1NC(=O)C[C@H]2c1ccco1,2.7395000000000005
141498,Optimize the molecule O=C(N[C@H]1CC=NN1C1CC[NH+](C[C@@H]2C=CN=N2)CC1)c1ccccc1 to have a higher LogP value.,O=C(N[C@H]1CC=NN1C1CC[NH+](C[C@@H]2C=CN=N2)CC1)c1ccccc1,0.829400000000001
99573,Please modify the molecule COc1cc(C[NH2+][C@@H]2CCC[C@H](C)C2)ccc1OCc1ccncc1 to increase its LogP value.,COc1cc(C[NH2+][C@@H]2CCC[C@H](C)C2)ccc1OCc1ccncc1,3.311300000000002
2546,Modify the molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC to increase its LogP value.,COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC,0.7697000000000009
161922,Please optimize the molecule COc1cc(C[NH+](C)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2=O)ccc1O to have a higher LogP value.,COc1cc(C[NH+](C)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2=O)ccc1O,0.8866999999999996
207495,Optimize the molecule C[C@H]1CC[NH+](CCC(=O)NCc2ccccc2Cl)C[C@@H]1O to have a lower LogP value.,C[C@H]1CC[NH+](CCC(=O)NCc2ccccc2Cl)C[C@@H]1O,0.6319000000000001
160344,Optimize the molecule Cc1csc(NC(=O)N2CCC[C@H](c3nc4ccccc4o3)C2)n1 to have a higher LogP value.,Cc1csc(NC(=O)N2CCC[C@H](c3nc4ccccc4o3)C2)n1,4.004220000000003
2142,Please modify the molecule Cc1ccc([C@@]23CCC(=O)N2CCC[NH2+]3)cc1 to increase its LogP value.,Cc1ccc([C@@]23CCC(=O)N2CCC[NH2+]3)cc1,0.7373199999999999
191746,Please optimize the molecule COC(=O)c1ccc(/C=c2\s/c(=C(/C#N)C(=O)NC3CC3)n(-c3ccccc3)c2=O)cc1 to have a higher LogP value.,COC(=O)c1ccc(/C=c2\s/c(=C(/C#N)C(=O)NC3CC3)n(-c3ccccc3)c2=O)cc1,1.4672799999999997
129283,Please modify the molecule O=C(NCCS(=O)(=O)c1ccccc1)N[C@H]1CC=CCC1 to increase its LogP value.,O=C(NCCS(=O)(=O)c1ccccc1)N[C@H]1CC=CCC1,1.8682
92848,Please optimize the molecule CC(C)[C@@H]([NH2+]Cc1cccnc1)c1ccc2c(c1)CCO2 to have a higher LogP value.,CC(C)[C@@H]([NH2+]Cc1cccnc1)c1ccc2c(c1)CCO2,2.4772
241986,Modify the molecule COc1cccc(F)c1[C@H](C)NC(=O)N(CCO)Cc1ccccc1 to have a lower LogP value.,COc1cccc(F)c1[C@H](C)NC(=O)N(CCO)Cc1ccccc1,3.099400000000002
79178,Modify the molecule Cc1ccc(C#N)c(Nn2c(C)ccc2C)n1 to have a higher LogP value.,Cc1ccc(C#N)c(Nn2c(C)ccc2C)n1,2.5552400000000004
188312,Optimize the molecule CC(C)[C@H](C)[NH2+]CC1CCS(=O)(=O)CC1 to have a higher LogP value.,CC(C)[C@H](C)[NH2+]CC1CCS(=O)(=O)CC1,0.4191000000000009
187906,Please modify the molecule CC(=O)c1cccc(S(=O)(=O)N(C)CC(N)=O)c1 to decrease its LogP value.,CC(=O)c1cccc(S(=O)(=O)N(C)CC(N)=O)c1,-0.0050000000000000044
123691,Please modify the molecule C[C@H]1C[C@@H](C)CN(C(=O)c2ccccc2NC(=O)[C@@H](C)c2ccc3c(c2)OCCO3)C1 to decrease its LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)c2ccccc2NC(=O)[C@@H](C)c2ccc3c(c2)OCCO3)C1,4.318100000000004
65143,Modify the molecule CCCCC(=O)NC(=S)Nc1ccc(C)c(C)c1 to have a lower LogP value.,CCCCC(=O)NC(=S)Nc1ccc(C)c(C)c1,3.3066400000000016
173429,Please modify the molecule O=C(Nc1cc2c3c(c1)CC(=O)N3CCC2)c1ccc(F)c(F)c1 to increase its LogP value.,O=C(Nc1cc2c3c(c1)CC(=O)N3CCC2)c1ccc(F)c(F)c1,3.0524000000000013
176051,Modify the molecule CCCC(=O)N(CCN1CCOCC1)c1nc2c(C)ccc(C)c2s1 to have a lower LogP value.,CCCC(=O)N(CCN1CCOCC1)c1nc2c(C)ccc(C)c2s1,3.378440000000002
55973,Please modify the molecule C[C@H]1CN(CCC(=O)[O-])S(=O)(=O)C1 to decrease its LogP value.,C[C@H]1CN(CCC(=O)[O-])S(=O)(=O)C1,-1.5920999999999985
105877,Modify the molecule C[C@@H](N[C@@H](CCC#N)c1ccccc1)c1ccc(F)c(Cl)c1 to have a lower LogP value.,C[C@@H](N[C@@H](CCC#N)c1ccccc1)c1ccc(F)c(Cl)c1,5.174780000000004
13117,Modify the molecule O=C([O-])/C(=C/c1ccsc1)c1ccccc1 to have a lower LogP value.,O=C([O-])/C(=C/c1ccsc1)c1ccccc1,2.0385999999999997
245303,Please modify the molecule Cc1ccccc1C(=O)NNc1ncnc(N(C)C)c1N to decrease its LogP value.,Cc1ccccc1C(=O)NNc1ncnc(N(C)C)c1N,1.19012
248909,Optimize the molecule O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)C1(n2cnnn2)CCCCC1 to have a higher LogP value.,O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)C1(n2cnnn2)CCCCC1,3.266300000000002
25044,Please optimize the molecule CCOC(=O)C1CCC([NH+](C)C2CCS(=O)(=O)CC2)CC1 to have a higher LogP value.,CCOC(=O)C1CCC([NH+](C)C2CCS(=O)(=O)CC2)CC1,0.20020000000000215
144916,Optimize the molecule Cc1csc(S(=O)(=O)CC(=O)N[C@H]2CCCC[C@H]2C)n1 to have a higher LogP value.,Cc1csc(S(=O)(=O)CC(=O)N[C@H]2CCCC[C@H]2C)n1,1.92012
45462,Please optimize the molecule Cc1[nH]ncc1C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1 to have a higher LogP value.,Cc1[nH]ncc1C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1,0.8679199999999991
172500,Please modify the molecule CC(=O)N1CCC(NC(=O)c2c(C)nn(C)c2Cl)CC1 to increase its LogP value.,CC(=O)N1CCC(NC(=O)c2c(C)nn(C)c2Cl)CC1,1.12262
109051,Modify the molecule C[C@@H](O)C[C@H]1CCC[NH+]1CCC(=O)N(C)CCC#N to have a lower LogP value.,C[C@@H](O)C[C@H]1CCC[NH+]1CCC(=O)N(C)CCC#N,-0.4332199999999984
23556,Modify the molecule COc1ccc([C@@H]2C[C@@H]3C(=O)N=N[C@@H](SCC(=O)Nc4ccc(C)cc4Cl)N3N2)cc1OC to have a lower LogP value.,COc1ccc([C@@H]2C[C@@H]3C(=O)N=N[C@@H](SCC(=O)Nc4ccc(C)cc4Cl)N3N2)cc1OC,3.9335200000000023
11764,Modify the molecule O=c1[nH]c([O-])nc(/C=C\C2=c3ccccc3=[NH+]C2)c1[N+](=O)[O-] to decrease its LogP value.,O=c1[nH]c([O-])nc(/C=C\C2=c3ccccc3=[NH+]C2)c1[N+](=O)[O-],-2.670399999999998
140187,Modify the molecule CC[C@@H](C)[NH2+][C@H]1CSCC(C)(C)C1 to have a higher LogP value.,CC[C@@H](C)[NH2+][C@H]1CSCC(C)(C)C1,1.8800000000000001
135050,Please modify the molecule C[C@@]1(C(=O)NCCn2cc[nH+]c2)Sc2ccccc2NC1=O to increase its LogP value.,C[C@@]1(C(=O)NCCn2cc[nH+]c2)Sc2ccccc2NC1=O,0.9214999999999993
69738,Modify the molecule CN(Cc1ccccc1)C(=O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1 to increase its LogP value.,CN(Cc1ccccc1)C(=O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1,1.5317
1275,Modify the molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F to increase its LogP value.,O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F,3.2348000000000017
114575,Please optimize the molecule COc1ccc(NC(=O)c2ccc(C#N)cc2F)c(OC)c1 to have a higher LogP value.,COc1ccc(NC(=O)c2ccc(C#N)cc2F)c(OC)c1,2.9668800000000015
170019,Optimize the molecule Cc1ccccc1C(=O)N1CCC2(CC1)NC(=O)c1cccc(C)c1N2 to have a lower LogP value.,Cc1ccccc1C(=O)N1CCC2(CC1)NC(=O)c1cccc(C)c1N2,3.091240000000001
157672,Modify the molecule CCC(=O)Nc1nc2ccc(NC(=O)N[C@@H](C)CC)cc2s1 to have a lower LogP value.,CCC(=O)Nc1nc2ccc(NC(=O)N[C@@H](C)CC)cc2s1,3.5648000000000017
117322,Please optimize the molecule Cc1nc2ccn(Cc3cccnc3)c(=O)c2cc1C(=O)Nc1cccc(F)c1 to have a lower LogP value.,Cc1nc2ccn(Cc3cccnc3)c(=O)c2cc1C(=O)Nc1cccc(F)c1,3.539620000000002
103608,Modify the molecule Cc1cc(C)c(C#N)c(Nc2cccnc2C)n1 to have a lower LogP value.,Cc1cc(C)c(C#N)c(Nc2cccnc2C)n1,3.0171400000000004
183807,Modify the molecule C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1 to decrease its LogP value.,C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1,-0.19639999999999858
191395,Please optimize the molecule CC(C)(C)OC(=O)c1c(F)ccc(C(=O)[O-])c1N to have a higher LogP value.,CC(C)(C)OC(=O)c1c(F)ccc(C(=O)[O-])c1N,0.7267000000000001
44617,Optimize the molecule COc1ccc2c(c1)CCN(C(=O)[C@@H]1CCCN(C(=O)NCc3cccs3)C1)C2 to have a higher LogP value.,COc1ccc2c(c1)CCN(C(=O)[C@@H]1CCCN(C(=O)NCc3cccs3)C1)C2,3.263200000000002
172635,Modify the molecule CC(=O)O[C@@H](C)C(=O)N1CCN(c2nccc(-c3ccc(C(C)(C)C)cc3)n2)CC1 to have a lower LogP value.,CC(=O)O[C@@H](C)C(=O)N1CCN(c2nccc(-c3ccc(C(C)(C)C)cc3)n2)CC1,3.0413000000000014
70241,Optimize the molecule C[C@H]1CC[C@@]([NH3+])(Cc2nccs2)[C@H](C)C1 to have a higher LogP value.,C[C@H]1CC[C@@]([NH3+])(Cc2nccs2)[C@H](C)C1,2.1224
124376,Please modify the molecule NC(=O)c1c(Cl)cccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21 to decrease its LogP value.,NC(=O)c1c(Cl)cccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21,3.032000000000002
39006,Please modify the molecule O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1 to decrease its LogP value.,O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1,0.6156999999999999
198647,Please modify the molecule COc1ccc(C2(C(=O)Nc3ccc(C(=O)N4CCCC4)cc3)CCOCC2)cc1 to increase its LogP value.,COc1ccc(C2(C(=O)Nc3ccc(C(=O)N4CCCC4)cc3)CCOCC2)cc1,3.6181000000000028
75482,Modify the molecule C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1 to have a lower LogP value.,C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1,2.4060999999999995
212624,Please modify the molecule O=S(=O)(CC1CCC1)[N-]c1cccc(-c2cn[nH]c2)c1 to increase its LogP value.,O=S(=O)(CC1CCC1)[N-]c1cccc(-c2cn[nH]c2)c1,3.211800000000002
83178,Modify the molecule O=C(NCc1ccc(O)cc1)N1CCOC[C@@H]1C1CC1 to have a lower LogP value.,O=C(NCc1ccc(O)cc1)N1CCOC[C@@H]1C1CC1,1.7126000000000003
3685,Optimize the molecule CC[C@@H](O)[C@@]1(C[NH3+])CCC[C@H](C)C1 to have a lower LogP value.,CC[C@@H](O)[C@@]1(C[NH3+])CCC[C@H](C)C1,1.1956999999999993
19420,Modify the molecule O=C(Cn1cccc1-c1nc(-c2ccc(F)c(Br)c2)no1)NCc1ccccc1F to decrease its LogP value.,O=C(Cn1cccc1-c1nc(-c2ccc(F)c(Br)c2)no1)NCc1ccccc1F,4.5622000000000025
158606,Modify the molecule Cc1cc(NC(=O)[C@@H]2Cc3ccccc3O2)no1 to have a higher LogP value.,Cc1cc(NC(=O)[C@@H]2Cc3ccccc3O2)no1,1.9252199999999997
127487,Modify the molecule CCC[NH2+][C@H](c1cccc(C)c1)[C@H]1C[NH+]2CCN1CC2 to have a higher LogP value.,CCC[NH2+][C@H](c1cccc(C)c1)[C@H]1C[NH+]2CCN1CC2,-0.40777999999999714
37648,Please modify the molecule CCN(CC(=O)NC)c1cncc(C(=O)OC)n1 to decrease its LogP value.,CCN(CC(=O)NC)c1cncc(C(=O)OC)n1,-0.16449999999999987
13656,Please modify the molecule CCn1ncc(Br)c1C(=O)NCC(=O)C(C)(C)C to decrease its LogP value.,CCn1ncc(Br)c1C(=O)NCC(=O)C(C)(C)C,2.0105000000000004
10441,Please optimize the molecule O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccncc1 to have a lower LogP value.,O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccncc1,2.0016999999999996
175401,Please modify the molecule Cc1ccc(-n2nnnc2SCC(=O)Nc2ccnn2C2CCCC2)cc1C to increase its LogP value.,Cc1ccc(-n2nnnc2SCC(=O)Nc2ccnn2C2CCCC2)cc1C,3.3215400000000015
163303,Please modify the molecule CC(=O)N[C@@H]1[C@@H](Oc2cccc([N+](=O)[O-])c2)O[C@@H]2COC(C)(C)O[C@@H]2[C@@H]1O to decrease its LogP value.,CC(=O)N[C@@H]1[C@@H](Oc2cccc([N+](=O)[O-])c2)O[C@@H]2COC(C)(C)O[C@@H]2[C@@H]1O,0.7155999999999993
207089,Please modify the molecule CC(C)C[C@@H](C)[NH2+]Cc1ccc(F)c(Br)c1 to decrease its LogP value.,CC(C)C[C@@H](C)[NH2+]Cc1ccc(F)c(Br)c1,3.0862000000000007
229630,Please optimize the molecule C[C@H](Nc1ccc(CC#N)cc1)c1ccoc1 to have a lower LogP value.,C[C@H](Nc1ccc(CC#N)cc1)c1ccoc1,3.5187800000000022
221940,Modify the molecule COC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(-c2ccccc2)cc1 to decrease its LogP value.,COC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(-c2ccccc2)cc1,3.1545000000000014
38729,Modify the molecule CN1/C(=C\C=C2\C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)C(C)(C)c2ccccc21 to increase its LogP value.,CN1/C(=C\C=C2\C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)C(C)(C)c2ccccc21,4.022370000000002
82460,Please optimize the molecule Cc1noc(C)c1C[NH+](C)C[C@@H]1CC(C2CCCCC2)=NO1 to have a higher LogP value.,Cc1noc(C)c1C[NH+](C)C[C@@H]1CC(C2CCCCC2)=NO1,2.0313399999999997
119623,Optimize the molecule COc1ccc(-c2noc(CCC(=O)Nc3ccccn3)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2noc(CCC(=O)Nc3ccccn3)n2)cc1OC,2.7201000000000004
46624,Modify the molecule Cn1cc(C[C@H]([NH3+])[C@H]2CSCCS2)cn1 to decrease its LogP value.,Cn1cc(C[C@H]([NH3+])[C@H]2CSCCS2)cn1,0.4217000000000002
235417,Optimize the molecule CCc1csc([C@@H]2CCCN(C(=O)[C@@H]3CCO[C@@H]3C)C2)n1 to have a lower LogP value.,CCc1csc([C@@H]2CCCN(C(=O)[C@@H]3CCO[C@@H]3C)C2)n1,2.836500000000001
218805,Please optimize the molecule CCc1ccc([C@@H](C)C(=O)N[C@H](CO)c2ccco2)cc1 to have a lower LogP value.,CCc1ccc([C@@H](C)C(=O)N[C@H](CO)c2ccco2)cc1,2.795300000000001
219049,Please modify the molecule Cc1ccc(C2=NO[C@@H]3[C@H]4C[C@@H]([C@H]23)[C@H]2C(=O)N(c3ccccc3)C(=O)[C@H]42)cc1 to increase its LogP value.,Cc1ccc(C2=NO[C@@H]3[C@H]4C[C@@H]([C@H]23)[C@H]2C(=O)N(c3ccccc3)C(=O)[C@H]42)cc1,3.169620000000002
164768,Optimize the molecule C[C@H]([NH2+]C[C@H](O)c1ccccc1)[C@@H](C)O to have a lower LogP value.,C[C@H]([NH2+]C[C@H](O)c1ccccc1)[C@@H](C)O,0.0526999999999998
145985,Modify the molecule C[C@H](C(=O)NC1CC1)N1CCN(C(=O)NCc2cscn2)CC1 to increase its LogP value.,C[C@H](C(=O)NC1CC1)N1CCN(C(=O)NCc2cscn2)CC1,0.6374
103373,Optimize the molecule CO[C@H]1CCCC[C@@H]1[NH2+]C1COC1 to have a higher LogP value.,CO[C@H]1CCCC[C@@H]1[NH2+]C1COC1,-0.09379999999999922
142114,Optimize the molecule O=[N+]([O-])c1ccc(N2CC[NH+](Cc3nc(COc4ccc(F)cc4)no3)CC2)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc(N2CC[NH+](Cc3nc(COc4ccc(F)cc4)no3)CC2)cc1,1.600999999999999
107014,Please modify the molecule CC[C@H]([NH2+]Cc1ccccn1)c1cc(C)ccc1OC to decrease its LogP value.,CC[C@H]([NH2+]Cc1ccccn1)c1cc(C)ccc1OC,2.6133200000000008
229526,Modify the molecule COc1cccc([C@@H](c2c(C)nn(-c3ccccc3)c2O)c2c(C)[nH]n(-c3ccccc3)c2=O)c1 to have a lower LogP value.,COc1cccc([C@@H](c2c(C)nn(-c3ccccc3)c2O)c2c(C)[nH]n(-c3ccccc3)c2=O)c1,4.8625400000000045
8247,Please optimize the molecule CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C to have a higher LogP value.,CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C,0.14740000000000086
241057,Modify the molecule Cc1nc(C2=C(N)N(C(C)C)CC2=O)sc1C to have a lower LogP value.,Cc1nc(C2=C(N)N(C(C)C)CC2=O)sc1C,1.6803400000000002
54303,Please optimize the molecule Cc1cc(C)cc(NC(=S)NC(=O)CC2CCCC2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=S)NC(=O)CC2CCCC2)c1,3.696740000000002
762,Modify the molecule CC1(C)[C@H]2OCC[C@@H]2[C@H]1NC(=O)CCNC(=O)C12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,CC1(C)[C@H]2OCC[C@@H]2[C@H]1NC(=O)CCNC(=O)C12CC3CC(CC(C3)C1)C2,2.6388000000000007
52511,Modify the molecule Cc1cc(=O)oc2cc(OCC(=O)Nc3ccc(OC(F)F)cc3)ccc12 to have a higher LogP value.,Cc1cc(=O)oc2cc(OCC(=O)Nc3ccc(OC(F)F)cc3)ccc12,3.720320000000002
220157,Please modify the molecule Cc1nc(C)n(-c2ccc(C(=O)N3C[C@H]4[C@@H](C3)C4(C)C)cc2)n1 to decrease its LogP value.,Cc1nc(C)n(-c2ccc(C(=O)N3C[C@H]4[C@@H](C3)C4(C)C)cc2)n1,2.612140000000001
110358,Please modify the molecule O=C([O-])CN1C(=O)c2ccccc2[C@@H]1O to increase its LogP value.,O=C([O-])CN1C(=O)c2ccccc2[C@@H]1O,-1.1168000000000007
125733,Please optimize the molecule COc1cccc(C(=O)Nc2nc(C(C)=O)cs2)c1F to have a lower LogP value.,COc1cccc(C(=O)Nc2nc(C(C)=O)cs2)c1F,2.7457000000000003
216801,Optimize the molecule Clc1cc(CN2CCc3cncnc3C2)cc2c1OCCO2 to have a lower LogP value.,Clc1cc(CN2CCc3cncnc3C2)cc2c1OCCO2,2.4595000000000002
134608,Modify the molecule O=C([O-])[C@@H]1CCC(=O)N(CCCOC2CCCCC2)[C@H]1c1ccco1 to increase its LogP value.,O=C([O-])[C@@H]1CCC(=O)N(CCCOC2CCCCC2)[C@H]1c1ccco1,2.048599999999999
87341,Optimize the molecule Cc1cccc(O[C@@H](C)C(=O)NNC(=O)c2cccs2)c1C to have a lower LogP value.,Cc1cccc(O[C@@H](C)C(=O)NNC(=O)c2cccs2)c1C,2.593440000000001
175644,Please optimize the molecule O=C(CN1CCN(c2ccc(F)cc2)C1=O)Nc1ccc(Cl)cc1Cl to have a lower LogP value.,O=C(CN1CCN(c2ccc(F)cc2)C1=O)Nc1ccc(Cl)cc1Cl,4.013200000000003
218410,Modify the molecule Cc1cccc(N)c1-c1nc2cccc(C)c2o1 to increase its LogP value.,Cc1cccc(N)c1-c1nc2cccc(C)c2o1,3.6938400000000025
32467,Optimize the molecule COCCNC(=O)[C@]1(C[C@@H]2CC(c3ccc(F)cc3)=NO2)CCC[NH2+]C1 to have a higher LogP value.,COCCNC(=O)[C@]1(C[C@@H]2CC(c3ccc(F)cc3)=NO2)CCC[NH2+]C1,0.815000000000001
4878,Optimize the molecule COc1ccc2c(c1)CCC/C2=N\OCC(=O)NCc1ccco1 to have a lower LogP value.,COc1ccc2c(c1)CCC/C2=N\OCC(=O)NCc1ccco1,2.661600000000001
124186,Modify the molecule CCc1nnc(-c2cccn2CC(=O)NCc2ccc(C)cc2)o1 to have a lower LogP value.,CCc1nnc(-c2cccn2CC(=O)NCc2ccc(C)cc2)o1,2.725320000000001
157886,Please optimize the molecule O=C(OCCN1CCCC1=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1 to have a lower LogP value.,O=C(OCCN1CCCC1=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1,1.8434999999999993
185399,Please optimize the molecule Cc1cc(C)cc(NC(=O)[C@@H]2CSc3ncc(C)c(=O)n3C2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=O)[C@@H]2CSc3ncc(C)c(=O)n3C2)c1,2.529160000000001
209139,Modify the molecule COc1cccc2cc(C(=O)NC[C@@](C)(O)CCSC)oc12 to have a lower LogP value.,COc1cccc2cc(C(=O)NC[C@@](C)(O)CCSC)oc12,2.675300000000001
229178,Modify the molecule CCCCN(C)C(=O)c1cn(Cc2cccnc2)nn1 to have a higher LogP value.,CCCCN(C)C(=O)c1cn(Cc2cccnc2)nn1,1.5935
14946,Modify the molecule CCCNC(=O)c1cccc(C(=O)NNC(=O)c2cccc(C#N)c2)c1 to have a higher LogP value.,CCCNC(=O)c1cccc(C(=O)NNC(=O)c2cccc(C#N)c2)c1,1.7728799999999996
18152,Modify the molecule Cc1noc(C)c1CCC(=O)N1CCC2(CC1)Nc1ccccc1S(=O)(=O)N2 to decrease its LogP value.,Cc1noc(C)c1CCC(=O)N1CCC2(CC1)Nc1ccccc1S(=O)(=O)N2,1.9467399999999997
49996,Please optimize the molecule CCc1ccc(O)c(C(=O)N2CCN(Cc3nc(-c4cccc(C(F)(F)F)c4)no3)CC2)c1 to have a higher LogP value.,CCc1ccc(O)c(C(=O)N2CCN(Cc3nc(-c4cccc(C(F)(F)F)c4)no3)CC2)c1,3.9814000000000034
109653,Modify the molecule O=C1Nc2ccccc2/C1=C\c1cccc(F)c1 to have a lower LogP value.,O=C1Nc2ccccc2/C1=C\c1cccc(F)c1,3.3184000000000013
105514,Optimize the molecule Cc1ccc(OCc2ccc(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)o2)cc1 to have a higher LogP value.,Cc1ccc(OCc2ccc(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)o2)cc1,4.485020000000004
187716,Please modify the molecule O=C1CCC[C@H]1CCOc1ccc(C(F)(F)F)cc1 to increase its LogP value.,O=C1CCC[C@H]1CCOc1ccc(C(F)(F)F)cc1,3.8435000000000032
61988,Please modify the molecule C[C@H](c1ccccc1)[NH+]1CC[C@H](NC[C@](C)(O)c2ccco2)C1 to increase its LogP value.,C[C@H](c1ccccc1)[NH+]1CC[C@H](NC[C@](C)(O)c2ccco2)C1,1.4950999999999999
193069,Optimize the molecule O=[N+]([O-])c1ccc(C2=NOc3cc(Cl)ccc3N2)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc(C2=NOc3cc(Cl)ccc3N2)cc1,3.4143000000000017
157849,Optimize the molecule COc1ccc(-n2nnnc2SCC(=O)Nc2ccc(F)cc2)c(OC)c1 to have a lower LogP value.,COc1ccc(-n2nnnc2SCC(=O)Nc2ccc(F)cc2)c(OC)c1,2.5494000000000003
137407,Please modify the molecule Cc1nc2c(s1)[C@H](N(C)C(=O)NCCn1cccc1)CCC2 to increase its LogP value.,Cc1nc2c(s1)[C@H](N(C)C(=O)NCCn1cccc1)CCC2,2.9720200000000014
201069,Optimize the molecule C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)COC(=O)C=C1CCCCC1 to have a higher LogP value.,C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)COC(=O)C=C1CCCCC1,3.184000000000002
200600,Modify the molecule CCC(CC)(NC(=O)Cc1c(F)cccc1F)/C(N)=N/O to have a lower LogP value.,CCC(CC)(NC(=O)Cc1c(F)cccc1F)/C(N)=N/O,1.9286999999999999
235503,Please modify the molecule COc1cccc(-c2nnc(S[C@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)n2C)c1 to decrease its LogP value.,COc1cccc(-c2nnc(S[C@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)n2C)c1,4.628800000000004
50593,Modify the molecule C[C@H](Nc1nc2c(N)cccc2o1)[C@H]1CCCO1 to decrease its LogP value.,C[C@H](Nc1nc2c(N)cccc2o1)[C@H]1CCCO1,2.3894
84146,Please optimize the molecule CN(CCC#N)C(=O)CC[NH+]1CCC(N2CCC[C@H]2C(N)=O)CC1 to have a higher LogP value.,CN(CCC#N)C(=O)CC[NH+]1CCC(N2CCC[C@H]2C(N)=O)CC1,-1.2544199999999943
238291,Optimize the molecule O=C(NCCc1ccc(F)cc1)c1ccc2c(=O)[nH][nH]c(=O)c2c1 to have a lower LogP value.,O=C(NCCc1ccc(F)cc1)c1ccc2c(=O)[nH][nH]c(=O)c2c1,1.3279999999999996
107609,Optimize the molecule CC(C)C(=O)NC[C@@H]1CCCN(C(=O)[C@@H]2Cc3cc(F)ccc3O2)C1 to have a higher LogP value.,CC(C)C(=O)NC[C@@H]1CCCN(C(=O)[C@@H]2Cc3cc(F)ccc3O2)C1,2.1399999999999997
105448,Modify the molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Cl)cc2)o1 to have a lower LogP value.,Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Cl)cc2)o1,2.80222
90107,Optimize the molecule CC[NH+]1CCC[C@H](NS(=O)(=O)C[C@@H](C)CCl)C1 to have a lower LogP value.,CC[NH+]1CCC[C@H](NS(=O)(=O)C[C@@H](C)CCl)C1,-0.15209999999999857
246589,Please optimize the molecule Cc1cc2ncn(CC3CCN(C(=O)C(C)(C)CCl)CC3)c2cc1C to have a lower LogP value.,Cc1cc2ncn(CC3CCN(C(=O)C(C)(C)CCl)CC3)c2cc1C,4.156740000000004
69756,Please optimize the molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)Cc3ccccc3F)CC2)c(-c2cccnc2)n1 to have a higher LogP value.,Cn1cc(S(=O)(=O)N2CCN(C(=O)Cc3ccccc3F)CC2)c(-c2cccnc2)n1,1.6968
58938,Modify the molecule O=C(CCC1CCCCC1)NNC(=O)C1CCC1 to have a lower LogP value.,O=C(CCC1CCCCC1)NNC(=O)C1CCC1,2.2944000000000004
86904,Modify the molecule CCc1cnc(NC(=O)CNC(=O)c2ccccn2)s1 to have a higher LogP value.,CCc1cnc(NC(=O)CNC(=O)c2ccccn2)s1,1.4689999999999999
245509,Please modify the molecule Cc1cc(C[NH2+]Cc2c(C)nn(C)c2C)cc(C)c1F to decrease its LogP value.,Cc1cc(C[NH2+]Cc2c(C)nn(C)c2C)cc(C)c1F,2.0564799999999996
226570,Optimize the molecule CCN(CC(=O)N(C)C)C(=O)c1ccnc(N2CCCC[C@@H]2C)c1 to have a lower LogP value.,CCN(CC(=O)N(C)C)C(=O)c1ccnc(N2CCCC[C@@H]2C)c1,2.0107
212412,Modify the molecule COc1ccc2c(c1)CCN(S(=O)(=O)CCNC(=O)c1cc(OC)ccc1Br)C2 to have a higher LogP value.,COc1ccc2c(c1)CCN(S(=O)(=O)CCNC(=O)c1cc(OC)ccc1Br)C2,2.584200000000001
220718,Modify the molecule CCc1c(C(=O)NC[C@@H]2COc3ccccc3O2)c(=O)cc(C)n1CC[NH+]1CCCCC1 to increase its LogP value.,CCc1c(C(=O)NC[C@@H]2COc3ccccc3O2)c(=O)cc(C)n1CC[NH+]1CCCCC1,1.357720000000001
193122,Modify the molecule CCC1(CNC(=O)C(=O)Nc2cc(C)c(Cl)cc2OC)CC1 to increase its LogP value.,CCC1(CNC(=O)C(=O)Nc2cc(C)c(Cl)cc2OC)CC1,2.9019200000000014
14443,Please modify the molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N2CCCCCC2)O1 to increase its LogP value.,[NH3+]C[C@H]1CC[C@@H](C(=O)N2CCCCCC2)O1,0.17849999999999921
42391,Please optimize the molecule COC(=O)[C@@H]1CCCCC[C@@H]1NC(=O)c1cnc2c(C)cccn2c1=O to have a higher LogP value.,COC(=O)[C@@H]1CCCCC[C@@H]1NC(=O)c1cnc2c(C)cccn2c1=O,1.85462
239057,Modify the molecule C[C@@H](Sc1n[nH]c(N)n1)C(=O)Nc1ccc2ccccc2c1 to decrease its LogP value.,C[C@@H](Sc1n[nH]c(N)n1)C(=O)Nc1ccc2ccccc2c1,2.6594000000000007
214025,Modify the molecule Cc1noc2nc(C(C)C)cc(C(=O)N(C)C(C)C)c12 to increase its LogP value.,Cc1noc2nc(C(C)C)cc(C(=O)N(C)C(C)C)c12,3.1350200000000017
144603,Modify the molecule CC[C@H](C(=O)Nc1c(C)noc1C)n1ccc(C(=O)Nc2c(C)noc2C)n1 to decrease its LogP value.,CC[C@H](C(=O)Nc1c(C)noc1C)n1ccc(C(=O)Nc2c(C)noc2C)n1,2.9348800000000006
214199,Optimize the molecule C[C@H]1CC(C(=O)OC2CCN(CC(F)(F)F)CC2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CC(C(=O)OC2CCN(CC(F)(F)F)CC2)C[C@H](C)O1,2.759900000000001
128405,Optimize the molecule CCO[C@@H]1CCC[NH+](Cc2ncc(-c3ccc(F)cc3)o2)C1 to have a lower LogP value.,CCO[C@@H]1CCC[NH+](Cc2ncc(-c3ccc(F)cc3)o2)C1,2.0645
101575,Optimize the molecule C[C@H]([NH2+][C@@H]1CCCN(c2cccnn2)C1)c1ccc2c(c1)OCCCO2 to have a higher LogP value.,C[C@H]([NH2+][C@@H]1CCCN(c2cccnn2)C1)c1ccc2c(c1)OCCCO2,1.9312999999999998
105470,Please optimize the molecule CCn1c(C)cn2c3c(=O)n(Cc4c(Cl)cccc4Cl)c(=O)n(C)c3nc12 to have a higher LogP value.,CCn1c(C)cn2c3c(=O)n(Cc4c(Cl)cccc4Cl)c(=O)n(C)c3nc12,2.832820000000001
212284,Please modify the molecule Cc1ccc(C2=NO[C@@H](Cn3nnc4ccccc43)C2)cc1 to decrease its LogP value.,Cc1ccc(C2=NO[C@@H](Cn3nnc4ccccc43)C2)cc1,2.932920000000001
135862,Please optimize the molecule CC(C)(C)OC(=O)[C@H]1CC[C@]1([NH3+])C(=O)[O-] to have a lower LogP value.,CC(C)(C)OC(=O)[C@H]1CC[C@]1([NH3+])C(=O)[O-],-1.5312999999999972
64745,Modify the molecule C[C@H]1C(=O)N2CCC[C@@H]2C(=O)N1C1CCC(C)(C)CC1 to have a lower LogP value.,C[C@H]1C(=O)N2CCC[C@@H]2C(=O)N1C1CCC(C)(C)CC1,2.1769
151719,Modify the molecule Cc1ccc(Cl)cc1NC(=O)C(=O)N1CCO[C@@H](C)C1 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)C(=O)N1CCO[C@@H](C)C1,1.8342199999999995
50523,Please modify the molecule COCCCNC(=O)c1ccc(-n2ccnn2)cc1 to decrease its LogP value.,COCCCNC(=O)c1ccc(-n2ccnn2)cc1,1.0335999999999994
43846,Optimize the molecule Cn1nnnc1SCC[NH2+]C1CCN(c2ncnc3[nH]cnc23)CC1 to have a higher LogP value.,Cn1nnnc1SCC[NH2+]C1CCN(c2ncnc3[nH]cnc23)CC1,-0.7990999999999986
210645,Modify the molecule O=C(NCc1ccccc1COCc1ccccc1)c1cc2ccoc2cn1 to have a lower LogP value.,O=C(NCc1ccccc1COCc1ccccc1)c1cc2ccoc2cn1,4.474600000000004
68213,Please optimize the molecule N#CC1=C(N)Oc2cc(OC(=O)c3ccc(F)cc3)ccc2[C@@H]1c1cccc(F)c1 to have a higher LogP value.,N#CC1=C(N)Oc2cc(OC(=O)c3ccc(F)cc3)ccc2[C@@H]1c1cccc(F)c1,4.402180000000002
132297,Modify the molecule CCC1(CC)CC[NH+](CC[NH2+]C[C@@H]2CCOC2)C1 to have a lower LogP value.,CCC1(CC)CC[NH+](CC[NH2+]C[C@@H]2CCOC2)C1,-0.318699999999996
221301,Modify the molecule CCN1CCC[C@H]1C[NH+](Cc1ccncc1)Cc1cccc2ccccc12 to have a higher LogP value.,CCN1CCC[C@H]1C[NH+](Cc1ccncc1)Cc1cccc2ccccc12,3.3042000000000025
199463,Modify the molecule C[C@H]1C[C@@H](N[C@@H]2CC(=O)N(CC(F)(F)F)C2)CC[NH+]1Cc1ccccc1 to have a higher LogP value.,C[C@H]1C[C@@H](N[C@@H]2CC(=O)N(CC(F)(F)F)C2)CC[NH+]1Cc1ccccc1,1.3752000000000004
146700,Please optimize the molecule COc1cccc(OC[C@H]2CCCN(C(=O)c3ncoc3C3CC3)C2)c1 to have a lower LogP value.,COc1cccc(OC[C@H]2CCCN(C(=O)c3ncoc3C3CC3)C2)c1,3.4918000000000022
54151,Modify the molecule COc1c(C[NH2+]CCCn2cnc3ccccc32)c(C)nn1C to have a lower LogP value.,COc1c(C[NH2+]CCCn2cnc3ccccc32)c(C)nn1C,1.2405199999999992
22216,Please optimize the molecule C[C@H]1C[C@@H]1NC(=O)C(=O)Nc1cccc(Oc2ccc(C#N)cc2)c1 to have a higher LogP value.,C[C@H]1C[C@@H]1NC(=O)C(=O)Nc1cccc(Oc2ccc(C#N)cc2)c1,2.8136800000000006
93110,Please modify the molecule N#CCC(=O)NNC(=O)c1ccccc1C(=O)[O-] to decrease its LogP value.,N#CCC(=O)NNC(=O)c1ccccc1C(=O)[O-],-1.27522
43339,Please optimize the molecule CC(C)C[C@H](C)N(C)C(=O)COc1cccc(F)c1 to have a lower LogP value.,CC(C)C[C@H](C)N(C)C(=O)COc1cccc(F)c1,3.097500000000002
183810,Modify the molecule Cc1ccc(C[n+]2ccccc2NC(=O)c2ccnc(NC3CC3)c2)cc1 to decrease its LogP value.,Cc1ccc(C[n+]2ccccc2NC(=O)c2ccnc(NC3CC3)c2)cc1,3.5524200000000015
232840,Optimize the molecule Cn1cnnc1CNC(=O)NNC(=O)c1cccs1 to have a higher LogP value.,Cn1cnnc1CNC(=O)NNC(=O)c1cccs1,0.020799999999999763
100133,Modify the molecule COc1cc2c(cc1OC)CN(C(=O)CCC(=O)c1ccc3c(c1)CCC3)CC2 to have a lower LogP value.,COc1cc2c(cc1OC)CN(C(=O)CCC(=O)c1ccc3c(c1)CCC3)CC2,3.740300000000003
69138,Optimize the molecule COC(=O)c1c([O-])n(O)c2ccc(OC)cc2[n+]1=O to have a lower LogP value.,COC(=O)c1c([O-])n(O)c2ccc(OC)cc2[n+]1=O,-0.33810000000000007
48904,Modify the molecule CC(C)(C)C(=O)NC[C@H]1CCCN(c2ncccc2Cl)C1 to increase its LogP value.,CC(C)(C)C(=O)NC[C@H]1CCCN(c2ncccc2Cl)C1,3.1137000000000015
136071,Please modify the molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1ncccc1C(F)(F)F to increase its LogP value.,COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1ncccc1C(F)(F)F,2.5620000000000003
184106,Modify the molecule O=C(NNc1ccccc1Cl)N[C@@H]1CCC[C@@H](C(F)(F)F)C1 to have a lower LogP value.,O=C(NNc1ccccc1Cl)N[C@@H]1CCC[C@@H](C(F)(F)F)C1,4.087200000000003
109806,Modify the molecule COc1ccccc1C[NH+]1CCC([C@H](NC(=O)c2ccccn2)c2nccs2)CC1 to decrease its LogP value.,COc1ccccc1C[NH+]1CCC([C@H](NC(=O)c2ccccn2)c2nccs2)CC1,2.5129
190349,Modify the molecule O=C(CCc1ccc2c(c1)OCCCO2)O[C@H]1CCOC1 to have a lower LogP value.,O=C(CCc1ccc2c(c1)OCCCO2)O[C@H]1CCOC1,2.1125999999999996
69055,Please optimize the molecule O=C([C@@H](c1ccccc1)N1CC[NH+]([C@@H]2CCS(=O)(=O)C2)CC1)N1CCCC1 to have a higher LogP value.,O=C([C@@H](c1ccccc1)N1CC[NH+]([C@@H]2CCS(=O)(=O)C2)CC1)N1CCCC1,-0.26229999999999687
106245,Modify the molecule CC1=C[C@H](NC(=O)CS[C@@H]2Nc3ccccc3C(=O)N2NS(=O)(=O)c2ccc(C)cc2)N=N1 to have a higher LogP value.,CC1=C[C@H](NC(=O)CS[C@@H]2Nc3ccccc3C(=O)N2NS(=O)(=O)c2ccc(C)cc2)N=N1,2.5849200000000003
201553,Please modify the molecule C[C@@H]([C@@H](C)O)[NH+](C)[C@@H]1CCC[C@@H]1C[NH3+] to decrease its LogP value.,C[C@@H]([C@@H](C)O)[NH+](C)[C@@H]1CCC[C@@H]1C[NH3+],-1.3189999999999966
197163,Please modify the molecule O=C1c2ccccc2N[C@@H](c2ccc(OCc3cn4ccccc4n3)cc2)N1C[C@H]1CCCO1 to decrease its LogP value.,O=C1c2ccccc2N[C@@H](c2ccc(OCc3cn4ccccc4n3)cc2)N1C[C@H]1CCCO1,4.658800000000003
109655,Optimize the molecule Cc1nn(-c2ccccc2)c(Oc2ccc(F)cc2)c1C[NH2+]C[C@H]1CCCO1 to have a lower LogP value.,Cc1nn(-c2ccccc2)c(Oc2ccc(F)cc2)c1C[NH2+]C[C@H]1CCCO1,3.3545200000000017
161712,Optimize the molecule CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1 to have a higher LogP value.,CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1,3.9719000000000033
51244,Optimize the molecule CCc1onc(C)c1NC(=O)C[C@H](C)SC to have a lower LogP value.,CCc1onc(C)c1NC(=O)C[C@H](C)SC,2.6255200000000007
99489,Optimize the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C to have a higher LogP value.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C,3.8442400000000028
17996,Modify the molecule CC(C)Oc1ccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)cc1C#N to have a higher LogP value.,CC(C)Oc1ccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)cc1C#N,3.997780000000003
141762,Please optimize the molecule Cc1ccc(-c2ncco2)cc1NC(=O)N1CCOC(C)(C)C1 to have a higher LogP value.,Cc1ccc(-c2ncco2)cc1NC(=O)N1CCOC(C)(C)C1,3.292720000000002
171710,Modify the molecule COc1ccc(OCCN(C)C(=O)C(=O)Nc2ccc(C)cc2)cc1 to increase its LogP value.,COc1ccc(OCCN(C)C(=O)C(=O)Nc2ccc(C)cc2)cc1,2.479520000000001
159272,Please modify the molecule Cc1nc2ccccc2n1CCNC(=O)CCNC(=O)c1cccs1 to increase its LogP value.,Cc1nc2ccccc2n1CCNC(=O)CCNC(=O)c1cccs1,2.3425200000000004
59408,Optimize the molecule Cc1cc([C@]2(C)NC(=O)N(Cc3cccc4cccnc34)C2=O)c(C)o1 to have a higher LogP value.,Cc1cc([C@]2(C)NC(=O)N(Cc3cccc4cccnc34)C2=O)c(C)o1,3.4118400000000024
153819,Please modify the molecule CNC(=O)[C@@H](C)CN(C)C(=O)Nc1ccc(CCN2CCOCC2)cc1 to increase its LogP value.,CNC(=O)[C@@H](C)CN(C)C(=O)Nc1ccc(CCN2CCOCC2)cc1,1.4071000000000005
93261,Please modify the molecule C[C@H](O/N=C(/N)c1cccs1)C(=O)N1CCN(c2ccccc2)CC1 to decrease its LogP value.,C[C@H](O/N=C(/N)c1cccs1)C(=O)N1CCN(c2ccccc2)CC1,2.1223
89005,Please modify the molecule Cc1cccc(CN[C@H](C)c2nc(C)cs2)n1 to decrease its LogP value.,Cc1cccc(CN[C@H](C)c2nc(C)cs2)n1,3.005740000000001
112658,Modify the molecule CC(=O)Nc1ccc(C)c(NC(=O)N2CCCSCC2)c1 to have a higher LogP value.,CC(=O)Nc1ccc(C)c(NC(=O)N2CCCSCC2)c1,2.924220000000001
61767,Modify the molecule COC(=O)c1ccc(NC(=O)[C@@H](C)n2nc(-c3ccc(C)cc3)ccc2=O)cc1 to decrease its LogP value.,COC(=O)c1ccc(NC(=O)[C@@H](C)n2nc(-c3ccc(C)cc3)ccc2=O)cc1,3.205020000000002
77445,Please modify the molecule Cc1n[nH]c2ncc(NC(=O)NCCCC[NH+]3CCCC[C@H]3C)cc12 to increase its LogP value.,Cc1n[nH]c2ncc(NC(=O)NCCCC[NH+]3CCCC[C@H]3C)cc12,1.6253199999999997
40354,Optimize the molecule C=CCNC(=S)Nc1sc2c(c1C(N)=O)CCCC2 to have a higher LogP value.,C=CCNC(=S)Nc1sc2c(c1C(N)=O)CCCC2,2.1982
77546,Please modify the molecule COc1ccc(N[C@@H](C)C(=O)N[C@H]2CCOc3ccccc32)cn1 to increase its LogP value.,COc1ccc(N[C@@H](C)C(=O)N[C@H]2CCOc3ccccc32)cn1,2.5306000000000006
27018,Please optimize the molecule Cc1nn(C)c(C)c1CNC[C@H](c1cccs1)[NH+]1CCCC1 to have a higher LogP value.,Cc1nn(C)c(C)c1CNC[C@H](c1cccs1)[NH+]1CCCC1,1.60804
154485,Modify the molecule O=C([O-])c1cc(NS(=O)(=O)c2cccc(F)c2)ccc1N1CCSCC1 to decrease its LogP value.,O=C([O-])c1cc(NS(=O)(=O)c2cccc(F)c2)ccc1N1CCSCC1,1.5432
24787,Modify the molecule O=C1c2ccccc2N[C@H](c2cccc(Br)c2)N1Cc1ccco1 to have a higher LogP value.,O=C1c2ccccc2N[C@H](c2cccc(Br)c2)N1Cc1ccco1,4.808800000000003
46165,Modify the molecule COC1CC[NH+](CCNC(=O)[C@H]2CCCS2)CC1 to decrease its LogP value.,COC1CC[NH+](CCNC(=O)[C@H]2CCCS2)CC1,-0.30809999999999715
195474,Please optimize the molecule C[NH+](C)C[C@@H](O)CNC(=O)c1ccccc1Br to have a lower LogP value.,C[NH+](C)C[C@@H](O)CNC(=O)c1ccccc1Br,-0.3156999999999994
197054,Please modify the molecule CC(C)(C)CC(C)(C)[NH2+]Cc1ncn(-c2ccccc2)n1 to increase its LogP value.,CC(C)(C)CC(C)(C)[NH2+]Cc1ncn(-c2ccccc2)n1,2.5455000000000005
126353,Please modify the molecule CC(C)(C)c1nc(CNc2ccc(OC(F)F)cn2)no1 to increase its LogP value.,CC(C)(C)c1nc(CNc2ccc(OC(F)F)cn2)no1,2.975600000000001
167479,Please modify the molecule CC(C)n1cc(C(=O)NCC2CCCCC2)c(=O)c(C(=O)N2C[C@H](C)O[C@H](C)C2)c1 to decrease its LogP value.,CC(C)n1cc(C(=O)NCC2CCCCC2)c(=O)c(C(=O)N2C[C@H](C)O[C@H](C)C2)c1,2.9887000000000015
220206,Modify the molecule CC1CCC(NC(=O)[C@H]2CCCN(S(=O)(=O)c3c[nH]c(C(=O)N4CCCC4)c3)C2)CC1 to have a higher LogP value.,CC1CCC(NC(=O)[C@H]2CCCN(S(=O)(=O)c3c[nH]c(C(=O)N4CCCC4)c3)C2)CC1,2.3462999999999994
141243,Please modify the molecule CCc1nn(C)c(OC)c1CNC(=O)NC[C@@H]1CCO[C@@H]1C(C)C to increase its LogP value.,CCc1nn(C)c(OC)c1CNC(=O)NC[C@@H]1CCO[C@@H]1C(C)C,1.8514
194006,Optimize the molecule COc1ncnc(NCc2c(C)noc2C)c1[N+](=O)[O-] to have a lower LogP value.,COc1ncnc(NCc2c(C)noc2C)c1[N+](=O)[O-],1.6103399999999999
201393,Optimize the molecule COC(=O)[C@H](C)Sc1nc2ccc(Br)cc2c(=O)n1CC(C)C to have a lower LogP value.,COC(=O)[C@H](C)Sc1nc2ccc(Br)cc2c(=O)n1CC(C)C,3.468600000000002
50691,Please optimize the molecule CC[C@@H]1S/C(=N\c2cccc(Cl)c2)NC1=O to have a higher LogP value.,CC[C@@H]1S/C(=N\c2cccc(Cl)c2)NC1=O,2.969100000000001
95893,Please modify the molecule CC(=O)c1ccc(OCCSCC(C)C)cc1 to increase its LogP value.,CC(=O)c1ccc(OCCSCC(C)C)cc1,3.6572000000000022
44766,Optimize the molecule COCC1CC[NH+]([C@@H]2CCC[C@@]([NH3+])(C(=O)[O-])C2)CC1 to have a higher LogP value.,COCC1CC[NH+]([C@@H]2CCC[C@@]([NH3+])(C(=O)[O-])C2)CC1,-2.3990999999999945
167835,Modify the molecule CCc1cnc(C)nc1N(C)Cc1cnn(C)c1C to decrease its LogP value.,CCc1cnc(C)nc1N(C)Cc1cnn(C)c1C,2.02574
114681,Please modify the molecule CCC(=O)N1CCC[C@H](C(=O)Oc2cccc(C(=O)N(C)C)c2)C1 to decrease its LogP value.,CCC(=O)N1CCC[C@H](C(=O)Oc2cccc(C(=O)N(C)C)c2)C1,1.9424000000000001
117099,Modify the molecule CC(C)[C@H](C)NC(=O)c1cccc(SCC#N)c1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)c1cccc(SCC#N)c1,3.0765800000000016
207050,Optimize the molecule C[C@@H](CNC(=O)N1CCC(OC[C@H]2CCCO2)CC1)C[NH+]1CCCCC1 to have a higher LogP value.,C[C@@H](CNC(=O)N1CCC(OC[C@H]2CCCO2)CC1)C[NH+]1CCCCC1,1.060900000000002
97465,Modify the molecule CC[C@@H](Nc1ccc2nnc(C)n2n1)c1nc(C(F)(F)F)cs1 to decrease its LogP value.,CC[C@@H](Nc1ccc2nnc(C)n2n1)c1nc(C(F)(F)F)cs1,3.4712200000000015
204469,Please modify the molecule CC(C)[NH2+]C[C@@H](C)C(=O)OC(C)(C)C to increase its LogP value.,CC(C)[NH2+]C[C@@H](C)C(=O)OC(C)(C)C,0.9359999999999997
214116,Optimize the molecule CCn1c(S[C@@H](C)c2nc3ccccc3c(=O)[nH]2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 to have a higher LogP value.,CCn1c(S[C@@H](C)c2nc3ccccc3c(=O)[nH]2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21,3.166900000000002
119839,Please optimize the molecule Cc1nn(C)cc1[C@H](C)NC(=O)N1CCC(OCC(C)C)CC1 to have a lower LogP value.,Cc1nn(C)cc1[C@H](C)NC(=O)N1CCC(OCC(C)C)CC1,2.636120000000001
78999,Optimize the molecule C[C@H]1CC([NH+]2CCN([C@@H](C)C(F)(F)F)CC2)C[C@@H](C)O1 to have a higher LogP value.,C[C@H]1CC([NH+]2CCN([C@@H](C)C(F)(F)F)CC2)C[C@@H](C)O1,1.0937000000000001
172964,Optimize the molecule NC(=O)C[C@@H](NC(=O)c1cccc(C(=O)N2CCCC2)n1)C1CCCCC1 to have a lower LogP value.,NC(=O)C[C@@H](NC(=O)c1cccc(C(=O)N2CCCC2)n1)C1CCCCC1,1.8716999999999986
156126,Please modify the molecule CSc1nc(N2CCOCC2)c2cnn(CCNC(=O)Cc3cccc(C)c3)c2n1 to increase its LogP value.,CSc1nc(N2CCOCC2)c2cnn(CCNC(=O)Cc3cccc(C)c3)c2n1,2.0521199999999995
246966,Modify the molecule CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21 to increase its LogP value.,CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21,0.27650000000000047
242542,Optimize the molecule C[C@H](CO)[NH2+]CCCOc1cccnc1 to have a higher LogP value.,C[C@H](CO)[NH2+]CCCOc1cccnc1,-0.20530000000000026
28405,Modify the molecule COC(=O)c1cc(-c2ccc(/C=C3\C(=O)N(c4ccccc4)N=C3C)o2)ccc1Cl to have a higher LogP value.,COC(=O)c1cc(-c2ccc(/C=C3\C(=O)N(c4ccccc4)N=C3C)o2)ccc1Cl,5.192700000000004
50974,Please optimize the molecule CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1 to have a lower LogP value.,CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1,1.7013
76409,Please modify the molecule Cn1ncnc1CNC(=O)N(CC[NH+](C)C)Cc1ccc(F)cc1F to increase its LogP value.,Cn1ncnc1CNC(=O)N(CC[NH+](C)C)Cc1ccc(F)cc1F,-0.05039999999999778
164832,Optimize the molecule COc1ccc(N2CCN(C(=O)c3ccccc3NC(=O)C3=C(C)OCCS3)CC2)cc1 to have a higher LogP value.,COc1ccc(N2CCN(C(=O)c3ccccc3NC(=O)C3=C(C)OCCS3)CC2)cc1,3.591000000000002
125708,Modify the molecule Cc1cnc(CN2CC3(CCC2=O)CC[NH+](CCc2nccn2C)CC3)cn1 to have a lower LogP value.,Cc1cnc(CN2CC3(CCC2=O)CC[NH+](CCc2nccn2C)CC3)cn1,0.5487200000000023
223994,Please optimize the molecule CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)CSc2cccc[n+]2[O-])C1 to have a lower LogP value.,CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)CSc2cccc[n+]2[O-])C1,2.8393000000000015
242209,Modify the molecule C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H]1CSC(=O)N1 to increase its LogP value.,C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H]1CSC(=O)N1,2.5776000000000003
4915,Modify the molecule O=C(Nc1ccccc1C(=O)NCc1ccccc1)c1cnc2ccccc2n1 to have a lower LogP value.,O=C(Nc1ccccc1C(=O)NCc1ccccc1)c1cnc2ccccc2n1,3.812100000000002
169655,Please optimize the molecule C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1 to have a lower LogP value.,C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1,3.802000000000003
48611,Please modify the molecule CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1 to decrease its LogP value.,CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1,3.427900000000002
159363,Modify the molecule Cc1ccc(NC(=O)Cc2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1C to have a higher LogP value.,Cc1ccc(NC(=O)Cc2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1C,3.6592400000000023
143556,Modify the molecule CSC[C@H]1CCN(C(=O)Nc2ccc(Br)nc2C)C1 to decrease its LogP value.,CSC[C@H]1CCN(C(=O)Nc2ccc(Br)nc2C)C1,3.369320000000002
187677,Please optimize the molecule CC(C)(C)C(=O)N1CCC(C(=O)OCCCc2ccccc2)CC1 to have a lower LogP value.,CC(C)(C)C(=O)N1CCC(C(=O)OCCCc2ccccc2)CC1,3.4471000000000025
173163,Modify the molecule CCCC(CCC)CC(=O)N1CCC[C@H]1c1c(C)n[nH]c1C to increase its LogP value.,CCCC(CCC)CC(=O)N1CCC[C@H]1c1c(C)n[nH]c1C,4.296540000000004
58506,Please optimize the molecule C/[NH+]=C(/NCCC(=O)Nc1ccc(C)cn1)N1CCC[C@@H](C)C1 to have a higher LogP value.,C/[NH+]=C(/NCCC(=O)Nc1ccc(C)cn1)N1CCC[C@@H](C)C1,0.10652000000000106
35627,Modify the molecule O=[N+]([O-])c1ccc(-n2nnnc2SCc2cccc(Cl)c2)cc1 to decrease its LogP value.,O=[N+]([O-])c1ccc(-n2nnnc2SCc2cccc(Cl)c2)cc1,3.516200000000002
57528,Please modify the molecule CCc1c(C)nc(SCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)[nH]c1=O to increase its LogP value.,CCc1c(C)nc(SCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)[nH]c1=O,3.5036200000000015
28769,Please optimize the molecule CCc1cc2c(Nc3cnn(CC(=O)N(C)C)c3)ncnc2s1 to have a lower LogP value.,CCc1cc2c(Nc3cnn(CC(=O)N(C)C)c3)ncnc2s1,2.282
228088,Modify the molecule CC(C)(C)C(=O)CSc1nnc(-c2ccc3c(c2)OCO3)n1-c1ccccc1 to decrease its LogP value.,CC(C)(C)C(=O)CSc1nnc(-c2ccc3c(c2)OCO3)n1-c1ccccc1,4.370300000000004
166022,Optimize the molecule Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1 to have a higher LogP value.,Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1,2.5330200000000005
4593,Please optimize the molecule COc1ccc(/C=C2\SC(=O)N(CC(=O)NCC(=O)[O-])C2=O)cc1OC to have a lower LogP value.,COc1ccc(/C=C2\SC(=O)N(CC(=O)NCC(=O)[O-])C2=O)cc1OC,-0.3937999999999997
225543,Modify the molecule COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl to have a lower LogP value.,COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl,0.8723000000000001
225382,Modify the molecule CN(CC(=O)N1CCC(OCc2cccnc2)CC1)c1ccccc1 to increase its LogP value.,CN(CC(=O)N1CCC(OCc2cccnc2)CC1)c1ccccc1,2.7256
18138,Optimize the molecule Brc1c[nH]c(-c2nc(-c3cccs3)no2)c1 to have a lower LogP value.,Brc1c[nH]c(-c2nc(-c3cccs3)no2)c1,3.5557000000000007
122531,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)[C@@H](C)S(=O)(=O)c2nccn2C)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)[C@@H](C)S(=O)(=O)c2nccn2C)C1,1.0867999999999998
78340,Modify the molecule C#CCN[C@H]1CCCC[C@H]1[C@@H]1CCCC[NH2+]1 to increase its LogP value.,C#CCN[C@H]1CCCC[C@H]1[C@@H]1CCCC[NH2+]1,0.8838999999999999
222825,Please optimize the molecule O=C(Cc1ccc([N+](=O)[O-])cc1)NC[C@H](c1cccs1)N1CCOCC1 to have a higher LogP value.,O=C(Cc1ccc([N+](=O)[O-])cc1)NC[C@H](c1cccs1)N1CCOCC1,2.3885000000000005
242709,Modify the molecule COC(=O)c1c(C)sc(-c2c(-c3ccc(OC)c(OC)c3)[nH]c3c2c(=O)n(C)c(=O)n3C)c1[O-] to increase its LogP value.,COC(=O)c1c(C)sc(-c2c(-c3ccc(OC)c(OC)c3)[nH]c3c2c(=O)n(C)c(=O)n3C)c1[O-],2.1466199999999986
103644,Optimize the molecule CN1C(=O)NC(=O)/C(=C2\C[C@H](c3cccs3)NN2)C1=O to have a higher LogP value.,CN1C(=O)NC(=O)/C(=C2\C[C@H](c3cccs3)NN2)C1=O,0.24939999999999973
206181,Modify the molecule COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1 to increase its LogP value.,COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1,3.8394400000000033
88722,Modify the molecule CSc1ccccc1C(=O)NNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12 to increase its LogP value.,CSc1ccccc1C(=O)NNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12,3.182400000000002
65830,Modify the molecule CCOc1cc2c(cc1NC(=O)Cc1csc(-c3ccsc3)n1)O[C@H](C)C2 to decrease its LogP value.,CCOc1cc2c(cc1NC(=O)Cc1csc(-c3ccsc3)n1)O[C@H](C)C2,4.774900000000004
5903,Please modify the molecule CO[C@@H](C[NH2+][C@H](C)C1CCOCC1)c1cccc(Cl)c1 to increase its LogP value.,CO[C@@H](C[NH2+][C@H](C)C1CCOCC1)c1cccc(Cl)c1,2.4060000000000006
42081,Optimize the molecule Cc1cccc(C(=O)NC2CCN(C(=O)NC3CCCCC3)CC2)c1 to have a lower LogP value.,Cc1cccc(C(=O)NC2CCN(C(=O)NC3CCCCC3)CC2)c1,3.2315200000000024
12873,Please optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)[C@@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1 to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)[C@@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1,4.213300000000003
141911,Modify the molecule COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1 to decrease its LogP value.,COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1,4.507900000000003
56346,Optimize the molecule CC(C)=CC(=O)N1CCC(n2nccc2NC(=O)c2ccc3c(c2)OCO3)CC1 to have a lower LogP value.,CC(C)=CC(=O)N1CCC(n2nccc2NC(=O)c2ccc3c(c2)OCO3)CC1,2.993800000000001
230978,Please modify the molecule CSCc1c(C(=O)Nc2cc(C)nn2-c2ccccc2F)oc2ccccc12 to increase its LogP value.,CSCc1c(C(=O)Nc2cc(C)nn2-c2ccccc2F)oc2ccccc12,5.181320000000004
49655,Modify the molecule COc1cccc(C(=O)N2CCN(C(=O)Cn3cnc4ccccc43)CC2)c1 to increase its LogP value.,COc1cccc(C(=O)N2CCN(C(=O)Cn3cnc4ccccc43)CC2)c1,2.029499999999999
85916,Please modify the molecule CC(C)CCn1nnnc1[C@H](C(C)C)[NH+]1CCN(c2ccccc2)CC1 to increase its LogP value.,CC(C)CCn1nnnc1[C@H](C(C)C)[NH+]1CCN(c2ccccc2)CC1,1.821400000000001
26276,Optimize the molecule COc1ccccc1NC(=O)CNc1cccc(C#Cc2ccccc2)c1 to have a lower LogP value.,COc1ccccc1NC(=O)CNc1cccc(C#Cc2ccccc2)c1,4.145600000000002
107095,Please modify the molecule C[NH+]1CCN(Cc2ccc(F)cc2Cl)CC1 to decrease its LogP value.,C[NH+]1CCN(Cc2ccc(F)cc2Cl)CC1,0.8093999999999999
84125,Please optimize the molecule CS[C@@H]1CC[C@@H](NC(=O)N2CCC(CC(=O)N3CC[NH+](C)CC3)CC2)C1 to have a lower LogP value.,CS[C@@H]1CC[C@@H](NC(=O)N2CCC(CC(=O)N3CC[NH+](C)CC3)CC2)C1,0.4391000000000027
55988,Please optimize the molecule CC(=O)Nc1cccc(NC(=O)c2cc(Cl)c[nH]2)c1C to have a lower LogP value.,CC(=O)Nc1cccc(NC(=O)c2cc(Cl)c[nH]2)c1C,3.187220000000001
231676,Modify the molecule CCCCS(=O)(=O)NCc1cn(C)nc1C to have a lower LogP value.,CCCCS(=O)(=O)NCc1cn(C)nc1C,0.9480200000000001
188426,Optimize the molecule CC[C@@H]1CCc2c(sc(NC(=O)COCC(=O)[O-])c2C(N)=O)C1 to have a higher LogP value.,CC[C@@H]1CCc2c(sc(NC(=O)COCC(=O)[O-])c2C(N)=O)C1,0.06690000000000051
140495,Please modify the molecule CN1C(=O)c2ccccc2[C@@H](C(=O)Nc2nnc(C3CCC3)s2)[C@H]1c1ccc2c(c1)OCO2 to increase its LogP value.,CN1C(=O)c2ccccc2[C@@H](C(=O)Nc2nnc(C3CCC3)s2)[C@H]1c1ccc2c(c1)OCO2,4.083500000000003
89474,Modify the molecule O=C(c1cc(Cl)ccn1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 to increase its LogP value.,O=C(c1cc(Cl)ccn1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1,2.605600000000001
93700,Please modify the molecule CCc1nc2ccccc2n1C[C@@H](O)COc1ccc(F)cc1 to increase its LogP value.,CCc1nc2ccccc2n1C[C@@H](O)COc1ccc(F)cc1,3.1777000000000015
90032,Modify the molecule Cc1cc(C)c2c(=O)cc(C(=O)N(Cc3ccc(Cl)cc3)[C@@H]3CCS(=O)(=O)C3)oc2c1 to increase its LogP value.,Cc1cc(C)c2c(=O)cc(C(=O)N(Cc3ccc(Cl)cc3)[C@@H]3CCS(=O)(=O)C3)oc2c1,3.8927400000000025
160815,Please modify the molecule C#Cc1cc(F)c(NC(=O)N[C@H]2CCCC[C@H]2C(N)=O)c(F)c1 to decrease its LogP value.,C#Cc1cc(F)c(NC(=O)N[C@H]2CCCC[C@H]2C(N)=O)c(F)c1,2.1117
18768,Please modify the molecule COC[C@@H](C)NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,COC[C@@H](C)NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1,1.0491
111722,Optimize the molecule COc1ccc(OC[C@H](C)NS(C)(=O)=O)cc1 to have a higher LogP value.,COc1ccc(OC[C@H](C)NS(C)(=O)=O)cc1,1.0116999999999998
215426,Please optimize the molecule C[C@@H]1OCC[C@H]1C(=O)N(C)Cc1nc2c(s1)CCCC2 to have a higher LogP value.,C[C@@H]1OCC[C@H]1C(=O)N(C)Cc1nc2c(s1)CCCC2,2.4053000000000004
4689,Optimize the molecule COc1ccc(-c2nc(CN3CCNC(=O)C3)c(C)o2)c2ccccc12 to have a lower LogP value.,COc1ccc(-c2nc(CN3CCNC(=O)C3)c(C)o2)c2ccccc12,2.743620000000001
132588,Modify the molecule COc1cccc(CC(=O)N2CCN(Cc3csc(C)n3)CC2)c1 to have a lower LogP value.,COc1cccc(CC(=O)N2CCN(Cc3csc(C)n3)CC2)c1,2.3470200000000006
82981,Please modify the molecule C=CCS(=O)(=O)NCCCO to decrease its LogP value.,C=CCS(=O)(=O)NCCCO,-0.5258
28437,Modify the molecule O=S1(=O)CC[C@@H](C2(O)[C@H]3CCC[C@H]32)C1 to decrease its LogP value.,O=S1(=O)CC[C@@H](C2(O)[C@H]3CCC[C@H]32)C1,0.5821000000000001
19617,Please optimize the molecule NC(=O)[C@H](c1ccc(F)cc1)N1CCCc2c(NC(=O)c3ccc(F)cc3)cccc21 to have a lower LogP value.,NC(=O)[C@H](c1ccc(F)cc1)N1CCCc2c(NC(=O)c3ccc(F)cc3)cccc21,4.1963000000000035
192894,Modify the molecule O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F to increase its LogP value.,O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F,1.6825999999999994
68209,Modify the molecule CCCNC(=O)CNC(=O)N1CCC[C@@H](COCC)C1 to have a higher LogP value.,CCCNC(=O)CNC(=O)N1CCC[C@@H](COCC)C1,0.9706999999999997
72203,Please optimize the molecule CCC(=O)Nc1ccc(Cl)c(NC(=O)N(C)Cc2cnn(C)c2)c1 to have a lower LogP value.,CCC(=O)Nc1ccc(Cl)c(NC(=O)N(C)Cc2cnn(C)c2)c1,3.0859000000000014
41275,Please modify the molecule CCC[C@H]([NH2+]C1CCN(S(=O)(=O)c2cnn(C)c2)CC1)C1CCCCC1 to decrease its LogP value.,CCC[C@H]([NH2+]C1CCN(S(=O)(=O)c2cnn(C)c2)CC1)C1CCCCC1,1.8856
110498,Please modify the molecule CN(Cc1ccccc1)C(=O)CSc1ncn[nH]1 to decrease its LogP value.,CN(Cc1ccccc1)C(=O)CSc1ncn[nH]1,1.5554
162862,Modify the molecule Cc1ccn2cc(-c3ccc(NC(=O)[C@H]4C[C@H]4C)cc3)nc2c1 to decrease its LogP value.,Cc1ccn2cc(-c3ccc(NC(=O)[C@H]4C[C@H]4C)cc3)nc2c1,3.9042200000000022
228787,Modify the molecule CC(C)Cn1ccnc(N[C@@H]2CC[C@@H]([NH+](C)C)C2)c1=O to decrease its LogP value.,CC(C)Cn1ccnc(N[C@@H]2CC[C@@H]([NH+](C)C)C2)c1=O,0.37680000000000113
219591,Modify the molecule O=C(Nc1ccccc1)NC1CCN(c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CC1 to have a higher LogP value.,O=C(Nc1ccccc1)NC1CCN(c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CC1,3.2935000000000016
59937,Please optimize the molecule Cc1ccc(NC(=O)c2n[nH]c3c2CCC3)cc1C(=O)N(C)C to have a lower LogP value.,Cc1ccc(NC(=O)c2n[nH]c3c2CCC3)cc1C(=O)N(C)C,2.16092
217629,Optimize the molecule O=C(NCC[C@H](O)c1ccccc1)Nc1ccc2c(c1)OCO2 to have a higher LogP value.,O=C(NCC[C@H](O)c1ccccc1)Nc1ccc2c(c1)OCO2,2.6605000000000008
61498,Modify the molecule Cc1ncc([C@@H](C)NCC2(c3ccccc3C)CC2)s1 to have a higher LogP value.,Cc1ncc([C@@H](C)NCC2(c3ccccc3C)CC2)s1,4.1423400000000035
108340,Please optimize the molecule CCOc1ccc(-c2[nH]ncc2C(=O)NCc2ccccn2)cc1Cl to have a lower LogP value.,CCOc1ccc(-c2[nH]ncc2C(=O)NCc2ccccn2)cc1Cl,3.453800000000001
209223,Please modify the molecule C[NH+](C)[C@H]1CCN(C(=O)C(=O)c2ccccc2)C[C@H]1CCC(=O)[O-] to decrease its LogP value.,C[NH+](C)[C@H]1CCN(C(=O)C(=O)c2ccccc2)C[C@H]1CCC(=O)[O-],-1.238999999999996
32650,Please optimize the molecule C[C@H](Cc1nnc(NC(=O)CC(C)(C)C)s1)c1ccccc1 to have a lower LogP value.,C[C@H](Cc1nnc(NC(=O)CC(C)(C)C)s1)c1ccccc1,4.259000000000003
217455,Modify the molecule O=C(Cc1c[nH]c2cc(Cl)ccc12)NC[C@H]1CN2CCCC[C@@H]2CO1 to increase its LogP value.,O=C(Cc1c[nH]c2cc(Cl)ccc12)NC[C@H]1CN2CCCC[C@@H]2CO1,2.7333000000000007
213943,Optimize the molecule Cc1ccc(N2C(=O)[C@@H]3[C@@H](N=NN3CC(=O)NCc3ccccc3Cl)C2=O)cc1C to have a higher LogP value.,Cc1ccc(N2C(=O)[C@@H]3[C@@H](N=NN3CC(=O)NCc3ccccc3Cl)C2=O)cc1C,2.56644
210609,Please modify the molecule CN(CC(C)(C)C)C(=O)c1cccc(C(=O)N[C@@H](CO)c2ccco2)c1 to decrease its LogP value.,CN(CC(C)(C)C)C(=O)c1cccc(C(=O)N[C@@H](CO)c2ccco2)c1,2.8611000000000013
57514,Please modify the molecule O=C(NC[C@H]1CC[NH+](C2CC2)C1)c1c[nH]c2nccc(Cl)c12 to increase its LogP value.,O=C(NC[C@H]1CC[NH+](C2CC2)C1)c1c[nH]c2nccc(Cl)c12,1.0133000000000003
121857,Please modify the molecule Nc1cc[nH+]cc1[C@@H](O)c1cncc(Br)c1 to decrease its LogP value.,Nc1cc[nH+]cc1[C@@H](O)c1cncc(Br)c1,1.3221
145006,Please optimize the molecule CCOc1ccc(CN2C(=O)c3ccccc3[C@H]2C(=O)NC[C@H]2CCCO2)cc1 to have a lower LogP value.,CCOc1ccc(CN2C(=O)c3ccccc3[C@H]2C(=O)NC[C@H]2CCCO2)cc1,3.0776000000000012
152038,Optimize the molecule Cc1[nH]c2ccccc2c1/C=C(/C#N)C(=O)NC1CCCC1 to have a lower LogP value.,Cc1[nH]c2ccccc2c1/C=C(/C#N)C(=O)NC1CCCC1,3.4421000000000017
113296,Please modify the molecule Cc1nc(C(=O)OC[C@@H]2CC(=O)N(C)[C@H]2c2cccc(Cl)c2)cs1 to increase its LogP value.,Cc1nc(C(=O)OC[C@@H]2CC(=O)N(C)[C@H]2c2cccc(Cl)c2)cs1,3.481320000000003
125328,Modify the molecule CCCCOc1ccc(CN2C(=O)C3(OCCCO3)c3c(C)ccc(C)c32)cc1OC to have a lower LogP value.,CCCCOc1ccc(CN2C(=O)C3(OCCCO3)c3c(C)ccc(C)c32)cc1OC,4.627440000000004
119613,Please modify the molecule C[C@H]1CCC[C@]2(CC1)C[NH+]=C(N)N2c1ccccc1F to decrease its LogP value.,C[C@H]1CCC[C@]2(CC1)C[NH+]=C(N)N2c1ccccc1F,1.3800000000000006
47369,Modify the molecule CC[C@@H]([NH3+])[C@H](c1ccccc1F)N1CCC(C)(C)C1 to have a higher LogP value.,CC[C@@H]([NH3+])[C@H](c1ccccc1F)N1CCC(C)(C)C1,2.6192
148525,Please optimize the molecule C=C(C)[C@@H](O)c1ccc2c(c1)OCO2 to have a higher LogP value.,C=C(C)[C@@H](O)c1ccc2c(c1)OCO2,2.0248
190964,Modify the molecule CCCn1nccc1C(=O)NC[C@@H](O)c1ccc(C(C)C)cc1 to have a higher LogP value.,CCCn1nccc1C(=O)NC[C@@H](O)c1ccc(C(C)C)cc1,2.879900000000001
194917,Modify the molecule COc1ccc2c(CC(=O)Oc3ccccc3C(F)(F)F)coc2c1 to have a higher LogP value.,COc1ccc2c(CC(=O)Oc3ccccc3C(F)(F)F)coc2c1,4.6083000000000025
118079,Please optimize the molecule COc1ncnc(NC[C@@H]2CCCC[C@@H]2C)c1[N+](=O)[O-] to have a higher LogP value.,COc1ncnc(NC[C@@H]2CCCC[C@@H]2C)c1[N+](=O)[O-],2.6316000000000006
138582,Please modify the molecule CC(=O)Oc1cc2c(C(=O)NCc3ccccc3)c(C)oc2c2ccccc12 to decrease its LogP value.,CC(=O)Oc1cc2c(C(=O)NCc3ccccc3)c(C)oc2c2ccccc12,4.7497200000000035
80386,Modify the molecule COc1cc(C(=O)NNC(=O)c2cc(-c3ccccc3)[nH]n2)cc(OC)c1C to have a lower LogP value.,COc1cc(C(=O)NNC(=O)c2cc(-c3ccccc3)[nH]n2)cc(OC)c1C,2.47712
587,Optimize the molecule O=C(Nc1cccc2ccccc12)NC1CC[NH+](CC(F)F)CC1 to have a lower LogP value.,O=C(Nc1cccc2ccccc12)NC1CC[NH+](CC(F)F)CC1,2.2737
89354,Please modify the molecule O=C(NCc1ccnc(OCC(F)F)c1)N1CCC[C@H]2CCC[C@H]21 to increase its LogP value.,O=C(NCc1ccnc(OCC(F)F)c1)N1CCC[C@H]2CCC[C@H]21,3.199600000000002
74193,Please modify the molecule COCCO[C@@H](C)C(=O)N1CCC(OC2CCCCC2)CC1 to decrease its LogP value.,COCCO[C@@H](C)C(=O)N1CCC(OC2CCCCC2)CC1,2.3781999999999996
216452,Modify the molecule CCC[NH2+][C@H](CC)c1ccc(-c2cscc2Br)cc1 to increase its LogP value.,CCC[NH2+][C@H](CC)c1ccc(-c2cscc2Br)cc1,4.602100000000003
95803,Modify the molecule O=C(NCC#CCOc1ccc2c(c1)OCO2)c1cccc(Br)c1 to have a lower LogP value.,O=C(NCC#CCOc1ccc2c(c1)OCO2)c1cccc(Br)c1,2.990000000000002
179010,Modify the molecule CCSc1sccc1[C@H]1C(C#N)=C(N)N(c2cc([N+](=O)[O-])ccc2C)C2=C1C(=O)CC(C)(C)C2 to have a lower LogP value.,CCSc1sccc1[C@H]1C(C#N)=C(N)N(c2cc([N+](=O)[O-])ccc2C)C2=C1C(=O)CC(C)(C)C2,6.017600000000004
109877,Please optimize the molecule COc1ncccc1C(=O)N1CCN(CCNC(=O)c2ccsc2)CC1 to have a lower LogP value.,COc1ncccc1C(=O)N1CCN(CCNC(=O)c2ccsc2)CC1,1.3394999999999997
105764,Please modify the molecule COC(=O)[C@@H]1C[NH+](Cc2ccc(F)cc2C)C[C@@H]1C to increase its LogP value.,COC(=O)[C@@H]1C[NH+](Cc2ccc(F)cc2C)C[C@@H]1C,0.9579199999999997
234574,Modify the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)[C@@H]3[C@@H](C(=O)[O-])[C@@H]4C=C[C@H]3C4)cc2)c1 to have a higher LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)[C@@H]3[C@@H](C(=O)[O-])[C@@H]4C=C[C@H]3C4)cc2)c1,2.0741999999999994
93491,Optimize the molecule Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)NCCCN1C[C@H](C)O[C@@H](C)C1 to have a lower LogP value.,Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)NCCCN1C[C@H](C)O[C@@H](C)C1,2.832440000000001
35436,Modify the molecule C[C@@H](C(=O)Nc1ccc(Cc2nc3ccccc3s2)cc1)[NH+]1CCN(c2ccc(O)cc2)CC1 to increase its LogP value.,C[C@@H](C(=O)Nc1ccc(Cc2nc3ccccc3s2)cc1)[NH+]1CCN(c2ccc(O)cc2)CC1,3.3248000000000015
82562,Please modify the molecule Cc1cc(=O)n(CC(=O)Nc2ccc(C)c(Cl)c2)c(-n2nc(C)cc2C)n1 to increase its LogP value.,Cc1cc(=O)n(CC(=O)Nc2ccc(C)c(Cl)c2)c(-n2nc(C)cc2C)n1,2.9547800000000013
194624,Optimize the molecule Cc1nn(C)c(Oc2cccc(-n3ccnc3)c2)c1[N+](=O)[O-] to have a higher LogP value.,Cc1nn(C)c(Oc2cccc(-n3ccnc3)c2)c1[N+](=O)[O-],2.614720000000001
7194,Please optimize the molecule CCCNC(=O)NCC(=O)N1CCC(Cc2ccccc2)CC1 to have a lower LogP value.,CCCNC(=O)NCC(=O)N1CCC(Cc2ccccc2)CC1,2.176899999999999
193400,Please optimize the molecule N#CCNC(=O)CN1C(=O)CCCc2cc(N)ccc21 to have a higher LogP value.,N#CCNC(=O)CN1C(=O)CCCc2cc(N)ccc21,0.5778799999999998
84068,Modify the molecule COc1ccc(OC)c(NC(=O)CSc2nc3sc(C)c(C)c3c(=O)[nH]2)c1 to increase its LogP value.,COc1ccc(OC)c(NC(=O)CSc2nc3sc(C)c(C)c3c(=O)[nH]2)c1,3.3494400000000013
232649,Please modify the molecule C=CCOc1ccc(C(=O)N2Cc3ccccc3C[C@H]2C(N)=O)cc1 to increase its LogP value.,C=CCOc1ccc(C(=O)N2Cc3ccccc3C[C@H]2C(N)=O)cc1,2.3038
75719,Please optimize the molecule COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1 to have a higher LogP value.,COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1,0.49300000000000105
239115,Modify the molecule CN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)C(=O)Cc1cccc(Cl)c1 to increase its LogP value.,CN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)C(=O)Cc1cccc(Cl)c1,0.6442000000000001
182797,Modify the molecule CCn1cc(/C=c2/sc3n(c2=O)[C@H](c2cccs2)C(C(=O)Nc2ccccc2)=C(C)N=3)cn1 to increase its LogP value.,CCn1cc(/C=c2/sc3n(c2=O)[C@H](c2cccs2)C(C(=O)Nc2ccccc2)=C(C)N=3)cn1,3.1518000000000015
146793,Optimize the molecule C[C@@H]1CCC[C@@H](C)N1C(=O)Cn1nc(-c2ccc(F)cc2)oc1=O to have a lower LogP value.,C[C@@H]1CCC[C@@H](C)N1C(=O)Cn1nc(-c2ccc(F)cc2)oc1=O,2.4319000000000006
215501,Modify the molecule CCc1ccc(OCC(=O)N/N=C/c2ccc(Br)s2)cc1 to have a lower LogP value.,CCc1ccc(OCC(=O)N/N=C/c2ccc(Br)s2)cc1,3.602100000000002
175574,Modify the molecule Nn1c([S-])nnc1CN1CCN(c2ccccc2)CC1 to increase its LogP value.,Nn1c([S-])nnc1CN1CCN(c2ccccc2)CC1,0.21989999999999976
201120,Optimize the molecule CS[C@H]1CCC[C@H]1[NH+](C)CC1(CO)COC1 to have a lower LogP value.,CS[C@H]1CCC[C@H]1[NH+](C)CC1(CO)COC1,-0.20589999999999842
47361,Please modify the molecule CCN(Cc1ccccn1)C(=O)NCc1ccc(C(C)(C)C)cc1 to increase its LogP value.,CCN(Cc1ccccn1)C(=O)NCc1ccc(C(C)(C)C)cc1,4.110800000000003
32926,Optimize the molecule Cc1cccc(CN2CCN(CC(=O)N3CCC(C)CC3)C(=O)C2=O)c1 to have a higher LogP value.,Cc1cccc(CN2CCN(CC(=O)N3CCC(C)CC3)C(=O)C2=O)c1,1.4243199999999998
179323,Please modify the molecule OC[C@@]1(CCc2ccccc2)CCC[NH+](Cc2cnc(N3CCOCC3)s2)C1 to decrease its LogP value.,OC[C@@]1(CCc2ccccc2)CCC[NH+](Cc2cnc(N3CCOCC3)s2)C1,1.7698999999999996
76920,Please modify the molecule O=C1CN(C(=O)c2cc3ccccc3[nH]c2=O)CCN1 to decrease its LogP value.,O=C1CN(C(=O)c2cc3ccccc3[nH]c2=O)CCN1,0.10010000000000013
70755,Modify the molecule COc1ccc2cc(/C([O-])=C(/C#N)C(=O)N3CCCC3)c(C)nc2c1 to have a lower LogP value.,COc1ccc2cc(/C([O-])=C(/C#N)C(=O)N3CCCC3)c(C)nc2c1,1.7691999999999999
18510,Optimize the molecule O=C(C[C@@H](O)c1ccccc1)NCc1ccc(-c2cccnc2)cc1 to have a lower LogP value.,O=C(C[C@@H](O)c1ccccc1)NCc1ccc(-c2cccnc2)cc1,3.488500000000002
18764,Optimize the molecule CCc1ccc(NS(=O)(=O)c2cc(-c3c(C)noc3C)ccc2C)cc1 to have a higher LogP value.,CCc1ccc(NS(=O)(=O)c2cc(-c3c(C)noc3C)ccc2C)cc1,4.630060000000004
62111,Please optimize the molecule CCN(C(=O)Nc1cc(NC(C)=O)c(F)cc1F)[C@H](C)c1cccc(OC)c1 to have a lower LogP value.,CCN(C(=O)Nc1cc(NC(C)=O)c(F)cc1F)[C@H](C)c1cccc(OC)c1,4.546800000000003
94313,Please modify the molecule O=C(CNC(=O)c1cccc(F)c1)OCC(=O)N1CCCc2ccccc21 to increase its LogP value.,O=C(CNC(=O)c1cccc(F)c1)OCC(=O)N1CCCc2ccccc21,2.0781
72997,Modify the molecule CCc1cccc(C(=O)N2CCN(Cc3ccncc3)CC2)c1O to increase its LogP value.,CCc1cccc(C(=O)N2CCN(Cc3ccncc3)CC2)c1O,2.3076000000000003
60299,Modify the molecule Cc1noc(Cl)c1CC(=O)N[C@H](C)Cc1c(Cl)cccc1Cl to increase its LogP value.,Cc1noc(Cl)c1CC(=O)N[C@H](C)Cc1c(Cl)cccc1Cl,4.233120000000002
10373,Please modify the molecule C[C@@H](NS(=O)(=O)c1cccc2cnccc12)c1ccccc1 to increase its LogP value.,C[C@@H](NS(=O)(=O)c1cccc2cnccc12)c1ccccc1,3.274300000000002
139490,Please modify the molecule CSc1ccc2c(c1)CCN(C(=O)c1c(C)cc(C)[nH]c1=O)C2 to increase its LogP value.,CSc1ccc2c(c1)CCN(C(=O)c1c(C)cc(C)[nH]c1=O)C2,2.912140000000001
15488,Optimize the molecule Fc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)c(F)c1F to have a lower LogP value.,Fc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)c(F)c1F,4.767700000000002
117619,Modify the molecule CCOC(=O)c1sc(NC(=O)CCC(=O)[O-])c(C#N)c1C to increase its LogP value.,CCOC(=O)c1sc(NC(=O)CCC(=O)[O-])c(C#N)c1C,0.5734999999999997
27411,Please modify the molecule CCn1cnnc1-c1cccc(NC(=O)[C@@H]2CC(=O)N(CC[NH+](C)C)C2)c1 to decrease its LogP value.,CCn1cnnc1-c1cccc(NC(=O)[C@@H]2CC(=O)N(CC[NH+](C)C)C2)c1,-0.10349999999999815
227566,Modify the molecule O=C(C[NH+]1CC[C@@H](O)C1)Nc1cc(F)ccc1F to have a lower LogP value.,O=C(C[NH+]1CC[C@@H](O)C1)Nc1cc(F)ccc1F,-0.44720000000000004
56388,Please modify the molecule C[C@H](NC(=O)[C@@H](C)Sc1ccccc1)c1ccc2c(c1)CCC(=O)N2 to decrease its LogP value.,C[C@H](NC(=O)[C@@H](C)Sc1ccccc1)c1ccc2c(c1)CCC(=O)N2,3.9293000000000022
14851,Please optimize the molecule Cc1ccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCN(C)CC4)cc3n2)cc1 to have a higher LogP value.,Cc1ccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCN(C)CC4)cc3n2)cc1,3.1111200000000014
97625,Modify the molecule C[C@H](Oc1ccc(Cl)cc1Br)C(=O)NNC(=O)c1cccc([N+](=O)[O-])c1 to decrease its LogP value.,C[C@H](Oc1ccc(Cl)cc1Br)C(=O)NNC(=O)c1cccc([N+](=O)[O-])c1,3.2392000000000003
51455,Optimize the molecule Cc1cccc(-n2nnnc2SCC(=O)N(C)[C@@H]2CCCc3ccccc32)c1 to have a higher LogP value.,Cc1cccc(-n2nnnc2SCC(=O)N(C)[C@@H]2CCCc3ccccc32)c1,3.5988200000000026
97056,Please optimize the molecule Cc1nn(C)c2ncc(NC(=O)N(C)[C@H](C)CS(C)(=O)=O)cc12 to have a higher LogP value.,Cc1nn(C)c2ncc(NC(=O)N(C)[C@H](C)CS(C)(=O)=O)cc12,1.17352
89674,Modify the molecule CC[NH2+]C[C@@H](CC1CCOCC1)c1cccc(Cl)c1 to decrease its LogP value.,CC[NH2+]C[C@@H](CC1CCOCC1)c1cccc(Cl)c1,2.8236000000000008
223537,Please modify the molecule C[C@H]([NH3+])[C@H](c1ccsc1)N1CCO[C@H](C#N)C1 to increase its LogP value.,C[C@H]([NH3+])[C@H](c1ccsc1)N1CCO[C@H](C#N)C1,0.6439799999999996
67394,Please modify the molecule NC(=O)c1ccc(NC(=O)NCc2ccc(F)cc2)c(F)c1 to decrease its LogP value.,NC(=O)c1ccc(NC(=O)NCc2ccc(F)cc2)c(F)c1,2.3853999999999997
35562,Please optimize the molecule Cc1n[nH]c(C)c1C[C@H](C)C(=O)N1CCCCC[C@H]1CC(C)C to have a lower LogP value.,Cc1n[nH]c(C)c1C[C@H](C)C(=O)N1CCCCC[C@H]1CC(C)C,4.022440000000003
135492,Modify the molecule COc1cc(Br)ccc1S(=O)(=O)NCc1cccnc1 to have a lower LogP value.,COc1cc(Br)ccc1S(=O)(=O)NCc1cccnc1,2.3312
176002,Modify the molecule CC(C)(C)c1ccc(C=C2C[NH2+]C2)cc1 to increase its LogP value.,CC(C)(C)c1ccc(C=C2C[NH2+]C2)cc1,1.9445000000000001
148467,Modify the molecule NS(=O)(=O)c1ccc(NC(=O)CSC2=NC(=O)C3=C4CCCC[C@H]4SC3=N2)cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(NC(=O)CSC2=NC(=O)C3=C4CCCC[C@H]4SC3=N2)cc1,2.2864000000000004
177584,Modify the molecule CN1C(=O)C(=Cc2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Br)c2)C(=O)N(C)C1=O to have a higher LogP value.,CN1C(=O)C(=Cc2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Br)c2)C(=O)N(C)C1=O,3.3701000000000025
25246,Please optimize the molecule CN(C(=O)c1ccc(-c2ccco2)[nH]c1=O)c1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,CN(C(=O)c1ccc(-c2ccco2)[nH]c1=O)c1ccc(Oc2ccccc2)cc1,4.703800000000004
194749,Modify the molecule CC[C@]1(C)C[C@@H]([C@H](Br)C(C)C)CCO1 to decrease its LogP value.,CC[C@]1(C)C[C@@H]([C@H](Br)C(C)C)CCO1,4.001200000000003
164063,Please modify the molecule O=C(N[C@@H]1CC[NH+]2CCCC[C@H]12)C(c1ccccc1)c1ccccc1 to decrease its LogP value.,O=C(N[C@@H]1CC[NH+]2CCCC[C@H]12)C(c1ccccc1)c1ccccc1,2.1444
45264,Modify the molecule Cc1cccc(-n2nnnc2SC[C@@H]2CNC(=O)O2)c1C to have a higher LogP value.,Cc1cccc(-n2nnnc2SC[C@@H]2CNC(=O)O2)c1C,1.47964
158895,Please modify the molecule O=C(Nc1ccc(-n2cccn2)cc1)c1nc[nH]n1 to increase its LogP value.,O=C(Nc1ccc(-n2cccn2)cc1)c1nc[nH]n1,1.2426999999999997
42910,Please modify the molecule C[C@H]1CCC[C@@]1(C[NH3+])Sc1ccccc1 to decrease its LogP value.,C[C@H]1CCC[C@@]1(C[NH3+])Sc1ccccc1,2.5794000000000006
226918,Optimize the molecule CCNC(=O)NNC(=O)CSc1cccc2cccc(Cl)c12 to have a higher LogP value.,CCNC(=O)NNC(=O)CSc1cccc2cccc(Cl)c12,2.9356000000000018
20387,Please modify the molecule Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+] to decrease its LogP value.,Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+],1.6504199999999996
69142,Please optimize the molecule CN(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCC#Cc1ccccc1 to have a higher LogP value.,CN(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCC#Cc1ccccc1,3.7783000000000024
183346,Modify the molecule CCCNC(=O)CN(C)C(=O)[C@@H]1CC[NH2+][C@H]1C to have a lower LogP value.,CCCNC(=O)CN(C)C(=O)[C@@H]1CC[NH2+][C@H]1C,-1.0571999999999966
155693,Please optimize the molecule COc1cccc(C(=O)Nc2sc(SC)nc2-c2ccccc2)c1OC to have a lower LogP value.,COc1cccc(C(=O)Nc2sc(SC)nc2-c2ccccc2)c1OC,4.801500000000003
133581,Please modify the molecule O=C1c2ccccc2S(=O)(=O)N1CNc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C1c2ccccc2S(=O)(=O)N1CNc1cccc(C(F)(F)F)c1,2.919500000000001
134667,Please modify the molecule CCn1c(N)c(C(=O)C[NH+]2CCC(C)CC2)c(=O)[nH]c1=O to decrease its LogP value.,CCn1c(N)c(C(=O)C[NH+]2CCC(C)CC2)c(=O)[nH]c1=O,-1.3637999999999977
54704,Modify the molecule CN(CCc1cccs1)[C@H](C[NH3+])c1cc(F)c(F)c(F)c1 to decrease its LogP value.,CN(CCc1cccs1)[C@H](C[NH3+])c1cc(F)c(F)c(F)c1,2.6229000000000005
173887,Optimize the molecule CCOC(=O)c1cccc(N[C@@H](C)[C@H]2CCCO2)n1 to have a higher LogP value.,CCOC(=O)c1cccc(N[C@@H](C)[C@H]2CCCO2)n1,2.2377000000000002
146576,Please modify the molecule ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1 to decrease its LogP value.,ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1,4.739400000000003
166433,Modify the molecule O=C1/C(=C\c2ccc(-c3ccc(Cl)cc3)o2)NC(=S)N1c1ccccc1 to have a higher LogP value.,O=C1/C(=C\c2ccc(-c3ccc(Cl)cc3)o2)NC(=S)N1c1ccccc1,4.862200000000003
215424,Please modify the molecule Cc1ccc2c(NC(=O)c3cc(-c4ccccc4Cl)no3)n[nH]c2n1 to decrease its LogP value.,Cc1ccc2c(NC(=O)c3cc(-c4ccccc4Cl)no3)n[nH]c2n1,3.827020000000001
203003,Modify the molecule CC[C@@H]([NH2+][C@H](c1ccccc1)C(C)C)c1nc(C)cs1 to increase its LogP value.,CC[C@@H]([NH2+][C@H](c1ccccc1)C(C)C)c1nc(C)cs1,3.8633200000000034
78125,Please modify the molecule CC(C)C[C@@H]1CNC(=[NH2+])N1c1ccccc1Cl to decrease its LogP value.,CC(C)C[C@@H]1CNC(=[NH2+])N1c1ccccc1Cl,1.2794000000000003
204648,Please modify the molecule CN(C)C(=O)C[NH+](C)CC(=O)NC1CCCCCCC1 to increase its LogP value.,CN(C)C(=O)C[NH+](C)CC(=O)NC1CCCCCCC1,-0.18159999999999754
221671,Please optimize the molecule CCOc1ccccc1C(=O)N[C@H](C(=O)N1CCCC[C@@H]1C)C(C)C to have a higher LogP value.,CCOc1ccccc1C(=O)N[C@H](C(=O)N1CCCC[C@@H]1C)C(C)C,3.240700000000002
64234,Modify the molecule O=C1[C@@H]2[C@H](C(=O)N1c1ccccc1F)C1c3ccccc3C2(Cl)c2ccccc21 to have a lower LogP value.,O=C1[C@@H]2[C@H](C(=O)N1c1ccccc1F)C1c3ccccc3C2(Cl)c2ccccc21,4.5728000000000035
115211,Modify the molecule NC(=S)N1N=C(c2ccccc2)C[C@H]1c1cccs1 to increase its LogP value.,NC(=S)N1N=C(c2ccccc2)C[C@H]1c1cccs1,3.142800000000002
81329,Optimize the molecule Cc1ccc(CCNC(=O)c2cc3sccc3n2CCc2ccccc2)o1 to have a higher LogP value.,Cc1ccc(CCNC(=O)c2cc3sccc3n2CCc2ccccc2)o1,4.819420000000004
215194,Please modify the molecule Cc1ccoc1[C@@H](C)[NH2+][C@H](C)c1cccc([N-]S(C)(=O)=O)c1 to increase its LogP value.,Cc1ccoc1[C@@H](C)[NH2+][C@H](C)c1cccc([N-]S(C)(=O)=O)c1,2.9384200000000016
121714,Please optimize the molecule C=CCN(C(=O)[C@H](C)S(C)(=O)=O)c1nc(-c2ccccc2)cs1 to have a higher LogP value.,C=CCN(C(=O)[C@H](C)S(C)(=O)=O)c1nc(-c2ccccc2)cs1,2.7622000000000018
98694,Modify the molecule CCc1n[nH]c(SCCCOc2ccc(C#N)cc2)n1 to have a lower LogP value.,CCc1n[nH]c(SCCCOc2ccc(C#N)cc2)n1,2.7999800000000015
212741,Modify the molecule Cc1ccc([C@H](N)CCN2CCOC(C)(C)C2)cc1F to have a lower LogP value.,Cc1ccc([C@H](N)CCN2CCOC(C)(C)C2)cc1F,2.6348200000000013
218200,Please optimize the molecule Cn1nc(NC(=O)c2ccc(C(F)(F)F)cc2)c2c1NC(=O)C[C@H]2c1ccco1 to have a higher LogP value.,Cn1nc(NC(=O)c2ccc(C(F)(F)F)cc2)c2c1NC(=O)C[C@H]2c1ccco1,3.758300000000001
133704,Please modify the molecule Cc1ccccc1N1CCN(C(=O)/C=C/c2cnn(C)c2)[C@H](C)C1 to increase its LogP value.,Cc1ccccc1N1CCN(C(=O)/C=C/c2cnn(C)c2)[C@H](C)C1,2.4790200000000002
124583,Optimize the molecule C[C@@H](CO)C[NH2+][C@@H]1CCOC2(CCOCC2)C1 to have a higher LogP value.,C[C@@H](CO)C[NH2+][C@@H]1CCOC2(CCOCC2)C1,-0.09359999999999924
70691,Optimize the molecule Cc1c([C@@H](C)NC(=O)c2ccc(NS(C)(=O)=O)cc2)cnn1C to have a higher LogP value.,Cc1c([C@@H](C)NC(=O)c2ccc(NS(C)(=O)=O)cc2)cnn1C,1.5910199999999999
98249,Modify the molecule CCOC(=O)c1ccccc1NC(=O)c1ccccc1 to decrease its LogP value.,CCOC(=O)c1ccccc1NC(=O)c1ccccc1,3.1156000000000015
169188,Optimize the molecule Cc1cc(C(=O)NCCCOc2ccccc2)no1 to have a higher LogP value.,Cc1cc(C(=O)NCCCOc2ccccc2)no1,2.18192
230769,Please optimize the molecule COc1cccc(-c2nnc(S[C@H]3CCCC[C@@H]3O)n2N)c1 to have a higher LogP value.,COc1cccc(-c2nnc(S[C@H]3CCCC[C@@H]3O)n2N)c1,2.0630999999999995
35244,Please modify the molecule CCc1c(C(=O)/C=C/c2ccc(NC(C)=O)cc2)oc2ccccc12 to decrease its LogP value.,CCc1c(C(=O)/C=C/c2ccc(NC(C)=O)cc2)oc2ccccc12,4.849700000000004
80764,Please optimize the molecule CCOc1ccccc1NC(=O)Cc1c(C)nc2nc(SC)nn2c1C to have a higher LogP value.,CCOc1ccccc1NC(=O)Cc1c(C)nc2nc(SC)nn2c1C,3.0429400000000015
101954,Please optimize the molecule Cc1cc(S(N)(=O)=O)cc(NC(=O)CSCc2ccccc2)c1C to have a higher LogP value.,Cc1cc(S(N)(=O)=O)cc(NC(=O)CSCc2ccccc2)c1C,2.8227400000000014
207418,Modify the molecule Nc1ccc2oc(NCc3ccsc3)nc2c1 to increase its LogP value.,Nc1ccc2oc(NCc3ccsc3)nc2c1,3.0836000000000006
32824,Please optimize the molecule Nc1cc(-c2cccs2)no1 to have a lower LogP value.,Nc1cc(-c2cccs2)no1,1.9852999999999998
2106,Modify the molecule COC(=O)Cn1cc(/C=C2/C(=O)N(c3cccc(F)c3)C(=O)N=C2[O-])c2ccccc21 to have a higher LogP value.,COC(=O)Cn1cc(/C=C2/C(=O)N(c3cccc(F)c3)C(=O)N=C2[O-])c2ccccc21,2.2624000000000004
60874,Please modify the molecule CN(C(=O)c1ccc(N2CCCC2)nc1)[C@@H]1CCc2ccccc2C1 to decrease its LogP value.,CN(C(=O)c1ccc(N2CCCC2)nc1)[C@@H]1CCc2ccccc2C1,3.311300000000002
23865,Optimize the molecule CSc1ccc(O[C@@H](C)C(=O)Nc2c(C)cnn2-c2ccccc2)cc1 to have a lower LogP value.,CSc1ccc(O[C@@H](C)C(=O)Nc2c(C)cnn2-c2ccccc2)cc1,4.308620000000003
9009,Please optimize the molecule CCOC(=O)C1=C(C)/C(=N\Nc2ccc(F)cc2)N=C1C to have a lower LogP value.,CCOC(=O)C1=C(C)/C(=N\Nc2ccc(F)cc2)N=C1C,2.9052000000000016
21467,Modify the molecule O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1 to have a lower LogP value.,O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1,1.7956999999999999
229891,Please modify the molecule CC[C@H](C)c1ccccc1OCC[NH+]1CCOCC1 to increase its LogP value.,CC[C@H](C)c1ccccc1OCC[NH+]1CCOCC1,1.4939999999999996
81386,Modify the molecule Cc1cncc(NC(=O)c2cc3cc(C)ccc3nc2C)c1 to have a higher LogP value.,Cc1cncc(NC(=O)c2cc3cc(C)ccc3nc2C)c1,3.807360000000002
149677,Modify the molecule Fc1cccc2c1OCC[C@H]2NCc1nncn1C1CC1 to have a higher LogP value.,Fc1cccc2c1OCC[C@H]2NCc1nncn1C1CC1,2.3655
134302,Modify the molecule CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21 to increase its LogP value.,CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21,3.424400000000001
36195,Modify the molecule CC(C)(C)C(=O)COC(=O)c1cc2ccccc2cc1O to have a lower LogP value.,CC(C)(C)C(=O)COC(=O)c1cc2ccccc2cc1O,3.3174000000000023
10361,Optimize the molecule c1ccc2c(c1)C[C@H](C[NH2+]C(C1CC1)C1CC1)S2 to have a lower LogP value.,c1ccc2c(c1)C[C@H](C[NH2+]C(C1CC1)C1CC1)S2,2.4554
170686,Please modify the molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-] to decrease its LogP value.,Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-],2.4058200000000003
192980,Please optimize the molecule Cc1ccc(NC(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2Cl)cc1 to have a higher LogP value.,Cc1ccc(NC(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2Cl)cc1,4.733520000000003
169024,Please modify the molecule CC(C)c1noc(CN2C(=O)[C@H](C)N(c3ccc(F)cc3)C2=O)n1 to decrease its LogP value.,CC(C)c1noc(CN2C(=O)[C@H](C)N(c3ccc(F)cc3)C2=O)n1,2.689400000000001
178775,Modify the molecule COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1 to increase its LogP value.,COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1,-0.4035999999999986
211923,Modify the molecule CCNC(=O)c1ccc(CNS(=O)(=O)c2ccccc2Cl)cc1 to have a higher LogP value.,CCNC(=O)c1ccc(CNS(=O)(=O)c2ccccc2Cl)cc1,2.568200000000001
138467,Please modify the molecule Cc1nn(C)c2sc(C(=O)Nc3ccc(OCC[NH+](C)C)cc3)cc12 to decrease its LogP value.,Cc1nn(C)c2sc(C(=O)Nc3ccc(OCC[NH+](C)C)cc3)cc12,1.7188199999999993
136023,Optimize the molecule COc1ccccc1Nc1nc2ccc(N)cc2[nH]1 to have a higher LogP value.,COc1ccccc1Nc1nc2ccc(N)cc2[nH]1,2.8972999999999995
129878,Please modify the molecule C[C@@H](NC(=O)c1cc2c(s1)CCC2)c1ccc(-n2cncn2)cc1 to increase its LogP value.,C[C@@H](NC(=O)c1cc2c(s1)CCC2)c1ccc(-n2cncn2)cc1,3.3085000000000013
109949,Please optimize the molecule Cc1c(F)cccc1NCc1cc(Cl)cc2c1OCOC2 to have a higher LogP value.,Cc1c(F)cccc1NCc1cc(Cl)cc2c1OCOC2,4.266120000000003
221070,Modify the molecule C[NH+](C)CCCNS(=O)(=O)Cc1ccc(Cl)c(Cl)c1 to have a lower LogP value.,C[NH+](C)CCCNS(=O)(=O)Cc1ccc(Cl)c(Cl)c1,0.9474000000000007
232555,Optimize the molecule CC(=O)NS(=O)(=O)c1ccc(NC(=O)C2CCN(c3ccccc3)CC2)cc1 to have a higher LogP value.,CC(=O)NS(=O)(=O)c1ccc(NC(=O)C2CCN(c3ccccc3)CC2)cc1,2.3665000000000003
40986,Optimize the molecule CN(C)S(=O)(=O)c1ccc(N2CCO[C@@H](C#N)C2)c(N)c1 to have a higher LogP value.,CN(C)S(=O)(=O)c1ccc(N2CCO[C@@H](C#N)C2)c(N)c1,0.24788000000000066
155281,Optimize the molecule O=C1[C@@H](c2ccsc2)N(c2ccc(Cl)cc2)C(=O)CN1c1ccccc1F to have a higher LogP value.,O=C1[C@@H](c2ccsc2)N(c2ccc(Cl)cc2)C(=O)CN1c1ccccc1F,4.661700000000003
86270,Optimize the molecule CC(C)CNC(=O)NC(=O)Cn1nnc2ccccc2c1=O to have a lower LogP value.,CC(C)CNC(=O)NC(=O)Cn1nnc2ccccc2c1=O,0.27329999999999927
112756,Please optimize the molecule Cc1cc(=O)n(CC(=O)Nc2cccc(C)c2C)c(-c2cccc(Cl)c2)n1 to have a higher LogP value.,Cc1cc(=O)n(CC(=O)Nc2cccc(C)c2C)c(-c2cccc(Cl)c2)n1,4.127660000000003
98232,Optimize the molecule CCCc1cc(OCC(=O)[O-])nc(Nc2ccc(C#N)cc2)n1 to have a lower LogP value.,CCCc1cc(OCC(=O)[O-])nc(Nc2ccc(C#N)cc2)n1,1.1730799999999997
118157,Optimize the molecule Cc1oc(C(=O)NCCn2cccc2)cc1S(=O)(=O)N(C)C to have a lower LogP value.,Cc1oc(C(=O)NCCn2cccc2)cc1S(=O)(=O)N(C)C,1.06982
245833,Please modify the molecule C[C@H](O)CN(C)C(=O)NCCCC[NH+]1CCCC1 to increase its LogP value.,C[C@H](O)CN(C)C(=O)NCCCC[NH+]1CCCC1,-0.5324999999999978
244880,Optimize the molecule CCOc1ccc(-n2c(C)c(C)c3c2ncn2nc(-c4ccccc4O)nc32)cc1 to have a higher LogP value.,CCOc1ccc(-n2c(C)c(C)c3c2ncn2nc(-c4ccccc4O)nc32)cc1,4.456340000000004
208738,Optimize the molecule Cc1cc([C@@H](C)NC(=O)NNC(=O)c2cccc(N(C)C)c2)c(C)s1 to have a lower LogP value.,Cc1cc([C@@H](C)NC(=O)NNC(=O)c2cccc(N(C)C)c2)c(C)s1,3.136140000000002
30212,Please modify the molecule C/C(=C\CC[NH3+])C[C@@H]1CCCO1 to increase its LogP value.,C/C(=C\CC[NH3+])C[C@@H]1CCCO1,1.1338
22277,Please optimize the molecule CC(C)NC(=O)c1ccc(NCC(=O)NCc2ccccc2F)cc1 to have a lower LogP value.,CC(C)NC(=O)c1ccc(NCC(=O)NCc2ccccc2F)cc1,2.6922000000000006
203863,Please modify the molecule CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1 to increase its LogP value.,CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1,0.6213000000000006
198195,Please optimize the molecule Cc1cc2c(cc1C)[C@@H](c1cc([N+](=O)[O-])ccc1Cl)CC(=O)N2 to have a lower LogP value.,Cc1cc2c(cc1C)[C@@H](c1cc([N+](=O)[O-])ccc1Cl)CC(=O)N2,4.339140000000003
240773,Modify the molecule Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12 to decrease its LogP value.,Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12,1.7324199999999996
173848,Please optimize the molecule C[C@H]1CCCCN1C(=O)NCc1ncnn1C to have a lower LogP value.,C[C@H]1CCCCN1C(=O)NCc1ncnn1C,0.8990999999999998
64315,Please optimize the molecule C[C@H]1CN(c2ccc(CNS(=O)(=O)Cc3ccccc3)c[nH+]2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CN(c2ccc(CNS(=O)(=O)Cc3ccccc3)c[nH+]2)C[C@H](C)O1,1.7339000000000002
28992,Modify the molecule CCOC(=O)c1ccc(/N=C2\NC(=O)S\C2=C/c2ccc(OC)cc2)cc1 to increase its LogP value.,CCOC(=O)c1ccc(/N=C2\NC(=O)S\C2=C/c2ccc(OC)cc2)cc1,4.399400000000003
78321,Optimize the molecule C[C@H](NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(N)=O)C1CCCCC1 to have a lower LogP value.,C[C@H](NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(N)=O)C1CCCCC1,1.4776999999999998
124608,Please modify the molecule COc1ccc(Cl)cc1C1(CNS(=O)(=O)c2cccs2)CCOCC1 to decrease its LogP value.,COc1ccc(Cl)cc1C1(CNS(=O)(=O)c2cccs2)CCOCC1,3.4368000000000025
132266,Modify the molecule CSCC[C@@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1nc2ccccc2[nH]1 to decrease its LogP value.,CSCC[C@@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1nc2ccccc2[nH]1,4.602700000000003
19166,Optimize the molecule COc1ccc2c(c1)[C@H](N)[C@H]([NH+](C)CC(C)(C)C)CC2 to have a lower LogP value.,COc1ccc2c(c1)[C@H](N)[C@H]([NH+](C)CC(C)(C)C)CC2,1.5705999999999998
56736,Please optimize the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)NNC(=O)Cn1ccc2ccccc21 to have a lower LogP value.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)NNC(=O)Cn1ccc2ccccc21,2.909600000000001
153684,Please modify the molecule CC(C)c1nnc(SCC(=O)Nc2nncs2)o1 to decrease its LogP value.,CC(C)c1nnc(SCC(=O)Nc2nncs2)o1,1.7752999999999999
11288,Please modify the molecule N#Cc1ccc(OC(=O)c2ccccc2SCC(N)=O)c(Cl)c1 to increase its LogP value.,N#Cc1ccc(OC(=O)c2ccccc2SCC(N)=O)c(Cl)c1,3.008280000000001
147628,Optimize the molecule C[NH2+][C@H](Cc1nc([C@@H]2CSCCS2)no1)C(C)(C)C to have a higher LogP value.,C[NH2+][C@H](Cc1nc([C@@H]2CSCCS2)no1)C(C)(C)C,1.7411000000000003
213699,Please optimize the molecule CCC(CC)[NH+](CC(C)C)[C@@H]1CCC[C@@H]1C[NH3+] to have a higher LogP value.,CCC(CC)[NH+](CC(C)C)[C@@H]1CCC[C@@H]1C[NH3+],1.126500000000002
126939,Please optimize the molecule C[NH2+]C[C@@H](Cc1ccccc1OC)c1cccc(F)c1 to have a lower LogP value.,C[NH2+]C[C@@H](Cc1ccccc1OC)c1cccc(F)c1,2.3538000000000006
147526,Modify the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1 to have a higher LogP value.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1,-0.4404999999999968
26153,Modify the molecule Cc1ccc(CC(=O)Nc2ccccc2Sc2nc(Br)nn2C)cc1 to have a higher LogP value.,Cc1ccc(CC(=O)Nc2ccccc2Sc2nc(Br)nn2C)cc1,4.218420000000003
87353,Optimize the molecule CCc1cccc(C)c1NC(=O)[C@H](C)O/N=C(/N)Cc1ccccc1C to have a higher LogP value.,CCc1cccc(C)c1NC(=O)[C@H](C)O/N=C(/N)Cc1ccccc1C,3.7243400000000015
170648,Optimize the molecule CNC(=O)[C@H]1CCC[NH+]1Cc1cc(Br)c(OC)s1 to have a higher LogP value.,CNC(=O)[C@H]1CCC[NH+]1Cc1cc(Br)c(OC)s1,0.8124999999999996
244720,Please optimize the molecule N/C(=N\OCCCCC(F)(F)F)C(F)(F)F to have a lower LogP value.,N/C(=N\OCCCCC(F)(F)F)C(F)(F)F,2.570100000000001
70638,Please optimize the molecule CCn1nc(C)c(CNC(=O)C(=O)Nc2ccc3cc[nH]c3c2)c1C to have a lower LogP value.,CCn1nc(C)c(CNC(=O)C(=O)Nc2ccc3cc[nH]c3c2)c1C,2.2560399999999996
109916,Please modify the molecule C[C@H](CC(=O)[O-])NC(=O)[C@@H]1Cc2ccccc2O1 to increase its LogP value.,C[C@H](CC(=O)[O-])NC(=O)[C@@H]1Cc2ccccc2O1,-0.36519999999999886
179459,Please modify the molecule COc1ccc([C@H](C)[NH2+]C[C@@]2(C)CCCO2)c(O)c1 to increase its LogP value.,COc1ccc([C@H](C)[NH2+]C[C@@]2(C)CCCO2)c(O)c1,1.5942999999999998
239946,Modify the molecule O=C([O-])/C=C/c1cc(F)cc(CSc2ccncc2)c1 to increase its LogP value.,O=C([O-])/C=C/c1cc(F)cc(CSc2ccncc2)c1,2.2761000000000005
163551,Please optimize the molecule Cc1ccc(NC(=O)[C@@H]2CC(=O)N(c3cccc(Cl)c3C)C2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)[C@@H]2CC(=O)N(c3cccc(Cl)c3C)C2)cc1,3.9484400000000024
23036,Please optimize the molecule O=S(=O)(/N=C(\[O-])[C@H]1C[C@@H]1c1ccc(C(F)(F)F)cc1)c1cccs1 to have a lower LogP value.,O=S(=O)(/N=C(\[O-])[C@H]1C[C@@H]1c1ccc(C(F)(F)F)cc1)c1cccs1,3.0181000000000013
53501,Please modify the molecule CC[NH+](CC)Cc1nc(-c2ccc(C(F)(F)F)cc2)no1 to increase its LogP value.,CC[NH+](CC)Cc1nc(-c2ccc(C(F)(F)F)cc2)no1,2.1801000000000004
7694,Modify the molecule COc1ccc(C(=O)NNC(=O)c2ccc(Cn3nnc(-c4ccccc4)n3)cc2)cc1 to have a lower LogP value.,COc1ccc(C(=O)NNC(=O)c2ccc(Cn3nnc(-c4ccccc4)n3)cc2)cc1,2.4718
139918,Please modify the molecule Cc1cnc2c(c1)nc(CCCl)n2-c1ccc(F)c(C)c1 to increase its LogP value.,Cc1cnc2c(c1)nc(CCCl)n2-c1ccc(F)c(C)c1,3.957740000000003
18627,Modify the molecule Cc1ccc(CNC(=O)[C@H](C)C2CCN(C(=O)[C@H]3C=c4cc(Cl)ccc4=[NH+]3)CC2)cc1 to have a lower LogP value.,Cc1ccc(CNC(=O)[C@H](C)C2CCN(C(=O)[C@H]3C=c4cc(Cl)ccc4=[NH+]3)CC2)cc1,0.7024200000000018
61847,Please optimize the molecule Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1 to have a lower LogP value.,Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1,3.2914400000000024
109803,Please modify the molecule COc1cccc(NC2CCN(C(=O)c3cccc([N+](=O)[O-])c3)CC2)c1 to increase its LogP value.,COc1cccc(NC2CCN(C(=O)c3cccc([N+](=O)[O-])c3)CC2)c1,3.320100000000002
46484,Modify the molecule Cc1c(C(=O)NCc2cc(C#N)ccc2F)oc2ccc(Cl)cc12 to increase its LogP value.,Cc1c(C(=O)NCc2cc(C#N)ccc2F)oc2ccc(Cl)cc12,4.335400000000002
240825,Optimize the molecule C[NH2+][C@@H](CC(C)C)[C@@H]1CCc2cccnc21 to have a lower LogP value.,C[NH2+][C@@H](CC(C)C)[C@@H]1CCc2cccnc21,1.7192999999999994
200614,Modify the molecule CCCCN(C)C(=O)C1CC[NH+](C2CCC(C)CC2)CC1 to decrease its LogP value.,CCCCN(C)C(=O)C1CC[NH+](C2CCC(C)CC2)CC1,2.1185
53268,Modify the molecule Nc1cc(C(=O)OCCF)ccc1Cl to decrease its LogP value.,Nc1cc(C(=O)OCCF)ccc1Cl,2.0484999999999998
143741,Please modify the molecule Cc1cc([C@@H](O)[C@]2(C[NH3+])CCc3ccccc3C2)c(C)s1 to increase its LogP value.,Cc1cc([C@@H](O)[C@]2(C[NH3+])CCc3ccccc3C2)c(C)s1,2.8155400000000013
229294,Optimize the molecule C[C@@H](NC(=O)c1ccccc1Cn1cccn1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,C[C@@H](NC(=O)c1ccccc1Cn1cccn1)c1cccc(C(F)(F)F)c1,4.441200000000004
99671,Please modify the molecule CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O to decrease its LogP value.,CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O,0.9159000000000013
180774,Please modify the molecule COC(=O)c1cc(CNC(=O)C[C@H](C)c2ccccc2)oc1C to decrease its LogP value.,COC(=O)c1cc(CNC(=O)C[C@H](C)c2ccccc2)oc1C,3.1846200000000016
221959,Modify the molecule Cc1ccc(CNC(=O)[C@@H]2CCCN(c3nc4ccccc4[nH]c3=O)C2)o1 to have a higher LogP value.,Cc1ccc(CNC(=O)[C@@H]2CCCN(c3nc4ccccc4[nH]c3=O)C2)o1,2.3573200000000005
177204,Please modify the molecule CC(C)C(=O)NC[C@H]1CCCN(C(=O)N[C@H](C)c2ccc(Cl)s2)C1 to increase its LogP value.,CC(C)C(=O)NC[C@H]1CCCN(C(=O)N[C@H](C)c2ccc(Cl)s2)C1,3.6563000000000017
98860,Modify the molecule Oc1ccc(Cl)cc1CN(CC(F)F)C1CC1 to have a lower LogP value.,Oc1ccc(Cl)cc1CN(CC(F)F)C1CC1,3.275100000000002
147728,Please optimize the molecule O=S(=O)(c1ccc(F)cc1)N1CCCN(Cc2cc(-c3ccco3)on2)CC1 to have a higher LogP value.,O=S(=O)(c1ccc(F)cc1)N1CCCN(Cc2cc(-c3ccco3)on2)CC1,2.9703000000000017
148589,Modify the molecule C=CC[C@@H]1C(C)=NN(C(=O)c2ccc(C)cc2)[C@]1(C)O to have a lower LogP value.,C=CC[C@@H]1C(C)=NN(C(=O)c2ccc(C)cc2)[C@]1(C)O,2.7275200000000015
55283,Modify the molecule Cc1ccc(C2=NCC(=O)N(CC(=O)N3CCCCC3)c3sc4c(c32)CCC4)cc1 to increase its LogP value.,Cc1ccc(C2=NCC(=O)N(CC(=O)N3CCCCC3)c3sc4c(c32)CCC4)cc1,3.7417200000000026
188681,Modify the molecule CC(C)[C@H](NC(=O)[C@@H](C)Oc1ccccc1Cl)c1ccccn1 to decrease its LogP value.,CC(C)[C@H](NC(=O)[C@@H](C)Oc1ccccc1Cl)c1ccccn1,4.015800000000002
216803,Please optimize the molecule Cc1ccc(C(=O)N2CCN(c3ccc(NC(=O)CSc4nnc(C)o4)cc3)CC2)cc1 to have a higher LogP value.,Cc1ccc(C(=O)N2CCN(c3ccc(NC(=O)CSc4nnc(C)o4)cc3)CC2)cc1,3.379640000000002
141670,Modify the molecule O=C(/C(=C\C=C\c1ccccc1)c1nc2ccccc2o1)c1cccnc1 to increase its LogP value.,O=C(/C(=C\C=C\c1ccccc1)c1nc2ccccc2o1)c1cccnc1,5.202500000000004
241873,Optimize the molecule COc1ccc([C@@H]2[C@@H](C(=O)Nc3ccc4[nH]ccc4c3)c3ccccc3C(=O)N2C)cc1 to have a higher LogP value.,COc1ccc([C@@H]2[C@@H](C(=O)Nc3ccc4[nH]ccc4c3)c3ccccc3C(=O)N2C)cc1,4.7257000000000025
120174,Modify the molecule COc1ccccc1OCC(=O)Nc1ccc(Br)c(Cl)c1 to have a higher LogP value.,COc1ccccc1OCC(=O)Nc1ccc(Br)c(Cl)c1,4.128600000000003
164241,Please modify the molecule C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCC(C(=O)N(C)C)CC1 to decrease its LogP value.,C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCC(C(=O)N(C)C)CC1,0.8640000000000008
83956,Please modify the molecule COc1ccc([C@@H]2c3c(oc4ccccc4c3=O)C(=O)N2c2cc(C)on2)cc1OC to decrease its LogP value.,COc1ccc([C@@H]2c3c(oc4ccccc4c3=O)C(=O)N2c2cc(C)on2)cc1OC,3.8564200000000026
152649,Modify the molecule Brc1ccc(-c2nnc(COc3ccccc3Br)o2)cc1 to have a lower LogP value.,Brc1ccc(-c2nnc(COc3ccccc3Br)o2)cc1,4.840600000000002
191770,Modify the molecule COCC(=O)Nc1cccc(C(=O)Nc2cccc(OC)c2)c1 to decrease its LogP value.,COCC(=O)Nc1cccc(C(=O)Nc2cccc(OC)c2)c1,2.532400000000001
139280,Please optimize the molecule COc1ccc([C@@H](O)[C@H]2CCCN2C(=O)CCc2nc(-c3ccsc3)no2)cc1 to have a lower LogP value.,COc1ccc([C@@H](O)[C@H]2CCCN2C(=O)CCc2nc(-c3ccsc3)no2)cc1,3.4639000000000024
8009,Modify the molecule COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12 to decrease its LogP value.,COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12,2.5678
248709,Modify the molecule C[NH2+][C@H](Cc1ccccn1)c1cc(C(F)(F)F)ccc1F to increase its LogP value.,C[NH2+][C@H](Cc1ccccn1)c1cc(C(F)(F)F)ccc1F,2.716500000000001
21632,Modify the molecule O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2 to increase its LogP value.,O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2,3.9064000000000014
171809,Modify the molecule Cc1cc(C)cc(NC(=O)CS[C@@H](C)[C@H](C)O)c1 to increase its LogP value.,Cc1cc(C)cc(NC(=O)CS[C@@H](C)[C@H](C)O)c1,2.744440000000001
201965,Please modify the molecule C=C(C)CN(CC)C(=O)[C@H](C)[n+]1ccc(Cc2ccccc2)cc1 to increase its LogP value.,C=C(C)CN(CC)C(=O)[C@H](C)[n+]1ccc(Cc2ccccc2)cc1,3.550500000000002
165417,Optimize the molecule Cc1ccc(C)c(OC2CCN(C[C@H](O)CN3CCOCC3)CC2)c1 to have a higher LogP value.,Cc1ccc(C)c(OC2CCN(C[C@H](O)CN3CCOCC3)CC2)c1,1.83974
245940,Please optimize the molecule CCCCC[C@H](C)[NH2+][C@H]1CC[C@H]([NH+](C)C)C1 to have a lower LogP value.,CCCCC[C@H](C)[NH2+][C@H]1CC[C@H]([NH+](C)C)C1,0.5842000000000027
61199,Please optimize the molecule C[C@@H](NC(=O)c1cnc([C@@H]2CCCO2)s1)c1ccc(-n2ccnc2)cc1 to have a lower LogP value.,C[C@@H](NC(=O)c1cnc([C@@H]2CCCO2)s1)c1ccc(-n2ccnc2)cc1,3.671300000000003
114102,Optimize the molecule CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1 to have a lower LogP value.,CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1,2.1005
93592,Modify the molecule CCOC(=O)c1c(NC(=O)c2cc3cccc(OC)c3oc2=O)sc(C)c1C to decrease its LogP value.,CCOC(=O)c1c(NC(=O)c2cc3cccc(OC)c3oc2=O)sc(C)c1C,3.908940000000003
217129,Optimize the molecule CCCCc1ccc(CC(=O)NC2(C(N)=O)CCCCC2)cc1 to have a higher LogP value.,CCCCc1ccc(CC(=O)NC2(C(N)=O)CCCCC2)cc1,2.876100000000001
11171,Modify the molecule Cc1ccccc1C(=O)NCCNC(=O)c1nc(Cn2nc(C)c(Cl)c2C)no1 to increase its LogP value.,Cc1ccccc1C(=O)NCCNC(=O)c1nc(Cn2nc(C)c(Cl)c2C)no1,2.05286
144843,Please optimize the molecule COc1cc(OC)c(C(=O)N(C)CCC(C)C)cc1OC to have a higher LogP value.,COc1cc(OC)c(C(=O)N(C)CCC(C)C)cc1OC,2.8305000000000007
148864,Modify the molecule CN(CC[NH+]1CCCC1)[C@@H](C(=O)Nc1ccccc1)c1ccccc1 to have a higher LogP value.,CN(CC[NH+]1CCCC1)[C@@H](C(=O)Nc1ccccc1)c1ccccc1,1.9769000000000003
201642,Modify the molecule O=C(Nc1nc2c(s1)CCCC2)c1cc(F)ccc1Br to decrease its LogP value.,O=C(Nc1nc2c(s1)CCCC2)c1cc(F)ccc1Br,4.175800000000002
167339,Please modify the molecule Cc1cccnc1NC(=O)c1ccc(/C=C2\SC(=O)NC2=O)cc1 to increase its LogP value.,Cc1cccnc1NC(=O)c1ccc(/C=C2\SC(=O)NC2=O)cc1,2.9662200000000007
183421,Please optimize the molecule C[C@H](NC(=O)N1CC[C@@H](Nc2ccccc2)C1)c1ccc2c(c1)OCCO2 to have a lower LogP value.,C[C@H](NC(=O)N1CC[C@@H](Nc2ccccc2)C1)c1ccc2c(c1)OCCO2,3.4148000000000023
184014,Please modify the molecule CC(C)[C@H](C)N1C[C@H]2CCCC[NH+]2C[C@@H]1C to decrease its LogP value.,CC(C)[C@H](C)N1C[C@H]2CCCC[NH+]2C[C@@H]1C,1.1724000000000003
166818,Please modify the molecule N#Cc1ccsc1NC(=O)CCCOc1ccc(Cl)cc1Cl to decrease its LogP value.,N#Cc1ccsc1NC(=O)CCCOc1ccc(Cl)cc1Cl,4.724280000000002
162806,Modify the molecule O=C(NC[C@H]1Cc2cccc(F)c2O1)c1c(F)cccc1F to have a higher LogP value.,O=C(NC[C@H]1Cc2cccc(F)c2O1)c1c(F)cccc1F,2.8374000000000006
102114,Optimize the molecule Cc1noc(C)c1C(=O)N1CCC2(CCC(=O)N(CCCn3cc[nH+]c3)C2)CC1 to have a higher LogP value.,Cc1noc(C)c1C(=O)N1CCC2(CCC(=O)N(CCCn3cc[nH+]c3)C2)CC1,1.8421399999999999
116490,Modify the molecule COC(C)(C)CNC(=O)N[C@@H]1CCO[C@H]1c1ccc(Cl)c(F)c1 to have a lower LogP value.,COC(C)(C)CNC(=O)N[C@@H]1CCO[C@H]1c1ccc(Cl)c(F)c1,3.0333000000000014
183034,Please optimize the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1 to have a lower LogP value.,COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1,4.126000000000004
177160,Modify the molecule Cc1n[nH]c(-c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)n3)cc2)n1 to decrease its LogP value.,Cc1n[nH]c(-c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)n3)cc2)n1,2.7522200000000003
170125,Modify the molecule Cc1ncsc1CN(C)[C@H](C[NH3+])CC(=O)N(C)C to have a lower LogP value.,Cc1ncsc1CN(C)[C@H](C[NH3+])CC(=O)N(C)C,-0.027879999999998573
218560,Please modify the molecule COc1cccc(CN(C[C@H]2CC(c3ccccc3)=NO2)C(=O)NC(C)C)c1 to increase its LogP value.,COc1cccc(CN(C[C@H]2CC(c3ccccc3)=NO2)C(=O)NC(C)C)c1,3.8084000000000024
99209,Modify the molecule O=C(NCCCn1nc2n(c1=O)CCCC2)Nc1ccc(N2CCCS2(=O)=O)cc1 to have a higher LogP value.,O=C(NCCCn1nc2n(c1=O)CCCC2)Nc1ccc(N2CCCS2(=O)=O)cc1,1.1327999999999991
101718,Please optimize the molecule Cc1cc(C)n(-c2ccc(NC(=O)[C@@H]3CCCCN3C(=O)C(=O)c3ccccc3)cc2)n1 to have a lower LogP value.,Cc1cc(C)n(-c2ccc(NC(=O)[C@@H]3CCCCN3C(=O)C(=O)c3ccccc3)cc2)n1,3.691640000000003
47778,Optimize the molecule COc1cc(C)ccc1NC(=O)[C@@H]1CC(=O)N(C(C)C)C1 to have a lower LogP value.,COc1cc(C)ccc1NC(=O)[C@@H]1CC(=O)N(C(C)C)C1,2.19902
88301,Please optimize the molecule c1ccc2c(c1)CCSC[C@@H]2[NH2+]C[C@@H]1C[NH+]2CCN1CC2 to have a higher LogP value.,c1ccc2c(c1)CCSC[C@@H]2[NH2+]C[C@@H]1C[NH+]2CCN1CC2,-0.8368999999999964
30150,Please optimize the molecule CCC(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1 to have a lower LogP value.,CCC(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1,1.7011999999999996
113565,Please modify the molecule C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1 to decrease its LogP value.,C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1,2.2430000000000003
215145,Modify the molecule CCOc1ccc2[nH]c(=O)c([C@H](c3nnnn3C(C)(C)C)N3CCc4ccccc4C3)cc2c1 to have a higher LogP value.,CCOc1ccc2[nH]c(=O)c([C@H](c3nnnn3C(C)(C)C)N3CCc4ccccc4C3)cc2c1,3.8160000000000025
136433,Optimize the molecule C=CCNC(=O)CSc1nnc2cc(C)c3ccc(OC)cc3n12 to have a lower LogP value.,C=CCNC(=O)CSc1nnc2cc(C)c3ccc(OC)cc3n12,2.593820000000001
242928,Modify the molecule Cc1[nH]c2ccc(C(=O)N[C@@H]3CC[C@H]([NH+](C)C)C3)cc2c1C to increase its LogP value.,Cc1[nH]c2ccc(C(=O)N[C@@H]3CC[C@H]([NH+](C)C)C3)cc2c1C,1.5801399999999999
196182,Modify the molecule C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1 to decrease its LogP value.,C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1,2.1887999999999996
164899,Modify the molecule Cc1cc2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)ccc2[nH]1 to have a lower LogP value.,Cc1cc2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)ccc2[nH]1,3.1908200000000013
212830,Optimize the molecule Cn1cc(C[C@@H](C[NH3+])c2cccc(F)c2)cn1 to have a lower LogP value.,Cn1cc(C[C@@H](C[NH3+])c2cccc(F)c2)cn1,1.1274000000000002
120822,Modify the molecule CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCN(C2CC2)C[C@@H]1Cc1ccccc1 to have a higher LogP value.,CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCN(C2CC2)C[C@@H]1Cc1ccccc1,4.415300000000004
127498,Please modify the molecule CC[C@H](Cc1ccc(C)cc1)NC(=O)NNC(=O)c1cc(C)oc1C to decrease its LogP value.,CC[C@H](Cc1ccc(C)cc1)NC(=O)NNC(=O)c1cc(C)oc1C,3.170160000000002
18043,Modify the molecule Cc1cc(NC(=O)c2cc3c([nH]c2=O)CCCC3)ccc1C(N)=O to have a higher LogP value.,Cc1cc(NC(=O)c2cc3c([nH]c2=O)CCCC3)ccc1C(N)=O,1.91332
208972,Modify the molecule O=C(Nc1ccc(Br)cc1F)[C@H]1C[C@H]2CC[C@@H]1O2 to increase its LogP value.,O=C(Nc1ccc(Br)cc1F)[C@H]1C[C@H]2CC[C@@H]1O2,3.0942000000000016
1523,Please modify the molecule CC(C)(C)c1nc(CNC(=O)N[C@H]2CCCC2(C)C)no1 to increase its LogP value.,CC(C)(C)c1nc(CNC(=O)N[C@H]2CCCC2(C)C)no1,2.745000000000001
148464,Please optimize the molecule COc1cc(-c2noc(-c3cnn(-c4ccccc4)c3)n2)ccn1 to have a higher LogP value.,COc1cc(-c2noc(-c3cnn(-c4ccccc4)c3)n2)ccn1,2.9929000000000006
114876,Modify the molecule CC[C@H](C)[NH+]1CCN(c2nc(Br)cn3ccnc23)CC1 to increase its LogP value.,CC[C@H](C)[NH+]1CCN(c2nc(Br)cn3ccnc23)CC1,0.9951999999999996
159090,Optimize the molecule O=C(CNc1ccc(C(F)(F)F)cn1)N1CCCC1 to have a lower LogP value.,O=C(CNc1ccc(C(F)(F)F)cn1)N1CCCC1,2.1346999999999996
131805,Modify the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)c2ccc(OCC(N)=O)cc2)C1 to decrease its LogP value.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)c2ccc(OCC(N)=O)cc2)C1,-0.6538999999999966
238682,Please modify the molecule CC(=O)N1CCN(Cc2cccc(NC(=O)c3ccc(C)c(C)c3)n2)CC1 to increase its LogP value.,CC(=O)N1CCN(Cc2cccc(NC(=O)c3ccc(C)c(C)c3)n2)CC1,2.614840000000001
134670,Please optimize the molecule COc1ccc([C@H]2CC(c3ccccc3)=NN2C(=O)Cn2cnc3ccccc32)cc1 to have a higher LogP value.,COc1ccc([C@H]2CC(c3ccccc3)=NN2C(=O)Cn2cnc3ccccc32)cc1,4.422800000000004
1379,Please optimize the molecule C=C(Br)CN1CCN(c2cc(C)[nH+]c(C)n2)CC1 to have a lower LogP value.,C=C(Br)CN1CCN(c2cc(C)[nH+]c(C)n2)CC1,1.54314
78205,Modify the molecule Cc1ccc(CCC(=O)N[C@@H]2CCCC[C@H]2C)o1 to decrease its LogP value.,Cc1ccc(CCC(=O)N[C@@H]2CCCC[C@H]2C)o1,3.2155200000000015
23830,Modify the molecule COc1ccc(OC)c(S(=O)(=O)NCC#CCOc2ccc(C)nc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)NCC#CCOc2ccc(C)nc2)c1,1.76792
161689,Please modify the molecule Cc1noc(C)c1CC(=O)Nc1ccc2c(C)n[nH]c2c1 to decrease its LogP value.,Cc1noc(C)c1CC(=O)Nc1ccc2c(C)n[nH]c2c1,2.6573600000000006
170277,Modify the molecule O=C(CCS(=O)(=O)c1ccccc1)NCC#CCOc1ccccc1F to decrease its LogP value.,O=C(CCS(=O)(=O)c1ccccc1)NCC#CCOc1ccccc1F,2.1881000000000004
103967,Please optimize the molecule O=c1c(NCc2ccccc2Cl)c(-c2ccccc2)c1=O to have a higher LogP value.,O=c1c(NCc2ccccc2Cl)c(-c2ccccc2)c1=O,3.2151000000000014
235714,Modify the molecule CC(C)[C@@H](C[NH3+])[C@H](O)CC12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,CC(C)[C@@H](C[NH3+])[C@H](O)CC12CC3CC(CC(C3)C1)C2,2.4679
210324,Modify the molecule CC(=O)N(c1cccc(Cl)c1)c1nc(CN2CCC[C@H]2[C@@H]2CCC[NH+]2C)cs1 to have a higher LogP value.,CC(=O)N(c1cccc(Cl)c1)c1nc(CN2CCC[C@H]2[C@@H]2CCC[NH+]2C)cs1,3.1226000000000003
164896,Modify the molecule O=C(C[C@H]1S/C(=N/c2cccc3ccccc23)NC1=O)Nc1cccc(C(F)(F)F)c1 to have a higher LogP value.,O=C(C[C@H]1S/C(=N/c2cccc3ccccc23)NC1=O)Nc1cccc(C(F)(F)F)c1,5.106500000000002
176125,Modify the molecule CCCOc1ccc2cc(C(=O)Nc3ccc(C)c(C)c3)c(=O)oc2c1 to increase its LogP value.,CCCOc1ccc2cc(C(=O)Nc3ccc(C)c(C)c3)c(=O)oc2c1,4.450940000000004
241298,Please optimize the molecule CC1(C)CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)[C@@H]1[NH3+] to have a higher LogP value.,CC1(C)CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)[C@@H]1[NH3+],-1.240899999999994
459,Please optimize the molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 to have a lower LogP value.,Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1,4.071620000000003
47196,Modify the molecule Cc1ccc(C(=O)Nc2cc(Cl)c3nc(NN)sc3c2Cl)cc1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2cc(Cl)c3nc(NN)sc3c2Cl)cc1,4.449420000000002
35193,Optimize the molecule Cc1ccc(NNC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)nc1 to have a higher LogP value.,Cc1ccc(NNC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)nc1,1.7227199999999996
7555,Optimize the molecule C[NH2+][C@H]1CC[C@@H](N2CCC([NH+](C)C)CC2)C1 to have a higher LogP value.,C[NH2+][C@H]1CC[C@@H](N2CCC([NH+](C)C)CC2)C1,-1.290399999999996
1623,Please modify the molecule O=C(Nc1ccc2c(c1)OCCO2)c1cc2cc([N+](=O)[O-])ccc2s1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)OCCO2)c1cc2cc([N+](=O)[O-])ccc2s1,3.833000000000002
220916,Please optimize the molecule N#CCOc1cccc(CC(=O)N2CC[C@@H](O)C2)c1 to have a higher LogP value.,N#CCOc1cccc(CC(=O)N2CC[C@@H](O)C2)c1,0.7246800000000002
233282,Please modify the molecule COCCOc1cc(C)ccc1NC(=O)C(=O)N[C@H]1CCC[C@@H](C)[C@@H]1C to increase its LogP value.,COCCOc1cc(C)ccc1NC(=O)C(=O)N[C@H]1CCC[C@@H](C)[C@@H]1C,2.8996200000000005
210430,Modify the molecule Cc1cccnc1C[C@H](Cl)c1cc(F)ccc1F to increase its LogP value.,Cc1cccnc1C[C@H](Cl)c1cc(F)ccc1F,4.190820000000003
241441,Modify the molecule CC(C)[NH+](C)C[C@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(F)c1 to increase its LogP value.,CC(C)[NH+](C)C[C@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(F)c1,2.6046000000000014
136905,Optimize the molecule CC[C@H]1c2ccsc2CCN1C(=O)CNc1c(F)cccc1F to have a lower LogP value.,CC[C@H]1c2ccsc2CCN1C(=O)CNc1c(F)cccc1F,3.9742000000000033
41679,Modify the molecule O=Cc1ccc(OCCC(=O)N[C@H]2CCc3cc(Cl)ccc32)cc1 to have a higher LogP value.,O=Cc1ccc(OCCC(=O)N[C@H]2CCc3cc(Cl)ccc32)cc1,3.725100000000002
231391,Modify the molecule COc1cccc(NC(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1C to increase its LogP value.,COc1cccc(NC(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1C,3.255740000000002
183577,Modify the molecule c1ccc(Cc2noc(CCc3cnccn3)n2)cc1 to decrease its LogP value.,c1ccc(Cc2noc(CCc3cnccn3)n2)cc1,2.2356
93210,Modify the molecule CCn1nc(C)c([N+](=O)[O-])c1NCc1c(C)noc1C to have a higher LogP value.,CCn1nc(C)c([N+](=O)[O-])c1NCc1c(C)noc1C,2.3365600000000004
226437,Modify the molecule COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCNC(=O)CC1 to have a lower LogP value.,COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCNC(=O)CC1,1.8536999999999997
23864,Please modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)/C=C/c2cccc(OC)c2)C1 to decrease its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)/C=C/c2cccc(OC)c2)C1,1.2485999999999993
63489,Modify the molecule CCc1cccc(NC(=O)[C@H](C)Sc2nnc(-n3nc(C)cc3C)n2N)c1 to decrease its LogP value.,CCc1cccc(NC(=O)[C@H](C)Sc2nnc(-n3nc(C)cc3C)n2N)c1,2.47614
139627,Modify the molecule Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C to decrease its LogP value.,Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C,4.003840000000003
215144,Modify the molecule Cc1ccc(NC(=O)CN2C(=O)S/C(=C/c3c(C)n(C)c4ccccc34)C2=O)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)CN2C(=O)S/C(=C/c3c(C)n(C)c4ccccc34)C2=O)cc1,4.470140000000003
186986,Optimize the molecule Cc1cc(C[NH+]2CCC3(CC2)C[C@@H]3c2nnc(-c3ccccc3)o2)on1 to have a lower LogP value.,Cc1cc(C[NH+]2CCC3(CC2)C[C@@H]3c2nnc(-c3ccccc3)o2)on1,2.3856200000000003
18692,Modify the molecule Cc1ccccc1N1CCN(Cc2cc(=O)n3ccsc3[nH+]2)CC1 to increase its LogP value.,Cc1ccccc1N1CCN(Cc2cc(=O)n3ccsc3[nH+]2)CC1,1.80572
154105,Optimize the molecule CC(C)([C@H](N)c1ccccc1Cl)[NH+]1CCCCCC1 to have a lower LogP value.,CC(C)([C@H](N)c1ccccc1Cl)[NH+]1CCCCCC1,2.577300000000001
113378,Modify the molecule Cc1ccccc1[C@@H]1CCCN1CN1C(=O)C[C@]2(CCSC2)C1=O to increase its LogP value.,Cc1ccccc1[C@@H]1CCCN1CN1C(=O)C[C@]2(CCSC2)C1=O,2.9716200000000015
176603,Please optimize the molecule O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)C1 to have a higher LogP value.,O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)C1,3.5375000000000014
40877,Please optimize the molecule C[C@@H](CCc1ccccc1)NC(=O)C(=O)NCc1ccccc1Cl to have a higher LogP value.,C[C@@H](CCc1ccccc1)NC(=O)C(=O)NCc1ccccc1Cl,3.093700000000001
164010,Modify the molecule CC(C)c1ccc(N/N=C2/C(=O)NC(=O)N=C2[O-])cc1 to decrease its LogP value.,CC(C)c1ccc(N/N=C2/C(=O)NC(=O)N=C2[O-])cc1,0.5864999999999999
223763,Modify the molecule Cc1cccc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)c1 to decrease its LogP value.,Cc1cccc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)c1,0.7708199999999998
155254,Please optimize the molecule CCn1ncc(NC(=O)[C@H](C)n2cc3c(n2)c(C)nn3C)c1C to have a lower LogP value.,CCn1ncc(NC(=O)[C@H](C)n2cc3c(n2)c(C)nn3C)c1C,1.8027399999999998
15103,Modify the molecule CC[C@H](C)NC(=O)c1c([O-])n(-c2ccc(OC)cc2)c2ncccc2c1=O to have a lower LogP value.,CC[C@H](C)NC(=O)c1c([O-])n(-c2ccc(OC)cc2)c2ncccc2c1=O,1.9961999999999998
106687,Optimize the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)C[C@H]3CCCO3)C2)c1 to have a higher LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)C[C@H]3CCCO3)C2)c1,1.7924
111692,Please optimize the molecule COC1(OC)CCOC[C@H]1O to have a higher LogP value.,COC1(OC)CCOC[C@H]1O,-0.24330000000000024
64386,Modify the molecule CC(C)[NH2+][C@@]1(CO)CC[C@@H](Sc2ccc(C(C)C)cc2)C1 to have a lower LogP value.,CC(C)[NH2+][C@@]1(CO)CC[C@@H](Sc2ccc(C(C)C)cc2)C1,3.1575000000000015
58067,Modify the molecule C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C/C(=N/OCC(=O)N[C@@H](CO)C(=O)[O-])CC[C@]4(C)[C@H]3CC[C@@]21C to decrease its LogP value.,C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C/C(=N/OCC(=O)N[C@@H](CO)C(=O)[O-])CC[C@]4(C)[C@H]3CC[C@@]21C,1.2997999999999998
135763,Optimize the molecule COc1ccc(N2C[C@H](c3nnc(NC(=O)c4ccc(Cl)cc4)o3)CC2=O)cc1 to have a lower LogP value.,COc1ccc(N2C[C@H](c3nnc(NC(=O)c4ccc(Cl)cc4)o3)CC2=O)cc1,3.504400000000002
217785,Modify the molecule NC1=[NH+]C[C@@]2(CCC[C@H](C3CC3)C2)N1c1ccc(Cl)cc1 to decrease its LogP value.,NC1=[NH+]C[C@@]2(CCC[C@H](C3CC3)C2)N1c1ccc(Cl)cc1,1.8942999999999992
105444,Optimize the molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)c(C)c1 to have a lower LogP value.,CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)c(C)c1,3.423420000000002
211293,Modify the molecule C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1 to increase its LogP value.,C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1,-0.039899999999998936
246630,Optimize the molecule OCC[C@H](Nc1ccc2nnc(-c3ccccc3)n2n1)c1cccs1 to have a higher LogP value.,OCC[C@H](Nc1ccc2nnc(-c3ccccc3)n2n1)c1cccs1,3.3884000000000016
14498,Please modify the molecule C=CCN(Cc1ccc(C#N)cc1)[C@H]1CCN(CC(F)(F)F)C1=O to increase its LogP value.,C=CCN(Cc1ccc(C#N)cc1)[C@H]1CCN(CC(F)(F)F)C1=O,2.709480000000001
8742,Please modify the molecule C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(N)cc1Br to increase its LogP value.,C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(N)cc1Br,1.6771999999999996
213768,Please modify the molecule Cn1c(N2CCC(NC(=O)Nc3ccccc3)CC2)[nH+]c2ccccc21 to increase its LogP value.,Cn1c(N2CCC(NC(=O)Nc3ccccc3)CC2)[nH+]c2ccccc21,2.7829000000000006
248982,Modify the molecule O=C(Nc1ccc(I)cc1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1Cl to increase its LogP value.,O=C(Nc1ccc(I)cc1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1Cl,4.013300000000002
196672,Modify the molecule OCC1([NH+]2CCCC2)CC[NH2+]CC1 to decrease its LogP value.,OCC1([NH+]2CCCC2)CC[NH2+]CC1,-2.2465999999999964
199739,Please optimize the molecule CCN(c1ccccc1)S(=O)(=O)c1ccc(NC2CCN(C(=O)C3CC3)CC2)nc1 to have a lower LogP value.,CCN(c1ccccc1)S(=O)(=O)c1ccc(NC2CCN(C(=O)C3CC3)CC2)nc1,3.109700000000002
194217,Modify the molecule CCc1nn(C)c2c1[nH]c(=S)n2CCCOC to decrease its LogP value.,CCc1nn(C)c2c1[nH]c(=S)n2CCCOC,2.0312900000000003
108872,Please optimize the molecule OC[C@@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@H]1O to have a higher LogP value.,OC[C@@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@H]1O,-3.2214000000000005
226817,Please modify the molecule CCC[NH+]1CCC(NC(=O)NC2(CC(=O)[O-])CCC2)CC1 to increase its LogP value.,CCC[NH+]1CCC(NC(=O)NC2(CC(=O)[O-])CCC2)CC1,-1.194399999999997
146668,Modify the molecule COc1ccc2c(c1)C=C(C(=O)N1CCc3[nH]ncc3C1)CO2 to decrease its LogP value.,COc1ccc2c(c1)C=C(C(=O)N1CCc3[nH]ncc3C1)CO2,1.779
42942,Modify the molecule Cc1nc2cc(C(=O)[O-])ccc2n1CCCN1CCOCC1 to have a higher LogP value.,Cc1nc2cc(C(=O)[O-])ccc2n1CCCN1CCOCC1,0.43052
36015,Modify the molecule CC(=O)c1ccc(NC(=O)c2cccc(NC(=O)N3CCSc4ncccc43)c2)cc1 to have a higher LogP value.,CC(=O)c1ccc(NC(=O)c2cccc(NC(=O)N3CCSc4ncccc43)c2)cc1,4.680700000000003
11959,Please optimize the molecule Cn1cccc1CNc1cnn(CC(=O)N2CCOCC2)c1 to have a higher LogP value.,Cn1cccc1CNc1cnn(CC(=O)N2CCOCC2)c1,0.6924999999999997
59294,Modify the molecule CC(C)[C@@H](c1nnnn1Cc1ccc(F)cc1)N1CCN(c2ccccc2F)CC1 to increase its LogP value.,CC(C)[C@@H](c1nnnn1Cc1ccc(F)cc1)N1CCN(c2ccccc2F)CC1,3.518900000000002
97581,Please optimize the molecule CCN(C(=O)CSc1nnnn1-c1ccccc1C)[C@H]1CCS(=O)(=O)C1 to have a lower LogP value.,CCN(C(=O)CSc1nnnn1-c1ccccc1C)[C@H]1CCS(=O)(=O)C1,1.09842
209937,Modify the molecule O=C(CSc1ccccc1Br)c1c[nH]c2ccccc12 to have a lower LogP value.,O=C(CSc1ccccc1Br)c1c[nH]c2ccccc12,4.905400000000003
193497,Modify the molecule Cn1cccc1CN1CCc2c(Br)cccc2C1 to increase its LogP value.,Cn1cccc1CN1CCc2c(Br)cccc2C1,3.345900000000002
78144,Modify the molecule CCC(CC)C(=O)NNC(=O)c1ccc(Br)s1 to increase its LogP value.,CCC(CC)C(=O)NNC(=O)c1ccc(Br)s1,2.7077999999999998
186396,Modify the molecule COc1ccc(NC(=O)[C@@H]2[C@@H]3NC(=S)N[C@@]2(C)Oc2ccccc23)cc1 to decrease its LogP value.,COc1ccc(NC(=O)[C@@H]2[C@@H]3NC(=S)N[C@@]2(C)Oc2ccccc23)cc1,2.5775000000000006
90260,Please modify the molecule COc1ccc(CNC(=O)NC[C@@H](O)c2ccco2)cc1OC to increase its LogP value.,COc1ccc(CNC(=O)NC[C@@H](O)c2ccco2)cc1OC,1.8296000000000001
68676,Please modify the molecule CCCCN(CC)[C@H](C[NH3+])c1cc(Cl)cs1 to decrease its LogP value.,CCCCN(CC)[C@H](C[NH3+])c1cc(Cl)cs1,2.8064999999999998
122885,Modify the molecule COC(=O)[C@@H]1CN(C(=O)c2cc(C(C)=O)c[nH]2)C[C@H]1C to have a higher LogP value.,COC(=O)[C@@H]1CN(C(=O)c2cc(C(C)=O)c[nH]2)C[C@H]1C,1.0984
34501,Please modify the molecule O=C([C@@H]1CC(=O)N(c2ccccc2Cl)C1)N1CCO[C@H](c2ccc(F)cc2)C1 to increase its LogP value.,O=C([C@@H]1CC(=O)N(c2ccccc2Cl)C1)N1CCO[C@H](c2ccc(F)cc2)C1,3.432100000000002
56665,Optimize the molecule CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O,2.0694999999999997
75651,Modify the molecule CO[C@@H]1CCCN(C(=O)N[C@@H](C)c2nc(C(C)(C)C)no2)C1 to increase its LogP value.,CO[C@@H]1CCCN(C(=O)N[C@@H](C)c2nc(C(C)(C)C)no2)C1,2.2485
168748,Optimize the molecule CC(C)(C)CC(=O)Nc1ccc(F)cc1F to have a lower LogP value.,CC(C)(C)CC(=O)Nc1ccc(F)cc1F,3.339500000000002
93983,Optimize the molecule C#CCN1C(=O)c2ccccc2N[C@H]1c1ccc(OC)c(OCC)c1 to have a lower LogP value.,C#CCN1C(=O)c2ccccc2N[C@H]1c1ccc(OC)c(OCC)c1,3.2936000000000023
175578,Modify the molecule O[C@H](C[C@@H]1CCCCC[NH+]1Cc1c[nH]nc1-c1cccnc1)c1ccccc1 to have a lower LogP value.,O[C@H](C[C@@H]1CCCCC[NH+]1Cc1c[nH]nc1-c1cccnc1)c1ccccc1,2.922900000000001
40546,Modify the molecule CNc1nc(Cc2ccc(OC)nc2)ns1 to have a lower LogP value.,CNc1nc(Cc2ccc(OC)nc2)ns1,1.5742
236962,Modify the molecule CCN(Cc1c(F)cccc1Cl)C(=O)CCc1c(C)nn(C)c1C to have a lower LogP value.,CCN(Cc1c(F)cccc1Cl)C(=O)CCc1c(C)nn(C)c1C,3.8107400000000027
116275,Optimize the molecule COc1ccc(CCn2cc(C(=O)[O-])c(=O)[nH]c2=O)cc1 to have a higher LogP value.,COc1ccc(CCn2cc(C(=O)[O-])c(=O)[nH]c2=O)cc1,-0.8485999999999994
16835,Optimize the molecule CC[C@H](C)[NH+](CC)CC(=O)N(C)c1ccc(N)cc1 to have a lower LogP value.,CC[C@H](C)[NH+](CC)CC(=O)N(C)c1ccc(N)cc1,0.9349000000000011
61804,Modify the molecule [NH3+][C@H](c1ncc[nH]1)[C@@H]1CCCc2cccnc21 to decrease its LogP value.,[NH3+][C@H](c1ncc[nH]1)[C@@H]1CCCc2cccnc21,1.2077999999999987
50516,Optimize the molecule O=C(C[C@@H]1C(=O)Nc2ncnn21)Nc1cccc(F)c1 to have a lower LogP value.,O=C(C[C@@H]1C(=O)Nc2ncnn21)Nc1cccc(F)c1,0.9391999999999995
141349,Modify the molecule O=C1CC[C@H](C(=O)N[C@H]2CCc3ccccc32)N1 to increase its LogP value.,O=C1CC[C@H](C(=O)N[C@H]2CCc3ccccc32)N1,1.0687000000000002
227915,Modify the molecule Cc1[nH]c2ccc(C(=O)N[C@H]3CC[C@@H]([NH+](C)C)C3)cc2c1C to have a lower LogP value.,Cc1[nH]c2ccc(C(=O)N[C@H]3CC[C@@H]([NH+](C)C)C3)cc2c1C,1.5801399999999999
155378,Modify the molecule CCCCCNC(=O)NC1CC[NH+](CC(N)=O)CC1 to increase its LogP value.,CCCCCNC(=O)NC1CC[NH+](CC(N)=O)CC1,-0.9915999999999958
132107,Modify the molecule O=C(C[NH+]1CC[C@](O)(C(F)(F)F)C1)NCc1ccc(Cl)cc1 to have a lower LogP value.,O=C(C[NH+]1CC[C@](O)(C(F)(F)F)C1)NCc1ccc(Cl)cc1,0.5382
83051,Optimize the molecule CCn1c(SCC(=O)Nc2ccnn2C2CCCC2)nc2cc(S(N)(=O)=O)ccc21 to have a higher LogP value.,CCn1c(SCC(=O)Nc2ccnn2C2CCCC2)nc2cc(S(N)(=O)=O)ccc21,2.7460000000000004
184803,Modify the molecule Clc1cc(N2CCC[C@H](OCc3cccnc3)C2)nc2[nH]ccc12 to decrease its LogP value.,Clc1cc(N2CCC[C@H](OCc3cccnc3)C2)nc2[nH]ccc12,3.7969000000000017
68334,Please optimize the molecule COc1cc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)nc(SC)n1 to have a higher LogP value.,COc1cc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)nc(SC)n1,2.652700000000001
102388,Modify the molecule C[C@H](CCCO)NC(=O)N(Cc1ccccc1)C1CC1 to have a lower LogP value.,C[C@H](CCCO)NC(=O)N(Cc1ccccc1)C1CC1,2.521600000000001
2646,Please modify the molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 to decrease its LogP value.,CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1,2.4616000000000007
155141,Optimize the molecule C[C@H]1CN(C[C@@H]2CCC[NH+]2CC(=O)NC[C@@H]2CCCO2)C[C@H](C)O1 to have a higher LogP value.,C[C@H]1CN(C[C@@H]2CCC[NH+]2CC(=O)NC[C@@H]2CCCO2)C[C@H](C)O1,-0.5618999999999952
57338,Modify the molecule CCOC(=O)C1=C(Cc2ccc(OC)cc2)C(=O)c2ccccc2C1=O to have a higher LogP value.,CCOC(=O)C1=C(Cc2ccc(OC)cc2)C(=O)c2ccccc2C1=O,3.1766000000000023
192257,Modify the molecule O=S(=O)([C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1)N1CCCC1 to have a higher LogP value.,O=S(=O)([C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1)N1CCCC1,2.479
33404,Please modify the molecule CCOC(=O)c1sc(NC(=O)/C=C/c2cnn(C)c2)c(C#N)c1C to decrease its LogP value.,CCOC(=O)c1sc(NC(=O)/C=C/c2cnn(C)c2)c(C#N)c1C,2.4903000000000004
247981,Optimize the molecule C[C@H](C(N)=O)N1C[C@@H](c2ccc(Cl)cc2)CC1=O to have a higher LogP value.,C[C@H](C(N)=O)N1C[C@@H](c2ccc(Cl)cc2)CC1=O,1.5297000000000003
54903,Modify the molecule COc1ccnc(NC(=O)c2cc3c([nH]c2=O)CCCC3)c1 to decrease its LogP value.,COc1ccnc(NC(=O)c2cc3c([nH]c2=O)CCCC3)c1,1.9095999999999997
22644,Optimize the molecule CC(C)(C)N1CCN(C(=O)CCCC(=O)[O-])CC1 to have a lower LogP value.,CC(C)(C)N1CCN(C(=O)CCCC(=O)[O-])CC1,-0.15069999999999872
159133,Modify the molecule CCC[NH2+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1 to have a lower LogP value.,CCC[NH2+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1,-1.1454999999999946
51055,Please optimize the molecule COc1ccc([C@@H](C#N)NC(=O)c2ccc3cc[nH]c3c2)c(OC)c1 to have a lower LogP value.,COc1ccc([C@@H](C#N)NC(=O)c2ccc3cc[nH]c3c2)c(OC)c1,3.179780000000001
18606,Modify the molecule O=C(NC[C@@H]1CN2CCCC[C@H]2CO1)N1CCC(CN2CCOCC2)CC1 to increase its LogP value.,O=C(NC[C@@H]1CN2CCCC[C@H]2CO1)N1CCC(CN2CCOCC2)CC1,0.9935000000000007
87740,Please optimize the molecule O=C(c1n[nH]c([O-])n1)N1CCC[C@H]1C[C@H](O)c1ccccc1 to have a higher LogP value.,O=C(c1n[nH]c([O-])n1)N1CCC[C@H]1C[C@H](O)c1ccccc1,0.6065999999999994
84409,Modify the molecule COc1cc(Cl)ccc1C(=O)Nc1cnn(C(C)C)c1 to have a higher LogP value.,COc1cc(Cl)ccc1C(=O)Nc1cnn(C(C)C)c1,3.378300000000001
12319,Modify the molecule C[NH+](C)[C@@H](CNC(=O)c1ccccc1C(F)(F)F)c1ccc(F)cc1 to increase its LogP value.,C[NH+](C)[C@@H](CNC(=O)c1ccccc1C(F)(F)F)c1ccc(F)cc1,2.4601000000000015
18024,Please optimize the molecule Cc1cccc(S(N)(=O)=O)c1[N+](=O)[O-] to have a higher LogP value.,Cc1cccc(S(N)(=O)=O)c1[N+](=O)[O-],0.5506200000000001
69670,Optimize the molecule Cc1ccc(-c2cc(C(=O)N(C)Cc3ccnc4ccccc34)[nH]n2)s1 to have a higher LogP value.,Cc1ccc(-c2cc(C(=O)N(C)Cc3ccnc4ccccc34)[nH]n2)s1,4.267020000000003
159752,Please optimize the molecule CC(C)Oc1cccnc1C(=O)Nc1cccc(Oc2cnccn2)c1 to have a higher LogP value.,CC(C)Oc1cccnc1C(=O)Nc1cccc(Oc2cnccn2)c1,3.703400000000002
85763,Modify the molecule CC[C@](C)([NH3+])C(=O)N1CC[C@H](COC)C1 to increase its LogP value.,CC[C@](C)([NH3+])C(=O)N1CC[C@H](COC)C1,-0.10809999999999942
38826,Modify the molecule CCn1c(C)cc(C(=O)N(C)CC(=O)Nc2c(C)cccc2C)c1C to have a higher LogP value.,CCn1c(C)cc(C(=O)N(C)CC(=O)Nc2c(C)cccc2C)c1C,3.4523800000000024
94406,Optimize the molecule C[NH+](Cc1csc(Br)c1)C[C@H]1CCC(C)(C)[C@H]1O to have a lower LogP value.,C[NH+](Cc1csc(Br)c1)C[C@H]1CCC(C)(C)[C@H]1O,2.3224000000000014
125440,Modify the molecule Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1 to have a lower LogP value.,Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1,0.8642200000000001
116179,Please optimize the molecule Cc1csc(Sc2ccc(NC(=O)c3cccnc3Cl)cc2)n1 to have a higher LogP value.,Cc1csc(Sc2ccc(NC(=O)c3cccnc3Cl)cc2)n1,4.903420000000002
83040,Modify the molecule O=C(N[C@@H]1c2ccccc2C[C@H]1O)c1cccc(OCC(F)F)n1 to have a higher LogP value.,O=C(N[C@@H]1c2ccccc2C[C@H]1O)c1cccc(OCC(F)F)n1,2.1136
65865,Please modify the molecule CCOC(=O)Cn1c([C@H](C)Br)nc2ccccc2c1=O to decrease its LogP value.,CCOC(=O)Cn1c([C@H](C)Br)nc2ccccc2c1=O,2.4155000000000006
241919,Optimize the molecule CC(C)CC(=O)C1=C([O-])C(=O)N(CC[NH3+])[C@H]1c1ccc(F)cc1 to have a higher LogP value.,CC(C)CC(=O)C1=C([O-])C(=O)N(CC[NH3+])[C@H]1c1ccc(F)cc1,0.18050000000000105
37559,Please optimize the molecule Cc1cc(C[C@@H](C)N[C@@H](C)c2ccncc2)n(-c2ccccc2)n1 to have a higher LogP value.,Cc1cc(C[C@@H](C)N[C@@H](C)c2ccncc2)n(-c2ccccc2)n1,3.8575200000000027
56679,Optimize the molecule CCn1nc(C)c([C@H](C)[NH2+]C[C@H]2CCCN(c3ncccn3)C2)c1C to have a lower LogP value.,CCn1nc(C)c([C@H](C)[NH2+]C[C@H]2CCCN(c3ncccn3)C2)c1C,1.8508399999999998
62574,Modify the molecule COc1cccc(-c2nnc3sc(-c4cc(OC)c(OC)c(OC)c4)nn23)c1 to increase its LogP value.,COc1cccc(-c2nnc3sc(-c4cc(OC)c(OC)c(OC)c4)nn23)c1,3.5542000000000025
62581,Please optimize the molecule COc1ccc(-c2cc(CNC(=O)c3ccc([N+](=O)[O-])o3)no2)cc1 to have a higher LogP value.,COc1ccc(-c2cc(CNC(=O)c3ccc([N+](=O)[O-])o3)no2)cc1,2.7814000000000005
137849,Modify the molecule COc1cc(C[C@@H](C)[C@@H](C)[C@H](O)c2ccc(O)c(OC)c2)ccc1O to have a lower LogP value.,COc1cc(C[C@@H](C)[C@@H](C)[C@H](O)c2ccc(O)c(OC)c2)ccc1O,3.6633000000000027
47081,Optimize the molecule CCN[C@@]1(C(=O)OC)CC[C@H](Sc2n[nH]c(=O)n2C)C1 to have a higher LogP value.,CCN[C@@]1(C(=O)OC)CC[C@H](Sc2n[nH]c(=O)n2C)C1,0.2742999999999994
175639,Modify the molecule Cn1c(SCCOc2cccc(Br)c2)nnc1[C@H]1CCS(=O)(=O)C1 to have a higher LogP value.,Cn1c(SCCOc2cccc(Br)c2)nnc1[C@H]1CCS(=O)(=O)C1,2.6508000000000003
141829,Please modify the molecule COCCCOc1nc(C(F)(F)F)ccc1C[NH3+] to decrease its LogP value.,COCCCOc1nc(C(F)(F)F)ccc1C[NH3+],1.2576000000000003
184948,Please optimize the molecule O=C1CN(C(=O)C[C@H]2CCCCO2)CCN1 to have a higher LogP value.,O=C1CN(C(=O)C[C@H]2CCCCO2)CCN1,-0.09599999999999959
164219,Modify the molecule CC(C)c1n[nH]c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)n1 to increase its LogP value.,CC(C)c1n[nH]c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)n1,1.5732
71964,Modify the molecule Cc1ccc(N(Cc2ccco2)C(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)cc1 to have a lower LogP value.,Cc1ccc(N(Cc2ccco2)C(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)cc1,3.9933200000000033
70134,Modify the molecule C[NH+](C)CCO/N=C(/C=C\c1ccc(O)cc1)c1ccccc1F to increase its LogP value.,C[NH+](C)CCO/N=C(/C=C\c1ccc(O)cc1)c1ccccc1F,2.109900000000001
154524,Please optimize the molecule CN(CCc1cccs1)C(=O)NCC1(c2ccc(F)cc2F)CC1 to have a higher LogP value.,CN(CCc1cccs1)C(=O)NCC1(c2ccc(F)cc2F)CC1,3.942000000000003
117897,Modify the molecule OCC[NH+](Cc1cccnc1)[C@@H]1CCC[C@H](C2CC2)C1 to decrease its LogP value.,OCC[NH+](Cc1cccnc1)[C@@H]1CCC[C@H](C2CC2)C1,1.4275999999999998
4158,Modify the molecule COc1ccc(C)cc1N[C@@H](C)C(=O)NC1CCCCC1 to have a higher LogP value.,COc1ccc(C)cc1N[C@@H](C)C(=O)NC1CCCCC1,3.2529200000000023
92928,Please modify the molecule C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N(C)C1CCOCC1 to decrease its LogP value.,C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N(C)C1CCOCC1,2.7398000000000016
123104,Modify the molecule O=C(CCn1cncn1)N(Cc1ccccc1)Cc1ccco1 to have a higher LogP value.,O=C(CCn1cncn1)N(Cc1ccccc1)Cc1ccco1,2.4902000000000006
162591,Please modify the molecule CCOC(=O)c1c(/N=C/c2cc(I)ccc2O)sc2c1CC[NH+](C)C2 to increase its LogP value.,CCOC(=O)c1c(/N=C/c2cc(I)ccc2O)sc2c1CC[NH+](C)C2,2.556400000000001
20717,Optimize the molecule COc1cc(OC)cc(C(=O)N2CCN(c3ccc(N4CCCC4)nn3)CC2)c1 to have a lower LogP value.,COc1cc(OC)cc(C(=O)N2CCN(c3ccc(N4CCCC4)nn3)CC2)c1,2.0564
64569,Please modify the molecule CCc1ccc(NC(=O)[C@@H](C)Sc2nc(C)c(C)n2CC(C)C)cc1 to increase its LogP value.,CCc1ccc(NC(=O)[C@@H](C)Sc2nc(C)c(C)n2CC(C)C)cc1,4.837640000000004
180517,Please optimize the molecule COc1ccc(C(=O)N2CCC([C@H](NC(=O)c3ccc(F)cc3)C(=O)N3CCOCC3)CC2)cc1 to have a lower LogP value.,COc1ccc(C(=O)N2CCC([C@H](NC(=O)c3ccc(F)cc3)C(=O)N3CCOCC3)CC2)cc1,2.3439000000000005
103481,Optimize the molecule C[C@H](Cc1ccc(O)cc1)NC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 to have a higher LogP value.,C[C@H](Cc1ccc(O)cc1)NC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,0.6880000000000004
11070,Please modify the molecule CCc1cc(C[NH+](C)C)c(O)c(C[NH+](C)C)c1 to decrease its LogP value.,CCc1cc(C[NH+](C)C)c(O)c(C[NH+](C)C)c1,-0.7563999999999977
246409,Optimize the molecule CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1 to have a higher LogP value.,CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1,3.4380400000000018
215250,Modify the molecule CCN([C@H](C)c1cc2ccccc2o1)S(=O)(=O)c1ccc(Cl)nc1 to have a lower LogP value.,CCN([C@H](C)c1cc2ccccc2o1)S(=O)(=O)c1ccc(Cl)nc1,4.253000000000004
157604,Modify the molecule CCC[NH+](C)C[C@@H]1CCN(C(=O)NCc2cc[nH+]c(N3CCCC3)c2)C1 to decrease its LogP value.,CCC[NH+](C)C[C@@H]1CCN(C(=O)NCc2cc[nH+]c(N3CCCC3)c2)C1,0.5571000000000024
158944,Modify the molecule CC(=O)N1CCCc2cc(S(=O)(=O)N(C)Cc3cccc(Cl)c3)ccc21 to increase its LogP value.,CC(=O)N1CCCc2cc(S(=O)(=O)N(C)Cc3cccc(Cl)c3)ccc21,3.459800000000002
206775,Optimize the molecule C[NH+]1CCC(N[C@@H]2COc3cc(O)ccc32)CC1 to have a higher LogP value.,C[NH+]1CCC(N[C@@H]2COc3cc(O)ccc32)CC1,0.09240000000000093
38739,Optimize the molecule Cc1ccc(NC(=O)CN2N=N[C@H]3C(=O)N(c4ccc(Cl)cc4)C(=O)[C@H]32)c(Cl)c1 to have a lower LogP value.,Cc1ccc(NC(=O)CN2N=N[C@H]3C(=O)N(c4ccc(Cl)cc4)C(=O)[C@H]32)c(Cl)c1,3.2337200000000017
50136,Modify the molecule C[C@H](c1c(F)cccc1F)S(=O)(=O)CCOC1CCCCCC1 to have a lower LogP value.,C[C@H](c1c(F)cccc1F)S(=O)(=O)CCOC1CCCCCC1,4.180000000000004
195676,Please modify the molecule N#Cc1cc(N2C[C@H]3CC=CC[C@@H]3C2)nc2ccccc12 to decrease its LogP value.,N#Cc1cc(N2C[C@H]3CC=CC[C@@H]3C2)nc2ccccc12,3.508880000000002
9121,Modify the molecule C[NH2+][C@@]1(CO)CC[C@H](OCC2CCCCC2)C1 to have a lower LogP value.,C[NH2+][C@@]1(CO)CC[C@H](OCC2CCCCC2)C1,1.0600999999999998
91793,Optimize the molecule COc1cc(NC(=O)c2ccc(-c3ccccc3[N+](=O)[O-])o2)ccc1NC(=O)C(C)C to have a lower LogP value.,COc1cc(NC(=O)c2ccc(-c3ccccc3[N+](=O)[O-])o2)ccc1NC(=O)C(C)C,4.710200000000003
9449,Modify the molecule CC[C@@H](NC(=O)Cn1c(CS(C)(=O)=O)nc2ccccc21)c1cccc(Cl)c1 to increase its LogP value.,CC[C@@H](NC(=O)Cn1c(CS(C)(=O)=O)nc2ccccc21)c1cccc(Cl)c1,3.501800000000002
62424,Modify the molecule CC[NH2+]C[C@@H]1CCO[C@@H]1c1cn2ccccc2n1 to increase its LogP value.,CC[NH2+]C[C@@H]1CCO[C@@H]1c1cn2ccccc2n1,0.9951999999999996
6116,Modify the molecule Cc1cc(=O)c(C(=O)NO[C@@H]2CCCCO2)nn1-c1ccccc1 to decrease its LogP value.,Cc1cc(=O)c(C(=O)NO[C@@H]2CCCCO2)nn1-c1ccccc1,1.7289199999999991
47283,Optimize the molecule COc1cccc([C@@H]2c3c(nc(N4CCCC[C@@H]4C)[nH]c3=O)NC(=O)[C@@H]2C#N)c1OC to have a higher LogP value.,COc1cccc([C@@H]2c3c(nc(N4CCCC[C@@H]4C)[nH]c3=O)NC(=O)[C@@H]2C#N)c1OC,2.3896799999999994
54227,Modify the molecule Cc1ccc([C@@H](C)CNC(=O)N(C)Cc2nnc(C)n2C)cc1 to have a higher LogP value.,Cc1ccc([C@@H](C)CNC(=O)N(C)Cc2nnc(C)n2C)cc1,2.37704
231526,Optimize the molecule CCC[C@@H](C)[NH2+]Cc1coc(-c2ccc(C)cc2)n1 to have a higher LogP value.,CCC[C@@H](C)[NH2+]Cc1coc(-c2ccc(C)cc2)n1,2.902020000000001
22086,Modify the molecule CCOC(=O)c1sc(N/N=C/[C@H]2CC=CCC2)nc1C to have a higher LogP value.,CCOC(=O)c1sc(N/N=C/[C@H]2CC=CCC2)nc1C,3.382220000000002
204686,Modify the molecule CCc1c(N)nnn1CCN1CCOCC1 to increase its LogP value.,CCc1c(N)nnn1CCN1CCOCC1,-0.24509999999999899
189234,Please modify the molecule CCCn1cc(NS(=O)(=O)c2ccc(OC)c(OC)c2)ccc1=O to increase its LogP value.,CCCn1cc(NS(=O)(=O)c2ccc(OC)c(OC)c2)ccc1=O,2.0763
126089,Please modify the molecule O=S(=O)(c1ccc2ccccc2c1)N1CCCSC[C@@H]1CN1CCOCC1 to increase its LogP value.,O=S(=O)(c1ccc2ccccc2c1)N1CCCSC[C@@H]1CN1CCOCC1,2.6682000000000006
193842,Modify the molecule COc1c(CN[C@@H](c2ccc(C)cc2)c2cccs2)c(C)nn1C to increase its LogP value.,COc1c(CN[C@@H](c2ccc(C)cc2)c2cccs2)c(C)nn1C,3.986240000000003
186097,Please modify the molecule CC(C)(CNCC(F)F)S(C)(=O)=O to increase its LogP value.,CC(C)(CNCC(F)F)S(C)(=O)=O,0.6643000000000001
64285,Please optimize the molecule Cc1cc(C)c2nc3c(cc2c1)CN(Cc1cccnc1)/C(=[NH+]/C[C@@H]1CCCO1)S3 to have a lower LogP value.,Cc1cc(C)c2nc3c(cc2c1)CN(Cc1cccnc1)/C(=[NH+]/C[C@@H]1CCCO1)S3,2.9701400000000007
13429,Please optimize the molecule COc1ccc(CNC(=O)N[C@H]2CCCC[C@H]2CO)c(OC)c1 to have a higher LogP value.,COc1ccc(CNC(=O)N[C@H]2CCCC[C@H]2CO)c(OC)c1,2.0541
238257,Please modify the molecule C[C@H](NC(=O)Cc1ccc[nH]1)c1ccc(F)cc1F to increase its LogP value.,C[C@H](NC(=O)Cc1ccc[nH]1)c1ccc(F)cc1F,2.7128000000000005
127323,Modify the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)Nc1ccccc1[N+](=O)[O-] to have a higher LogP value.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)Nc1ccccc1[N+](=O)[O-],1.4277999999999997
221259,Modify the molecule CC(C)Cn1c(S[C@@H](C)C(=O)Nc2c(Cl)cc(Cl)cc2Cl)nnc1N1CCOCC1 to decrease its LogP value.,CC(C)Cn1c(S[C@@H](C)C(=O)Nc2c(Cl)cc(Cl)cc2Cl)nnc1N1CCOCC1,4.850200000000004
46254,Modify the molecule CN(C(=O)c1ccc(-c2ccncc2)[nH]c1=O)c1ccccc1F to decrease its LogP value.,CN(C(=O)c1ccc(-c2ccncc2)[nH]c1=O)c1ccccc1F,2.8526000000000007
66871,Please modify the molecule C[C@@H]([NH2+]Cc1ccc(-n2cccn2)cc1)c1ccc(N2CCCC2=O)cc1 to decrease its LogP value.,C[C@@H]([NH2+]Cc1ccc(-n2cccn2)cc1)c1ccc(N2CCCC2=O)cc1,2.8237000000000005
78396,Please optimize the molecule Cc1ccc(CC(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)cc1O to have a higher LogP value.,Cc1ccc(CC(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)cc1O,3.106920000000002
8198,Optimize the molecule C[C@H](NC(=O)[C@@H](C)Oc1ccc(Cl)cc1Br)C(=O)[O-] to have a lower LogP value.,C[C@H](NC(=O)[C@@H](C)Oc1ccc(Cl)cc1Br)C(=O)[O-],1.1243999999999998
199027,Modify the molecule Cc1cc(C)n(NC(=O)[C@H](C)n2nc(C(F)(F)F)c(Cl)c2C)c(=O)c1 to have a higher LogP value.,Cc1cc(C)n(NC(=O)[C@H](C)n2nc(C(F)(F)F)c(Cl)c2C)c(=O)c1,2.973560000000001
235695,Please optimize the molecule CCOc1ccccc1NC(=O)N[C@@H](C)c1c(-n2cccc2)sc2c1CC[NH+](CC)C2 to have a lower LogP value.,CCOc1ccccc1NC(=O)N[C@@H](C)c1c(-n2cccc2)sc2c1CC[NH+](CC)C2,3.781100000000002
82885,Modify the molecule CN(C(=O)c1cc2ccccc2n1C)[C@@H]1CCCC[C@H]1S(C)(=O)=O to have a higher LogP value.,CN(C(=O)c1cc2ccccc2n1C)[C@@H]1CCCC[C@H]1S(C)(=O)=O,2.6061000000000005
37855,Modify the molecule C#CC[NH+]1CCC[C@H]1COC(=O)c1cnc2c(C)cccn2c1=O to increase its LogP value.,C#CC[NH+]1CCC[C@H]1COC(=O)c1cnc2c(C)cccn2c1=O,-0.15978000000000026
57902,Please optimize the molecule Cc1cc(Cl)ncc1NC(=O)C(=O)N[C@H]1C[C@H]2CCCc3cccc1c32 to have a higher LogP value.,Cc1cc(Cl)ncc1NC(=O)C(=O)N[C@H]1C[C@H]2CCCc3cccc1c32,3.663020000000003
89548,Modify the molecule Cc1cn2c3c(=O)n(CC[NH+]4CCCCC4)c(=O)n(C)c3nc2n1-c1ccc(Cl)cc1 to increase its LogP value.,Cc1cn2c3c(=O)n(CC[NH+]4CCCCC4)c(=O)n(C)c3nc2n1-c1ccc(Cl)cc1,1.16922
11408,Modify the molecule O=C(CC1CC1)c1scc(Br)c1Br to decrease its LogP value.,O=C(CC1CC1)c1scc(Br)c1Br,4.255900000000001
30507,Please optimize the molecule FCCC[NH+]1CCC[C@H](c2nncn2C2CC2)C1 to have a lower LogP value.,FCCC[NH+]1CCC[C@H](c2nncn2C2CC2)C1,0.7348999999999994
210334,Modify the molecule COc1cc(C[NH2+]Cc2ccccn2)ccc1OC(F)F to decrease its LogP value.,COc1cc(C[NH2+]Cc2ccccn2)ccc1OC(F)F,1.9551999999999994
53937,Modify the molecule CC(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1 to have a lower LogP value.,CC(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1,0.7855999999999999
189009,Please modify the molecule CSc1ccccc1Oc1cncc(C[NH2+]CC(C)C)n1 to decrease its LogP value.,CSc1ccccc1Oc1cncc(C[NH2+]CC(C)C)n1,2.7102000000000004
138514,Please modify the molecule CNC(=S)Nc1n[nH]c(SC)n1 to increase its LogP value.,CNC(=S)Nc1n[nH]c(SC)n1,0.4427999999999998
121280,Please modify the molecule CCN(C(=O)c1cncc(Br)c1)c1ccc2ccccc2c1 to increase its LogP value.,CCN(C(=O)c1cncc(Br)c1)c1ccc2ccccc2c1,4.664000000000003
165164,Please modify the molecule COc1cccc(CNC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)c1 to increase its LogP value.,COc1cccc(CNC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)c1,2.3924000000000003
239937,Modify the molecule Clc1cccc(Cl)c1N[C@@H]1CCO[C@@]2(CCOC2)C1 to have a higher LogP value.,Clc1cccc(Cl)c1N[C@@H]1CCO[C@@]2(CCOC2)C1,3.743400000000003
165559,Modify the molecule CCc1nn(C)cc1C[NH2+][C@@H]1CCCSC1 to have a higher LogP value.,CCc1nn(C)cc1C[NH2+][C@@H]1CCCSC1,0.9415000000000001
73100,Please modify the molecule COC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C to decrease its LogP value.,COC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C,2.5851200000000008
165773,Optimize the molecule CN(Cc1ccccc1)C(=O)c1c[nH]nc1[C@H]1CCCN(Cc2ccccc2F)C1 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)c1c[nH]nc1[C@H]1CCCN(Cc2ccccc2F)C1,4.200600000000003
90114,Please optimize the molecule COc1ccc(-c2noc(C[NH+]3CC[C@@H](C(N)=O)C3)n2)cc1 to have a higher LogP value.,COc1ccc(-c2noc(C[NH+]3CC[C@@H](C(N)=O)C3)n2)cc1,-0.36469999999999847
195586,Modify the molecule Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl to increase its LogP value.,Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl,2.820900000000001
236930,Optimize the molecule CC[C@H](C#N)Oc1cccc(C[NH2+][C@@H](C)c2ccc(C)cc2)c1 to have a higher LogP value.,CC[C@H](C#N)Oc1cccc(C[NH2+][C@@H](C)c2ccc(C)cc2)c1,3.500600000000002
104327,Modify the molecule CCOC(=O)C1C(C)=NC2=C(C(=O)[C@H](C(=O)OC)[C@@H](C)C2)[C@H]1c1ccc(SC)cc1 to have a higher LogP value.,CCOC(=O)C1C(C)=NC2=C(C(=O)[C@H](C(=O)OC)[C@@H](C)C2)[C@H]1c1ccc(SC)cc1,3.7981000000000034
190947,Please modify the molecule c1nc(N2CCOCC2)ncc1CNCC1([NH+]2CCCCC2)CCCCC1 to increase its LogP value.,c1nc(N2CCOCC2)ncc1CNCC1([NH+]2CCCCC2)CCCCC1,1.1745000000000012
33733,Optimize the molecule CC[C@H](C)NC(=O)C(=O)Nc1cc(Cl)ccc1C(=O)N1CCCC1 to have a lower LogP value.,CC[C@H](C)NC(=O)C(=O)Nc1cc(Cl)ccc1C(=O)N1CCCC1,2.4292000000000007
211622,Please optimize the molecule COC(=O)CN(C(C)C)S(=O)(=O)c1cc(C)ccc1C to have a higher LogP value.,COC(=O)CN(C(C)C)S(=O)(=O)c1cc(C)ccc1C,1.8755399999999998
31962,Please optimize the molecule Cc1ccc(CNC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)CCCC(=O)N3)o1 to have a lower LogP value.,Cc1ccc(CNC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)CCCC(=O)N3)o1,1.7997200000000002
249316,Optimize the molecule CC(C)Cc1nnc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)s1 to have a higher LogP value.,CC(C)Cc1nnc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)s1,1.6083999999999998
118077,Modify the molecule O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1 to decrease its LogP value.,O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1,2.5222999999999995
195849,Modify the molecule C[C@H](NC(=O)COc1ccc(C(=O)[O-])cc1)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)COc1ccc(C(=O)[O-])cc1)C1CC1,0.3435999999999997
126689,Modify the molecule C[NH+]1CCCC[C@H]1CN1CCN(Cc2cc(-c3ccccc3)[nH]n2)CC1 to increase its LogP value.,C[NH+]1CCCC[C@H]1CN1CCN(Cc2cc(-c3ccccc3)[nH]n2)CC1,1.2615000000000014
172407,Modify the molecule CCOc1ccc(C(=O)NC(=S)Nc2nnn(C)n2)cc1 to decrease its LogP value.,CCOc1ccc(C(=O)NC(=S)Nc2nnn(C)n2)cc1,0.7355999999999995
149368,Modify the molecule CCC(C)(C)N(C)C(=O)/C=C/c1cccc(C)c1 to decrease its LogP value.,CCC(C)(C)N(C)C(=O)/C=C/c1cccc(C)c1,3.6552200000000026
60436,Optimize the molecule COC(=O)c1ccc(NCC2CCOCC2)c(F)c1F to have a lower LogP value.,COC(=O)c1ccc(NCC2CCOCC2)c(F)c1F,2.589900000000001
73484,Please optimize the molecule Cc1nn(C)cc1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1Cc1ccc2ccccc2c1 to have a higher LogP value.,Cc1nn(C)cc1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1Cc1ccc2ccccc2c1,0.8137200000000018
140527,Modify the molecule Cn1nccc1CNC(=O)NC[C@@H]1CCC[C@H]1O to have a lower LogP value.,Cn1nccc1CNC(=O)NC[C@@H]1CCC[C@H]1O,0.38029999999999947
152837,Please optimize the molecule COCCc1noc(-c2cc(Cl)ccc2NC(=O)[C@@H]2CCCS2)n1 to have a higher LogP value.,COCCc1noc(-c2cc(Cl)ccc2NC(=O)[C@@H]2CCCS2)n1,3.413000000000001
67997,Optimize the molecule O=C(Nc1nnn[n-]1)c1ccc(OCC(F)F)nc1 to have a higher LogP value.,O=C(Nc1nnn[n-]1)c1ccc(OCC(F)F)nc1,0.11999999999999988
116798,Please modify the molecule C=CC[NH+]1CCC(NC(=O)N2CCN(CCOC(C)C)CC2)CC1 to decrease its LogP value.,C=CC[NH+]1CCC(NC(=O)N2CCN(CCOC(C)C)CC2)CC1,-0.028099999999996017
212251,Please modify the molecule CC(=O)c1ccc(NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c([N+](=O)[O-])c1 to increase its LogP value.,CC(=O)c1ccc(NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c([N+](=O)[O-])c1,3.4219000000000017
200676,Optimize the molecule Cn1ccs/c1=N\C(=O)Nc1ccccc1 to have a higher LogP value.,Cn1ccs/c1=N\C(=O)Nc1ccccc1,2.2194000000000003
78235,Please optimize the molecule Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N to have a higher LogP value.,Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N,1.4976
52360,Optimize the molecule CNC(=O)c1ccc(C[S@](=O)[C@H](C)C(=O)Nc2ccccc2F)cc1 to have a higher LogP value.,CNC(=O)c1ccc(C[S@](=O)[C@H](C)C(=O)Nc2ccccc2F)cc1,2.4612000000000007
169616,Modify the molecule CS[C@@H](C)c1cccc(NC(=O)c2c(C)c(C)nn(C)c2=O)c1 to decrease its LogP value.,CS[C@@H](C)c1cccc(NC(=O)c2c(C)c(C)nn(C)c2=O)c1,3.0734400000000015
117239,Optimize the molecule c1ccc(Oc2ccc3c(c2)c2c4n3CC[NH2+][C@@H]4CCC2)cc1 to have a higher LogP value.,c1ccc(Oc2ccc3c(c2)c2c4n3CC[NH2+][C@@H]4CCC2)cc1,3.3880000000000017
70124,Optimize the molecule O=C(NC1CCCCC1)NC1C[C@@H]2CCC[C@H](C1)[NH2+]2 to have a higher LogP value.,O=C(NC1CCCCC1)NC1C[C@@H]2CCC[C@H](C1)[NH2+]2,1.2652000000000005
70768,Please optimize the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)NCc1ccc(NC(=O)C2CC2)cc1 to have a higher LogP value.,Cc1nc2c(cnn2C(C)C)cc1C(=O)NCc1ccc(NC(=O)C2CC2)cc1,3.599120000000002
49820,Modify the molecule CCCOc1ccc(CNC(=O)N[C@H](C)c2nc(C)cs2)cc1 to decrease its LogP value.,CCCOc1ccc(CNC(=O)N[C@H](C)c2nc(C)cs2)cc1,3.800720000000002
174735,Modify the molecule COc1ccc2nc(C[NH+]3CCC(c4nnc(-c5ccncc5)o4)CC3)ccc2c1 to have a lower LogP value.,COc1ccc2nc(C[NH+]3CCC(c4nnc(-c5ccncc5)o4)CC3)ccc2c1,2.650900000000001
91753,Please optimize the molecule O=C(CCCl)Nc1ccc(NC(=O)c2ccccc2)cc1 to have a lower LogP value.,O=C(CCCl)Nc1ccc(NC(=O)c2ccccc2)cc1,3.5063000000000013
95220,Modify the molecule N#Cc1cc(NC(=O)C2(O)Cc3ccccc3C2)ccc1F to decrease its LogP value.,N#Cc1cc(NC(=O)C2(O)Cc3ccccc3C2)ccc1F,2.16578
76239,Please optimize the molecule CO[C@@H](C)c1cccc(NC(=O)C(=O)N[C@H](C)c2cn(C)nc2C)c1 to have a lower LogP value.,CO[C@@H](C)c1cccc(NC(=O)C(=O)N[C@H](C)c2cn(C)nc2C)c1,2.2518200000000004
34817,Please optimize the molecule Cc1cc(C)c2c(c1)[C@H]([NH2+]C[C@H]1CCCS1(=O)=O)CCO2 to have a higher LogP value.,Cc1cc(C)c2c(c1)[C@H]([NH2+]C[C@H]1CCCS1(=O)=O)CCO2,1.2676399999999999
83212,Modify the molecule COc1ccccc1Nc1ncccc1C(=O)Nc1ccc(C)c(S(N)(=O)=O)c1 to decrease its LogP value.,COc1ccccc1Nc1ncccc1C(=O)Nc1ccc(C)c(S(N)(=O)=O)c1,3.04192
51571,Optimize the molecule C[C@H]1CN(c2ccc(C#N)c([N+](=O)[O-])c2)C[C@@H]1C to have a lower LogP value.,C[C@H]1CN(c2ccc(C#N)c([N+](=O)[O-])c2)C[C@@H]1C,2.5586800000000007
113766,Please modify the molecule CCc1nc(CNc2cccc(Cl)c2-n2cccn2)no1 to decrease its LogP value.,CCc1nc(CNc2cccc(Cl)c2-n2cccn2)no1,3.0832000000000006
12651,Please modify the molecule C[C@H]1Oc2ccccc2N(CCC(=O)N(Cc2cccs2)C[C@H]2CCCO2)C1=O to increase its LogP value.,C[C@H]1Oc2ccccc2N(CCC(=O)N(Cc2cccs2)C[C@H]2CCCO2)C1=O,3.459900000000002
10149,Optimize the molecule Cc1noc(CN2CCOC[C@@H]2C2CC2)n1 to have a lower LogP value.,Cc1noc(CN2CCOC[C@@H]2C2CC2)n1,0.9888199999999998
2327,Please modify the molecule COc1ccc(-c2onc(C(=O)c3ccc([N+](=O)[O-])cc3)c2S(=O)(=O)c2ccccc2)cc1 to increase its LogP value.,COc1ccc(-c2onc(C(=O)c3ccc([N+](=O)[O-])cc3)c2S(=O)(=O)c2ccccc2)cc1,4.322200000000003
192255,Optimize the molecule CC(C)N(C)C(=O)[C@@H](C)S(=O)(=O)c1ccccc1 to have a lower LogP value.,CC(C)N(C)C(=O)[C@@H](C)S(=O)(=O)c1ccccc1,1.7156
36246,Please optimize the molecule CCOc1cc2oc(=O)cc(C)c2cc1CC to have a higher LogP value.,CCOc1cc2oc(=O)cc(C)c2cc1CC,3.062520000000002
136768,Please modify the molecule CC(C)Oc1ccc([C@@H]2CC(=O)Nc3c(C(=O)[O-])nsc32)cc1 to increase its LogP value.,CC(C)Oc1ccc([C@@H]2CC(=O)Nc3c(C(=O)[O-])nsc32)cc1,1.7678999999999998
204257,Modify the molecule CCOC(=O)C[C@@H](C)[C@H]1CCCN(c2ncnc3nc(N)ccc23)C1 to increase its LogP value.,CCOC(=O)C[C@@H](C)[C@H]1CCCN(c2ncnc3nc(N)ccc23)C1,2.4127
131602,Optimize the molecule CCCCCn1c(N)c(-c2nc3ccccc3o2)c2c([N+](=O)[O-])nn(C)c(=O)c21 to have a higher LogP value.,CCCCCn1c(N)c(-c2nc3ccccc3o2)c2c([N+](=O)[O-])nn(C)c(=O)c21,3.2238000000000016
101124,Please modify the molecule C[C@@H]1CCC[C@@H](NC(=S)NNC(=O)c2cccc(-n3cccn3)n2)[C@@H]1C to decrease its LogP value.,C[C@@H]1CCC[C@@H](NC(=S)NNC(=O)c2cccc(-n3cccn3)n2)[C@@H]1C,2.2009
230520,Modify the molecule CN(C[C@@H]1CCC[NH+]1C)[C@@H](C[NH3+])c1cc(Br)ccc1F to increase its LogP value.,CN(C[C@@H]1CCC[NH+]1C)[C@@H](C[NH3+])c1cc(Br)ccc1F,0.4801000000000017
245554,Optimize the molecule COCCN(CC(=O)N(C)C)c1ccc2nnc(C)n2n1 to have a lower LogP value.,COCCN(CC(=O)N(C)C)c1ccc2nnc(C)n2n1,-0.02628000000000008
228186,Optimize the molecule CCC(=O)N1CC[C@@H](NC(=O)Nc2ccnn2Cc2ccccn2)C1 to have a lower LogP value.,CCC(=O)N1CC[C@@H](NC(=O)Nc2ccnn2Cc2ccccn2)C1,1.4587999999999994
83493,Modify the molecule C[C@@H](C(=O)N(C)Cc1ccccc1)[S@](=O)Cc1ncc(Cl)n1C to increase its LogP value.,C[C@@H](C(=O)N(C)Cc1ccccc1)[S@](=O)Cc1ncc(Cl)n1C,2.3693
228527,Modify the molecule Cc1ccc([C@@H](CNC(=O)C2CCCCC2)N2CCOCC2)o1 to increase its LogP value.,Cc1ccc([C@@H](CNC(=O)C2CCCCC2)N2CCOCC2)o1,2.657820000000001
133453,Please optimize the molecule Cc1cc(C)n(C2CN(C(=O)c3cnn4ccn(C)c34)C2)n1 to have a lower LogP value.,Cc1cc(C)n(C2CN(C(=O)c3cnn4ccn(C)c34)C2)n1,1.1832399999999998
114260,Modify the molecule O[C@@H](c1ccc(F)c(F)c1)[C@@H]1CCOC2(CCC2)C1 to have a higher LogP value.,O[C@@H](c1ccc(F)c(F)c1)[C@@H]1CCOC2(CCC2)C1,3.347500000000002
162559,Please modify the molecule CCO[n+]1ccc(-c2cc[n+](OCC)cc2)cc1 to decrease its LogP value.,CCO[n+]1ccc(-c2cc[n+](OCC)cc2)cc1,0.8255999999999997
140367,Optimize the molecule COc1ccccc1NC(=O)c1ccc(-n2cccn2)nn1 to have a higher LogP value.,COc1ccccc1NC(=O)c1ccc(-n2cccn2)nn1,1.9231999999999996
76583,Modify the molecule Cc1ccc(CN2C(=O)[C@H]3CCCC[C@@H]3C2=O)cc1S(=O)(=O)Nc1cccc(Cl)c1C to have a higher LogP value.,Cc1ccc(CN2C(=O)[C@H]3CCCC[C@@H]3C2=O)cc1S(=O)(=O)Nc1cccc(Cl)c1C,4.432840000000003
136785,Modify the molecule CSC[C@@H](C)NC(=O)N(CC1CC1)[C@H](C)c1ccccc1 to increase its LogP value.,CSC[C@@H](C)NC(=O)N(CC1CC1)[C@H](C)c1ccccc1,3.9207000000000036
105205,Modify the molecule CN(C)C(C)(C)[C@H]([NH3+])[C@H]1CCOC2(CCC2)C1 to increase its LogP value.,CN(C)C(C)(C)[C@H]([NH3+])[C@H]1CCOC2(CCC2)C1,1.2864
226338,Please optimize the molecule Cc1nc(CC(C)C)sc1C(=O)NC[C@](C)(O)c1ccsc1 to have a lower LogP value.,Cc1nc(CC(C)C)sc1C(=O)NC[C@](C)(O)c1ccsc1,3.349020000000002
130635,Please modify the molecule CCCN(C(=O)c1[nH]c(C)c(C(=O)OCC)c1C)[C@H]1CCc2ccccc2C1 to decrease its LogP value.,CCCN(C(=O)c1[nH]c(C)c(C(=O)OCC)c1C)[C@H]1CCc2ccccc2C1,4.217940000000004
205789,Please modify the molecule CO[C@@H](C)C(=O)NCCOc1ccc(C)cc1 to decrease its LogP value.,CO[C@@H](C)C(=O)NCCOc1ccc(C)cc1,1.5249199999999996
233851,Modify the molecule Cc1ccc2oc(C(=O)Nc3cccc(C(F)(F)F)c3)cc2n1 to have a lower LogP value.,Cc1ccc2oc(C(=O)Nc3cccc(C(F)(F)F)c3)cc2n1,4.407320000000002
28864,Modify the molecule C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C to decrease its LogP value.,C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C,5.258400000000004
22456,Modify the molecule CC[C@H](C)[C@H](C(=O)Nc1nnc(N)s1)c1ccccc1 to have a higher LogP value.,CC[C@H](C)[C@H](C(=O)Nc1nnc(N)s1)c1ccccc1,2.888700000000001
27273,Modify the molecule ClCc1cnc(-c2cccs2)nc1 to decrease its LogP value.,ClCc1cnc(-c2cccs2)nc1,2.943900000000001
92806,Please modify the molecule O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N1CCOC[C@H]1C1CC1 to increase its LogP value.,O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N1CCOC[C@H]1C1CC1,3.333400000000002
15037,Optimize the molecule COc1cc(NC2CC[NH+]([C@H](C)C(=O)NC3CCCC3)CC2)cc(OC)c1 to have a lower LogP value.,COc1cc(NC2CC[NH+]([C@H](C)C(=O)NC3CCCC3)CC2)cc(OC)c1,1.6103
136878,Please optimize the molecule CC(=O)Nc1cc(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])ccc1C to have a higher LogP value.,CC(=O)Nc1cc(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])ccc1C,3.5134200000000018
1914,Please optimize the molecule Cc1ccccc1NC(=O)N1CCN(Cc2cc(=O)n3nc(-c4ccccc4F)sc3n2)CC1 to have a higher LogP value.,Cc1ccccc1NC(=O)N1CCN(Cc2cc(=O)n3nc(-c4ccccc4F)sc3n2)CC1,3.6152200000000025
141937,Please modify the molecule COCCNC(=O)[C@H](C)N1CCc2cc(Br)sc2C1 to decrease its LogP value.,COCCNC(=O)[C@H](C)N1CCc2cc(Br)sc2C1,2.0198
95055,Optimize the molecule Cc1noc(C)c1C[NH+]1CCC(C[NH+](C)Cc2ccccc2)CC1 to have a higher LogP value.,Cc1noc(C)c1C[NH+]1CCC(C[NH+](C)Cc2ccccc2)CC1,0.8012400000000024
149243,Modify the molecule N#C[C@]1(N)CCC[C@H]1CCOc1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,N#C[C@]1(N)CCC[C@H]1CCOc1ccc([N+](=O)[O-])cc1,2.3848800000000008
6409,Modify the molecule Cc1cc(NC(=O)C(=O)c2ccc(C(C)(C)C)cc2)n(C)n1 to have a lower LogP value.,Cc1cc(NC(=O)C(=O)c2ccc(C(C)(C)C)cc2)n(C)n1,2.8474200000000014
174214,Optimize the molecule CN1CCO[C@@H](C[NH2+]CC2CCCCCC2)C1 to have a higher LogP value.,CN1CCO[C@@H](C[NH2+]CC2CCCCCC2)C1,0.8508000000000004
99942,Please modify the molecule COc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc(C)cc1 to increase its LogP value.,COc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc(C)cc1,2.964120000000001
205986,Please optimize the molecule Cc1ccc(OC[C@H]2CCCN(C(=O)CCc3cnn(C)c3)C2)cc1 to have a higher LogP value.,Cc1ccc(OC[C@H]2CCCN(C(=O)CCc3cnn(C)c3)C2)cc1,2.978720000000002
9662,Modify the molecule CC(C)OCCN1CCN(C(=O)[C@H](C(C)C)N2C[C@@H](C)O[C@H](C)C2)CC1 to have a higher LogP value.,CC(C)OCCN1CCN(C(=O)[C@H](C(C)C)N2C[C@@H](C)O[C@H](C)C2)CC1,1.6894000000000013
135965,Modify the molecule CCCCC(=O)[C@H]1CCCc2cccnc21 to increase its LogP value.,CCCCC(=O)[C@H]1CCCc2cccnc21,3.2608000000000024
139821,Modify the molecule O=C(CSc1nc2ccccc2[nH]1)N/N=C1/C(=O)N(Cc2ccccc2)c2ccccc21 to have a higher LogP value.,O=C(CSc1nc2ccccc2[nH]1)N/N=C1/C(=O)N(Cc2ccccc2)c2ccccc21,3.7223000000000024
187740,Modify the molecule CCOc1ccc([C@H](O)C[NH+]2CCC(C)(C)C2)cc1 to increase its LogP value.,CCOc1ccc([C@H](O)C[NH+]2CCC(C)(C)C2)cc1,1.4334999999999996
19169,Modify the molecule CCn1c(=O)n(CCC(=O)N2CCC[C@@H]2c2ccc(OC)c(OC)c2)c2ccccc21 to have a higher LogP value.,CCn1c(=O)n(CCC(=O)N2CCC[C@@H]2c2ccc(OC)c(OC)c2)c2ccccc21,3.5939000000000023
46840,Modify the molecule Cc1cc(NC(=O)C(=O)NCC2CCN(C(=O)/C=C/c3ccco3)CC2)c2ccccc2n1 to decrease its LogP value.,Cc1cc(NC(=O)C(=O)NCC2CCN(C(=O)/C=C/c3ccco3)CC2)c2ccccc2n1,3.142920000000001
12751,Please optimize the molecule O=C(Cn1ncn(-n2cccc2)c1=S)Nc1ccc(F)cc1F to have a higher LogP value.,O=C(Cn1ncn(-n2cccc2)c1=S)Nc1ccc(F)cc1F,2.4438899999999997
214064,Please optimize the molecule Cc1[nH+]ccn1CCOc1c(F)cc(C[C@@H](C)[NH3+])cc1F to have a higher LogP value.,Cc1[nH+]ccn1CCOc1c(F)cc(C[C@@H](C)[NH3+])cc1F,1.1407199999999997
6491,Optimize the molecule C[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)[O-] to have a higher LogP value.,C[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)[O-],0.5232999999999997
249091,Modify the molecule O=C(CNC(=O)NCCCN1CCCCCC1=O)Nc1ccc(F)c(F)c1 to have a higher LogP value.,O=C(CNC(=O)NCCCN1CCCCCC1=O)Nc1ccc(F)c(F)c1,1.9951999999999992
85589,Optimize the molecule Cn1c(C(=O)N2CCCO[C@H](Cn3cccn3)C2)cc(=O)n(C)c1=O to have a lower LogP value.,Cn1c(C(=O)N2CCCO[C@H](Cn3cccn3)C2)cc(=O)n(C)c1=O,-0.7881999999999985
236403,Modify the molecule Cc1nc(CCC[S@](=O)C2CCCC2)cs1 to have a lower LogP value.,Cc1nc(CCC[S@](=O)C2CCCC2)cs1,3.075420000000002
97449,Modify the molecule Cc1ccc(C)c(S(=O)(=O)c2nnn3c2nc(N(C)Cc2ccccc2)c2sccc23)c1 to have a higher LogP value.,Cc1ccc(C)c(S(=O)(=O)c2nnn3c2nc(N(C)Cc2ccccc2)c2sccc23)c1,4.425040000000004
7182,Modify the molecule NS(=O)(=O)c1ccc(Cl)c(C(=O)NCc2ccco2)c1 to have a higher LogP value.,NS(=O)(=O)c1ccc(Cl)c(C(=O)NCc2ccco2)c1,1.5104000000000002
198493,Modify the molecule COC[C@H](C)NC(=O)c1ccccc1SC[C@H]1CCCO1 to decrease its LogP value.,COC[C@H](C)NC(=O)c1ccccc1SC[C@H]1CCCO1,2.7224000000000013
171506,Optimize the molecule Cc1ccc(C)c(NC(=O)COC(=O)c2cccc(N(C)C)c2)c1 to have a lower LogP value.,Cc1ccc(C)c(NC(=O)COC(=O)c2cccc(N(C)C)c2)c1,3.1649400000000014
75170,Please optimize the molecule CCCCn1c(N)c(N(Cc2ccccc2)C(=O)c2ccc(Cl)c(Cl)c2)c(=O)[nH]c1=O to have a higher LogP value.,CCCCn1c(N)c(N(Cc2ccccc2)C(=O)c2ccc(Cl)c(Cl)c2)c(=O)[nH]c1=O,4.072700000000002
60509,Modify the molecule C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1 to decrease its LogP value.,C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1,4.782100000000004
150118,Please modify the molecule CCC1CN(c2cccc(F)c2C(=O)[O-])C1 to decrease its LogP value.,CCC1CN(c2cccc(F)c2C(=O)[O-])C1,1.0353999999999999
8165,Modify the molecule COc1ccc([C@H]2C(C#N)=C(N)Oc3cc(C)n(Cc4ccccc4)c(=O)c32)cc1OC to have a lower LogP value.,COc1ccc([C@H]2C(C#N)=C(N)Oc3cc(C)n(Cc4ccccc4)c(=O)c32)cc1OC,3.440400000000002
224654,Modify the molecule CN(C)CN1C(=O)/C(=N\c2sc3c(c2C#N)CCCC3)c2cc(Br)ccc21 to decrease its LogP value.,CN(C)CN1C(=O)/C(=N\c2sc3c(c2C#N)CCCC3)c2cc(Br)ccc21,4.247580000000004
78271,Optimize the molecule O=C(c1cccc2c1N[C@@H](c1cccc3ccccc13)[C@H]1CC=C[C@H]21)N1CCCC1 to have a lower LogP value.,O=C(c1cccc2c1N[C@@H](c1cccc3ccccc13)[C@H]1CC=C[C@H]21)N1CCCC1,5.902300000000005
179089,Please optimize the molecule Cc1ccc(-c2cc(C(=O)Nc3nccs3)no2)cc1F to have a higher LogP value.,Cc1ccc(-c2cc(C(=O)Nc3nccs3)no2)cc1F,3.4979200000000015
67122,Optimize the molecule CC(=O)Nc1cccc2c1CCN(C(=O)c1[nH]c3ccccc3c1Cl)C2 to have a lower LogP value.,CC(=O)Nc1cccc2c1CCN(C(=O)c1[nH]c3ccccc3c1Cl)C2,3.978200000000002
233330,Please modify the molecule O=C([O-])c1cc2n[nH]cc2cc1[N+](=O)[O-] to increase its LogP value.,O=C([O-])c1cc2n[nH]cc2cc1[N+](=O)[O-],-0.16540000000000016
35493,Modify the molecule CCOc1ccc(CCC2CCN(C(=O)c3cccnc3-n3cncn3)CC2)cc1 to increase its LogP value.,CCOc1ccc(CCC2CCN(C(=O)c3cccnc3-n3cncn3)CC2)cc1,3.546000000000002
109197,Modify the molecule Cc1c(OCC(=O)NC(=O)N[C@@H]2CCCC[C@H]2C)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(OCC(=O)NC(=O)N[C@@H]2CCCC[C@H]2C)cccc1[N+](=O)[O-],2.6865200000000007
175039,Modify the molecule C#CCN(CC#C)C(=O)c1cncc(C(=O)N(CC#C)CC#C)c1 to have a higher LogP value.,C#CCN(CC#C)C(=O)c1cncc(C(=O)N(CC#C)CC#C)c1,0.49880000000000013
170371,Optimize the molecule Cn1ncc2c(=O)n(CC(=O)c3ccc4c(c3)OCCO4)cnc21 to have a lower LogP value.,Cn1ncc2c(=O)n(CC(=O)c3ccc4c(c3)OCCO4)cnc21,0.7840999999999995
9842,Modify the molecule C[C@@H](OC1=C[C@H]2[NH+]=c3ccccc3=C2C=C1)C(=O)Nc1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,C[C@@H](OC1=C[C@H]2[NH+]=c3ccccc3=C2C=C1)C(=O)Nc1ccc(S(N)(=O)=O)cc1,-0.9353999999999969
245056,Modify the molecule CCOc1ccc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 to increase its LogP value.,CCOc1ccc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1,3.158800000000001
125240,Modify the molecule CC(C)n1ncc2cc(/C=C/C(=O)Oc3ccccc3Cl)c(=O)[nH]c21 to increase its LogP value.,CC(C)n1ncc2cc(/C=C/C(=O)Oc3ccccc3Cl)c(=O)[nH]c21,3.577700000000002
63053,Optimize the molecule O=c1c(/C([O-])=N/c2nc(-c3ccc(Cl)cc3)cs2)c[nH]c2cc(F)cc(F)c12 to have a lower LogP value.,O=c1c(/C([O-])=N/c2nc(-c3ccc(Cl)cc3)cs2)c[nH]c2cc(F)cc(F)c12,4.021800000000002
191532,Optimize the molecule O=C([O-])[C@H](Sc1nnc(-c2ccncc2)n1-c1ccccc1)c1ccccc1 to have a higher LogP value.,O=C([O-])[C@H](Sc1nnc(-c2ccncc2)n1-c1ccccc1)c1ccccc1,2.912600000000001
212819,Please modify the molecule O=Cc1cc([N+](=O)[O-])ccc1OCc1cc(=O)oc2cc3c(cc12)CCC3 to increase its LogP value.,O=Cc1cc([N+](=O)[O-])ccc1OCc1cc(=O)oc2cc3c(cc12)CCC3,3.581400000000002
218501,Optimize the molecule C[C@H](C(N)=O)N1CCN(Cc2cnc(-c3cccs3)s2)CC1 to have a lower LogP value.,C[C@H](C(N)=O)N1CCN(Cc2cnc(-c3cccs3)s2)CC1,1.8630000000000002
176144,Please modify the molecule Cc1ccccc1CNC(=O)CCc1ccc2[nH]ccc2c1 to increase its LogP value.,Cc1ccccc1CNC(=O)CCc1ccc2[nH]ccc2c1,3.7253200000000017
80342,Optimize the molecule Cc1ccc(C(=O)Nc2ccc3c(c2)nc2n3CCSC2)cc1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2ccc3c(c2)nc2n3CCSC2)cc1,3.843820000000002
43491,Optimize the molecule COC(=O)C1=C(C)C(C(=O)c2cc3ccccc3o2)=N[C@H]1C to have a higher LogP value.,COC(=O)C1=C(C)C(C(=O)c2cc3ccccc3o2)=N[C@H]1C,2.948100000000001
126075,Modify the molecule O=C(NCc1nnnn1-c1ccc(Cl)cc1)c1cccc2ccccc12 to have a lower LogP value.,O=C(NCc1nnnn1-c1ccc(Cl)cc1)c1cccc2ccccc12,3.398900000000002
140046,Optimize the molecule C[C@H]1CCCCN1C(=O)Cn1c(CCCNC(=O)c2cccnc2)nc2ccccc21 to have a lower LogP value.,C[C@H]1CCCCN1C(=O)Cn1c(CCCNC(=O)c2cccnc2)nc2ccccc21,3.1949000000000014
92290,Optimize the molecule Cc1ccc(C(=O)NNC(=O)N[C@H](CC(F)(F)F)c2ccc(F)cc2)s1 to have a lower LogP value.,Cc1ccc(C(=O)NNC(=O)N[C@H](CC(F)(F)F)c2ccc(F)cc2)s1,3.8333200000000014
216726,Please optimize the molecule C[C@H](CO)N(C)C(=O)NC[C@H]1CCCN(c2ncccn2)C1 to have a higher LogP value.,C[C@H](CO)N(C)C(=O)NC[C@H]1CCCN(c2ncccn2)C1,0.7151999999999996
164755,Optimize the molecule CN(CCN1CCOCC1)[C@@H](C(N)=O)c1ccccc1 to have a higher LogP value.,CN(CCN1CCOCC1)[C@@H](C(N)=O)c1ccccc1,0.4770000000000011
171727,Modify the molecule C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C to have a higher LogP value.,C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C,0.8544
113197,Please optimize the molecule CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc2sccc2c1 to have a lower LogP value.,CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc2sccc2c1,2.9373000000000014
49061,Please optimize the molecule COc1cccc([C@H](CO)Nc2ccc(-n3ccc(C)n3)nn2)c1 to have a higher LogP value.,COc1cccc([C@H](CO)Nc2ccc(-n3ccc(C)n3)nn2)c1,2.1248199999999997
68212,Please optimize the molecule CCc1nc2n(n1)[C@@H](C(=O)Nc1ccc(C(C)=O)cc1)CC(=O)N2 to have a lower LogP value.,CCc1nc2n(n1)[C@@H](C(=O)Nc1ccc(C(C)=O)cc1)CC(=O)N2,1.5650999999999997
81989,Optimize the molecule C1C[NH2+]C[C@H](OCC2CC2)C1 to have a higher LogP value.,C1C[NH2+]C[C@H](OCC2CC2)C1,0.13880000000000026
139308,Optimize the molecule COc1cccc(CCNC(=O)N(C)C[C@@H](C)O)c1 to have a lower LogP value.,COc1cccc(CCNC(=O)N(C)C[C@@H](C)O)c1,1.2598999999999998
74611,Please modify the molecule O=c1ccc(-c2ccc(-n3ccnc3)cc2)n[nH]1 to decrease its LogP value.,O=c1ccc(-c2ccc(-n3ccnc3)cc2)n[nH]1,1.6225999999999998
189474,Modify the molecule Cc1ccc(-c2csc3c(=O)[nH]c(N4CCC[C@H](C(=O)NCC(C)C)C4)nc23)cc1 to increase its LogP value.,Cc1ccc(-c2csc3c(=O)[nH]c(N4CCC[C@H](C(=O)NCC(C)C)C4)nc23)cc1,3.9486200000000027
199947,Please modify the molecule COc1ccc(OC)c([C@@H](C)NCCc2ccncc2C)c1 to increase its LogP value.,COc1ccc(OC)c([C@@H](C)NCCc2ccncc2C)c1,3.3005200000000015
209938,Please modify the molecule Cc1cnc(C[NH2+][C@@H](C)[C@@H](C)O)cn1 to increase its LogP value.,Cc1cnc(C[NH2+][C@@H](C)[C@@H](C)O)cn1,-0.3822799999999993
176607,Optimize the molecule Cc1ccc(N2CCN(/N=C\c3ccc(C)o3)CC2)cc1 to have a higher LogP value.,Cc1ccc(N2CCN(/N=C\c3ccc(C)o3)CC2)cc1,3.0525400000000014
32079,Modify the molecule C[C@@H]1C[NH+](Cc2ccc(C#CC[NH3+])cc2F)C[C@H]1C to increase its LogP value.,C[C@@H]1C[NH+](Cc2ccc(C#CC[NH3+])cc2F)C[C@H]1C,0.08980000000000121
14804,Optimize the molecule O=C(NCCc1nnc2ccccn12)Nc1ccc(OC2CCCC2)cc1 to have a higher LogP value.,O=C(NCCc1nnc2ccccn12)Nc1ccc(OC2CCCC2)cc1,3.414900000000002
200547,Modify the molecule Cc1[nH+]ccn1CC(=O)N1CCC[C@@H](c2nnc(C[NH+]3CCCC3)n2C)C1 to increase its LogP value.,Cc1[nH+]ccn1CC(=O)N1CCC[C@@H](c2nnc(C[NH+]3CCCC3)n2C)C1,-0.6759799999999963
176551,Optimize the molecule C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2CNC(=O)NC1CCCCC1 to have a higher LogP value.,C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2CNC(=O)NC1CCCCC1,1.0976000000000008
156858,Optimize the molecule Cc1c(NC(=O)c2cccc(NC(=O)[C@H]3CC=CC[C@H]3C(=O)[O-])c2)c(=O)n(-c2ccccc2)n1C to have a higher LogP value.,Cc1c(NC(=O)c2cccc(NC(=O)[C@H]3CC=CC[C@H]3C(=O)[O-])c2)c(=O)n(-c2ccccc2)n1C,2.0075199999999995
34342,Optimize the molecule C[C@@H](NC(=O)CSCc1ccco1)c1ccccc1Cl to have a lower LogP value.,C[C@@H](NC(=O)CSCc1ccco1)c1ccccc1Cl,4.043600000000003
154525,Modify the molecule Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1 to decrease its LogP value.,Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1,3.454220000000001
103531,Modify the molecule COc1ccccc1[C@@H](NC(=O)NCC[NH+]1CCCCC1)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@@H](NC(=O)NCC[NH+]1CCCCC1)c1ccccn1,1.5476
127093,Please optimize the molecule CCC(CC)CNC(=O)N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1 to have a lower LogP value.,CCC(CC)CNC(=O)N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1,1.9324
223709,Please modify the molecule CC[C@H](O)c1ccn(C[C@@H]2Cc3cc(F)ccc3O2)c1 to decrease its LogP value.,CC[C@H](O)c1ccn(C[C@@H]2Cc3cc(F)ccc3O2)c1,3.074300000000002
56820,Modify the molecule COc1ccccc1[C@H]1C[C@@H]1C(=O)N[C@@H]1CCCC[C@@H]1C(F)(F)F to have a lower LogP value.,COc1ccccc1[C@H]1C[C@@H]1C(=O)N[C@@H]1CCCC[C@@H]1C(F)(F)F,4.036000000000003
201230,Please optimize the molecule C[C@@H]1C[C@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCOCC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCOCC1,0.4922000000000002
87270,Modify the molecule Nc1ccc(-n2cc(-c3cccc(Cl)c3)cn2)cc1 to have a lower LogP value.,Nc1ccc(-n2cc(-c3cccc(Cl)c3)cn2)cc1,3.7749000000000015
202136,Please modify the molecule CC[NH2+][C@H](Cc1cccnc1)[C@@H](C)CC to decrease its LogP value.,CC[NH2+][C@H](Cc1cccnc1)[C@@H](C)CC,1.6220999999999994
130805,Please modify the molecule C[C@H](NC(=O)C1(NS(C)(=O)=O)CCCCC1)C(=O)NC(C)(C)C to increase its LogP value.,C[C@H](NC(=O)C1(NS(C)(=O)=O)CCCCC1)C(=O)NC(C)(C)C,0.6578999999999997
211612,Modify the molecule CC[NH+](Cc1ccc2c(c1)CC(C)(C)O2)[C@@H](C)CS(C)(=O)=O to have a lower LogP value.,CC[NH+](Cc1ccc2c(c1)CC(C)(C)O2)[C@@H](C)CS(C)(=O)=O,1.2380000000000002
78527,Optimize the molecule C[C@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CC(=O)[O-] to have a lower LogP value.,C[C@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CC(=O)[O-],-0.067499999999999
179458,Optimize the molecule COc1ccc(CC(=O)NCCOc2cccc(C)c2)cc1F to have a higher LogP value.,COc1ccc(CC(=O)NCCOc2cccc(C)c2)cc1F,2.8804200000000018
142852,Modify the molecule COc1cc2c(cc1OC)[C@H](c1cccs1)N(C(=O)[C@H]1Cc3ccccc31)CC2 to have a higher LogP value.,COc1cc2c(cc1OC)[C@H](c1cccs1)N(C(=O)[C@H]1Cc3ccccc31)CC2,4.5793000000000035
160501,Optimize the molecule CC(=O)N(C)[C@H](c1ccc2c(c1)OCO2)c1nnnn1-c1ccc(C)cc1 to have a higher LogP value.,CC(=O)N(C)[C@H](c1ccc2c(c1)OCO2)c1nnnn1-c1ccc(C)cc1,2.2671200000000002
81663,Please modify the molecule CCCC[NH+](CCO)Cc1ncc(C)o1 to increase its LogP value.,CCCC[NH+](CCO)Cc1ncc(C)o1,0.16032000000000046
145014,Please modify the molecule COc1ccc(-c2nonc2NC(=O)COc2ccc(C)c(C)c2)cc1 to increase its LogP value.,COc1ccc(-c2nonc2NC(=O)COc2ccc(C)c(C)c2)cc1,3.379540000000002
194126,Modify the molecule CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H]1CCN(Cc2ccccn2)C[C@@H]1C to decrease its LogP value.,CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H]1CCN(Cc2ccccn2)C[C@@H]1C,2.4491000000000005
248241,Modify the molecule Cc1nn(CC(=O)N(C)[C@H](C)c2ccccc2)c(C)c1S(=O)(=O)N(C)C to have a higher LogP value.,Cc1nn(CC(=O)N(C)[C@H](C)c2ccccc2)c(C)c1S(=O)(=O)N(C)C,1.9698400000000003
62015,Modify the molecule C[C@H](C(=O)Nc1ncccn1)[NH+](C)Cc1ccccc1N1CCOCC1 to decrease its LogP value.,C[C@H](C(=O)Nc1ncccn1)[NH+](C)Cc1ccccc1N1CCOCC1,0.3551000000000015
74562,Modify the molecule O=C(NCc1cccnc1OC1CCCC1)c1ccc2c(c1)COCO2 to have a lower LogP value.,O=C(NCc1cccnc1OC1CCCC1)c1ccc2c(c1)COCO2,3.1995000000000022
15181,Please modify the molecule NC(=O)c1ccnc(N(CC(=O)[O-])CC(F)(F)F)c1 to increase its LogP value.,NC(=O)c1ccnc(N(CC(=O)[O-])CC(F)(F)F)c1,-0.7009000000000003
198677,Please optimize the molecule COC(=O)c1ccccc1S(=O)(=O)Nc1cc2c(cc1Cl)OCCO2 to have a higher LogP value.,COC(=O)c1ccccc1S(=O)(=O)Nc1cc2c(cc1Cl)OCCO2,2.6986000000000008
242873,Please modify the molecule CCn1cc(C(=O)N[C@@H]2CC3(CCCC3)Oc3ccccc32)c(C)n1 to increase its LogP value.,CCn1cc(C(=O)N[C@@H]2CC3(CCCC3)Oc3ccccc32)c(C)n1,3.777820000000003
210741,Please optimize the molecule Cc1nn(-c2ccccc2)cc1CN1CCN(CC#N)CC1 to have a lower LogP value.,Cc1nn(-c2ccccc2)cc1CN1CCN(CC#N)CC1,1.8218999999999999
44542,Optimize the molecule C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1ccc(OC(F)(F)F)cc1 to have a higher LogP value.,C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1ccc(OC(F)(F)F)cc1,1.4955
217635,Please modify the molecule CC(=O)c1ccc(OCC(=O)Nc2ccccc2C(C)C)cc1 to increase its LogP value.,CC(=O)c1ccc(OCC(=O)Nc2ccccc2C(C)C)cc1,4.030100000000003
53304,Please modify the molecule C[NH2+]C[C@@H](C)C(=O)Nc1ccc2c(c1)C(=O)NC2=O to decrease its LogP value.,C[NH2+]C[C@@H](C)C(=O)Nc1ccc2c(c1)C(=O)NC2=O,-0.661999999999999
213595,Modify the molecule CC[C@@H](C)NC(=O)C(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1 to increase its LogP value.,CC[C@@H](C)NC(=O)C(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1,1.5361000000000002
180477,Modify the molecule CCc1sc([C@H](C)[NH2+][C@@H](C)C2CC[NH+](C)CC2)cc1C to decrease its LogP value.,CCc1sc([C@H](C)[NH2+][C@@H](C)C2CC[NH+](C)CC2)cc1C,1.5565200000000008
198645,Please modify the molecule O=[N+]([O-])c1ccc(F)c(NCc2ncc(-c3cccs3)o2)c1 to decrease its LogP value.,O=[N+]([O-])c1ccc(F)c(NCc2ncc(-c3cccs3)o2)c1,4.062500000000002
108011,Modify the molecule O=C(CSc1ccccn1)N/N=C/c1cccc(I)c1 to have a lower LogP value.,O=C(CSc1ccccn1)N/N=C/c1cccc(I)c1,2.928600000000001
129223,Please optimize the molecule C[C@H]1C[C@@H](NC(=O)N(C)CC2CC2)CC[NH+]1Cc1ccccc1 to have a lower LogP value.,C[C@H]1C[C@@H](NC(=O)N(C)CC2CC2)CC[NH+]1Cc1ccccc1,1.6738000000000002
140271,Optimize the molecule C[C@@H](CNC(=O)c1cn(Cc2cccnc2)nn1)Cc1cccs1 to have a higher LogP value.,C[C@@H](CNC(=O)c1cn(Cc2cccnc2)nn1)Cc1cccs1,2.3915000000000006
222049,Modify the molecule COc1ccc(NC(=O)N[C@@H]2C[C@@H]2C)cc1OCC(F)(F)F to have a lower LogP value.,COc1ccc(NC(=O)N[C@@H]2C[C@@H]2C)cc1OCC(F)(F)F,3.1662000000000017
142403,Please optimize the molecule CC(=O)N1CC[C@H](NC(=O)Nc2cccc(CC[NH+]3CCCC3)c2)C1 to have a higher LogP value.,CC(=O)N1CC[C@H](NC(=O)Nc2cccc(CC[NH+]3CCCC3)c2)C1,0.6501000000000015
161587,Modify the molecule CCC1CCC(C[NH2+][C@H]2CCOC3(CCSCC3)C2)CC1 to decrease its LogP value.,CCC1CCC(C[NH2+][C@H]2CCOC3(CCSCC3)C2)CC1,3.211000000000001
117259,Optimize the molecule COCCOc1cc(C)ccc1NC(=O)[C@H]1CCOc2ccccc21 to have a higher LogP value.,COCCOc1cc(C)ccc1NC(=O)[C@H]1CCOc2ccccc21,3.5250200000000023
25059,Modify the molecule C#CC[C@H](OC(=O)CCn1cnc2c(C)cccc2c1=O)C1CC1 to decrease its LogP value.,C#CC[C@H](OC(=O)CCn1cnc2c(C)cccc2c1=O)C1CC1,2.4401200000000003
164968,Please modify the molecule O=C(NCc1nnc2n1CCCCC2)N[C@H]1C[C@H]2CCCc3cccc1c32 to decrease its LogP value.,O=C(NCc1nnc2n1CCCCC2)N[C@H]1C[C@H]2CCCc3cccc1c32,3.3686000000000016
132115,Please modify the molecule Cc1ccc2nc(NC(=O)c3nc(S(C)(=O)=O)ncc3Br)sc2c1 to decrease its LogP value.,Cc1ccc2nc(NC(=O)c3nc(S(C)(=O)=O)ncc3Br)sc2c1,2.8130200000000007
135724,Modify the molecule CCOCCCNC(=O)NCc1cc2ccccc2o1 to have a higher LogP value.,CCOCCCNC(=O)NCc1cc2ccccc2o1,2.6586000000000007
57623,Please optimize the molecule O=C(COc1ccccc1)N/N=C(/C=C/c1ccccc1)c1ccccc1 to have a higher LogP value.,O=C(COc1ccccc1)N/N=C(/C=C/c1ccccc1)c1ccccc1,4.299300000000003
26333,Modify the molecule CN(C)S(=O)(=O)N1CC[NH+](CCc2ccccc2C(F)(F)F)CC1 to have a higher LogP value.,CN(C)S(=O)(=O)N1CC[NH+](CCc2ccccc2C(F)(F)F)CC1,0.2548000000000028
172382,Modify the molecule CO[C@@H](C)[C@H]([NH3+])c1ccc(F)c(F)c1 to increase its LogP value.,CO[C@@H](C)[C@H]([NH3+])c1ccc(F)c(F)c1,1.2827000000000002
164543,Optimize the molecule N#Cc1nc(/C=C/c2cccc([N+](=O)[O-])c2)oc1N1CCN(C(=O)COc2ccccc2F)CC1 to have a lower LogP value.,N#Cc1nc(/C=C/c2cccc([N+](=O)[O-])c2)oc1N1CCN(C(=O)COc2ccccc2F)CC1,3.4915800000000026
66137,Modify the molecule C[C@H]1C[C@H](C)CN(C(=O)NC[C@@H](c2ccccc2)N2CCOCC2)C1 to have a higher LogP value.,C[C@H]1C[C@H](C)CN(C(=O)NC[C@@H](c2ccccc2)N2CCOCC2)C1,2.7474000000000007
91669,Optimize the molecule COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1 to have a lower LogP value.,COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1,0.04930000000000101
85889,Please modify the molecule CC(C)[C@H](CCO)NC(=O)c1ccc(-n2ccnn2)cc1 to decrease its LogP value.,CC(C)[C@H](CCO)NC(=O)c1ccc(-n2ccnn2)cc1,1.4041
159588,Please modify the molecule Cc1ccc(C)c(NC(=O)[C@H](c2ccccc2)N2CCN(C(=O)C3CC3)CC2)c1 to decrease its LogP value.,Cc1ccc(C)c(NC(=O)[C@H](c2ccccc2)N2CCN(C(=O)C3CC3)CC2)c1,3.537440000000002
27252,Please optimize the molecule COc1cccc(C(=O)N2C[C@H](O)C[C@H]2c2cc(F)ccc2F)n1 to have a lower LogP value.,COc1cccc(C(=O)N2C[C@H](O)C[C@H]2c2cc(F)ccc2F)n1,2.3165000000000004
155909,Modify the molecule O=C(NCc1ccccc1F)C(=O)Nc1ccccc1Br to have a higher LogP value.,O=C(NCc1ccccc1F)C(=O)Nc1ccccc1Br,2.8431000000000006
6708,Please optimize the molecule COC(=O)C[C@@H]1CCCCN1C(=O)c1cccnc1 to have a higher LogP value.,COC(=O)C[C@@H]1CCCCN1C(=O)c1cccnc1,1.6394
100269,Please modify the molecule O=S(=O)(/N=C1\N=c2ccccc2=[NH+][C@@H]1Nc1ccc2c(c1)OCO2)c1ccc(Cl)cc1 to increase its LogP value.,O=S(=O)(/N=C1\N=c2ccccc2=[NH+][C@@H]1Nc1ccc2c(c1)OCO2)c1ccc(Cl)cc1,0.6276999999999997
233824,Modify the molecule COc1ccccc1[C@@H]1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC[C@@H]1CCCO1)[C@@H]2c1ccccc1F to have a lower LogP value.,COc1ccccc1[C@@H]1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC[C@@H]1CCCO1)[C@@H]2c1ccccc1F,4.918100000000004
65576,Modify the molecule CCc1nc(CN2CCN(Cc3scnc3C)CC2)cs1 to have a higher LogP value.,CCc1nc(CN2CCN(Cc3scnc3C)CC2)cs1,2.788220000000001
221994,Please modify the molecule Cc1ccc(Cl)cc1NC(=O)COC(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)COC(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O,2.30532
218853,Optimize the molecule CNC(=O)NCC(=O)N1CCC(=Cc2ccccc2)CC1 to have a lower LogP value.,CNC(=O)NCC(=O)N1CCC(=Cc2ccccc2)CC1,1.6213999999999997
76706,Please optimize the molecule CCc1ccccc1N(CC(=O)N1CCN(C=O)CC1)S(C)(=O)=O to have a higher LogP value.,CCc1ccccc1N(CC(=O)N1CCN(C=O)CC1)S(C)(=O)=O,0.315600000000001
67369,Modify the molecule CCNC(=S)NNC(=O)c1cn(C)nc1C to have a lower LogP value.,CCNC(=S)NNC(=O)c1cn(C)nc1C,-0.14267999999999992
101058,Modify the molecule COc1cc(Br)c(CC(=O)NCC2CC2)cc1OC to have a lower LogP value.,COc1cc(Br)c(CC(=O)NCC2CC2)cc1OC,2.535
167852,Modify the molecule O=C(Cn1cnc2sccc2c1=O)N1N=C2/C(=C/c3ccco3)CCC[C@H]2[C@@H]1c1ccco1 to have a higher LogP value.,O=C(Cn1cnc2sccc2c1=O)N1N=C2/C(=C/c3ccco3)CCC[C@H]2[C@@H]1c1ccco1,4.467200000000004
138310,Modify the molecule CC(C)c1ccc2[nH+]c3c(cc2c1)CCN3 to have a lower LogP value.,CC(C)c1ccc2[nH+]c3c(cc2c1)CCN3,2.7453000000000003
43585,Please modify the molecule C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCc2c(F)ccc(F)c2C1 to increase its LogP value.,C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCc2c(F)ccc(F)c2C1,2.4003000000000005
61245,Modify the molecule CC[C@@H](C)NC(=O)c1snc(C(=O)NC(C)C)c1N to decrease its LogP value.,CC[C@@H](C)NC(=O)c1snc(C(=O)NC(C)C)c1N,1.3918000000000001
20093,Optimize the molecule O=C(NCc1ccccc1F)N1CCN(S(=O)(=O)c2ccccc2F)CC1 to have a lower LogP value.,O=C(NCc1ccccc1F)N1CCN(S(=O)(=O)c2ccccc2F)CC1,2.1809000000000003
189293,Modify the molecule NC(=O)NCC(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1 to increase its LogP value.,NC(=O)NCC(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1,1.8953
94726,Please optimize the molecule CC(=O)Nc1ccc(CC(=O)OCc2cc(=O)n3ccc(C)cc3n2)cc1 to have a lower LogP value.,CC(=O)Nc1ccc(CC(=O)OCc2cc(=O)n3ccc(C)cc3n2)cc1,2.2472199999999996
119851,Modify the molecule Nc1c(NCc2ccccc2)ncnc1Nc1ccccc1F to have a lower LogP value.,Nc1c(NCc2ccccc2)ncnc1Nc1ccccc1F,3.553600000000002
36210,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)CN2CC[NH+](Cc3cccc(C(F)(F)F)c3)CC2)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)CN2CC[NH+](Cc3cccc(C(F)(F)F)c3)CC2)C1,1.9104000000000003
43187,Optimize the molecule CCN(Cc1cc(=O)n(C)c(=O)n1C)[C@@H](C)c1cccc(OC)c1 to have a lower LogP value.,CCN(Cc1cc(=O)n(C)c(=O)n1C)[C@@H](C)c1cccc(OC)c1,1.6756999999999995
38943,Please modify the molecule O=C(c1ccc(Cl)cc1F)N1CCC(CCc2ccc(O)cc2)CC1 to decrease its LogP value.,O=C(c1ccc(Cl)cc1F)N1CCC(CCc2ccc(O)cc2)CC1,4.669700000000003
120509,Optimize the molecule FC(F)(F)c1cccc(OCCCCCS)c1 to have a lower LogP value.,FC(F)(F)c1cccc(OCCCCCS)c1,4.184300000000003
8975,Please optimize the molecule COC(=O)c1c(NC(=S)Nc2ccc3c(c2)CCC3)sc2c1CC[C@H](C)C2 to have a higher LogP value.,COC(=O)c1c(NC(=S)Nc2ccc3c(c2)CCC3)sc2c1CC[C@H](C)C2,4.957100000000004
12297,Please modify the molecule CN(C)C(=O)Sc1cccc(CN2C(=O)c3ccc(F)cc3C2=O)c1 to decrease its LogP value.,CN(C)C(=O)Sc1cccc(CN2C(=O)c3ccc(F)cc3C2=O)c1,3.3956000000000026
101501,Modify the molecule Cn1c(C(=O)NCC(=O)Nc2cccc(Cl)c2)cc2occc21 to increase its LogP value.,Cn1c(C(=O)NCC(=O)Nc2cccc(Cl)c2)cc2occc21,2.7932000000000006
8395,Optimize the molecule FC(F)(F)c1cccc(Nc2scc(-c3ccc(Cl)cc3)[n+]2CCc2ccccc2)c1 to have a higher LogP value.,FC(F)(F)c1cccc(Nc2scc(-c3ccc(Cl)cc3)[n+]2CCc2ccccc2)c1,7.361100000000005
143872,Optimize the molecule O=C(/C=C/c1ccccc1Cl)Nc1ccc([N+](=O)[O-])cn1 to have a lower LogP value.,O=C(/C=C/c1ccccc1Cl)Nc1ccc([N+](=O)[O-])cn1,3.2951000000000015
97860,Modify the molecule Cc1nc(-c2c[nH]c(C(=O)NCC3(c4cccc(F)c4)CCOCC3)c2)cs1 to have a higher LogP value.,Cc1nc(-c2c[nH]c(C(=O)NCC3(c4cccc(F)c4)CCOCC3)c2)cs1,4.063920000000003
78552,Modify the molecule CCCCN(C)C(=O)C(=O)Nc1cc(C(=O)NC(C)C)ccc1Cl to have a lower LogP value.,CCCCN(C)C(=O)C(=O)Nc1cc(C(=O)NC(C)C)ccc1Cl,2.6752000000000002
173219,Modify the molecule CCCn1/c(=N/C(=O)c2ccc[nH]c2=S)[nH]c2ccccc21 to increase its LogP value.,CCCn1/c(=N/C(=O)c2ccc[nH]c2=S)[nH]c2ccccc21,3.178090000000001
75597,Modify the molecule Cc1ccc(NCCC(=O)c2cccs2)cc1F to increase its LogP value.,Cc1ccc(NCCC(=O)c2cccs2)cc1F,3.8805200000000024
217173,Optimize the molecule COc1cc(Br)cc(CN2CCO[C@@H](c3nccs3)C2)c1O to have a higher LogP value.,COc1cc(Br)cc(CN2CCO[C@@H](c3nccs3)C2)c1O,3.193300000000002
233980,Modify the molecule CC(C)[NH2+]C[C@@H](C)[C@H](C)N(C)[C@@H](C)c1ccccc1F to decrease its LogP value.,CC(C)[NH2+]C[C@@H](C)[C@H](C)N(C)[C@@H](C)c1ccccc1F,2.8149000000000006
46384,Modify the molecule Cc1ncccc1OC1(C(=O)[O-])CCN(C(=O)c2ccc([O-])nn2)CC1 to decrease its LogP value.,Cc1ncccc1OC1(C(=O)[O-])CCN(C(=O)c2ccc([O-])nn2)CC1,-0.9426799999999995
119964,Modify the molecule O=C(NC1CC1)c1cccnc1Oc1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1 to increase its LogP value.,O=C(NC1CC1)c1cccnc1Oc1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1,4.875100000000003
240204,Please modify the molecule CCc1cc(N2CC[C@@H]([NH3+])C2)nc(Nc2ccccc2)n1 to increase its LogP value.,CCc1cc(N2CC[C@@H]([NH3+])C2)nc(Nc2ccccc2)n1,1.6031999999999993
165868,Modify the molecule Nc1nnc(SCC(=O)N2CCC(Cc3ccccc3)CC2)s1 to have a lower LogP value.,Nc1nnc(SCC(=O)N2CCC(Cc3ccccc3)CC2)s1,2.6937000000000006
140225,Please optimize the molecule CCN1CCC2=C(C1)C(=O)NC(=O)[C@@H]2C#N to have a higher LogP value.,CCN1CCC2=C(C1)C(=O)NC(=O)[C@@H]2C#N,-0.19522000000000012
45298,Optimize the molecule Cc1cc(C)n(CC2=NN=C(C(=O)NC[C@@H]3CCCCO3)C2)n1 to have a higher LogP value.,Cc1cc(C)n(CC2=NN=C(C(=O)NC[C@@H]3CCCCO3)C2)n1,1.3859399999999993
192809,Optimize the molecule C[C@H](NC(=O)c1ccncc1F)c1cccc(-n2cccn2)c1 to have a higher LogP value.,C[C@H](NC(=O)c1ccncc1F)c1cccc(-n2cccn2)c1,2.897400000000001
88033,Please optimize the molecule O=C(N[C@H](N1CCOCC1)C(Cl)(Cl)Cl)c1ccccc1 to have a higher LogP value.,O=C(N[C@H](N1CCOCC1)C(Cl)(Cl)Cl)c1ccccc1,2.4449000000000005
49898,Modify the molecule CCOc1ccc([C@H](O)C2([NH+]3CCCC3)CCCC2)cc1 to have a higher LogP value.,CCOc1ccc([C@H](O)C2([NH+]3CCCC3)CCCC2)cc1,2.110199999999999
210283,Please optimize the molecule COc1ccccc1[C@H](C)[NH2+][C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1OC to have a lower LogP value.,COc1ccccc1[C@H](C)[NH2+][C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1OC,1.9538999999999997
131485,Modify the molecule O[C@H]1CCCc2[nH]c3cc(F)c(F)c(F)c3c21 to decrease its LogP value.,O[C@H]1CCCc2[nH]c3cc(F)c(F)c(F)c3c21,2.954900000000001
183384,Optimize the molecule C[NH+]1CCC(CCNC(=O)C(=O)Nc2ccc(F)cc2F)CC1 to have a higher LogP value.,C[NH+]1CCC(CCNC(=O)C(=O)Nc2ccc(F)cc2F)CC1,0.3342999999999998
103722,Please optimize the molecule OCC[C@H]1CN(c2ncnc3c2CC[NH2+]CC3)CCN1Cc1ccoc1 to have a higher LogP value.,OCC[C@H]1CN(c2ncnc3c2CC[NH2+]CC3)CCN1Cc1ccoc1,-0.19519999999999738
33930,Modify the molecule CCOC(=O)c1cnc2ccc(Cl)nc2c1Cl to decrease its LogP value.,CCOC(=O)c1cnc2ccc(Cl)nc2c1Cl,3.1133000000000015
105853,Please modify the molecule COC[C@@H](NC(=O)Cc1c[nH]c2ccccc12)c1ccc(F)c(F)c1 to increase its LogP value.,COC[C@@H](NC(=O)Cc1c[nH]c2ccccc12)c1ccc(F)c(F)c1,3.4925000000000015
29417,Modify the molecule CC1=C[C@@H]([C@@H]2N=N[C@H](S)N2/N=C/c2ccc(C(=O)[O-])cc2)N=N1 to increase its LogP value.,CC1=C[C@@H]([C@@H]2N=N[C@H](S)N2/N=C/c2ccc(C(=O)[O-])cc2)N=N1,1.4295
19528,Please modify the molecule CC1=N[C@@H](CNC(=O)[C@H]2C=C(C[NH+](C)Cc3ccccc3)ON2)N=C1 to decrease its LogP value.,CC1=N[C@@H](CNC(=O)[C@H]2C=C(C[NH+](C)Cc3ccccc3)ON2)N=C1,-0.5237999999999967
196139,Modify the molecule Cc1cc(C[NH+]2CCN(C(=O)c3oc4ccc(Cl)cc4c3C)CC2)no1 to increase its LogP value.,Cc1cc(C[NH+]2CCN(C(=O)c3oc4ccc(Cl)cc4c3C)CC2)no1,2.23194
217273,Please modify the molecule Nn1c(SCC(=O)Nc2cc(Cl)cc(Cl)c2)nnc1C(F)(F)F to decrease its LogP value.,Nn1c(SCC(=O)Nc2cc(Cl)cc(Cl)c2)nnc1C(F)(F)F,3.048300000000001
69070,Optimize the molecule CN(C)[C@H](CNC(=O)c1cccc(S(C)(=O)=O)c1)c1cccs1 to have a higher LogP value.,CN(C)[C@H](CNC(=O)c1cccc(S(C)(=O)=O)c1)c1cccs1,2.1842999999999995
133791,Modify the molecule COc1cccc(NC(=O)/C(C#N)=C/c2ccc(C)o2)c1 to have a lower LogP value.,COc1cccc(NC(=O)/C(C#N)=C/c2ccc(C)o2)c1,3.1423000000000014
247532,Please optimize the molecule N#Cc1cc(-c2ccccc2)oc1/N=C/c1ccc(Cl)cc1 to have a higher LogP value.,N#Cc1cc(-c2ccccc2)oc1/N=C/c1ccc(Cl)cc1,5.222280000000003
67743,Modify the molecule O=C(Nc1ccccc1)c1nnc(C(=O)N2CCC[C@@H](C(=O)N3CCCC3)C2)s1 to have a lower LogP value.,O=C(Nc1ccccc1)c1nnc(C(=O)N2CCC[C@@H](C(=O)N3CCCC3)C2)s1,2.2650000000000006
88590,Please optimize the molecule C[NH+]1CCC[C@]2(CC1)CNC(=[NH2+])N2c1ccccc1F to have a higher LogP value.,C[NH+]1CCC[C@]2(CC1)CNC(=[NH2+])N2c1ccccc1F,-1.2121999999999966
199167,Please modify the molecule O=C1C[C@@H](c2cc([N+](=O)[O-])ccc2Cl)c2cc3c(cc2N1)OCO3 to increase its LogP value.,O=C1C[C@@H](c2cc([N+](=O)[O-])ccc2Cl)c2cc3c(cc2N1)OCO3,3.4510000000000014
21819,Modify the molecule CCOC(=O)/C=C/c1ccc(NC(=O)N[C@@H](C)[C@H]2CCCO2)cc1 to have a higher LogP value.,CCOC(=O)/C=C/c1ccc(NC(=O)N[C@@H](C)[C@H]2CCCO2)cc1,2.951900000000001
158646,Optimize the molecule NNC(=O)[C@@H]1CCCN(C(=O)COc2ccc(-c3ccccc3)cc2)C1 to have a lower LogP value.,NNC(=O)[C@@H]1CCCN(C(=O)COc2ccc(-c3ccccc3)cc2)C1,1.9608999999999996
15159,Modify the molecule Cc1cccc(Nc2ncnc(N(C)C)c2[N+](=O)[O-])c1C to have a higher LogP value.,Cc1cccc(Nc2ncnc(N(C)C)c2[N+](=O)[O-])c1C,2.8112400000000006
90965,Optimize the molecule O=C(CCNS(=O)(=O)c1ccc2ccccc2c1)Nc1ccc(F)cc1 to have a higher LogP value.,O=C(CCNS(=O)(=O)c1ccc2ccccc2c1)Nc1ccc(F)cc1,3.2860000000000014
147707,Please optimize the molecule Cc1ccc(OC[C@@H](O)C[NH+](C)Cc2cc(C)on2)c(C)c1 to have a higher LogP value.,Cc1ccc(OC[C@@H](O)C[NH+](C)Cc2cc(C)on2)c(C)c1,1.0544600000000002
113034,Please optimize the molecule O=C(c1cc[nH]n1)N1CCC2(CC1)c1ccccc1[C@@H]([NH+]1CCCCC1)[C@@H]2O to have a lower LogP value.,O=C(c1cc[nH]n1)N1CCC2(CC1)c1ccccc1[C@@H]([NH+]1CCCCC1)[C@@H]2O,1.0680999999999998
163237,Please optimize the molecule Cc1nc(Br)ccc1NC(=O)N1CCN(C(=O)CO)CC1 to have a lower LogP value.,Cc1nc(Br)ccc1NC(=O)N1CCN(C(=O)CO)CC1,0.8209199999999996
158217,Modify the molecule CC(C)C[C@@H](C[NH3+])c1nc2ccccc2n1CC(F)(F)F to decrease its LogP value.,CC(C)C[C@@H](C[NH3+])c1nc2ccccc2n1CC(F)(F)F,2.970200000000001
60889,Optimize the molecule C[C@H]1C[C@H]([NH3+])CN(Cc2cc(F)ccc2Br)C1 to have a higher LogP value.,C[C@H]1C[C@H]([NH3+])CN(Cc2cc(F)ccc2Br)C1,2.0404999999999998
30041,Please optimize the molecule Cc1ccc([C@](C)([NH3+])CCC(C)C)cc1F to have a lower LogP value.,Cc1ccc([C@](C)([NH3+])CCC(C)C)cc1F,3.027420000000001
164422,Modify the molecule COc1cc2c(cc1OC)[C@@H](CC(=O)[O-])N(C(=O)Nc1ccc(Cl)cc1)CC2 to decrease its LogP value.,COc1cc2c(cc1OC)[C@@H](CC(=O)[O-])N(C(=O)Nc1ccc(Cl)cc1)CC2,2.6285000000000007
44048,Optimize the molecule CC[C@H](C)N(C)C(=O)c1c(O)cc(F)cc1F to have a lower LogP value.,CC[C@H](C)N(C)C(=O)c1c(O)cc(F)cc1F,2.5409000000000006
222453,Optimize the molecule C[C@H](CCc1cccn1C)NC(=O)N[C@H]1CCC[C@@H]1CO to have a higher LogP value.,C[C@H](CCc1cccn1C)NC(=O)N[C@H]1CCC[C@@H]1CO,1.8063999999999996
8378,Optimize the molecule C=CCNC(=O)N(Cc1ccsc1)C1CC1 to have a higher LogP value.,C=CCNC(=O)N(Cc1ccsc1)C1CC1,2.608100000000001
178808,Please optimize the molecule Cc1ccc(OCC(=O)N(C)CCS(C)(=O)=O)cc1C to have a lower LogP value.,Cc1ccc(OCC(=O)N(C)CCS(C)(=O)=O)cc1C,1.18524
158187,Modify the molecule Cc1cc(CNC(=O)c2cc(C)sc2NC(=O)C(C)(C)C)[nH]n1 to increase its LogP value.,Cc1cc(CNC(=O)c2cc(C)sc2NC(=O)C(C)(C)C)[nH]n1,3.0026400000000013
34624,Please modify the molecule CC(C)(O)CNC(=O)[C@H]1C=C[C@@H]([NH3+])C1 to decrease its LogP value.,CC(C)(O)CNC(=O)[C@H]1C=C[C@@H]([NH3+])C1,-0.9398999999999988
133352,Optimize the molecule CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1 to have a lower LogP value.,CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1,3.0135000000000014
91038,Modify the molecule CCCn1nnnc1COc1ccnc2cc(OC)ccc12 to have a lower LogP value.,CCCn1nnnc1COc1ccnc2cc(OC)ccc12,2.2188999999999997
196513,Optimize the molecule C[C@H](CCO)NC(=O)N[C@H](c1cccnc1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,C[C@H](CCO)NC(=O)N[C@H](c1cccnc1)c1cccc(C(F)(F)F)c1,3.259900000000002
109637,Modify the molecule O=S(=O)(NCC1CCN(c2nsc3ccccc23)CC1)c1ccccc1F to have a lower LogP value.,O=S(=O)(NCC1CCN(c2nsc3ccccc23)CC1)c1ccccc1F,3.6303000000000027
54994,Modify the molecule C[C@H](NC(=O)N(C)CCc1ccc(F)cc1)c1cccc(-n2cccn2)c1 to decrease its LogP value.,C[C@H](NC(=O)N(C)CCc1ccc(F)cc1)c1cccc(-n2cccn2)c1,3.956500000000003
80570,Please optimize the molecule C=CCn1c(SCC(=O)c2ccc(C#N)cc2)nc2ccccc2c1=O to have a higher LogP value.,C=CCn1c(SCC(=O)c2ccc(C#N)cc2)nc2ccccc2c1=O,3.4291800000000023
97472,Modify the molecule O=S1(=O)CC[C@@](O)([C@@H]2CCOC3(CCCC3)C2)C1 to have a lower LogP value.,O=S1(=O)CC[C@@](O)([C@@H]2CCOC3(CCCC3)C2)C1,1.2753999999999999
24052,Modify the molecule CC[C@@](C)([C@H]([NH3+])CCC1CC1)N1CCOCC1 to decrease its LogP value.,CC[C@@](C)([C@H]([NH3+])CCC1CC1)N1CCOCC1,1.2880000000000007
231616,Please optimize the molecule N#C/C(=C/c1cccn1-c1ccc(C(=O)[O-])cc1)C(=O)Nc1ccc(O)cc1 to have a higher LogP value.,N#C/C(=C/c1cccn1-c1ccc(C(=O)[O-])cc1)C(=O)Nc1ccc(O)cc1,2.0920799999999993
70154,Optimize the molecule C[C@H](NC(=O)Nc1ccc(N(C)C)cc1)c1cc2ccccc2o1 to have a lower LogP value.,C[C@H](NC(=O)Nc1ccc(N(C)C)cc1)c1cc2ccccc2o1,4.381500000000003
39885,Please optimize the molecule C=CCOc1c(Br)cc(/C=C(/C#N)C(=O)N(C)C)cc1I to have a lower LogP value.,C=CCOc1c(Br)cc(/C=C(/C#N)C(=O)N(C)C)cc1I,3.613680000000003
155074,Modify the molecule O=C(c1cc(-c2ccccc2)on1)N1CC[C@H](c2ccccn2)C1 to increase its LogP value.,O=C(c1cc(-c2ccccc2)on1)N1CC[C@H](c2ccccn2)C1,3.3663000000000016
223963,Modify the molecule COc1ccc(N[C@@H](c2ccc(Cl)cc2)c2nnc(-c3ccccc3)o2)cc1OC to have a lower LogP value.,COc1ccc(N[C@@H](c2ccc(Cl)cc2)c2nnc(-c3ccccc3)o2)cc1OC,5.608700000000005
241363,Please modify the molecule C[C@@H](C(=O)Nc1ccccc1C#N)[NH+]1CCN(c2cccc(Cl)c2)CC1 to decrease its LogP value.,C[C@@H](C(=O)Nc1ccccc1C#N)[NH+]1CCN(c2cccc(Cl)c2)CC1,1.9437799999999996
84372,Modify the molecule O=C(CCc1nc(-c2ccc(Cl)cc2)no1)Nc1cccc(Oc2cnccn2)c1 to increase its LogP value.,O=C(CCc1nc(-c2ccc(Cl)cc2)no1)Nc1cccc(Oc2cnccn2)c1,4.543600000000003
881,Modify the molecule COc1c(C)cnc(CNC(=O)Nc2ccc(N(C)C)cc2)c1C to decrease its LogP value.,COc1c(C)cnc(CNC(=O)Nc2ccc(N(C)C)cc2)c1C,3.0947400000000016
230264,Modify the molecule CS(=O)(=O)Cc1ccc(C(=O)Nc2nc[nH]n2)cc1 to decrease its LogP value.,CS(=O)(=O)Cc1ccc(C(=O)Nc2nc[nH]n2)cc1,0.6015999999999998
192739,Please optimize the molecule Cc1ccc(F)cc1C(=O)NCCCCN1C[C@@H](C)O[C@H](C)C1 to have a lower LogP value.,Cc1ccc(F)cc1C(=O)NCCCCN1C[C@@H](C)O[C@H](C)C1,2.7533200000000013
72883,Please modify the molecule Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O to decrease its LogP value.,Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O,0.9193199999999999
49621,Optimize the molecule O=C(c1ccc2c(c1)OCCO2)C1CC[NH+](CCCO)CC1 to have a higher LogP value.,O=C(c1ccc2c(c1)OCCO2)C1CC[NH+](CCCO)CC1,0.3178000000000006
157859,Modify the molecule Cc1ccccc1NCN1C(=O)S/C(=C\c2ccc(N(C)C)cc2)C1=O to decrease its LogP value.,Cc1ccccc1NCN1C(=O)S/C(=C\c2ccc(N(C)C)cc2)C1=O,4.166920000000003
247108,Optimize the molecule COc1ccc([C@H]2c3c(C)n[nH]c3Nc3[nH]c(=O)[nH]c(=O)c32)c(OC)c1 to have a lower LogP value.,COc1ccc([C@H]2c3c(C)n[nH]c3Nc3[nH]c(=O)[nH]c(=O)c32)c(OC)c1,1.3491199999999999
199870,Modify the molecule NC1=[NH+]C[C@@H]([C@@H]2CCCOC2)N1c1ccc(F)cc1 to have a higher LogP value.,NC1=[NH+]C[C@@H]([C@@H]2CCCOC2)N1c1ccc(F)cc1,-0.16379999999999995
88345,Please modify the molecule Cc1ccc(NC(=O)/C=C/C2CC2)cc1NC(=O)c1ccncc1 to decrease its LogP value.,Cc1ccc(NC(=O)/C=C/C2CC2)cc1NC(=O)c1ccncc1,3.5470200000000016
71097,Please modify the molecule CN1C(=O)Cc2cc([C@H]([NH3+])c3ccccc3F)ccc21 to increase its LogP value.,CN1C(=O)Cc2cc([C@H]([NH3+])c3ccccc3F)ccc21,1.6758999999999997
195839,Optimize the molecule CS[C@H](C)C(=O)NCc1csc(Br)c1 to have a higher LogP value.,CS[C@H](C)C(=O)NCc1csc(Br)c1,2.878300000000001
165348,Please optimize the molecule CC(CO)(CO)C[C@H]1Cc2ccccc2O1 to have a lower LogP value.,CC(CO)(CO)C[C@H]1Cc2ccccc2O1,1.3711
244438,Please optimize the molecule CC[C@](C)([NH2+]CCC(=O)Nc1ccccc1)C(=O)[O-] to have a lower LogP value.,CC[C@](C)([NH2+]CCC(=O)Nc1ccccc1)C(=O)[O-],-0.502799999999999
146843,Please optimize the molecule Cc1cccc(NC(=O)Cn2nc(-c3ccccc3)nc2-c2ccccc2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)Cn2nc(-c3ccccc3)nc2-c2ccccc2)c1,4.559220000000003
204296,Modify the molecule COC(=O)c1ccc(CSc2nnc(N)n2C(C)C)o1 to decrease its LogP value.,COC(=O)c1ccc(CSc2nnc(N)n2C(C)C)o1,2.1130999999999998
1765,Modify the molecule Cc1cc(OC(=O)Cc2cccs2)cc2c1C(=O)/C(=C/c1ccccn1)O2 to increase its LogP value.,Cc1cc(OC(=O)Cc2cccs2)cc2c1C(=O)/C(=C/c1ccccn1)O2,4.2158200000000035
150897,Optimize the molecule Cc1nc(Cc2ccccc2)sc1[C@@H](C)[NH2+]C[C@H]1CC[C@H](C(N)=O)O1 to have a lower LogP value.,Cc1nc(Cc2ccccc2)sc1[C@@H](C)[NH2+]C[C@H]1CC[C@H](C(N)=O)O1,1.69962
245815,Optimize the molecule Nc1cncc(-c2nc3ccc(F)cc3s2)c1 to have a higher LogP value.,Nc1cncc(-c2nc3ccc(F)cc3s2)c1,3.079600000000001
161103,Modify the molecule NC(=O)c1ccc(Cn2cc(C(F)(F)F)ccc2=O)c([N+](=O)[O-])c1 to decrease its LogP value.,NC(=O)c1ccc(Cn2cc(C(F)(F)F)ccc2=O)c([N+](=O)[O-])c1,1.9224999999999999
226564,Please modify the molecule O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1 to decrease its LogP value.,O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1,-0.6537999999999993
26242,Modify the molecule Cc1nc(COC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)sc1C to increase its LogP value.,Cc1nc(COC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)sc1C,3.1408400000000016
85738,Modify the molecule C[C@H]1C(=O)N[C@@H](C(C)(C)C)C(=O)N1CC1C(C)(C)C1(C)C to decrease its LogP value.,C[C@H]1C(=O)N[C@@H](C(C)(C)C)C(=O)N1CC1C(C)(C)C1(C)C,2.4302
231335,Modify the molecule CN(Cc1cnn(C)c1)C(=O)CN1CCN(C(=O)NC2CCCCC2)CC1 to decrease its LogP value.,CN(Cc1cnn(C)c1)C(=O)CN1CCN(C(=O)NC2CCCCC2)CC1,1.0384000000000013
69009,Modify the molecule COCCN(C(=O)c1cccc2c1OCCO2)c1ccncc1 to decrease its LogP value.,COCCN(C(=O)c1cccc2c1OCCO2)c1ccncc1,2.146000000000001
119855,Please optimize the molecule COc1ccc(CC[C@]2(C)NC(=O)N(Cc3ncc(-c4ccccc4)o3)C2=O)cc1 to have a higher LogP value.,COc1ccc(CC[C@]2(C)NC(=O)N(Cc3ncc(-c4ccccc4)o3)C2=O)cc1,3.7935000000000025
139649,Please optimize the molecule Cc1ccnc2c1nc([C@@H](C)Cl)n2Cc1ccccc1 to have a higher LogP value.,Cc1ccnc2c1nc([C@@H](C)Cl)n2Cc1ccccc1,4.0878200000000025
195495,Modify the molecule O=C1NC(=O)/C(=C/c2ccc(F)cc2F)S1 to have a lower LogP value.,O=C1NC(=O)/C(=C/c2ccc(F)cc2F)S1,2.2887000000000004
194472,Optimize the molecule O=c1c2ccccc2nnn1COc1cccc(Cl)c1 to have a lower LogP value.,O=c1c2ccccc2nnn1COc1cccc(Cl)c1,2.4814
29598,Modify the molecule CN(CC(=O)NC[C@H](O)c1c(F)cccc1F)C(=O)c1cccs1 to increase its LogP value.,CN(CC(=O)NC[C@H](O)c1c(F)cccc1F)C(=O)c1cccs1,1.9480999999999997
50005,Optimize the molecule C=CCNC(=O)[C@@H](C)OC(=O)c1ccc2c(c1)OCCO2 to have a lower LogP value.,C=CCNC(=O)[C@@H](C)OC(=O)c1ccc2c(c1)OCCO2,1.3052999999999997
7996,Optimize the molecule CNC(=O)C1=NN=C2NC(=O)C[C@H]([C@@H]3C=NN=C3C3CCCCC3)[C@H]21 to have a lower LogP value.,CNC(=O)C1=NN=C2NC(=O)C[C@H]([C@@H]3C=NN=C3C3CCCCC3)[C@H]21,0.8896999999999995
4530,Modify the molecule O=C([O-])[C@@H]1C[C@@H](O)CN1C(=O)c1ccccc1 to decrease its LogP value.,O=C([O-])[C@@H]1C[C@@H](O)CN1C(=O)c1ccccc1,-0.9880999999999995
143242,Please modify the molecule Cc1ccc([C@H]2[C@H](C(=O)N3CCN(c4ccc(Cl)cc4)CC3)OCC(=O)N2C)cc1 to increase its LogP value.,Cc1ccc([C@H]2[C@H](C(=O)N3CCN(c4ccc(Cl)cc4)CC3)OCC(=O)N2C)cc1,2.895520000000001
135875,Modify the molecule CCNC(=O)NNC(=O)C[NH+]1CCC[C@@H]1C to have a higher LogP value.,CCNC(=O)NNC(=O)C[NH+]1CCC[C@@H]1C,-1.5960999999999972
144562,Please optimize the molecule CCCC(=O)Oc1ccc([C@H]2NC(=O)c3ccccc3O2)cc1 to have a lower LogP value.,CCCC(=O)Oc1ccc([C@H]2NC(=O)c3ccccc3O2)cc1,3.2131000000000016
130304,Modify the molecule CCn1nc(C)c(C[NH+]2CCC[C@@H](CNC(=O)c3ccccc3)C2)c1C to have a higher LogP value.,CCn1nc(C)c(C[NH+]2CCC[C@@H](CNC(=O)c3ccccc3)C2)c1C,1.7447400000000004
232758,Optimize the molecule COc1cc2c(cc1OC)CN(CN1C(=O)N[C@]3(CCCC[C@@H]3C)C1=O)CC2 to have a lower LogP value.,COc1cc2c(cc1OC)CN(CN1C(=O)N[C@]3(CCCC[C@@H]3C)C1=O)CC2,2.5201000000000002
133673,Optimize the molecule O=C(NCCC1CCN(c2cc[nH+]cc2)CC1)NC[C@]1(O)CCSC1 to have a higher LogP value.,O=C(NCCC1CCN(c2cc[nH+]cc2)CC1)NC[C@]1(O)CCSC1,1.2744
224283,Please optimize the molecule C[C@H](NC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccccc1 to have a higher LogP value.,C[C@H](NC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccccc1,3.2811000000000012
197292,Please modify the molecule O=c1cn[nH]c(N/N=C/c2ccc(O)cc2)n1 to decrease its LogP value.,O=c1cn[nH]c(N/N=C/c2ccc(O)cc2)n1,0.3164999999999997
161643,Optimize the molecule C[C@@H]1C[C@H]1c1ccc(CN(Cc2ccco2)C(=O)c2cccc([N+](=O)[O-])c2)o1 to have a lower LogP value.,C[C@@H]1C[C@H]1c1ccc(CN(Cc2ccco2)C(=O)c2cccc([N+](=O)[O-])c2)o1,4.746800000000005
9167,Modify the molecule CCn1cc([C@H]2C[C@@H](C(=O)Nc3ccc(Cl)cc3Cl)N(C)S(=O)(=O)N2)c(C)n1 to increase its LogP value.,CCn1cc([C@H]2C[C@@H](C(=O)Nc3ccc(Cl)cc3Cl)N(C)S(=O)(=O)N2)c(C)n1,2.7365200000000005
162557,Modify the molecule Cc1ccc(C(=O)c2ccccc2C(=O)NCc2nnc3n2CCCCC3)cc1 to have a higher LogP value.,Cc1ccc(C(=O)c2ccccc2C(=O)NCc2nnc3n2CCCCC3)cc1,3.4739200000000023
18518,Optimize the molecule COc1cc([C@H](C)NC(=O)N2CC[C@H](C)C2)cc(OC)c1OC to have a higher LogP value.,COc1cc([C@H](C)NC(=O)N2CC[C@H](C)C2)cc(OC)c1OC,2.8248000000000015
10631,Please modify the molecule Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1 to decrease its LogP value.,Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1,1.0851400000000004
61220,Modify the molecule O=c1ccc2c([nH]1)CCC[C@H]2[NH2+]C[C@@H]1C[C@H]1c1ccc(Cl)cc1Cl to decrease its LogP value.,O=c1ccc2c([nH]1)CCC[C@H]2[NH2+]C[C@@H]1C[C@H]1c1ccc(Cl)cc1Cl,3.4262000000000015
125301,Modify the molecule Cc1cc(/C=C2\C(=O)N(C)C(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccc(Cl)c1 to decrease its LogP value.,Cc1cc(/C=C2\C(=O)N(C)C(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccc(Cl)c1,4.756140000000005
130766,Optimize the molecule C[C@@H](CNC(=O)Nc1cncc2ccccc12)[S@](C)=O to have a lower LogP value.,C[C@@H](CNC(=O)Nc1cncc2ccccc12)[S@](C)=O,2.1233000000000004
202463,Modify the molecule COc1ccc(C[NH+]2CCN(c3ccc(Cl)cc3N)CC2)cc1 to decrease its LogP value.,COc1ccc(C[NH+]2CCN(c3ccc(Cl)cc3N)CC2)cc1,1.8359
5875,Modify the molecule CCc1noc(CC)c1CNC(=O)[C@@H]1Cc2cccc(F)c2O1 to have a higher LogP value.,CCc1noc(CC)c1CNC(=O)[C@@H]1Cc2cccc(F)c2O1,2.5584000000000007
193685,Modify the molecule Cc1cccc(-n2nnnc2SCC(=O)Nc2cccc(Cl)c2C)c1 to increase its LogP value.,Cc1cccc(-n2nnnc2SCC(=O)Nc2cccc(Cl)c2C)c1,3.6633400000000025
143578,Please optimize the molecule CCc1ccccc1Nc1nc(N)nc(CN(C)C[C@H]2COc3ccccc3O2)n1 to have a higher LogP value.,CCc1ccccc1Nc1nc(N)nc(CN(C)C[C@H]2COc3ccccc3O2)n1,3.031600000000001
161979,Modify the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1 to increase its LogP value.,C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1,3.1054000000000013
30814,Please optimize the molecule COc1ccccc1[C@@H]1CCCN1C(=O)NCCN1CCOCC1 to have a higher LogP value.,COc1ccccc1[C@@H]1CCCN1C(=O)NCCN1CCOCC1,1.8739
124124,Optimize the molecule CC(C)CC(=O)Nc1cccc(CNC(=O)N2CCOCC[C@H]2C)c1 to have a lower LogP value.,CC(C)CC(=O)Nc1cccc(CNC(=O)N2CCOCC[C@H]2C)c1,2.991600000000002
193238,Please modify the molecule C[C@@H](NC(=O)CCn1cnc2sccc2c1=O)c1ccc(Cl)cc1 to decrease its LogP value.,C[C@@H](NC(=O)CCn1cnc2sccc2c1=O)c1ccc(Cl)cc1,3.3789000000000016
51535,Modify the molecule COc1ccc(Cl)cc1-n1nnc(C(=O)NCc2ccccc2Cl)c1C to have a lower LogP value.,COc1ccc(Cl)cc1-n1nnc(C(=O)NCc2ccccc2Cl)c1C,3.8211200000000023
153527,Modify the molecule CCOC(=O)c1c(NC(=O)Cn2nc(C)cc2C)sc(C)c1C to decrease its LogP value.,CCOC(=O)c1c(NC(=O)Cn2nc(C)cc2C)sc(C)c1C,2.9936800000000012
121371,Please modify the molecule Cn1nc(C(=O)Cl)cc1-c1ccccc1 to decrease its LogP value.,Cn1nc(C(=O)Cl)cc1-c1ccccc1,2.4661
7217,Please modify the molecule C[C@@H](NC(=O)N(C)C[C@@H]1CCOC1)C(C)(C)C[NH+](C)C to increase its LogP value.,C[C@@H](NC(=O)N(C)C[C@@H]1CCOC1)C(C)(C)C[NH+](C)C,0.22350000000000292
25991,Modify the molecule CCNC(=O)c1ccc(CNC(=O)N[C@@H]2CCCC2(C)C)cc1 to have a higher LogP value.,CCNC(=O)c1ccc(CNC(=O)N[C@@H]2CCCC2(C)C)cc1,2.8142000000000014
226530,Modify the molecule Cc1ccc[nH+]c1NCCNC(=O)C[C@@H]1C(=O)NCC[NH+]1C1CCCC1 to have a higher LogP value.,Cc1ccc[nH+]c1NCCNC(=O)C[C@@H]1C(=O)NCC[NH+]1C1CCCC1,-0.9467799999999962
107557,Modify the molecule CC[NH2+][C@@H](c1ccc(OC)c(Br)c1)[C@@]1(C)CCCO1 to have a higher LogP value.,CC[NH2+][C@@H](c1ccc(OC)c(Br)c1)[C@@]1(C)CCCO1,2.651200000000001
226383,Modify the molecule C[C@@H](CNC(=O)c1cccc(NC(=O)C2CC2)c1)Oc1ccc(F)cc1 to have a lower LogP value.,C[C@@H](CNC(=O)c1cccc(NC(=O)C2CC2)c1)Oc1ccc(F)cc1,3.371500000000002
224885,Please optimize the molecule CC[C@@](C)(Nc1ccccc1Br)C(=O)[O-] to have a lower LogP value.,CC[C@@](C)(Nc1ccccc1Br)C(=O)[O-],1.7795999999999996
220382,Modify the molecule COc1ccc(C(=O)N(C)Cc2ccc(OC(F)F)cc2)cc1[N+](=O)[O-] to have a lower LogP value.,COc1ccc(C(=O)N(C)Cc2ccc(OC(F)F)cc2)cc1[N+](=O)[O-],3.477000000000002
196350,Please modify the molecule c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1 to decrease its LogP value.,c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1,0.31000000000000094
114659,Please modify the molecule O=C(NC(=S)Nc1ccc2oc(-c3ccccc3F)nc2c1)c1cccc(Cl)c1 to increase its LogP value.,O=C(NC(=S)Nc1ccc2oc(-c3ccccc3F)nc2c1)c1cccc(Cl)c1,5.414100000000002
224724,Modify the molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1 to have a higher LogP value.,CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,2.7878000000000016
160485,Please modify the molecule COc1cc(CNc2ccc(N3CCCC3=O)cn2)ccc1F to increase its LogP value.,COc1cc(CNc2ccc(N3CCCC3=O)cn2)ccc1F,2.9682000000000013
69645,Please modify the molecule CCCC[NH+](CC)Cc1ccc2c(c1)COC2 to decrease its LogP value.,CCCC[NH+](CC)Cc1ccc2c(c1)COC2,1.9217000000000002
123516,Modify the molecule C=CCN(C(=O)c1ccc2ccccc2n1)c1nc2c(s1)CCCC2 to increase its LogP value.,C=CCN(C(=O)c1ccc2ccccc2n1)c1nc2c(s1)CCCC2,4.402900000000003
159539,Modify the molecule CCn1nnc(NCc2ccc(-c3ccc(C)c(Cl)c3)o2)n1 to have a lower LogP value.,CCn1nnc(NCc2ccc(-c3ccc(C)c(Cl)c3)o2)n1,3.5269200000000023
74325,Please optimize the molecule Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1 to have a lower LogP value.,Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1,3.160700000000001
115463,Please modify the molecule CCCCn1nnnc1Cn1cnc2sc(-c3ccccc3)cc2c1=O to decrease its LogP value.,CCCCn1nnnc1Cn1cnc2sc(-c3ccccc3)cc2c1=O,2.959900000000001
91136,Optimize the molecule Cc1cccc(NC(=O)N[C@H]2CCC3(C2)OCCO3)c1Cl to have a higher LogP value.,Cc1cccc(NC(=O)N[C@H]2CCC3(C2)OCCO3)c1Cl,3.065520000000001
109539,Modify the molecule CC[C@H](NC(=O)c1cc(CC(C)C)n[nH]1)c1c(C)nn(C)c1C to increase its LogP value.,CC[C@H](NC(=O)c1cc(CC(C)C)n[nH]1)c1c(C)nn(C)c1C,2.839640000000001
80996,Modify the molecule Cc1ccn(C)c(=O)c1NC(=O)C(=O)NC[C@H](CC(C)C)[NH+](C)C to decrease its LogP value.,Cc1ccn(C)c(=O)c1NC(=O)C(=O)NC[C@H](CC(C)C)[NH+](C)C,-0.6923799999999967
224908,Please modify the molecule CN1C(=O)C[C@@H](NC(=O)C(=O)Nc2ccccc2)[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CN1C(=O)C[C@@H](NC(=O)C(=O)Nc2ccccc2)[C@@H]1c1ccc(Cl)cc1,2.3667
71819,Optimize the molecule N#Cc1ccc(C[NH+]2C[C@H]3CCCC[C@@H]3C2)o1 to have a higher LogP value.,N#Cc1ccc(C[NH+]2C[C@H]3CCCC[C@@H]3C2)o1,1.3561799999999995
202528,Modify the molecule Cc1cc([C@H](O)[C@H](C)C(C)C)c(F)cc1F to have a higher LogP value.,Cc1cc([C@H](O)[C@H](C)C(C)C)c(F)cc1F,3.598720000000003
84920,Modify the molecule C=CCOc1cccc([C@@H]2SCC(O)=Nc3n[nH]cc32)c1 to decrease its LogP value.,C=CCOc1cccc([C@@H]2SCC(O)=Nc3n[nH]cc32)c1,3.3987000000000016
144355,Please modify the molecule CCNC(=O)[C@@H](C)NC(=O)c1ccc([N+](=O)[O-])c(C)c1 to increase its LogP value.,CCNC(=O)[C@@H](C)NC(=O)c1ccc([N+](=O)[O-])c(C)c1,1.1576199999999999
206725,Please optimize the molecule CC[C@@H]1CCC[C@H](NC(=O)N2CCCN(c3ncccc3C#N)CC2)C1 to have a lower LogP value.,CC[C@@H]1CCC[C@H](NC(=O)N2CCCN(c3ncccc3C#N)CC2)C1,3.1437800000000014
63889,Please optimize the molecule C#CCOc1c(C(F)(F)F)nn(-c2ccccc2)c1C to have a higher LogP value.,C#CCOc1c(C(F)(F)F)nn(-c2ccccc2)c1C,3.211520000000001
13362,Please optimize the molecule CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(F)cc1 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(F)cc1,4.798900000000004
127737,Optimize the molecule C[C@H]1CCc2ccccc2N1C(=O)COc1ccc(-c2nnco2)cc1 to have a lower LogP value.,C[C@H]1CCc2ccccc2N1C(=O)COc1ccc(-c2nnco2)cc1,3.4833000000000025
55211,Modify the molecule O=C(COC(=O)c1cccc2c1C(=O)c1ccccc1C2=O)N[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,O=C(COC(=O)c1cccc2c1C(=O)c1ccccc1C2=O)N[C@H]1CCS(=O)(=O)C1,0.9220999999999999
37333,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)N1CC[C@@H](C)[C@H](O)C1 to have a higher LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)N1CC[C@@H](C)[C@H](O)C1,1.24142
154215,Modify the molecule CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1 to increase its LogP value.,CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1,4.721220000000004
239981,Please optimize the molecule C[C@H](Sc1nncn1C)C(=O)Nc1ccccc1SC(F)F to have a higher LogP value.,C[C@H](Sc1nncn1C)C(=O)Nc1ccccc1SC(F)F,3.249100000000001
81758,Please modify the molecule C#Cc1cc(F)c(NC(=O)NC[C@H]2CC[NH+](CCC)C2)c(F)c1 to increase its LogP value.,C#Cc1cc(F)c(NC(=O)NC[C@H]2CC[NH+](CCC)C2)c(F)c1,1.3823999999999992
153813,Optimize the molecule CN(CCCC(=O)N1CCC[C@H]1c1ccc[nH]1)S(=O)(=O)c1ccc(F)cc1 to have a lower LogP value.,CN(CCCC(=O)N1CCC[C@H]1c1ccc[nH]1)S(=O)(=O)c1ccc(F)cc1,2.9182000000000006
207419,Optimize the molecule C[C@@H](NC(=O)c1cccs1)C(=O)NCCc1cc(F)cc(F)c1 to have a higher LogP value.,C[C@@H](NC(=O)c1cccs1)C(=O)NCCc1cc(F)cc(F)c1,2.5035000000000007
24189,Modify the molecule O=c1[nH]nc(CC2CC[NH+](CCC(F)(F)F)CC2)n1-c1ccccc1 to decrease its LogP value.,O=c1[nH]nc(CC2CC[NH+](CCC(F)(F)F)CC2)n1-c1ccccc1,1.3503999999999994
179527,Please optimize the molecule CCC[C@H]1CN(C(=O)[C@H](Cc2ccccc2)NC(=O)c2ccco2)CCO1 to have a lower LogP value.,CCC[C@H]1CN(C(=O)[C@H](Cc2ccccc2)NC(=O)c2ccco2)CCO1,2.648200000000001
50680,Modify the molecule Cc1cccc([C@@H](CNS(=O)(=O)c2ccc(C)cc2F)N2CCOCC2)c1 to have a higher LogP value.,Cc1cccc([C@@H](CNS(=O)(=O)c2ccc(C)cc2F)N2CCOCC2)c1,2.794340000000001
129694,Modify the molecule Cc1cc(NC(=O)[C@@H]2COCC(=O)N2Cc2ccccc2)no1 to decrease its LogP value.,Cc1cc(NC(=O)[C@@H]2COCC(=O)N2Cc2ccccc2)no1,1.3491199999999997
198704,Please optimize the molecule C[NH+](C)[C@H](CNC(=O)N[C@@H](c1nccs1)C1CC1)c1cccs1 to have a lower LogP value.,C[NH+](C)[C@H](CNC(=O)N[C@@H](c1nccs1)C1CC1)c1cccs1,1.8407
242439,Modify the molecule COC[C@@H](NC(=O)c1cc(C2CC2)nc2c1c(C)nn2C)C(N)=O to have a lower LogP value.,COC[C@@H](NC(=O)c1cc(C2CC2)nc2c1c(C)nn2C)C(N)=O,0.38422000000000034
186726,Please modify the molecule C[C@@H](CO)NC(=O)C(=O)Nc1ccccc1COc1ccccc1 to decrease its LogP value.,C[C@@H](CO)NC(=O)C(=O)Nc1ccccc1COc1ccccc1,1.7010999999999994
230191,Please optimize the molecule COc1ccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)cc1 to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)cc1,4.343100000000003
83079,Please optimize the molecule O=C(CCc1ccccc1)N(Cc1cccnc1)c1nc2ccc(Br)cc2s1 to have a lower LogP value.,O=C(CCc1ccccc1)N(Cc1cccnc1)c1nc2ccc(Br)cc2s1,5.619800000000004
44670,Modify the molecule COc1ccc(N2CCN(CC(=O)NC3CCCC3)C2=O)cc1OC to increase its LogP value.,COc1ccc(N2CCN(CC(=O)NC3CCCC3)C2=O)cc1OC,2.0046
132742,Please modify the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cccc(F)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cccc(F)c3)CC2)cc1,2.2808200000000003
7968,Modify the molecule C[C@@H]1CCC[C@@H](C)N1S(=O)(=O)c1ccc(Br)cc1 to have a lower LogP value.,C[C@@H]1CCC[C@@H](C)N1S(=O)(=O)c1ccc(Br)cc1,3.4007000000000023
161727,Please modify the molecule COc1ccc(NC(=O)[C@@H](C)S(=O)(=O)c2ccc(Br)cc2)cc1 to increase its LogP value.,COc1ccc(NC(=O)[C@@H](C)S(=O)(=O)c2ccc(Br)cc2)cc1,3.258600000000002
31324,Modify the molecule C[C@@H]([NH2+][C@H](C)c1c[nH]c2ccc([N+](=O)[O-])cc12)C(=O)N1CCOCC1 to increase its LogP value.,C[C@@H]([NH2+][C@H](C)c1c[nH]c2ccc([N+](=O)[O-])cc12)C(=O)N1CCOCC1,0.9477999999999993
123794,Modify the molecule O=C(NCC#CCOc1ccccc1F)c1ccccc1[N+](=O)[O-] to increase its LogP value.,O=C(NCC#CCOc1ccccc1F)c1ccccc1[N+](=O)[O-],2.546100000000001
201514,Modify the molecule CS(=O)(=O)CC[NH+](Cc1ccc(N2CCCCC2)cc1)C1CC1 to increase its LogP value.,CS(=O)(=O)CC[NH+](Cc1ccc(N2CCCCC2)cc1)C1CC1,1.2688000000000013
203178,Modify the molecule Cc1ccc(C2=CC(=O)N(CC(=O)Nc3ccccc3F)c3ccccc3N2)cc1 to decrease its LogP value.,Cc1ccc(C2=CC(=O)N(CC(=O)Nc3ccccc3F)c3ccccc3N2)cc1,4.572420000000003
43888,Please modify the molecule CN(C)c1cc(C(=O)N2CCC[C@H](n3cccn3)C2)ccn1 to increase its LogP value.,CN(C)c1cc(C(=O)N2CCC[C@H](n3cccn3)C2)ccn1,1.8214
155333,Please modify the molecule CN(CCN(C)c1ccccc1)C(=O)C(=O)Nc1ccc2c(c1)COC2 to increase its LogP value.,CN(CCN(C)c1ccccc1)C(=O)C(=O)Nc1ccc2c(c1)COC2,2.2500999999999998
221693,Modify the molecule COc1cccc([C@@H](CO)NC(=O)N[C@H](c2ccc(F)cc2)C2CC2)c1 to have a higher LogP value.,COc1cccc([C@@H](CO)NC(=O)N[C@H](c2ccc(F)cc2)C2CC2)c1,3.318200000000002
137239,Optimize the molecule O=C(C[C@@H]1CSc2nc3c(cnn3-c3ccc(Cl)cc3)c(=O)n21)NC[C@@H]1CCCO1 to have a lower LogP value.,O=C(C[C@@H]1CSc2nc3c(cnn3-c3ccc(Cl)cc3)c(=O)n21)NC[C@@H]1CCCO1,2.567700000000001
247232,Modify the molecule O=C(CN1C(=O)N[C@H](CCc2ccccc2)C1=O)Nc1cccc(Br)c1 to have a lower LogP value.,O=C(CN1C(=O)N[C@H](CCc2ccccc2)C1=O)Nc1cccc(Br)c1,2.940800000000001
125339,Modify the molecule Cc1ncccc1O[C@H]1C[C@@H]([NH3+])C12CCCC2 to decrease its LogP value.,Cc1ncccc1O[C@H]1C[C@@H]([NH3+])C12CCCC2,1.7120199999999997
101976,Modify the molecule Cc1nc(-c2cccc(NC(=O)C(=O)N[C@@H]3C[C@H]3C3CCCCC3)c2)n[nH]1 to have a lower LogP value.,Cc1nc(-c2cccc(NC(=O)C(=O)N[C@@H]3C[C@H]3C3CCCCC3)c2)n[nH]1,2.8036200000000004
62618,Modify the molecule Cc1cc(NC(=O)N(CC2CC2)C2CCCCC2)ccc1N(C)C to decrease its LogP value.,Cc1cc(NC(=O)N(CC2CC2)C2CCCCC2)ccc1N(C)C,4.6376200000000045
76568,Please modify the molecule Cc1ccc(CCC(=O)Nc2cc(S(C)(=O)=O)ccc2Cl)cc1 to increase its LogP value.,Cc1ccc(CCC(=O)Nc2cc(S(C)(=O)=O)ccc2Cl)cc1,3.6232200000000017
190222,Please modify the molecule Cc1nc(C[C@@H](O)c2cc(Cl)ccc2Br)sc1C to decrease its LogP value.,Cc1nc(C[C@@H](O)c2cc(Cl)ccc2Br)sc1C,4.451940000000001
124554,Optimize the molecule CCC[NH+]1CCC(O)(C[C@@H]2C[C@H]3CC[C@@H]2C3)CC1 to have a lower LogP value.,CCC[NH+]1CCC(O)(C[C@@H]2C[C@H]3CC[C@@H]2C3)CC1,1.6324999999999994
137420,Please modify the molecule Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1 to increase its LogP value.,Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1,1.2703199999999997
231478,Please optimize the molecule CC(C)(C)c1nnc(CNc2ccc(F)cc2OCC2CC2)o1 to have a higher LogP value.,CC(C)(C)c1nnc(CNc2ccc(F)cc2OCC2CC2)o1,3.9071000000000025
195464,Modify the molecule COc1ccc(OC)c(-c2cc(C(=O)N3CCC[C@@H](OC)C3)no2)c1 to increase its LogP value.,COc1ccc(OC)c(-c2cc(C(=O)N3CCC[C@@H](OC)C3)no2)c1,2.609800000000001
106854,Modify the molecule NC(=O)[C@@H]1CN(C(=O)NCc2[nH+]ccn2CCCc2ccccc2)CCO1 to have a higher LogP value.,NC(=O)[C@@H]1CN(C(=O)NCc2[nH+]ccn2CCCc2ccccc2)CCO1,0.33070000000000066
124705,Modify the molecule Cc1ccc(NC(=O)Cn2nc(-c3ccc(Br)cc3)ccc2=O)cc1F to decrease its LogP value.,Cc1ccc(NC(=O)Cn2nc(-c3ccc(Br)cc3)ccc2=O)cc1F,3.7590200000000014
178437,Modify the molecule Cc1ccc2cc([C@H](c3nnnn3C(C)(C)C)[NH+]3CCN(C(=O)c4ccco4)CC3)c(=O)[nH]c2c1 to have a lower LogP value.,Cc1ccc2cc([C@H](c3nnnn3C(C)(C)C)[NH+]3CCN(C(=O)c4ccco4)CC3)c(=O)[nH]c2c1,1.3013200000000005
103586,Modify the molecule COc1cc(CN2CCS(=O)(=O)[C@@H](C)[C@H]2C)ccc1OCC(F)(F)F to increase its LogP value.,COc1cc(CN2CCS(=O)(=O)[C@@H](C)[C@H]2C)ccc1OCC(F)(F)F,2.643700000000001
56892,Please modify the molecule CNC(=O)COc1ccccc1CN1CCO[C@@H](C#N)C1 to decrease its LogP value.,CNC(=O)COc1ccccc1CN1CCO[C@@H](C#N)C1,0.5357799999999995
125352,Please optimize the molecule Cc1cccc2sc(NC(=O)CCNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)nc12 to have a lower LogP value.,Cc1cccc2sc(NC(=O)CCNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)nc12,2.8200200000000004
242574,Please modify the molecule CC(C)[C@@H](C[NH3+])C(=O)N1[C@@H](C(=O)[O-])CC[C@H]2CCCC[C@H]21 to decrease its LogP value.,CC(C)[C@@H](C[NH3+])C(=O)N1[C@@H](C(=O)[O-])CC[C@H]2CCCC[C@H]21,-0.19979999999999865
74071,Modify the molecule Cc1cccc([C@H](C)[NH2+][C@@H](C)Cn2ncc3ccccc3c2=O)c1C to decrease its LogP value.,Cc1cccc([C@H](C)[NH2+][C@@H](C)Cn2ncc3ccccc3c2=O)c1C,2.726440000000001
103389,Modify the molecule CC(=O)c1ccc(NC(=O)[C@H]2CCCN(S(C)(=O)=O)C2)cc1C to increase its LogP value.,CC(=O)c1ccc(NC(=O)[C@H]2CCCN(S(C)(=O)=O)C2)cc1C,1.8077200000000002
66215,Modify the molecule Cc1nc(-c2nnc(NC(=O)c3ccc(S(=O)(=O)N4CCC[C@H](C)C4)cc3)o2)cs1 to decrease its LogP value.,Cc1nc(-c2nnc(NC(=O)c3ccc(S(=O)(=O)N4CCC[C@H](C)C4)cc3)o2)cs1,3.1744200000000022
154895,Optimize the molecule CCc1c(C)nc([C@H]2CN(CC)CCO2)nc1NC to have a higher LogP value.,CCc1c(C)nc([C@H]2CN(CC)CCO2)nc1NC,1.7823199999999997
100945,Modify the molecule CN1C(=O)/C(=C\c2cccc(OC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)c2)SC1=S to have a higher LogP value.,CN1C(=O)/C(=C\c2cccc(OC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)c2)SC1=S,3.553200000000002
191590,Modify the molecule CCc1ccc([C@@H](O)c2cc3[nH]c(=O)[nH]c3cc2Br)o1 to have a higher LogP value.,CCc1ccc([C@@H](O)c2cc3[nH]c(=O)[nH]c3cc2Br)o1,2.8558000000000003
233611,Please optimize the molecule [NH3+][C@H](c1cccc(F)c1)[C@@H]1CCc2cccnc21 to have a lower LogP value.,[NH3+][C@H](c1cccc(F)c1)[C@@H]1CCc2cccnc21,2.2337
160705,Modify the molecule CN(Cc1ccc(Cl)nc1)C(=O)c1cccn1Cc1ccccc1 to have a lower LogP value.,CN(Cc1ccc(Cl)nc1)C(=O)c1cccn1Cc1ccccc1,3.857000000000003
99189,Optimize the molecule CCCNC(=O)[C@@H](C)NC(=O)c1ccc(-c2ccc3c(c2)OCCO3)s1 to have a lower LogP value.,CCCNC(=O)[C@@H](C)NC(=O)c1ccc(-c2ccc3c(c2)OCCO3)s1,2.830800000000001
149202,Modify the molecule Cc1nnc(SCc2nc(-c3cccs3)n[nH]2)n1[C@@H]1CCC[C@H](C)C1 to decrease its LogP value.,Cc1nnc(SCc2nc(-c3cccs3)n[nH]2)n1[C@@H]1CCC[C@H](C)C1,4.476620000000003
127868,Please optimize the molecule O=C(Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1)c1cn2ccccc2n1 to have a lower LogP value.,O=C(Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1)c1cn2ccccc2n1,2.2609000000000004
209888,Optimize the molecule COc1ccc(CNC(=O)C2CCN(c3ncccc3-c3nc(-c4cccc(F)c4)no3)CC2)cc1 to have a lower LogP value.,COc1ccc(CNC(=O)C2CCN(c3ncccc3-c3nc(-c4cccc(F)c4)no3)CC2)cc1,4.479100000000003
135512,Please optimize the molecule Cn1cc(C(=O)NCc2cccnc2-n2cncn2)c(C(C)(C)C)n1 to have a lower LogP value.,Cn1cc(C(=O)NCc2cccnc2-n2cncn2)c(C(C)(C)C)n1,1.6233000000000002
29076,Optimize the molecule C[C@H]1CCC[C@H](NS(=O)(=O)Cc2cccc(N)c2)[C@@H]1C to have a lower LogP value.,C[C@H]1CCC[C@H](NS(=O)(=O)Cc2cccc(N)c2)[C@@H]1C,2.512900000000001
42561,Optimize the molecule CC(C)c1ccccc1NC(=O)CCc1ccc2c(c1)OCCO2 to have a higher LogP value.,CC(C)c1ccccc1NC(=O)CCc1ccc2c(c1)OCCO2,4.1525000000000025
150120,Please optimize the molecule CC(C)C(=O)N[C@H]1CCC[NH+](Cc2ccc(N3CCOCC3)cc2)C1 to have a higher LogP value.,CC(C)C(=O)N[C@H]1CCC[NH+](Cc2ccc(N3CCOCC3)cc2)C1,0.842700000000002
201799,Please modify the molecule Nc1ccccc1C(=O)N1CCC(c2nnc(-c3ccccc3)o2)CC1 to increase its LogP value.,Nc1ccccc1C(=O)N1CCC(c2nnc(-c3ccccc3)o2)CC1,3.3386000000000022
201510,Please modify the molecule O[C@H](c1ccc(Cl)s1)[C@H]1CCc2ccccc2C1 to increase its LogP value.,O[C@H](c1ccc(Cl)s1)[C@H]1CCc2ccccc2C1,4.240000000000003
220360,Modify the molecule O=C(NCC[NH+]1CCC(O)CC1)c1ccc([C@H]2CCC[NH2+]C2)cc1 to have a lower LogP value.,O=C(NCC[NH+]1CCC(O)CC1)c1ccc([C@H]2CCC[NH2+]C2)cc1,-1.1031999999999957
36964,Optimize the molecule COc1ccc(CN[C@H](C(N)=O)C(C)(C)C)c(Br)c1OC to have a lower LogP value.,COc1ccc(CN[C@H](C(N)=O)C(C)(C)C)c(Br)c1OC,2.4558999999999997
142875,Please optimize the molecule C[C@@H](NC(=O)N[C@H]1CCC[C@H](C2CC2)C1)c1ccc(-c2cncnc2)cc1 to have a higher LogP value.,C[C@@H](NC(=O)N[C@H]1CCC[C@H](C2CC2)C1)c1ccc(-c2cncnc2)cc1,4.472600000000004
118208,Optimize the molecule C[C@@H](NC(=O)CCn1ccc2c(Br)cccc21)c1ccccc1 to have a lower LogP value.,C[C@@H](NC(=O)CCn1ccc2c(Br)cccc21)c1ccccc1,4.671300000000003
72080,Modify the molecule [NH3+]C1CCN(c2nc3ccsc3c(=O)n2Cc2ccc(F)cc2)CC1 to have a lower LogP value.,[NH3+]C1CCN(c2nc3ccsc3c(=O)n2Cc2ccc(F)cc2)CC1,1.8561
117868,Modify the molecule C[NH2+]Cc1ccccc1OCc1cccc(C)c1 to decrease its LogP value.,C[NH2+]Cc1ccccc1OCc1cccc(C)c1,2.26722
34176,Please optimize the molecule O=C(Nc1ccc(F)cc1)C1CCN(C(=O)Nc2ccc(Cl)cc2)CC1 to have a lower LogP value.,O=C(Nc1ccc(F)cc1)C1CCN(C(=O)Nc2ccc(Cl)cc2)CC1,4.3617000000000035
246037,Please optimize the molecule CS(=O)(=O)c1ccc(-n2c(N)nc3cnccc32)cc1 to have a higher LogP value.,CS(=O)(=O)c1ccc(-n2c(N)nc3cnccc32)cc1,1.4062
46036,Modify the molecule CN1C(=O)c2sccc2N2[C@@H](CCCC(=O)NCCc3c[nH]c4ccccc34)NN[C@@H]12 to increase its LogP value.,CN1C(=O)c2sccc2N2[C@@H](CCCC(=O)NCCc3c[nH]c4ccccc34)NN[C@@H]12,2.3681
143505,Modify the molecule CC1(C)CN(C(=O)c2ccc(CSc3ncn[nH]3)cc2)CCS1 to have a lower LogP value.,CC1(C)CN(C(=O)c2ccc(CSc3ncn[nH]3)cc2)CCS1,3.0646000000000013
75333,Please modify the molecule CCN(C(=O)c1csc(-c2cccs2)n1)c1cccc(F)c1 to increase its LogP value.,CCN(C(=O)c1csc(-c2cccs2)n1)c1cccc(F)c1,4.677400000000003
141853,Modify the molecule O=C(CCS(=O)(=O)C1CCCC1)Nc1cccc(-n2cnnn2)c1 to decrease its LogP value.,O=C(CCS(=O)(=O)C1CCCC1)Nc1cccc(-n2cnnn2)c1,1.3482999999999998
54693,Modify the molecule CC[C@H](C(=O)NCCc1n[nH]c(=O)[nH]1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,CC[C@H](C(=O)NCCc1n[nH]c(=O)[nH]1)c1cccc(C(F)(F)F)c1,1.9692999999999998
229034,Modify the molecule Cc1nc2ncnn2c(NCC2CCN(C(=O)c3ccccc3)CC2)c1C to have a higher LogP value.,Cc1nc2ncnn2c(NCC2CCN(C(=O)c3ccccc3)CC2)c1C,2.705440000000001
123413,Modify the molecule C[C@@H]1C[C@H](Nc2cc(Cl)nc(N)n2)C(=O)N1c1ccccc1 to decrease its LogP value.,C[C@@H]1C[C@H](Nc2cc(Cl)nc(N)n2)C(=O)N1c1ccccc1,2.3181000000000003
85156,Optimize the molecule CC(C)Oc1ccc([C@H](C)Nc2c(C#N)c(=O)n(C)c(=O)n2C)cc1 to have a higher LogP value.,CC(C)Oc1ccc([C@H](C)Nc2c(C#N)c(=O)n(C)c(=O)n2C)cc1,1.9159799999999996
180873,Optimize the molecule Cc1cccc(C)c1NC(=O)CN1CC[NH+](Cc2cccc(Cl)c2)CC1 to have a higher LogP value.,Cc1cccc(C)c1NC(=O)CN1CC[NH+](Cc2cccc(Cl)c2)CC1,2.2960400000000005
76247,Please modify the molecule COc1ccc(CCN2C(=O)/C(=C/c3ccc(Br)cc3)SC2=S)cc1OC to increase its LogP value.,COc1ccc(CCN2C(=O)/C(=C/c3ccc(Br)cc3)SC2=S)cc1OC,4.910200000000004
190428,Please optimize the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)NC1CCC(O)CC1 to have a higher LogP value.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)NC1CCC(O)CC1,2.527
181699,Please optimize the molecule CC(C)[C@@H](O)CCNC(=O)c1ccc([S@@](=O)C(C)C)cc1 to have a lower LogP value.,CC(C)[C@@H](O)CCNC(=O)c1ccc([S@@](=O)C(C)C)cc1,2.3394000000000004
222880,Optimize the molecule CC/[NH+]=C(/NC[C@@H]1CC=CCC1)N1CCC(OCC)CC1 to have a higher LogP value.,CC/[NH+]=C(/NC[C@@H]1CC=CCC1)N1CCC(OCC)CC1,0.8897000000000004
70421,Modify the molecule COc1ccc(C)cc1S(=O)(=O)NCCc1c[nH]c2ccccc12 to have a higher LogP value.,COc1ccc(C)cc1S(=O)(=O)NCCc1c[nH]c2ccccc12,3.0059200000000006
233909,Optimize the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])N(Cc2cccc(Br)c2)C[C@H]2CCCO2)cc1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)/N=C(\[O-])N(Cc2cccc(Br)c2)C[C@H]2CCCO2)cc1,2.843720000000001
172835,Please optimize the molecule CSC1(C[NH2+][C@H](C)C(C)(C)C)CCOCC1 to have a higher LogP value.,CSC1(C[NH2+][C@H](C)C(C)(C)C)CCOCC1,1.8965999999999994
183395,Optimize the molecule CCC[C@H]1C[C@H]1NC(=O)c1ccc(-n2cncn2)c(C)c1 to have a lower LogP value.,CCC[C@H]1C[C@H]1NC(=O)c1ccc(-n2cncn2)c(C)c1,2.4941200000000006
56670,Modify the molecule C[C@@](O)(CNC(=O)c1ccccc1Nc1ccccc1)CN1CCOCC1 to have a lower LogP value.,C[C@@](O)(CNC(=O)c1ccccc1Nc1ccccc1)CN1CCOCC1,2.2432000000000007
184686,Modify the molecule CCn1/c(=N/C(=O)CC2(O)CCCC2)[nH]c2cc(Br)ccc21 to decrease its LogP value.,CCn1/c(=N/C(=O)CC2(O)CCCC2)[nH]c2cc(Br)ccc21,2.8743000000000007
194244,Modify the molecule C[C@@H]1CN(CC2CCCC2)C(C)(C)CO1 to have a higher LogP value.,C[C@@H]1CN(CC2CCCC2)C(C)(C)CO1,2.6759000000000013
81988,Modify the molecule Cc1ccc(C(=O)C2C(C)(C)C2(C)C)c(C)c1 to decrease its LogP value.,Cc1ccc(C(=O)C2C(C)(C)C2(C)C)c(C)c1,4.168340000000003
72638,Please modify the molecule c1ccc2c(c1)[nH]c1c(NC[C@@H]3CCCO3)ncnc12 to decrease its LogP value.,c1ccc2c(c1)[nH]c1c(NC[C@@H]3CCCO3)ncnc12,2.702
249137,Please modify the molecule COc1ccc(OC)c2[nH]c(=O)c(CCNC(=O)c3ccc(Br)cc3)cc12 to increase its LogP value.,COc1ccc(OC)c2[nH]c(=O)c(CCNC(=O)c3ccc(Br)cc3)cc12,3.2803000000000013
134472,Please optimize the molecule Cc1ccccc1CS[C@@H]1CC[C@@]([NH3+])(C(N)=O)C1 to have a lower LogP value.,Cc1ccccc1CS[C@@H]1CC[C@@]([NH3+])(C(N)=O)C1,1.2467199999999996
196868,Please optimize the molecule O=C(Cc1ccc[nH]1)NCc1[nH+]ccn1CCc1ccccc1 to have a lower LogP value.,O=C(Cc1ccc[nH]1)NCc1[nH+]ccn1CCc1ccccc1,1.731899999999999
109482,Please optimize the molecule Fc1cccc([C@@H]2CN(Cc3ccccc3N3CCOCC3)CCO2)c1 to have a lower LogP value.,Fc1cccc([C@@H]2CN(Cc3ccccc3N3CCOCC3)CCO2)c1,3.235800000000002
167676,Please modify the molecule CC(C)NC(=O)Nc1cccc(C(=O)N2CCCCC[C@H]2[C@H]2CCCCC2=O)c1 to decrease its LogP value.,CC(C)NC(=O)Nc1cccc(C(=O)N2CCCCC[C@H]2[C@H]2CCCCC2=O)c1,4.360600000000004
166583,Please optimize the molecule CC(C)(C)c1ccc([C@H](O)COc2ccc(N)cc2)cc1 to have a lower LogP value.,CC(C)(C)c1ccc([C@H](O)COc2ccc(N)cc2)cc1,3.678700000000002
125214,Optimize the molecule C[NH+]1CCC[C@@H](C(=O)NCC(C)(C)Cc2ccccc2)C1 to have a higher LogP value.,C[NH+]1CCC[C@@H](C(=O)NCC(C)(C)Cc2ccccc2)C1,1.2962000000000007
150533,Please optimize the molecule Cc1csc(/N=C2/S/C(=C3\C(=O)Nc4ccccc43)C(=O)N2C)n1 to have a higher LogP value.,Cc1csc(/N=C2/S/C(=C3\C(=O)Nc4ccccc43)C(=O)N2C)n1,3.007620000000002
17166,Modify the molecule Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1 to increase its LogP value.,Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1,4.625720000000003
207512,Optimize the molecule CC(C)CN(C(=O)CN1CCO[C@@H](c2ccc(F)cc2)C1)C1CC1 to have a lower LogP value.,CC(C)CN(C(=O)CN1CCO[C@@H](c2ccc(F)cc2)C1)C1CC1,2.846000000000001
163779,Optimize the molecule CC[C@H](NC(=O)N1CCCC1(C)C)c1cccc([N+](=O)[O-])c1 to have a lower LogP value.,CC[C@H](NC(=O)N1CCCC1(C)C)c1cccc([N+](=O)[O-])c1,3.629900000000003
55006,Please optimize the molecule C[S@](=O)c1cccc(NC(=O)NCCC[NH2+]C2CCCCC2)c1 to have a lower LogP value.,C[S@](=O)c1cccc(NC(=O)NCCC[NH2+]C2CCCCC2)c1,1.8316999999999997
139705,Please modify the molecule Cc1ccc(S(=O)(=O)O[C@@H]2[C@@H]([O-])[C@@H]([NH2+][C@@H](C)c3ccccc3)[C@H]3CO[C@@H]2O3)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)O[C@@H]2[C@@H]([O-])[C@@H]([NH2+][C@@H](C)c3ccccc3)[C@H]3CO[C@@H]2O3)cc1,0.24612000000000234
188050,Modify the molecule CCC[NH2+][C@@H](CC)c1cncc(Br)c1 to increase its LogP value.,CCC[NH2+][C@@H](CC)c1cncc(Br)c1,2.2686
79815,Please modify the molecule Cc1cc(/C=N/N=C2\C(=O)Nc3ccccc32)c(C)n1CC(C)C to decrease its LogP value.,Cc1cc(/C=N/N=C2\C(=O)Nc3ccccc32)c(C)n1CC(C)C,3.536240000000002
36551,Please optimize the molecule CCCNC(=S)NNC(=O)c1cc(C)oc1C to have a higher LogP value.,CCCNC(=S)NNC(=O)c1cc(C)oc1C,1.4153399999999998
210393,Please modify the molecule CC(C)(C)c1ccc(NC(=O)CN2C(=O)N[C@@](C)(c3ccccc3)C2=O)cc1 to decrease its LogP value.,CC(C)(C)c1ccc(NC(=O)CN2C(=O)N[C@@](C)(c3ccccc3)C2=O)cc1,3.389800000000002
205794,Modify the molecule COc1ccc(N2C(=O)CCCC2=O)cc1S(=O)(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1 to increase its LogP value.,COc1ccc(N2C(=O)CCCC2=O)cc1S(=O)(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1,0.8742000000000019
208743,Please optimize the molecule CCCC[C@@H](C(=O)[O-])[C@](O)(CC)c1ccc(Cl)cc1 to have a higher LogP value.,CCCC[C@@H](C(=O)[O-])[C@](O)(CC)c1ccc(Cl)cc1,2.493900000000001
235629,Modify the molecule O=C(CC[C@H]1CCCO1)NCc1cccc(N2CCOC2=O)c1 to have a lower LogP value.,O=C(CC[C@H]1CCCO1)NCc1cccc(N2CCOC2=O)c1,2.2186000000000003
158925,Modify the molecule COc1coc(C(=O)Nc2ccc(NC(C)=O)cc2)cc1=O to decrease its LogP value.,COc1coc(C(=O)Nc2ccc(NC(C)=O)cc2)cc1=O,1.8590999999999998
53851,Modify the molecule CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21 to have a higher LogP value.,CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21,3.1949000000000014
169197,Please optimize the molecule C[C@H](N[C@H]1CCCC[C@@H]1[C@@H]1CCCC[NH2+]1)c1ccccc1 to have a higher LogP value.,C[C@H](N[C@H]1CCCC[C@@H]1[C@@H]1CCCC[NH2+]1)c1ccccc1,3.0119000000000007
88302,Modify the molecule CCC(=O)NC(=S)Nc1ccccc1I to decrease its LogP value.,CCC(=O)NC(=S)Nc1ccccc1I,2.5142000000000007
120878,Please modify the molecule CCN(CC)C(=O)[C@@H]1CCC[NH+]1Cc1n[nH]c(=O)[nH]1 to increase its LogP value.,CCN(CC)C(=O)[C@@H]1CCC[NH+]1Cc1n[nH]c(=O)[nH]1,-1.4862999999999966
59725,Please optimize the molecule COc1ccc(NC(=O)c2ccc(C)[nH]c2=O)cc1OCC(F)(F)F to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(C)[nH]c2=O)cc1OCC(F)(F)F,2.885320000000001
248456,Optimize the molecule CC(C)(C)[C@@H]([NH3+])CCc1cc(F)ccc1Br to have a lower LogP value.,CC(C)(C)[C@@H]([NH3+])CCc1cc(F)ccc1Br,3.1774000000000013
230526,Please modify the molecule CC(=O)c1ccc2ccccc2c1OCc1ccccc1C#N to decrease its LogP value.,CC(=O)c1ccc2ccccc2c1OCc1ccccc1C#N,4.4930800000000035
225324,Please modify the molecule Cc1cc2occ(CC(=O)O[C@H]3CCCCNC3=O)c2cc1C to increase its LogP value.,Cc1cc2occ(CC(=O)O[C@H]3CCCCNC3=O)c2cc1C,2.8040400000000005
139720,Please optimize the molecule Cc1cc(C(=O)N[C@H](C(=O)[O-])c2c(C)n[nH]c2C)c2ccc(C)c(C)c2n1 to have a lower LogP value.,Cc1cc(C(=O)N[C@H](C(=O)[O-])c2c(C)n[nH]c2C)c2ccc(C)c(C)c2n1,1.7209999999999999
135347,Modify the molecule Cc1ccccc1-n1nnnc1SCC(=O)c1c(N)n(C)c(=O)n(C)c1=O to increase its LogP value.,Cc1ccccc1-n1nnnc1SCC(=O)c1c(N)n(C)c(=O)n(C)c1=O,-0.07468000000000008
88876,Modify the molecule CCNc1ncc(CN2C(=O)CN(C)C2=O)s1 to decrease its LogP value.,CCNc1ncc(CN2C(=O)CN(C)C2=O)s1,0.9689000000000001
116281,Optimize the molecule CN(c1cccc(C#N)c1)[C@@H]1CCOC2(CCCCC2)C1 to have a higher LogP value.,CN(c1cccc(C#N)c1)[C@@H]1CCOC2(CCCCC2)C1,3.876380000000003
172898,Modify the molecule O=C1CN(CC(=O)Nc2nc3ccccc3s2)CCN1 to have a lower LogP value.,O=C1CN(CC(=O)Nc2nc3ccccc3s2)CCN1,0.6665999999999994
47145,Modify the molecule CC[C@@H]1CN(C(C)=O)CC[C@@H]1[NH2+]Cc1ccc(Cl)c(F)c1 to have a lower LogP value.,CC[C@@H]1CN(C(C)=O)CC[C@@H]1[NH2+]Cc1ccc(Cl)c(F)c1,2.1895000000000007
139342,Please optimize the molecule C[C@@H]1CC[C@H](C#N)[C@H](n2cnc3ccccc32)C1 to have a higher LogP value.,C[C@@H]1CC[C@H](C#N)[C@H](n2cnc3ccccc32)C1,3.537180000000002
37569,Modify the molecule CC[C@H](C)C(=O)NC(C)(C)c1ccc(F)cc1Cl to decrease its LogP value.,CC[C@H](C)C(=O)NC(C)(C)c1ccc(F)cc1Cl,3.8765000000000027
233286,Please modify the molecule Cn1ncnc1CCNC1=NS(=O)(=O)c2ccccc21 to increase its LogP value.,Cn1ncnc1CCNC1=NS(=O)(=O)c2ccccc21,0.09630000000000033
45251,Optimize the molecule CCC1([C@@H](O)c2cc(OC)c(OC)cc2Cl)CCCC1 to have a higher LogP value.,CCC1([C@@H](O)c2cc(OC)c(OC)cc2Cl)CCCC1,4.361000000000003
223942,Please optimize the molecule Cc1csc2c(NNc3c4ccccc4nc4ccccc34)ncnc12 to have a lower LogP value.,Cc1csc2c(NNc3c4ccccc4nc4ccccc34)ncnc12,5.140120000000003
37936,Please optimize the molecule COCCCNC(=O)[C@@H](C)S(=O)(=O)c1ccc2c(c1)OCCO2 to have a higher LogP value.,COCCCNC(=O)[C@@H](C)S(=O)(=O)c1ccc2c(c1)OCCO2,0.7726999999999999
90099,Please modify the molecule COc1cc(NCCC[C@H](C)[NH3+])c2ncccc2c1 to decrease its LogP value.,COc1cc(NCCC[C@H](C)[NH3+])c2ncccc2c1,2.065899999999999
178302,Modify the molecule CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C to have a lower LogP value.,CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C,2.3631
17076,Modify the molecule C[NH+]1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)nc3ccccc23)CC1 to have a higher LogP value.,C[NH+]1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)nc3ccccc23)CC1,1.6010000000000002
181219,Modify the molecule CC[C@]1(c2ccccc2)NC(=O)N(Cc2cc(=O)n(C)c(=O)n2C)C1=O to have a lower LogP value.,CC[C@]1(c2ccccc2)NC(=O)N(Cc2cc(=O)n(C)c(=O)n2C)C1=O,0.44130000000000025
51627,Modify the molecule COc1cc(C)sc1C(=O)NNC(=O)Cc1cccc2ccccc12 to have a higher LogP value.,COc1cc(C)sc1C(=O)NNC(=O)Cc1cccc2ccccc12,3.2220200000000014
77417,Please modify the molecule N#C[C@@H](C(=O)c1cscn1)c1nc(N)nc(Nc2ccccc2)n1 to decrease its LogP value.,N#C[C@@H](C(=O)c1cscn1)c1nc(N)nc(Nc2ccccc2)n1,2.14398
18890,Optimize the molecule CC(C)([C@@H](N)c1ccc(Cl)s1)[NH+]1CCCCC1 to have a higher LogP value.,CC(C)([C@@H](N)c1ccc(Cl)s1)[NH+]1CCCCC1,2.2487000000000004
42285,Please optimize the molecule Cc1nn(C)c(C)c1CC(=O)Nc1ccccc1N1CCc2sccc2C1 to have a higher LogP value.,Cc1nn(C)c(C)c1CC(=O)Nc1ccccc1N1CCc2sccc2C1,3.8423400000000028
41022,Modify the molecule CCOC(=O)C1(C)CCN(C(=O)c2oc(C)nc2C)CC1 to have a higher LogP value.,CCOC(=O)C1(C)CCN(C(=O)c2oc(C)nc2C)CC1,2.0968400000000003
102761,Optimize the molecule Cc1ccc(-c2nnc(C[NH2+]CCn3cc(C)cn3)o2)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(C[NH2+]CCn3cc(C)cn3)o2)cc1,1.3135399999999993
51754,Please modify the molecule O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1 to decrease its LogP value.,O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1,2.706800000000001
77364,Please modify the molecule Cc1noc(CCCNC(=O)N2C[C@@H](C)[C@H]2c2ccccc2)n1 to increase its LogP value.,Cc1noc(CCCNC(=O)N2C[C@@H](C)[C@H]2c2ccccc2)n1,2.7132200000000006
230722,Please modify the molecule N#Cc1ccc(Cl)cc1NC(=O)C(=O)NCCC(c1ccccc1)c1ccccc1 to decrease its LogP value.,N#Cc1ccc(Cl)cc1NC(=O)C(=O)NCCC(c1ccccc1)c1ccccc1,4.4885800000000025
149099,Optimize the molecule COC(=O)c1cc(S(=O)(=O)NCc2cc3ccccc3o2)cn1C to have a lower LogP value.,COC(=O)c1cc(S(=O)(=O)NCc2cc3ccccc3o2)cn1C,2.0364
67521,Please optimize the molecule COc1ccc(CC(=O)Nc2ccn(Cc3cccc4ccccc34)n2)cc1 to have a lower LogP value.,COc1ccc(CC(=O)Nc2ccn(Cc3cccc4ccccc34)n2)cc1,4.274400000000003
152409,Modify the molecule Cc1ccccc1[C@H]1CC(=O)c2c(C)nc(NCCCN3CCOCC3)nc2C1 to increase its LogP value.,Cc1ccccc1[C@H]1CC(=O)c2c(C)nc(NCCCN3CCOCC3)nc2C1,3.140340000000002
6719,Please optimize the molecule COc1ncccc1Cn1cc(CCO)nn1 to have a lower LogP value.,COc1ncccc1Cn1cc(CCO)nn1,0.26479999999999976
238828,Please modify the molecule C/C(=N\NC(=O)CNc1ccc(C)cc1)c1ccc(N)cc1 to decrease its LogP value.,C/C(=N\NC(=O)CNc1ccc(C)cc1)c1ccc(N)cc1,2.5295199999999998
24122,Please modify the molecule CC[NH+](Cc1nc2cc(N)ccc2o1)C1CCCCC1 to increase its LogP value.,CC[NH+](Cc1nc2cc(N)ccc2o1)C1CCCCC1,2.1475
47427,Please optimize the molecule CCOc1cc(SC(=S)N2CCCC2)ccc1[N+](=O)[O-] to have a higher LogP value.,CCOc1cc(SC(=S)N2CCCC2)ccc1[N+](=O)[O-],3.466300000000002
249108,Please optimize the molecule NC(=O)N1CCC[C@@H](C(=O)Oc2ccc(Br)cc2)C1 to have a lower LogP value.,NC(=O)N1CCC[C@@H](C(=O)Oc2ccc(Br)cc2)C1,2.1452
177687,Please optimize the molecule CS(=O)(=O)NC[C@H]1CCCN(C(=O)Cn2nnc3ccccc32)C1 to have a higher LogP value.,CS(=O)(=O)NC[C@H]1CCCN(C(=O)Cn2nnc3ccccc32)C1,0.21910000000000074
221043,Please optimize the molecule CC[C@@H](Nc1ccn(C)n1)C(=O)[O-] to have a lower LogP value.,CC[C@@H](Nc1ccn(C)n1)C(=O)[O-],-0.6395000000000004
69977,Modify the molecule CCS[C@H]1CCCC[C@H]1NC(=O)NCc1[nH+]ccn1CC(C)C to increase its LogP value.,CCS[C@H]1CCCC[C@H]1NC(=O)NCc1[nH+]ccn1CC(C)C,2.8217000000000008
144097,Modify the molecule C=CCN1C(=O)C(C#N)=C(C)/C(=C\c2cn(-c3ccccc3)nc2-c2ccc(SCC)cc2)C1=O to have a lower LogP value.,C=CCN1C(=O)C(C#N)=C(C)/C(=C\c2cn(-c3ccccc3)nc2-c2ccc(SCC)cc2)C1=O,5.429580000000004
158111,Modify the molecule COc1ccccc1NC(=O)N1CCC(CNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)N1CCC(CNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1,3.2062000000000017
99132,Please modify the molecule Cc1ccc(N2CCCN(Cc3cnc(-c4cccnc4)s3)CC2)nn1 to decrease its LogP value.,Cc1ccc(N2CCCN(Cc3cnc(-c4cccnc4)s3)CC2)nn1,3.0158200000000015
127764,Please modify the molecule Fc1ccc(-c2noc(CC3C[NH2+]C3)n2)nc1 to increase its LogP value.,Fc1ccc(-c2noc(CC3C[NH2+]C3)n2)nc1,0.006399999999999351
187259,Please modify the molecule COc1ccc(Cl)c(NNC(=O)NCC[NH+]2CCC[C@@H](C)C2)c1 to decrease its LogP value.,COc1ccc(Cl)c(NNC(=O)NCC[NH+]2CCC[C@@H](C)C2)c1,1.2895000000000003
83707,Modify the molecule CCN(CC)c1ccc(C(=O)N/N=C(/C)c2cccnc2)cc1 to increase its LogP value.,CCN(CC)c1ccc(C(=O)N/N=C(/C)c2cccnc2)cc1,3.081800000000001
77596,Optimize the molecule O=C(NC[C@@H](O)c1ccc(C(F)(F)F)cc1)c1cnccn1 to have a higher LogP value.,O=C(NC[C@@H](O)c1ccc(C(F)(F)F)cc1)c1cnccn1,1.9588
34200,Please optimize the molecule C[C@H]1C(=O)N(CC(=O)NC(=O)NC(C)(C)C)C(=O)N1c1ccc(F)cc1 to have a lower LogP value.,C[C@H]1C(=O)N(CC(=O)NC(=O)NC(C)(C)C)C(=O)N1c1ccc(F)cc1,1.6070999999999995
203043,Optimize the molecule O=[N+]([O-])c1ccc(C[NH+]2CCC[C@@H]2C[C@H](O)c2ccco2)o1 to have a lower LogP value.,O=[N+]([O-])c1ccc(C[NH+]2CCC[C@@H]2C[C@H](O)c2ccco2)o1,1.4517999999999998
45803,Modify the molecule COc1ccc2nc(-c3cccc(NC(=O)C(c4ccccc4)c4ccccc4)c3)cn2n1 to have a lower LogP value.,COc1ccc2nc(-c3cccc(NC(=O)C(c4ccccc4)c4ccccc4)c3)cn2n1,5.175500000000005
15751,Modify the molecule Cc1ccc(S(=O)(=O)NCc2cnn(C)c2N)c(Br)c1 to decrease its LogP value.,Cc1ccc(S(=O)(=O)NCc2cnn(C)c2N)c(Br)c1,1.5517199999999998
171058,Please optimize the molecule Cc1ccc(/C=N/N2C(=S)[NH+]=N[C@H]2c2ccc(C(C)(C)C)cc2)o1 to have a lower LogP value.,Cc1ccc(/C=N/N2C(=S)[NH+]=N[C@H]2c2ccc(C(C)(C)C)cc2)o1,3.051520000000002
85827,Please modify the molecule CCc1nn(C)cc1C(=O)Oc1cccc(I)c1 to decrease its LogP value.,CCc1nn(C)cc1C(=O)Oc1cccc(I)c1,2.806300000000001
1012,Please modify the molecule COc1ccc(S(=O)(=O)N(CC(=O)N2CC[NH2+]CC2)C(C)C)cc1 to increase its LogP value.,COc1ccc(S(=O)(=O)N(CC(=O)N2CC[NH2+]CC2)C(C)C)cc1,-0.5000999999999973
215303,Modify the molecule O=C(NC[C@H]1CCCO1)[C@H](Cc1ccccc1)NC(=O)N1CCn2c1nc1ccccc12 to increase its LogP value.,O=C(NC[C@H]1CCCO1)[C@H](Cc1ccccc1)NC(=O)N1CCn2c1nc1ccccc12,2.4723999999999995
105991,Please optimize the molecule Nc1cc(C[NH+]2CCC[C@H]2CO)ccc1[N+](=O)[O-] to have a higher LogP value.,Nc1cc(C[NH+]2CCC[C@H]2CO)ccc1[N+](=O)[O-],-0.28339999999999943
204757,Optimize the molecule CC(=O)c1ccccc1NC(=O)CSc1nncs1 to have a higher LogP value.,CC(=O)c1ccccc1NC(=O)CSc1nncs1,2.4715000000000007
81820,Modify the molecule O=C(COC(=O)c1ccccc1I)Nc1cccc(Cl)c1 to decrease its LogP value.,O=C(COC(=O)c1ccccc1I)Nc1cccc(Cl)c1,3.7401000000000026
15080,Modify the molecule CCOC(=O)c1[nH]c(C)c(CCC(=O)Nc2cccc(C)c2C)c1C to have a higher LogP value.,CCOC(=O)c1[nH]c(C)c(CCC(=O)Nc2cccc(C)c2C)c1C,3.996380000000003
4106,Modify the molecule O=C(N[C@H](c1ccccc1)C1CC1)N1CCC(OCc2ccc(F)cc2)CC1 to decrease its LogP value.,O=C(N[C@H](c1ccccc1)C1CC1)N1CCC(OCc2ccc(F)cc2)CC1,4.667600000000005
205897,Please modify the molecule O=C(Nc1cccnc1)c1ccc(-c2cscn2)cc1 to increase its LogP value.,O=C(Nc1cccnc1)c1ccc(-c2cscn2)cc1,3.4574000000000016
148380,Optimize the molecule COCCN1C(=O)C[C@](CC(=O)NC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)(c2ccccc2C)C1=O to have a lower LogP value.,COCCN1C(=O)C[C@](CC(=O)NC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)(c2ccccc2C)C1=O,2.2281199999999988
213216,Modify the molecule CC(C)Oc1ncc(C(=O)N2C[C@H](C(N)=O)CC[C@@H]2C)cc1Cl to increase its LogP value.,CC(C)Oc1ncc(C(=O)N2C[C@H](C(N)=O)CC[C@@H]2C)cc1Cl,2.2481999999999998
181540,Modify the molecule O=C(C[C@@H]1CCCC[C@H]1O)c1ccccc1 to decrease its LogP value.,O=C(C[C@@H]1CCCC[C@H]1O)c1ccccc1,2.810500000000001
79705,Modify the molecule CC[C@H]1CN(C(=O)CCCN2C(=O)CNC2=O)CC[C@@H]1c1ccccc1 to have a higher LogP value.,CC[C@H]1CN(C(=O)CCCN2C(=O)CNC2=O)CC[C@@H]1c1ccccc1,2.3606999999999996
94481,Modify the molecule COCCn1cc(NC(=O)N2CCC(Nc3cccc(OC)c3)CC2)cn1 to have a higher LogP value.,COCCn1cc(NC(=O)N2CCC(Nc3cccc(OC)c3)CC2)cn1,2.6465000000000005
183039,Please optimize the molecule CC[C@H](C)CS(=O)(=O)NCCc1nc2ccccc2s1 to have a lower LogP value.,CC[C@H](C)CS(=O)(=O)NCCc1nc2ccccc2s1,2.8043000000000013
84173,Modify the molecule C/C=C(\C)C[NH+]1C[C@@H]2C(C(=O)NCc3cn4cc(C)sc4n3)[C@@H]2C1 to increase its LogP value.,C/C=C(\C)C[NH+]1C[C@@H]2C(C(=O)NCc3cn4cc(C)sc4n3)[C@@H]2C1,1.0473199999999996
25568,Optimize the molecule C[NH+]1CCN([C@@H]2CCCCN(C(=O)NCc3ccccn3)C2)CC1 to have a lower LogP value.,C[NH+]1CCN([C@@H]2CCCCN(C(=O)NCc3ccccn3)C2)CC1,-0.023999999999997135
147384,Please modify the molecule Cc1cc(C(=O)N2CCC3=NN=C(c4ccc(F)c(F)c4)[C@@H]3C2)n(C)n1 to decrease its LogP value.,Cc1cc(C(=O)N2CCC3=NN=C(c4ccc(F)c(F)c4)[C@@H]3C2)n(C)n1,2.3277200000000002
46548,Modify the molecule O=C(CCN1C(=O)NC2(CCCC2)C1=O)NC[C@H]1COc2ccccc2O1 to have a lower LogP value.,O=C(CCN1C(=O)NC2(CCCC2)C1=O)NC[C@H]1COc2ccccc2O1,1.1973000000000003
95908,Modify the molecule NC(=O)c1cccnc1N1CCN(CN2CCCCC2=O)CC1 to have a lower LogP value.,NC(=O)c1cccnc1N1CCN(CN2CCCCC2=O)CC1,0.2724999999999993
244293,Please optimize the molecule COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21 to have a higher LogP value.,COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21,2.3757400000000004
157696,Modify the molecule COc1ccc(/C=C2/SC(=S)N(c3cccc(C(F)(F)F)c3)C2=O)cc1 to increase its LogP value.,COc1ccc(/C=C2/SC(=S)N(c3cccc(C(F)(F)F)c3)C2=O)cc1,5.119800000000002
46228,Please optimize the molecule Cc1cc(N(C)Cc2nccn2Cc2ccccc2)n2ncnc2n1 to have a higher LogP value.,Cc1cc(N(C)Cc2nccn2Cc2ccccc2)n2ncnc2n1,2.3139200000000004
13038,Please optimize the molecule CCc1ccc(CC)c(NC(=O)[C@H](C)OCC2CC2)c1 to have a higher LogP value.,CCc1ccc(CC)c(NC(=O)[C@H](C)OCC2CC2)c1,3.565000000000002
117223,Optimize the molecule CCc1nc(N(C)C)c2c3c(sc2n1)CCC3 to have a higher LogP value.,CCc1nc(N(C)C)c2c3c(sc2n1)CCC3,2.8084000000000007
244570,Modify the molecule COc1ccc(-c2c3sc(=O)[nH]c3nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC to have a lower LogP value.,COc1ccc(-c2c3sc(=O)[nH]c3nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC,2.9013000000000018
178035,Please modify the molecule CC[NH2+][C@@H](C=C(C)C)[C@@H]1CCOc2ccccc21 to decrease its LogP value.,CC[NH2+][C@@H](C=C(C)C)[C@@H]1CCOc2ccccc21,2.4708000000000006
57532,Modify the molecule CCCc1c(N)nnn1Cc1nc(C)c(C)s1 to decrease its LogP value.,CCCc1c(N)nnn1Cc1nc(C)c(C)s1,1.93444
125057,Please modify the molecule C[C@H]1C[C@H](NC(=O)Cc2csc(NC(=O)c3cccs3)n2)CC(C)(C)C1 to decrease its LogP value.,C[C@H]1C[C@H](NC(=O)Cc2csc(NC(=O)c3cccs3)n2)CC(C)(C)C1,4.330400000000004
171884,Optimize the molecule Cc1ccc(-c2nn3c(=O)cc(CNC(=O)Nc4cc(C)ccc4C)nc3s2)cc1 to have a lower LogP value.,Cc1ccc(-c2nn3c(=O)cc(CNC(=O)Nc4cc(C)ccc4C)nc3s2)cc1,4.064960000000002
146537,Modify the molecule O=C1N[C@]2(CCCc3ccccc32)C(=O)N1Cc1nnc(-c2ccc(Cl)cc2)o1 to have a higher LogP value.,O=C1N[C@]2(CCCc3ccccc32)C(=O)N1Cc1nnc(-c2ccc(Cl)cc2)o1,3.673600000000002
59196,Modify the molecule CC[C@H](C)[C@@](C)(O)C[NH2+][C@@H](C)c1cnc2cc(C)nn2c1C to decrease its LogP value.,CC[C@H](C)[C@@](C)(O)C[NH2+][C@@H](C)c1cnc2cc(C)nn2c1C,1.7676399999999994
139131,Optimize the molecule C#CCN1CCN(CC(=O)Nc2cc(OC)ccc2OC)CC1 to have a lower LogP value.,C#CCN1CCN(CC(=O)Nc2cc(OC)ccc2OC)CC1,0.8930999999999996
83736,Modify the molecule N/C(N[C@H]1CCOc2ccccc21)=[NH+]\Cc1ccc(Cn2cncn2)cc1 to decrease its LogP value.,N/C(N[C@H]1CCOc2ccccc21)=[NH+]\Cc1ccc(Cn2cncn2)cc1,0.3351000000000002
48363,Optimize the molecule COc1ccc([C@@](C)([NH3+])[C@H]2CCOC3(CCCC3)C2)cc1 to have a lower LogP value.,COc1ccc([C@@](C)([NH3+])[C@H]2CCOC3(CCCC3)C2)cc1,2.891700000000001
246518,Optimize the molecule Cc1c(C(=O)NCCc2ccccc2)cnn1-c1ccncc1 to have a higher LogP value.,Cc1c(C(=O)NCCc2ccccc2)cnn1-c1ccncc1,2.5482200000000006
186406,Optimize the molecule COc1ccccc1Oc1ncnc(NNC(=O)c2ccc(Br)cc2)c1N to have a higher LogP value.,COc1ccccc1Oc1ncnc(NNC(=O)c2ccc(Br)cc2)c1N,3.3791
229481,Please optimize the molecule Cc1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1S(C)(=O)=O to have a higher LogP value.,Cc1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1S(C)(=O)=O,1.28422
239123,Modify the molecule CCN(CC)C(=O)[C@H]1Sc2nnc(C)n2N[C@@H]1c1ccc(OC)c(Br)c1 to increase its LogP value.,CCN(CC)C(=O)[C@H]1Sc2nnc(C)n2N[C@@H]1c1ccc(OC)c(Br)c1,2.985120000000001
112397,Modify the molecule CC(=O)Nc1cc(C)nn1-c1ncnc2c1cnn2-c1ccc(C)cc1C to decrease its LogP value.,CC(=O)Nc1cc(C)nn1-c1ncnc2c1cnn2-c1ccc(C)cc1C,2.8848600000000015
233635,Please modify the molecule CCOC(=O)[C@@H]1CC(=O)N(c2ccc(Br)cc2C)C1 to increase its LogP value.,CCOC(=O)[C@@H]1CC(=O)N(c2ccc(Br)cc2C)C1,2.673520000000001
95711,Please optimize the molecule Cc1ccc(N2C[C@H](C(=O)Nc3nnc(CC(C)(C)C)s3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(N2C[C@H](C(=O)Nc3nnc(CC(C)(C)C)s3)CC2=O)cc1,3.426720000000002
164523,Please modify the molecule CCn1cc(C[NH+]2CCC[C@H]2C(=O)[O-])c(C)n1 to decrease its LogP value.,CCn1cc(C[NH+]2CCC[C@H]2C(=O)[O-])c(C)n1,-1.491379999999998
112959,Optimize the molecule Cc1nc(CC[NH+]2CCC(Oc3ccc(Cl)cc3)CC2)cs1 to have a higher LogP value.,Cc1nc(CC[NH+]2CCC(Oc3ccc(Cl)cc3)CC2)cs1,2.773720000000001
172778,Modify the molecule C[C@@H](C(=O)[O-])[C@H](C)[S@@](=O)c1ccc(F)c(F)c1 to have a lower LogP value.,C[C@@H](C(=O)[O-])[C@H](C)[S@@](=O)c1ccc(F)c(F)c1,0.8469
34908,Optimize the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1 to have a higher LogP value.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1,3.6021000000000027
144914,Modify the molecule COc1ccccc1CNC(=O)CN1C[C@@H](C)C[C@H]([NH3+])C1 to have a lower LogP value.,COc1ccccc1CNC(=O)CN1C[C@@H](C)C[C@H]([NH3+])C1,0.26370000000000177
195965,Modify the molecule Cc1ccc([C@](C)(O)CNC(=O)CN2CCCOC2=O)o1 to decrease its LogP value.,Cc1ccc([C@](C)(O)CNC(=O)CN2CCCOC2=O)o1,0.7540200000000001
9579,Modify the molecule OCc1nn2c(c1Br)N[C@@H](c1ccc(Br)o1)C[C@@H]2C(F)(F)F to decrease its LogP value.,OCc1nn2c(c1Br)N[C@@H](c1ccc(Br)o1)C[C@@H]2C(F)(F)F,4.1537000000000015
223988,Optimize the molecule Cc1ccc(CN(C)c2ccc([N+](=O)[O-])c3cnccc23)o1 to have a lower LogP value.,Cc1ccc(CN(C)c2ccc([N+](=O)[O-])c3cnccc23)o1,3.6808200000000024
98054,Modify the molecule Clc1ccc2ncnc(O/N=C/c3ccc4c(c3)OCO4)c2c1 to have a lower LogP value.,Clc1ccc2ncnc(O/N=C/c3ccc4c(c3)OCO4)c2c1,3.424800000000001
189624,Modify the molecule [S-]c1nnc(-c2cccnc2)n1/N=C/c1ccccc1Br to have a higher LogP value.,[S-]c1nnc(-c2cccnc2)n1/N=C/c1ccccc1Br,2.890600000000001
40073,Please optimize the molecule O=C(Nc1ccc(F)c(Cl)c1)[C@H]1CCCN1S(=O)(=O)c1ccccc1 to have a lower LogP value.,O=C(Nc1ccc(F)c(Cl)c1)[C@H]1CCCN1S(=O)(=O)c1ccccc1,3.270900000000002
189060,Please modify the molecule CN(C)S(=O)(=O)c1c[nH]c(C(=O)NCC(F)(F)F)c1 to decrease its LogP value.,CN(C)S(=O)(=O)c1c[nH]c(C(=O)NCC(F)(F)F)c1,0.5571
210649,Please optimize the molecule CCOC(=O)C[C@@H](C)NC(=O)Cc1ccc(C)c(O)c1 to have a higher LogP value.,CCOC(=O)C[C@@H](C)NC(=O)Cc1ccc(C)c(O)c1,1.7010199999999995
141028,Optimize the molecule COc1ccc(/C=N/NC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cc1OC to have a lower LogP value.,COc1ccc(/C=N/NC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cc1OC,3.620300000000001
72379,Modify the molecule C=CCOc1ccccc1C(=O)Nc1ccc2ccccc2n1 to decrease its LogP value.,C=CCOc1ccccc1C(=O)Nc1ccc2ccccc2n1,4.0519000000000025
8499,Please modify the molecule OCC#Cc1ccc(Br)cc1 to decrease its LogP value.,OCC#Cc1ccc(Br)cc1,1.7928999999999997
28399,Please optimize the molecule COc1ccc(C(=O)Nc2nc(-c3ccc4c(c3)N(C)C(=O)[C@H](C)O4)cs2)cc1OC to have a higher LogP value.,COc1ccc(C(=O)Nc2nc(-c3ccc4c(c3)N(C)C(=O)[C@H](C)O4)cs2)cc1OC,3.8233000000000024
249238,Modify the molecule CCc1ccccc1NC(=O)C(=O)NC[C@H](C)C[C@@H](C)O to increase its LogP value.,CCc1ccccc1NC(=O)C(=O)NC[C@H](C)C[C@@H](C)O,1.7106999999999999
212519,Please modify the molecule Cc1ccc(NCC(=O)NNC(=O)c2ccc3c(c2)[nH]c(=O)n3C)cc1 to increase its LogP value.,Cc1ccc(NCC(=O)NNC(=O)c2ccc3c(c2)[nH]c(=O)n3C)cc1,1.0481199999999995
174430,Please optimize the molecule Cc1ccccc1C(=O)NCCC(=O)OCc1scnc1C to have a lower LogP value.,Cc1ccccc1C(=O)NCCC(=O)OCc1scnc1C,2.623240000000001
100541,Modify the molecule CN(CCc1ccccc1)S(=O)(=O)c1ccc2c(c1)OCCO2 to have a lower LogP value.,CN(CCc1ccccc1)S(=O)(=O)c1ccc2c(c1)OCCO2,2.3209999999999997
59301,Modify the molecule CSc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N([C@H]2CCC[C@@H](C)[C@H]2C)C1 to have a lower LogP value.,CSc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N([C@H]2CCC[C@@H](C)[C@H]2C)C1,3.478600000000002
103253,Optimize the molecule COc1cc(/C=C(\C#N)C(=O)Nc2cccc(C)c2C)cc2c1OCCO2 to have a lower LogP value.,COc1cc(/C=C(\C#N)C(=O)Nc2cccc(C)c2C)cc2c1OCCO2,3.6289200000000026
158960,Please optimize the molecule C[C@@H]1C[C@H]1C(=O)N1CCN(Cc2ccc(F)c(F)c2)CC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCN(Cc2ccc(F)c(F)c2)CC1,2.2650000000000006
136931,Modify the molecule C[C@@H](C(=O)Nc1cccc(C2SCCS2)c1)n1cncn1 to increase its LogP value.,C[C@@H](C(=O)Nc1cccc(C2SCCS2)c1)n1cncn1,2.9564000000000012
18470,Optimize the molecule C[C@@H](CNc1ncc(C(N)=O)cc1Cl)Nc1ccccc1 to have a higher LogP value.,C[C@@H](CNc1ncc(C(N)=O)cc1Cl)Nc1ccccc1,2.7464000000000004
54669,Please modify the molecule C[NH+](C)[C@@H]1c2ccccc2C2(CCN(C(=O)CCc3cccnc3)CC2)[C@H]1O to increase its LogP value.,C[NH+](C)[C@@H]1c2ccccc2C2(CCN(C(=O)CCc3cccnc3)CC2)[C@H]1O,1.1346999999999996
4173,Please modify the molecule CC(C)[NH+](C[C@@H](C)O)C1C[C@H](C)O[C@@H](C)C1 to increase its LogP value.,CC(C)[NH+](C[C@@H](C)O)C1C[C@H](C)O[C@@H](C)C1,0.6165000000000012
222641,Please modify the molecule O=C(Cc1ccccc1)NCC(=O)N[C@@H]1CCN(c2cccc(Cl)c2)C1 to decrease its LogP value.,O=C(Cc1ccccc1)NCC(=O)N[C@@H]1CCN(c2cccc(Cl)c2)C1,2.3937999999999997
228369,Modify the molecule CC(C)(C)[C@@H](Cn1cccn1)NC(=O)NC1CCCCC1 to decrease its LogP value.,CC(C)(C)[C@@H](Cn1cccn1)NC(=O)NC1CCCCC1,2.9297000000000013
118576,Optimize the molecule CCOC(=O)C1=C(CN2CCc3c(F)ccc(F)c3C2)NC(=O)NC1 to have a higher LogP value.,CCOC(=O)C1=C(CN2CCc3c(F)ccc(F)c3C2)NC(=O)NC1,1.4528999999999999
47957,Modify the molecule CCn1c(SCC(=O)NC2CCCC2)nnc1[C@H]1CCCN1C(=O)c1cccc(C)c1 to decrease its LogP value.,CCn1c(SCC(=O)NC2CCCC2)nnc1[C@H]1CCCN1C(=O)c1cccc(C)c1,3.7346200000000023
230604,Optimize the molecule O=C(NOCC(=O)N1CCN(c2[nH+]cc(C(F)(F)F)cc2Cl)CC1)c1ccccc1 to have a lower LogP value.,O=C(NOCC(=O)N1CCN(c2[nH+]cc(C(F)(F)F)cc2Cl)CC1)c1ccccc1,2.1831000000000005
11332,Modify the molecule Cc1cc(C)cc(NC(=O)[C@H](c2ccccc2)N2CC[NH+](CC(=O)N3CCOCC3)CC2)c1 to decrease its LogP value.,Cc1cc(C)cc(NC(=O)[C@H](c2ccccc2)N2CC[NH+](CC(=O)N3CCOCC3)CC2)c1,1.0425400000000018
141697,Please optimize the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)C3CC3)cc2)c1 to have a lower LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)C3CC3)cc2)c1,3.296000000000001
128676,Please optimize the molecule C=CCN(C(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C)c1ccccc1 to have a lower LogP value.,C=CCN(C(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C)c1ccccc1,1.4330999999999994
59228,Please modify the molecule CC(C)(C)OC(=O)N1CCC[C@H](C[NH2+]C2CCC2)C1 to decrease its LogP value.,CC(C)(C)OC(=O)N1CCC[C@H](C[NH2+]C2CCC2)C1,1.7494
98969,Optimize the molecule Fc1ccc(C[NH+]2CCC(NC3CCSCC3)CC2)cc1 to have a lower LogP value.,Fc1ccc(C[NH+]2CCC(NC3CCSCC3)CC2)cc1,1.8581999999999996
2083,Please modify the molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 to decrease its LogP value.,O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1,3.112300000000001
67655,Modify the molecule COC(=O)c1cccc(OC(=O)/C=C/c2ccccc2)c1 to increase its LogP value.,COC(=O)c1cccc(OC(=O)/C=C/c2ccccc2)c1,3.0920000000000014
126012,Please optimize the molecule OC1(CNc2nc3ccc(F)cn3n2)CCCCCC1 to have a higher LogP value.,OC1(CNc2nc3ccc(F)cn3n2)CCCCCC1,2.3656000000000006
73188,Modify the molecule C/C(=C/C[N+](C)(C)C)C[N+](C)(C)C to decrease its LogP value.,C/C(=C/C[N+](C)(C)C)C[N+](C)(C)C,1.3451
223245,Modify the molecule Cc1cccc(C)c1NC(=O)CNC(=O)NCc1cc(C#N)ccc1F to have a higher LogP value.,Cc1cccc(C)c1NC(=O)CNC(=O)NCc1cc(C#N)ccc1F,2.7521200000000006
115128,Modify the molecule CCc1cc(N(C)CC[C@H](C)O)nc(-c2ccccn2)n1 to have a higher LogP value.,CCc1cc(N(C)CC[C@H](C)O)nc(-c2ccccn2)n1,2.3081000000000005
22505,Modify the molecule Cc1ccc(CCN(Cc2ccco2)C(=O)CC2(O)CCCC2)cc1 to have a lower LogP value.,Cc1ccc(CCN(Cc2ccco2)C(=O)CC2(O)CCCC2)cc1,3.8545200000000035
16367,Modify the molecule CCc1nn(C)cc1NC(=O)N(CC)[C@@H](C)c1cc2ccccc2o1 to decrease its LogP value.,CCc1nn(C)cc1NC(=O)N(CC)[C@@H](C)c1cc2ccccc2o1,4.343700000000004
194,Please optimize the molecule O=C(NCCS(=O)(=O)c1ccccc1)N1CCC[C@@H]2CCC[C@@H]21 to have a lower LogP value.,O=C(NCCS(=O)(=O)c1ccccc1)N1CCC[C@@H]2CCC[C@@H]21,2.434400000000001
160720,Modify the molecule CC[C@@H](Oc1ccccc1F)C(=O)Nc1cc(OC)c(Cl)cc1OC to decrease its LogP value.,CC[C@@H](Oc1ccccc1F)C(=O)Nc1cc(OC)c(Cl)cc1OC,4.292400000000002
54326,Please modify the molecule Cc1cc(C)n(C[C@@H](C)CNC(=O)NC23CC4CC(CC(C4)C2)C3)n1 to decrease its LogP value.,Cc1cc(C)n(C[C@@H](C)CNC(=O)NC23CC4CC(CC(C4)C2)C3)n1,3.404040000000002
206696,Optimize the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NNC(=O)c1cccs1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NNC(=O)c1cccs1,1.9809999999999999
232878,Optimize the molecule CC1CCC(C(=O)c2ccccc2F)([NH+](C)C)CC1 to have a lower LogP value.,CC1CCC(C(=O)c2ccccc2F)([NH+](C)C)CC1,2.1018
61419,Modify the molecule CCc1ccc(S(=O)(=O)N(CC)CC2CC[NH2+]CC2)s1 to decrease its LogP value.,CCc1ccc(S(=O)(=O)N(CC)CC2CC[NH2+]CC2)s1,1.2945
112365,Please optimize the molecule CCCNC(=O)CNS(=O)(=O)c1ccc2c(c1)CCO2 to have a higher LogP value.,CCCNC(=O)CNS(=O)(=O)c1ccc2c(c1)CCO2,0.42599999999999977
98035,Modify the molecule CCNC(=O)NC(C)(C)c1ncc(C)s1 to decrease its LogP value.,CCNC(=O)NC(C)(C)c1ncc(C)s1,2.00572
15908,Please optimize the molecule CCc1nc(CN2CCC[C@H]([NH+](C)Cc3nc(C)c(C)o3)C2)no1 to have a lower LogP value.,CCc1nc(CN2CCC[C@H]([NH+](C)Cc3nc(C)c(C)o3)C2)no1,0.9161400000000008
236079,Optimize the molecule C/C=C/C(=O)Nc1cccc(C)c1C to have a higher LogP value.,C/C=C/C(=O)Nc1cccc(C)c1C,2.8180400000000017
170957,Please optimize the molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[C@@H](C)C2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[C@@H](C)C2,3.6441000000000026
241546,Optimize the molecule Cc1ccc(O)c(CN(C)C[C@@H]2CC[NH+](Cc3ccccc3)C2)c1 to have a lower LogP value.,Cc1ccc(O)c(CN(C)C[C@@H]2CC[NH+](Cc3ccccc3)C2)c1,2.2374199999999993
241063,Modify the molecule Cc1cccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)C(=O)N(C)C3=O)c1 to have a higher LogP value.,Cc1cccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)C(=O)N(C)C3=O)c1,2.5741200000000006
106159,Modify the molecule CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](C)c1ccc(C)o1 to increase its LogP value.,CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](C)c1ccc(C)o1,3.6099200000000025
200502,Modify the molecule O=C1C[C@H](Nc2cccc(F)c2)C(=O)N1c1cccc(Cl)c1 to increase its LogP value.,O=C1C[C@H](Nc2cccc(F)c2)C(=O)N1c1cccc(Cl)c1,3.2231000000000014
56787,Optimize the molecule CCN(C(=O)[C@H](C)Sc1nc2sc(C)c(C)c2c(=O)n1CC)[C@H]1CCS(=O)(=O)C1 to have a higher LogP value.,CCN(C(=O)[C@H](C)Sc1nc2sc(C)c(C)c2c(=O)n1CC)[C@H]1CCS(=O)(=O)C1,2.610940000000001
194692,Please optimize the molecule Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1 to have a lower LogP value.,Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1,2.1211199999999995
197741,Modify the molecule COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1 to increase its LogP value.,COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1,2.2047
145807,Modify the molecule O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1 to increase its LogP value.,O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1,3.5862000000000016
109290,Optimize the molecule O=C([O-])c1cn2ccccc2n1 to have a lower LogP value.,O=C([O-])c1cn2ccccc2n1,-0.30220000000000047
142399,Please optimize the molecule COc1ccc(F)cc1NC(=O)Cc1coc(-c2ccccc2)n1 to have a higher LogP value.,COc1ccc(F)cc1NC(=O)Cc1coc(-c2ccccc2)n1,3.6705000000000014
149159,Please modify the molecule CC[C@@H]1Oc2ccc(S(=O)(=O)N3CCC(C(=O)N(C)C4CCCCC4)CC3)cc2NC1=O to decrease its LogP value.,CC[C@@H]1Oc2ccc(S(=O)(=O)N3CCC(C(=O)N(C)C4CCCCC4)CC3)cc2NC1=O,2.9879000000000007
142849,Optimize the molecule COc1ccc(N2C(=O)CS[C@@]23C(=O)N(Cc2c(F)cccc2Cl)c2ccccc23)cc1 to have a lower LogP value.,COc1ccc(N2C(=O)CS[C@@]23C(=O)N(Cc2c(F)cccc2Cl)c2ccccc23)cc1,4.967300000000004
169107,Modify the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2cccc(-n3nnnc3C)c2)C1 to have a lower LogP value.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2cccc(-n3nnnc3C)c2)C1,2.51942
28236,Modify the molecule O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C/c1ccc(F)cc1 to have a lower LogP value.,O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C/c1ccc(F)cc1,2.3592000000000004
39743,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccc(Oc3cccnc3)nc2)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccc(Oc3cccnc3)nc2)C1,2.711900000000001
144959,Optimize the molecule O=[N+]([O-])c1cccc(OCc2nc(-c3ccncc3)no2)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(OCc2nc(-c3ccncc3)no2)c1,2.6188000000000002
236919,Please optimize the molecule O=S(=O)(Nc1ccc2c(c1)CCCN2S(=O)(=O)c1cccs1)c1cccc(Cl)c1 to have a lower LogP value.,O=S(=O)(Nc1ccc2c(c1)CCCN2S(=O)(=O)c1cccs1)c1cccc(Cl)c1,4.343800000000003
248624,Modify the molecule CCOC(=O)C[C@@H](C)CNC(=O)N[C@H]1c2ccccc2C[C@@H]1O to have a higher LogP value.,CCOC(=O)C[C@@H](C)CNC(=O)N[C@H]1c2ccccc2C[C@@H]1O,1.5331999999999997
152073,Modify the molecule O=C1NC(=O)[C@](c2cccnc2)(C2CCN(C(=O)c3ccc[nH]3)CC2)N1 to have a higher LogP value.,O=C1NC(=O)[C@](c2cccnc2)(C2CCN(C(=O)c3ccc[nH]3)CC2)N1,0.9967999999999999
184859,Modify the molecule COc1cc(OC)cc([C@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1 to have a higher LogP value.,COc1cc(OC)cc([C@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1,2.830700000000001
123377,Please modify the molecule Cn1cc(C[NH+]2CCc3onc(-c4ccccc4F)c3C2)c(-c2ccccc2)n1 to decrease its LogP value.,Cn1cc(C[NH+]2CCc3onc(-c4ccccc4F)c3C2)c(-c2ccccc2)n1,3.022400000000001
219949,Modify the molecule COc1ccc(F)cc1NC(=O)c1ccnc(C2CCCC2)n1 to have a lower LogP value.,COc1ccc(F)cc1NC(=O)c1ccnc(C2CCCC2)n1,3.534200000000002
24351,Optimize the molecule CC(C)Cn1c(=O)c2ccc(C(=O)NC3CCCC3)cc2n2c(=O)n(Cc3ccc(Cl)cc3)nc12 to have a higher LogP value.,CC(C)Cn1c(=O)c2ccc(C(=O)NC3CCCC3)cc2n2c(=O)n(Cc3ccc(Cl)cc3)nc12,3.841000000000003
101403,Modify the molecule CN1/C(=C(/C#N)C(=O)c2cc[n+](CC(=O)c3ccccc3)cc2)Nc2ccccc21 to increase its LogP value.,CN1/C(=C(/C#N)C(=O)c2cc[n+](CC(=O)c3ccccc3)cc2)Nc2ccccc21,3.336780000000002
160524,Please modify the molecule Cc1ccccc1-c1noc(CCC(=O)NCc2ccc(F)cc2)n1 to increase its LogP value.,Cc1ccccc1-c1noc(CCC(=O)NCc2ccc(F)cc2)n1,3.4331200000000006
233503,Optimize the molecule Cc1ccc2[nH]cc(CCC(=O)NC[C@H]3Cc4ccccc4O3)c2c1 to have a higher LogP value.,Cc1ccc2[nH]cc(CCC(=O)NC[C@H]3Cc4ccccc4O3)c2c1,3.5288200000000023
88434,Please optimize the molecule O=C(NCC1(c2ccccc2)CCC1)c1ccc(Cn2cncn2)cc1 to have a lower LogP value.,O=C(NCC1(c2ccccc2)CCC1)c1ccc(Cn2cncn2)cc1,3.1781000000000015
119190,Modify the molecule CC[C@H](CSC)[NH+](C)Cc1ccn(C(C)C)n1 to decrease its LogP value.,CC[C@H](CSC)[NH+](C)Cc1ccn(C(C)C)n1,1.6202999999999992
171962,Modify the molecule CC[C@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1ccc(Cl)nc1 to have a lower LogP value.,CC[C@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1ccc(Cl)nc1,3.6731000000000025
189977,Modify the molecule C[NH+](C)[C@H]1CCCN(Cn2nc(Br)nc2Br)C1 to increase its LogP value.,C[NH+](C)[C@H]1CCCN(Cn2nc(Br)nc2Br)C1,0.3694999999999997
207145,Optimize the molecule C[C@H](Sc1nnc(-c2ccco2)n1C1CCCCC1)C(=O)N(C)Cc1ccccc1 to have a lower LogP value.,C[C@H](Sc1nnc(-c2ccco2)n1C1CCCCC1)C(=O)N(C)Cc1ccccc1,5.1825000000000045
213309,Modify the molecule COc1ccccc1Nc1ncnc(N2CCc3ccccc3C2)c1N to increase its LogP value.,COc1ccccc1Nc1ncnc(N2CCc3ccccc3C2)c1N,3.3737000000000013
221095,Please modify the molecule COc1ccc(CNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1O to decrease its LogP value.,COc1ccc(CNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1O,2.778700000000001
212144,Please modify the molecule N#CCN(Cc1cnc(C2CCC2)s1)C1CCCC1 to increase its LogP value.,N#CCN(Cc1cnc(C2CCC2)s1)C1CCCC1,3.6787800000000033
21436,Please modify the molecule C[NH+](C)[C@H](CNC(=O)N1CCC[C@H]1Cc1cccc(F)c1)c1ccco1 to decrease its LogP value.,C[NH+](C)[C@H](CNC(=O)N1CCC[C@H]1Cc1cccc(F)c1)c1ccco1,2.021
79104,Please modify the molecule CN(C)c1ccc(CN(Cc2ccco2)C(=O)Nc2ccc(Cl)cc2)cc1 to increase its LogP value.,CN(C)c1ccc(CN(Cc2ccco2)C(=O)Nc2ccc(Cl)cc2)cc1,5.233300000000004
165535,Please optimize the molecule C[C@H]1CCN(C(=O)Nc2cc(C(F)(F)F)c[nH]c2=O)[C@H](C)C1 to have a lower LogP value.,C[C@H]1CCN(C(=O)Nc2cc(C(F)(F)F)c[nH]c2=O)[C@H](C)C1,3.046000000000001
194048,Modify the molecule CCCC(=O)N1CCC[C@@H](c2nc3c(c(=O)[nH]2)C[NH+](C)CC3)C1 to increase its LogP value.,CCCC(=O)N1CCC[C@@H](c2nc3c(c(=O)[nH]2)C[NH+](C)CC3)C1,-0.15319999999999734
182116,Please optimize the molecule Cc1cc(C)c(N/C=C(\C#N)c2nc(-c3cccc([N+](=O)[O-])c3)cs2)c(C)c1 to have a higher LogP value.,Cc1cc(C)c(N/C=C(\C#N)c2nc(-c3cccc([N+](=O)[O-])c3)cs2)c(C)c1,5.620140000000004
233874,Optimize the molecule CN(C)S(=O)(=O)n1cnc2ccccc21 to have a higher LogP value.,CN(C)S(=O)(=O)n1cnc2ccccc21,0.6907999999999996
127049,Please modify the molecule Cc1cc(NC(=O)[C@H]2CCOc3ccccc32)n(-c2ccccc2F)n1 to increase its LogP value.,Cc1cc(NC(=O)[C@H]2CCOc3ccccc32)n(-c2ccccc2F)n1,3.824620000000002
59785,Optimize the molecule CN(CCOCC1CC1)C(=O)c1ccc([S@](C)=O)cc1 to have a higher LogP value.,CN(CCOCC1CC1)C(=O)c1ccc([S@](C)=O)cc1,1.9226000000000003
59662,Please optimize the molecule O=C(NCc1ccc2c(c1)OCO2)[C@@H]1COc2ccccc2C1 to have a higher LogP value.,O=C(NCc1ccc2c(c1)OCO2)[C@@H]1COc2ccccc2C1,2.2828
56516,Modify the molecule CC[C@H](C)c1ccc(OCC(=O)Nc2ccc(NC(C)=O)cc2)cc1 to have a higher LogP value.,CC[C@H](C)c1ccc(OCC(=O)Nc2ccc(NC(C)=O)cc2)cc1,4.176000000000003
144873,Please modify the molecule CCOC(=O)c1cnn2c(N)c(C(=O)Nc3ccccc3Cl)nnc12 to increase its LogP value.,CCOC(=O)c1cnn2c(N)c(C(=O)Nc3ccccc3Cl)nnc12,1.7888999999999995
133726,Please optimize the molecule C[C@H]1Cc2ccccc2N1C(=O)Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21 to have a higher LogP value.,C[C@H]1Cc2ccccc2N1C(=O)Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21,2.8253000000000013
154457,Modify the molecule Cn1nccc1CNC(=O)N1CCN(C(=O)c2cccs2)CC1 to increase its LogP value.,Cn1nccc1CNC(=O)N1CCN(C(=O)c2cccs2)CC1,1.1492
204732,Modify the molecule Cn1cccc(NC(=O)NCC[C@@H](O)c2ccccc2)c1=O to have a lower LogP value.,Cn1cccc(NC(=O)NCC[C@@H](O)c2ccccc2)c1=O,1.6304999999999998
13213,Optimize the molecule CC(C)(C)Cc1nnc(NC(=O)CS(=O)(=O)c2ccccc2)s1 to have a lower LogP value.,CC(C)(C)Cc1nnc(NC(=O)CS(=O)(=O)c2ccccc2)s1,2.5391000000000004
239825,Please optimize the molecule O=S1(=O)CC[C@@H]([NH2+]Cc2ccc3c(c2)OCO3)C1 to have a lower LogP value.,O=S1(=O)CC[C@@H]([NH2+]Cc2ccc3c(c2)OCO3)C1,-0.33419999999999894
208373,Please optimize the molecule CCN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)S(=O)(=O)c1cc(Cl)ccc1Cl to have a higher LogP value.,CCN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)S(=O)(=O)c1cc(Cl)ccc1Cl,1.3073000000000001
176827,Modify the molecule CCCNC(=O)c1ccc(NC(=O)C2CCCC2)cc1 to have a higher LogP value.,CCCNC(=O)c1ccc(NC(=O)C2CCCC2)cc1,2.9551000000000016
249377,Please modify the molecule CC(C)CO[C@@H]1CC[C@H](O)C1 to decrease its LogP value.,CC(C)CO[C@@H]1CC[C@H](O)C1,1.5724
146378,Please optimize the molecule CN(C)C(=O)CCCC(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1 to have a lower LogP value.,CN(C)C(=O)CCCC(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1,2.5461
123714,Modify the molecule COCCN(Cc1ccco1)C(=O)c1cc(C(C)C)n(C)n1 to have a lower LogP value.,COCCN(Cc1ccco1)C(=O)c1cc(C(C)C)n(C)n1,2.425300000000001
138549,Please optimize the molecule C=CCCC(=O)Nc1ncc(C(F)(F)F)cc1Cl to have a lower LogP value.,C=CCCC(=O)Nc1ncc(C(F)(F)F)cc1Cl,3.658500000000002
162908,Optimize the molecule O=C1N(CCc2ccccc2)C[C@H]2C[C@@H](c3cnc(-c4ccccc4)s3)[NH+]3CCC[C@]123 to have a higher LogP value.,O=C1N(CCc2ccccc2)C[C@H]2C[C@@H](c3cnc(-c4ccccc4)s3)[NH+]3CCC[C@]123,3.3735000000000017
22769,Please modify the molecule O=S(=O)(c1ccc(Br)cc1Cl)N1CCN(Cc2cc(-c3ccccc3)no2)CC1 to increase its LogP value.,O=S(=O)(c1ccc(Br)cc1Cl)N1CCN(Cc2cc(-c3ccccc3)no2)CC1,4.264000000000005
216501,Please optimize the molecule CS[C@H](C)C[NH2+][C@@H](C)c1nc2c(s1)CCCC2 to have a higher LogP value.,CS[C@H](C)C[NH2+][C@@H](C)c1nc2c(s1)CCCC2,2.397800000000001
236434,Modify the molecule CCOC(=O)c1c(NC(=O)c2cc(=O)c3cc(C)cc(C)c3o2)sc(C)c1C to have a higher LogP value.,CCOC(=O)c1c(NC(=O)c2cc(=O)c3cc(C)cc(C)c3o2)sc(C)c1C,4.517180000000003
229072,Please modify the molecule COC(=O)[C@H]1CN(c2cc3ccccc3c(=O)[nH]2)C[C@H]1C to decrease its LogP value.,COC(=O)[C@H]1CN(c2cc3ccccc3c(=O)[nH]2)C[C@H]1C,1.7733999999999999
93356,Optimize the molecule COC(=O)[C@H](C)[C@H](C)[NH2+][C@H](C)c1ccccc1 to have a lower LogP value.,COC(=O)[C@H](C)[C@H](C)[NH2+][C@H](C)c1ccccc1,1.5085999999999995
225299,Modify the molecule Cc1ccnn1CCC(=O)N1CCCC[C@@H]1c1ccnc2cc(C(C)(C)C)nn12 to decrease its LogP value.,Cc1ccnn1CCC(=O)N1CCCC[C@@H]1c1ccnc2cc(C(C)(C)C)nn12,3.675620000000002
62382,Please modify the molecule O=C(Nc1cccc(-c2cn3ccsc3n2)c1)[C@H]1COc2ccccc2O1 to decrease its LogP value.,O=C(Nc1cccc(-c2cn3ccsc3n2)c1)[C@H]1COc2ccccc2O1,3.841300000000002
51136,Please modify the molecule CC[C@H](C#N)OC(=O)c1cnn(Cc2ccccc2)c1 to decrease its LogP value.,CC[C@H](C#N)OC(=O)c1cnn(Cc2ccccc2)c1,2.3903800000000004
87488,Modify the molecule CC(C)CNC(=O)Cc1ccc(NC(=O)c2cnc3c(c2)NC(=O)CO3)cc1 to have a lower LogP value.,CC(C)CNC(=O)Cc1ccc(NC(=O)c2cnc3c(c2)NC(=O)CO3)cc1,1.9794999999999994
109860,Please modify the molecule O=C(C[NH+]1CCCCC1)N1CCC[C@@H]([NH+]2CCN(c3cccc(Cl)c3)CC2)C1 to increase its LogP value.,O=C(C[NH+]1CCCCC1)N1CCC[C@@H]([NH+]2CCN(c3cccc(Cl)c3)CC2)C1,0.1047000000000029
187237,Please optimize the molecule COc1cccc(-n2cc(CN3C[C@@]4(CCOC4)CCC3=O)cn2)c1 to have a lower LogP value.,COc1cccc(-n2cc(CN3C[C@@]4(CCOC4)CCC3=O)cn2)c1,2.41
151722,Please modify the molecule CCCN(Cc1csc(-c2ccc(C(F)(F)F)cc2)n1)[C@H]1CCS(=O)(=O)C1 to decrease its LogP value.,CCCN(Cc1csc(-c2ccc(C(F)(F)F)cc2)n1)[C@H]1CCS(=O)(=O)C1,4.228000000000004
230567,Modify the molecule O=C(CNc1ccc(Cl)cc1NC(=O)c1ccco1)Nc1ccccc1 to have a higher LogP value.,O=C(CNc1ccc(Cl)cc1NC(=O)c1ccco1)Nc1ccccc1,4.235900000000002
218138,Modify the molecule CCOc1ccc(-c2nc(NCc3cccc(OC)c3O)sc2C)cc1 to increase its LogP value.,CCOc1ccc(-c2nc(NCc3cccc(OC)c3O)sc2C)cc1,4.843520000000005
141334,Please optimize the molecule CC(C)n1cc([C@@H](C)[NH2+]CCCC(=O)N2CCc3ccccc3C2)cn1 to have a higher LogP value.,CC(C)n1cc([C@@H](C)[NH2+]CCCC(=O)N2CCc3ccccc3C2)cn1,2.4535
230546,Optimize the molecule O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12 to have a lower LogP value.,O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12,3.2603000000000018
25722,Optimize the molecule O=C(c1ccco1)N1CCN(C(=O)[C@@H]2CCCN(c3nnc(-n4cccc4)s3)C2)CC1 to have a lower LogP value.,O=C(c1ccco1)N1CCN(C(=O)[C@@H]2CCCN(c3nnc(-n4cccc4)s3)C2)CC1,2.1228
238875,Please modify the molecule CC[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1cnn(C(C)C)c1 to decrease its LogP value.,CC[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1cnn(C(C)C)c1,3.4021000000000017
218841,Modify the molecule Cc1csc([C@@H](C)NCc2cccc(OC3CCCC3)c2)n1 to have a higher LogP value.,Cc1csc([C@@H](C)NCc2cccc(OC3CCCC3)c2)n1,4.623720000000003
55216,Please optimize the molecule O=C1OCC(c2ccc(Br)s2)=C1c1ccc(F)cc1 to have a higher LogP value.,O=C1OCC(c2ccc(Br)s2)=C1c1ccc(F)cc1,4.117300000000002
9807,Please optimize the molecule COc1ccccc1NC(=O)CNc1cccc(Cl)c1Cl to have a higher LogP value.,COc1ccccc1NC(=O)CNc1cccc(Cl)c1Cl,4.052600000000003
38878,Modify the molecule Cc1ccc(C)c([C@H](C)NC(=O)c2ccc(CN3CCOCC3)cc2)c1 to have a higher LogP value.,Cc1ccc(C)c([C@H](C)NC(=O)c2ccc(CN3CCOCC3)cc2)c1,3.6266400000000028
225327,Please optimize the molecule CN(C)C(=O)C1CC[NH+](Cc2cccc(C(=O)Nc3ccccc3)c2)CC1 to have a lower LogP value.,CN(C)C(=O)C1CC[NH+](Cc2cccc(C(=O)Nc3ccccc3)c2)CC1,1.8219999999999996
163871,Please optimize the molecule O=C(Cc1cccs1)NCCCCN1C(=O)c2ccccc2C1=O to have a higher LogP value.,O=C(Cc1cccs1)NCCCCN1C(=O)c2ccccc2C1=O,2.483200000000001
151299,Modify the molecule CCCCOCC(=O)N1CCc2c([nH]c3ccccc23)C1 to have a higher LogP value.,CCCCOCC(=O)N1CCc2c([nH]c3ccccc23)C1,2.869300000000001
176804,Modify the molecule COc1cc(C[NH+]2C[C@H]3[C@@H](C2)OCCN3C)ccc1OCc1ccccc1 to have a higher LogP value.,COc1cc(C[NH+]2C[C@H]3[C@@H](C2)OCCN3C)ccc1OCc1ccccc1,1.3719000000000015
29424,Optimize the molecule Cc1cc(C)n(-c2cncc(NCC(=O)N(C)CC(F)(F)F)n2)n1 to have a lower LogP value.,Cc1cc(C)n(-c2cncc(NCC(=O)N(C)CC(F)(F)F)n2)n1,1.7117399999999998
218377,Modify the molecule CCN(Cc1cccc(F)c1)C(=O)/C=C/c1cc2c(cc1[N+](=O)[O-])OCO2 to have a higher LogP value.,CCN(Cc1cccc(F)c1)C(=O)/C=C/c1cc2c(cc1[N+](=O)[O-])OCO2,3.5245000000000024
4111,Please modify the molecule O[C@@]12CCCC[C@@H]1[C@H](c1ccc(Cl)cc1Cl)[NH2+]CC2 to decrease its LogP value.,O[C@@]12CCCC[C@@H]1[C@H](c1ccc(Cl)cc1Cl)[NH2+]CC2,2.922900000000001
73895,Optimize the molecule CCS(=O)(=O)CCC[C@@H](CBr)c1ccc(F)cc1 to have a higher LogP value.,CCS(=O)(=O)CCC[C@@H](CBr)c1ccc(F)cc1,3.5191000000000026
54995,Please modify the molecule Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C to increase its LogP value.,Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C,1.5040000000000002
16578,Modify the molecule N#Cc1nccnc1Sc1nnnn1C1CC1 to have a lower LogP value.,N#Cc1nccnc1Sc1nnnn1C1CC1,0.8208799999999998
143251,Optimize the molecule CCOc1ccccc1OC/C([O-])=N/c1nc(-c2ccc(C)cc2)n[nH]1 to have a lower LogP value.,CCOc1ccccc1OC/C([O-])=N/c1nc(-c2ccc(C)cc2)n[nH]1,2.6481200000000005
179448,Optimize the molecule CC(=O)Nc1cccc(NC(=O)COc2cccc3c2CCC[C@@H]3O)c1 to have a higher LogP value.,CC(=O)Nc1cccc(NC(=O)COc2cccc3c2CCC[C@@H]3O)c1,3.0322000000000013
21051,Please optimize the molecule CC(C)Sc1ccc(C(=O)N2CCC(OCCN3C[C@@H](C)O[C@H](C)C3)CC2)cc1 to have a lower LogP value.,CC(C)Sc1ccc(C(=O)N2CCC(OCCN3C[C@@H](C)O[C@H](C)C3)CC2)cc1,3.917500000000003
39093,Modify the molecule CC(C)c1nc(CC(=O)N(C2CCC(O)CC2)S(C)(=O)=O)cs1 to decrease its LogP value.,CC(C)c1nc(CC(=O)N(C2CCC(O)CC2)S(C)(=O)=O)cs1,1.9007000000000003
171274,Please optimize the molecule O=C(Nc1nccs1)c1ccc(Cl)c(S(=O)(=O)N2CCCCCC2)c1 to have a lower LogP value.,O=C(Nc1nccs1)c1ccc(Cl)c(S(=O)(=O)N2CCCCCC2)c1,3.613500000000003
147006,Please modify the molecule COc1ccccc1N(CCC[NH3+])C(=O)N1CCCCC1 to decrease its LogP value.,COc1ccccc1N(CCC[NH3+])C(=O)N1CCCCC1,1.7395
139830,Modify the molecule CC[NH+](C)CC(=O)NCc1ccccc1Cn1cccn1 to have a higher LogP value.,CC[NH+](C)CC(=O)NCc1ccccc1Cn1cccn1,0.08220000000000116
231701,Please modify the molecule Cc1ccc(C[C@@H](C)NC(=O)CSc2nc(C)n[nH]2)c(C)c1 to decrease its LogP value.,Cc1ccc(C[C@@H](C)NC(=O)CSc2nc(C)n[nH]2)c(C)c1,2.5694600000000003
240402,Please optimize the molecule C[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccccc1 to have a lower LogP value.,C[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccccc1,2.5454000000000008
213330,Please modify the molecule O=C(Nc1cc(Cl)ccc1-n1cncn1)c1ccc(OC(F)(F)F)cc1 to increase its LogP value.,O=C(Nc1cc(Cl)ccc1-n1cncn1)c1ccc(OC(F)(F)F)cc1,4.071600000000001
146726,Optimize the molecule O=C(NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccs1 to have a higher LogP value.,O=C(NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccs1,0.696200000000001
51270,Please optimize the molecule O=C(NC(c1cccs1)c1cccs1)c1cccc2cc[nH]c12 to have a lower LogP value.,O=C(NC(c1cccs1)c1cccs1)c1cccc2cc[nH]c12,4.810300000000003
740,Please optimize the molecule CCc1ccc(/C=C(\C#N)C(N)=O)s1 to have a higher LogP value.,CCc1ccc(/C=C(\C#N)C(N)=O)s1,1.70278
141518,Modify the molecule O=C(NC(=S)N1CCCC[C@H]1c1cccnc1)c1cccnc1 to have a higher LogP value.,O=C(NC(=S)N1CCCC[C@H]1c1cccnc1)c1cccnc1,2.7185000000000015
115415,Please modify the molecule CC(=O)N[C@@H](CC(=O)NC1CCC(O)CC1)c1ccc(C)cc1 to decrease its LogP value.,CC(=O)N[C@@H](CC(=O)NC1CCC(O)CC1)c1ccc(C)cc1,1.9820199999999994
185039,Optimize the molecule Cn1c(SCn2nnc3ccccc3c2=O)nnc1-c1ccncc1 to have a lower LogP value.,Cn1c(SCn2nnc3ccccc3c2=O)nnc1-c1ccncc1,1.7317999999999998
120621,Please optimize the molecule COc1ccc(-c2nc3c(s2)CN(S(=O)(=O)c2ccc(Br)cc2)CC3)cc1 to have a higher LogP value.,COc1ccc(-c2nc3c(s2)CN(S(=O)(=O)c2ccc(Br)cc2)CC3)cc1,4.328200000000004
25419,Optimize the molecule CCOc1ccccc1[C@@H](C)[NH2+]Cc1cc(F)cc(OC)c1 to have a lower LogP value.,CCOc1ccccc1[C@@H](C)[NH2+]Cc1cc(F)cc(OC)c1,3.0576000000000016
237988,Please optimize the molecule O=C([O-])[C@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H](c2ccccc2)N1 to have a higher LogP value.,O=C([O-])[C@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H](c2ccccc2)N1,-2.2271999999999963
173708,Please optimize the molecule COc1cc(C[NH2+]C2CC2)cc(Cl)c1OC[C@@H]1CCCO1 to have a lower LogP value.,COc1cc(C[NH2+]C2CC2)cc(Cl)c1OC[C@@H]1CCCO1,2.1322
81109,Please optimize the molecule Cc1ccc(NC(=S)Nc2cc(C(F)(F)F)ccc2C)cc1 to have a lower LogP value.,Cc1ccc(NC(=S)Nc2cc(C(F)(F)F)ccc2C)cc1,5.131140000000003
56929,Optimize the molecule N#CC1=C(N)Oc2cc(O)ccc2[C@H]1c1cc(C[NH+]2CCOCC2)cs1 to have a lower LogP value.,N#CC1=C(N)Oc2cc(O)ccc2[C@H]1c1cc(C[NH+]2CCOCC2)cs1,1.0869799999999996
88041,Modify the molecule C[C@H](NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1)c1cccc(Cl)c1 to have a higher LogP value.,C[C@H](NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1)c1cccc(Cl)c1,4.462700000000002
245417,Optimize the molecule Cc1ccc(C)n1CCN1CCN(S(=O)(=O)c2cnn(C)c2)CC1 to have a lower LogP value.,Cc1ccc(C)n1CCN1CCN(S(=O)(=O)c2cnn(C)c2)CC1,0.8449400000000002
127626,Modify the molecule Cc1cc(C)c2c(C)c(C(=O)Nc3ccc4c(c3)NC(=O)[C@@H](C)O4)oc2c1 to decrease its LogP value.,Cc1cc(C)c2c(C)c(C(=O)Nc3ccc4c(c3)NC(=O)[C@@H](C)O4)oc2c1,4.329760000000002
159341,Please modify the molecule C[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1F to increase its LogP value.,C[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1F,4.057700000000003
226068,Please optimize the molecule Cc1noc(C2CCN(C(=O)N[C@@H](C)COc3ccc(F)cc3)CC2)n1 to have a higher LogP value.,Cc1noc(C2CCN(C(=O)N[C@@H](C)COc3ccc(F)cc3)CC2)n1,2.8736200000000016
204191,Modify the molecule CCNC(=O)C[C@@H](C[NH3+])N1CCO[C@H]2CCCC[C@@H]21 to decrease its LogP value.,CCNC(=O)C[C@@H](C[NH3+])N1CCO[C@H]2CCCC[C@@H]21,-0.23349999999999804
153957,Please optimize the molecule C[C@H]1CCC[C@@H]([NH+](C)C[C@H](O)COCc2ccc3c(c2)OCO3)C1 to have a higher LogP value.,C[C@H]1CCC[C@@H]([NH+](C)C[C@H](O)COCc2ccc3c(c2)OCO3)C1,1.3862000000000003
246581,Modify the molecule Cc1cccc([N+](=O)[O-])c1NC(=O)COc1ccc(F)cc1Br to increase its LogP value.,Cc1cccc([N+](=O)[O-])c1NC(=O)COc1ccc(F)cc1Br,3.822320000000002
239005,Modify the molecule C[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)o1)c1cccc(C#N)c1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)o1)c1cccc(C#N)c1,3.6669800000000023
10002,Modify the molecule C[C@H]1CN(CCn2cc[nH+]c2)CC[C@@H]1[NH3+] to decrease its LogP value.,C[C@H]1CN(CCn2cc[nH+]c2)CC[C@@H]1[NH3+],-0.7454999999999974
114307,Please optimize the molecule COCCn1c(C)cc(/C=C(/C#N)C(=O)N2CCCC[C@@H]2C)c1C to have a higher LogP value.,COCCn1c(C)cc(/C=C(/C#N)C(=O)N2CCCC[C@@H]2C)c1C,3.0593200000000014
202409,Modify the molecule Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1 to have a lower LogP value.,Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1,2.7259400000000005
187002,Please optimize the molecule CCN1/C(=N/C(=O)CCCC(=O)[O-])S[C@H]2CS(=O)(=O)C[C@@H]21 to have a higher LogP value.,CCN1/C(=N/C(=O)CCCC(=O)[O-])S[C@H]2CS(=O)(=O)C[C@@H]21,-0.9764999999999981
246105,Optimize the molecule CC[C@H]1COCCN1Cc1cc(F)cc(Br)c1 to have a lower LogP value.,CC[C@H]1COCCN1Cc1cc(F)cc(Br)c1,3.1990000000000016
30292,Optimize the molecule Cc1ccc(N2C(=O)C[C@H](Sc3ccccc3C(=O)[O-])C2=O)cc1 to have a lower LogP value.,Cc1ccc(N2C(=O)C[C@H](Sc3ccccc3C(=O)[O-])C2=O)cc1,1.7827199999999994
168749,Modify the molecule CC[C@H](C)CS(=O)(=O)Cc1nc(-c2ccco2)no1 to increase its LogP value.,CC[C@H](C)CS(=O)(=O)Cc1nc(-c2ccco2)no1,2.2905000000000006
18980,Optimize the molecule CC1(C)C[C@@H]2C[C@@](C)(CN2c2ncnc(NNC(=O)c3ccccc3F)c2N)C1 to have a higher LogP value.,CC1(C)C[C@@H]2C[C@@](C)(CN2c2ncnc(NNC(=O)c3ccccc3F)c2N)C1,3.359800000000001
192095,Please optimize the molecule CCC[C@@H](C)N1C[C@@H](C(=O)NC2(C(N)=O)CCCC2)CC1=O to have a higher LogP value.,CCC[C@@H](C)N1C[C@@H](C(=O)NC2(C(N)=O)CCCC2)CC1=O,0.9377999999999995
181946,Optimize the molecule COc1ccc(C(=O)Nc2c(O)cccc2F)cc1OC(F)F to have a lower LogP value.,COc1ccc(C(=O)Nc2c(O)cccc2F)cc1OC(F)F,3.393600000000001
30452,Please modify the molecule Cc1cc(NC(=O)[C@H](C[NH3+])CC(C)C)ccc1Br to increase its LogP value.,Cc1cc(NC(=O)[C@H](C[NH3+])CC(C)C)ccc1Br,2.60022
233685,Modify the molecule CN(C)c1ncccc1NC(=O)c1ccc(NC(=O)c2ccco2)s1 to have a higher LogP value.,CN(C)c1ncccc1NC(=O)c1ccc(NC(=O)c2ccco2)s1,3.306700000000001
144382,Please optimize the molecule CC(C)[C@@H]1C[C@H](C(F)(F)F)n2nc([C@H]3CC[NH+](CC(N)=O)C3)cc2N1 to have a higher LogP value.,CC(C)[C@@H]1C[C@H](C(F)(F)F)n2nc([C@H]3CC[NH+](CC(N)=O)C3)cc2N1,0.684200000000001
213849,Please modify the molecule C[C@@H]1OCC[C@@H]1C(=O)N1CC(C)(O)C1 to decrease its LogP value.,C[C@@H]1OCC[C@@H]1C(=O)N1CC(C)(O)C1,0.004599999999999993
201424,Modify the molecule CCCS(=O)(=O)[N-]c1ccc(Nc2nccn(CC)c2=O)cc1 to have a higher LogP value.,CCCS(=O)(=O)[N-]c1ccc(Nc2nccn(CC)c2=O)cc1,2.751800000000001
203647,Optimize the molecule C(=N/Nc1nc(Nc2ccccc2)nc(N2CCCC2)n1)\c1cccnc1 to have a lower LogP value.,C(=N/Nc1nc(Nc2ccccc2)nc(N2CCCC2)n1)\c1cccnc1,3.056400000000001
194124,Modify the molecule CCc1ccccc1NC(=O)CNC(=O)N[C@H](c1ccc(Cl)cc1)C1CC1 to increase its LogP value.,CCc1ccccc1NC(=O)CNC(=O)N[C@H](c1ccc(Cl)cc1)C1CC1,4.291400000000003
232513,Modify the molecule O=C(CCCC[C@H]1CCSS1)N[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,O=C(CCCC[C@H]1CCSS1)N[C@@H]1CCS(=O)(=O)C1,2.0038
7669,Modify the molecule CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O to have a lower LogP value.,CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O,1.8552999999999988
61967,Optimize the molecule CCOc1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4ccccc4)N3C2=O)cc1 to have a lower LogP value.,CCOc1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4ccccc4)N3C2=O)cc1,1.3008000000000004
185999,Optimize the molecule COc1cccc(C(=O)[C@@H]2CCC[NH+](Cc3nc(-c4cccs4)oc3C)C2)c1 to have a lower LogP value.,COc1cccc(C(=O)[C@@H]2CCC[NH+](Cc3nc(-c4cccs4)oc3C)C2)c1,3.397920000000002
103901,Please optimize the molecule CCO[C@@H]1C[C@@H]1C(=O)NCc1ccc(OC)c(F)c1 to have a lower LogP value.,CCO[C@@H]1C[C@@H]1C(=O)NCc1ccc(OC)c(F)c1,1.8755
82142,Modify the molecule Cc1ccc(C(C)C)c2c1[C@@H]([NH2+][C@@H]1CCCN(c3cccnn3)C1)CCO2 to have a higher LogP value.,Cc1ccc(C(C)C)c2c1[C@@H]([NH2+][C@@H]1CCCN(c3cccnn3)C1)CCO2,2.9644200000000014
30377,Modify the molecule Clc1ccc2c(N3CC[NH+](Cc4csc5ccccc45)CC3)ncnc2c1 to increase its LogP value.,Clc1ccc2c(N3CC[NH+](Cc4csc5ccccc45)CC3)ncnc2c1,3.4030000000000022
239811,Modify the molecule O=C(C[NH+]1CCCCC1)N[C@H]1CC(=O)N(Cc2cccc(F)c2)C1 to have a higher LogP value.,O=C(C[NH+]1CCCCC1)N[C@H]1CC(=O)N(Cc2cccc(F)c2)C1,0.11160000000000103
75630,Please optimize the molecule CCC1(CC)CCN(C(=O)NC(=O)CCl)C1 to have a lower LogP value.,CCC1(CC)CCN(C(=O)NC(=O)CCl)C1,1.9734999999999998
46431,Optimize the molecule Cc1cc(C)cc(NC(=O)CSc2nnc(NCc3ccccc3)s2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=O)CSc2nnc(NCc3ccccc3)s2)c1,4.497840000000004
237597,Modify the molecule C[C@H](C[NH2+]C1CCCC1)[NH+]1CCC(C)(C)C1 to have a higher LogP value.,C[C@H](C[NH2+]C1CCCC1)[NH+]1CCC(C)(C)C1,0.1957000000000011
69198,Please optimize the molecule O=C(CSc1ncn[nH]1)N1CCc2ccccc2C1 to have a higher LogP value.,O=C(CSc1ncn[nH]1)N1CCc2ccccc2C1,1.4816999999999998
98978,Modify the molecule O=C(NCc1ccncc1)Nc1ccc(Cl)c([N+](=O)[O-])c1 to have a higher LogP value.,O=C(NCc1ccncc1)Nc1ccc(Cl)c([N+](=O)[O-])c1,2.964900000000001
214380,Please modify the molecule C/C=C/C[NH+](CCC)CC1CC[NH2+]CC1 to decrease its LogP value.,C/C=C/C[NH+](CCC)CC1CC[NH2+]CC1,-0.16919999999999735
146748,Modify the molecule CSc1nccc(NC[C@@H]2CCCC[NH2+]2)n1 to have a higher LogP value.,CSc1nccc(NC[C@@H]2CCCC[NH2+]2)n1,0.7262999999999997
129369,Modify the molecule C[C@H]1C[C@@H]1C(=O)NCCC1CCCCC1 to decrease its LogP value.,C[C@H]1C[C@@H]1C(=O)NCCC1CCCCC1,2.729000000000001
82584,Optimize the molecule Cc1ccc(C(=O)N2CCCCC[C@H]2c2ccco2)c(C)n1 to have a higher LogP value.,Cc1ccc(C(=O)N2CCCCC[C@H]2c2ccco2)c(C)n1,4.048940000000003
137306,Optimize the molecule COc1ccc(NC(=O)/C(C#N)=C/c2cccc(O)c2)cc1Cl to have a lower LogP value.,COc1ccc(NC(=O)/C(C#N)=C/c2cccc(O)c2)cc1Cl,3.5998800000000015
248601,Please optimize the molecule O=C(NCc1ccc(Cl)nc1)c1c[nH]nc1-c1ccccc1 to have a higher LogP value.,O=C(NCc1ccc(Cl)nc1)c1c[nH]nc1-c1ccccc1,3.0551000000000013
18165,Modify the molecule C[C@H]1C[C@H](NC(=O)Cn2ccnc2)CN1c1ccccc1 to decrease its LogP value.,C[C@H]1C[C@H](NC(=O)Cn2ccnc2)CN1c1ccccc1,1.666699999999999
177121,Please modify the molecule C[C@H]1CCC[C@@]1(O)C1(C#N)CCCCC1 to decrease its LogP value.,C[C@H]1CCC[C@@]1(O)C1(C#N)CCCCC1,3.0115800000000013
109817,Please optimize the molecule CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O to have a higher LogP value.,CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O,1.62882
236141,Please optimize the molecule O=C(NC1CC[NH+](Cc2ccc(F)c(F)c2)CC1)[C@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,O=C(NC1CC[NH+](Cc2ccc(F)c(F)c2)CC1)[C@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2,2.8357
241592,Optimize the molecule O=C(c1ccc(F)cc1Br)N1CCO[C@H](c2ccc(F)cc2)C1 to have a lower LogP value.,O=C(c1ccc(F)cc1Br)N1CCO[C@H](c2ccc(F)cc2)C1,3.9410000000000025
198831,Modify the molecule C[C@@H]1c2cccn2CCN1S(=O)(=O)c1ccc2c(c1)oc(=O)n2C to decrease its LogP value.,C[C@@H]1c2cccn2CCN1S(=O)(=O)c1ccc2c(c1)oc(=O)n2C,1.6985000000000001
187128,Please optimize the molecule Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1 to have a higher LogP value.,Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1,3.4419200000000023
87536,Optimize the molecule Cc1c(Cl)ccc2sc(NC(=O)[C@@H]3CCCN(S(C)(=O)=O)C3)nc12 to have a higher LogP value.,Cc1c(Cl)ccc2sc(NC(=O)[C@@H]3CCCN(S(C)(=O)=O)C3)nc12,2.868220000000001
26813,Please optimize the molecule C[C@H]1CCc2c(sc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2C(N)=O)C1 to have a lower LogP value.,C[C@H]1CCc2c(sc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2C(N)=O)C1,4.171800000000003
61465,Modify the molecule CCOC(=O)c1c(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)sc2c1CCC2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)sc2c1CCC2,2.995120000000002
75166,Please modify the molecule C/C=C(/C)C(=O)O[C@@H]1CCC[C@H]1n1cccn1 to decrease its LogP value.,C/C=C(/C)C(=O)O[C@@H]1CCC[C@H]1n1cccn1,2.4861000000000004
98693,Please modify the molecule CCCOc1cccc(NC(=O)[C@H]2CC(=O)N(C)C2)c1 to decrease its LogP value.,CCCOc1cccc(NC(=O)[C@H]2CC(=O)N(C)C2)c1,1.8921999999999999
233703,Modify the molecule C[C@H](CCc1ccccc1)CC(=O)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F to decrease its LogP value.,C[C@H](CCc1ccccc1)CC(=O)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F,4.258100000000003
34999,Please optimize the molecule CC[C@@H](C)C(=O)N1CCC[C@H](C(=O)Nc2nc(-c3ccc(C)s3)c(C)s2)C1 to have a higher LogP value.,CC[C@@H](C)C(=O)N1CCC[C@H](C(=O)Nc2nc(-c3ccc(C)s3)c(C)s2)C1,4.711640000000004
121670,Modify the molecule C[C@H]1CN(Cc2ccc(O)c(N)c2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CN(Cc2ccc(O)c(N)c2)C[C@H](C)O1,1.5836000000000001
112714,Modify the molecule Cc1ccccc1-c1cccc(C[NH+]2CCC[C@@H](c3ccn[nH]3)C2)c1 to decrease its LogP value.,Cc1ccccc1-c1cccc(C[NH+]2CCC[C@@H](c3ccn[nH]3)C2)c1,3.347620000000001
208629,Please optimize the molecule O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1CCCN(C2=NS(=O)(=O)c3ccccc32)C1 to have a lower LogP value.,O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1CCCN(C2=NS(=O)(=O)c3ccccc32)C1,3.0413000000000014
207209,Please optimize the molecule Cc1noc([C@H](C)OC(=O)[C@@H]2C[C@@H]2C)n1 to have a lower LogP value.,Cc1noc([C@H](C)OC(=O)[C@@H]2C[C@@H]2C)n1,1.63822
177983,Modify the molecule CCOC(=O)c1cccc(OC(=O)C[C@@H]2C=CCC2)c1 to increase its LogP value.,CCOC(=O)c1cccc(OC(=O)C[C@@H]2C=CCC2)c1,3.1250000000000018
195973,Optimize the molecule Cc1nc2n(n1)[C@H](c1ccc3c(c1)OCCCO3)C1=C(C[C@@H](c3ccco3)CC1=O)N2 to have a higher LogP value.,Cc1nc2n(n1)[C@H](c1ccc3c(c1)OCCCO3)C1=C(C[C@@H](c3ccco3)CC1=O)N2,3.756520000000002
145700,Modify the molecule C[NH+]1CCCC[C@@H]1C(=O)N[C@H](CO)Cc1c[nH]c2ccccc12 to increase its LogP value.,C[NH+]1CCCC[C@@H]1C(=O)N[C@H](CO)Cc1c[nH]c2ccccc12,0.25470000000000154
158228,Optimize the molecule COCCN(C(=O)[C@H]1CC[NH2+][C@@H]1C)[C@@H](C)C1CC1 to have a lower LogP value.,COCCN(C(=O)[C@H]1CC[NH2+][C@@H]1C)[C@@H](C)C1CC1,0.23170000000000202
31210,Modify the molecule CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1 to increase its LogP value.,CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1,2.616200000000001
26251,Optimize the molecule O=C(CCc1ccc(O)cc1)N/N=C\c1cc(Cl)cc(Cl)c1O to have a higher LogP value.,O=C(CCc1ccc(O)cc1)N/N=C\c1cc(Cl)cc(Cl)c1O,3.487500000000001
1923,Modify the molecule COc1ccc2nc(-c3ccc(Cl)c(NC(=O)NCc4ccccc4)c3)cn2n1 to increase its LogP value.,COc1ccc2nc(-c3ccc(Cl)c(NC(=O)NCc4ccccc4)c3)cn2n1,4.3800000000000034
205272,Please optimize the molecule Cn1ccnc1-c1nccn1C(c1ccccc1)c1ccccc1 to have a higher LogP value.,Cn1ccnc1-c1nccn1C(c1ccccc1)c1ccccc1,3.9213000000000022
173964,Please modify the molecule Cc1ccc(CNC(=O)CSc2nnc3n(CC(C)C)c(=O)c4sccc4n23)cc1 to increase its LogP value.,Cc1ccc(CNC(=O)CSc2nnc3n(CC(C)C)c(=O)c4sccc4n23)cc1,3.478620000000002
103611,Modify the molecule O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C(=O)N1CNc1ccccc1C(F)(F)F to increase its LogP value.,O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C(=O)N1CNc1ccccc1C(F)(F)F,2.881900000000001
19314,Modify the molecule Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1 to decrease its LogP value.,Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1,3.1321400000000015
144947,Optimize the molecule COCc1cc([N+](=O)[O-])ccc1NCc1ccc2c(c1)OCCCO2 to have a higher LogP value.,COCc1cc([N+](=O)[O-])ccc1NCc1ccc2c(c1)OCCCO2,3.5146000000000024
103709,Modify the molecule COc1ccccc1NC(=O)COc1cccc(-c2noc(-c3ccc(F)cc3)n2)c1 to have a higher LogP value.,COc1ccccc1NC(=O)COc1cccc(-c2noc(-c3ccc(F)cc3)n2)c1,4.568800000000003
209754,Please modify the molecule Cc1nonc1CN(C)C(=O)c1cc(-c2cccs2)nn1C to decrease its LogP value.,Cc1nonc1CN(C)C(=O)c1cc(-c2cccs2)nn1C,2.1122199999999998
78979,Optimize the molecule CC/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(C)cc1 to have a lower LogP value.,CC/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(C)cc1,4.029020000000004
162474,Optimize the molecule CC(C)c1cccc2c1OCC[C@@H]2[NH2+]C[C@]1(O)CCOC1 to have a higher LogP value.,CC(C)c1cccc2c1OCC[C@@H]2[NH2+]C[C@]1(O)CCOC1,1.3483999999999998
2774,Modify the molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 to decrease its LogP value.,CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1,1.8629
85643,Please optimize the molecule CC(=O)N/N=C(\C)CC(=O)Nc1ccc(Cl)cc1Cl to have a lower LogP value.,CC(=O)N/N=C(\C)CC(=O)Nc1ccc(Cl)cc1Cl,2.8340000000000005
77755,Modify the molecule C[C@H](NC(=O)COc1cccc2c1OC(C)(C)C2)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)COc1cccc2c1OC(C)(C)C2)C1CC1,2.693600000000001
163221,Please optimize the molecule COCCOc1ncccc1C(=O)Nc1c(F)cc(F)cc1F to have a lower LogP value.,COCCOc1ncccc1C(=O)Nc1c(F)cc(F)cc1F,2.7764000000000006
174250,Please optimize the molecule COc1cccc2cc(C(=O)C3=C([O-])C(=O)N(c4cc(C)on4)[C@H]3c3ccc(F)cc3)oc12 to have a higher LogP value.,COc1cccc2cc(C(=O)C3=C([O-])C(=O)N(c4cc(C)on4)[C@H]3c3ccc(F)cc3)oc12,3.4621200000000023
62891,Modify the molecule C[C@H](O)[C@@H]1CCCC[NH+]1Cc1coc(-c2ccc(S(C)(=O)=O)cc2)n1 to have a lower LogP value.,C[C@H](O)[C@@H]1CCCC[NH+]1Cc1coc(-c2ccc(S(C)(=O)=O)cc2)n1,1.0632999999999997
34265,Modify the molecule C=CCN(C(=O)[C@H](CC)c1ccccc1)c1nnc(-c2ccncc2)s1 to decrease its LogP value.,C=CCN(C(=O)[C@H](CC)c1ccccc1)c1nnc(-c2ccncc2)s1,4.3129000000000035
235885,Modify the molecule Cc1cccc(-c2nnc(SCC(=O)Nc3cccc(C(F)(F)F)c3)n2N)c1 to decrease its LogP value.,Cc1cccc(-c2nnc(SCC(=O)Nc3cccc(C(F)(F)F)c3)n2N)c1,3.716920000000001
30008,Please optimize the molecule O=C(C[C@@H]1CCCc2ccccc2[C@@H]1O)NCCO to have a higher LogP value.,O=C(C[C@@H]1CCCc2ccccc2[C@@H]1O)NCCO,1.1710999999999998
69312,Optimize the molecule C[C@]1([C@@H](O)Cc2cccs2)CCCO1 to have a lower LogP value.,C[C@]1([C@@H](O)Cc2cccs2)CCCO1,2.2206
194493,Modify the molecule Nc1c(S(=O)(=O)c2ccccc2)cnn1S(=O)(=O)c1ccc(Cl)cc1 to increase its LogP value.,Nc1c(S(=O)(=O)c2ccccc2)cnn1S(=O)(=O)c1ccc(Cl)cc1,2.1885000000000003
187465,Optimize the molecule CC(=O)N[C@H](c1ccccn1)C1CC[NH+](Cc2cccc(OC(C)C)c2)CC1 to have a lower LogP value.,CC(=O)N[C@H](c1ccccn1)C1CC[NH+](Cc2cccc(OC(C)C)c2)CC1,2.5411
215635,Modify the molecule O=C(CCN1CCCC1=O)NCC[C@@H](O)c1ccccc1 to decrease its LogP value.,O=C(CCN1CCCC1=O)NCC[C@@H](O)c1ccccc1,1.2387999999999997
238819,Please modify the molecule Cc1cc(C)n(Cc2nnc(C)n2C2CC2)n1 to increase its LogP value.,Cc1cc(C)n(Cc2nnc(C)n2C2CC2)n1,1.7830599999999999
179775,Modify the molecule CC(C)(C)n1nc2c(c1-n1cccc1)CN(C(=O)[C@@H]1COc3ccccc3O1)C2 to decrease its LogP value.,CC(C)(C)n1nc2c(c1-n1cccc1)CN(C(=O)[C@@H]1COc3ccccc3O1)C2,3.1110000000000015
245768,Please optimize the molecule Cc1nc(C(C)(C)C)sc1[C@H](C)[NH2+][C@H](CO)C(C)C to have a higher LogP value.,Cc1nc(C(C)(C)C)sc1[C@H](C)[NH2+][C@H](CO)C(C)C,2.39032
202507,Modify the molecule C[C@H](OC(=O)c1ccc2c(c1)C(=O)N(Cc1ccco1)C2=O)C(=O)NC1CCCCC1 to have a higher LogP value.,C[C@H](OC(=O)c1ccc2c(c1)C(=O)N(Cc1ccco1)C2=O)C(=O)NC1CCCCC1,3.070000000000002
35975,Modify the molecule CS(=O)(=O)NC1CCC([NH2+][C@H]2CCCc3ccccc32)CC1 to have a higher LogP value.,CS(=O)(=O)NC1CCC([NH2+][C@H]2CCCc3ccccc32)CC1,1.4878
95183,Optimize the molecule COc1cc(/C=C/C(=O)N(C)CCOc2ccc(Cl)cc2)cc2c1OCCO2 to have a higher LogP value.,COc1cc(/C=C/C(=O)N(C)CCOc2ccc(Cl)cc2)cc2c1OCCO2,3.6704000000000025
49300,Please optimize the molecule CCS(=O)(=O)c1ccc(-c2cccc(NC(=O)c3cc(Cl)ccc3OC)c2)nn1 to have a lower LogP value.,CCS(=O)(=O)c1ccc(-c2cccc(NC(=O)c3cc(Cl)ccc3OC)c2)nn1,3.8515000000000024
221589,Modify the molecule Cc1ccccc1-n1ccnc1SC[C@@H](O)CN1CCOCC1 to increase its LogP value.,Cc1ccccc1-n1ccnc1SC[C@@H](O)CN1CCOCC1,1.9659199999999997
48337,Optimize the molecule O=C(NCCSc1ccccc1)NCCC(=O)N1CCCC1 to have a lower LogP value.,O=C(NCCSc1ccccc1)NCCC(=O)N1CCCC1,2.0904
185482,Modify the molecule CCc1[nH+]c(C)cn1Cc1nc(-c2ccc3c(c2)OCO3)no1 to have a higher LogP value.,CCc1[nH+]c(C)cn1Cc1nc(-c2ccc3c(c2)OCO3)no1,2.0000199999999997
210842,Modify the molecule CC(C)Cn1nccc1NC(=O)C[C@@H]1C=CCC1 to increase its LogP value.,CC(C)Cn1nccc1NC(=O)C[C@@H]1C=CCC1,2.8339000000000016
48905,Optimize the molecule C[C@@H]1CCCN(C(=O)NCC(C)(C)c2ccncc2)CC1 to have a lower LogP value.,C[C@@H]1CCCN(C(=O)NCC(C)(C)c2ccncc2)CC1,3.190800000000002
191345,Please optimize the molecule Cn1c(=O)n(Cc2ccc(Cl)cc2)c(=O)c2c1nc1n2CCN1c1ccccc1 to have a lower LogP value.,Cn1c(=O)n(Cc2ccc(Cl)cc2)c(=O)c2c1nc1n2CCN1c1ccccc1,2.7501000000000007
172615,Modify the molecule CC(=O)c1ccc(-c2ccc(/C=N/[NH+]=C3/CCCCCN3)o2)cc1 to decrease its LogP value.,CC(=O)c1ccc(-c2ccc(/C=N/[NH+]=C3/CCCCCN3)o2)cc1,2.1258
48762,Please optimize the molecule COc1cc(C(=O)N2Cc3cc4ccccc4nc3[C@@H]2C)cc(OC)c1OC to have a higher LogP value.,COc1cc(C(=O)N2Cc3cc4ccccc4nc3[C@@H]2C)cc(OC)c1OC,3.9776000000000034
207118,Please modify the molecule Cc1cc(C)cc(NC(=O)CNc2cc3c(cc2Cl)NC(=O)CO3)c1 to decrease its LogP value.,Cc1cc(C)cc(NC(=O)CNc2cc3c(cc2Cl)NC(=O)CO3)c1,3.3383400000000005
149222,Please modify the molecule Cc1cccc(N2CCN(c3ncnc(NCCCN4CCOCC4)c3N)CC2)c1C to decrease its LogP value.,Cc1cccc(N2CCN(c3ncnc(NCCCN4CCOCC4)c3N)CC2)c1C,2.1364400000000003
183445,Modify the molecule Cn1ncc(N2CCO[C@@H](CCNc3nnc(C4CC4)o3)C2)cc1=O to increase its LogP value.,Cn1ncc(N2CCO[C@@H](CCNc3nnc(C4CC4)o3)C2)cc1=O,0.7480999999999993
14777,Please modify the molecule COc1ccc(CCNC(=O)c2cc(-c3ccco3)on2)cc1OC to increase its LogP value.,COc1ccc(CCNC(=O)c2cc(-c3ccco3)on2)cc1OC,2.9243000000000015
11861,Please modify the molecule O=C(C[NH+](Cc1ccco1)[C@H]1CCS(=O)(=O)C1)Nc1ccc(Br)cc1F to increase its LogP value.,O=C(C[NH+](Cc1ccco1)[C@H]1CCS(=O)(=O)C1)Nc1ccc(Br)cc1F,1.3919000000000004
210791,Modify the molecule C[C@@H]1CN(C(=O)Nc2cccc(C(F)(F)F)c2)c2ccccc2S1 to have a lower LogP value.,C[C@@H]1CN(C(=O)Nc2cccc(C(F)(F)F)c2)c2ccccc2S1,5.238100000000003
92698,Modify the molecule CCC[NH+]1CC[C@H](CNC(=O)Nc2cc(-c3ccccc3)nn2C(C)C)C1 to have a lower LogP value.,CCC[NH+]1CC[C@H](CNC(=O)Nc2cc(-c3ccccc3)nn2C(C)C)C1,2.5672999999999995
98506,Modify the molecule NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1 to have a lower LogP value.,NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1,0.3362999999999998
39159,Please modify the molecule COc1ccc(-c2cc3nc(C)c(C)c(NCCN4CCOCC4)n3n2)cc1 to decrease its LogP value.,COc1ccc(-c2cc3nc(C)c(C)c(NCCN4CCOCC4)n3n2)cc1,2.7658400000000007
131283,Modify the molecule Cc1ccc(C[NH+]2CCC(CNC(=O)Nc3cccc(Br)c3)CC2)cc1 to decrease its LogP value.,Cc1ccc(C[NH+]2CCC(CNC(=O)Nc3cccc(Br)c3)CC2)cc1,3.3741200000000013
106680,Please optimize the molecule CCc1ccc(NC(=O)[C@@H](NC(=O)N2C[C@@H]3C[C@H](C2)Cn2c3cccc2=O)C(C)C)cc1 to have a lower LogP value.,CCc1ccc(NC(=O)[C@@H](NC(=O)N2C[C@@H]3C[C@H](C2)Cn2c3cccc2=O)C(C)C)cc1,3.202700000000002
150933,Modify the molecule CCc1cnc(C[NH+](C2CC2)[C@H](C)C2CC2)o1 to increase its LogP value.,CCc1cnc(C[NH+](C2CC2)[C@H](C)C2CC2)o1,1.5827999999999995
222939,Modify the molecule COC(=O)[C@@H](NC(=O)Cc1ccc(C)o1)c1ccc(Cl)c(F)c1 to have a higher LogP value.,COC(=O)[C@@H](NC(=O)Cc1ccc(C)o1)c1ccc(Cl)c(F)c1,2.953520000000001
218932,Please modify the molecule C[NH2+]Cc1cc(F)c(O[C@H]2CCCC[C@H]2O)c(F)c1 to increase its LogP value.,C[NH2+]Cc1cc(F)c(O[C@H]2CCCC[C@H]2O)c(F)c1,1.3403000000000003
48061,Optimize the molecule Cc1ccc(NCc2ccccc2Br)c(C)n1 to have a higher LogP value.,Cc1ccc(NCc2ccccc2Br)c(C)n1,4.073040000000002
79874,Optimize the molecule CCOc1ccc(NC(=O)CN2CCCCCCC2=O)c(C(F)(F)F)c1 to have a lower LogP value.,CCOc1ccc(NC(=O)CN2CCCCCCC2=O)c(C(F)(F)F)c1,3.835300000000003
246144,Please optimize the molecule CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)OC[C@H]1CCCO1 to have a lower LogP value.,CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)OC[C@H]1CCCO1,2.816600000000001
163381,Please optimize the molecule CCOc1ccc(NC(=O)[C@H]2C=C[C@@H]([NH3+])C2)cc1CO to have a higher LogP value.,CCOc1ccc(NC(=O)[C@H]2C=C[C@@H]([NH3+])C2)cc1CO,0.7026999999999999
97745,Please optimize the molecule CCc1cc(=O)oc2cc(O[C@H](C)C(=O)N3CC[C@@]4(O)CCCC[C@@H]4C3)ccc12 to have a lower LogP value.,CCc1cc(=O)oc2cc(O[C@H](C)C(=O)N3CC[C@@]4(O)CCCC[C@@H]4C3)ccc12,3.2763000000000018
164485,Modify the molecule CCOC(=O)C(=O)Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 to increase its LogP value.,CCOC(=O)C(=O)Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1,1.2649999999999997
202579,Modify the molecule CCn1cc[nH+]c1CN1CCN(Cc2ncc(C(C)(C)C)o2)C[C@@H]1C to decrease its LogP value.,CCn1cc[nH+]c1CN1CCN(Cc2ncc(C(C)(C)C)o2)C[C@@H]1C,2.3139000000000003
166879,Modify the molecule Cc1ccn(-c2cnc(Br)cn2)n1 to have a lower LogP value.,Cc1ccn(-c2cnc(Br)cn2)n1,1.7332199999999998
205751,Modify the molecule CCC[NH+]1CCC(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CC1 to have a higher LogP value.,CCC[NH+]1CCC(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CC1,1.384900000000001
155628,Optimize the molecule COC(=O)[C@H](c1ccc(Cl)cc1)N1CCN(C(=O)Nc2ccccc2)CC1 to have a higher LogP value.,COC(=O)[C@H](c1ccc(Cl)cc1)N1CCN(C(=O)Nc2ccccc2)CC1,3.4038000000000013
14603,Please modify the molecule CC[NH+](CC)CCn1/c(=N/C(=O)C2CCCC2)[nH]c2ccccc21 to decrease its LogP value.,CC[NH+](CC)CCn1/c(=N/C(=O)C2CCCC2)[nH]c2ccccc21,1.5116
180248,Modify the molecule Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCOC2)n1 to decrease its LogP value.,Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCOC2)n1,-1.4386799999999973
199120,Please optimize the molecule COCc1c(C(=O)NCc2ccccc2Cl)nnn1-c1cccc(C)c1 to have a lower LogP value.,COCc1c(C(=O)NCc2ccccc2Cl)nnn1-c1cccc(C)c1,3.3055200000000022
135616,Please modify the molecule C/C(=C\c1ccccc1[N+](=O)[O-])C[NH2+]C(C)C to decrease its LogP value.,C/C(=C\c1ccccc1[N+](=O)[O-])C[NH2+]C(C)C,1.9699
48451,Optimize the molecule CN(C)NC(=O)c1ccsc1NC(=O)Cc1ccccc1 to have a lower LogP value.,CN(C)NC(=O)c1ccsc1NC(=O)Cc1ccccc1,2.1357
182051,Modify the molecule COc1cccc(OCc2ccc(C(N)=O)cc2N)c1 to have a lower LogP value.,COc1cccc(OCc2ccc(C(N)=O)cc2N)c1,1.9553
161584,Modify the molecule Cc1ccccc1[C@H]1Nc2ccc(S(N)(=O)=O)cc2[C@@H]2C=CC[C@@H]12 to decrease its LogP value.,Cc1ccccc1[C@H]1Nc2ccc(S(N)(=O)=O)cc2[C@@H]2C=CC[C@@H]12,3.4689200000000016
165341,Optimize the molecule CCc1cccc2c(CCNC(=O)Cc3ccc(C)c(O)c3)c[nH]c12 to have a higher LogP value.,CCc1cccc2c(CCNC(=O)Cc3ccc(C)c(O)c3)c[nH]c12,3.6457200000000016
10337,Modify the molecule C[C@H]([NH2+]C1CCC(O)CC1)c1ccccc1O to decrease its LogP value.,C[C@H]([NH2+]C1CCC(O)CC1)c1ccccc1O,1.3200999999999994
228233,Modify the molecule COCc1csc(NC(=O)NC[C@@](C)(O)c2ccc(F)cc2)n1 to have a lower LogP value.,COCc1csc(NC(=O)NC[C@@](C)(O)c2ccc(F)cc2)n1,2.4578000000000007
57926,Modify the molecule Fc1cc(Oc2ncnc3c2CCCCC3)ccc1Br to increase its LogP value.,Fc1cc(Oc2ncnc3c2CCCCC3)ccc1Br,4.439400000000003
142746,Optimize the molecule Cc1ccc(S(=O)(=O)N(C)C(C)C)cc1NCc1ccc(C#N)cc1 to have a higher LogP value.,Cc1ccc(S(=O)(=O)N(C)C(C)C)cc1NCc1ccc(C#N)cc1,3.5077000000000025
162941,Optimize the molecule CC(C)(CNC(=O)NC[C@@H]1CC=CCC1)NC(=O)OC(C)(C)C to have a higher LogP value.,CC(C)(CNC(=O)NC[C@@H]1CC=CCC1)NC(=O)OC(C)(C)C,2.9452000000000016
101087,Modify the molecule CCc1nn(C)c(OC)c1CN1CCC[NH+](CC2CCCCC2)CC1 to have a lower LogP value.,CCc1nn(C)c(OC)c1CN1CCC[NH+](CC2CCCCC2)CC1,1.6620000000000006
65939,Modify the molecule O=C(NC[C@@H](c1ccccc1)[NH+]1CCCC1)c1ccc(C2SCCCS2)cc1 to decrease its LogP value.,O=C(NC[C@@H](c1ccccc1)[NH+]1CCCC1)c1ccc(C2SCCCS2)cc1,3.7051000000000025
200835,Please modify the molecule CN(Cc1nnc(C2CC2)n1C)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 to increase its LogP value.,CN(Cc1nnc(C2CC2)n1C)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,-0.10049999999999804
232069,Modify the molecule COc1ccc(CC(=O)NCC2CCN(C(=O)c3cc4ccccc4o3)CC2)cc1OC to increase its LogP value.,COc1ccc(CC(=O)NCC2CCN(C(=O)c3cc4ccccc4o3)CC2)cc1OC,3.661100000000003
109649,Optimize the molecule CC[NH2+][C@@H](C(OC)OC)[C@H]1CCOC2(CCC2)C1 to have a lower LogP value.,CC[NH2+][C@@H](C(OC)OC)[C@H]1CCOC2(CCC2)C1,0.906500000000001
219299,Please optimize the molecule C[NH2+][C@H](Cc1ccncc1)[C@@H]1CCOC2(CCSCC2)C1 to have a higher LogP value.,C[NH2+][C@H](Cc1ccncc1)[C@@H]1CCOC2(CCSCC2)C1,1.8783000000000005
31882,Modify the molecule Cc1c(C(=O)NCC(F)(F)F)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(C(=O)NCC(F)(F)F)cccc1[N+](=O)[O-],2.1953199999999997
72663,Please optimize the molecule Cn1c(=O)oc2cc([C@H](Br)C3C(C)(C)C3(C)C)ccc21 to have a higher LogP value.,Cn1c(=O)oc2cc([C@H](Br)C3C(C)(C)C3(C)C)ccc21,4.249700000000003
185787,Optimize the molecule CN1CCO[C@@H](CNC(=O)CC[C@H]([NH3+])c2ccccc2)C1 to have a lower LogP value.,CN1CCO[C@@H](CNC(=O)CC[C@H]([NH3+])c2ccccc2)C1,0.19660000000000277
168629,Optimize the molecule CCCCCC(=O)Nc1cccc(-c2nn3c(CC)nnc3s2)c1 to have a higher LogP value.,CCCCCC(=O)Nc1cccc(-c2nn3c(CC)nnc3s2)c1,3.934000000000003
23332,Please optimize the molecule CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1 to have a lower LogP value.,CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1,1.87842
202279,Modify the molecule CC[C@@H](CC#N)N[C@@H]1CC[NH2+]C1 to have a lower LogP value.,CC[C@@H](CC#N)N[C@@H]1CC[NH2+]C1,-0.39601999999999915
151359,Optimize the molecule O=C(Nc1n[nH]c2ccc([N+](=O)[O-])cc12)[C@H]1CC(=O)N(CC2CC2)C1 to have a higher LogP value.,O=C(Nc1n[nH]c2ccc([N+](=O)[O-])cc12)[C@H]1CC(=O)N(CC2CC2)C1,1.6680999999999997
194962,Optimize the molecule CCCC[C@H](C)n1c([C@H](C)Cl)nc2c(CCC)nn(C)c21 to have a higher LogP value.,CCCC[C@H](C)n1c([C@H](C)Cl)nc2c(CCC)nn(C)c21,4.773300000000004
19535,Modify the molecule CN(C)C(=O)C[NH+]1CCCN(C(=O)c2ccc(-n3cccc3)cc2)CC1 to have a lower LogP value.,CN(C)C(=O)C[NH+]1CCCN(C(=O)c2ccc(-n3cccc3)cc2)CC1,0.2963000000000027
8390,Please modify the molecule O=C(Nc1ccc2c(c1)OCCCO2)c1ccc([N+](=O)[O-])o1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)OCCCO2)c1ccc([N+](=O)[O-])o1,2.601400000000001
172856,Modify the molecule CC1(C)C(C(=O)N2CCN(c3ncccc3C(N)=O)CC2)C1(C)C to have a lower LogP value.,CC1(C)C(C(=O)N2CCN(c3ncccc3C(N)=O)CC2)C1(C)C,1.5112999999999999
148899,Modify the molecule Cc1ncsc1[C@H](C)N[C@@H]1CCC[C@@H]1c1ccc(F)cc1 to have a higher LogP value.,Cc1ncsc1[C@H](C)N[C@@H]1CCC[C@@H]1c1ccc(F)cc1,4.577520000000004
240138,Please optimize the molecule CCOc1cc(C#N)ccc1OC(=O)Cc1cn2ccsc2n1 to have a lower LogP value.,CCOc1cc(C#N)ccc1OC(=O)Cc1cn2ccsc2n1,2.814280000000001
170531,Optimize the molecule CCOC(=O)[C@H]1CCCN(c2ncnc(N3CCOCC3)c2N)C1 to have a lower LogP value.,CCOC(=O)[C@H]1CCCN(c2ncnc(N3CCOCC3)c2N)C1,0.6749000000000004
158811,Modify the molecule COc1cccc(OC)c1C(=O)N1CCN(Cc2csc(-c3ccccc3)n2)CC1 to decrease its LogP value.,COc1cccc(OC)c1C(=O)N1CCN(Cc2csc(-c3ccccc3)n2)CC1,3.785300000000003
172120,Modify the molecule Cc1cc(NC(=O)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1OC(C)C to decrease its LogP value.,Cc1cc(NC(=O)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1OC(C)C,2.40442
141406,Please optimize the molecule CC(C)[NH+](Cc1cc(F)ccc1Br)C1CCOCC1 to have a higher LogP value.,CC(C)[NH+](Cc1cc(F)ccc1Br)C1CCOCC1,2.5605
196293,Please modify the molecule CC(C)C[C@H]1NC(=O)OC1(c1ccccc1)c1ccccc1 to increase its LogP value.,CC(C)C[C@H]1NC(=O)OC1(c1ccccc1)c1ccccc1,4.084700000000003
117849,Modify the molecule CNc1ncnc2c1[nH]c1ccccc12 to increase its LogP value.,CNc1ncnc2c1[nH]c1ccccc12,2.1528
121842,Modify the molecule CCCCNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1 to have a higher LogP value.,CCCCNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1,1.7053999999999998
5437,Please modify the molecule CCN1C(=O)/C(=C/c2c(C)c(C#N)c(=O)n(C)c2N2CCCC2)SC1=S to decrease its LogP value.,CCN1C(=O)/C(=C/c2c(C)c(C#N)c(=O)n(C)c2N2CCCC2)SC1=S,2.3867000000000003
91016,Please modify the molecule CN(c1ccc(C(=O)[O-])cc1[N+](=O)[O-])C1CC1 to increase its LogP value.,CN(c1ccc(C(=O)[O-])cc1[N+](=O)[O-])C1CC1,0.5568999999999997
153207,Please optimize the molecule C[C@H](NC(=O)N(C)C1CCC1)c1ccc(N2CCOCC2)cc1 to have a lower LogP value.,C[C@H](NC(=O)N(C)C1CCC1)c1ccc(N2CCOCC2)cc1,2.778100000000001
198435,Modify the molecule Cc1ncccc1-c1nn(C)c(N)c1-c1cccc(Cl)c1 to increase its LogP value.,Cc1ncccc1-c1nn(C)c(N)c1-c1cccc(Cl)c1,3.6931200000000013
88843,Please modify the molecule CCS(=O)(=O)NC[C@H](C)Oc1ccccc1 to increase its LogP value.,CCS(=O)(=O)NC[C@H](C)Oc1ccccc1,1.3931999999999998
177794,Modify the molecule Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1 to increase its LogP value.,Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1,4.205160000000003
60349,Please modify the molecule O=C(COC(=O)Cc1ccccc1)Nc1ccc(F)cc1 to increase its LogP value.,O=C(COC(=O)Cc1ccccc1)Nc1ccc(F)cc1,2.5501000000000005
198819,Optimize the molecule Cc1ccc2c(c1)C1(OCCO1)C(=O)N2CCCOc1ccc2ccccc2c1 to have a higher LogP value.,Cc1ccc2c(c1)C1(OCCO1)C(=O)N2CCCOc1ccc2ccccc2c1,4.163520000000004
149990,Modify the molecule Cc1ccc(CN2CCN(c3cc(C4CC[NH2+]CC4)nc(C)n3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(CN2CCN(c3cc(C4CC[NH2+]CC4)nc(C)n3)CC2=O)cc1,1.38304
23357,Please modify the molecule O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1 to decrease its LogP value.,O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1,4.251300000000002
9004,Optimize the molecule CCOC(=O)C1=C(C)N=C2C[C@@H](C)[C@H](C(=O)OC)C(=O)[C@@H]2[C@H]1c1ccc(C)cc1 to have a higher LogP value.,CCOC(=O)C1=C(C)N=C2C[C@@H](C)[C@H](C(=O)OC)C(=O)[C@@H]2[C@H]1c1ccc(C)cc1,3.3846200000000026
135288,Modify the molecule Cc1[nH+]cn(C[C@H](C)NCc2nc(C(F)(F)F)cs2)c1C to have a lower LogP value.,Cc1[nH+]cn(C[C@H](C)NCc2nc(C(F)(F)F)cs2)c1C,2.5726400000000007
206668,Modify the molecule COC(=O)c1ccc(CNC(=O)NC[C@H]2COc3ccccc3O2)cc1 to decrease its LogP value.,COC(=O)c1ccc(CNC(=O)NC[C@H]2COc3ccccc3O2)cc1,2.112399999999999
31358,Modify the molecule COc1ccc(/C=N/c2cccc([N+](=O)[O-])c2C)c2ccccc12 to increase its LogP value.,COc1ccc(/C=N/c2cccc([N+](=O)[O-])c2C)c2ccccc12,4.8156200000000045
101918,Please optimize the molecule O=S(=O)(c1ccccc1)n1ccc2ccc(Br)nc21 to have a lower LogP value.,O=S(=O)(c1ccccc1)n1ccc2ccc(Br)nc21,3.035800000000002
102922,Please modify the molecule CC(C)(C(=O)N1CCn2c(nnc2C(F)(F)F)C1)c1cccc(C#N)c1 to increase its LogP value.,CC(C)(C(=O)N1CCn2c(nnc2C(F)(F)F)C1)c1cccc(C#N)c1,2.4885800000000007
140428,Modify the molecule CSCC[NH+](C)[C@@H](C)C(=O)Nc1c(C)cccc1C to have a higher LogP value.,CSCC[NH+](C)[C@@H](C)C(=O)Nc1c(C)cccc1C,1.5081399999999998
153812,Please modify the molecule Cc1ccc(Nc2cnn(C)c2)cc1N to increase its LogP value.,Cc1ccc(Nc2cnn(C)c2)cc1N,2.0543199999999997
3775,Modify the molecule CCN(CC)c1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SC)=NC(=O)[C@@H]32)cc1 to have a higher LogP value.,CCN(CC)c1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SC)=NC(=O)[C@@H]32)cc1,3.143200000000002
189246,Modify the molecule C[C@H]1CCC[C@H](C)N(C(=O)c2ccc(S(N)(=O)=O)c(F)c2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](C)N(C(=O)c2ccc(S(N)(=O)=O)c(F)c2)C1,2.1238
226847,Optimize the molecule CCOc1cc(C[NH+]2CCC[C@@H](COC)C2)cc(Cl)c1OC to have a lower LogP value.,CCOc1cc(C[NH+]2CCC[C@@H](COC)C2)cc(Cl)c1OC,2.1886
169316,Modify the molecule Clc1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)o1 to decrease its LogP value.,Clc1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)o1,1.2496999999999994
155889,Optimize the molecule N[C@@H](c1cccc(F)c1F)[C@H]1CSCCO1 to have a higher LogP value.,N[C@@H](c1cccc(F)c1F)[C@H]1CSCCO1,2.0966
192610,Optimize the molecule CC[C@@H](C[NH3+])C(=O)N1CCO[C@H](C#N)C1 to have a lower LogP value.,CC[C@@H](C[NH3+])C(=O)N1CCO[C@H](C#N)C1,-0.9945199999999985
228536,Optimize the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cn(CC)c3ccc(F)cc3c2=O)cc1 to have a lower LogP value.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cn(CC)c3ccc(F)cc3c2=O)cc1,3.4433000000000025
15985,Please modify the molecule C[C@H]1CCc2c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)csc2C1 to decrease its LogP value.,C[C@H]1CCc2c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)csc2C1,2.4503000000000004
32981,Please modify the molecule O=c1/c(=C/c2cccc([N+](=O)[O-])c2)sc2nc(/C=C/c3ccc(F)cc3)nn12 to decrease its LogP value.,O=c1/c(=C/c2cccc([N+](=O)[O-])c2)sc2nc(/C=C/c3ccc(F)cc3)nn12,2.916400000000001
123071,Optimize the molecule CC(=O)N[C@@H](CC(=O)Nc1cccc(C2=NN=CC2)c1)c1cccs1 to have a lower LogP value.,CC(=O)N[C@@H](CC(=O)Nc1cccc(C2=NN=CC2)c1)c1cccs1,3.1327000000000016
206808,Please optimize the molecule COC(=O)c1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)OC)c1 to have a lower LogP value.,COC(=O)c1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)OC)c1,2.5047000000000006
139641,Modify the molecule Cc1cc(F)ccc1CCNC(=O)c1ccc(CS(C)(=O)=O)cc1 to increase its LogP value.,Cc1cc(F)ccc1CCNC(=O)c1ccc(CS(C)(=O)=O)cc1,2.6512200000000012
72678,Modify the molecule C[C@@H](C#N)Oc1ccc(/C=C(/C#N)c2nc(-c3ccncc3)cs2)cc1 to decrease its LogP value.,C[C@@H](C#N)Oc1ccc(/C=C(/C#N)c2nc(-c3ccncc3)cs2)cc1,4.560160000000002
78050,Modify the molecule Cn1ncnc1C[NH+](C)CC(=O)NCc1ccc2c(c1)OCO2 to increase its LogP value.,Cn1ncnc1C[NH+](C)CC(=O)NCc1ccc2c(c1)OCO2,-1.1250999999999978
134523,Please modify the molecule O=S(=O)(NCCc1csc(-n2cccn2)n1)c1cc(F)cc(F)c1 to decrease its LogP value.,O=S(=O)(NCCc1csc(-n2cccn2)n1)c1cc(F)cc(F)c1,2.128
127576,Optimize the molecule Cc1cc(C(=O)Nc2cccc(NS(N)(=O)=O)c2)ccc1F to have a lower LogP value.,Cc1cc(C(=O)Nc2cccc(NS(N)(=O)=O)c2)ccc1F,2.0018200000000004
130307,Modify the molecule COCCNC(=O)c1cc2cc(OC)ccc2oc1=O to have a higher LogP value.,COCCNC(=O)c1cc2cc(OC)ccc2oc1=O,1.1778
14572,Modify the molecule CCc1nnc(NC(=O)c2cccc(C)c2C)s1 to have a lower LogP value.,CCc1nnc(NC(=O)c2cccc(C)c2C)s1,2.969640000000001
21886,Please optimize the molecule CC1=C[C@@H](C(=O)N(C)C[C@@H]2CCC[NH+](CCc3ccc(Cl)cc3)C2)N=N1 to have a higher LogP value.,CC1=C[C@@H](C(=O)N(C)C[C@@H]2CCC[NH+](CCc3ccc(Cl)cc3)C2)N=N1,2.3740000000000006
144895,Modify the molecule CCN(C[C@@H]1CCOC1)C(=O)c1nnn(-c2ccccc2Cl)c1C to decrease its LogP value.,CCN(C[C@@H]1CCOC1)C(=O)c1nnn(-c2ccccc2Cl)c1C,2.7277200000000006
32361,Modify the molecule Cc1c(Cl)ccc2sc(N3CCN(C(=O)c4cc(Cl)ccc4[N+](=O)[O-])CC3)nc12 to decrease its LogP value.,Cc1c(Cl)ccc2sc(N3CCN(C(=O)c4cc(Cl)ccc4[N+](=O)[O-])CC3)nc12,4.782120000000003
26292,Modify the molecule C[C@@H](C(=O)Nc1ccccc1Cl)n1cc(Br)cn1 to increase its LogP value.,C[C@@H](C(=O)Nc1ccccc1Cl)n1cc(Br)cn1,3.4987000000000013
216244,Please modify the molecule Cc1cccc(Nc2nc(CC(=O)Nc3cccnc3)cs2)n1 to increase its LogP value.,Cc1cccc(Nc2nc(CC(=O)Nc3cccnc3)cs2)n1,3.1663200000000007
150743,Modify the molecule CC(C)NC(=O)CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1 to increase its LogP value.,CC(C)NC(=O)CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1,1.4503
83898,Please modify the molecule Cc1cccc(CN2CCN(C(=O)CCC(=O)N(C)C)CC2)c1 to increase its LogP value.,Cc1cccc(CN2CCN(C(=O)CCC(=O)N(C)C)CC2)c1,1.5076199999999997
193566,Please optimize the molecule CC[C@@H](c1ccccc1)c1nnc(NC(=O)Nc2ccccc2F)s1 to have a higher LogP value.,CC[C@@H](c1ccccc1)c1nnc(NC(=O)Nc2ccccc2F)s1,4.863100000000002
180938,Modify the molecule CC1(C)CN(C(=O)CCc2nc(-c3ccco3)no2)CCO1 to have a lower LogP value.,CC1(C)CN(C(=O)CCc2nc(-c3ccco3)no2)CCO1,1.8996000000000002
243102,Please modify the molecule C[C@H]1CN(C(=O)[C@@H]2C[C@@H]2c2cccnc2)C[C@@H]1N1CCOCC1 to increase its LogP value.,C[C@H]1CN(C(=O)[C@@H]2C[C@@H]2c2cccnc2)C[C@@H]1N1CCOCC1,1.3641999999999999
247058,Optimize the molecule Cc1nn(C)c(C)c1NC(=O)[C@@H](C)Sc1nnc(NCc2ccco2)s1 to have a higher LogP value.,Cc1nn(C)c(C)c1NC(=O)[C@@H](C)Sc1nnc(NCc2ccco2)s1,3.212840000000001
246917,Please optimize the molecule CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1,2.649700000000001
175322,Modify the molecule CC(C)n1ncc2cc(NC(=O)CN3C(=O)[C@@H](C)Oc4ccccc43)cnc21 to have a higher LogP value.,CC(C)n1ncc2cc(NC(=O)CN3C(=O)[C@@H](C)Oc4ccccc43)cnc21,2.764800000000001
114191,Modify the molecule CCO[C@H]1C[C@H]([O-])C12CC[NH+]([C@@H]1CC[C@H](C)C1)CC2 to have a higher LogP value.,CCO[C@H]1C[C@H]([O-])C12CC[NH+]([C@@H]1CC[C@H](C)C1)CC2,0.3778000000000019
9792,Please modify the molecule CCCC(=O)N1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C)cc2)CC1 to increase its LogP value.,CCCC(=O)N1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C)cc2)CC1,1.2287200000000007
68384,Modify the molecule Cc1n[nH]c(C)c1NC(=O)Nc1ccc(F)cc1C(F)(F)F to increase its LogP value.,Cc1n[nH]c(C)c1NC(=O)Nc1ccc(F)cc1C(F)(F)F,3.8284400000000014
126860,Modify the molecule CCCOc1cc(C)ccc1NC(=O)N[C@@H]1CCC[C@@H](S(C)(=O)=O)C1 to decrease its LogP value.,CCCOc1cc(C)ccc1NC(=O)N[C@@H]1CCC[C@@H](S(C)(=O)=O)C1,3.261120000000002
47060,Modify the molecule OC[C@]1(Cc2ccccc2)CCC[NH+](Cc2cc(Cl)ccc2O)C1 to increase its LogP value.,OC[C@]1(Cc2ccccc2)CCC[NH+](Cc2cc(Cl)ccc2O)C1,2.4457000000000004
145504,Optimize the molecule CCN[C@]1(C#N)CC[C@@H]([NH+]2CCC[C@H](OCC)C2)C1 to have a lower LogP value.,CCN[C@]1(C#N)CC[C@@H]([NH+]2CCC[C@H](OCC)C2)C1,0.49458000000000113
13764,Optimize the molecule Cc1cc(OCC(=O)N(Cc2ccc(C(C)C)cc2)[C@@H]2CCS(=O)(=O)C2)ccc1Cl to have a lower LogP value.,Cc1cc(OCC(=O)N(Cc2ccc(C(C)C)cc2)[C@@H]2CCS(=O)(=O)C2)ccc1Cl,4.366520000000004
249338,Modify the molecule CC[C@H](C)CN(C)C(=O)NCc1cccc(NC(C)=O)c1 to have a higher LogP value.,CC[C@H](C)CN(C)C(=O)NCc1cccc(NC(C)=O)c1,2.8325000000000014
8974,Modify the molecule O=C(Cn1cnc2ccc([N+](=O)[O-])cc2c1=O)N1CCN(c2ccc(F)cc2)CC1 to have a higher LogP value.,O=C(Cn1cnc2ccc([N+](=O)[O-])cc2c1=O)N1CCN(c2ccc(F)cc2)CC1,1.7926000000000002
246606,Modify the molecule CC1=C(C#N)c2nc(N)c(C#N)c(C)c2/C1=C/c1ccc(-c2ccc(C(=O)[O-])cc2)o1 to have a higher LogP value.,CC1=C(C#N)c2nc(N)c(C#N)c(C)c2/C1=C/c1ccc(-c2ccc(C(=O)[O-])cc2)o1,3.3186800000000023
229566,Modify the molecule CC[NH+](CC)Cc1ccccc1CNC(=O)N1CCOCC1 to decrease its LogP value.,CC[NH+](CC)Cc1ccccc1CNC(=O)N1CCOCC1,0.6531000000000002
37782,Modify the molecule COc1ccccc1N1CCN(C(=O)c2ccc(O)c(C)c2)CC1=O to decrease its LogP value.,COc1ccccc1N1CCN(C(=O)c2ccc(O)c(C)c2)CC1=O,2.19822
114513,Modify the molecule Cc1cc(CN2CCCN(c3ncccn3)CC2)c(C)n1C1CC1 to have a higher LogP value.,Cc1cc(CN2CCCN(c3ncccn3)CC2)c(C)n1C1CC1,2.942140000000001
50734,Modify the molecule COc1ccc(/C=C2\Oc3cc(OC(=O)[C@H]4CCCO4)ccc3C2=O)c(OC)c1OC to decrease its LogP value.,COc1ccc(/C=C2\Oc3cc(OC(=O)[C@H]4CCCO4)ccc3C2=O)c(OC)c1OC,3.413000000000002
217237,Modify the molecule CC[C@@H]1CCCCN1C(=O)CSc1nnc(-c2cccs2)n1-c1ccccc1OC to have a lower LogP value.,CC[C@@H]1CCCCN1C(=O)CSc1nnc(-c2cccs2)n1-c1ccccc1OC,4.887600000000004
67628,Please modify the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c1 to increase its LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c1,4.853200000000003
219350,Please optimize the molecule Cc1nc(CNC(=O)Nc2ccc(OC(C)C)c(C)c2)c(C)s1 to have a higher LogP value.,Cc1nc(CNC(=O)Nc2ccc(OC(C)C)c(C)c2)c(C)s1,4.177260000000003
49936,Modify the molecule CC[C@](C)(CCN(C(C)=O)[C@H]1CCOC(C)(C)C1)c1ccccc1 to increase its LogP value.,CC[C@](C)(CCN(C(C)=O)[C@H]1CCOC(C)(C)C1)c1ccccc1,4.550500000000004
117742,Modify the molecule CCCN(CC(=O)N1CCc2sccc2[C@@H]1c1ccccc1)C(=O)C1CCCC1 to have a lower LogP value.,CCCN(CC(=O)N1CCc2sccc2[C@@H]1c1ccccc1)C(=O)C1CCCC1,4.651000000000004
68420,Modify the molecule CCc1cc(CNC(=O)c2cccc3[nH]ccc23)on1 to increase its LogP value.,CCc1cc(CNC(=O)c2cccc3[nH]ccc23)on1,2.6483
67134,Optimize the molecule CC(C)(CNC(=O)[C@H]1CCCN1C(=O)OCC(F)(F)F)c1ccncc1 to have a higher LogP value.,CC(C)(CNC(=O)[C@H]1CCCN1C(=O)OCC(F)(F)F)c1ccncc1,2.6387
132132,Modify the molecule CCCC(=O)OC[C@H](O)CN1CCOCC1 to have a higher LogP value.,CCCC(=O)OC[C@H](O)CN1CCOCC1,0.02279999999999993
118376,Modify the molecule O=C(c1csc(Nc2ccc(OC(F)F)cc2)n1)N1CCCC1 to have a higher LogP value.,O=C(c1csc(Nc2ccc(OC(F)F)cc2)n1)N1CCCC1,3.7241000000000026
160067,Optimize the molecule COC(=O)[C@@H](C)[C@@H](NC(=O)Cc1c[nH]c2cc(F)ccc12)c1ccccc1 to have a higher LogP value.,COC(=O)[C@@H](C)[C@@H](NC(=O)Cc1c[nH]c2cc(F)ccc12)c1ccccc1,3.5161000000000016
128724,Please optimize the molecule COc1ccc(-c2n[nH]cc2C[NH2+]C2CC2)cc1 to have a lower LogP value.,COc1ccc(-c2n[nH]cc2C[NH2+]C2CC2)cc1,1.3110999999999997
181990,Optimize the molecule COCCN1C(=O)C([O-])=C(C(=O)c2cc(C)ccc2C)[C@@H]1c1cccc(OC)c1 to have a lower LogP value.,COCCN1C(=O)C([O-])=C(C(=O)c2cc(C)ccc2C)[C@@H]1c1cccc(OC)c1,2.33904
167692,Modify the molecule c1csc(-c2csc(C[NH2+]C[C@@H]3CCc4nncn4C3)c2)c1 to have a lower LogP value.,c1csc(-c2csc(C[NH2+]C[C@@H]3CCc4nncn4C3)c2)c1,2.394100000000001
203947,Modify the molecule COc1ccc(-c2nc3c4cnn(-c5ccc(C)cc5C)c4ncn3n2)c(O)c1 to increase its LogP value.,COc1ccc(-c2nc3c4cnn(-c5ccc(C)cc5C)c4ncn3n2)c(O)c1,3.461240000000001
199191,Optimize the molecule Cc1csc(CCNc2ncnc3sc4c(c23)CC[C@@H](C)C4)n1 to have a lower LogP value.,Cc1csc(CCNc2ncnc3sc4c(c23)CC[C@@H](C)C4)n1,4.2356200000000035
94378,Modify the molecule COc1ccc([C@H](CNC(=O)c2ccccc2S(C)(=O)=O)[NH+](C)C)cc1 to have a higher LogP value.,COc1ccc([C@H](CNC(=O)c2ccccc2S(C)(=O)=O)[NH+](C)C)cc1,0.7143000000000008
117391,Modify the molecule COc1ccc2[nH]c(C)c(CCNC(=C3C(=O)N(C)C(=O)N(C)C3=O)c3ccc(Cl)cc3)c2c1 to have a higher LogP value.,COc1ccc2[nH]c(C)c(CCNC(=C3C(=O)N(C)C(=O)N(C)C3=O)c3ccc(Cl)cc3)c2c1,3.732120000000002
149484,Modify the molecule CNC(=O)CC1CCN(C(=O)NC[C@H](C)Cc2cccs2)CC1 to increase its LogP value.,CNC(=O)CC1CCN(C(=O)NC[C@H](C)Cc2cccs2)CC1,2.4844
133390,Please optimize the molecule O=C(OCc1ccccn1)c1cn(-c2cccc(F)c2)c(=O)c2ccccc12 to have a lower LogP value.,O=C(OCc1ccccn1)c1cn(-c2cccc(F)c2)c(=O)c2ccccc12,3.881800000000003
207554,Modify the molecule C[C@H]1OCC[C@H]1C(=O)N(Cc1ccccc1F)c1ccc(F)cc1 to increase its LogP value.,C[C@H]1OCC[C@H]1C(=O)N(Cc1ccccc1F)c1ccc(F)cc1,3.9230000000000027
52640,Please optimize the molecule Cc1ccccc1NC(=O)[C@@H](C)Sc1nnnn1Cc1ccccc1 to have a higher LogP value.,Cc1ccccc1NC(=O)[C@@H](C)Sc1nnnn1Cc1ccccc1,3.1491200000000017
239954,Please modify the molecule Oc1cccc(C[C@@H](O)c2ccc(OC(F)(F)F)cc2)c1 to decrease its LogP value.,Oc1cccc(C[C@@H](O)c2ccc(OC(F)(F)F)cc2)c1,3.5669000000000013
220691,Please optimize the molecule CCN(C(=O)c1ccc(SC)nc1)c1ccc(C)cc1C to have a lower LogP value.,CCN(C(=O)c1ccc(SC)nc1)c1ccc(C)cc1C,4.087040000000003
87015,Optimize the molecule CCC(=O)Nc1ccccc1-c1nc2ccccc2n([C@@H](C)C(=O)Nc2cccc(C#N)c2)c1=O to have a higher LogP value.,CCC(=O)Nc1ccccc1-c1nc2ccccc2n([C@@H](C)C(=O)Nc2cccc(C#N)c2)c1=O,4.483380000000002
68289,Modify the molecule Clc1ccc(CC[NH2+]C(C2CC2)C2CC2)cc1 to have a lower LogP value.,Clc1ccc(CC[NH2+]C(C2CC2)C2CC2)cc1,2.634500000000001
167501,Please optimize the molecule Cc1cccc([C@@H](CCC[C@@H]2CCCO2)C(=O)[O-])c1 to have a higher LogP value.,Cc1cccc([C@@H](CCC[C@@H]2CCCO2)C(=O)[O-])c1,2.1778199999999996
35805,Please optimize the molecule COc1ccc(C(=O)NCC(=O)N/N=C/c2ccc([N+](=O)[O-])s2)cc1 to have a lower LogP value.,COc1ccc(C(=O)NCC(=O)N/N=C/c2ccc([N+](=O)[O-])s2)cc1,1.545
25977,Please optimize the molecule O=C(COc1cccc(Cl)c1)Nc1ccccc1[N+](=O)[O-] to have a higher LogP value.,O=C(COc1cccc(Cl)c1)Nc1ccccc1[N+](=O)[O-],3.2657000000000007
122701,Modify the molecule O=C(Cc1cccs1)N1CCc2nocc2C1 to have a lower LogP value.,O=C(Cc1cccs1)N1CCc2nocc2C1,1.8635
213186,Modify the molecule Cc1ccc(C(=O)NC[C@H](C)Cn2nc(C)cc2C)cn1 to have a lower LogP value.,Cc1ccc(C(=O)NC[C@H](C)Cn2nc(C)cc2C)cn1,2.2694600000000005
111867,Modify the molecule O=C(C[NH+]1CCC[C@H](C(=O)NCC(F)(F)F)C1)Nc1cccnc1 to have a lower LogP value.,O=C(C[NH+]1CCC[C@H](C(=O)NCC(F)(F)F)C1)Nc1cccnc1,-0.006500000000000117
27450,Optimize the molecule CN[C@@H](c1ccccc1C)C1([NH+]2CCCC2)CCCC1 to have a higher LogP value.,CN[C@@H](c1ccccc1C)C1([NH+]2CCCC2)CCCC1,2.24702
169059,Modify the molecule c1cc2c(cc1Cc1nn3c(CN4CCOCC4)nnc3s1)CCCC2 to decrease its LogP value.,c1cc2c(cc1Cc1nn3c(CN4CCOCC4)nnc3s1)CCCC2,2.4876000000000005
203892,Please modify the molecule CCCn1c(-c2cccc(C)c2)nnc1S(C)(=O)=O to decrease its LogP value.,CCCn1c(-c2cccc(C)c2)nnc1S(C)(=O)=O,2.0670199999999994
221782,Optimize the molecule CC(=O)N(C)c1cccc(NC(=O)C[C@@H](O)c2ccccc2)c1 to have a lower LogP value.,CC(=O)N(C)c1cccc(NC(=O)C[C@@H](O)c2ccccc2)c1,2.7315000000000014
210958,Modify the molecule C[NH+](C)CCSc1nc(-c2ccccc2)c[nH]1 to have a lower LogP value.,C[NH+](C)CCSc1nc(-c2ccccc2)c[nH]1,1.3133000000000001
246858,Optimize the molecule COC(=O)c1sccc1NC(=O)c1ccc(O)cc1 to have a higher LogP value.,COC(=O)c1sccc1NC(=O)c1ccc(O)cc1,2.4926000000000004
175529,Please optimize the molecule CC(C)(Cc1cccc(Cl)c1)C(=O)NCc1cc(=O)[nH]c2ccccc12 to have a higher LogP value.,CC(C)(Cc1cccc(Cl)c1)C(=O)NCc1cc(=O)[nH]c2ccccc12,4.066600000000002
70164,Modify the molecule CCn1ncc(Br)c1C(=O)N1CCC[C@H](C)C1 to have a lower LogP value.,CCn1ncc(Br)c1C(=O)N1CCC[C@H](C)C1,2.537600000000001
172951,Modify the molecule O=C(/C=C/c1nc2ccccc2s1)Nc1ccc(Cl)cc1 to increase its LogP value.,O=C(/C=C/c1nc2ccccc2s1)Nc1ccc(Cl)cc1,4.601600000000002
98190,Modify the molecule O=C(Nc1ccc2c(c1)CCC2)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)s1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)CCC2)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)s1,3.682000000000003
61880,Modify the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)C(=O)NC[C@@H](c1cccn1C)[NH+]1CCOCC1 to decrease its LogP value.,Cc1ccc([N+](=O)[O-])cc1NC(=O)C(=O)NC[C@@H](c1cccn1C)[NH+]1CCOCC1,-0.04717999999999889
128691,Please modify the molecule CC(=O)c1ccc(NC(=O)NC[C@H]2CCC[C@@H]2O)cc1C to decrease its LogP value.,CC(=O)c1ccc(NC(=O)NC[C@H]2CCC[C@@H]2O)cc1C,2.4801200000000003
155130,Optimize the molecule CCOc1ccccc1/C=C(\NC(=O)c1ccccc1)C(=O)Nc1cccc(O)c1 to have a higher LogP value.,CCOc1ccccc1/C=C(\NC(=O)c1ccccc1)C(=O)Nc1cccc(O)c1,4.2005000000000035
20931,Please modify the molecule COc1cc(/C=N/NC(=O)[C@H](C)Oc2ccc3ccccc3c2)ccc1O to decrease its LogP value.,COc1cc(/C=N/NC(=O)[C@H](C)Oc2ccc3ccccc3c2)ccc1O,3.4716000000000027
142356,Modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)NCCc2sc(C)nc2C)C1 to increase its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)NCCc2sc(C)nc2C)C1,1.0256399999999997
204345,Optimize the molecule Cc1cccc(C(=O)Nc2ccnc(-c3ccccc3)n2)c1F to have a higher LogP value.,Cc1cccc(C(=O)Nc2ccnc(-c3ccccc3)n2)c1F,3.843420000000002
172876,Please modify the molecule CCCn1ccnc1-c1nc(Cl)ncc1F to increase its LogP value.,CCCn1ccnc1-c1nc(Cl)ncc1F,2.5426
191960,Please optimize the molecule O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(C(=O)c2ccco2)CC1 to have a higher LogP value.,O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(C(=O)c2ccco2)CC1,4.0618000000000025
146353,Please optimize the molecule C[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccccc1 to have a lower LogP value.,C[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccccc1,3.6692000000000027
142429,Please modify the molecule O=C(Nc1ccc(N2C(=O)CCCC2=O)cc1)[C@@H]1CCOc2ccccc21 to increase its LogP value.,O=C(Nc1ccc(N2C(=O)CCCC2=O)cc1)[C@@H]1CCOc2ccccc21,3.2349000000000023
74502,Optimize the molecule CCCn1nc(C(=O)N2CCSCC2)c2c1CC[C@@H]([NH+](C)CCOC)C2 to have a lower LogP value.,CCCn1nc(C(=O)N2CCSCC2)c2c1CC[C@@H]([NH+](C)CCOC)C2,0.5005000000000026
15476,Modify the molecule C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1cncc2ccccc12 to decrease its LogP value.,C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1cncc2ccccc12,2.6755000000000004
18095,Modify the molecule ClCc1cncc(Oc2ccc(Cl)c3ccccc23)n1 to have a lower LogP value.,ClCc1cncc(Oc2ccc(Cl)c3ccccc23)n1,4.814300000000003
43969,Please modify the molecule CC1(C)CC(=O)C2=C(C1)NC1=NC(SCc3ccccc3)=NC(=O)[C@@H]1[C@H]2c1ccncc1 to increase its LogP value.,CC1(C)CC(=O)C2=C(C1)NC1=NC(SCc3ccccc3)=NC(=O)[C@@H]1[C@H]2c1ccncc1,4.255900000000003
41758,Modify the molecule C[C@H](NC(=O)C[NH+]1CC[C@H](C)[C@@H](O)C1)c1ccc2ccccc2c1 to increase its LogP value.,C[C@H](NC(=O)C[NH+]1CC[C@H](C)[C@@H](O)C1)c1ccc2ccccc2c1,1.302600000000001
102340,Optimize the molecule O=c1[nH]c2ccccc2nc1CN1CCOCC1 to have a lower LogP value.,O=c1[nH]c2ccccc2nc1CN1CCOCC1,0.7552999999999999
231663,Please modify the molecule CC(C)C[C@@H]1NC(=O)N(CCN2CCOCC2)C1=O to increase its LogP value.,CC(C)C[C@@H]1NC(=O)N(CCN2CCOCC2)C1=O,0.2851000000000006
65995,Modify the molecule CNC(=O)[C@H]1Cc2ccccc2C[NH+]1Cc1nc(-c2ccccc2)no1 to have a higher LogP value.,CNC(=O)[C@H]1Cc2ccccc2C[NH+]1Cc1nc(-c2ccccc2)no1,0.9923999999999997
209697,Please optimize the molecule CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O to have a lower LogP value.,CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O,3.384800000000002
173098,Optimize the molecule COCCN1C[C@@H](C(=O)NC2CCC(C)CC2)CC1=O to have a lower LogP value.,COCCN1C[C@@H](C(=O)NC2CCC(C)CC2)CC1=O,1.1762
113718,Please modify the molecule Cc1nnc(-c2ccc(C(=O)N(C)[C@@H](C)CNC(=O)OC(C)(C)C)cc2)o1 to decrease its LogP value.,Cc1nnc(-c2ccc(C(=O)N(C)[C@@H](C)CNC(=O)OC(C)(C)C)cc2)o1,3.0302200000000017
142799,Please modify the molecule COc1ccc(CNC(=O)c2cc(S(=O)(=O)NC(C)(C)C)ccc2C)cc1 to decrease its LogP value.,COc1ccc(CNC(=O)c2cc(S(=O)(=O)NC(C)(C)C)ccc2C)cc1,3.0104200000000017
218895,Please optimize the molecule CCOc1cc([N+](=O)[O-])c(C(=O)N2CCCc3cccc(C)c32)cc1OC to have a lower LogP value.,CCOc1cc([N+](=O)[O-])c(C(=O)N2CCCc3cccc(C)c32)cc1OC,3.903520000000003
248116,Please modify the molecule OC[C@H]1CC[NH+](Cc2cccc(OCc3ccccc3F)c2)C1 to decrease its LogP value.,OC[C@H]1CC[NH+](Cc2cccc(OCc3ccccc3F)c2)C1,1.8017999999999994
162756,Please optimize the molecule CC(C)c1cc(N2C[C@H](C(N)=O)CC[C@H]2C)nc(C(C)C)[nH+]1 to have a lower LogP value.,CC(C)c1cc(N2C[C@H](C(N)=O)CC[C@H]2C)nc(C(C)C)[nH+]1,2.2327
177038,Optimize the molecule CC1CC[NH+]([C@H](C)CNC(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1 to have a higher LogP value.,CC1CC[NH+]([C@H](C)CNC(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1,2.3169000000000004
177422,Please optimize the molecule COCC(=O)N1CCC[C@@H]1c1cccc(Cc2ccccc2)n1 to have a lower LogP value.,COCC(=O)N1CCC[C@@H]1c1cccc(Cc2ccccc2)n1,2.9823000000000013
29811,Please optimize the molecule Cc1cccc([C@@H](C)NC(=O)c2cn(CC(N)=O)nn2)c1C to have a higher LogP value.,Cc1cccc([C@@H](C)NC(=O)c2cn(CC(N)=O)nn2)c1C,0.87124
140680,Please modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H](C)c2ccc(OC)cc2)C1 to decrease its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H](C)c2ccc(OC)cc2)C1,1.3388999999999993
55385,Modify the molecule CCCCOC(=O)Cc1c(C)[nH]c(=O)[nH]c1=O to have a lower LogP value.,CCCCOC(=O)Cc1c(C)[nH]c(=O)[nH]c1=O,0.2574200000000001
135160,Please optimize the molecule CCN(C(=O)Nc1cccnc1Cl)[C@@H](C)C(C)C to have a higher LogP value.,CCN(C(=O)Nc1cccnc1Cl)[C@@H](C)C(C)C,3.633300000000003
162358,Optimize the molecule CC(C)C[C@@H](C)OCc1nc2ccc(N)cc2o1 to have a higher LogP value.,CC(C)C[C@@H](C)OCc1nc2ccc(N)cc2o1,3.361200000000001
244846,Please modify the molecule C[NH2+][C@@H](c1cc(C)ccc1F)[C@H]1CN2CCC[C@@H]2CO1 to increase its LogP value.,C[NH2+][C@@H](c1cc(C)ccc1F)[C@H]1CN2CCC[C@@H]2CO1,1.2316199999999997
214807,Modify the molecule COc1ccc(OC)c(S(=O)(=O)Nc2ccc(Oc3ccccc3)nc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)Nc2ccc(Oc3ccccc3)nc2)c1,3.691900000000002
143643,Modify the molecule C[NH+]1CCCC[C@H]1CN1CCN(Cc2cnc(C3CCC3)s2)CC1 to decrease its LogP value.,C[NH+]1CCCC[C@H]1CN1CCN(Cc2cnc(C3CCC3)s2)CC1,1.5954000000000004
38815,Please optimize the molecule CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C to have a lower LogP value.,CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C,3.0148400000000013
176698,Please modify the molecule CC(C)CC[C@@]1(CC(=O)[O-])CCOC(C)(C)C1 to decrease its LogP value.,CC(C)CC[C@@]1(CC(=O)[O-])CCOC(C)(C)C1,2.138
98582,Please optimize the molecule Cn1cc([C@H]2CN(C(=O)c3sccc3C#N)CCO2)cn1 to have a higher LogP value.,Cn1cc([C@H]2CN(C(=O)c3sccc3C#N)CCO2)cn1,1.56698
32230,Optimize the molecule Cc1c(C(=O)OCc2nc3ccccc3o2)cnn1C(C)C to have a higher LogP value.,Cc1c(C(=O)OCc2nc3ccccc3o2)cnn1C(C)C,3.270620000000002
222899,Modify the molecule Cc1ccc(-c2nnc(SCC(=O)Nc3ccccc3I)n2N)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(SCC(=O)Nc3ccccc3I)n2N)cc1,3.3027200000000008
232539,Optimize the molecule OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1 to have a higher LogP value.,OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1,4.472000000000002
96165,Optimize the molecule C#CCn1/c(=N/S(=O)(=O)c2ccc(OC)cc2)sc2cccc(F)c21 to have a lower LogP value.,C#CCn1/c(=N/S(=O)(=O)c2ccc(OC)cc2)sc2cccc(F)c21,2.7733000000000008
107424,Optimize the molecule N#CC1=C(N)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)[C@H]1[C@@H]1C=NN=C1c1ccccc1 to have a higher LogP value.,N#CC1=C(N)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)[C@H]1[C@@H]1C=NN=C1c1ccccc1,4.947480000000003
243859,Modify the molecule CC[C@](C)(C(=O)NC1CCCC1)N(C[C@H]1CCCO1)C(=O)c1ccc(=O)[nH]c1 to have a higher LogP value.,CC[C@](C)(C(=O)NC1CCCC1)N(C[C@H]1CCCO1)C(=O)c1ccc(=O)[nH]c1,2.2235999999999994
164808,Please modify the molecule CCCCc1c([O-])nc(-c2ccccc2Br)oc1=O to increase its LogP value.,CCCCc1c([O-])nc(-c2ccccc2Br)oc1=O,2.8805000000000014
107492,Please optimize the molecule Cc1nn(C)c(C)c1CCC(=O)N1CCC[C@H]1c1nc(-c2ccccc2)no1 to have a higher LogP value.,Cc1nn(C)c(C)c1CCC(=O)N1CCC[C@H]1c1nc(-c2ccccc2)no1,3.3832400000000025
97423,Please optimize the molecule Cc1ccc([C@@H](C)NC(=O)N2CCC[C@@H](CNC(=O)C(C)(C)C)C2)cc1F to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)N2CCC[C@@H](CNC(=O)C(C)(C)C)C2)cc1F,3.7790200000000027
43073,Optimize the molecule C[C@H](N[C@H](C)c1nccs1)c1cc(F)ccc1N1CCC(O)CC1 to have a lower LogP value.,C[C@H](N[C@H](C)c1nccs1)c1cc(F)ccc1N1CCC(O)CC1,3.6551000000000027
100264,Modify the molecule O=C(CCCN1C(=O)c2ccccc2N[C@@H]1O)NC1=CC2=CC=N[C@@H]2C=C1 to have a lower LogP value.,O=C(CCCN1C(=O)c2ccccc2N[C@@H]1O)NC1=CC2=CC=N[C@@H]2C=C1,1.5596999999999999
196211,Modify the molecule O=C(NCc1ccc(F)cc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(Cl)cc1 to decrease its LogP value.,O=C(NCc1ccc(F)cc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(Cl)cc1,3.201900000000002
122525,Modify the molecule CC(=O)Nc1cc(N[C@H]2CC(=O)N(c3ccc4ccccc4c3)C2=O)ccc1C to have a lower LogP value.,CC(=O)Nc1cc(N[C@H]2CC(=O)N(c3ccc4ccccc4c3)C2=O)ccc1C,3.850620000000003
201330,Please optimize the molecule COc1cc(C)c(C(=O)N[C@@H]2CCCC2(C)C)cc1OC to have a lower LogP value.,COc1cc(C)c(C(=O)N[C@@H]2CCCC2(C)C)cc1OC,3.3207200000000023
70012,Modify the molecule Cc1ccc(NCCNc2ccc(C)cc2C)cc1 to increase its LogP value.,Cc1ccc(NCCNc2ccc(C)cc2C)cc1,4.135860000000003
73200,Please optimize the molecule O=C1c2ccccc2C(=O)N1N1C(=O)c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2C1=O to have a lower LogP value.,O=C1c2ccccc2C(=O)N1N1C(=O)c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2C1=O,3.194300000000002
14314,Optimize the molecule COc1ccccc1-n1ncc2c([O-])nc(-n3nc(C)cc3NC(=O)C3CCCC3)nc21 to have a lower LogP value.,COc1ccccc1-n1ncc2c([O-])nc(-n3nc(C)cc3NC(=O)C3CCCC3)nc21,2.5205200000000003
91401,Modify the molecule Cc1ccc(C)c(OCCSCc2cc(=O)n3ccccc3n2)c1 to have a higher LogP value.,Cc1ccc(C)c(OCCSCc2cc(=O)n3ccccc3n2)c1,3.623540000000002
39321,Please modify the molecule CCOC(=O)c1ccc(OS(=O)(=O)c2ccc3c(c2)OCCO3)cc1 to decrease its LogP value.,CCOC(=O)c1ccc(OS(=O)(=O)c2ccc3c(c2)OCCO3)cc1,2.4022000000000006
119051,Please modify the molecule Cc1c(C)c(C)c(S(=O)(=O)N(Cc2ccc(C(N)=O)cc2)C2CC2)c(C)c1C to decrease its LogP value.,Cc1c(C)c(C)c(S(=O)(=O)N(Cc2ccc(C(N)=O)cc2)C2CC2)c(C)c1C,3.680900000000003
27807,Please modify the molecule C[C@H]1C[C@H]1c1ccc(CN(C)C(=O)c2ccc(N3CCCC3=O)cc2)o1 to decrease its LogP value.,C[C@H]1C[C@H]1c1ccc(CN(C)C(=O)c2ccc(N3CCCC3=O)cc2)o1,3.802000000000003
244205,Please modify the molecule CC[NH2+]Cc1ccc(OCC(=O)NC2CCCC2)cn1 to decrease its LogP value.,CC[NH2+]Cc1ccc(OCC(=O)NC2CCCC2)cn1,0.6025
1292,Modify the molecule CCCCC(=O)N1CCN(c2nc3cccnc3s2)CC1 to have a lower LogP value.,CCCCC(=O)N1CCN(c2nc3cccnc3s2)CC1,2.530100000000001
203179,Modify the molecule CCOC(=O)c1cccc(NC(=O)NC[C@@H](O)c2ccc(F)cc2)c1 to increase its LogP value.,CCOC(=O)c1cccc(NC(=O)NC[C@@H](O)c2ccc(F)cc2)c1,2.8575000000000017
137980,Please modify the molecule Cc1nc(SCC(=O)c2cccc(Br)c2)oc1C to increase its LogP value.,Cc1nc(SCC(=O)c2cccc(Br)c2)oc1C,4.028940000000002
28492,Please optimize the molecule CCCCC(=O)N(C)CC(=O)Nc1cc(Cl)ccc1OC to have a lower LogP value.,CCCCC(=O)N(C)CC(=O)Nc1cc(Cl)ccc1OC,2.9357000000000006
235420,Please optimize the molecule CC(C)=CCC[C@@]1(C)CCC(=O)N(Cc2csc3[n+]2CCN3)C1 to have a lower LogP value.,CC(C)=CCC[C@@]1(C)CCC(=O)N(Cc2csc3[n+]2CCN3)C1,3.3362000000000016
221047,Optimize the molecule CN(CC(C)(C)O)C(=O)Cc1ccc(C(F)(F)F)cc1 to have a higher LogP value.,CN(CC(C)(C)O)C(=O)Cc1ccc(C(F)(F)F)cc1,2.4772000000000007
8015,Optimize the molecule O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)[C@@H]2C=C(c3ccncc3)N=N2)C1 to have a lower LogP value.,O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)[C@@H]2C=C(c3ccncc3)N=N2)C1,3.1342000000000017
64479,Optimize the molecule COc1ccc2c(c1)N(S(=O)(=O)CC1CCC1)CCO2 to have a lower LogP value.,COc1ccc2c(c1)N(S(=O)(=O)CC1CCC1)CCO2,2.0239
4123,Modify the molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S to have a higher LogP value.,C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S,0.6871100000000008
5752,Please optimize the molecule Cc1ccc(N2CC[NH2+][C@H](C)C2)c(C)n1 to have a lower LogP value.,Cc1ccc(N2CC[NH2+][C@H](C)C2)c(C)n1,0.47034
29694,Please modify the molecule OCC#Cc1ccsc1CN1CC[NH+]2CCCC[C@@H]2C1 to decrease its LogP value.,OCC#Cc1ccsc1CN1CC[NH+]2CCCC[C@@H]2C1,0.34490000000000043
58815,Modify the molecule CCOc1cc2c(cc1/C=C(\C#N)c1nc3ccccc3[nH]1)OCO2 to have a lower LogP value.,CCOc1cc2c(cc1/C=C(\C#N)c1nc3ccccc3[nH]1)OCO2,3.7544800000000036
28318,Modify the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@@H]1CCN(c2ccccc2F)C1=O to have a higher LogP value.,C[C@H](Cc1ccccc1F)C(=O)N[C@@H]1CCN(c2ccccc2F)C1=O,3.065100000000001
167098,Modify the molecule C[C@@H](NC(=O)CCC1CCCCC1)c1ccc(S(N)(=O)=O)cc1 to have a lower LogP value.,C[C@@H](NC(=O)CCC1CCCCC1)c1ccc(S(N)(=O)=O)cc1,2.8717000000000006
185242,Modify the molecule O=C(CNC(=O)c1ccc(-c2cscn2)cc1)Nc1ccc(F)cc1 to have a lower LogP value.,O=C(CNC(=O)c1ccc(-c2cscn2)cc1)Nc1ccc(F)cc1,3.317700000000001
106099,Modify the molecule COc1ncncc1NC(=O)N[C@@H](CC(F)(F)F)c1ccc(F)cc1 to increase its LogP value.,COc1ncncc1NC(=O)N[C@@H](CC(F)(F)F)c1ccc(F)cc1,3.4395000000000016
1408,Modify the molecule [NH3+]C[C@H]1CCC[C@H]1N1CCOCC1 to increase its LogP value.,[NH3+]C[C@H]1CCC[C@H]1N1CCOCC1,-0.27080000000000015
165333,Please optimize the molecule N#Cc1ccc(C(=O)Nc2cccnc2Cl)cc1 to have a higher LogP value.,N#Cc1ccc(C(=O)Nc2cccnc2Cl)cc1,2.8589800000000007
221571,Optimize the molecule O=C([O-])/C=C/C(=O)Nc1ccccn1 to have a higher LogP value.,O=C([O-])/C=C/C(=O)Nc1ccccn1,-0.6738000000000008
195104,Modify the molecule Cc1c(NS(=O)(=O)c2cccc3c2C(=O)c2ccccc2C3=O)c(=O)n(-c2ccccc2)n1C to have a lower LogP value.,Cc1c(NS(=O)(=O)c2cccc3c2C(=O)c2ccccc2C3=O)c(=O)n(-c2ccccc2)n1C,3.060620000000001
160886,Please modify the molecule Cc1cc(S(=O)(=O)N[C@H](C)CC(C)C)cc(N)c1C to decrease its LogP value.,Cc1cc(S(=O)(=O)N[C@H](C)CC(C)C)cc(N)c1C,2.5985400000000007
167975,Optimize the molecule COc1ccc(NC(=O)Nc2nnc(CCc3ccccc3)s2)cc1 to have a higher LogP value.,COc1ccc(NC(=O)Nc2nnc(CCc3ccccc3)s2)cc1,3.975900000000002
187637,Modify the molecule CC1(CNC(=O)Cc2ccc(S(=O)(=O)C(F)F)cc2)CCCC1 to have a lower LogP value.,CC1(CNC(=O)Cc2ccc(S(=O)(=O)C(F)F)cc2)CCCC1,2.9219000000000017
149974,Please modify the molecule C/C(=N\NC(=O)c1cc(-c2ccc(F)cc2)[nH]n1)c1cccc2ccccc12 to increase its LogP value.,C/C(=N\NC(=O)c1cc(-c2ccc(F)cc2)[nH]n1)c1cccc2ccccc12,4.523000000000002
241775,Modify the molecule O=C(COc1ccccc1)Nc1cccc(-c2cnc3ccccc3n2)c1 to have a higher LogP value.,O=C(COc1ccccc1)Nc1cccc(-c2cnc3ccccc3n2)c1,4.314300000000003
180795,Modify the molecule CC(C)C[C@H]1C[NH2+]CCC12Cc1ccccc1C2 to increase its LogP value.,CC(C)C[C@H]1C[NH2+]CCC12Cc1ccccc1C2,2.4010000000000007
111600,Modify the molecule Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)N1CCC1 to have a higher LogP value.,Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)N1CCC1,2.7391200000000016
117881,Modify the molecule CC[C@H](CCO)C[NH2+][C@@H](C)c1cc(C)sc1C to decrease its LogP value.,CC[C@H](CCO)C[NH2+][C@@H](C)c1cc(C)sc1C,2.39794
7576,Please optimize the molecule C[NH2+][C@@H](C)c1nc2ncc(C)cc2[n-]1 to have a lower LogP value.,C[NH2+][C@@H](C)c1nc2ncc(C)cc2[n-]1,0.14961999999999964
97676,Please modify the molecule Cc1ccc(CC(=O)N2CCN(CC(=O)N(C)CCC#N)CC2)cc1 to increase its LogP value.,Cc1ccc(CC(=O)N2CCN(CC(=O)N(C)CCC#N)CC2)cc1,1.0538000000000005
97245,Please optimize the molecule [O-]c1ncnc2c(Br)[nH]nc12 to have a higher LogP value.,[O-]c1ncnc2c(Br)[nH]nc12,0.189
114532,Please modify the molecule O=C(CCCn1cncn1)N[C@H]1CCc2[nH+]ccn2C1 to increase its LogP value.,O=C(CCCn1cncn1)N[C@H]1CCc2[nH+]ccn2C1,-0.19489999999999963
209955,Modify the molecule C[C@@H]1CCC[C@@H]([NH+]2CCC(N[C@@H](CO)c3cc(F)c(F)c(F)c3)CC2)C1 to have a higher LogP value.,C[C@@H]1CCC[C@@H]([NH+]2CCC(N[C@@H](CO)c3cc(F)c(F)c(F)c3)CC2)C1,2.3529
234183,Modify the molecule O=C([C@@H]1CCCCN1C(=O)c1cccc2[nH]ccc12)N1CCOCC1 to have a higher LogP value.,O=C([C@@H]1CCCCN1C(=O)c1cccc2[nH]ccc12)N1CCOCC1,2.0214
112582,Modify the molecule Cc1cc(NC(=O)C[C@@H]2Oc3ccccc3NC2=O)ccc1Br to have a lower LogP value.,Cc1cc(NC(=O)C[C@@H]2Oc3ccccc3NC2=O)ccc1Br,3.4858200000000013
174868,Modify the molecule C[C@H](CC(=O)[O-])Sc1ccc(F)cc1 to have a lower LogP value.,C[C@H](CC(=O)[O-])Sc1ccc(F)cc1,1.4463000000000001
71984,Modify the molecule O=C(Nc1nnc(-c2cc3ccccc3o2)o1)c1ccccc1Br to decrease its LogP value.,O=C(Nc1nnc(-c2cc3ccccc3o2)o1)c1ccccc1Br,4.497600000000001
183179,Optimize the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1[NH2+]Cc1ccc(F)cc1F to have a higher LogP value.,CC[S@@](=O)[C@H]1CCCC[C@@H]1[NH2+]Cc1ccc(F)cc1F,2.1079999999999997
156969,Modify the molecule O=C(c1nn(Cc2ccncc2)c2c1CN(C(=O)[C@@H](c1ccccc1)C1CCCC1)CC2)N1CCCC1 to decrease its LogP value.,O=C(c1nn(Cc2ccncc2)c2c1CN(C(=O)[C@@H](c1ccccc1)C1CCCC1)CC2)N1CCCC1,4.4211000000000045
238542,Please optimize the molecule C=CCN(CC=C)C(=O)c1cccc([N+](=O)[O-])c1 to have a higher LogP value.,C=CCN(CC=C)C(=O)c1cccc([N+](=O)[O-])c1,2.4090000000000007
50248,Modify the molecule O=[N+]([O-])c1ccc2nc(NC[C@H]3CCC[C@@H]3O)oc2c1 to have a lower LogP value.,O=[N+]([O-])c1ccc2nc(NC[C@H]3CCC[C@@H]3O)oc2c1,2.3089000000000004
58399,Please optimize the molecule Cc1ccc2c(c1)=[NH+]C(=O)[C@H](CN(C(=O)C1CCCCC1)C(C)(C)C)C=2 to have a higher LogP value.,Cc1ccc2c(c1)=[NH+]C(=O)[C@H](CN(C(=O)C1CCCCC1)C(C)(C)C)C=2,0.8395200000000012
112135,Modify the molecule Cc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccccn1 to have a lower LogP value.,Cc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccccn1,2.2151199999999998
64632,Modify the molecule COc1cc(NC2CCN(S(=O)(=O)C3CC3)CC2)ccc1[N+](=O)[O-] to have a lower LogP value.,COc1cc(NC2CCN(S(=O)(=O)C3CC3)CC2)ccc1[N+](=O)[O-],1.9718999999999995
240384,Modify the molecule CN(C)C(=O)c1cccc(C(=O)OC2CCN(CC(F)(F)F)CC2)c1 to have a lower LogP value.,CN(C)C(=O)c1cccc(C(=O)OC2CCN(CC(F)(F)F)CC2)c1,2.571900000000001
68205,Please modify the molecule Cc1ccccc1[C@@H](Nc1cncc(C(N)=O)n1)C(C)(C)C to decrease its LogP value.,Cc1ccccc1[C@@H](Nc1cncc(C(N)=O)n1)C(C)(C)C,3.0832200000000016
213140,Optimize the molecule Cc1noc(C)c1C[NH+]1CC[C@H](NC(=O)OC(C)(C)C)C1 to have a lower LogP value.,Cc1noc(C)c1C[NH+]1CC[C@H](NC(=O)OC(C)(C)C)C1,0.9733400000000001
46252,Please modify the molecule Cc1ccc2oc(SCCCS(C)(=O)=O)nc2c1 to increase its LogP value.,Cc1ccc2oc(SCCCS(C)(=O)=O)nc2c1,2.6630200000000004
199089,Please modify the molecule COC(=O)c1cc(Nc2cccnc2C)c(F)cc1N to decrease its LogP value.,COC(=O)c1cc(Nc2cccnc2C)c(F)cc1N,2.64152
203010,Please optimize the molecule Cc1cc(C[C@@H](C)[NH2+]C2CCN(c3ccc(Cl)cc3)CC2)n[nH]1 to have a lower LogP value.,Cc1cc(C[C@@H](C)[NH2+]C2CCN(c3ccc(Cl)cc3)CC2)n[nH]1,2.5349199999999996
189737,Modify the molecule C[S@@](=O)c1ccc(CNCC(C)(C)c2ccc(F)cc2)cc1 to have a higher LogP value.,C[S@@](=O)c1ccc(CNCC(C)(C)c2ccc(F)cc2)cc1,3.6305000000000023
164671,Modify the molecule Cc1ncc([C@@H](C)N[C@@H]2CCN(c3ccccc3Cl)C2=O)c(C)n1 to increase its LogP value.,Cc1ncc([C@@H](C)N[C@@H]2CCN(c3ccccc3Cl)C2=O)c(C)n1,3.2029400000000017
159284,Please optimize the molecule CC(C)[C@H](NC(=O)C=C1CCSCC1)c1nc(-c2ccncc2)no1 to have a higher LogP value.,CC(C)[C@H](NC(=O)C=C1CCSCC1)c1nc(-c2ccncc2)no1,3.3983000000000025
68542,Optimize the molecule COC(=O)[C@@](C)(NCC(=O)N[C@@H]1CCCC[C@H]1C)C1CC1 to have a lower LogP value.,COC(=O)[C@@](C)(NCC(=O)N[C@@H]1CCCC[C@H]1C)C1CC1,1.6125999999999991
178948,Please optimize the molecule Clc1cccc2c1OCC[C@@H]2NCc1cnc(-c2ccccn2)s1 to have a lower LogP value.,Clc1cccc2c1OCC[C@@H]2NCc1cnc(-c2ccccn2)s1,4.471900000000002
92524,Optimize the molecule Cc1ccc(NC(=O)C2CCN(C(=O)Nc3ccc(C)c(C)c3)CC2)nc1 to have a higher LogP value.,Cc1ccc(NC(=O)C2CCN(C(=O)Nc3ccc(C)c(C)c3)CC2)nc1,3.8894600000000024
186735,Modify the molecule C[C@@H](Oc1ccccc1C#N)C(=O)Oc1ccc(F)cc1 to have a lower LogP value.,C[C@@H](Oc1ccccc1C#N)C(=O)Oc1ccc(F)cc1,3.0702800000000012
83805,Modify the molecule C[NH2+]C[C@H](C)C(=O)N(C)[C@H](C)c1cccc(Cl)c1 to have a lower LogP value.,C[NH2+]C[C@H](C)C(=O)N(C)[C@H](C)c1cccc(Cl)c1,1.6886999999999999
178477,Modify the molecule N#C[C@H](OC(=O)COc1ccc(I)cc1)C1CC1 to increase its LogP value.,N#C[C@H](OC(=O)COc1ccc(I)cc1)C1CC1,2.5153800000000004
230803,Modify the molecule CCOCCN(C)C(=O)Nc1ccc(-c2nnc(C)o2)cc1 to increase its LogP value.,CCOCCN(C)C(=O)Nc1ccc(-c2nnc(C)o2)cc1,2.5452200000000005
191092,Modify the molecule CC#CCOc1ccc(S(=O)(=O)N2CCOCC2)cc1 to increase its LogP value.,CC#CCOc1ccc(S(=O)(=O)N2CCOCC2)cc1,1.1096
49895,Please optimize the molecule Cc1cc(-c2cc(C(=O)N3CCCN(C(=O)OCC(C)C)CC3)c3cnn(C(C)C)c3n2)c(C)s1 to have a lower LogP value.,Cc1cc(-c2cc(C(=O)N3CCCN(C(=O)OCC(C)C)CC3)c3cnn(C(C)C)c3n2)c(C)s1,5.298040000000006
88503,Modify the molecule C=CCn1c(Sc2nc(CC)ns2)nnc1-c1ccccc1C to have a higher LogP value.,C=CCn1c(Sc2nc(CC)ns2)nnc1-c1ccccc1C,4.004620000000003
213459,Modify the molecule CCCOc1ccc2c(=O)c(-c3cc(C(=O)OC)oc3C)c(C)oc2c1 to have a higher LogP value.,CCCOc1ccc2c(=O)c(-c3cc(C(=O)OC)oc3C)c(C)oc2c1,4.2452400000000035
51404,Please modify the molecule C[C@@H](OC(=O)c1csc(-c2cccs2)n1)[C@H]1CCOC1 to decrease its LogP value.,C[C@@H](OC(=O)c1csc(-c2cccs2)n1)[C@H]1CCOC1,3.453400000000002
195841,Please optimize the molecule CC(C)CNC(=O)C(=O)Nc1cccnc1Br to have a higher LogP value.,CC(C)CNC(=O)C(=O)Nc1cccnc1Br,1.5547999999999995
90396,Please modify the molecule CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl to decrease its LogP value.,CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl,4.240200000000002
122,Please modify the molecule Cc1ccc2ncc(C(=O)Nc3ncccc3OCc3ccncc3)n2c1 to increase its LogP value.,Cc1ccc2ncc(C(=O)Nc3ncccc3OCc3ccncc3)n2c1,3.2640200000000013
215535,Optimize the molecule CC(C)[C@H](C)NC(=O)CS(=O)(=O)Cc1cccc(C(N)=O)c1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)CS(=O)(=O)Cc1cccc(C(N)=O)c1,0.861
29635,Please optimize the molecule Cc1cc(NCCCc2c(C)noc2C)nc(C)[nH+]1 to have a higher LogP value.,Cc1cc(NCCCc2c(C)noc2C)nc(C)[nH+]1,2.16208
85173,Please modify the molecule O=c1c2ccc3c(=O)n(-c4nccs4)c(=O)c4ccc(c(=O)n1-c1nccs1)c2c34 to increase its LogP value.,O=c1c2ccc3c(=O)n(-c4nccs4)c(=O)c4ccc(c(=O)n1-c1nccs1)c2c34,3.354000000000002
78212,Modify the molecule COC(=O)c1occc1CSc1ccc(Cl)cc1N to have a lower LogP value.,COC(=O)c1occc1CSc1ccc(Cl)cc1N,3.594100000000002
238913,Optimize the molecule O=C(CCc1ccc(Cl)s1)Nc1cnn(CC[NH+]2CCCCC2)c1 to have a lower LogP value.,O=C(CCc1ccc(Cl)s1)Nc1cnn(CC[NH+]2CCCCC2)c1,2.2380999999999993
64708,Please modify the molecule CCO[C@H]1C[C@H]1C(=O)Nc1ccccc1-n1ncc2c(=O)[nH]cnc21 to increase its LogP value.,CCO[C@H]1C[C@H]1C(=O)Nc1ccccc1-n1ncc2c(=O)[nH]cnc21,1.4722999999999997
166324,Optimize the molecule CCOC(=O)c1c(C)c(C)cc(C)c1C to have a lower LogP value.,CCOC(=O)c1c(C)c(C)cc(C)c1C,3.096980000000002
51923,Modify the molecule C#CCCOc1ccc(CN2CCC[C@@H](CN3CCOCC3)C2)cc1 to have a lower LogP value.,C#CCCOc1ccc(CN2CCC[C@@H](CN3CCOCC3)C2)cc1,2.632900000000001
245615,Modify the molecule CCN(C(=O)NC1CC[NH+](C2CC2)CC1)C1CCCC1 to decrease its LogP value.,CCN(C(=O)NC1CC[NH+](C2CC2)CC1)C1CCCC1,1.1702000000000006
107354,Optimize the molecule O=C(CCc1ccccc1Cl)NNC(=O)Cc1cccc2ccccc12 to have a higher LogP value.,O=C(CCc1ccccc1Cl)NNC(=O)Cc1cccc2ccccc12,3.815900000000002
4893,Optimize the molecule O=C(Cc1ccc(N(Cc2ccccc2)C(=O)/C=C/c2ccccc2)cc1)N1CCOCC1 to have a lower LogP value.,O=C(Cc1ccc(N(Cc2ccccc2)C(=O)/C=C/c2ccccc2)cc1)N1CCOCC1,4.334500000000004
195282,Modify the molecule CC(C)c1cc(NC(=O)CN(C)CC(C)(C)C[NH3+])on1 to have a lower LogP value.,CC(C)c1cc(NC(=O)CN(C)CC(C)(C)C[NH3+])on1,0.9364000000000006
126994,Please modify the molecule Cc1cccc(C2(NC(=O)[C@H]3CCO[C@@H]3C)CCCC2)c1 to increase its LogP value.,Cc1cccc(C2(NC(=O)[C@H]3CCO[C@@H]3C)CCCC2)c1,3.3055200000000022
30253,Optimize the molecule COC(OCC[NH+]1CCCCC1)(c1ccccc1)c1ccccc1 to have a lower LogP value.,COC(OCC[NH+]1CCCCC1)(c1ccccc1)c1ccccc1,2.6195000000000004
18828,Please optimize the molecule Fc1cccc(-c2nnco2)c1 to have a higher LogP value.,Fc1cccc(-c2nnco2)c1,1.8756999999999997
191117,Modify the molecule COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O to decrease its LogP value.,COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O,4.330500000000003
97769,Please modify the molecule Cc1nn(-c2cccc(Br)c2)c(C)c1[C@@H]1C=C[C@@H]([NH2+]Cc2cccc(C#N)c2)C1 to decrease its LogP value.,Cc1nn(-c2cccc(Br)c2)c(C)c1[C@@H]1C=C[C@@H]([NH2+]Cc2cccc(C#N)c2)C1,4.299020000000003
17139,Please optimize the molecule Cc1c(C(=O)N2CCCC2)sc2nc(-c3cccc([N+](=O)[O-])c3)cn12 to have a higher LogP value.,Cc1c(C(=O)N2CCCC2)sc2nc(-c3cccc([N+](=O)[O-])c3)cn12,3.5154200000000024
85726,Please modify the molecule CC(C)NC(=O)CSc1ccccc1C(=O)N[C@H]1CCCC[C@@H]1C to decrease its LogP value.,CC(C)NC(=O)CSc1ccccc1C(=O)N[C@H]1CCCC[C@@H]1C,3.6118000000000023
76153,Modify the molecule CCOC(=O)c1cc(C#N)c([O-])nc1C(F)(F)F to have a lower LogP value.,CCOC(=O)c1cc(C#N)c([O-])nc1C(F)(F)F,1.22238
62979,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CN1CCN(C2=[NH+]C[C@@H](C)S2)CC1 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)CN1CCN(C2=[NH+]C[C@@H](C)S2)CC1,0.7764199999999999
183178,Please optimize the molecule COc1ccc2c(c1)[C@H]([NH2+][C@H](C)CCN1CCOCC1)CCCO2 to have a higher LogP value.,COc1ccc2c(c1)[C@H]([NH2+][C@H](C)CCN1CCOCC1)CCCO2,1.5831000000000004
232235,Please optimize the molecule CN(C(=O)CC(c1ccccc1)c1ccccc1)C1(C#N)CCC1 to have a higher LogP value.,CN(C(=O)CC(c1ccccc1)c1ccccc1)C1(C#N)CCC1,4.113280000000003
97688,Modify the molecule C=CCNC(=O)c1ccc(COc2ccc(F)cc2)o1 to have a lower LogP value.,C=CCNC(=O)c1ccc(COc2ccc(F)cc2)o1,2.9135000000000018
95208,Modify the molecule O=C(CSc1nnc(Cc2ccccc2)o1)c1cc([N+](=O)[O-])ccc1Cl to have a higher LogP value.,O=C(CSc1nnc(Cc2ccccc2)o1)c1cc([N+](=O)[O-])ccc1Cl,4.197000000000003
197614,Modify the molecule O=C(Nc1ccnn1C1CCCCC1)c1cccc(Cl)c1 to have a lower LogP value.,O=C(Nc1ccnn1C1CCCCC1)c1cccc(Cl)c1,4.294000000000003
66891,Optimize the molecule Cc1cc(Br)ccc1NC(=O)CN(C)S(=O)(=O)c1cccc(C#N)c1 to have a higher LogP value.,Cc1cc(Br)ccc1NC(=O)CN(C)S(=O)(=O)c1cccc(C#N)c1,2.8884000000000007
209475,Modify the molecule CCC[NH+](C)C[C@H]1CCN(C(=O)c2ccc(Cl)c(Cl)c2)C1 to decrease its LogP value.,CCC[NH+](C)C[C@H]1CCN(C(=O)c2ccc(Cl)c(Cl)c2)C1,2.3802000000000003
4245,Optimize the molecule O=C(CSCc1ccccc1)N(Cc1ccsc1)C1CC1 to have a higher LogP value.,O=C(CSCc1ccccc1)N(Cc1ccsc1)C1CC1,4.172500000000003
105792,Please optimize the molecule CCc1nn(C)c(OC)c1CNC(=O)N1CC[C@H](CC)C1 to have a lower LogP value.,CCc1nn(C)c(OC)c1CNC(=O)N1CC[C@H](CC)C1,1.9325999999999997
91905,Modify the molecule O=C(NCCc1ccco1)c1ccc(NC2=N[C@H]3CS(=O)(=O)C[C@H]3S2)cc1 to have a higher LogP value.,O=C(NCCc1ccco1)c1ccc(NC2=N[C@H]3CS(=O)(=O)C[C@H]3S2)cc1,1.9323999999999997
570,Modify the molecule CCc1noc(CN(CC)C(=O)C(C)(C)NC(=O)c2cccs2)n1 to have a higher LogP value.,CCc1noc(CN(CC)C(=O)C(C)(C)NC(=O)c2cccs2)n1,2.2506000000000004
19657,Modify the molecule Cc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1N1CCCC1=O to have a higher LogP value.,Cc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1N1CCCC1=O,2.830820000000001
126711,Modify the molecule O=C(N[C@@H](c1ccc(Cl)cc1)c1ncon1)N(CC1CC1)CC1CC1 to decrease its LogP value.,O=C(N[C@@H](c1ccc(Cl)cc1)c1ncon1)N(CC1CC1)CC1CC1,3.644000000000002
82894,Optimize the molecule Cc1ccc(C[C@@H]([NH3+])CC23CC4CC(CC(C4)C2)C3)cc1 to have a higher LogP value.,Cc1ccc(C[C@@H]([NH3+])CC23CC4CC(CC(C4)C2)C3)cc1,3.754520000000003
197422,Please modify the molecule CC(C)(C)C(=O)NCC(=O)Nc1cc(Cl)ccc1C(=O)[O-] to decrease its LogP value.,CC(C)(C)C(=O)NCC(=O)Nc1cc(Cl)ccc1C(=O)[O-],0.8042999999999997
196509,Please modify the molecule COc1ccc([C@@H](C)COC(=O)c2csc(-c3ncccn3)n2)cc1 to increase its LogP value.,COc1ccc([C@@H](C)COC(=O)c2csc(-c3ncccn3)n2)cc1,3.569200000000002
59011,Modify the molecule CCCc1ccc(OC(=O)C2C[C@H](C)O[C@@H](C)C2)cc1 to decrease its LogP value.,CCCc1ccc(OC(=O)C2C[C@H](C)O[C@@H](C)C2)cc1,3.7481000000000027
199886,Modify the molecule Cc1ccccc1Oc1nc2ccccn2c(=O)c1[N+](=O)[O-] to increase its LogP value.,Cc1ccccc1Oc1nc2ccccn2c(=O)c1[N+](=O)[O-],2.7034200000000004
237156,Please modify the molecule CCOc1ccc2oc(C(=O)N3CCC(C(=O)OC)CC3)c(C)c2c1 to increase its LogP value.,CCOc1ccc2oc(C(=O)N3CCC(C(=O)OC)CC3)c(C)c2c1,3.1651200000000017
55342,Modify the molecule CN(Cc1ccc(Cl)s1)C(=O)CN1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O to have a lower LogP value.,CN(Cc1ccc(Cl)s1)C(=O)CN1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O,3.0043000000000015
233759,Modify the molecule CCC[NH+](C1CC1)[C@@H]1CCC[C@](NC2CC2)(C(N)=O)C1 to increase its LogP value.,CCC[NH+](C1CC1)[C@@H]1CCC[C@](NC2CC2)(C(N)=O)C1,0.3624000000000015
98219,Please optimize the molecule C[C@@H]1CC(=O)C2=C(CC[C@@]3(O)[C@@H](O)c4c(O)cccc4C(=O)[C@H]23)C1 to have a lower LogP value.,C[C@@H]1CC(=O)C2=C(CC[C@@]3(O)[C@@H](O)c4c(O)cccc4C(=O)[C@H]23)C1,2.0586
218375,Optimize the molecule C=CCNC(=O)c1cnn(-c2ncc3c(n2)-c2ccccc2CCC3)c1C1CC1 to have a lower LogP value.,C=CCNC(=O)c1cnn(-c2ncc3c(n2)-c2ccccc2CCC3)c1C1CC1,3.611200000000002
65377,Optimize the molecule COc1ccc([C@@H]2C(C(=O)c3ccc(C)o3)=C([O-])C(=O)N2c2nc3c(C)cc(C)cc3s2)cc1 to have a lower LogP value.,COc1ccc([C@@H]2C(C(=O)c3ccc(C)o3)=C([O-])C(=O)N2c2nc3c(C)cc(C)cc3s2)cc1,4.408360000000004
94167,Please modify the molecule Cn1nc(C(=O)N2C[C@@H](O)C[C@H]2C(=O)[O-])ccc1=O to decrease its LogP value.,Cn1nc(C(=O)N2C[C@@H](O)C[C@H]2C(=O)[O-])ccc1=O,-2.8943999999999983
151281,Please optimize the molecule Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N3CCC[C@@](C)(CO)C3)ccc21 to have a higher LogP value.,Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N3CCC[C@@](C)(CO)C3)ccc21,2.0101999999999993
163338,Modify the molecule Cc1ccc(C[NH2+]C2CCN(C3CC3)CC2)cc1C to increase its LogP value.,Cc1ccc(C[NH2+]C2CCN(C3CC3)CC2)cc1C,1.9936399999999996
50811,Modify the molecule CC(=O)N1CCC[C@@H](C(=O)NCCC[NH+]2CCN(c3cccc(C)c3)CC2)C1 to have a higher LogP value.,CC(=O)N1CCC[C@@H](C(=O)NCCC[NH+]2CCN(c3cccc(C)c3)CC2)C1,0.4647200000000036
181594,Optimize the molecule CCOC(=O)c1[nH]ncc1CN1CCO[C@@H](c2cccc(O)c2)C1 to have a higher LogP value.,CCOC(=O)c1[nH]ncc1CN1CCO[C@@H](c2cccc(O)c2)C1,1.8655000000000002
62596,Optimize the molecule CC[C@H](C)NC(=O)c1cccc(CNC(=O)C(=O)Nc2ccc(F)cc2)c1 to have a lower LogP value.,CC[C@H](C)NC(=O)c1cccc(CNC(=O)C(=O)Nc2ccc(F)cc2)c1,2.6089
63880,Please optimize the molecule Cc1nc(N2CCn3c(nn(C)c3=O)C2)c2c(CC(C)C)csc2n1 to have a higher LogP value.,Cc1nc(N2CCn3c(nn(C)c3=O)C2)c2c(CC(C)C)csc2n1,2.11362
217866,Optimize the molecule NC(=O)c1cc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(F)cc1F to have a lower LogP value.,NC(=O)c1cc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(F)cc1F,3.551700000000001
162054,Modify the molecule C[C@@H]1SCCN(C(=O)[C@@H]2CCC(=O)O2)[C@H]1c1ccccc1 to decrease its LogP value.,C[C@@H]1SCCN(C(=O)[C@@H]2CCC(=O)O2)[C@H]1c1ccccc1,2.3972000000000007
106465,Optimize the molecule O=C(Nc1ccccn1)c1cc2ccc(O)cc2o/c1=[NH+]\c1cccc(F)c1 to have a higher LogP value.,O=C(Nc1ccccn1)c1cc2ccc(O)cc2o/c1=[NH+]\c1cccc(F)c1,2.2378
130525,Please optimize the molecule CC(=O)c1ccc(NC(=O)c2cc3occc3n2C)cc1 to have a higher LogP value.,CC(=O)c1ccc(NC(=O)c2cc3occc3n2C)cc1,3.2262000000000013
58432,Optimize the molecule CCOc1ccc(N(Cc2nc3nc(C)cc([O-])n3n2)C(=O)c2cccc(C)c2)cc1 to have a lower LogP value.,CCOc1ccc(N(Cc2nc3nc(C)cc([O-])n3n2)C(=O)c2cccc(C)c2)cc1,3.0604400000000016
133171,Please optimize the molecule CCCCNC(=O)NC[C@H](OC)c1ccc(F)cc1 to have a higher LogP value.,CCCCNC(=O)NC[C@H](OC)c1ccc(F)cc1,2.6125000000000007
92962,Please optimize the molecule O=C(CN1CCCOC1=O)NCc1cccnc1 to have a lower LogP value.,O=C(CN1CCCOC1=O)NCc1cccnc1,0.5400999999999998
15046,Please optimize the molecule [NH3+][C@@H](c1ccc(F)c(F)c1F)c1csc2ccccc12 to have a lower LogP value.,[NH3+][C@@H](c1ccc(F)c(F)c1F)c1csc2ccccc12,3.6499000000000006
111315,Optimize the molecule C[C@@H]1CN(C2CCN(c3c(C#N)cnc4ccc(Cl)cc34)CC2)CCO1 to have a higher LogP value.,C[C@@H]1CN(C2CCN(c3c(C#N)cnc4ccc(Cl)cc34)CC2)CCO1,3.4493800000000023
171310,Modify the molecule O=C(Cc1ccc(Cl)c(Cl)c1)N1CCC(CN2CCOCC2)CC1 to have a lower LogP value.,O=C(Cc1ccc(Cl)c(Cl)c1)N1CCC(CN2CCOCC2)CC1,3.106700000000002
78531,Please modify the molecule Cc1csc(N(C(=O)c2cccc(NC(=O)CCn3cc[nH+]c3)c2)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)c2cccc(NC(=O)CCn3cc[nH+]c3)c2)c2ccccc2)n1,4.074420000000002
151298,Optimize the molecule COC(=O)[C@H](C)Sc1nnc(N2CCC[C@@H](C)C2)n1Cc1ccco1 to have a lower LogP value.,COC(=O)[C@H](C)Sc1nnc(N2CCC[C@@H](C)C2)n1Cc1ccco1,2.8093000000000012
148928,Modify the molecule CNC(=O)[C@@H](C)NC(=O)c1cccc(C(F)(F)F)c1F to have a higher LogP value.,CNC(=O)[C@@H](C)NC(=O)c1cccc(C(F)(F)F)c1F,1.7087999999999997
206776,Optimize the molecule CCc1nn(C)cc1NC(=O)N(CCO)C1CC1 to have a lower LogP value.,CCc1nn(C)cc1NC(=O)N(CCO)C1CC1,0.9710999999999999
230827,Optimize the molecule CC1=C(/C=C/C(C)=N/NC(N)=[NH2+])C(C)(C)CCC1 to have a higher LogP value.,CC1=C(/C=C/C(C)=N/NC(N)=[NH2+])C(C)(C)CCC1,1.1085
214957,Modify the molecule Cc1csc(N(C(=O)CN2C(=O)N[C@@]3(CCc4ccccc43)C2=O)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)CN2C(=O)N[C@@]3(CCc4ccccc43)C2=O)c2ccccc2)n1,3.5097200000000024
232839,Optimize the molecule COc1ccccc1CNC(=O)[C@H]1CCCN(C(=O)c2cnn(-c3ccccc3)c2-n2cccc2)C1 to have a lower LogP value.,COc1ccccc1CNC(=O)[C@H]1CCCN(C(=O)c2cnn(-c3ccccc3)c2-n2cccc2)C1,3.840200000000003
42491,Modify the molecule Cc1cc(N2CCO[C@@H](c3ccc(F)c(F)c3)C2)ncc1[N+](=O)[O-] to have a higher LogP value.,Cc1cc(N2CCO[C@@H](c3ccc(F)c(F)c3)C2)ncc1[N+](=O)[O-],3.154320000000002
193677,Modify the molecule COc1ccc(C[NH+]2CCNC(=O)[C@@H]2CC(N)=O)cc1C to increase its LogP value.,COc1ccc(C[NH+]2CCNC(=O)[C@@H]2CC(N)=O)cc1C,-1.2376799999999966
93812,Modify the molecule COc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(OC(C)C)c(OC)c2)C3)cc1Cl to increase its LogP value.,COc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(OC(C)C)c(OC)c2)C3)cc1Cl,5.148700000000005
68255,Modify the molecule Cc1cc(N2CCCCC2)nc(NCCNC(=O)Nc2ccc(C)c(Cl)c2)n1 to increase its LogP value.,Cc1cc(N2CCCCC2)nc(NCCNC(=O)Nc2ccc(C)c(Cl)c2)n1,3.970740000000002
117154,Modify the molecule CCO[C@@H](C)c1noc(CN(C)Cc2c(F)cccc2Cl)n1 to increase its LogP value.,CCO[C@@H](C)c1noc(CN(C)Cc2c(F)cccc2Cl)n1,3.5916000000000023
57209,Optimize the molecule O=C([O-])[C@@H](Cc1cccc(F)c1)[C@H]1CCCCC[C@@H]1O to have a higher LogP value.,O=C([O-])[C@@H](Cc1cccc(F)c1)[C@H]1CCCCC[C@@H]1O,1.6754999999999993
213615,Modify the molecule COc1ccc(-c2c(=O)n(OC)c3ccccc3[n+]2[O-])cc1 to increase its LogP value.,COc1ccc(-c2c(=O)n(OC)c3ccccc3[n+]2[O-])cc1,1.3689
202335,Please optimize the molecule Cc1ccc2c(c1)N(C)C(=O)[C@](C)(C(=O)Nc1cccc(C)n1)O2 to have a lower LogP value.,Cc1ccc2c(c1)N(C)C(=O)[C@](C)(C(=O)Nc1cccc(C)n1)O2,2.45104
72418,Please optimize the molecule CCn1nc(C)c(CNC(=O)C2CCN(C(=O)/C=C/c3ccccc3)CC2)c1C to have a lower LogP value.,CCn1nc(C)c(CNC(=O)C2CCN(C(=O)/C=C/c3ccccc3)CC2)c1C,3.0880400000000012
118076,Please modify the molecule COc1ccccc1-c1cc(C(=O)Nc2ccc(C)cn2)no1 to increase its LogP value.,COc1ccccc1-c1cc(C(=O)Nc2ccc(C)cn2)no1,3.3059200000000004
84161,Please modify the molecule CC(C)c1c(C(=O)NCCO)nnn1Cc1ccccc1 to decrease its LogP value.,CC(C)c1c(C(=O)NCCO)nnn1Cc1ccccc1,1.1718999999999995
40278,Please optimize the molecule Cc1cc(C)cc(N(CC(=O)NCC(C)C)S(C)(=O)=O)c1 to have a higher LogP value.,Cc1cc(C)cc(N(CC(=O)NCC(C)C)S(C)(=O)=O)c1,1.84164
115430,Please optimize the molecule Fc1cccc(F)c1N[C@@H]1CCOC2(CCCC2)C1 to have a lower LogP value.,Fc1cccc(F)c1N[C@@H]1CCOC2(CCCC2)C1,3.8685000000000027
227036,Please optimize the molecule COc1ccc(CN2C(=O)[C@@H]([NH3+])[C@H]2[C@H]2COC(C)(C)O2)cc1OC to have a higher LogP value.,COc1ccc(CN2C(=O)[C@@H]([NH3+])[C@H]2[C@H]2COC(C)(C)O2)cc1OC,0.17660000000000187
69065,Please modify the molecule Cc1cc2cc(/C(N)=N/O)c(=O)[nH]c2cc1C to increase its LogP value.,Cc1cc2cc(/C(N)=N/O)c(=O)[nH]c2cc1C,1.2394399999999999
177497,Please modify the molecule O=S(=O)(c1ccc(Br)cc1)N1CCN(C2CC2)C[C@@H]1c1ccccc1 to decrease its LogP value.,O=S(=O)(c1ccc(Br)cc1)N1CCN(C2CC2)C[C@@H]1c1ccccc1,3.659100000000003
224493,Please optimize the molecule CC(C)[C@H]1CCC[NH+]([C@@H](C)[C@@H](C)C[NH3+])CC1 to have a lower LogP value.,CC(C)[C@H]1CCC[NH+]([C@@H](C)[C@@H](C)C[NH3+])CC1,0.5939000000000028
105104,Please optimize the molecule O=C(CN1C(=O)S/C(=C\c2cccn2-c2ccc(O)cc2)C1=O)N1CCN(c2ccccc2)CC1 to have a lower LogP value.,O=C(CN1C(=O)S/C(=C\c2cccn2-c2ccc(O)cc2)C1=O)N1CCN(c2ccccc2)CC1,3.5680000000000023
93217,Please modify the molecule O=Cc1ccc(OCCC(=O)Nc2cccnc2-n2cccn2)cc1 to decrease its LogP value.,O=Cc1ccc(OCCC(=O)Nc2cccnc2-n2cccn2)cc1,2.4874
53180,Please modify the molecule COCc1cccc(CNC(=O)Cn2ccc(=O)[nH]c2=O)c1 to decrease its LogP value.,COCc1cccc(CNC(=O)Cn2ccc(=O)[nH]c2=O)c1,-0.0005999999999996564
33205,Please optimize the molecule CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1ccc(N2CCCC2=O)cc1 to have a higher LogP value.,CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1ccc(N2CCCC2=O)cc1,4.9287000000000045
200536,Modify the molecule Cc1ccc(C(=O)N2CCN(C(=O)C3(c4cccc(Cl)c4)CC3)CC2)s1 to have a lower LogP value.,Cc1ccc(C(=O)N2CCN(C(=O)C3(c4cccc(Cl)c4)CC3)CC2)s1,3.7261200000000034
52132,Optimize the molecule C[C@H]1c2[nH]c3ccccc3c2CCN1C(=O)NCCS(=O)(=O)c1ccccc1 to have a lower LogP value.,C[C@H]1c2[nH]c3ccccc3c2CCN1C(=O)NCCS(=O)(=O)c1ccccc1,3.270500000000002
68606,Modify the molecule O=C(Cc1cccnc1)NCc1cc2n(n1)CC[NH+](C1CCCCC1)C2 to decrease its LogP value.,O=C(Cc1cccnc1)NCc1cc2n(n1)CC[NH+](C1CCCCC1)C2,0.8681999999999999
50522,Modify the molecule CC1CC[NH+]([C@@H](CNC(=O)Nc2ccc([C@H](C)N3CCOCC3)cc2)C(C)C)CC1 to increase its LogP value.,CC1CC[NH+]([C@@H](CNC(=O)Nc2ccc([C@H](C)N3CCOCC3)cc2)C(C)C)CC1,2.540700000000001
26335,Please modify the molecule O=C1C[C@@H](c2ccccc2[N+](=O)[O-])c2ccc3ccccc3c2N1 to increase its LogP value.,O=C1C[C@@H](c2ccccc2[N+](=O)[O-])c2ccc3ccccc3c2N1,4.222100000000002
7152,Modify the molecule COc1ncccc1-c1cc(C)ccc1N1CCOC1=O to have a higher LogP value.,COc1ncccc1-c1cc(C)ccc1N1CCOC1=O,3.0222200000000017
185866,Modify the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(C)c(Cl)c1 to have a lower LogP value.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(C)c(Cl)c1,2.37052
88141,Optimize the molecule Cc1c(N2CCCC[C@@H]2c2cn[nH]c2)cc(C#N)cc1[N+](=O)[O-] to have a lower LogP value.,Cc1c(N2CCCC[C@@H]2c2cn[nH]c2)cc(C#N)cc1[N+](=O)[O-],3.2296000000000014
41729,Modify the molecule COc1ccc(C(=O)Cn2nc(-c3ccc(SC)cc3)ccc2=O)cc1OC to decrease its LogP value.,COc1ccc(C(=O)Cn2nc(-c3ccc(SC)cc3)ccc2=O)cc1OC,3.532300000000002
104528,Please optimize the molecule COc1ccc([C@@H]2CCCN2C(=O)CCCn2cnc3c2c(=O)n(C)c(=O)n3C)cc1 to have a lower LogP value.,COc1ccc([C@@H]2CCCN2C(=O)CCCn2cnc3c2c(=O)n(C)c(=O)n3C)cc1,1.5861999999999996
47679,Modify the molecule C[C@H](C(=O)Nc1ccc(C#N)cc1)[NH+](C)CC(=O)Nc1cccc2ccccc12 to have a lower LogP value.,C[C@H](C(=O)Nc1ccc(C#N)cc1)[NH+](C)CC(=O)Nc1cccc2ccccc12,2.1918800000000003
77650,Modify the molecule CSCc1ccc(C(=O)N[C@@H](Cc2c[nH+]c[nH]2)C(=O)[O-])o1 to have a lower LogP value.,CSCc1ccc(C(=O)N[C@@H](Cc2c[nH+]c[nH]2)C(=O)[O-])o1,-0.6241999999999988
140022,Optimize the molecule NC(=O)CN1C(=O)[C@]2(CCN(C(=O)c3cn[nH]n3)C2)c2ccccc21 to have a higher LogP value.,NC(=O)CN1C(=O)[C@]2(CCN(C(=O)c3cn[nH]n3)C2)c2ccccc21,-0.5794999999999981
96143,Please modify the molecule CC(C)(C)c1ccc(/C=C/C(=O)N2CC(=O)Nc3ccccc32)cc1 to increase its LogP value.,CC(C)(C)c1ccc(/C=C/C(=O)N2CC(=O)Nc3ccccc32)cc1,3.9826000000000032
101116,Modify the molecule COc1cccc(C(=O)NCC(=O)Nc2ccon2)c1 to have a higher LogP value.,COc1cccc(C(=O)NCC(=O)Nc2ccon2)c1,1.0516999999999996
120517,Please modify the molecule CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(C(F)(F)F)ccc3Cl)n2)cc1 to increase its LogP value.,CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(C(F)(F)F)ccc3Cl)n2)cc1,4.619900000000003
97191,Please optimize the molecule C[NH+]1CCN(c2nc(C(=O)NC3CCCC3)cs2)CC1 to have a higher LogP value.,C[NH+]1CCN(c2nc(C(=O)NC3CCCC3)cs2)CC1,0.15020000000000078
157468,Modify the molecule Nc1ccccc1C(=O)CCN1C(=O)c2ccccc2C1=O to increase its LogP value.,Nc1ccccc1C(=O)CCN1C(=O)c2ccccc2C1=O,2.1378000000000004
185451,Optimize the molecule CC[NH+]1CCOC(=O)[C@H]1CC(=O)Nc1ccc2c(c1)OCCO2 to have a lower LogP value.,CC[NH+]1CCOC(=O)[C@H]1CC(=O)Nc1ccc2c(c1)OCCO2,-0.3833999999999991
176578,Please optimize the molecule COc1ccc(Cl)c2sc(N(Cc3ccncc3)C(=O)[C@H]3CCCN3S(C)(=O)=O)nc12 to have a higher LogP value.,COc1ccc(Cl)c2sc(N(Cc3ccncc3)C(=O)[C@H]3CCCN3S(C)(=O)=O)nc12,3.310500000000002
231751,Optimize the molecule Cc1cnc(CCN(C)C(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)s1 to have a higher LogP value.,Cc1cnc(CCN(C)C(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)s1,3.905820000000003
37033,Please optimize the molecule CN(Cc1[nH]c(-c2ccccc2)c[nH+]1)[C@@H]1CCCC[C@@H]1O to have a higher LogP value.,CN(Cc1[nH]c(-c2ccccc2)c[nH+]1)[C@@H]1CCCC[C@@H]1O,2.231100000000001
219581,Please modify the molecule Fc1cccc([C@@H]2N[C@H](c3nccs3)Cc3ccsc32)c1F to decrease its LogP value.,Fc1cccc([C@@H]2N[C@H](c3nccs3)Cc3ccsc32)c1F,4.459200000000002
110056,Optimize the molecule Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1 to have a lower LogP value.,Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1,4.075280000000003
60619,Modify the molecule COc1ccc(SCc2nc3ccc(Cl)cc3c(=O)[nH]2)cc1 to increase its LogP value.,COc1ccc(SCc2nc3ccc(Cl)cc3c(=O)[nH]2)cc1,3.8774000000000024
31235,Please optimize the molecule Cc1nc(N(C)C)sc1C[NH+](C)[C@H]1CCCc2c1cnn2C to have a lower LogP value.,Cc1nc(N(C)C)sc1C[NH+](C)[C@H]1CCCc2c1cnn2C,1.3433199999999994
41007,Please modify the molecule C[C@@H]([NH+]1CCC(n2cccc2C(=O)[O-])CC1)C1(C)CC1 to decrease its LogP value.,C[C@@H]([NH+]1CCC(n2cccc2C(=O)[O-])CC1)C1(C)CC1,0.26
46752,Please modify the molecule O=c1occ(CN2CCN(c3ccccc3)CC2)c([O-])c1CN1CCOCC1 to decrease its LogP value.,O=c1occ(CN2CCN(c3ccccc3)CC2)c([O-])c1CN1CCOCC1,0.8677999999999999
47940,Optimize the molecule C[C@@H]1C[C@@H]2CCCC[C@@H]2[NH+]1Cc1n[nH]c(=O)[nH]1 to have a lower LogP value.,C[C@@H]1C[C@@H]2CCCC[C@@H]2[NH+]1Cc1n[nH]c(=O)[nH]1,-0.1660999999999987
135193,Please modify the molecule Cc1cc(F)ccc1CCNC(=O)C(=O)Nc1nn(C(C)C)cc1C#N to decrease its LogP value.,Cc1cc(F)ccc1CCNC(=O)C(=O)Nc1nn(C(C)C)cc1C#N,2.0805999999999996
3408,Please optimize the molecule Cc1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1S(=O)(=O)N1CCOCC1 to have a lower LogP value.,Cc1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1S(=O)(=O)N1CCOCC1,2.506920000000001
136475,Modify the molecule CCN(Cc1ccccc1)S(=O)(=O)[C@H]1C=NC(C(=O)OC)=C1 to have a higher LogP value.,CCN(Cc1ccccc1)S(=O)(=O)[C@H]1C=NC(C(=O)OC)=C1,1.3482
51657,Please modify the molecule O=C(N/N=C\c1ccc(OCc2cccc(F)c2)cc1)c1cccs1 to increase its LogP value.,O=C(N/N=C\c1ccc(OCc2cccc(F)c2)cc1)c1cccs1,4.230100000000003
198012,Optimize the molecule C[C@@H]1CCC[C@@H]1NC(=O)C(=O)Nc1ccc(COc2ccccc2)cc1 to have a lower LogP value.,C[C@@H]1CCC[C@@H]1NC(=O)C(=O)Nc1ccc(COc2ccccc2)cc1,3.5089000000000024
179973,Modify the molecule COc1ccc(F)c(N[C@H](C[NH3+])C2CCCCC2)c1 to decrease its LogP value.,COc1ccc(F)c(N[C@H](C[NH3+])C2CCCCC2)c1,2.4370000000000003
248327,Please optimize the molecule CC[NH+](CC)C(C)(C)C(=O)Cc1ccc(C)c(C)c1 to have a higher LogP value.,CC[NH+](CC)C(C)(C)C(=O)Cc1ccc(C)c(C)c1,2.11834
101513,Please optimize the molecule C[C@H]1Sc2ccc(C(=O)NCc3ccc4c(n3)CCCC4=O)cc2NC1=O to have a lower LogP value.,C[C@H]1Sc2ccc(C(=O)NCc3ccc4c(n3)CCCC4=O)cc2NC1=O,2.963300000000001
5301,Modify the molecule CN(Cc1nccn1Cc1ccccc1)C(=O)c1ccc(C(N)=O)cc1 to increase its LogP value.,CN(Cc1nccn1Cc1ccccc1)C(=O)c1ccc(C(N)=O)cc1,2.3025
58150,Modify the molecule Cc1cc(CNS(=O)(=O)CC(C)C)c(C)o1 to have a lower LogP value.,Cc1cc(CNS(=O)(=O)CC(C)C)c(C)o1,1.97184
91813,Please modify the molecule CC[NH2+][C@H](c1cc(C)oc1C)C1(CC)CCCC1 to increase its LogP value.,CC[NH2+][C@H](c1cc(C)oc1C)C1(CC)CCCC1,3.491240000000002
165059,Modify the molecule Cc1cc2c(SCC(=O)N[C@H](C)C(=O)N(C)C)ncnc2s1 to have a higher LogP value.,Cc1cc2c(SCC(=O)N[C@H](C)C(=O)N(C)C)ncnc2s1,1.6847199999999996
140542,Please optimize the molecule CCC[NH2+][C@H](CC(F)(F)F)[C@@H]1CCCc2cccnc21 to have a lower LogP value.,CCC[NH2+][C@H](CC(F)(F)F)[C@@H]1CCCc2cccnc21,2.7959000000000014
112915,Modify the molecule COC(=O)[C@@H](NC[C@H]1CCCO1)c1ccccc1Cl to have a higher LogP value.,COC(=O)[C@@H](NC[C@H]1CCCO1)c1ccccc1Cl,2.3226999999999993
64320,Please optimize the molecule Nc1nc2n(n1)[C@H](c1ccccc1Br)C1=C(C[C@@H](c3cccs3)CC1=O)N2 to have a lower LogP value.,Nc1nc2n(n1)[C@H](c1ccccc1Br)C1=C(C[C@@H](c3cccs3)CC1=O)N2,4.100000000000002
103104,Modify the molecule CC1=C(C(N)=O)[C@H](c2cccs2)N2NC(c3ccccc3Cl)=NC2=N1 to decrease its LogP value.,CC1=C(C(N)=O)[C@H](c2cccs2)N2NC(c3ccccc3Cl)=NC2=N1,2.8385000000000007
147238,Please optimize the molecule COc1ccc([C@@H]2C[C@H](C)N(C(=O)c3cc(F)ccc3C)C2)cc1 to have a lower LogP value.,COc1ccc([C@@H]2C[C@H](C)N(C(=O)c3cc(F)ccc3C)C2)cc1,4.1609200000000035
210904,Please optimize the molecule CC(C)(CNC(=O)NCc1c(F)cccc1OC(F)F)c1ccncc1 to have a lower LogP value.,CC(C)(CNC(=O)NCc1c(F)cccc1OC(F)F)c1ccncc1,3.5991000000000026
189967,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](c3ncc[nH]3)C2)C1 to decrease its LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](c3ncc[nH]3)C2)C1,1.8190999999999997
219895,Modify the molecule COC[C@@H](O)CN1CCC([NH2+][C@H]2CC[C@@H](C)C2)CC1 to increase its LogP value.,COC[C@@H](O)CN1CCC([NH2+][C@H]2CC[C@@H](C)C2)CC1,0.21010000000000173
42296,Optimize the molecule COc1cccc(CNC(=O)C[C@@H]2CSc3nc4c(cnn4-c4cccc(Cl)c4)c(=O)n32)c1 to have a higher LogP value.,COc1cccc(CNC(=O)C[C@@H]2CSc3nc4c(cnn4-c4cccc(Cl)c4)c(=O)n32)c1,3.597500000000002
202897,Modify the molecule COC(=O)CSc1nc2[nH]ncc2c(=O)n1-c1ccccc1 to increase its LogP value.,COC(=O)CSc1nc2[nH]ncc2c(=O)n1-c1ccccc1,1.3738999999999997
65204,Modify the molecule COc1ccccc1NC(=O)N1CCC(Oc2ccccc2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)N1CCC(Oc2ccccc2)CC1,3.770500000000003
4035,Please modify the molecule O=C(N=C1NCCCCCN1)c1ccc(Br)cc1 to increase its LogP value.,O=C(N=C1NCCCCCN1)c1ccc(Br)cc1,2.3084
108909,Modify the molecule Cc1nc(C[NH+]2CCC[C@H](NCCOc3ccccc3C)C2)no1 to have a lower LogP value.,Cc1nc(C[NH+]2CCC[C@H](NCCOc3ccccc3C)C2)no1,0.9023400000000013
211486,Optimize the molecule O=C(NCc1cc2ccccc2o1)C(=O)Nc1ccc(F)c(F)c1F to have a higher LogP value.,O=C(NCc1cc2ccccc2o1)C(=O)Nc1ccc(F)c(F)c1F,3.1050000000000004
125884,Optimize the molecule CCc1nc([C@H](C)NC(=O)c2nc(C3CC3)n3ccccc23)cs1 to have a lower LogP value.,CCc1nc([C@H](C)NC(=O)c2nc(C3CC3)n3ccccc23)cs1,3.7216000000000022
193385,Please modify the molecule COCCCN1C(=O)CC[C@@H](C(=O)[O-])[C@@H]1c1ccc(F)cc1 to decrease its LogP value.,COCCCN1C(=O)CC[C@@H](C(=O)[O-])[C@@H]1c1ccc(F)cc1,0.8918000000000001
7037,Please optimize the molecule CC(C)N(C(=O)CSC(=S)N1CCCCC1)C(C)C to have a lower LogP value.,CC(C)N(C(=O)CSC(=S)N1CCCCC1)C(C)C,3.1358000000000015
14866,Modify the molecule COc1ccc([C@@H]2CCCCCN2C(=O)Cn2ccccc2=O)cc1 to have a lower LogP value.,COc1ccc([C@@H]2CCCCCN2C(=O)Cn2ccccc2=O)cc1,3.0008000000000017
208417,Modify the molecule O=c1[nH]c(CCl)nc2ccc(O)cc12 to increase its LogP value.,O=c1[nH]c(CCl)nc2ccc(O)cc12,1.3675
123715,Modify the molecule CC1CCN(S(=O)(=O)c2ccc(C(=O)N(C)Cc3cccc(Cl)c3)cc2)CC1 to decrease its LogP value.,CC1CCN(S(=O)(=O)c2ccc(C(=O)N(C)Cc3cccc(Cl)c3)cc2)CC1,4.0328000000000035
106002,Please modify the molecule Cn1ccnc1S[C@H]1CC[C@@](C#N)(NC2CC2)C1 to increase its LogP value.,Cn1ccnc1S[C@H]1CC[C@@](C#N)(NC2CC2)C1,2.0790800000000003
104623,Modify the molecule COc1ccc(CN2CC[NH+](CC(C)C)[C@H](CCO)C2)c(C)c1C to have a lower LogP value.,COc1ccc(CN2CC[NH+](CC(C)C)[C@H](CCO)C2)c(C)c1C,1.4195400000000007
22270,Modify the molecule CC1(C)[C@H](N2CCOCC2)[C@H](Cl)S1(=O)=O to have a higher LogP value.,CC1(C)[C@H](N2CCOCC2)[C@H](Cl)S1(=O)=O,0.4591000000000003
54842,Modify the molecule CNC(=O)[C@@H](CC(C)C)N[C@H](C)C[C@@H]1CCCCC[NH2+]1 to have a higher LogP value.,CNC(=O)[C@@H](CC(C)C)N[C@H](C)C[C@@H]1CCCCC[NH2+]1,1.021300000000001
153449,Optimize the molecule Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F to have a lower LogP value.,Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F,2.614040000000001
32898,Modify the molecule OC[C@H](C[C@H]1CCCO1)c1ccccc1F to increase its LogP value.,OC[C@H](C[C@H]1CCCO1)c1ccccc1F,2.470700000000001
186346,Modify the molecule CCn1nc(C)cc1C(=O)NCC(=O)NCc1cccnc1 to decrease its LogP value.,CCn1nc(C)cc1C(=O)NCC(=O)NCc1cccnc1,0.6526199999999993
177140,Please modify the molecule Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1,2.4674200000000006
237660,Modify the molecule C[C@H]1Cc2ccccc2N1C(=O)CNCC[NH+](C)C to have a higher LogP value.,C[C@H]1Cc2ccccc2N1C(=O)CNCC[NH+](C)C,-0.3016999999999974
222127,Modify the molecule COc1ccccc1NC(=O)C[NH+]1CCC(c2nc3ccccc3[nH]2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)C[NH+]1CCC(c2nc3ccccc3[nH]2)CC1,1.9724999999999993
110735,Modify the molecule O=C(c1nn2c(c1Cl)N[C@H](c1ccc(Br)cc1)C[C@@H]2C(F)(F)F)N1CCOCC1 to have a lower LogP value.,O=C(c1nn2c(c1Cl)N[C@H](c1ccc(Br)cc1)C[C@@H]2C(F)(F)F)N1CCOCC1,4.431700000000003
121046,Modify the molecule CCCc1n[nH]c2c1[C@@H](c1ccc(SC)cc1)C(C#N)=C(N)O2 to decrease its LogP value.,CCCc1n[nH]c2c1[C@@H](c1ccc(SC)cc1)C(C#N)=C(N)O2,3.3022800000000014
209988,Modify the molecule O=C(c1cnc(Nc2ccccc2)nc1)N1CCC2(CC[NH2+]CC2)CC1 to decrease its LogP value.,O=C(c1cnc(Nc2ccccc2)nc1)N1CCC2(CC[NH2+]CC2)CC1,1.7997999999999996
221667,Optimize the molecule Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1 to have a higher LogP value.,Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1,3.0597600000000007
226882,Please modify the molecule CSc1cccc(NC(=O)[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C[C@H](C)N3C(C)=O)c1 to decrease its LogP value.,CSc1cccc(NC(=O)[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C[C@H](C)N3C(C)=O)c1,3.4978000000000025
117911,Modify the molecule O=C(C1=C([O-])C(=O)N(c2cccc(C(F)(F)F)c2)[C@@H]1c1cccc([N+](=O)[O-])c1)c1ccccc1 to have a higher LogP value.,O=C(C1=C([O-])C(=O)N(c2cccc(C(F)(F)F)c2)[C@@H]1c1cccc([N+](=O)[O-])c1)c1ccccc1,4.198800000000003
230216,Please modify the molecule O=C1C[C@H](c2cccc(O)c2)[C@@H]2C(=O)N=C(SCc3ccc(F)cc3)N=C2N1 to decrease its LogP value.,O=C1C[C@H](c2cccc(O)c2)[C@@H]2C(=O)N=C(SCc3ccc(F)cc3)N=C2N1,2.9791000000000007
194593,Modify the molecule CCN(C[C@H](C)C(=O)OC)C(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C to have a lower LogP value.,CCN(C[C@H](C)C(=O)OC)C(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C,2.791260000000001
157356,Please modify the molecule CCc1nc(CNC(=O)c2ccc(C)nc2)cs1 to increase its LogP value.,CCc1nc(CNC(=O)c2ccc(C)nc2)cs1,2.3389200000000008
22605,Please modify the molecule CC[C@@H](NC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)c1ccc(C)cc1 to decrease its LogP value.,CC[C@@H](NC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)c1ccc(C)cc1,2.689520000000001
140692,Please optimize the molecule COC(=O)[C@H](Nc1ncnc(OC(C)C)c1N)C(C)C to have a higher LogP value.,COC(=O)[C@H](Nc1ncnc(OC(C)C)c1N)C(C)C,1.4554999999999991
235042,Modify the molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)[C@H](C)c1cccs1)C2 to increase its LogP value.,Cc1cn2c([nH+]1)CC[C@H](NC(=O)[C@H](C)c1cccs1)C2,1.9068199999999993
19720,Modify the molecule CC[C@@H](Nc1cc(C)ccc1N)c1cccs1 to have a lower LogP value.,CC[C@@H](Nc1cc(C)ccc1N)c1cccs1,4.201920000000003
56523,Optimize the molecule CC(C)C[C@@H]1NC(=O)[C@H]2CN(Cc3cccc4ncccc34)CCN2C1=O to have a lower LogP value.,CC(C)C[C@@H]1NC(=O)[C@H]2CN(Cc3cccc4ncccc34)CCN2C1=O,1.7920999999999996
149613,Please optimize the molecule CC[NH2+][C@@H]1[C@H](CN(C)Cc2ccccn2)CCC1(C)C to have a lower LogP value.,CC[NH2+][C@@H]1[C@H](CN(C)Cc2ccccn2)CCC1(C)C,1.9015
202160,Please modify the molecule CC(C)[C@@H](CS)CN1C(=O)CC(C)(C)C1=O to increase its LogP value.,CC(C)[C@@H](CS)CN1C(=O)CC(C)(C)C1=O,1.9735
36657,Optimize the molecule COC(=O)[C@@H]1CN(C(=O)c2ncccc2[O-])C[C@H]1C to have a higher LogP value.,COC(=O)[C@@H]1CN(C(=O)c2ncccc2[O-])C[C@H]1C,0.036299999999999555
99600,Please modify the molecule COC(=O)c1ccc(NC(=O)CN2CCN(c3ccccc3F)CC2)cc1 to decrease its LogP value.,COC(=O)c1ccc(NC(=O)CN2CCN(c3ccccc3F)CC2)cc1,2.373
160493,Optimize the molecule Cc1cccc(-n2c(SCC(N)=O)nc3sc(C)c(C)c3c2=O)c1C to have a higher LogP value.,Cc1cccc(-n2c(SCC(N)=O)nc3sc(C)c(C)c3c2=O)c1C,3.258280000000002
162175,Please optimize the molecule O=C(NNC(=O)c1ccnc2ccccc12)c1ccc(Cl)cc1 to have a higher LogP value.,O=C(NNC(=O)c1ccnc2ccccc12)c1ccc(Cl)cc1,2.963000000000001
10502,Please modify the molecule CC(=O)N[C@@H](CC(=O)Nc1ccccc1I)c1ccccc1 to decrease its LogP value.,CC(=O)N[C@@H](CC(=O)Nc1ccccc1I)c1ccccc1,3.497200000000002
246036,Please optimize the molecule COc1ccc(C[NH+]2CCC[C@@H]([NH+]3CCCC3)C2)cc1SC to have a lower LogP value.,COc1ccc(C[NH+]2CCC[C@@H]([NH+]3CCCC3)C2)cc1SC,0.6431000000000013
83451,Please optimize the molecule O=C([C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1)N1CCc2ccccc21 to have a lower LogP value.,O=C([C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1)N1CCc2ccccc21,1.8603
54042,Modify the molecule COc1ccc(-c2n[nH]c(S[C@H](C)C(=O)Nc3cc(Cl)ccc3OC)n2)cc1 to decrease its LogP value.,COc1ccc(-c2n[nH]c(S[C@H](C)C(=O)Nc3cc(Cl)ccc3OC)n2)cc1,4.261600000000002
14148,Modify the molecule CCOC(=O)/C(CC)=C(\C)NNC(=O)c1ccccc1I to decrease its LogP value.,CCOC(=O)/C(CC)=C(\C)NNC(=O)c1ccccc1I,2.7727000000000013
88625,Modify the molecule O=C1c2cccc3c(N4CCCC4)ccc(c23)C(=O)N1CCc1ccccc1 to have a higher LogP value.,O=C1c2cccc3c(N4CCCC4)ccc(c23)C(=O)N1CCc1ccccc1,4.278700000000004
202858,Optimize the molecule COc1ccc(Cl)cc1NC(=O)/C(C#N)=C/c1ccc(N2CCOCC2)o1 to have a higher LogP value.,COc1ccc(Cl)cc1NC(=O)/C(C#N)=C/c1ccc(N2CCOCC2)o1,3.3238800000000017
192146,Optimize the molecule CCn1nc(C(C)C)cc1C(=O)OCC(=O)N1CCCCCC1 to have a lower LogP value.,CCn1nc(C(C)C)cc1C(=O)OCC(=O)N1CCCCCC1,2.5858000000000008
200845,Modify the molecule COc1ccc(Cl)cc1NC(=O)c1c(-n2cnnn2)sc2c1CCC2 to decrease its LogP value.,COc1ccc(Cl)cc1NC(=O)c1c(-n2cnnn2)sc2c1CCC2,3.126800000000001
141861,Please modify the molecule O=C(COc1ccc(F)cc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1 to increase its LogP value.,O=C(COc1ccc(F)cc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1,3.590900000000002
139333,Modify the molecule COCC[C@]1(C)CC(=O)NC(=O)[C@H]1c1cccc(C)c1 to decrease its LogP value.,COCC[C@]1(C)CC(=O)NC(=O)[C@H]1c1cccc(C)c1,2.1679199999999996
166695,Modify the molecule O=C(C=C1CCSCC1)Nc1ccc(Cl)c(Cl)c1 to decrease its LogP value.,O=C(C=C1CCSCC1)Nc1ccc(Cl)c(Cl)c1,4.385300000000003
182487,Modify the molecule N#C[C@H](NS(=O)(=O)c1ccc(Cl)s1)c1ccccc1F to have a lower LogP value.,N#C[C@H](NS(=O)(=O)c1ccc(Cl)s1)c1ccccc1F,3.083780000000001
109964,Please modify the molecule COc1cc(I)c(Cl)cc1C(=O)NCCC[C@H]1CCC[C@@H]1O to decrease its LogP value.,COc1cc(I)c(Cl)cc1C(=O)NCCC[C@H]1CCC[C@@H]1O,3.6242000000000023
62659,Optimize the molecule COCCC1(C(=O)N[C@@H](CO)c2ccco2)CCC1 to have a higher LogP value.,COCCC1(C(=O)N[C@@H](CO)c2ccco2)CCC1,1.636
42580,Modify the molecule Cc1sc2nc(CSc3ccc(C(C)C)cc3)[nH]c(=O)c2c1C to have a lower LogP value.,Cc1sc2nc(CSc3ccc(C(C)C)cc3)[nH]c(=O)c2c1C,5.017140000000004
210261,Modify the molecule C[C@H](Br)[C@H](C)c1ccc(Cl)cc1 to have a lower LogP value.,C[C@H](Br)[C@H](C)c1ccc(Cl)cc1,4.226900000000003
132355,Optimize the molecule CCN1CCO[C@@H]([C@@H](CCc2ccsc2)[NH2+]C)C1 to have a higher LogP value.,CCN1CCO[C@@H]([C@@H](CCc2ccsc2)[NH2+]C)C1,0.9632000000000004
207344,Please optimize the molecule CO[C@H]1CCCC[C@H]1NC(=O)N[C@@H](C)c1cccc(-n2ccnc2)c1 to have a lower LogP value.,CO[C@H]1CCCC[C@H]1NC(=O)N[C@@H](C)c1cccc(-n2ccnc2)c1,3.190100000000002
236142,Modify the molecule CC[C@H]1COCCN1C(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)c(F)c1 to decrease its LogP value.,CC[C@H]1COCCN1C(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)c(F)c1,2.1106000000000003
245432,Optimize the molecule COc1ccc(CNC(=O)c2cn(C)nc2OC)cc1 to have a lower LogP value.,COc1ccc(CNC(=O)c2cn(C)nc2OC)cc1,1.3673
207993,Please optimize the molecule CCOC(=O)C1=C(C)Nc2nc(SCc3ccccc3Cl)nn2[C@@H]1c1cccc(O)c1 to have a lower LogP value.,CCOC(=O)C1=C(C)Nc2nc(SCc3ccccc3Cl)nn2[C@@H]1c1cccc(O)c1,4.781400000000004
125598,Modify the molecule CN(C)C(=O)c1cc2ncc(C(=O)N3CCCC3)cc2n1C to have a lower LogP value.,CN(C)C(=O)c1cc2ncc(C(=O)N3CCCC3)cc2n1C,1.5110999999999999
216860,Please optimize the molecule C[C@H](NC(=O)Nc1ccccc1SCCC(N)=O)c1ccncc1 to have a higher LogP value.,C[C@H](NC(=O)Nc1ccccc1SCCC(N)=O)c1ccncc1,2.931800000000001
182514,Please optimize the molecule COCCCNC(=O)CSc1nc2ccccc2c2nc3ccccc3n12 to have a higher LogP value.,COCCCNC(=O)CSc1nc2ccccc2c2nc3ccccc3n12,3.2805000000000017
249169,Modify the molecule CCc1ccc(CC(CO)(CO)c2ccccc2Cl)cc1 to increase its LogP value.,CCc1ccc(CC(CO)(CO)c2ccccc2Cl)cc1,3.3675000000000015
216660,Modify the molecule COc1cc(F)cc(NC(=O)NCc2ncn(C)n2)c1 to decrease its LogP value.,COc1cc(F)cc(NC(=O)NCc2ncn(C)n2)c1,1.2844999999999998
159750,Modify the molecule CC[C@@H]1Oc2ccccc2N(CC(=O)Nc2ccccc2OC)C1=O to decrease its LogP value.,CC[C@@H]1Oc2ccccc2N(CC(=O)Nc2ccccc2OC)C1=O,2.837900000000001
88394,Please optimize the molecule C[C@@H]1CCC[NH+](CC(=O)Nc2nc(-c3ccc(F)cc3)cs2)C1 to have a lower LogP value.,C[C@@H]1CCC[NH+](CC(=O)Nc2nc(-c3ccc(F)cc3)cs2)C1,2.2024999999999997
8475,Please optimize the molecule Nc1ccc(Cl)cc1SCCC(=O)NC1CC1 to have a lower LogP value.,Nc1ccc(Cl)cc1SCCC(=O)NC1CC1,2.6830000000000007
88540,Optimize the molecule COc1cc(C)c(N)cc1S(=O)(=O)N[C@@H]1CC[C@H](C)[C@@H]1C to have a lower LogP value.,COc1cc(C)c(N)cc1S(=O)(=O)N[C@@H]1CC[C@H](C)[C@@H]1C,2.2987200000000003
232275,Optimize the molecule Cc1nn(-c2ncccn2)c2c1[C@@H](c1cccc(OCC(C)C)c1)SCC(O)=N2 to have a lower LogP value.,Cc1nn(-c2ncccn2)c2c1[C@@H](c1cccc(OCC(C)C)c1)SCC(O)=N2,4.429720000000003
230522,Please optimize the molecule C[C@@H](O)[C@@H](NC(=O)CCOc1ccc(Br)cc1)C(=O)[O-] to have a higher LogP value.,C[C@@H](O)[C@@H](NC(=O)CCOc1ccc(Br)cc1)C(=O)[O-],-0.16650000000000076
137687,Please optimize the molecule O=C([O-])Cn1nnnc1Sc1ncnc2c1CCCC2 to have a higher LogP value.,O=C([O-])Cn1nnnc1Sc1ncnc2c1CCCC2,-0.7570000000000008
125411,Optimize the molecule O=C(NCc1ncccc1F)N[C@H]1CCCC[C@H]1OC1CCCC1 to have a higher LogP value.,O=C(NCc1ncccc1F)N[C@H]1CCCC[C@H]1OC1CCCC1,3.290300000000002
157405,Modify the molecule COc1cc(C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)ccc1OC(C)C to have a higher LogP value.,COc1cc(C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)ccc1OC(C)C,3.747900000000003
2648,Modify the molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl to have a lower LogP value.,Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl,4.614240000000003
108390,Modify the molecule COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1 to decrease its LogP value.,COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1,2.804400000000001
86851,Please optimize the molecule COC[C@H](Nc1ncnc2ncccc12)c1ccc(F)c(F)c1 to have a higher LogP value.,COC[C@H](Nc1ncnc2ncccc12)c1ccc(F)c(F)c1,3.1026000000000016
111651,Please optimize the molecule CCOc1ccccc1C(=O)N1CCN([C@@H](C)C(=O)N2CCCC2)CC1 to have a higher LogP value.,CCOc1ccccc1C(=O)N1CCN([C@@H](C)C(=O)N2CCCC2)CC1,1.8539999999999999
194243,Optimize the molecule Cc1ccc(F)c(NC(=O)[C@H](C)N2C(=O)c3cc(Cl)c(Cl)cc3C2=O)c1 to have a lower LogP value.,Cc1ccc(F)c(NC(=O)[C@H](C)N2C(=O)c3cc(Cl)c(Cl)cc3C2=O)c1,4.064120000000003
129114,Modify the molecule NN[C@@H]1CS(=O)(=O)C[C@H]1O to decrease its LogP value.,NN[C@@H]1CS(=O)(=O)C[C@H]1O,-2.392399999999999
177748,Modify the molecule C[C@@H]1CCCC[NH+]1CCCNC(=O)c1cccc(-c2cc(N3CCCC3)ncn2)c1 to increase its LogP value.,C[C@@H]1CCCC[NH+]1CCCNC(=O)c1cccc(-c2cc(N3CCCC3)ncn2)c1,2.3209999999999997
16572,Modify the molecule CC[C@H]1SC(=S)N(CC(=O)Nc2cc(C)ccc2C)C1=O to increase its LogP value.,CC[C@H]1SC(=S)N(CC(=O)Nc2cc(C)ccc2C)C1=O,2.880840000000001
69910,Optimize the molecule CC(C)C[NH+]1CCCC[C@H]1C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1 to have a higher LogP value.,CC(C)C[NH+]1CCCC[C@H]1C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1,2.0006999999999997
133782,Modify the molecule Cc1cc(S(=O)(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)sc1C to have a lower LogP value.,Cc1cc(S(=O)(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)sc1C,3.169340000000002
22142,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H]1CCCCN1S(=O)(=O)c1cccc(S(N)(=O)=O)c1 to increase its LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H]1CCCCN1S(=O)(=O)c1cccc(S(N)(=O)=O)c1,2.276700000000001
151607,Optimize the molecule Cc1nc(C)c(C(=O)NC[C@H](O)c2c(F)cccc2F)s1 to have a higher LogP value.,Cc1nc(C)c(C(=O)NC[C@H](O)c2c(F)cccc2F)s1,2.5015400000000003
195145,Modify the molecule O=C(Nc1ccc(O)c(C(=O)[O-])c1)c1ccc(Br)o1 to increase its LogP value.,O=C(Nc1ccc(O)c(C(=O)[O-])c1)c1ccc(Br)o1,1.3635
241115,Optimize the molecule O=S(=O)(Nc1cc(F)ccc1F)c1ccccc1Br to have a lower LogP value.,O=S(=O)(Nc1cc(F)ccc1F)c1ccccc1Br,3.528100000000001
47762,Modify the molecule Oc1ccc([C@H]2Nc3c(F)cccc3[C@H]3C=CC[C@H]32)cc1 to decrease its LogP value.,Oc1ccc([C@H]2Nc3c(F)cccc3[C@H]3C=CC[C@H]32)cc1,4.357800000000003
127744,Optimize the molecule Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)Nc1ccc(OC(C)C)c(Cl)c1 to have a lower LogP value.,Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)Nc1ccc(OC(C)C)c(Cl)c1,4.836140000000004
98719,Please optimize the molecule CCSCC[C@H](C)NC(=O)C(=O)Nc1ccc2c(c1)oc(=O)n2C to have a lower LogP value.,CCSCC[C@H](C)NC(=O)C(=O)Nc1ccc2c(c1)oc(=O)n2C,1.7178999999999993
205566,Optimize the molecule CCCN(CCO)C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] to have a lower LogP value.,CCCN(CCO)C[C@@H]1CCC(C)(C)[C@@H]1[NH3+],0.7374000000000007
18515,Modify the molecule CCOC(=O)[C@]1(N)CC[C@@H](Sc2nnc(N(C)C)s2)C1 to decrease its LogP value.,CCOC(=O)[C@]1(N)CC[C@@H](Sc2nnc(N(C)C)s2)C1,1.5092999999999992
245019,Modify the molecule O=C(Nc1nc(-c2cccc(F)c2)cs1)c1csc(-c2nc[nH]n2)n1 to increase its LogP value.,O=C(Nc1nc(-c2cccc(F)c2)cs1)c1csc(-c2nc[nH]n2)n1,3.443100000000001
140921,Modify the molecule COC(=O)CSc1nnc(-c2ccccc2)n1-c1ccccc1C to have a higher LogP value.,COC(=O)CSc1nnc(-c2ccccc2)n1-c1ccccc1C,3.5078200000000024
221633,Optimize the molecule CN(Cc1ccc2c(c1)OCO2)S(=O)(=O)c1ncn(C)c1Cl to have a higher LogP value.,CN(Cc1ccc2c(c1)OCO2)S(=O)(=O)c1ncn(C)c1Cl,1.6228999999999998
108517,Modify the molecule CN(C[C@@H](O)C1CC1)C(=O)c1c(O)cc(F)cc1F to have a higher LogP value.,CN(C[C@@H](O)C1CC1)C(=O)c1c(O)cc(F)cc1F,1.5133
33870,Optimize the molecule Cn1c(=O)c2c(nc(N/N=C/c3ccccc3O)n2CCO)n(C)c1=O to have a higher LogP value.,Cn1c(=O)c2c(nc(N/N=C/c3ccccc3O)n2CCO)n(C)c1=O,-0.4224000000000001
27962,Optimize the molecule C[C@H](NC(=O)C[NH+]1CCCC1)c1ccccc1Cl to have a lower LogP value.,C[C@H](NC(=O)C[NH+]1CCCC1)c1ccccc1Cl,1.1959000000000006
134541,Modify the molecule COc1ccc(NC(=O)N2C[C@@H](C)C[C@H](C)C2)c(OC)c1OC to have a higher LogP value.,COc1ccc(NC(=O)N2C[C@@H](C)C[C@H](C)C2)c(OC)c1OC,3.2222000000000017
134033,Modify the molecule CN(C(=O)NC[C@H]1COc2ccccc2O1)[C@@H]1CCS(=O)(=O)C1 to increase its LogP value.,CN(C(=O)NC[C@H]1COc2ccccc2O1)[C@@H]1CCS(=O)(=O)C1,0.6548999999999998
71164,Please optimize the molecule CCNC(=O)[C@@H]1CCC[NH+](Cn2nc(-c3ccc(OC)cc3)n(C)c2=S)C1 to have a higher LogP value.,CCNC(=O)[C@@H]1CCC[NH+](Cn2nc(-c3ccc(OC)cc3)n(C)c2=S)C1,1.015190000000001
35413,Modify the molecule Cn1ccnc1[C@H](O)C1CC[NH+](C[C@H]2CC=CCC2)CC1 to have a higher LogP value.,Cn1ccnc1[C@H](O)C1CC[NH+](C[C@H]2CC=CCC2)CC1,1.1046999999999993
230139,Please optimize the molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)NCCO to have a lower LogP value.,Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)NCCO,1.3397399999999997
243228,Optimize the molecule CC[C@@H](C)N1C(=O)[C@H]2[C@@H](C1=O)[C@@H](C)N[C@@]21C(=O)Nc2ccc(Cl)cc21 to have a lower LogP value.,CC[C@@H](C)N1C(=O)[C@H]2[C@@H](C1=O)[C@@H](C)N[C@@]21C(=O)Nc2ccc(Cl)cc21,1.8787999999999996
111281,Optimize the molecule COC(=O)/C=c1/sc2n(c1=O)C[NH+]([C@H]1CCC[C@@H](C)[C@H]1C)CN=2 to have a higher LogP value.,COC(=O)/C=c1/sc2n(c1=O)C[NH+]([C@H]1CCC[C@@H](C)[C@H]1C)CN=2,-0.8788999999999976
207153,Optimize the molecule Cc1ccc(NC(=O)N2CCc3cn(C)c4cccc(c34)C2)cc1F to have a higher LogP value.,Cc1ccc(NC(=O)N2CCc3cn(C)c4cccc(c34)C2)cc1F,4.216020000000003
205242,Modify the molecule CCN1C[C@@H](C(=O)[O-])CC1=O to decrease its LogP value.,CCN1C[C@@H](C(=O)[O-])CC1=O,-1.395299999999999
179557,Modify the molecule O=C(c1c[nH]c2ccccc12)[C@H](NC[C@@H]1CCCO1)c1ccccc1 to increase its LogP value.,O=C(c1c[nH]c2ccccc12)[C@H](NC[C@@H]1CCCO1)c1ccccc1,3.8605000000000027
136144,Optimize the molecule Cc1nc([C@H](Cc2ccsc2)NC(=O)C[C@@H]2C(=O)NCC[NH+]2C)sc1C to have a higher LogP value.,Cc1nc([C@H](Cc2ccsc2)NC(=O)C[C@@H]2C(=O)NCC[NH+]2C)sc1C,0.624640000000001
223904,Please optimize the molecule CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccc(CC)cc5)no4)cnc32)cc1 to have a lower LogP value.,CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccc(CC)cc5)no4)cnc32)cc1,3.036600000000001
13850,Modify the molecule COc1ccc2c(c1)CC[C@H]1C2=NN(C(C)=O)[C@H]1c1ccccc1 to decrease its LogP value.,COc1ccc2c(c1)CC[C@H]1C2=NN(C(C)=O)[C@H]1c1ccccc1,3.565100000000003
106744,Modify the molecule C[C@H](C(=O)NN)[C@H](C)n1cc(C(F)(F)F)cn1 to have a lower LogP value.,C[C@H](C(=O)NN)[C@H](C)n1cc(C(F)(F)F)cn1,1.0889
216552,Please optimize the molecule CC(=O)c1ccccc1OCCOn1nnc2ccccc21 to have a higher LogP value.,CC(=O)c1ccccc1OCCOn1nnc2ccccc21,2.1414999999999997
2452,Please optimize the molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F to have a lower LogP value.,CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F,1.6388999999999996
202792,Please modify the molecule CCCn1c([C@@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21 to increase its LogP value.,CCCn1c([C@@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21,3.9624000000000033
151201,Modify the molecule CCNC(=O)[C@@H](C)[NH+]1CCC(n2nccc2NC(=O)c2ccccc2C)CC1 to have a higher LogP value.,CCNC(=O)[C@@H](C)[NH+]1CCC(n2nccc2NC(=O)c2ccccc2C)CC1,1.1882200000000007
162013,Modify the molecule Cn1cc(C(=O)N2CCC[C@@H](Cn3ccnn3)C2)c(-c2ccccc2)n1 to have a higher LogP value.,Cn1cc(C(=O)N2CCC[C@@H](Cn3ccnn3)C2)c(-c2ccccc2)n1,2.231
196566,Please modify the molecule O=C([O-])c1ccccc1N1CC[NH+]2CCCC[C@@H]2C1 to decrease its LogP value.,O=C([O-])c1ccccc1N1CC[NH+]2CCCC[C@@H]2C1,-0.6924999999999988
240835,Please optimize the molecule CC1CC[NH+](CCNS(=O)(=O)c2ccccc2C(F)(F)F)CC1 to have a higher LogP value.,CC1CC[NH+](CCNS(=O)(=O)c2ccccc2C(F)(F)F)CC1,1.2985000000000002
18790,Please modify the molecule O=C(NN1CCCCC1)[C@H]1C[C@@H]1c1ccc(F)cc1F to increase its LogP value.,O=C(NN1CCCCC1)[C@H]1C[C@@H]1c1ccc(F)cc1F,2.585400000000001
3277,Please modify the molecule CC[C@@H](C[NH3+])c1nc2cccc(C)c2o1 to increase its LogP value.,CC[C@@H](C[NH3+])c1nc2cccc(C)c2o1,1.8717199999999996
109397,Modify the molecule CC[C@H]1CCc2sc(C(=O)NC3COC3)cc2C1 to have a higher LogP value.,CC[C@H]1CCc2sc(C(=O)NC3COC3)cc2C1,2.3916000000000004
39786,Modify the molecule CC(C)c1csc(/C(C#N)=C\c2csc(-c3ccc(F)cc3)n2)n1 to decrease its LogP value.,CC(C)c1csc(/C(C#N)=C\c2csc(-c3ccc(F)cc3)n2)n1,5.593280000000004
203080,Modify the molecule CC(C)[NH+](CCCO)C[C@@H]1CN(C)CCO1 to increase its LogP value.,CC(C)[NH+](CCCO)C[C@@H]1CN(C)CCO1,-1.0072999999999965
183706,Please modify the molecule CCC[C@H](C)CC(=O)Nc1cnn(CC(C)C)c1 to decrease its LogP value.,CCC[C@H](C)CC(=O)Nc1cnn(CC(C)C)c1,3.3039000000000023
108758,Optimize the molecule O=S(=O)(c1ccccc1)[C@@H](c1ccccc1)c1ccccn1 to have a higher LogP value.,O=S(=O)(c1ccccc1)[C@@H](c1ccccc1)c1ccccn1,3.6449000000000025
90534,Please optimize the molecule C[C@H]1CCC[C@H](CC(=O)Nc2ccc(C(=O)NC3CCOCC3)cc2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](CC(=O)Nc2ccc(C(=O)NC3CCOCC3)cc2)C1,3.750300000000003
200952,Modify the molecule CC(=O)O/N=c1\oc2cc3c(cc2c2c1CCC2)CCC(C)(C)O3 to increase its LogP value.,CC(=O)O/N=c1\oc2cc3c(cc2c2c1CCC2)CCC(C)(C)O3,3.403900000000002
148232,Optimize the molecule CCS[C@H]1CCCC[C@@H]1NC(=O)N1CCC[C@H]([NH+](C)C)C1 to have a lower LogP value.,CCS[C@H]1CCCC[C@@H]1NC(=O)N1CCC[C@H]([NH+](C)C)C1,1.369200000000001
170630,Please modify the molecule CCOC(=O)c1c(NC(=O)Cn2ccc(=O)c3cccc(F)c32)sc2c1CCCC2 to increase its LogP value.,CCOC(=O)c1c(NC(=O)Cn2ccc(=O)c3cccc(F)c32)sc2c1CCCC2,3.8963000000000036
19580,Modify the molecule CCC[C@H](CC(=O)OC)NC(=O)c1cnc2ccccn12 to have a higher LogP value.,CCC[C@H](CC(=O)OC)NC(=O)c1cnc2ccccn12,1.7959
153650,Please optimize the molecule Cc1nc(C)n([C@@H](C)CC(=O)Nc2ccc3c(c2)OC(C)(C)O3)n1 to have a lower LogP value.,Cc1nc(C)n([C@@H](C)CC(=O)Nc2ccc3c(c2)OC(C)(C)O3)n1,2.992040000000001
47573,Please optimize the molecule O=c1[nH]c(NCc2ccccc2)nc2nccc(-c3ccccc3)c12 to have a lower LogP value.,O=c1[nH]c(NCc2ccccc2)nc2nccc(-c3ccccc3)c12,3.5972000000000026
63907,Optimize the molecule O=C(NC1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)c1ccncc1 to have a lower LogP value.,O=C(NC1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)c1ccncc1,2.5975
212684,Please modify the molecule CN(CC(F)F)C(=O)C(=O)Nc1ccc(NC(=O)c2ccccc2)nc1 to increase its LogP value.,CN(CC(F)F)C(=O)C(=O)Nc1ccc(NC(=O)c2ccccc2)nc1,1.9958999999999998
4153,Optimize the molecule Cc1noc(C)c1CN(C)C(=O)c1cccc(C[S@](C)=O)c1 to have a higher LogP value.,Cc1noc(C)c1CN(C)C(=O)c1cccc(C[S@](C)=O)c1,2.44214
177746,Optimize the molecule C[C@@H](NC(=O)N1CCN(C(=O)N2CCOCC2)CC1)c1ccccc1 to have a higher LogP value.,C[C@@H](NC(=O)N1CCN(C(=O)N2CCOCC2)CC1)c1ccccc1,1.5270000000000004
234861,Optimize the molecule O=C(c1ccc(-c2ccccc2F)o1)N1CCN(c2ccccc2O)CC1 to have a lower LogP value.,O=C(c1ccc(-c2ccccc2F)o1)N1CCN(c2ccccc2O)CC1,3.753700000000002
226379,Modify the molecule C=CCNC(=O)NC(=O)C[NH+]1CCC(C(=O)N2CCCCCC2)CC1 to decrease its LogP value.,C=CCNC(=O)NC(=O)C[NH+]1CCC(C(=O)N2CCCCCC2)CC1,-0.30429999999999735
18202,Optimize the molecule CCO[C@@H]1CCCN(C(=O)Nc2ccn(CCCOC)n2)C1 to have a higher LogP value.,CCO[C@@H]1CCCN(C(=O)Nc2ccn(CCCOC)n2)C1,1.9523999999999997
139928,Please optimize the molecule CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2cccc3c2CCCC3)c1 to have a higher LogP value.,CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2cccc3c2CCCC3)c1,4.207100000000003
249226,Please modify the molecule Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1,4.654920000000004
91359,Please optimize the molecule CCOCCN(C)C(=O)c1ccn(-c2cc(C)ccc2OC)n1 to have a higher LogP value.,CCOCCN(C)C(=O)c1ccn(-c2cc(C)ccc2OC)n1,2.2978200000000006
27949,Modify the molecule CCc1[nH+]ccn1Cc1noc(-c2cc(OC)c(OC)c(OC)c2)n1 to have a lower LogP value.,CCc1[nH+]ccn1Cc1noc(-c2cc(OC)c(OC)c(OC)c2)n1,1.9887
240762,Please optimize the molecule O=C(CSc1ccc(Cl)cc1)Nc1cccc(C(=O)Nc2ccc(C(=O)[O-])cc2)c1 to have a lower LogP value.,O=C(CSc1ccc(Cl)cc1)Nc1cccc(C(=O)Nc2ccc(C(=O)[O-])cc2)c1,3.686600000000001
104898,Please modify the molecule CN(CC(=O)N1CCCc2cc(S(=O)(=O)N(C)C)ccc21)c1ccccc1 to increase its LogP value.,CN(CC(=O)N1CCCc2cc(S(=O)(=O)N(C)C)ccc21)c1ccccc1,2.3525
38063,Please modify the molecule Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1,4.615720000000003
15737,Please modify the molecule Cc1nc(C(F)(F)F)nc(C2=CN=NC2)c1C to increase its LogP value.,Cc1nc(C(F)(F)F)nc(C2=CN=NC2)c1C,2.918940000000001
140881,Modify the molecule Cc1nn(-c2ccc3nnc(C)n3n2)c2c1[C@H](c1ccccc1OCC(C)C)CC(O)=N2 to increase its LogP value.,Cc1nn(-c2ccc3nnc(C)n3n2)c2c1[C@H](c1ccccc1OCC(C)C)CC(O)=N2,4.085240000000002
224298,Modify the molecule COc1ccc(/N=C/c2cccc(O)c2)cc1 to increase its LogP value.,COc1ccc(/N=C/c2cccc(O)c2)cc1,3.1514000000000015
111200,Please modify the molecule Cc1cc([C@H]([NH3+])C2CCCCCC2)sc1Br to decrease its LogP value.,Cc1cc([C@H]([NH3+])C2CCCCCC2)sc1Br,4.072420000000003
200391,Modify the molecule Cc1oc(C(=O)N(C)[C@H](C)c2ccccc2)cc1S(=O)(=O)N(C)C to decrease its LogP value.,Cc1oc(C(=O)N(C)[C@H](C)c2ccccc2)cc1S(=O)(=O)N(C)C,2.671520000000001
63223,Optimize the molecule Cc1ccsc1C(=O)OCC(=O)NCc1ccc(C(F)(F)F)cc1 to have a higher LogP value.,Cc1ccsc1C(=O)OCC(=O)NCc1ccc(C(F)(F)F)cc1,3.5485200000000017
78665,Optimize the molecule O=C(c1ccc(-n2cnnc2)cc1)N1CCN([C@@H]2CCC[C@H]2O)CC1 to have a higher LogP value.,O=C(c1ccc(-n2cnnc2)cc1)N1CCN([C@@H]2CCC[C@H]2O)CC1,0.9384999999999999
188840,Modify the molecule Cc1occc1-c1nnc(SCC(=O)c2ccc(C(C)C)cc2)o1 to have a higher LogP value.,Cc1occc1-c1nnc(SCC(=O)c2ccc(C(C)C)cc2)o1,4.736420000000003
118056,Optimize the molecule CC(=S)N(C)c1ccccc1 to have a higher LogP value.,CC(=S)N(C)c1ccccc1,2.4701000000000004
171069,Modify the molecule CC(=O)Nc1ccc(NC(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2)cc1 to decrease its LogP value.,CC(=O)Nc1ccc(NC(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2)cc1,3.9760000000000018
239705,Optimize the molecule Oc1cccc(-c2cccc(Cl)c2)c1 to have a higher LogP value.,Oc1cccc(-c2cccc(Cl)c2)c1,3.712600000000001
140122,Optimize the molecule Cc1n[nH]c(C)c1CCC(=O)N1CCO[C@](C)(C(N)=O)C1 to have a higher LogP value.,Cc1n[nH]c(C)c1CCC(=O)N1CCO[C@](C)(C(N)=O)C1,0.06194000000000044
133880,Please optimize the molecule [O-]c1c(F)cc(C[NH2+][C@@H]2CCC[C@@H](O)C2)cc1F to have a higher LogP value.,[O-]c1c(F)cc(C[NH2+][C@@H]2CCC[C@@H](O)C2)cc1F,0.40529999999999916
39346,Modify the molecule CNC(=O)[C@@H](NS(=O)(=O)c1cnn(C)c1)c1ccc(F)c(F)c1 to decrease its LogP value.,CNC(=O)[C@@H](NS(=O)(=O)c1cnn(C)c1)c1ccc(F)c(F)c1,0.4639
107642,Optimize the molecule O=C(NCC[C@@H]1C[C@H]2CC[C@@H]1C2)N1CCCC1 to have a higher LogP value.,O=C(NCC[C@@H]1C[C@H]2CC[C@@H]1C2)N1CCCC1,2.618100000000001
156399,Please optimize the molecule C[C@@H](O)[C@@H](C)Nc1cnn(C)c1 to have a lower LogP value.,C[C@@H](O)[C@@H](C)Nc1cnn(C)c1,0.6012999999999997
87904,Modify the molecule CN(CC(C)(C)C[NH3+])C(=O)c1ccc[nH]1 to decrease its LogP value.,CN(CC(C)(C)C[NH3+])C(=O)c1ccc[nH]1,0.35480000000000084
12617,Modify the molecule Cc1cc(OC[C@@H]2CCCO2)c([C@H](C)[NH3+])cc1F to increase its LogP value.,Cc1cc(OC[C@@H]2CCCO2)c([C@H](C)[NH3+])cc1F,1.9948199999999998
234275,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1CNCc1c(F)cccc1F to increase its LogP value.,Cc1nn(-c2ccccc2)c(C)c1CNCc1c(F)cccc1F,4.057140000000003
55866,Please optimize the molecule CCOC(=O)C1=C(C)N/C(=C\c2cccc(Cl)c2)C1=O to have a lower LogP value.,CCOC(=O)C1=C(C)N/C(=C\c2cccc(Cl)c2)C1=O,2.6903000000000006
159877,Please modify the molecule CCCC[NH+](CC)[C@H]1Cc2ccc(OC)cc2[C@@H]1O to increase its LogP value.,CCCC[NH+](CC)[C@H]1Cc2ccc(OC)cc2[C@@H]1O,1.3582
156744,Please modify the molecule COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1 to increase its LogP value.,COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1,2.1278999999999995
21860,Please optimize the molecule CC(C)n1cnnc1S[C@@H](C)c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,CC(C)n1cnnc1S[C@@H](C)c1ccc(Cl)c(Cl)c1,5.0191000000000034
88255,Modify the molecule Cc1n[nH]c(-n2cnnc2)c1NC(=O)c1ccccc1Cl to decrease its LogP value.,Cc1n[nH]c(-n2cnnc2)c1NC(=O)c1ccccc1Cl,2.2045199999999996
157059,Modify the molecule C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1 to have a higher LogP value.,C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1,3.0729000000000015
222856,Modify the molecule COc1ccc(CCCC(=O)N2CCc3nn(C)c(=O)cc3C2)cc1F to have a higher LogP value.,COc1ccc(CCCC(=O)N2CCc3nn(C)c(=O)cc3C2)cc1F,1.8356
244933,Modify the molecule N#Cc1ccc(NC(=O)N2CCNC(=O)C[C@H]2c2ccccc2)cc1 to have a lower LogP value.,N#Cc1ccc(NC(=O)N2CCNC(=O)C[C@H]2c2ccccc2)cc1,2.653380000000001
51465,Please modify the molecule COC(=O)C1=C(C)N=C2S[C@H](C)C(=O)N2[C@H]1c1ccc(C)cc1 to increase its LogP value.,COC(=O)C1=C(C)N=C2S[C@H](C)C(=O)N2[C@H]1c1ccc(C)cc1,2.8166200000000012
59674,Please modify the molecule Cc1ccc(-n2nnc(C(=O)N3CCC[NH+](C(C)C)CC3)c2C)cc1 to increase its LogP value.,Cc1ccc(-n2nnc(C(=O)N3CCC[NH+](C(C)C)CC3)c2C)cc1,1.0233400000000004
27061,Please modify the molecule CC(C)N1CCO[C@H](C(=O)CC2CCOCC2)C1 to decrease its LogP value.,CC(C)N1CCO[C@H](C(=O)CC2CCOCC2)C1,1.4813999999999996
131848,Optimize the molecule Cc1ccccc1NC(=O)C1CCN(S(=O)(=O)c2ccccc2)CC1 to have a higher LogP value.,Cc1ccccc1NC(=O)C1CCN(S(=O)(=O)c2ccccc2)CC1,3.0344200000000017
196937,Please optimize the molecule CCN1CC(=O)N(CCCCC(=O)NN)CC1=O to have a higher LogP value.,CCN1CC(=O)N(CCCCC(=O)NN)CC1=O,-1.1626999999999978
18840,Please optimize the molecule C[C@H]1CC[C@H](CCC(=O)Nc2c(F)cccc2F)O1 to have a higher LogP value.,C[C@H]1CC[C@H](CCC(=O)Nc2c(F)cccc2F)O1,3.2510000000000012
2681,Please optimize the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 to have a lower LogP value.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1,2.994600000000002
168925,Please modify the molecule COc1c(Cl)cc(Cl)cc1/C=C(\C#N)c1nn(CCO)c(N)c1C#N to decrease its LogP value.,COc1c(Cl)cc(Cl)cc1/C=C(\C#N)c1nn(CCO)c(N)c1C#N,2.708860000000001
70362,Optimize the molecule C#CCNCC(=O)N[C@@H](C)c1cnn(C)c1C to have a higher LogP value.,C#CCNCC(=O)N[C@@H](C)c1cnn(C)c1C,0.12851999999999952
145848,Please optimize the molecule CCOc1ccc(NC(=O)[C@@H]2Cc3ccccc3CN2C(C)=O)cc1OC to have a higher LogP value.,CCOc1ccc(NC(=O)[C@@H]2Cc3ccccc3CN2C(C)=O)cc1OC,3.0058000000000016
200857,Please modify the molecule OCCCn1c(SCc2ccccc2Cl)nnc1-c1cccnc1 to increase its LogP value.,OCCCn1c(SCc2ccccc2Cl)nnc1-c1cccnc1,3.6682000000000023
43342,Modify the molecule O=C(COC(=O)c1cc2ccccc2oc1=O)NC1CCCCC1 to have a higher LogP value.,O=C(COC(=O)c1cc2ccccc2oc1=O)NC1CCCCC1,2.3987000000000007
78338,Modify the molecule COc1ccccc1C[C@H](O)C(C)(C)[NH+]1CCCCCC1 to have a higher LogP value.,COc1ccccc1C[C@H](O)C(C)(C)[NH+]1CCCCCC1,1.8360999999999996
101204,Optimize the molecule N#CCCNS(=O)(=O)c1ccc(C(=O)NCC(F)(F)F)cc1 to have a higher LogP value.,N#CCCNS(=O)(=O)c1ccc(C(=O)NCC(F)(F)F)cc1,1.17068
22,Please optimize the molecule O=C(NCCNC(=O)N1C[C@H]2CC=CC[C@@H]2C1)c1cccnc1 to have a higher LogP value.,O=C(NCCNC(=O)N1C[C@H]2CC=CC[C@@H]2C1)c1cccnc1,1.4189999999999996
104611,Optimize the molecule CCOC[C@@H](O)CN1CCN(c2ccc(CC)cc2)CC1 to have a higher LogP value.,CCOC[C@@H](O)CN1CCN(c2ccc(CC)cc2)CC1,1.7683999999999997
221182,Modify the molecule C#CCOc1ccc(C[NH2+][C@@H](C)c2ccccc2)cc1 to decrease its LogP value.,C#CCOc1ccc(C[NH2+][C@@H](C)c2ccccc2)cc1,2.523200000000001
236189,Modify the molecule CCC(=O)N[C@@H](CCSC)C(=O)Nc1ccc(C)cc1 to decrease its LogP value.,CCC(=O)N[C@@H](CCSC)C(=O)Nc1ccc(C)cc1,2.5814200000000005
58046,Please modify the molecule Cc1cc(C)c(S(=O)(=O)Nc2ccc(N3CC[NH2+]CC3)c(C(=O)N3CCOCC3)c2)c(C)c1 to decrease its LogP value.,Cc1cc(C)c(S(=O)(=O)Nc2ccc(N3CC[NH2+]CC3)c(C(=O)N3CCOCC3)c2)c(C)c1,1.2684600000000021
156472,Please optimize the molecule CC(C)[C@@H](NC(=O)c1cnsn1)c1cccs1 to have a lower LogP value.,CC(C)[C@@H](NC(=O)c1cnsn1)c1cccs1,2.726700000000001
110571,Please optimize the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(C(=O)Nc2ccc(-n3cnc4ccccc43)cc2)cc1 to have a higher LogP value.,CC[C@@H](C)NS(=O)(=O)c1ccc(C(=O)Nc2ccc(-n3cnc4ccccc43)cc2)cc1,4.354600000000003
29131,Please optimize the molecule N/C(NCCc1csc(-c2ccccc2)n1)=[NH+]\C[C@@H]1CCCO1 to have a higher LogP value.,N/C(NCCc1csc(-c2ccccc2)n1)=[NH+]\C[C@@H]1CCCO1,0.5165
232917,Modify the molecule CC(C)[C@@H](CNC(=O)N1CCN(c2nccs2)CC1)[NH+]1CCCCCC1 to have a lower LogP value.,CC(C)[C@@H](CNC(=O)N1CCN(c2nccs2)CC1)[NH+]1CCCCCC1,1.4582000000000013
229531,Please modify the molecule Cc1noc2nc(-c3cnn(C)c3)cc(C(=O)NCCCn3nccc3C3CC3)c12 to increase its LogP value.,Cc1noc2nc(-c3cnn(C)c3)cc(C(=O)NCCCn3nccc3C3CC3)c12,2.8257200000000013
187443,Please modify the molecule CCCOc1cccc(/C=c2\s/c(=C\C(=O)c3ccco3)[nH]c2=O)c1 to increase its LogP value.,CCCOc1cccc(/C=c2\s/c(=C\C(=O)c3ccco3)[nH]c2=O)c1,2.3104000000000005
1810,Please optimize the molecule C[C@@H](N[C@H]1CCc2c(Cl)cc(Cl)cc21)c1nnc2ccccn12 to have a higher LogP value.,C[C@@H](N[C@H]1CCc2c(Cl)cc(Cl)cc21)c1nnc2ccccn12,4.374200000000004
125311,Modify the molecule Cc1cc(S(=O)(=O)N[C@H](c2nccs2)C2CC2)c(F)cc1F to decrease its LogP value.,Cc1cc(S(=O)(=O)N[C@H](c2nccs2)C2CC2)c(F)cc1F,3.159320000000002
132058,Please optimize the molecule O=[N+]([O-])c1ccc(C(F)(F)F)nc1Cl to have a lower LogP value.,O=[N+]([O-])c1ccc(C(F)(F)F)nc1Cl,2.662000000000001
13524,Optimize the molecule COC(=O)c1ncccc1N[C@@H]1CCO[C@H]1c1ccc(Cl)cc1 to have a lower LogP value.,COC(=O)c1ncccc1N[C@@H]1CCO[C@H]1c1ccc(Cl)cc1,3.463700000000002
112989,Optimize the molecule COC(=O)CC(=O)c1cc(Cl)cc(Cl)c1 to have a higher LogP value.,COC(=O)CC(=O)c1cc(Cl)cc(Cl)c1,2.739200000000001
47409,Optimize the molecule CCc1nc([C@@H]2CCCN2Cc2ccc(C#N)cc2F)no1 to have a lower LogP value.,CCc1nc([C@@H]2CCCN2Cc2ccc(C#N)cc2F)no1,2.9798800000000014
241398,Modify the molecule CCOc1ccc(C2=N[C@@H](c3cccc(F)c3)[NH2+][C@H](c3cccc(OCC)c3O)C2)cc1 to increase its LogP value.,CCOc1ccc(C2=N[C@@H](c3cccc(F)c3)[NH2+][C@H](c3cccc(OCC)c3O)C2)cc1,4.525000000000004
23222,Modify the molecule C[NH+](C)[C@H]1CCN(c2nc3ccc(Cl)cc3s2)C[C@H]1CCCO to decrease its LogP value.,C[NH+](C)[C@H]1CCN(c2nc3ccc(Cl)cc3s2)C[C@H]1CCCO,2.0616000000000008
245866,Modify the molecule O=C(CCn1c(=O)oc2ccccc21)NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O to have a lower LogP value.,O=C(CCn1c(=O)oc2ccccc21)NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O,2.5114
32643,Modify the molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)c1oc(C)nc1C to have a higher LogP value.,CCN(Cc1ccc(OC)c(OC)c1)C(=O)c1oc(C)nc1C,2.9709400000000015
216665,Please modify the molecule CCOc1cc2[nH]c(=S)n([C@@H](C)CC)c(=O)c2cc1OCC to decrease its LogP value.,CCOc1cc2[nH]c(=S)n([C@@H](C)CC)c(=O)c2cc1OCC,3.8274900000000027
160588,Please modify the molecule O=C(CCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)NC1CCCCCC1 to decrease its LogP value.,O=C(CCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)NC1CCCCCC1,2.1666999999999996
15165,Modify the molecule Cc1ccc(C[NH2+]CCCN2CCCCCC2=O)s1 to decrease its LogP value.,Cc1ccc(C[NH2+]CCCN2CCCCCC2=O)s1,1.9126199999999998
230238,Modify the molecule CN(C)c1cnn(CCC[NH+]2CCN(c3cccc(Cl)c3)CC2)c(=O)c1 to increase its LogP value.,CN(C)c1cnn(CCC[NH+]2CCN(c3cccc(Cl)c3)CC2)c(=O)c1,0.7579000000000009
204346,Please modify the molecule CCOC(=O)C1(C(=O)Nc2cnc(-c3ccccc3)s2)CC1 to decrease its LogP value.,CCOC(=O)C1(C(=O)Nc2cnc(-c3ccccc3)s2)CC1,3.0919000000000016
191649,Optimize the molecule CCOC(=O)c1cc(-c2cccs2)nc2c1c(C)nn2-c1cccc(C)c1 to have a higher LogP value.,CCOC(=O)c1cc(-c2cccs2)nc2c1c(C)nn2-c1cccc(C)c1,4.942540000000005
134524,Please modify the molecule NC(=O)C1([NH2+]Cc2nnc(Cc3ccccc3)o2)CCCCC1 to decrease its LogP value.,NC(=O)C1([NH2+]Cc2nnc(Cc3ccccc3)o2)CCCCC1,0.9120000000000001
66125,Please optimize the molecule CC[C@@]1(c2ccc(NC(=O)c3nc(-c4ccco4)sc3C)cc2)CCC(=O)NC1=O to have a higher LogP value.,CC[C@@]1(c2ccc(NC(=O)c3nc(-c4ccco4)sc3C)cc2)CCC(=O)NC1=O,4.048220000000002
152959,Modify the molecule COc1cccc(Nc2ncnc(-n3cnc4ccccc43)c2[N+](=O)[O-])c1 to decrease its LogP value.,COc1cccc(Nc2ncnc(-n3cnc4ccccc43)c2[N+](=O)[O-])c1,3.475900000000002
194866,Modify the molecule Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)c2n1 to increase its LogP value.,Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)c2n1,-1.3266000000000007
190364,Please optimize the molecule CCS[C@H]1CCCC[C@H]1NC(=O)N[C@@H]1CCN(C(C)C)C1=O to have a lower LogP value.,CCS[C@H]1CCCC[C@H]1NC(=O)N[C@@H]1CCN(C(C)C)C1=O,2.3592000000000004
25970,Modify the molecule O=C(CCc1ccsc1)N1Cc2ccccc2[C@H](c2ccccc2)C1 to have a higher LogP value.,O=C(CCc1ccsc1)N1Cc2ccccc2[C@H](c2ccccc2)C1,4.855000000000005
207146,Modify the molecule C/C(CC(=O)Nc1ccc(F)cc1F)=N\NC(=O)c1ccc(O)cc1 to decrease its LogP value.,C/C(CC(=O)Nc1ccc(F)cc1F)=N\NC(=O)c1ccc(O)cc1,2.804900000000001
11694,Optimize the molecule COC(=O)c1cc(C[NH+]2[C@@H](C)CC[C@@H]2C)c[nH]1 to have a higher LogP value.,COC(=O)c1cc(C[NH+]2[C@@H](C)CC[C@@H]2C)c[nH]1,0.7569999999999999
146946,Optimize the molecule C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1 to have a higher LogP value.,C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1,4.473300000000003
233083,Modify the molecule Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12 to have a higher LogP value.,Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12,3.0211200000000016
138275,Please modify the molecule CC(=O)NC(=S)Nc1ccc(C(=O)NC(C)(C)C)cc1 to increase its LogP value.,CC(=O)NC(=S)Nc1ccc(C(=O)NC(C)(C)C)cc1,2.0478
67658,Optimize the molecule C[NH+](Cc1ccc(C(=O)NC2CC2)cc1)Cc1cc2c(cc1Br)OCCO2 to have a lower LogP value.,C[NH+](Cc1ccc(C(=O)NC2CC2)cc1)Cc1cc2c(cc1Br)OCCO2,2.327400000000001
57506,Optimize the molecule C[C@H]1CCC[C@H](OCc2cccc(NC(=O)[C@H](C)[NH+](C)C)c2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](OCc2cccc(NC(=O)[C@H](C)[NH+](C)C)c2)C1,2.2534
88667,Please optimize the molecule Cc1cccc(N/C([O-])=C(\C#N)C(=O)Cn2nc3n(c2=O)CCCCC3)c1 to have a lower LogP value.,Cc1cccc(N/C([O-])=C(\C#N)C(=O)Cn2nc3n(c2=O)CCCCC3)c1,0.8562999999999992
22960,Please modify the molecule CC(C)C[NH+]1CC[C@H](N2CCOCC2)C[C@H]1C to increase its LogP value.,CC(C)C[NH+]1CC[C@H](N2CCOCC2)C[C@H]1C,0.4104000000000012
61439,Please optimize the molecule CC(C)(O)CC[NH+]1CCN(c2ccc(F)cc2)CC1 to have a lower LogP value.,CC(C)(O)CC[NH+]1CCN(c2ccc(F)cc2)CC1,0.6916000000000002
46267,Please modify the molecule C[NH+](CC(=O)NC1(C#N)CCCCCC1)[C@@H]1CCCc2ccccc21 to increase its LogP value.,C[NH+](CC(=O)NC1(C#N)CCCCCC1)[C@@H]1CCCc2ccccc21,2.3114799999999995
110439,Modify the molecule CC[C@H]1CCCN(C(=O)NCc2ccccc2C)C1 to increase its LogP value.,CC[C@H]1CCCN(C(=O)NCc2ccccc2C)C1,3.326620000000002
186566,Modify the molecule COc1ccc([C@@H]2CCCN2C(=O)Nc2ccc3oc(C4CC4)nc3c2)c(OC)c1 to have a higher LogP value.,COc1ccc([C@@H]2CCCN2C(=O)Nc2ccc3oc(C4CC4)nc3c2)c(OC)c1,5.091400000000005
214340,Optimize the molecule Fc1cc(CNc2ncnc3[nH]cnc23)ccc1Oc1cccnc1 to have a higher LogP value.,Fc1cc(CNc2ncnc3[nH]cnc23)ccc1Oc1cccnc1,3.291400000000001
89051,Please modify the molecule O=C(CC1=c2ccccc2=[NH+]C1)OCC(=O)N1CCc2ccccc21 to increase its LogP value.,O=C(CC1=c2ccccc2=[NH+]C1)OCC(=O)N1CCc2ccccc21,-0.926299999999997
5532,Optimize the molecule C[NH2+]Cc1ccc(OCc2c[nH+]cn2C)c(Cl)c1 to have a lower LogP value.,C[NH2+]Cc1ccc(OCc2c[nH+]cn2C)c(Cl)c1,0.7647999999999995
210001,Modify the molecule NC(=O)c1ccc(NCc2cc(Cl)cs2)cc1Cl to have a higher LogP value.,NC(=O)c1ccc(NCc2cc(Cl)cs2)cc1Cl,3.765900000000001
10717,Optimize the molecule COc1ccccc1NC(=O)c1sc2ncn(C[C@@H](O)CO)c(=O)c2c1C to have a lower LogP value.,COc1ccccc1NC(=O)c1sc2ncn(C[C@@H](O)CO)c(=O)c2c1C,1.3805199999999997
16263,Optimize the molecule CN(C[C@H]1CCCCO1)C(=O)c1cc2ccccc2c(=O)[nH]1 to have a lower LogP value.,CN(C[C@H]1CCCCO1)C(=O)c1cc2ccccc2c(=O)[nH]1,2.1692
244247,Modify the molecule CC(C)n1nc(C[NH2+]CCCO)c(-c2ccccc2)n1 to decrease its LogP value.,CC(C)n1nc(C[NH2+]CCCO)c(-c2ccccc2)n1,0.9717999999999996
16580,Modify the molecule CCC(=O)N(C)c1ccccc1C(=O)Nc1ccc2c(c1)OCCO2 to increase its LogP value.,CCC(=O)N(C)c1ccccc1C(=O)Nc1ccc2c(c1)OCCO2,3.0829000000000013
119786,Modify the molecule CN(C)c1ccc(/C=N/N2C(=O)[C@@H]3[C@@H](C2=O)[C@H]2C=C[C@@H]3C23CC3)cc1Br to have a higher LogP value.,CN(C)c1ccc(/C=N/N2C(=O)[C@@H]3[C@@H](C2=O)[C@H]2C=C[C@@H]3C23CC3)cc1Br,3.0462000000000016
198554,Modify the molecule CC[C@@](C)([NH2+]CC(=O)N[C@@H](C)C(C)C)C(=O)[O-] to have a higher LogP value.,CC[C@@](C)([NH2+]CC(=O)N[C@@H](C)C(C)C)C(=O)[O-],-1.3708999999999976
151999,Please optimize the molecule COc1ncccc1C(=O)OCc1nnc(-c2ccccc2)n1C to have a higher LogP value.,COc1ncccc1C(=O)OCc1nnc(-c2ccccc2)n1C,2.2427
190438,Please modify the molecule CC(=O)Nc1cc(NC(=O)C(C)(C)F)ccc1F to increase its LogP value.,CC(=O)Nc1cc(NC(=O)C(C)(C)F)ccc1F,2.4707
175353,Modify the molecule C=C(C)[C@@H]1CC=C(CN2C[C@H](NC(=O)c3cc(C)nc4ccccc34)C[C@H]2C(=O)OC)CC1 to increase its LogP value.,C=C(C)[C@@H]1CC=C(CN2C[C@H](NC(=O)c3cc(C)nc4ccccc34)C[C@H]2C(=O)OC)CC1,4.191520000000003
77561,Modify the molecule CN(Cc1nc2c(F)cccc2[nH]1)[C@@H]1CCSC1 to increase its LogP value.,CN(Cc1nc2c(F)cccc2[nH]1)[C@@H]1CCSC1,2.6393000000000004
117432,Modify the molecule C=CC[C@@H]1CC=C[C@@H](c2ccccc2)N1C(=O)CCc1c(C)nn(C)c1C to have a higher LogP value.,C=CC[C@@H]1CC=C[C@@H](c2ccccc2)N1C(=O)CCc1c(C)nn(C)c1C,4.444040000000004
214022,Please modify the molecule CC(=O)Nc1ccc(OC(=O)[C@H](NC(=O)c2cccs2)C(C)C)cc1 to decrease its LogP value.,CC(=O)Nc1ccc(OC(=O)[C@H](NC(=O)c2cccs2)C(C)C)cc1,3.0665000000000013
16255,Modify the molecule COc1ccc(/C=C\C(=O)N2CCN(c3nccn3-c3ccc(C)cc3)CC2)cc1OC to have a lower LogP value.,COc1ccc(/C=C\C(=O)N2CCN(c3nccn3-c3ccc(C)cc3)CC2)cc1OC,3.5599200000000026
82853,Modify the molecule Cn1c(-c2nnc(SCC(=O)Nc3cccc(F)c3)o2)cc2ccccc21 to increase its LogP value.,Cn1c(-c2nnc(SCC(=O)Nc3cccc(F)c3)o2)cc2ccccc21,4.098200000000002
104576,Please optimize the molecule CC1(C)Cc2cc([C@@H]3NC(=O)[C@@H]4CCCCN43)ccc2O1 to have a higher LogP value.,CC1(C)Cc2cc([C@@H]3NC(=O)[C@@H]4CCCCN43)ccc2O1,2.383
248398,Modify the molecule Cc1ccc2c(Nc3ccc(C)c(C)c3)c(C(=O)N3CCCC[C@@H]3C)cnc2n1 to have a lower LogP value.,Cc1ccc2c(Nc3ccc(C)c(C)c3)c(C(=O)N3CCCC[C@@H]3C)cnc2n1,5.313260000000005
107722,Optimize the molecule S=C(NCc1ccco1)Nc1ccc(Nc2ccccc2)cc1 to have a higher LogP value.,S=C(NCc1ccco1)Nc1ccc(Nc2ccccc2)cc1,4.509800000000002
216348,Optimize the molecule Cc1nn(C)cc1C[NH+]1CCCCC[C@@H]1c1cccc(F)c1 to have a lower LogP value.,Cc1nn(C)cc1C[NH+]1CCCCC[C@@H]1c1cccc(F)c1,2.56782
224406,Optimize the molecule CC[C@@H](CNC(=O)N[C@@H]1CCC[C@@H]1C(N)=O)c1ccccc1 to have a lower LogP value.,CC[C@@H](CNC(=O)N[C@@H]1CCC[C@@H]1C(N)=O)c1ccccc1,2.133399999999999
182209,Modify the molecule O=C(COc1cccc(-c2nnco2)c1)N(C1CCCC1)C1CC1 to increase its LogP value.,O=C(COc1cccc(-c2nnco2)c1)N(C1CCCC1)C1CC1,3.0490000000000013
198116,Modify the molecule C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1 to have a higher LogP value.,C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1,-2.683619999999995
174823,Please modify the molecule COc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccc(F)cc1)cn2CC(=O)Nc1cc(C)ccc1C to increase its LogP value.,COc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccc(F)cc1)cn2CC(=O)Nc1cc(C)ccc1C,4.237540000000003
95154,Modify the molecule CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O to have a lower LogP value.,CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O,1.6733000000000005
71370,Please modify the molecule COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC to increase its LogP value.,COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC,4.482200000000004
84116,Please optimize the molecule CC(CO)(CO)NC(=O)CN1CCN(c2ccc(F)cc2)C1=O to have a higher LogP value.,CC(CO)(CO)NC(=O)CN1CCN(c2ccc(F)cc2)C1=O,-0.07279999999999998
150676,Please modify the molecule CCOc1ccc(C2(CNC(=O)c3ccc(Br)cc3F)CCOCC2)cc1 to increase its LogP value.,CCOc1ccc(C2(CNC(=O)c3ccc(Br)cc3F)CCOCC2)cc1,4.465100000000003
120006,Please modify the molecule O=C(C[C@H](O)c1cccc(F)c1)N1CCC[C@H]1c1cccc2c1OCCO2 to decrease its LogP value.,O=C(C[C@H](O)c1cccc(F)c1)N1CCC[C@H]1c1cccc2c1OCCO2,3.384100000000002
25013,Please modify the molecule Cc1ccc2c(CC(=O)N3CCN(S(=O)(=O)/C=C/c4ccccc4)CC3)coc2c1 to decrease its LogP value.,Cc1ccc2c(CC(=O)N3CCN(S(=O)(=O)/C=C/c4ccccc4)CC3)coc2c1,3.428620000000002
204720,Please modify the molecule O=C(CN1C(=O)S/C(=C\c2ccncc2)C1=O)N1CCOCC1 to decrease its LogP value.,O=C(CN1C(=O)S/C(=C\c2ccncc2)C1=O)N1CCOCC1,0.9767000000000002
156113,Modify the molecule CC(C)C[C@@H](O)C1CC[NH+](Cc2cc(F)cc(Cl)c2)CC1 to have a higher LogP value.,CC(C)C[C@@H](O)C1CC[NH+](Cc2cc(F)cc(Cl)c2)CC1,2.681000000000001
6747,Modify the molecule C[C@H](C(=O)Nc1cnn(C)c1)N1CC2(CCOCC2)Oc2ccccc2C1=O to have a lower LogP value.,C[C@H](C(=O)Nc1cnn(C)c1)N1CC2(CCOCC2)Oc2ccccc2C1=O,1.831099999999999
168148,Please optimize the molecule Cc1cccnc1CN1CCN(c2[nH+]ncc3ccccc23)CC1 to have a higher LogP value.,Cc1cccnc1CN1CCN(c2[nH+]ncc3ccccc23)CC1,2.0745199999999997
99736,Optimize the molecule C[C@@H]1[NH2+]C2(CCCCC2)CO[C@@H]1C to have a lower LogP value.,C[C@@H]1[NH2+]C2(CCCCC2)CO[C@@H]1C,1.0598999999999994
234079,Optimize the molecule O=C(c1ccc(NCc2ccccc2)nc1)N1CCCN(c2ncccn2)CC1 to have a lower LogP value.,O=C(c1ccc(NCc2ccccc2)nc1)N1CCCN(c2ncccn2)CC1,2.8362000000000007
171188,Please modify the molecule Cc1cc(F)cc(C(=O)N2C[C@H](C(N)=O)CC[C@H]2C)c1 to increase its LogP value.,Cc1cc(F)cc(C(=O)N2C[C@H](C(N)=O)CC[C@H]2C)c1,1.8601199999999998
133616,Please modify the molecule CCSC[C@@H](C)N(C)C(=O)CCn1cc(C)cn1 to increase its LogP value.,CCSC[C@@H](C)N(C)C(=O)CCn1cc(C)cn1,2.1816199999999997
9220,Please optimize the molecule CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1 to have a higher LogP value.,CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1,0.33610000000000206
63275,Modify the molecule Cc1ccc(C(=O)NC(Nc2c(C)n(C)n(-c3ccccc3)c2=O)(C(F)(F)F)C(F)(F)F)cc1 to decrease its LogP value.,Cc1ccc(C(=O)NC(Nc2c(C)n(C)n(-c3ccccc3)c2=O)(C(F)(F)F)C(F)(F)F)cc1,4.455640000000003
21393,Please optimize the molecule Cc1cc([C@H](C)NS(=O)(=O)c2cc3c(cc2Cl)NC(=O)CO3)c(C)o1 to have a higher LogP value.,Cc1cc([C@H](C)NS(=O)(=O)c2cc3c(cc2Cl)NC(=O)CO3)c(C)o1,2.9202400000000006
208992,Please modify the molecule C=Cc1ccc(Cn2nc3n(C)c(=O)c4ccc(C(=O)N[C@@H](C)CC)cc4n3c2=O)cc1 to increase its LogP value.,C=Cc1ccc(Cn2nc3n(C)c(=O)c4ccc(C(=O)N[C@@H](C)CC)cc4n3c2=O)cc1,2.567500000000001
88072,Optimize the molecule Cc1ccncc1NC(=O)NCCn1cc[nH+]c1 to have a higher LogP value.,Cc1ccncc1NC(=O)NCCn1cc[nH+]c1,0.8273199999999998
156483,Modify the molecule COCc1cc(C(=O)N(Cc2ccco2)C[C@@H]2CCCO2)no1 to have a higher LogP value.,COCc1cc(C(=O)N(Cc2ccco2)C[C@@H]2CCCO2)no1,2.2354000000000003
56294,Modify the molecule Cc1ccc([C@H]2c3c(oc4cc(C)c(Cl)cc4c3=O)C(=O)N2CCN2CCOCC2)cc1 to have a higher LogP value.,Cc1ccc([C@H]2c3c(oc4cc(C)c(Cl)cc4c3=O)C(=O)N2CCN2CCOCC2)cc1,3.940640000000003
122594,Modify the molecule Cc1ccc(S(=O)(=O)CCC(=O)Oc2ccc(Cl)cc2Cl)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)CCC(=O)Oc2ccc(Cl)cc2Cl)cc1,4.071220000000003
236967,Please modify the molecule Cc1cnc(C(C)(C)NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)s1 to increase its LogP value.,Cc1cnc(C(C)(C)NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)s1,4.071920000000003
102886,Modify the molecule COc1cccc(OCC2CCN(C(=O)c3cnc4c(c3)NC(=O)CO4)CC2)c1 to have a lower LogP value.,COc1cccc(OCC2CCN(C(=O)c3cnc4c(c3)NC(=O)CO4)CC2)c1,2.3523000000000005
179097,Modify the molecule O=C(c1c[nH]c2ncccc12)N1CCC[C@H]1Cn1cccn1 to increase its LogP value.,O=C(c1c[nH]c2ncccc12)N1CCC[C@H]1Cn1cccn1,2.0641999999999996
220907,Please optimize the molecule Cc1cccc(C)c1NC(=O)N[C@H](C)c1ccc(-c2cncnc2)cc1 to have a lower LogP value.,Cc1cccc(C)c1NC(=O)N[C@H](C)c1ccc(-c2cncnc2)cc1,4.643140000000003
70793,Please modify the molecule Cc1nonc1NC(=O)c1cccc(C(F)(F)F)c1 to increase its LogP value.,Cc1nonc1NC(=O)c1cccc(C(F)(F)F)c1,2.649120000000001
113516,Modify the molecule CN(C)c1ncnc(NCc2ccc(Cl)cc2)c1[N+](=O)[O-] to decrease its LogP value.,CN(C)c1ncnc(NCc2ccc(Cl)cc2)c1[N+](=O)[O-],2.7163000000000013
112069,Please optimize the molecule Cc1cc(C)c(N(C=O)C(=O)[C@H]2[C@H](C)[C@@H]3C=C[C@H]2C32CC2)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(N(C=O)C(=O)[C@H]2[C@H](C)[C@@H]3C=C[C@H]2C32CC2)c(C)c1,3.9495600000000035
155625,Modify the molecule Cc1ccccc1Cc1noc(C[NH+](C[C@H](C)O)C2CCCCC2)n1 to increase its LogP value.,Cc1ccccc1Cc1noc(C[NH+](C[C@H](C)O)C2CCCCC2)n1,2.06722
246491,Optimize the molecule C=C(Cl)CN1C[C@@H](c2ccccc2C)OC[C@H]1C to have a lower LogP value.,C=C(Cl)CN1C[C@@H](c2ccccc2C)OC[C@H]1C,3.5093200000000024
187615,Please optimize the molecule c1cc(-c2nc(C3CC3)no2)c2cc[nH]c2c1 to have a lower LogP value.,c1cc(-c2nc(C3CC3)no2)c2cc[nH]c2c1,3.095300000000001
62238,Please optimize the molecule CCOc1ccc2c(c1)=[NH+][C@@H](SCC(=O)Nc1ccc(Cl)cn1)[NH+]=2 to have a lower LogP value.,CCOc1ccc2c(c1)=[NH+][C@@H](SCC(=O)Nc1ccc(Cl)cn1)[NH+]=2,-1.7967999999999966
12501,Please modify the molecule Cc1ccc2ncc(CN3CCN(Cc4ccc(Cl)nc4)CC3)n2c1 to decrease its LogP value.,Cc1ccc2ncc(CN3CCN(Cc4ccc(Cl)nc4)CC3)n2c1,3.0089200000000016
118757,Modify the molecule CCC[C@@H](C)[C@H]([NH2+]CC)[C@@H](C)c1ccncc1 to have a lower LogP value.,CCC[C@@H](C)[C@H]([NH2+]CC)[C@@H](C)c1ccncc1,2.573200000000001
134729,Optimize the molecule O=C(c1ccc(N2CCCS2(=O)=O)cc1)N(CCCN1CCOCC1)c1ccccc1 to have a lower LogP value.,O=C(c1ccc(N2CCCS2(=O)=O)cc1)N(CCCN1CCOCC1)c1ccccc1,2.5956
16706,Modify the molecule CC(C)Cn1cc(NC(=O)C[C@H](NC(N)=O)c2cccs2)cn1 to have a lower LogP value.,CC(C)Cn1cc(NC(=O)C[C@H](NC(N)=O)c2cccs2)cn1,2.3388
41704,Modify the molecule COc1ccc(OC)c([C@@H]2CCCN2C(=O)CSc2nnnn2-c2ccc(O)cc2)c1 to have a lower LogP value.,COc1ccc(OC)c([C@@H]2CCCN2C(=O)CSc2nnnn2-c2ccc(O)cc2)c1,2.8409000000000013
209043,Optimize the molecule CC(C)(C[NH2+][C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1)NS(C)(=O)=O to have a lower LogP value.,CC(C)(C[NH2+][C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1)NS(C)(=O)=O,-0.8377999999999945
207312,Please optimize the molecule C#CCN1CCN(c2cccc(F)c2[N+](=O)[O-])CC1 to have a lower LogP value.,C#CCN1CCN(c2cccc(F)c2[N+](=O)[O-])CC1,1.4891
69671,Modify the molecule C[C@H](c1nc2ccccc2s1)[NH+](C)CC(=O)Nc1ccc2c(c1)OCCCO2 to have a lower LogP value.,C[C@H](c1nc2ccccc2s1)[NH+](C)CC(=O)Nc1ccc2c(c1)OCCCO2,2.6720000000000006
134486,Please modify the molecule CC(C)Oc1nnc(SCc2nc3ccccc3c(=O)[nH]2)s1 to decrease its LogP value.,CC(C)Oc1nnc(SCc2nc3ccccc3c(=O)[nH]2)s1,2.8541000000000007
68337,Please modify the molecule CC(C)n1cc(NC(=O)Nc2cccnc2Cl)cn1 to increase its LogP value.,CC(C)n1cc(NC(=O)Nc2cccnc2Cl)cn1,3.1564000000000005
224215,Please optimize the molecule O=S(=O)(CCN1CCN(c2ccccc2)CC1)c1ccccc1 to have a lower LogP value.,O=S(=O)(CCN1CCN(c2ccccc2)CC1)c1ccccc1,2.2824999999999998
166401,Please optimize the molecule Cc1ccc(OCCC[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc1 to have a higher LogP value.,Cc1ccc(OCCC[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc1,4.338620000000004
102463,Optimize the molecule CN(Cc1cccs1)C(=O)CSc1ccc2ccccc2n1 to have a higher LogP value.,CN(Cc1cccs1)C(=O)CSc1ccc2ccccc2n1,4.047000000000003
8769,Modify the molecule COc1ccccc1[C@H]1CC(=O)N=C(SCC(=O)Nc2nccs2)[C@H]1C#N to decrease its LogP value.,COc1ccccc1[C@H]1CC(=O)N=C(SCC(=O)Nc2nccs2)[C@H]1C#N,3.075780000000001
10427,Modify the molecule CC(C)[C@]1(O)CN(C(=O)CNC(N)=O)C[C@H]1C to have a higher LogP value.,CC(C)[C@]1(O)CN(C(=O)CNC(N)=O)C[C@H]1C,-0.4798999999999989
61624,Please modify the molecule Cc1ncsc1CN(Cc1ccccc1)C(=O)C1=NNC(=O)CC1 to increase its LogP value.,Cc1ncsc1CN(Cc1ccccc1)C(=O)C1=NNC(=O)CC1,2.24632
127483,Please modify the molecule COc1ccc(-c2nnn(CC(=O)Nc3cccc(Br)c3)n2)cc1OC to decrease its LogP value.,COc1ccc(-c2nnn(CC(=O)Nc3cccc(Br)c3)n2)cc1OC,2.7585000000000006
246082,Please modify the molecule CCC(=O)Nc1cccc(NC(=O)N2CCC(CCc3ccccc3)CC2)c1 to increase its LogP value.,CCC(=O)Nc1cccc(NC(=O)N2CCC(CCc3ccccc3)CC2)c1,4.911800000000004
161272,Modify the molecule Cc1c(F)cc(C(N)=O)cc1NC(=O)c1ncccc1C(F)(F)F to increase its LogP value.,Cc1c(F)cc(C(N)=O)cc1NC(=O)c1ncccc1C(F)(F)F,2.899120000000001
172542,Please modify the molecule Cc1oc(C)c(C(=O)NCc2ccc(C[NH+]3CCCC3)cc2)c1C to decrease its LogP value.,Cc1oc(C)c(C(=O)NCc2ccc(C[NH+]3CCCC3)cc2)c1C,2.31356
153302,Please modify the molecule C[C@H](Oc1cc(Cl)ccc1Cl)C(=O)NC[C@@H]1CCCO1 to increase its LogP value.,C[C@H](Oc1cc(Cl)ccc1Cl)C(=O)NC[C@@H]1CCCO1,3.055900000000001
82491,Modify the molecule Cc1cc(Br)ccc1NS(=O)(=O)c1cccc(C#N)c1 to have a lower LogP value.,Cc1cc(Br)ccc1NS(=O)(=O)c1cccc(C#N)c1,3.4300000000000015
90807,Please optimize the molecule CCc1ccc(O)c(NC(=O)[C@@H](C[NH3+])c2ccccc2)c1 to have a lower LogP value.,CCc1ccc(O)c(NC(=O)[C@@H](C[NH3+])c2ccccc2)c1,1.9187999999999996
180198,Modify the molecule Cc1ccc(NC(=O)c2c(C)oc3ccc(O)c(C[NH+]4CCCCC4)c23)cc1 to increase its LogP value.,Cc1ccc(NC(=O)c2c(C)oc3ccc(O)c(C[NH+]4CCCCC4)c23)cc1,3.5763400000000027
7797,Modify the molecule O=C(NC1CC[NH+](CC2(O)CCCCC2)CC1)c1nc2ccccc2s1 to increase its LogP value.,O=C(NC1CC[NH+](CC2(O)CCCCC2)CC1)c1nc2ccccc2s1,1.7686000000000002
159851,Modify the molecule C#CCNC(=O)[C@@H]1CCO[C@H]1C to increase its LogP value.,C#CCNC(=O)[C@@H]1CCO[C@H]1C,0.16080000000000005
23835,Please optimize the molecule Cc1cc(NC(=O)c2cc(Cl)c[nH]2)n(Cc2ccccn2)n1 to have a higher LogP value.,Cc1cc(NC(=O)c2cc(Cl)c[nH]2)n(Cc2ccccn2)n1,2.86862
206791,Please modify the molecule CC(=O)c1cccc(NCC(=O)N2CCCc3ccccc32)c1 to increase its LogP value.,CC(=O)c1cccc(NCC(=O)N2CCCc3ccccc32)c1,3.2805000000000017
140949,Please optimize the molecule CC1(C)CCC[C@@H]1NC(=O)NC[C@@H](O)C1CCCC1 to have a lower LogP value.,CC1(C)CCC[C@@H]1NC(=O)NC[C@@H](O)C1CCCC1,2.4154
108079,Please optimize the molecule Cc1ccc2oc(=O)n(CC(=O)N3CCC[C@@]4(CCOC4)C3)c2c1 to have a lower LogP value.,Cc1ccc2oc(=O)n(CC(=O)N3CCC[C@@]4(CCOC4)C3)c2c1,1.9320199999999998
29013,Modify the molecule CCNC(=O)Cc1cc(-c2ccc(C)cc2)on1 to have a lower LogP value.,CCNC(=O)Cc1cc(-c2ccc(C)cc2)on1,2.32862
32765,Please modify the molecule Cc1noc(C)c1[C@@H](C)NC(=O)CCOc1ccc2ccccc2c1 to decrease its LogP value.,Cc1noc(C)c1[C@@H](C)NC(=O)CCOc1ccc2ccccc2c1,4.090940000000003
199318,Modify the molecule Cc1n[nH]c(C)c1C[C@H](C)C(=O)Nc1ccc(CN2CCOCC2)cc1 to have a higher LogP value.,Cc1n[nH]c(C)c1C[C@H](C)C(=O)Nc1ccc(CN2CCOCC2)cc1,2.6760400000000004
19323,Optimize the molecule O=C(Cn1cnc2cc(F)ccc2c1=O)NCc1ccco1 to have a higher LogP value.,O=C(Cn1cnc2cc(F)ccc2c1=O)NCc1ccco1,1.445
189179,Please modify the molecule O=C(N[C@]1(C(=O)[O-])CCSC1)c1nnn[n-]1 to decrease its LogP value.,O=C(N[C@]1(C(=O)[O-])CCSC1)c1nnn[n-]1,-2.8157999999999994
35737,Please optimize the molecule Cc1ccc(-c2nnc(S[C@@H](C)C(=O)Nc3nc(-c4ccccc4)cs3)n2N)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(S[C@@H](C)C(=O)Nc3nc(-c4ccccc4)cs3)n2N)cc1,4.210120000000002
176270,Modify the molecule CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc(-c2nnco2)cc1 to have a higher LogP value.,CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc(-c2nnco2)cc1,4.080800000000003
66081,Please modify the molecule Cc1ccc([C@@H](N)c2cc(Br)ccc2Cl)s1 to increase its LogP value.,Cc1ccc([C@@H](N)c2cc(Br)ccc2Cl)s1,4.520520000000001
63607,Modify the molecule O=C(c1cnccn1)N1CC[C@H](n2cnnc2-c2ccccc2)C1 to have a higher LogP value.,O=C(c1cnccn1)N1CC[C@H](n2cnnc2-c2ccccc2)C1,1.8223
52074,Please modify the molecule Cc1nc2c(c(C)c1CCC(=O)N1CCCSCC1)c(=O)[nH]n2C to decrease its LogP value.,Cc1nc2c(c(C)c1CCC(=O)N1CCCSCC1)c(=O)[nH]n2C,1.7765399999999998
4248,Please modify the molecule CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1 to decrease its LogP value.,CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1,4.784000000000003
101152,Modify the molecule COc1ccc([C@@H]2OCC[C@H]2C[NH2+]C(C)C)cc1F to have a lower LogP value.,COc1ccc([C@@H]2OCC[C@H]2C[NH2+]C(C)C)cc1F,1.8837
140857,Optimize the molecule C[NH+](C)CC(C)(C)CNS(=O)(=O)C[C@@]12CC[C@@H](CC1=O)C2(C)C to have a higher LogP value.,C[NH+](C)CC(C)(C)CNS(=O)(=O)C[C@@]12CC[C@@H](CC1=O)C2(C)C,0.47190000000000265
238191,Optimize the molecule CCCN(CC#N)Cc1csc2ccccc12 to have a lower LogP value.,CCCN(CC#N)Cc1csc2ccccc12,3.6368800000000023
158888,Modify the molecule CC(C)(C)C(=O)Nc1ccc(NC(=O)c2ccccc2O)cc1 to decrease its LogP value.,CC(C)(C)C(=O)Nc1ccc(NC(=O)c2ccccc2O)cc1,3.629100000000001
246756,Optimize the molecule CC1=C[C@H]2C(=O)NC(CSCC(=O)Nc3ncc(C)s3)=N[C@H]2S1 to have a lower LogP value.,CC1=C[C@H]2C(=O)NC(CSCC(=O)Nc3ncc(C)s3)=N[C@H]2S1,2.24442
87859,Optimize the molecule CN[C@]1(C#N)CC[C@H](SCCS(C)(=O)=O)C1 to have a lower LogP value.,CN[C@]1(C#N)CC[C@H](SCCS(C)(=O)=O)C1,0.7984799999999999
242949,Please modify the molecule Cc1ccc(CN(C(=O)Nc2ccccc2)[C@H]2CCS(=O)(=O)C2)cc1 to increase its LogP value.,Cc1ccc(CN(C(=O)Nc2ccccc2)[C@H]2CCS(=O)(=O)C2)cc1,3.2162200000000016
11870,Modify the molecule CCn1c(SCC(=O)N[C@H]2CCC[C@@H](C)[C@@H]2C)nc2sc(C)c(C)c2c1=O to decrease its LogP value.,CCn1c(SCC(=O)N[C@H]2CCC[C@@H](C)[C@@H]2C)nc2sc(C)c(C)c2c1=O,4.127740000000004
173729,Modify the molecule CCOc1cc(NCc2cn[nH]c2N)ccc1[N+](=O)[O-] to increase its LogP value.,CCOc1cc(NCc2cn[nH]c2N)ccc1[N+](=O)[O-],1.9108999999999998
119331,Please optimize the molecule C[C@H](NC(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)C(N)=O to have a lower LogP value.,C[C@H](NC(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)C(N)=O,-1.7696999999999994
239035,Modify the molecule CC(C)Cn1c(S[C@@H](C)C(=O)N(C)C)nc2sc3c(c2c1=O)CC[C@H](C)C3 to increase its LogP value.,CC(C)Cn1c(S[C@@H](C)C(=O)N(C)C)nc2sc3c(c2c1=O)CC[C@H](C)C3,3.8076000000000025
32994,Modify the molecule CCOc1cccc([C@H]2NC(=O)[C@@H]3COCCN32)c1OC(F)F to have a lower LogP value.,CCOc1cccc([C@H]2NC(=O)[C@@H]3COCCN32)c1OC(F)F,1.5158999999999998
212697,Please modify the molecule COc1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cn1 to increase its LogP value.,COc1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cn1,2.4649
235673,Modify the molecule C[C@@H](C#N)[C@@](C)(O)c1cccc(Cl)c1 to have a lower LogP value.,C[C@@H](C#N)[C@@](C)(O)c1cccc(Cl)c1,2.707180000000001
199113,Optimize the molecule COCCOc1ccccc1CNc1cc(C)ccc1C to have a lower LogP value.,COCCOc1ccccc1CNc1cc(C)ccc1C,3.9407400000000026
146386,Optimize the molecule COc1ccc([C@@]2(O)CC(c3ccc(F)cc3)=[N+]3CCCCCN32)cc1 to have a lower LogP value.,COc1ccc([C@@]2(O)CC(c3ccc(F)cc3)=[N+]3CCCCCN32)cc1,3.285800000000002
211536,Modify the molecule NC(=O)CSc1ccccc1NC(=O)Cc1cccs1 to have a higher LogP value.,NC(=O)CSc1ccccc1NC(=O)Cc1cccs1,2.5067000000000013
172704,Modify the molecule CCC(C)(C)NC(=O)[C@@H](C)S(=O)(=O)Cc1ccc(C(C)(C)C)cc1 to have a lower LogP value.,CCC(C)(C)NC(=O)[C@@H](C)S(=O)(=O)Cc1ccc(C(C)(C)C)cc1,3.5922000000000027
245756,Please optimize the molecule C[C@@H]1CC[C@H](C(N)=O)CN1C(=O)c1ccc(Br)cc1F to have a lower LogP value.,C[C@@H]1CC[C@H](C(N)=O)CN1C(=O)c1ccc(Br)cc1F,2.3141999999999996
170555,Please optimize the molecule O=C(OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C[C@H]1c1ccccc1F to have a higher LogP value.,O=C(OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C[C@H]1c1ccccc1F,3.5808000000000018
207723,Optimize the molecule COc1cccc(CCNC(=O)c2cc3c(Cl)cccc3n2C)c1 to have a higher LogP value.,COc1cccc(CCNC(=O)c2cc3c(Cl)cccc3n2C)c1,3.812800000000002
120324,Optimize the molecule C[C@H](C(=O)N1CCC[C@H](C(N)=O)C1)[NH+](C)Cc1cccc(N(C)C)c1 to have a lower LogP value.,C[C@H](C(=O)N1CCC[C@H](C(N)=O)C1)[NH+](C)Cc1cccc(N(C)C)c1,-0.12029999999999652
47492,Please optimize the molecule C[C@@H]1C[C@H](NC(=O)CCCNC(=O)c2ccccc2)CN1c1ccccc1 to have a lower LogP value.,C[C@@H]1C[C@H](NC(=O)CCCNC(=O)c2ccccc2)CN1c1ccccc1,2.980200000000001
242120,Optimize the molecule Cc1ccc([S@](=O)Cc2nc(-c3ccc(C(=O)NCc4ccccc4)cc3)oc2C)cc1 to have a lower LogP value.,Cc1ccc([S@](=O)Cc2nc(-c3ccc(C(=O)NCc4ccccc4)cc3)oc2C)cc1,5.196240000000005
15252,Please optimize the molecule Cc1[nH]c(-c2ccc(OCC(=O)[O-])cc2)[nH+]c1C to have a higher LogP value.,Cc1[nH]c(-c2ccc(OCC(=O)[O-])cc2)[nH+]c1C,0.24133999999999972
35096,Modify the molecule CNC(=S)N/N=C/c1cc(OC)cc(OC)c1 to have a higher LogP value.,CNC(=S)N/N=C/c1cc(OC)cc(OC)c1,1.1316
202853,Please optimize the molecule CNC(=O)c1c(NC(=O)[C@H](C)SC)sc2c1-c1ccccc1C2 to have a lower LogP value.,CNC(=O)c1c(NC(=O)[C@H](C)SC)sc2c1-c1ccccc1C2,3.368900000000002
72355,Modify the molecule COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C to have a higher LogP value.,COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C,3.3215000000000012
85126,Modify the molecule CCCCC[C@H](Br)[C@H](C)c1ccncc1 to have a lower LogP value.,CCCCC[C@H](Br)[C@H](C)c1ccncc1,4.528900000000004
149209,Optimize the molecule COc1ccc(COCCNC(=O)[C@@]2(C)CCCS2)cc1 to have a higher LogP value.,COc1ccc(COCCNC(=O)[C@@]2(C)CCCS2)cc1,2.6137000000000006
196605,Modify the molecule O=C(NCc1cccnc1)C1CC[NH+](Cc2ccccc2O)CC1 to have a higher LogP value.,O=C(NCc1cccnc1)C1CC[NH+](Cc2ccccc2O)CC1,0.8985000000000001
105862,Please modify the molecule Cc1nnc(SCC(=O)Nc2ccc(F)c(Cl)c2)n1-n1cccc1 to increase its LogP value.,Cc1nnc(SCC(=O)Nc2ccc(F)c(Cl)c2)n1-n1cccc1,3.2227200000000007
77759,Please optimize the molecule CC(C)N(C(=O)[C@H](C)Oc1ccc(F)c(F)c1)C1CCC1 to have a higher LogP value.,CC(C)N(C(=O)[C@H](C)Oc1ccc(F)c(F)c1)C1CCC1,3.521600000000002
167010,Modify the molecule C[C@H]1CC[C@H](C)N(C(=O)c2cc(C(C)(C)C)nn2C)C1 to decrease its LogP value.,C[C@H]1CC[C@H](C)N(C(=O)c2cc(C(C)(C)C)nn2C)C1,2.978200000000001
51149,Please optimize the molecule O=C(CO)[C@H](O)[C@@H](O)CO to have a higher LogP value.,O=C(CO)[C@H](O)[C@@H](O)CO,-2.7381000000000006
169625,Please modify the molecule O=c1[nH]ncc(N[C@@H]2CCCC[C@@H]2OC2CCCC2)c1Cl to increase its LogP value.,O=c1[nH]ncc(N[C@@H]2CCCC[C@@H]2OC2CCCC2)c1Cl,3.105600000000001
100505,Please modify the molecule CCC[C@@H](C[NH3+])[C@H](O)CCC1CCCCC1 to decrease its LogP value.,CCC[C@@H](C[NH3+])[C@H](O)CCC1CCCCC1,2.3659999999999997
229954,Optimize the molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cc(C2CC2)[nH]n1 to have a lower LogP value.,C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cc(C2CC2)[nH]n1,2.7004
25478,Please modify the molecule Cc1cccc(C)c1NC(=O)CCCN1CCOC[C@@H]1C1CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)CCCN1CCOC[C@@H]1C1CC1,3.1329400000000014
157950,Modify the molecule Cc1ccc([C@@H](O)CNC(=O)Nc2ccc(C)cc2F)cc1 to decrease its LogP value.,Cc1ccc([C@@H](O)CNC(=O)Nc2ccc(C)cc2F)cc1,3.2976400000000012
195208,Please modify the molecule CN(C)C(=O)N1CCN(C(=O)Nc2ccc([N+](=O)[O-])cc2)CC1 to increase its LogP value.,CN(C)C(=O)N1CCN(C(=O)Nc2ccc([N+](=O)[O-])cc2)CC1,1.4259
163348,Optimize the molecule COC[C@H](NC(=O)Cc1ccc(C)c(O)c1)c1ccc(C)o1 to have a lower LogP value.,COC[C@H](NC(=O)Cc1ccc(C)c(O)c1)c1ccc(C)o1,2.648440000000001
14664,Modify the molecule CCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC(C(C)(C)C)CC2)C1 to increase its LogP value.,CCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC(C(C)(C)C)CC2)C1,-0.021899999999998032
85533,Please modify the molecule Cn1c(C[C@@H](O)c2ccccc2Cl)nc2ccccc21 to increase its LogP value.,Cn1c(C[C@@H](O)c2ccccc2Cl)nc2ccccc21,3.5028000000000024
17521,Please modify the molecule Cc1ccc(C)c(C[NH2+][C@H](C)c2ccc(C)c(F)c2)c1 to increase its LogP value.,Cc1ccc(C)c(C[NH2+][C@H](C)c2ccc(C)c(F)c2)c1,3.575560000000002
4573,Modify the molecule O=C(NCCC1=CCCCC1)c1ccccc1O to increase its LogP value.,O=C(NCCC1=CCCCC1)c1ccccc1O,3.0125000000000024
87596,Modify the molecule O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1 to decrease its LogP value.,O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1,1.4354999999999996
235491,Please optimize the molecule CCCC[NH2+]Cc1cccc(OC)c1 to have a higher LogP value.,CCCC[NH2+]Cc1cccc(OC)c1,1.5586999999999995
81250,Please modify the molecule CC(C)c1cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)n(C)n1 to decrease its LogP value.,CC(C)c1cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)n(C)n1,2.8393000000000015
132346,Please modify the molecule COc1ccc(NS(=O)(=O)c2c(C)nc3sccn3c2=O)cc1 to decrease its LogP value.,COc1ccc(NS(=O)(=O)c2c(C)nc3sccn3c2=O)cc1,1.8738199999999998
38463,Please optimize the molecule Cc1ccc(C)c(OC[C@H](O)Cn2cnc3c(Cl)cc(Cl)cc3c2=O)c1 to have a higher LogP value.,Cc1ccc(C)c(OC[C@H](O)Cn2cnc3c(Cl)cc(Cl)cc3c2=O)c1,3.7600400000000027
59964,Please optimize the molecule CCN(C(=O)c1ccc(NC(=O)C2CC2)cc1)c1ccccc1C to have a higher LogP value.,CCN(C(=O)c1ccc(NC(=O)C2CC2)cc1)c1ccccc1C,4.010220000000003
191096,Please optimize the molecule CC1(C)CSC[C@@]([NH2+]CCN=[N+]=[N-])(C(N)=O)C1 to have a higher LogP value.,CC1(C)CSC[C@@]([NH2+]CCN=[N+]=[N-])(C(N)=O)C1,0.2473000000000002
6190,Modify the molecule C[NH+](C)CCCC[NH2+][C@@H]1CC(C)(C)OC1(C)C to have a lower LogP value.,C[NH+](C)CCCC[NH2+][C@@H]1CC(C)(C)OC1(C)C,-0.17939999999999645
149569,Please modify the molecule Cc1ccc(NC(=O)C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)c(Cl)n1 to decrease its LogP value.,Cc1ccc(NC(=O)C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)c(Cl)n1,0.6573200000000008
160756,Modify the molecule COc1ccc(CO/N=C(/N)[C@H]2CCOC2)cc1F to have a higher LogP value.,COc1ccc(CO/N=C(/N)[C@H]2CCOC2)cc1F,1.6596
124654,Please modify the molecule COCCC(=O)N[C@@H](C)c1nnc2n1CCN(Cc1ccccc1C)CC2 to increase its LogP value.,COCCC(=O)N[C@@H](C)c1nnc2n1CCN(Cc1ccccc1C)CC2,1.8585199999999995
184653,Optimize the molecule CSc1nc(-c2ccccc2)c(NC(=O)COc2ccccc2F)s1 to have a higher LogP value.,CSc1nc(-c2ccccc2)c(NC(=O)COc2ccccc2F)s1,4.688600000000001
7988,Please modify the molecule CC1CC[NH+](CCCCNC(=O)c2ccc(-n3cc[nH]c3=S)cc2)CC1 to increase its LogP value.,CC1CC[NH+](CCCCNC(=O)c2ccc(-n3cc[nH]c3=S)cc2)CC1,2.3596899999999996
25400,Please optimize the molecule CC1CCC([C@H]2OCCC[C@H]2C[NH2+]C(C)C)CC1 to have a lower LogP value.,CC1CCC([C@H]2OCCC[C@H]2C[NH2+]C(C)C)CC1,2.5797
209054,Modify the molecule CC[C@H](C)[C@@H](C)[NH+](Cc1ccccc1NC(C)=O)C1CC1 to decrease its LogP value.,CC[C@H](C)[C@@H](C)[NH+](Cc1ccccc1NC(C)=O)C1CC1,2.6269
230493,Please optimize the molecule CC(=O)c1ccccc1C(=O)N(C)[C@@H]1CCCN(c2ccccc2)C1=O to have a higher LogP value.,CC(=O)c1ccccc1C(=O)N(C)[C@@H]1CCCN(c2ccccc2)C1=O,3.1568000000000023
232541,Optimize the molecule CCOC(=O)c1ccc(N2N=C(C)[C@@]3(Cc4ccccc4N4CCCC[C@@H]43)C2=O)cc1 to have a higher LogP value.,CCOC(=O)c1ccc(N2N=C(C)[C@@]3(Cc4ccccc4N4CCCC[C@@H]43)C2=O)cc1,4.187400000000004
65624,Please modify the molecule CCS(=O)(=O)N1CCC(NC(=O)[C@H](C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)CC1 to decrease its LogP value.,CCS(=O)(=O)N1CCC(NC(=O)[C@H](C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)CC1,0.25640000000000085
236601,Modify the molecule Cc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccnc4)n3C)c2C)no1 to have a higher LogP value.,Cc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccnc4)n3C)c2C)no1,3.5560600000000013
240411,Modify the molecule C[C@H]1CN(c2cc(CNC(=O)CCCC(C)(C)C)cc[nH+]2)CCO1 to have a higher LogP value.,C[C@H]1CN(c2cc(CNC(=O)CCCC(C)(C)C)cc[nH+]2)CCO1,2.5584000000000007
202455,Please modify the molecule CCOC(=O)/C(C#N)=C\c1ccc(N)cc1 to decrease its LogP value.,CCOC(=O)/C(C#N)=C\c1ccc(N)cc1,1.73888
87614,Please optimize the molecule O=C(CCn1ncc(=O)c2ccccc21)Oc1ccccc1-c1ccccc1 to have a lower LogP value.,O=C(CCn1ncc(=O)c2ccccc21)Oc1ccccc1-c1ccccc1,4.059200000000002
200741,Please optimize the molecule CN(C)C(=O)C[NH+]1CCC(NC(=O)/C=C/SCc2ccco2)CC1 to have a higher LogP value.,CN(C)C(=O)C[NH+]1CCC(NC(=O)/C=C/SCc2ccco2)CC1,0.27820000000000267
116049,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)Nc1cncc2ccccc12 to increase its LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)Nc1cncc2ccccc12,3.1990200000000018
223373,Modify the molecule COc1ccc([C@@H](C)NC(=O)c2cccc(Br)n2)c(OC)c1 to decrease its LogP value.,COc1ccc([C@@H](C)NC(=O)c2cccc(Br)n2)c(OC)c1,3.3523000000000014
165741,Modify the molecule COC(=O)[C@H](C)NC(=O)c1cc2cc(C)c(C)cc2o1 to increase its LogP value.,COC(=O)[C@H](C)NC(=O)c1cc2cc(C)c(C)cc2o1,2.34094
89454,Modify the molecule CCOc1cc(F)ccc1NC(=O)CC1(C(=O)[O-])CCCCC1 to have a lower LogP value.,CCOc1cc(F)ccc1NC(=O)CC1(C(=O)[O-])CCCCC1,2.2534
81317,Please modify the molecule CCc1ccccc1NC(=O)C(=O)NC1CCCC1 to increase its LogP value.,CCc1ccccc1NC(=O)C(=O)NC1CCCC1,2.2462999999999997
8664,Modify the molecule O=C(NC[C@@H]1CC[NH+](C2CC2)C1)N1CCN(c2nccs2)CC1 to have a lower LogP value.,O=C(NC[C@@H]1CC[NH+](C2CC2)C1)N1CCN(c2nccs2)CC1,0.041900000000000714
35936,Please optimize the molecule Cc1sc(C(=O)NNC(=O)CCOc2ccccc2)cc1[N+](=O)[O-] to have a lower LogP value.,Cc1sc(C(=O)NNC(=O)CCOc2ccccc2)cc1[N+](=O)[O-],2.19482
211219,Please modify the molecule CCOc1nc(-n2cnc3ccccc32)ccc1N to increase its LogP value.,CCOc1nc(-n2cnc3ccccc32)ccc1N,2.4013999999999998
42537,Please optimize the molecule O=C1C[C@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)[NH+]=c3ccccc3=C2O1 to have a higher LogP value.,O=C1C[C@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)[NH+]=c3ccccc3=C2O1,-0.8891999999999989
247768,Please modify the molecule CCCCC(=O)Nc1nc(-c2cc3cccc(OCC)c3o2)cs1 to increase its LogP value.,CCCCC(=O)Nc1nc(-c2cc3cccc(OCC)c3o2)cs1,5.083700000000004
21947,Please modify the molecule O=C=Nc1ccc2c(c1)O[C@@H](F)C(F)(F)O2 to increase its LogP value.,O=C=Nc1ccc2c(c1)O[C@@H](F)C(F)(F)O2,2.3135000000000003
52663,Optimize the molecule CC(C)(C)[C@H](NC(=O)c1cccc(C(F)(F)F)c1F)C(N)=O to have a higher LogP value.,CC(C)(C)[C@H](NC(=O)c1cccc(C(F)(F)F)c1F)C(N)=O,2.4742999999999995
174829,Optimize the molecule CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1 to have a higher LogP value.,CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1,2.5647
46443,Please optimize the molecule O=C(CCC(=O)N1CCOc2ccccc21)NCCCN1CCOCC1 to have a lower LogP value.,O=C(CCC(=O)N1CCOc2ccccc21)NCCCN1CCOCC1,1.0307000000000006
131976,Modify the molecule Cn1ncnc1NC(=O)N1CCCN(c2nccs2)CC1 to have a lower LogP value.,Cn1ncnc1NC(=O)N1CCCN(c2nccs2)CC1,1.0158
90118,Please modify the molecule CCOC(=O)c1c([O-])n(C)c2ccccc2c1=O to decrease its LogP value.,CCOC(=O)c1c([O-])n(C)c2ccccc2c1=O,0.7887999999999998
58858,Please optimize the molecule CC(C)COc1ccc(Cc2c([O-])nc(N)[nH]c2=O)cc1 to have a higher LogP value.,CC(C)COc1ccc(Cc2c([O-])nc(N)[nH]c2=O)cc1,1.0513
128578,Please modify the molecule CCCCC1CCC(C(=O)N2CCN(C(=O)[C@H]3CCCO3)CC2)CC1 to increase its LogP value.,CCCCC1CCC(C(=O)N2CCN(C(=O)[C@H]3CCCO3)CC2)CC1,2.8328000000000015
34381,Modify the molecule CC(C)n1cnnc1[S@](=O)[C@@H](C)C(=O)N[C@@H](C)c1ccc(F)cc1 to decrease its LogP value.,CC(C)n1cnnc1[S@](=O)[C@@H](C)C(=O)N[C@@H](C)c1ccc(F)cc1,2.3716
33707,Modify the molecule C[NH+](CCc1ccccc1F)C[C@@H]1CCCN(S(C)(=O)=O)C1 to decrease its LogP value.,C[NH+](CCc1ccccc1F)C[C@@H]1CCCN(S(C)(=O)=O)C1,0.5545000000000007
40059,Optimize the molecule Cc1ccc([C@@H](CNC(=O)N2CCC(C)(C)C2)N2CCOCC2)cc1 to have a lower LogP value.,Cc1ccc([C@@H](CNC(=O)N2CCC(C)(C)C2)N2CCOCC2)cc1,2.809820000000001
5785,Please modify the molecule C[C@@H]1CCN(C(=O)NCCC2CCCC2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)NCCC2CCCC2)C[C@@H]1O,1.9790000000000005
131799,Please modify the molecule COCCN1C(=O)/C(=C\C=C\c2ccccc2)SC1=S to increase its LogP value.,COCCN1C(=O)/C(=C\C=C\c2ccccc2)SC1=S,3.0904000000000016
224023,Please optimize the molecule COC(=O)[C@@]1(F)CCN(c2cncc(-n3nc(C)cc3C)n2)C1 to have a lower LogP value.,COC(=O)[C@@]1(F)CCN(c2cncc(-n3nc(C)cc3C)n2)C1,1.3705399999999999
246907,Modify the molecule CCn1cc(C(=O)NCc2ccc3c(c2)OCO3)c(=O)c2cc(S(=O)(=O)N3CCOCC3)ccc21 to decrease its LogP value.,CCn1cc(C(=O)NCc2ccc3c(c2)OCO3)c(=O)c2cc(S(=O)(=O)N3CCOCC3)ccc21,1.701
182073,Please modify the molecule CC(C)(C)C(=O)NCCCc1cc(N)n(-c2ccccc2)n1 to decrease its LogP value.,CC(C)(C)C(=O)NCCCc1cc(N)n(-c2ccccc2)n1,2.549400000000001
107508,Please modify the molecule Cc1cnc(-c2cccc(NC(=O)C(=O)NC[C@H](C(C)C)[NH+]3CCCC3)c2)o1 to decrease its LogP value.,Cc1cnc(-c2cccc(NC(=O)C(=O)NC[C@H](C(C)C)[NH+]3CCCC3)c2)o1,1.4080199999999998
118213,Modify the molecule Cc1ccc(CN[C@@H](CC(F)(F)F)c2ccc(F)cc2)cc1[N+](=O)[O-] to increase its LogP value.,Cc1ccc(CN[C@@H](CC(F)(F)F)c2ccc(F)cc2)cc1[N+](=O)[O-],4.825620000000003
15700,Modify the molecule O=C(CN1CCOCC1)N1CCN([C@@H]2CCN(c3ccccc3)C2=O)CC1 to decrease its LogP value.,O=C(CN1CCOCC1)N1CCN([C@@H]2CCN(c3ccccc3)C2=O)CC1,0.268300000000002
106123,Please modify the molecule C[NH2+]C/C(C)=C/C1CCCCC1 to decrease its LogP value.,C[NH2+]C/C(C)=C/C1CCCCC1,1.7061999999999995
16248,Please modify the molecule O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC2(CC1)[NH2+]CCC1=NC=N[C@@H]12)c1ccc2c(c1)OCO2 to increase its LogP value.,O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC2(CC1)[NH2+]CCC1=NC=N[C@@H]12)c1ccc2c(c1)OCO2,0.9362000000000019
185448,Modify the molecule CN(C)c1ccc(CNc2cc(C(=O)[O-])[nH]n2)cc1 to increase its LogP value.,CN(C)c1ccc(CNc2cc(C(=O)[O-])[nH]n2)cc1,0.4512999999999995
55649,Modify the molecule O=C(CCCC(=O)c1ccccc1)Nc1ccc(Cl)cn1 to decrease its LogP value.,O=C(CCCC(=O)c1ccccc1)Nc1ccc(Cl)cn1,3.726700000000002
117931,Optimize the molecule CCN(Cc1ccnc(Cl)c1)Cc1cccc(C)n1 to have a lower LogP value.,CCN(Cc1ccnc(Cl)c1)Cc1cccc(C)n1,3.4605200000000025
213002,Please optimize the molecule C[NH2+][C@H](c1cscc1C)[C@H]1CCOC2(CCC2)C1 to have a lower LogP value.,C[NH2+][C@H](c1cscc1C)[C@H]1CCOC2(CCC2)C1,2.6401200000000014
23994,Optimize the molecule CC[N+](CC)=C1S[C@H]2CS(=O)(=O)C[C@H]2S1 to have a higher LogP value.,CC[N+](CC)=C1S[C@H]2CS(=O)(=O)C[C@H]2S1,1.0402999999999998
11490,Please optimize the molecule C[C@H](Cc1ccsc1)NC(=O)[C@H]1C=C[C@@H]([NH3+])C1 to have a higher LogP value.,C[C@H](Cc1ccsc1)NC(=O)[C@H]1C=C[C@@H]([NH3+])C1,0.9819
103731,Please optimize the molecule COC[C@@H]1CCCN(C(=O)Cc2cccc(OC)c2)C1 to have a lower LogP value.,COC[C@@H]1CCCN(C(=O)Cc2cccc(OC)c2)C1,2.1227
96491,Modify the molecule C#Cc1cccc(N(C(=O)[C@H]2Cc3ccccc3O2)C(C)C)c1 to decrease its LogP value.,C#Cc1cccc(N(C(=O)[C@H]2Cc3ccccc3O2)C(C)C)c1,3.413000000000002
110066,Modify the molecule CCCN[C@]1(C#N)CCC[C@@H](n2cc(I)cn2)C1 to decrease its LogP value.,CCCN[C@]1(C#N)CCC[C@@H](n2cc(I)cn2)C1,2.8647800000000014
85711,Please optimize the molecule CCc1nc2n(n1)CCC[C@H]2NC(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1 to have a lower LogP value.,CCc1nc2n(n1)CCC[C@H]2NC(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1,3.160300000000002
58188,Optimize the molecule Cc1cccc(SCc2cc(N)cc[nH+]2)c1 to have a lower LogP value.,Cc1cccc(SCc2cc(N)cc[nH+]2)c1,2.6836200000000003
215419,Modify the molecule COc1ccccc1COC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1 to have a lower LogP value.,COc1ccccc1COC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1,3.941900000000003
152003,Please modify the molecule COCCCN1C(=O)c2[nH]nc(-c3ccccc3)c2[C@H]1c1cccc(F)c1 to increase its LogP value.,COCCCN1C(=O)c2[nH]nc(-c3ccccc3)c2[C@H]1c1cccc(F)c1,3.797500000000003
216449,Modify the molecule O=C(NCc1cccc([N+](=O)[O-])c1)Nc1ccc2c(c1)CCC2 to decrease its LogP value.,O=C(NCc1cccc([N+](=O)[O-])c1)Nc1ccc2c(c1)CCC2,3.4052000000000016
31240,Modify the molecule O=C(NCCC[NH+]1CCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2F)CC1 to have a higher LogP value.,O=C(NCCC[NH+]1CCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2F)CC1,0.5505000000000013
4601,Please modify the molecule CC(C)N(CC#N)C(=O)CC12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,CC(C)N(CC#N)C(=O)CC12CC3CC(CC(C3)C1)C2,3.353480000000002
216147,Modify the molecule CC(C)Oc1cccc(-c2nnc(CCC(=O)N3CCSCC3)c([O-])n2)c1 to have a lower LogP value.,CC(C)Oc1cccc(-c2nnc(CCC(=O)N3CCSCC3)c([O-])n2)c1,1.9073999999999998
214396,Modify the molecule FC(F)(F)c1ccc(NN2CCCCC2)cn1 to increase its LogP value.,FC(F)(F)c1ccc(NN2CCCCC2)cn1,2.9132000000000007
167824,Modify the molecule CN(CC(=O)NC(C)(C)C)C(=O)c1cc(N2CCCC2=O)ccc1Cl to increase its LogP value.,CN(CC(=O)NC(C)(C)C)C(=O)c1cc(N2CCCC2=O)ccc1Cl,2.4535
220261,Optimize the molecule COc1nc2ccccc2nc1NC[C@@H]1CCN(C(=O)OC(C)(C)C)C1 to have a higher LogP value.,COc1nc2ccccc2nc1NC[C@@H]1CCN(C(=O)OC(C)(C)C)C1,3.3073000000000023
112919,Modify the molecule Cc1nc(NC[C@H]([C@@H]2CCOC2)N2CCOCC2)c2cc[nH]c2n1 to increase its LogP value.,Cc1nc(NC[C@H]([C@@H]2CCOC2)N2CCOCC2)c2cc[nH]c2n1,1.4155199999999997
172454,Modify the molecule C[C@H](CN(C)C(=O)CCc1nc2ccccc2o1)C(=O)[O-] to increase its LogP value.,C[C@H](CN(C)C(=O)CCc1nc2ccccc2o1)C(=O)[O-],0.6048
86026,Please optimize the molecule O[C@@H](C[C@@H]1CCC[NH+]1Cc1cc[nH]n1)c1cccs1 to have a higher LogP value.,O[C@@H](C[C@@H]1CCC[NH+]1Cc1cc[nH]n1)c1cccs1,1.1421999999999997
43411,Please optimize the molecule CC[C@H](C)NC(=O)CCNC(=O)NCc1cccc(C)n1 to have a lower LogP value.,CC[C@H](C)NC(=O)CCNC(=O)NCc1cccc(C)n1,1.4940199999999995
149900,Modify the molecule C[N+](C)([O-])CC[C@H](c1ccc(Cl)cc1)c1ccccn1 to increase its LogP value.,C[N+](C)([O-])CC[C@H](c1ccc(Cl)cc1)c1ccccn1,3.8312000000000026
238441,Modify the molecule CCS(=O)(=O)c1ccc([C@H](C)N[C@@H](C)c2csc(C(C)C)n2)cc1 to decrease its LogP value.,CCS(=O)(=O)c1ccc([C@H](C)N[C@@H](C)c2csc(C(C)C)n2)cc1,4.471900000000003
53894,Please modify the molecule Cc1nccn1-c1cncc(N2CC[NH+]3CCCC[C@@H]3C2)n1 to increase its LogP value.,Cc1nccn1-c1cncc(N2CC[NH+]3CCCC[C@@H]3C2)n1,0.22812000000000032
224364,Please optimize the molecule C=CCN(CC=C)C(=O)[C@@H](C)Nc1ccc2c(c1)OCCO2 to have a lower LogP value.,C=CCN(CC=C)C(=O)[C@@H](C)Nc1ccc2c(c1)OCCO2,2.4588
171695,Modify the molecule CC(=O)N1CCc2ccccc2[C@@H]1CC(=O)N1Cc2ccccc2C[C@H]1C(N)=O to have a higher LogP value.,CC(=O)N1CCc2ccccc2[C@@H]1CC(=O)N1Cc2ccccc2C[C@H]1C(N)=O,1.9612
124745,Modify the molecule COc1nn(C)cc1C(=O)Nc1nc2c(cc3c4c(cccc42)CC3)s1 to decrease its LogP value.,COc1nn(C)cc1C(=O)Nc1nc2c(cc3c4c(cccc42)CC3)s1,3.542500000000002
57762,Modify the molecule CC(/C=C/c1ccco1)=N\NC1=N[C@@H]2[NH+]=c3ccccc3=C2N=[NH+]1 to have a higher LogP value.,CC(/C=C/c1ccco1)=N\NC1=N[C@@H]2[NH+]=c3ccccc3=C2N=[NH+]1,-1.990999999999996
150986,Please optimize the molecule O=C(CNC(=O)N1CC(O)=Nc2ccccc21)Nc1nccs1 to have a lower LogP value.,O=C(CNC(=O)N1CC(O)=Nc2ccccc21)Nc1nccs1,1.8994
16879,Modify the molecule O=C(Nc1ccc2c(c1)Cc1ccccc1-2)c1cc(=O)c2ccccc2o1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)Cc1ccccc1-2)c1cc(=O)c2ccccc2o1,4.616500000000003
173522,Please optimize the molecule Cc1cc2nc(SCC(=O)N3CCN(c4ccc(F)cc4)CC3)n(-c3ccc(F)cc3)c(=O)c2[nH]1 to have a higher LogP value.,Cc1cc2nc(SCC(=O)N3CCN(c4ccc(F)cc4)CC3)n(-c3ccc(F)cc3)c(=O)c2[nH]1,3.7413200000000018
222848,Please modify the molecule Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12 to increase its LogP value.,Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12,0.6908199999999995
96003,Modify the molecule Cc1n[nH]cc1CNC(=O)CSc1ccc(Br)cc1 to decrease its LogP value.,Cc1n[nH]cc1CNC(=O)CSc1ccc(Br)cc1,2.889120000000001
60924,Modify the molecule C[C@@H]1CCN(C(=O)NCCCc2ccc(N(C)C)cc2)C[C@@H]1O to have a lower LogP value.,C[C@@H]1CCN(C(=O)NCCCc2ccc(N(C)C)cc2)C[C@@H]1O,2.0975000000000006
122857,Modify the molecule CC(C)(C)n1nnn(CN(Cc2cccs2)CC(F)(F)F)c1=S to have a lower LogP value.,CC(C)(C)n1nnn(CN(Cc2cccs2)CC(F)(F)F)c1=S,3.6475900000000028
95019,Modify the molecule COc1cc2c(cc1OC)[C@@H]1c3ccccc3[C@](C#N)(C2)N(C(=O)c2ccccc2)[C@@H]1O to have a higher LogP value.,COc1cc2c(cc1OC)[C@@H]1c3ccccc3[C@](C#N)(C2)N(C(=O)c2ccccc2)[C@@H]1O,3.585080000000002
13999,Modify the molecule CC[NH+](CC)C1(C(=O)c2ccc(F)cc2)CCCC1 to decrease its LogP value.,CC[NH+](CC)C1(C(=O)c2ccc(F)cc2)CCCC1,2.2459
111332,Modify the molecule CC(C)Oc1cccc(/C=C/C(=O)NCc2ccc[nH]2)c1 to have a lower LogP value.,CC(C)Oc1cccc(/C=C/C(=O)NCc2ccc[nH]2)c1,3.131500000000001
91356,Optimize the molecule C#CCN(C(=O)NC1CC1)[C@@H]1CCS(=O)(=O)C1 to have a higher LogP value.,C#CCN(C(=O)NC1CC1)[C@@H]1CCS(=O)(=O)C1,-0.019300000000000095
76536,Modify the molecule C[C@@H](Cn1cc(Br)cn1)N[C@@H]1CCN(C2CCCCC2)C1=O to increase its LogP value.,C[C@@H](Cn1cc(Br)cn1)N[C@@H]1CCN(C2CCCCC2)C1=O,2.5573000000000006
16946,Modify the molecule Cc1cc(N2CCC([NH2+]CCO)CC2)n2c(nc3ccccc32)c1C#N to increase its LogP value.,Cc1cc(N2CCC([NH2+]CCO)CC2)n2c(nc3ccccc32)c1C#N,1.1921000000000006
47522,Please optimize the molecule Cn1ncnc1CNC(=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 to have a lower LogP value.,Cn1ncnc1CNC(=O)C(=O)Nc1ccc(OC(F)(F)F)cc1,0.9686000000000002
183447,Optimize the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(S(=O)(=O)N2CCN(c3nc4ccccc4s3)CC2)cc1 to have a higher LogP value.,CC[C@@H](C)NS(=O)(=O)c1ccc(S(=O)(=O)N2CCN(c3nc4ccccc4s3)CC2)cc1,2.8840000000000012
206956,Optimize the molecule CCN(Cc1cccc(C)c1)C(=O)CNC(=O)Cc1ccccc1 to have a lower LogP value.,CCN(Cc1cccc(C)c1)C(=O)CNC(=O)Cc1ccccc1,2.702420000000001
134776,Please modify the molecule Cc1cc(C)n(-c2nc3c(c(=O)n(CCC(C)C)c(=O)n3C)n2C)n1 to increase its LogP value.,Cc1cc(C)n(-c2nc3c(c(=O)n(CCC(C)C)c(=O)n3C)n2C)n1,1.2823399999999998
54803,Please modify the molecule CC(=O)CSc1ncc2cnccn12 to decrease its LogP value.,CC(=O)CSc1ncc2cnccn12,1.4103999999999999
214895,Optimize the molecule CCc1ccc(Oc2ncnc(Oc3ccccc3)c2N)cc1 to have a lower LogP value.,CCc1ccc(Oc2ncnc(Oc3ccccc3)c2N)cc1,4.205800000000003
28490,Modify the molecule C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O to increase its LogP value.,C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O,2.817100000000001
121622,Please modify the molecule CC[C@H](NC(=O)N1CCCN(c2nccs2)CC1)c1ccc(OC)cc1 to increase its LogP value.,CC[C@H](NC(=O)N1CCCN(c2nccs2)CC1)c1ccc(OC)cc1,3.524700000000003
140444,Modify the molecule CCC1(CC)Nc2c(c(C)nn2C)NC1=O to have a lower LogP value.,CCC1(CC)Nc2c(c(C)nn2C)NC1=O,1.6513199999999997
111117,Optimize the molecule O=C(Nc1nnc(Cc2c[nH]c3ccccc23)s1)c1ccccc1 to have a lower LogP value.,O=C(Nc1nnc(Cc2c[nH]c3ccccc23)s1)c1ccccc1,3.8625000000000016
63564,Modify the molecule CC(C)c1ccc(OCC(=O)N2CCOC23CCCCC3)cc1 to have a lower LogP value.,CC(C)c1ccc(OCC(=O)N2CCOC23CCCCC3)cc1,3.708000000000003
223216,Please optimize the molecule CCCn1c(=O)c2ccccc2n(CC(=O)Nc2ccccc2)c1=O to have a higher LogP value.,CCCn1c(=O)c2ccccc2n(CC(=O)Nc2ccccc2)c1=O,2.2119
169091,Please optimize the molecule CN(C(=O)c1cccc(C(F)(F)F)c1F)c1cccc2ncccc12 to have a lower LogP value.,CN(C(=O)c1cccc(C(F)(F)F)c1F)c1cccc2ncccc12,4.669300000000003
23858,Please modify the molecule Cc1cc(CNC(=O)CCc2nc3ccccc3[nH]2)ccc1F to increase its LogP value.,Cc1cc(CNC(=O)CCc2nc3ccccc3[nH]2)ccc1F,3.2594200000000013
30931,Please modify the molecule C[C@@H]1CCN(C(=O)CCCc2ccccc2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)CCCc2ccccc2)C[C@@H]1O,2.2386000000000004
40516,Optimize the molecule Cc1nc(C)c(C[NH2+][C@@H]2c3ccccc3C[C@H]2C)s1 to have a lower LogP value.,Cc1nc(C)c(C[NH2+][C@@H]2c3ccccc3C[C@H]2C)s1,2.7568400000000013
132823,Modify the molecule O=C(NC[C@@H](CCO)c1ccccc1)c1ccn(-c2ccccc2)n1 to decrease its LogP value.,O=C(NC[C@@H](CCO)c1ccccc1)c1ccn(-c2ccccc2)n1,2.768300000000001
162429,Please optimize the molecule N#C/C(=C\C1=Cc2ccccc2OC1)C(=O)c1cccc2c1OCCO2 to have a lower LogP value.,N#C/C(=C\C1=Cc2ccccc2OC1)C(=O)c1cccc2c1OCCO2,3.566480000000001
67257,Please optimize the molecule C[C@H](Cc1cccs1)N(C)S(=O)(=O)c1cnc(Cl)nc1 to have a lower LogP value.,C[C@H](Cc1cccs1)N(C)S(=O)(=O)c1cnc(Cl)nc1,2.4432
163433,Modify the molecule CCCC(=O)Nc1ccc(CNC(=O)c2ccc(-n3ccnc3)cc2)cc1 to have a higher LogP value.,CCCC(=O)Nc1ccc(CNC(=O)c2ccc(-n3ccnc3)cc2)cc1,3.5409000000000015
66057,Modify the molecule C[C@@H](NC(=O)Nc1ccccc1CS(C)(=O)=O)c1ccc2ccccc2c1 to have a higher LogP value.,C[C@@H](NC(=O)Nc1ccccc1CS(C)(=O)=O)c1ccc2ccccc2c1,4.267100000000004
36530,Modify the molecule Cc1cc(C)nc(SCc2ccccc2C(=O)N2CCN(Cc3ccc(C#N)cc3)CC2)n1 to increase its LogP value.,Cc1cc(C)nc(SCc2ccccc2C(=O)N2CCN(Cc3ccc(C#N)cc3)CC2)n1,4.2154200000000035
118833,Please modify the molecule CCCOc1ccc2ccccc2c1C[NH2+]Cc1ccco1 to increase its LogP value.,CCCOc1ccc2ccccc2c1C[NH2+]Cc1ccco1,3.4852000000000016
78141,Please modify the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1 to increase its LogP value.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1,1.8932000000000004
68533,Modify the molecule COC(=O)c1cc(CNC(=O)N[C@H]2CCC[C@@H](C(F)(F)F)C2)oc1C to decrease its LogP value.,COC(=O)c1cc(CNC(=O)N[C@H]2CCC[C@@H](C(F)(F)F)C2)oc1C,3.294920000000002
192019,Modify the molecule Fc1ccc(-c2nc(COc3ccccc3)co2)cc1 to have a lower LogP value.,Fc1ccc(-c2nc(COc3ccccc3)co2)cc1,4.059700000000002
133626,Please modify the molecule C[C@H]([NH2+]Cc1ccc(Br)cc1)C1CC[NH+](C)CC1 to decrease its LogP value.,C[C@H]([NH2+]Cc1ccc(Br)cc1)C1CC[NH+](C)CC1,0.8256999999999999
143220,Please optimize the molecule COc1cc(NC(=O)[C@H]2CCC[NH+](Cc3ccccc3)C2)ccc1NC(=O)c1cccnc1 to have a higher LogP value.,COc1cc(NC(=O)[C@H]2CCC[NH+](Cc3ccccc3)C2)ccc1NC(=O)c1cccnc1,2.7760999999999996
46306,Please modify the molecule COC(=O)[C@@H](C)O/N=C1\C=C[C@@](C)(C(Cl)(Cl)Cl)C=C1C to decrease its LogP value.,COC(=O)[C@@H](C)O/N=C1\C=C[C@@](C)(C(Cl)(Cl)Cl)C=C1C,3.813100000000003
63671,Modify the molecule O=C(Cn1c(C(=O)c2cccc(F)c2)nc2ccccc21)NCc1ccc(Cl)cc1 to increase its LogP value.,O=C(Cn1c(C(=O)c2cccc(F)c2)nc2ccccc21)NCc1ccc(Cl)cc1,4.376200000000003
84149,Please modify the molecule C#CCNC(=O)c1ccc(NC[C@H]2CCC[NH+](C)C2)nc1 to increase its LogP value.,C#CCNC(=O)c1ccc(NC[C@H]2CCC[NH+](C)C2)nc1,-0.21879999999999833
234677,Optimize the molecule O=c1oc2cccnc2n1CC[NH+]1CCC[C@@H]1c1ccccc1 to have a lower LogP value.,O=c1oc2cccnc2n1CC[NH+]1CCC[C@@H]1c1ccccc1,1.409499999999999
199775,Optimize the molecule CCc1noc(CC)c1CNC(=O)NCC(C)(C)c1cccc(F)c1 to have a lower LogP value.,CCc1noc(CC)c1CNC(=O)NCC(C)(C)c1cccc(F)c1,3.7155000000000022
209435,Optimize the molecule O=[N+]([O-])c1ccc(/C=N/N[C@H]2N=NNN2)s1 to have a lower LogP value.,O=[N+]([O-])c1ccc(/C=N/N[C@H]2N=NNN2)s1,0.33839999999999987
71842,Please modify the molecule C[NH+](C)CCCN1C(=O)C([O-])=C(C(=O)c2ccc3ccccc3c2O)[C@H]1c1ccccc1 to decrease its LogP value.,C[NH+](C)CCCN1C(=O)C([O-])=C(C(=O)c2ccc3ccccc3c2O)[C@H]1c1ccccc1,1.4606000000000012
230055,Modify the molecule NC(=O)c1cc(NC(=O)c2ccc(Cl)c(Cl)c2)c(F)cc1F to have a higher LogP value.,NC(=O)c1cc(NC(=O)c2ccc(Cl)c(Cl)c2)c(F)cc1F,3.6228000000000007
206074,Modify the molecule Cn1nnn([C@@H]2CC(=O)[C@H]3OC[C@@H]2O3)c1=S to have a lower LogP value.,Cn1nnn([C@@H]2CC(=O)[C@H]3OC[C@@H]2O3)c1=S,-0.3985099999999999
203364,Please modify the molecule C#CCN1CCN(S(=O)(=O)CCC2CC2)CC1 to decrease its LogP value.,C#CCN1CCN(S(=O)(=O)CCC2CC2)CC1,0.36709999999999976
124182,Modify the molecule COc1ccc(OC)c(NC(=O)C2=C(C)NC(=O)N[C@@H]2c2ccc(O)cc2)c1 to decrease its LogP value.,COc1ccc(OC)c(NC(=O)C2=C(C)NC(=O)N[C@@H]2c2ccc(O)cc2)c1,2.676
157982,Optimize the molecule COc1ccccc1NC(=O)c1cccc(C)c1OC to have a lower LogP value.,COc1ccccc1NC(=O)c1cccc(C)c1OC,3.264520000000002
147988,Modify the molecule Cc1cc([C@H]2CCCN(C(=O)c3cc(Br)c[nH]3)C2)n[nH]1 to have a higher LogP value.,Cc1cc([C@H]2CCCN(C(=O)c3cc(Br)c[nH]3)C2)n[nH]1,2.82852
193720,Please optimize the molecule Cc1ccc(NC(=O)[C@@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1NC(=O)c1ccc(Cl)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)[C@@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1NC(=O)c1ccc(Cl)cc1,3.027420000000001
248404,Please modify the molecule Nc1cc(N)nc(SCC(=O)Nc2ccc(F)c(F)c2)n1 to increase its LogP value.,Nc1cc(N)nc(SCC(=O)Nc2ccc(F)c(F)c2)n1,1.65
168430,Optimize the molecule [NH3+][C@@H](CO)c1cc(Cl)ccc1Cl to have a higher LogP value.,[NH3+][C@@H](CO)c1cc(Cl)ccc1Cl,1.2687000000000006
80338,Please modify the molecule CC(C)[NH2+]C[C@](C)(O)c1ccccc1 to increase its LogP value.,CC(C)[NH2+]C[C@](C)(O)c1ccccc1,0.8659000000000003
228946,Modify the molecule Cc1ncn(C[C@H](C)[NH2+][C@H](C)C2CCCCC2)c1C to decrease its LogP value.,Cc1ncn(C[C@H](C)[NH2+][C@H](C)C2CCCCC2)c1C,2.4206399999999997
173435,Modify the molecule C[C@H](C[C@@H]1CCCC[NH2+]1)Nc1ccc(OCC#N)cc1 to have a lower LogP value.,C[C@H](C[C@@H]1CCCC[NH2+]1)Nc1ccc(OCC#N)cc1,1.8953799999999992
47676,Modify the molecule Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Cl)cc32)c(C)c1 to decrease its LogP value.,Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Cl)cc32)c(C)c1,3.3938400000000017
33728,Modify the molecule Cn1ccnc1-c1sc(NC(=O)c2ccccc2Br)nc1-c1ccccc1 to have a lower LogP value.,Cn1ccnc1-c1sc(NC(=O)c2ccccc2Br)nc1-c1ccccc1,5.225400000000003
28216,Modify the molecule O=C(CCc1ccsc1)N(C[C@@H]1CCCO1)c1nc2ccccc2s1 to decrease its LogP value.,O=C(CCc1ccsc1)N(C[C@@H]1CCCO1)c1nc2ccccc2s1,4.502600000000004
121865,Please modify the molecule O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1 to decrease its LogP value.,O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1,5.081800000000003
224612,Modify the molecule C[C@@H](Oc1ccccc1C#N)/C([O-])=N/c1nc(C(F)(F)F)n[nH]1 to have a higher LogP value.,C[C@@H](Oc1ccccc1C#N)/C([O-])=N/c1nc(C(F)(F)F)n[nH]1,1.5529799999999998
143647,Optimize the molecule CCC(CC)N(C)C(=O)Nc1ccc2c(c1)CCN2C(C)=O to have a higher LogP value.,CCC(CC)N(C)C(=O)Nc1ccc2c(c1)CCN2C(C)=O,3.2479000000000022
236989,Please optimize the molecule C[C@H](O)[C@H](C)Oc1cc(F)ccc1[C@@H](C)[NH3+] to have a higher LogP value.,C[C@H](O)[C@H](C)Oc1cc(F)ccc1[C@@H](C)[NH3+],1.2767
139062,Please optimize the molecule C[C@H](c1ccncn1)N(C)C(=O)c1csc2nc(-c3ccc(F)cc3)cn12 to have a higher LogP value.,C[C@H](c1ccncn1)N(C)C(=O)c1csc2nc(-c3ccc(F)cc3)cn12,3.8251000000000026
28599,Optimize the molecule Cc1nn(Cc2ccc(C(=O)Nc3cc(C[NH+](C)C)n[nH]3)o2)c(C)c1Br to have a lower LogP value.,Cc1nn(Cc2ccc(C(=O)Nc3cc(C[NH+](C)C)n[nH]3)o2)c(C)c1Br,1.5236399999999999
79159,Please modify the molecule C[C@@H]1CS(=O)(=O)N(c2ccc(S(=O)(=O)N3CCN(c4ncccn4)CC3)cc2)C1=O to decrease its LogP value.,C[C@@H]1CS(=O)(=O)N(c2ccc(S(=O)(=O)N3CCN(c4ncccn4)CC3)cc2)C1=O,0.30000000000000004
80323,Modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2Cl)cc1 to decrease its LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2Cl)cc1,4.419640000000003
12189,Modify the molecule CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O,3.2456000000000023
134629,Modify the molecule COc1ccc(-c2[nH]c3ccccc3c2CCC(=O)N(C)c2ccccc2)cc1 to have a higher LogP value.,COc1ccc(-c2[nH]c3ccccc3c2CCC(=O)N(C)c2ccccc2)cc1,5.439100000000004
166575,Modify the molecule O=C(CSc1nnc(-c2c[nH]c3ccccc23)n1C1CC1)c1ccccc1 to decrease its LogP value.,O=C(CSc1nnc(-c2c[nH]c3ccccc23)n1C1CC1)c1ccccc1,4.7363000000000035
183917,Please modify the molecule [NH3+]C[C@H]1CC[C@H](C(=O)OC[C@H]2CCCO2)O1 to decrease its LogP value.,[NH3+]C[C@H]1CC[C@H](C(=O)OC[C@H]2CCCO2)O1,-0.5018999999999993
32357,Please optimize the molecule Cc1ncsc1CN1CCN(Cc2scnc2C)CC1 to have a higher LogP value.,Cc1ncsc1CN1CCN(Cc2scnc2C)CC1,2.5342400000000005
3284,Optimize the molecule CCc1ccsc1CNC(=O)C(=O)Nc1cc(F)cc(F)c1 to have a higher LogP value.,CCc1ccsc1CNC(=O)C(=O)Nc1cc(F)cc(F)c1,2.8436000000000003
173058,Optimize the molecule CC(=O)N[C@H]1CCCN(C(=O)c2cccc[n+]2[O-])C1 to have a higher LogP value.,CC(=O)N[C@H]1CCCN(C(=O)c2cccc[n+]2[O-])C1,0.0607000000000002
67106,Please optimize the molecule [NH3+][C@H](Cc1ccccc1Br)[C@@H]1CCOC2(CCOCC2)C1 to have a higher LogP value.,[NH3+][C@H](Cc1ccccc1Br)[C@@H]1CCOC2(CCOCC2)C1,2.5779000000000005
71552,Modify the molecule COCc1cc(C(=O)N(C)Cc2nnc(C3CC3)n2C)ccc1F to have a higher LogP value.,COCc1cc(C(=O)N(C)Cc2nnc(C3CC3)n2C)ccc1F,2.2502000000000004
184970,Modify the molecule O=C(c1cc(Cl)ccc1[N+](=O)[O-])N1CCCc2cc(F)ccc21 to have a lower LogP value.,O=C(c1cc(Cl)ccc1[N+](=O)[O-])N1CCCc2cc(F)ccc21,3.9803000000000024
109017,Modify the molecule COc1ccccc1/C=C/C(=O)Nc1cc(N2CCOC2=O)ccc1C to have a higher LogP value.,COc1ccccc1/C=C/C(=O)Nc1cc(N2CCOC2=O)ccc1C,3.6121200000000018
223488,Optimize the molecule Cc1cc(OC(C)(C)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1Cl to have a lower LogP value.,Cc1cc(OC(C)(C)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1Cl,3.4895200000000024
238226,Modify the molecule C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccc2c(c1)NC(=O)CO2 to have a higher LogP value.,C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccc2c(c1)NC(=O)CO2,3.3465000000000016
54724,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])cc1)c1ccco1 to have a higher LogP value.,O=C(Nc1ccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])cc1)c1ccco1,2.0267
7685,Please optimize the molecule CC(C)(C)c1cc(C(=O)[C@H](C#N)c2nc3cc(Cl)ccc3s2)[nH]n1 to have a higher LogP value.,CC(C)(C)c1cc(C(=O)[C@H](C#N)c2nc3cc(Cl)ccc3s2)[nH]n1,4.4603800000000025
22904,Please optimize the molecule Cc1oc(-c2cccs2)nc1COc1nnc(-c2ccccc2)o1 to have a higher LogP value.,Cc1oc(-c2cccs2)nc1COc1nnc(-c2ccccc2)o1,4.340520000000003
112774,Modify the molecule NC(=S)[C@@H]1CN(c2snc3ccccc23)CCO1 to increase its LogP value.,NC(=S)[C@@H]1CN(c2snc3ccccc23)CCO1,1.7876
172198,Optimize the molecule CC[NH+](C)Cc1ccc(C(=O)NCc2cnc3ccccc3c2)c(=O)[nH]1 to have a lower LogP value.,CC[NH+](C)Cc1ccc(C(=O)NCc2cnc3ccccc3c2)c(=O)[nH]1,0.8876999999999999
76248,Please optimize the molecule O=C(c1ccc2cc[nH]c2c1)N(C[C@@H]1CCCO1)[C@H]1CCS(=O)(=O)C1 to have a lower LogP value.,O=C(c1ccc2cc[nH]c2c1)N(C[C@@H]1CCCO1)[C@H]1CCS(=O)(=O)C1,1.9762
130862,Please optimize the molecule CCn1nc(C)c2c1c(=O)n(Cc1ccccc1)c(=O)n2CC(N)=O to have a higher LogP value.,CCn1nc(C)c2c1c(=O)n(Cc1ccccc1)c(=O)n2CC(N)=O,0.22162000000000004
2600,Please modify the molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 to decrease its LogP value.,CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1,2.4893
182711,Please modify the molecule O=C(NCc1csc(C2CC2)n1)N[C@H]1C[C@H]1c1cccc(Cl)c1 to decrease its LogP value.,O=C(NCc1csc(C2CC2)n1)N[C@H]1C[C@H]1c1cccc(Cl)c1,4.029200000000003
7251,Modify the molecule Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1 to increase its LogP value.,Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1,1.5155799999999993
237602,Modify the molecule c1ccc(N[C@@H]2CCC[NH+](Cc3ccc(N4CCCC4)nc3)C2)cc1 to have a lower LogP value.,c1ccc(N[C@@H]2CCC[NH+](Cc3ccc(N4CCCC4)nc3)C2)cc1,2.3411999999999997
182848,Please optimize the molecule COc1ccc(F)cc1S(=O)(=O)NCCc1c(C)[nH]c2c(Cl)cccc12 to have a higher LogP value.,COc1ccc(F)cc1S(=O)(=O)NCCc1c(C)[nH]c2c(Cl)cccc12,3.798420000000002
171234,Optimize the molecule O=C(Nc1ccc(F)c(Cl)c1)C1CCN(C(=O)Cn2ccnc2)CC1 to have a lower LogP value.,O=C(Nc1ccc(F)c(Cl)c1)C1CCN(C(=O)Cn2ccnc2)CC1,2.552900000000001
90042,Please optimize the molecule COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1 to have a higher LogP value.,COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1,2.5672200000000007
130546,Optimize the molecule CCN1CCO[C@H](c2noc(-c3n[nH]c(N)n3)n2)C1 to have a higher LogP value.,CCN1CCO[C@H](c2noc(-c3n[nH]c(N)n3)n2)C1,-0.16990000000000055
77549,Optimize the molecule CC1=C(C(=O)Nc2ccc(C)cc2)[C@H](c2cccc3ccccc23)n2ncnc2N1 to have a higher LogP value.,CC1=C(C(=O)Nc2ccc(C)cc2)[C@H](c2cccc3ccccc23)n2ncnc2N1,4.667320000000004
241513,Optimize the molecule COc1ccc(F)c(CN(Cc2sccc2C)C[C@H](C)O)c1 to have a higher LogP value.,COc1ccc(F)c(CN(Cc2sccc2C)C[C@H](C)O)c1,3.587220000000003
54193,Please optimize the molecule O=S(=O)(N1CCCC1)N1CCN(Cc2nnsc2Cl)CC1 to have a higher LogP value.,O=S(=O)(N1CCCC1)N1CCN(Cc2nnsc2Cl)CC1,0.6496999999999999
129581,Modify the molecule C[C@@H](Oc1ccccc1[N+](=O)[O-])C(=O)Nc1ccc2ccccc2c1 to have a lower LogP value.,C[C@@H](Oc1ccccc1[N+](=O)[O-])C(=O)Nc1ccc2ccccc2c1,4.154000000000003
183947,Optimize the molecule Cc1cscc1C(=O)Nc1cc(Cl)ccc1N to have a higher LogP value.,Cc1cscc1C(=O)Nc1cc(Cl)ccc1N,3.5444200000000015
231778,Please modify the molecule C=C(C)[C@@H](NC)c1[nH+]ccc2ccccc12 to increase its LogP value.,C=C(C)[C@@H](NC)c1[nH+]ccc2ccccc12,2.4905
237952,Modify the molecule O=S(=O)(NCC[C@@H](O)C1CC1)C1CC1 to decrease its LogP value.,O=S(=O)(NCC[C@@H](O)C1CC1)C1CC1,0.2291999999999994
237926,Optimize the molecule CN(C(=O)c1cc2ccccc2s1)[C@@H]1CCC[NH+](CCc2ccccc2)C1 to have a lower LogP value.,CN(C(=O)c1cc2ccccc2s1)[C@@H]1CCC[NH+](CCc2ccccc2)C1,3.263300000000002
108854,Modify the molecule O=C1NC(=O)C(=C/C=C/c2coc3ccccc3c2=O)C(=O)N1 to have a higher LogP value.,O=C1NC(=O)C(=C/C=C/c2coc3ccccc3c2=O)C(=O)N1,1.0985999999999998
134536,Modify the molecule C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ncccc1CCl to decrease its LogP value.,C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ncccc1CCl,1.4662999999999997
123943,Modify the molecule CN(C[C@@H](O)C1CC1)C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,CN(C[C@@H](O)C1CC1)C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1,3.326200000000002
213925,Optimize the molecule COC(=O)[C@H](C)C[NH2+]Cc1ccccn1 to have a lower LogP value.,COC(=O)[C@H](C)C[NH2+]Cc1ccccn1,-0.04589999999999983
150702,Please modify the molecule COC[C@@H](NC(=O)c1ccccc1C(=O)c1ccc(F)cc1)C(N)=O to increase its LogP value.,COC[C@@H](NC(=O)c1ccccc1C(=O)c1ccc(F)cc1)C(N)=O,1.2868
1751,Please modify the molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 to decrease its LogP value.,O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1,0.9917000000000004
123406,Modify the molecule NC(=O)c1ccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)OCC(F)(F)F)cc1 to have a lower LogP value.,NC(=O)c1ccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)OCC(F)(F)F)cc1,2.6359000000000004
169355,Modify the molecule CC(C)[C@@H](Cc1ccc(F)cc1)NC(=O)C(=O)Nc1ccc(N(C)C)nc1 to decrease its LogP value.,CC(C)[C@@H](Cc1ccc(F)cc1)NC(=O)C(=O)Nc1ccc(N(C)C)nc1,2.6087000000000007
168313,Modify the molecule CC(C)C[NH+]1CCN([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1 to decrease its LogP value.,CC(C)C[NH+]1CCN([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1,0.7417800000000014
220470,Please optimize the molecule CN(C)C(=O)Cn1cc(C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)nn1 to have a lower LogP value.,CN(C)C(=O)Cn1cc(C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)nn1,-1.8382999999999963
127117,Please modify the molecule CCOC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)Oc2ccc(F)cc2F)c1C to increase its LogP value.,CCOC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)Oc2ccc(F)cc2F)c1C,3.736640000000003
60279,Please optimize the molecule C[C@H]1CCCC[C@]1(NC(=O)N1CCC[C@@H](C)C1)C(=O)[O-] to have a lower LogP value.,C[C@H]1CCCC[C@]1(NC(=O)N1CCC[C@@H](C)C1)C(=O)[O-],1.1267
35576,Modify the molecule CC[C@H]1CCCCN1C(=O)[C@@H](C)OC(=O)c1cncc(C)c1 to have a higher LogP value.,CC[C@H]1CCCCN1C(=O)[C@@H](C)OC(=O)c1cncc(C)c1,2.726420000000001
168030,Modify the molecule Cc1ccc(CNC(=O)N[C@H](C)[C@H](C)N2CCOCC2)c(N(C)C)c1 to have a higher LogP value.,Cc1ccc(CNC(=O)N[C@H](C)[C@H](C)N2CCOCC2)c(N(C)C)c1,1.9694200000000002
196214,Modify the molecule C[C@@H](OC(=O)C(C)(C)c1cccc(Cl)c1)c1ccccn1 to increase its LogP value.,C[C@@H](OC(=O)C(C)(C)c1cccc(Cl)c1)c1ccccn1,4.317000000000004
99413,Modify the molecule CC[C@@H](NC(=O)COc1ccc2c(c1)CCC(=O)N2)c1ccc(OC)cc1 to have a higher LogP value.,CC[C@@H](NC(=O)COc1ccc2c(c1)CCC(=O)N2)c1ccc(OC)cc1,3.2262000000000013
22846,Please modify the molecule CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1 to decrease its LogP value.,CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1,2.4691
240104,Please optimize the molecule O=C1O[C@@H](N2CCN(Cc3ccccc3)CC2)c2ccccc21 to have a lower LogP value.,O=C1O[C@@H](N2CCN(Cc3ccccc3)CC2)c2ccccc21,2.673400000000001
111151,Please modify the molecule OCC[C@H](CNc1ncnc2cccc(F)c12)c1ccccc1 to increase its LogP value.,OCC[C@H](CNc1ncnc2cccc(F)c12)c1ccccc1,3.3470000000000013
6074,Modify the molecule CCCCN1C(=O)S[C@H](Nc2cccc(C(F)(F)F)c2)C1=O to have a lower LogP value.,CCCCN1C(=O)S[C@H](Nc2cccc(C(F)(F)F)c2)C1=O,3.938900000000003
145248,Please modify the molecule COc1ccc(CN2CCC[C@@H](c3cc(=O)[nH]c(-c4ccncc4)n3)C2)c(OC)c1OC to increase its LogP value.,COc1ccc(CN2CCC[C@@H](c3cc(=O)[nH]c(-c4ccncc4)n3)C2)c(OC)c1OC,3.237300000000002
31427,Please modify the molecule O=C(Nc1ccccc1OCC(F)(F)F)c1c[nH]c2cccc(F)c12 to increase its LogP value.,O=C(Nc1ccccc1OCC(F)(F)F)c1c[nH]c2cccc(F)c12,4.500400000000002
61135,Optimize the molecule O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12 to have a higher LogP value.,O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12,1.1765999999999999
214748,Optimize the molecule Cc1onc(-c2ccccc2Cl)c1C1=NCCO1 to have a lower LogP value.,Cc1onc(-c2ccccc2Cl)c1C1=NCCO1,3.0802200000000024
56141,Please optimize the molecule Cc1ccc([C@@H](C)NC(=O)NCc2cc[nH+]c(N3CCOCC3)c2)o1 to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)NCc2cc[nH+]c(N3CCOCC3)c2)o1,1.7991199999999998
13664,Modify the molecule Cc1nc(-c2ccc(OS(=O)(=O)c3ccccc3-c3ccccc3)cc2)no1 to increase its LogP value.,Cc1nc(-c2ccc(OS(=O)(=O)c3ccccc3-c3ccccc3)cc2)no1,4.479720000000004
61683,Please modify the molecule COc1cc(CN2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)c([N+](=O)[O-])cc1O to decrease its LogP value.,COc1cc(CN2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)c([N+](=O)[O-])cc1O,3.675000000000003
102439,Modify the molecule Cc1cccc(OCC[NH2+]Cc2nc3ccccc3n2C)c1 to have a higher LogP value.,Cc1cccc(OCC[NH2+]Cc2nc3ccccc3n2C)c1,2.0241199999999995
101494,Modify the molecule CCN1C(=O)N[C@@H](c2cccc(F)c2)[C@@H]2C(=O)CC(C)(C)C[C@@]21O to have a lower LogP value.,CCN1C(=O)N[C@@H](c2cccc(F)c2)[C@@H]2C(=O)CC(C)(C)C[C@@]21O,2.6058000000000017
83775,Optimize the molecule Cc1nc(CCC(=O)N2C[C@@H](C[NH+]3CCCCCC3)[C@@H](CO)C2)n[nH]1 to have a lower LogP value.,Cc1nc(CCC(=O)N2C[C@@H](C[NH+]3CCCCCC3)[C@@H](CO)C2)n[nH]1,-0.4284799999999968
23276,Optimize the molecule CCc1cccc(NC(=O)CN2C(=O)C(C)(C)c3cc(S(=O)(=O)N4CCCC4)ccc32)c1 to have a higher LogP value.,CCc1cccc(NC(=O)CN2C(=O)C(C)(C)c3cc(S(=O)(=O)N4CCCC4)ccc32)c1,3.296400000000001
49831,Please modify the molecule C[NH+](C1CCSCC1)[C@H]1CCN(c2ccccc2)C1=O to increase its LogP value.,C[NH+](C1CCSCC1)[C@H]1CCN(c2ccccc2)C1=O,1.2022
134406,Please modify the molecule N#Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CCCC[C@@H]1O to increase its LogP value.,N#Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CCCC[C@@H]1O,2.181880000000001
222861,Modify the molecule CCO[C@H]1CCCN(C(=O)NCc2ccnc(OCc3ccccc3)c2)C1 to decrease its LogP value.,CCO[C@H]1CCCN(C(=O)NCc2ccnc(OCc3ccccc3)c2)C1,3.371100000000002
143347,Modify the molecule Cc1cnc(CN2CCc3cnc(C)nc3C2)cn1 to increase its LogP value.,Cc1cnc(CN2CCc3cnc(C)nc3C2)cn1,1.44174
192233,Please optimize the molecule Cc1ccc(F)c(S(=O)(=O)NCc2cscn2)c1 to have a higher LogP value.,Cc1ccc(F)c(S(=O)(=O)NCc2cscn2)c1,2.06912
178730,Please modify the molecule O=C(CSc1ccc(Cl)cc1)Nc1ccc([N+](=O)[O-])cc1N1CCOCC1 to increase its LogP value.,O=C(CSc1ccc(Cl)cc1)Nc1ccc([N+](=O)[O-])cc1N1CCOCC1,3.8156000000000025
201929,Please optimize the molecule Cn1cc(C[NH+]2CCC[C@@H]2CC(C)(C)C)c(-c2ccncc2)n1 to have a lower LogP value.,Cn1cc(C[NH+]2CCC[C@@H]2CC(C)(C)C)c(-c2ccncc2)n1,2.4656000000000002
12032,Please modify the molecule CCc1onc(C)c1NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)CC to decrease its LogP value.,CCc1onc(C)c1NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)CC,3.483520000000002
87986,Modify the molecule Fc1ccc(/C=C/C[NH+]2CCC[C@@H](c3cn[nH]c3)C2)cc1 to have a higher LogP value.,Fc1ccc(/C=C/C[NH+]2CCC[C@@H](c3cn[nH]c3)C2)cc1,2.0244999999999997
63541,Optimize the molecule C[C@@H]1C[NH+](C)CC[C@@H]1NC(=O)CCc1ccccc1 to have a lower LogP value.,C[C@@H]1C[NH+](C)CC[C@@H]1NC(=O)CCc1ccccc1,0.6585000000000012
79907,Please modify the molecule C[C@@H](CCO)Sc1cccnn1 to increase its LogP value.,C[C@@H](CCO)Sc1cccnn1,1.3396
75632,Optimize the molecule O=C(CNC(=O)c1ccc2sncc2c1)NCC1CCCCC1 to have a lower LogP value.,O=C(CNC(=O)c1ccc2sncc2c1)NCC1CCCCC1,2.722600000000001
116947,Optimize the molecule CCCNC(=O)Nc1cc2c(cc1OCC)C[C@@H](C)O2 to have a higher LogP value.,CCCNC(=O)Nc1cc2c(cc1OCC)C[C@@H](C)O2,2.940200000000001
15774,Optimize the molecule CCn1c(SCC(N)=O)nnc1-c1ccc(Cl)cc1 to have a lower LogP value.,CCn1c(SCC(N)=O)nnc1-c1ccc(Cl)cc1,2.1958
140766,Optimize the molecule C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCN(c2ccccc2Cl)CC1 to have a lower LogP value.,C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCN(c2ccccc2Cl)CC1,3.898500000000003
91701,Modify the molecule COc1ccc(CNS(=O)(=O)Cc2ccccc2)cc1 to have a higher LogP value.,COc1ccc(CNS(=O)(=O)Cc2ccccc2)cc1,2.3148
37696,Modify the molecule Cc1cccc(COC(=O)Cn2c(=O)sc3cccc(Cl)c32)c1 to have a higher LogP value.,Cc1cccc(COC(=O)Cn2c(=O)sc3cccc(Cl)c32)c1,3.768220000000003
221833,Optimize the molecule O=C1/C(=C\c2cccc(O)c2)SC(=S)N1c1cccc2ccccc12 to have a lower LogP value.,O=C1/C(=C\c2cccc(O)c2)SC(=S)N1c1cccc2ccccc12,4.951200000000003
25906,Optimize the molecule CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccccc5Cl)no4)cnc32)cc1 to have a higher LogP value.,CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccccc5Cl)no4)cnc32)cc1,3.127600000000001
119070,Please optimize the molecule COC[C@H](C)NC(=O)C[NH+](C)CCO to have a higher LogP value.,COC[C@H](C)NC(=O)C[NH+](C)CCO,-2.355499999999996
210468,Please optimize the molecule Cc1ccccc1CC(=O)Nc1ccc(SCc2nc3ccccc3[nH]c2=O)cc1 to have a lower LogP value.,Cc1ccccc1CC(=O)Nc1ccc(SCc2nc3ccccc3[nH]c2=O)cc1,4.705020000000004
192648,Please modify the molecule CC(C)(C)C(=O)NC[C@H]1CCCN(C(=O)[C@H]2SCCc3ccccc32)C1 to decrease its LogP value.,CC(C)(C)C(=O)NC[C@H]1CCCN(C(=O)[C@H]2SCCc3ccccc32)C1,3.417900000000002
225220,Optimize the molecule COc1ccc(OC)c([C@@H]2CC(=O)NC3=NC(SC)=NC(=O)[C@@H]32)c1 to have a higher LogP value.,COc1ccc(OC)c([C@@H]2CC(=O)NC3=NC(SC)=NC(=O)[C@@H]32)c1,1.5812
127128,Please modify the molecule CCN(C(=O)CSc1nncn1-c1ccccc1C)C1CCCCC1 to decrease its LogP value.,CCN(C(=O)CSc1nncn1-c1ccccc1C)C1CCCCC1,3.849020000000003
125752,Modify the molecule C[NH+]1CCN(c2cc(CNC(=O)NCc3cccs3)cc[nH+]2)CC1 to decrease its LogP value.,C[NH+]1CCN(c2cc(CNC(=O)NCc3cccs3)cc[nH+]2)CC1,-0.10369999999999702
98596,Modify the molecule Cc1ccc(NC(=O)N2CCC(c3nnc(C(=O)Nc4ccccc4)s3)CC2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)N2CCC(c3nnc(C(=O)Nc4ccccc4)s3)CC2)cc1,4.510320000000003
180875,Please optimize the molecule CCc1ccsc1CNc1cc(F)ccc1[N+](=O)[O-] to have a higher LogP value.,CCc1ccsc1CNc1cc(F)ccc1[N+](=O)[O-],3.9699000000000026
17345,Please modify the molecule COc1ccc([C@H]2CC(=O)C3=C(C2)OC(N)=C(C#N)[C@@H]3c2ccc(Cl)cc2)cc1 to decrease its LogP value.,COc1ccc([C@H]2CC(=O)C3=C(C2)OC(N)=C(C#N)[C@@H]3c2ccc(Cl)cc2)cc1,4.557080000000004
13506,Please optimize the molecule CC(C)[C@@H]([NH2+][C@@H]1CSCC(C)(C)C1)C(=O)[O-] to have a lower LogP value.,CC(C)[C@@H]([NH2+][C@@H]1CSCC(C)(C)C1)C(=O)[O-],-0.14399999999999857
188374,Please modify the molecule CCC(=O)NC(=S)NNC(=O)Cc1ccccc1 to decrease its LogP value.,CCC(=O)NC(=S)NNC(=O)Cc1ccccc1,0.6609999999999997
22738,Please modify the molecule O=C(c1ccccc1[N+](=O)[O-])N(CCC(F)(F)F)C1CCCCC1 to increase its LogP value.,O=C(c1ccccc1[N+](=O)[O-])N(CCC(F)(F)F)C1CCCCC1,4.322100000000003
214937,Please optimize the molecule c1ccc2c(c1)C[C@@H](CN1CCC[C@@H]1[C@@H]1CCC[NH2+]1)S2 to have a higher LogP value.,c1ccc2c(c1)C[C@@H](CN1CCC[C@@H]1[C@@H]1CCC[NH2+]1)S2,1.8936
196215,Modify the molecule CCCCN1C[C@@H](C(=O)N(CC)CC)CC1=O to increase its LogP value.,CCCCN1C[C@@H](C(=O)N(CC)CC)CC1=O,1.5033999999999998
85700,Optimize the molecule O=C(Cn1cnc2ccccc21)Nc1ccc(Oc2ccccc2)cc1 to have a higher LogP value.,O=C(Cn1cnc2ccccc21)Nc1ccc(Oc2ccccc2)cc1,4.4673000000000025
216565,Optimize the molecule COc1ccc(-c2cc3nccc(-c4cc(O)ccc4O)n3n2)cc1 to have a higher LogP value.,COc1ccc(-c2cc3nccc(-c4cc(O)ccc4O)n3n2)cc1,3.483100000000002
77547,Please optimize the molecule COc1ccc(Cl)cc1N1C[C@H](C(=O)NCc2cccs2)CC1=O to have a lower LogP value.,COc1ccc(Cl)cc1N1C[C@H](C(=O)NCc2cccs2)CC1=O,3.0794000000000006
164850,Please optimize the molecule COc1ccccc1N(C)C(=O)c1cc2c([nH]c1=O)CCCC2 to have a lower LogP value.,COc1ccccc1N(C)C(=O)c1cc2c([nH]c1=O)CCCC2,2.538900000000001
113915,Please optimize the molecule Cc1ccc(NC(=O)C[NH+](C)Cc2cc(C)on2)c([N+](=O)[O-])c1 to have a higher LogP value.,Cc1ccc(NC(=O)C[NH+](C)Cc2cc(C)on2)c([N+](=O)[O-])c1,0.8530400000000005
211382,Modify the molecule CC(C)n1ccnc1[C@H](C)Br to decrease its LogP value.,CC(C)n1ccnc1[C@H](C)Br,2.919900000000001
180700,Please modify the molecule Cc1nn([C@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)Nc1nc2c(C)cccc2s1 to increase its LogP value.,Cc1nn([C@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)Nc1nc2c(C)cccc2s1,2.9588600000000014
68778,Modify the molecule Cc1c([C@@H]2C[C@H](Cl)CCO2)cnn1C to have a lower LogP value.,Cc1c([C@@H]2C[C@H](Cl)CCO2)cnn1C,2.1874199999999995
74481,Modify the molecule Cc1cccc(CSC2=NCCN2C(=O)[C@H](C)Oc2ccccc2)c1 to have a lower LogP value.,Cc1cccc(CSC2=NCCN2C(=O)[C@H](C)Oc2ccccc2)c1,3.893920000000003
82794,Modify the molecule CCC[C@@H](C[NH3+])[C@H](O)c1sccc1CC to have a higher LogP value.,CCC[C@@H](C[NH3+])[C@H](O)c1sccc1CC,2.0021
209235,Please modify the molecule Nc1ccc(Br)c(N)c1Br to increase its LogP value.,Nc1ccc(Br)c(N)c1Br,2.3760000000000003
59416,Modify the molecule O=C(NCCc1nnc(-c2ccccc2)o1)[C@@H]1CCCc2ccccc21 to have a higher LogP value.,O=C(NCCc1nnc(-c2ccccc2)o1)[C@@H]1CCCc2ccccc21,3.5154000000000023
141486,Optimize the molecule COC(=O)Cn1/c(=N/C(=O)c2cc3ccccc3oc2=O)sc2cc(C)ccc21 to have a lower LogP value.,COC(=O)Cn1/c(=N/C(=O)c2cc3ccccc3oc2=O)sc2cc(C)ccc21,3.031720000000001
22737,Modify the molecule COc1ccc(C(=O)N/N=C2/C(=O)N(CN3CCCC3)c3ccc(Br)cc32)cc1 to increase its LogP value.,COc1ccc(C(=O)N/N=C2/C(=O)N(CN3CCCC3)c3ccc(Br)cc32)cc1,2.9917000000000016
145719,Modify the molecule C[C@H]1CN(C(=O)Cl)[C@H](C)CO1 to increase its LogP value.,C[C@H]1CN(C(=O)Cl)[C@H](C)CO1,1.4544000000000001
117548,Please optimize the molecule O=C1CCN(c2cccc(Cl)c2F)C(=O)C1 to have a higher LogP value.,O=C1CCN(c2cccc(Cl)c2F)C(=O)C1,2.175
153593,Modify the molecule CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(Cl)cccc3s2)cc1 to have a higher LogP value.,CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(Cl)cccc3s2)cc1,4.985300000000004
70084,Modify the molecule Cc1c(NC(=O)c2ccc([N+](=O)[O-])cc2F)cccc1C(N)=O to decrease its LogP value.,Cc1c(NC(=O)c2ccc([N+](=O)[O-])cc2F)cccc1C(N)=O,2.3935199999999996
102415,Please modify the molecule COc1cc(C[NH2+][C@H](CO)c2ccc(Cl)cc2)cc2c1OCO2 to increase its LogP value.,COc1cc(C[NH2+][C@H](CO)c2ccc(Cl)cc2)cc2c1OCO2,1.8743
81196,Modify the molecule COc1nc(C)cc(=O)n1CCC[NH2+]C(C)C to have a lower LogP value.,COc1nc(C)cc(=O)n1CCC[NH2+]C(C)C,-0.07777999999999907
15618,Modify the molecule O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2cc(-c3ccccn3)[nH]n2)C1 to increase its LogP value.,O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2cc(-c3ccccn3)[nH]n2)C1,2.3827
241325,Please modify the molecule Cc1nc(-c2ccccc2)c(C(=O)N(C)Cc2nc3ccccc3[nH]2)s1 to decrease its LogP value.,Cc1nc(-c2ccccc2)c(C(=O)N(C)Cc2nc3ccccc3[nH]2)s1,4.267020000000003
91322,Please modify the molecule O=C(CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1)Nc1cccc(Cl)c1Cl to increase its LogP value.,O=C(CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1)Nc1cccc(Cl)c1Cl,4.979900000000004
193335,Modify the molecule C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1 to increase its LogP value.,C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1,3.2390000000000008
114576,Please optimize the molecule Cc1cccc([C@H](O)c2cccc(C3CC3)c2)c1C to have a higher LogP value.,Cc1cccc([C@H](O)c2cccc(C3CC3)c2)c1C,4.262540000000003
246352,Please optimize the molecule CS(=O)(=O)N1CCC[C@@H](Cc2ccnc(Cl)c2)CC1 to have a higher LogP value.,CS(=O)(=O)N1CCC[C@@H](Cc2ccnc(Cl)c2)CC1,2.3392
99010,Optimize the molecule O=C(NCCC[NH+]1CCCCC1)N1CCCCCCC1 to have a higher LogP value.,O=C(NCCC[NH+]1CCCCC1)N1CCCCCCC1,1.4209999999999996
183796,Optimize the molecule Cn1nc(C(=O)OCC(=O)N2CCC(c3ccccc3)=N2)c2ccccc2c1=O to have a higher LogP value.,Cn1nc(C(=O)OCC(=O)N2CCC(c3ccccc3)=N2)c2ccccc2c1=O,1.7268999999999999
75665,Modify the molecule O=C(NC[C@H]1CN2CCCC[C@@H]2CO1)N1CCC(n2cccn2)CC1 to have a higher LogP value.,O=C(NC[C@H]1CN2CCCC[C@@H]2CO1)N1CCC(n2cccn2)CC1,1.482899999999999
21065,Please optimize the molecule CC(=O)[C@@H]1CC[C@@H]([NH2+]C2CCC([N+](=O)[O-])CC2)[C@H]([N+](=O)[O-])C1 to have a lower LogP value.,CC(=O)[C@@H]1CC[C@@H]([NH2+]C2CCC([N+](=O)[O-])CC2)[C@H]([N+](=O)[O-])C1,0.5407000000000015
234555,Please modify the molecule CC[C@H]1CCN(c2cc(OC)ccc2F)CC[C@H](C)[NH2+]1 to increase its LogP value.,CC[C@H]1CCN(c2cc(OC)ccc2F)CC[C@H](C)[NH2+]1,2.165
216300,Optimize the molecule Cc1ccc(C=C2C(=O)OC3(CCCC3)OC2=O)cc1Br to have a lower LogP value.,Cc1ccc(C=C2C(=O)OC3(CCCC3)OC2=O)cc1Br,3.5112200000000025
57559,Optimize the molecule CC(C)CC(=O)Nc1ccc(Cl)c(C(=O)N(C)C2CCOCC2)c1 to have a higher LogP value.,CC(C)CC(=O)Nc1ccc(Cl)c(C(=O)N(C)C2CCOCC2)c1,3.5756000000000023
92009,Optimize the molecule C[C@H]1CCC[C@@](CNC(=O)C[C@H](O)c2cccc(F)c2)([NH+](C)C)C1 to have a lower LogP value.,C[C@H]1CCC[C@@](CNC(=O)C[C@H](O)c2cccc(F)c2)([NH+](C)C)C1,1.4588
36424,Please modify the molecule Cc1ccc(Cl)c(NC(=O)C[NH+]2CCC[C@H]2C(=O)[O-])c1Cl to decrease its LogP value.,Cc1ccc(Cl)c(NC(=O)C[NH+]2CCC[C@H]2C(=O)[O-])c1Cl,0.03751999999999933
211146,Modify the molecule CS(=O)(=O)c1cnc(-c2ccncc2)nc1[C@@H]1CCCN(C(=O)C2CCCC2)C1 to decrease its LogP value.,CS(=O)(=O)c1cnc(-c2ccncc2)nc1[C@@H]1CCCN(C(=O)C2CCCC2)C1,2.838300000000001
8001,Please modify the molecule C=CC(=O)N[C@@H](OC)C(=O)OC to increase its LogP value.,C=CC(=O)N[C@@H](OC)C(=O)OC,-0.5659000000000001
58157,Modify the molecule CN(C[C@H](O)CN1CC[NH+](C)CC1)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl to have a lower LogP value.,CN(C[C@H](O)CN1CC[NH+](C)CC1)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl,-0.09689999999999704
231156,Please modify the molecule CC[C@@H](OC(=O)[C@@H](C)C1CCOCC1)c1cc(C)ccc1OC to decrease its LogP value.,CC[C@@H](OC(=O)[C@@H](C)C1CCOCC1)c1cc(C)ccc1OC,4.060620000000004
93668,Optimize the molecule COC(=O)[C@@H]1C(=O)C2=C(CC1(C)C)N1CCc3ccccc3[C@@H]1CC2=O to have a lower LogP value.,COC(=O)[C@@H]1C(=O)C2=C(CC1(C)C)N1CCc3ccccc3[C@@H]1CC2=O,2.600900000000001
134740,Optimize the molecule COCCCN1CC2(CCN(C(=O)CCn3nnnc3C)CC2)CC1=O to have a lower LogP value.,COCCCN1CC2(CCN(C(=O)CCn3nnnc3C)CC2)CC1=O,0.24922000000000133
140138,Optimize the molecule Cc1cccc(C)c1OCC(=O)NNC(=S)NC(=O)c1ccccc1F to have a lower LogP value.,Cc1cccc(C)c1OCC(=O)NNC(=S)NC(=O)c1ccccc1F,2.1570399999999994
59694,Please optimize the molecule C[C@@H](O)[C@@H](NC(=O)Nc1ccc(F)cc1F)C(=O)[O-] to have a higher LogP value.,C[C@@H](O)[C@@H](NC(=O)Nc1ccc(F)cc1F)C(=O)[O-],-0.4144000000000003
124291,Modify the molecule O=C1CCC[C@H]1[C@H]1CCCC[NH+]1CCC(F)(F)F to have a higher LogP value.,O=C1CCC[C@H]1[C@H]1CCCC[NH+]1CCC(F)(F)F,1.7454
220071,Modify the molecule CN1CCO[C@@H](C[NH+](C)C2CCC([NH3+])CC2)C1 to decrease its LogP value.,CN1CCO[C@@H](C[NH+](C)C2CCC([NH3+])CC2)C1,-1.6151999999999962
68956,Please modify the molecule O=C(Nc1nc(-c2cc3ccccc3oc2=O)cs1)c1c[nH]c2ccccc12 to decrease its LogP value.,O=C(Nc1nc(-c2cc3ccccc3oc2=O)cs1)c1c[nH]c2ccccc12,4.650100000000003
54825,Modify the molecule Cc1noc(C)c1CC(=O)O[C@@H](C)Cn1cccn1 to increase its LogP value.,Cc1noc(C)c1CC(=O)O[C@@H](C)Cn1cccn1,1.66234
5756,Please optimize the molecule CN(C)c1cccc(C(=O)N(Cc2ccsc2)C2CC2)c1 to have a higher LogP value.,CN(C)c1cccc(C(=O)N(Cc2ccsc2)C2CC2)c1,3.6189000000000027
60369,Modify the molecule COc1cc([C@@H]2CC(=O)Nc3nc(C)[nH]c(=O)c32)ccc1OCc1ccccc1F to decrease its LogP value.,COc1cc([C@@H]2CC(=O)Nc3nc(C)[nH]c(=O)c32)ccc1OCc1ccccc1F,3.2791200000000016
189795,Optimize the molecule Cc1ccc(CCNC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c(C)c1 to have a higher LogP value.,Cc1ccc(CCNC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c(C)c1,3.219140000000002
227806,Optimize the molecule COC(=O)[C@H](CCSC)NC(=O)N1CCc2[nH]c[nH+]c2[C@@H]1c1ccc(F)c(F)c1F to have a higher LogP value.,COC(=O)[C@H](CCSC)NC(=O)N1CCc2[nH]c[nH+]c2[C@@H]1c1ccc(F)c(F)c1F,2.1978999999999997
146375,Optimize the molecule O=C(Cc1csc(NC(=O)c2ccccc2)n1)Nc1cccc(Cl)c1F to have a higher LogP value.,O=C(Cc1csc(NC(=O)c2ccccc2)n1)Nc1cccc(Cl)c1F,4.369100000000001
184299,Please modify the molecule O=C(CCCSc1ccc(F)cc1)Nc1nnc(-c2ccc3c(c2)OCCO3)o1 to decrease its LogP value.,O=C(CCCSc1ccc(F)cc1)Nc1nnc(-c2ccc3c(c2)OCCO3)o1,4.157900000000002
171645,Modify the molecule Cn1nc(C(=O)N2CCC[C@H](c3cccc(-c4cccc(Cl)c4)n3)C2)ccc1=O to have a higher LogP value.,Cn1nc(C(=O)N2CCC[C@H](c3cccc(-c4cccc(Cl)c4)n3)C2)ccc1=O,3.515500000000002
130161,Optimize the molecule CCCOc1ccc2cc(C(=O)Nc3ccccc3[N+](=O)[O-])c(=O)oc2c1 to have a lower LogP value.,CCCOc1ccc2cc(C(=O)Nc3ccccc3[N+](=O)[O-])c(=O)oc2c1,3.742300000000002
92531,Modify the molecule COC1(C[NH2+][C@@H](C)CC(=O)N(C)c2ccccc2)CCOCC1 to increase its LogP value.,COC1(C[NH2+][C@@H](C)CC(=O)N(C)c2ccccc2)CCOCC1,1.1870000000000005
213635,Please optimize the molecule CC[C@H]1NC(=O)C[C@H](C)N(Cc2cccc(C)n2)C1=O to have a lower LogP value.,CC[C@H]1NC(=O)C[C@H](C)N(Cc2cccc(C)n2)C1=O,1.4056199999999996
40912,Please modify the molecule CC[C@](C)(NC(=O)Nc1cc(CC(C)C)nn1C)c1nccs1 to decrease its LogP value.,CC[C@](C)(NC(=O)Nc1cc(CC(C)C)nn1C)c1nccs1,3.522000000000003
76159,Please optimize the molecule O=C(CNC(=O)c1ccc2c(c1)OCO2)NCC1(c2ccccc2)CCCC1 to have a lower LogP value.,O=C(CNC(=O)c1ccc2c(c1)OCO2)NCC1(c2ccccc2)CCCC1,2.7733000000000008
172480,Optimize the molecule Cc1ccc(NC(=O)c2cc3c(=O)c4ccccc4oc3o2)c(C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)c2cc3c(=O)c4ccccc4oc3o2)c(C)c1,4.408340000000003
60947,Modify the molecule Cc1nc(Cl)sc1C(=O)N1CCC(OCc2ccccc2F)CC1 to have a higher LogP value.,Cc1nc(Cl)sc1C(=O)N1CCC(OCc2ccccc2F)CC1,4.065420000000003
191024,Modify the molecule O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1 to have a higher LogP value.,O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1,2.2679
216405,Optimize the molecule Cc1cccc(OCc2nnc(SCCS(C)(=O)=O)o2)c1 to have a lower LogP value.,Cc1cccc(OCc2nnc(SCCS(C)(=O)=O)o2)c1,2.09372
138691,Optimize the molecule CCc1cc(=O)[nH]c(SCC(=O)Nc2cccc(Cl)c2)n1 to have a lower LogP value.,CCc1cc(=O)[nH]c(SCC(=O)Nc2cccc(Cl)c2)n1,2.716500000000001
171668,Please modify the molecule Cc1cc(C[NH2+]Cc2c(C)nc3sccn23)cc(C)c1F to increase its LogP value.,Cc1cc(C[NH2+]Cc2c(C)nc3sccn23)cc(C)c1F,2.7237600000000013
9938,Please optimize the molecule O=C(N[C@H](CC(=O)N1CCC[C@H]2CCCC[C@@H]21)c1ccccc1)c1ccccc1Cl to have a lower LogP value.,O=C(N[C@H](CC(=O)N1CCC[C@H]2CCCC[C@@H]21)c1ccccc1)c1ccccc1Cl,5.382400000000006
163135,Modify the molecule Cc1ccc2nc(COC(=O)c3ccccc3OCc3csc(C)n3)cc(=O)n2c1 to have a higher LogP value.,Cc1ccc2nc(COC(=O)c3ccccc3OCc3csc(C)n3)cc(=O)n2c1,3.7038400000000022
220555,Optimize the molecule CCOC(=O)c1cccc(N2CCCC[C@@H](SCC)C2)n1 to have a lower LogP value.,CCOC(=O)c1cccc(N2CCCC[C@@H](SCC)C2)n1,3.370300000000002
209361,Please optimize the molecule Nc1ccc(N2CCSC2=O)nc1 to have a lower LogP value.,Nc1ccc(N2CCSC2=O)nc1,1.337
105945,Optimize the molecule C[NH+]1CCN(C[C@@H]2CO2)CC1 to have a lower LogP value.,C[NH+]1CCN(C[C@@H]2CO2)CC1,-1.7844999999999973
43849,Modify the molecule C[NH+](C)C[C@@H]1C[C@H](C(C)(C)C)CCC1=O to have a lower LogP value.,C[NH+](C)C[C@@H]1C[C@H](C(C)(C)C)CCC1=O,1.1623999999999999
148772,Optimize the molecule Cn1ccc(C(=O)NCCc2ccc3c(c2)OCO3)cc1=O to have a lower LogP value.,Cn1ccc(C(=O)NCCc2ccc3c(c2)OCO3)cc1=O,1.0864999999999998
194647,Please modify the molecule CC(C)(C)c1cc(NC(=O)C(=O)N2CCCC2)no1 to increase its LogP value.,CC(C)(C)c1cc(NC(=O)C(=O)N2CCCC2)no1,1.533
66529,Modify the molecule COc1ccccc1/C=C/C(=O)NC(=S)NNC(=O)c1ccccc1Br to increase its LogP value.,COc1ccccc1/C=C/C(=O)NC(=S)NNC(=O)c1ccccc1Br,2.8066000000000004
116089,Modify the molecule CCOc1ccc(CC(=O)N[C@@H](CC)c2c(C)nn(C)c2C)cc1 to have a higher LogP value.,CCOc1ccc(CC(=O)N[C@@H](CC)c2c(C)nn(C)c2C)cc1,3.2456400000000016
40046,Modify the molecule O=C(CC[S@@](=O)c1ccc2c(c1)OCCO2)NCCC(F)(F)F to have a higher LogP value.,O=C(CC[S@@](=O)c1ccc2c(c1)OCCO2)NCCC(F)(F)F,2.0241
206348,Please optimize the molecule O=C(NCCC[NH2+]C1CCCCC1)Nc1cnn(-c2ccccc2F)c1 to have a lower LogP value.,O=C(NCCC[NH2+]C1CCCCC1)Nc1cnn(-c2ccccc2F)c1,2.4191000000000003
214341,Modify the molecule Cc1cc(C)c(C(=O)N(C)CC(C)(C)C)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(C(=O)N(C)CC(C)(C)C)c(C)c1,3.729960000000003
51668,Modify the molecule Cc1nc2ccc(NC(=O)N3CCC[C@@H](C)CC3)cc2o1 to decrease its LogP value.,Cc1nc2ccc(NC(=O)N3CCC[C@@H](C)CC3)cc2o1,3.7901200000000026
15225,Please modify the molecule CCN(CC(=O)N(C)C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1 to decrease its LogP value.,CCN(CC(=O)N(C)C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1,0.2077000000000021
144928,Optimize the molecule CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21 to have a higher LogP value.,CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21,3.0666900000000012
164006,Modify the molecule COC(=O)c1ccccc1OC(=O)c1ccsc1 to have a higher LogP value.,COC(=O)c1ccccc1OC(=O)c1ccsc1,2.7539000000000016
95432,Optimize the molecule CCOc1ccc(NC(=O)NCCCN2CCOCC2)cc1F to have a higher LogP value.,CCOc1ccc(NC(=O)NCCCN2CCOCC2)cc1F,2.0681999999999996
141385,Optimize the molecule Cc1ccc2cccc(NC(=O)[C@@H](C)SCc3nc4scc(-c5ccccc5)c4c(=O)[nH]3)c2n1 to have a higher LogP value.,Cc1ccc2cccc(NC(=O)[C@@H](C)SCc3nc4scc(-c5ccccc5)c4c(=O)[nH]3)c2n1,5.768620000000005
41774,Optimize the molecule CC(C)[C@]1(O)CN(S(=O)(=O)c2ccc3c(c2)CCC(=O)N3)C[C@H]1C to have a lower LogP value.,CC(C)[C@]1(O)CN(S(=O)(=O)c2ccc3c(c2)CCC(=O)N3)C[C@H]1C,1.5988000000000002
87612,Please modify the molecule C/C(=N\N[C@@H]1N=CN=N1)c1ccc(Cl)c(Cl)c1 to decrease its LogP value.,C/C(=N\N[C@@H]1N=CN=N1)c1ccc(Cl)c(Cl)c1,3.0847000000000016
24658,Modify the molecule COc1cc(NS(C)(=O)=O)c(OC)cc1Cl to increase its LogP value.,COc1cc(NS(C)(=O)=O)c(OC)cc1Cl,1.7287
195458,Modify the molecule CCNC(=O)N1CCN(Cc2csc(-c3ccc(Cl)cc3)n2)CC1 to have a higher LogP value.,CCNC(=O)N1CCN(Cc2csc(-c3ccc(Cl)cc3)n2)CC1,3.3106000000000018
196808,Optimize the molecule O=C([O-])c1ccccc1C(=O)N1CCS[C@H]1c1ccccc1 to have a lower LogP value.,O=C([O-])c1ccccc1C(=O)N1CCS[C@H]1c1ccccc1,1.9379
66708,Modify the molecule Cc1ccc(/C=C/C(=O)N2CCN(Cc3cccnc3)CC2)cc1Cl to have a higher LogP value.,Cc1ccc(/C=C/C(=O)N2CCN(Cc3cccnc3)CC2)cc1Cl,3.4010200000000026
213589,Optimize the molecule Cc1noc(C)c1S(=O)(=O)NNC(=O)CC12CC3CC(CC(C3)C1)C2 to have a lower LogP value.,Cc1noc(C)c1S(=O)(=O)NNC(=O)CC12CC3CC(CC(C3)C1)C2,2.207439999999999
49679,Modify the molecule COc1ccccc1[C@H](NC(=O)NCc1ccccn1)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@H](NC(=O)NCc1ccccn1)c1ccccn1,3.0740000000000016
9655,Please modify the molecule CC[C@H]([NH2+][C@@H]1CCCC1(C)C)c1ccc(C)cc1 to increase its LogP value.,CC[C@H]([NH2+][C@@H]1CCCC1(C)C)c1ccc(C)cc1,3.5882200000000024
123027,Modify the molecule CC(C)CCO[C@@H]1CCCC[C@@H]1NC(=O)c1nccn2ccnc12 to have a lower LogP value.,CC(C)CCO[C@@H]1CCCC[C@@H]1NC(=O)c1nccn2ccnc12,2.833000000000001
122084,Optimize the molecule Cc1cccc(OCCNC(=O)COc2ccc3c(C)cc(=O)oc3c2)c1 to have a lower LogP value.,Cc1cccc(OCCNC(=O)COc2ccc3c(C)cc(=O)oc3c2)c1,2.9838400000000007
242460,Please optimize the molecule CS(=O)(=O)c1ccc(SCCCCS)cc1 to have a higher LogP value.,CS(=O)(=O)c1ccc(SCCCCS)cc1,2.8922000000000017
53602,Optimize the molecule CCCCN1C(=O)c2ccc(C(=O)Nc3ccc(-n4cnnn4)cc3)cc2C1=O to have a higher LogP value.,CCCCN1C(=O)c2ccc(C(=O)Nc3ccc(-n4cnnn4)cc3)cc2C1=O,2.3106999999999998
21276,Modify the molecule Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1 to have a higher LogP value.,Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1,-1.1782599999999943
61340,Modify the molecule COCc1cccc(C(=O)Nc2cc(C)nn2-c2ccc(C)nn2)c1 to have a higher LogP value.,COCc1cccc(C(=O)Nc2cc(C)nn2-c2ccc(C)nn2)c1,2.6778400000000007
90190,Modify the molecule Cc1[nH]n(-c2nc(-c3ccccc3)cs2)c(=O)c1[C@@H](c1ccccc1)[C@@H](C#N)C(N)=O to decrease its LogP value.,Cc1[nH]n(-c2nc(-c3ccccc3)cs2)c(=O)c1[C@@H](c1ccccc1)[C@@H](C#N)C(N)=O,3.3545000000000016
166520,Please modify the molecule NC(=S)c1[nH+]ccn1CC(=O)Nc1ccc(Br)cc1 to decrease its LogP value.,NC(=S)c1[nH+]ccn1CC(=O)Nc1ccc(Br)cc1,1.3375999999999997
118480,Modify the molecule O=C([C@H]1CC(=O)N(c2cccc(F)c2)C1)N1CCCCC1 to increase its LogP value.,O=C([C@H]1CC(=O)N(c2cccc(F)c2)C1)N1CCCCC1,2.1911000000000005
174379,Modify the molecule O=C(COc1ccccc1)Nc1nc(-c2ccc(Br)cc2)ns1 to increase its LogP value.,O=C(COc1ccccc1)Nc1nc(-c2ccc(Br)cc2)ns1,3.985100000000002
52819,Optimize the molecule N#Cc1ccc(Cl)c(NC(=O)NCCCCn2ccccc2=O)c1 to have a lower LogP value.,N#Cc1ccc(Cl)c(NC(=O)NCCCCn2ccccc2=O)c1,2.9752800000000015
179095,Modify the molecule COc1cccc([C@H]2NC(=O)NC(C)=C2C(=O)OCCC#N)c1 to decrease its LogP value.,COc1cccc([C@H]2NC(=O)NC(C)=C2C(=O)OCCC#N)c1,1.77998
133740,Please optimize the molecule Cc1nc2ccccc2c(=O)n1N[C@@H](O)C(Cl)(Cl)Cl to have a lower LogP value.,Cc1nc2ccccc2c(=O)n1N[C@@H](O)C(Cl)(Cl)Cl,1.93702
149637,Please modify the molecule COc1ccc(NC(=O)COc2ccc(C)cc2-n2cnnc2)cc1OC to decrease its LogP value.,COc1ccc(NC(=O)COc2ccc(C)cc2-n2cnnc2)cc1OC,2.6104200000000004
213870,Please modify the molecule O=C1CC[C@H](COC(=O)c2cccc(Br)c2)N1 to increase its LogP value.,O=C1CC[C@H](COC(=O)c2cccc(Br)c2)N1,1.8844999999999998
9689,Please modify the molecule CC(=O)c1cc(F)c(C)cc1N1CCO[C@H](C)C1 to increase its LogP value.,CC(=O)c1cc(F)c(C)cc1N1CCO[C@H](C)C1,2.561820000000001
215148,Modify the molecule COCCn1nc(C)c(CNC(=O)N[C@@H]2CCC[C@H]2C(N)=O)c1C to increase its LogP value.,COCCn1nc(C)c(CNC(=O)N[C@@H]2CCC[C@H]2C(N)=O)c1C,0.5995400000000014
56806,Optimize the molecule C[C@H]1Cc2ccc(CNC(=O)CSCc3ccc(F)cc3)cc2N1C(=O)c1ccccc1 to have a lower LogP value.,C[C@H]1Cc2ccc(CNC(=O)CSCc3ccc(F)cc3)cc2N1C(=O)c1ccccc1,4.966700000000005
31911,Modify the molecule Cc1cc(C)c2oc(=O)n(C3CCN(C(=O)c4ccc(C#N)cc4)CC3)c2c1 to have a higher LogP value.,Cc1cc(C)c2oc(=O)n(C3CCN(C(=O)c4ccc(C#N)cc4)CC3)c2c1,3.5603200000000026
22748,Modify the molecule Cc1cccc(-c2nnc([S-])n2CC(=O)NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1 to decrease its LogP value.,Cc1cccc(-c2nnc([S-])n2CC(=O)NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1,3.084920000000001
7891,Optimize the molecule O=C(Nc1ccccc1C(=O)NCc1ccco1)C1=CCCCO1 to have a lower LogP value.,O=C(Nc1ccccc1C(=O)NCc1ccco1)C1=CCCCO1,2.8424000000000014
207235,Optimize the molecule CC[C@H](NC(=O)NCc1ccc(C)cc1OC(C)(C)C)c1nccs1 to have a higher LogP value.,CC[C@H](NC(=O)NCc1ccc(C)cc1OC(C)(C)C)c1nccs1,4.579320000000004
134022,Modify the molecule Cc1nn(CN2CCO[C@@H](C(N)=O)C2)c(C)c1Br to have a higher LogP value.,Cc1nn(CN2CCO[C@@H](C(N)=O)C2)c(C)c1Br,0.40603999999999985
97354,Modify the molecule N#Cc1cccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2F)c1 to have a higher LogP value.,N#Cc1cccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2F)c1,2.3732800000000003
179382,Please optimize the molecule COCc1cc(NC(=O)C(=O)NCCc2ccc(Cl)cc2)ncn1 to have a lower LogP value.,COCc1cc(NC(=O)C(=O)NCCc2ccc(Cl)cc2)ncn1,1.5737999999999999
196992,Please modify the molecule CC[NH2+][C@H](C)[C@H]1CCC[NH+](C(CC)CC)C1 to increase its LogP value.,CC[NH2+][C@H](C)[C@H]1CCC[NH+](C(CC)CC)C1,0.441700000000002
217225,Please modify the molecule Cn1ccc(C(=O)N[C@@H]2CCCN(Cc3ccccc3)C2=O)c1 to increase its LogP value.,Cn1ccc(C(=O)N[C@@H]2CCCN(Cc3ccccc3)C2=O)c1,1.9461
3565,Modify the molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 to decrease its LogP value.,[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1,-1.7804999999999995
156539,Modify the molecule COc1ccc(CN2C[C@H](C)OCC2(C)C)cc1 to decrease its LogP value.,COc1ccc(CN2C[C@H](C)OCC2(C)C)cc1,2.6945000000000006
177417,Optimize the molecule O=C(Cc1noc(-c2csc([N+](=O)[O-])c2)n1)NCc1ccccc1 to have a higher LogP value.,O=C(Cc1noc(-c2csc([N+](=O)[O-])c2)n1)NCc1ccccc1,2.565200000000001
172617,Optimize the molecule O=C(NCCCOc1cccc2cccnc12)c1cc2ccccc2oc1=O to have a lower LogP value.,O=C(NCCCOc1cccc2cccnc12)c1cc2ccccc2oc1=O,3.5401000000000025
248384,Modify the molecule CC(=O)c1ccc(NC(=O)N[C@H]2[C@@H]3CCO[C@@H]3C23CCC3)cc1C to have a higher LogP value.,CC(=O)c1ccc(NC(=O)N[C@H]2[C@@H]3CCO[C@@H]3C23CCC3)cc1C,3.276720000000002
138763,Please modify the molecule CCc1ccc2c(c1)C(c1cccs1)=NNC(c1cccnc1)=N2 to increase its LogP value.,CCc1ccc2c(c1)C(c1cccs1)=NNC(c1cccnc1)=N2,4.139400000000003
10063,Please optimize the molecule CCC[C@@H]1CN(Cc2cc(Cl)ccc2[N+](=O)[O-])CC[NH2+]1 to have a lower LogP value.,CCC[C@@H]1CN(Cc2cc(Cl)ccc2[N+](=O)[O-])CC[NH2+]1,1.7959
241619,Modify the molecule C[C@H](CNC(=O)Cn1cnc2ccc(F)cc2c1=O)Cn1cccn1 to increase its LogP value.,C[C@H](CNC(=O)Cn1cnc2ccc(F)cc2c1=O)Cn1cccn1,1.1845999999999992
176807,Please modify the molecule CNC(=O)c1ccc(/C=C/C(=O)NC[C@@H](OC)c2ccccc2)cc1 to increase its LogP value.,CNC(=O)c1ccc(/C=C/C(=O)NC[C@@H](OC)c2ccccc2)cc1,2.563300000000001
219650,Modify the molecule COc1cccc(OC)c1C(=O)NCC[NH+]1CCN(c2ccc(F)cc2)CC1 to increase its LogP value.,COc1cccc(OC)c1C(=O)NCC[NH+]1CCN(c2ccc(F)cc2)CC1,0.9778000000000009
94616,Please optimize the molecule CN1C(=O)C[C@H](NC(=O)C2([NH+](C)C)CCC2)[C@@H]1c1ccc(Cl)cc1 to have a higher LogP value.,CN1C(=O)C[C@H](NC(=O)C2([NH+](C)C)CCC2)[C@@H]1c1ccc(Cl)cc1,0.7952000000000012
17046,Please optimize the molecule N#CCCCC(=O)c1ccccc1I to have a lower LogP value.,N#CCCCC(=O)c1ccccc1I,3.1677800000000023
49317,Please modify the molecule CC[NH+](Cc1cc(Br)ccc1O)[C@H](C)c1nnc(C)o1 to increase its LogP value.,CC[NH+](Cc1cc(Br)ccc1O)[C@H](C)c1nnc(C)o1,2.01212
31212,Modify the molecule COc1cc2c(c(OC)c1OC)[C@@H](c1ccc(Br)cc1)CC(=O)N2 to increase its LogP value.,COc1cc2c(c(OC)c1OC)[C@@H](c1ccc(Br)cc1)CC(=O)N2,3.9490000000000025
125734,Please modify the molecule CC(C)/C(=C\C1CCCC1)CBr to decrease its LogP value.,CC(C)/C(=C\C1CCCC1)CBr,4.153900000000004
193899,Optimize the molecule CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1 to have a higher LogP value.,CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1,3.7447000000000026
229186,Modify the molecule CC(=O)N1CCCc2cc(S(=O)(=O)NCc3ccc(OC(C)C)cc3)ccc21 to increase its LogP value.,CC(=O)N1CCCc2cc(S(=O)(=O)NCc3ccc(OC(C)C)cc3)ccc21,3.251400000000002
51582,Please optimize the molecule CC[NH+](CC)CCNc1cc(OC)cc2nccnc12 to have a higher LogP value.,CC[NH+](CC)CCNc1cc(OC)cc2nccnc12,0.9750000000000003
16742,Modify the molecule CCOc1ccc(NC(=O)CN(c2cccc(F)c2)S(C)(=O)=O)cc1 to have a higher LogP value.,CCOc1ccc(NC(=O)CN(c2cccc(F)c2)S(C)(=O)=O)cc1,2.629100000000001
213955,Modify the molecule [NH3+]C1CCC(OC(=O)Nc2ccc(F)cc2)CC1 to have a higher LogP value.,[NH3+]C1CCC(OC(=O)Nc2ccc(F)cc2)CC1,1.9272999999999993
171503,Modify the molecule CON(C)C(=O)CN(C)[C@H]1CCCN(c2ccccc2)C1 to decrease its LogP value.,CON(C)C(=O)CN(C)[C@H]1CCCN(c2ccccc2)C1,1.6069999999999989
224715,Modify the molecule CCOc1ccc(N(C)S(=O)(=O)Cc2cccc(C#N)c2)cc1 to increase its LogP value.,CCOc1ccc(N(C)S(=O)(=O)Cc2cccc(C#N)c2)cc1,2.923180000000001
186638,Optimize the molecule O=C(NCc1cccc2cccnc12)c1csc(-c2ccco2)n1 to have a lower LogP value.,O=C(NCc1cccc2cccnc12)c1csc(-c2ccco2)n1,3.881300000000003
214780,Modify the molecule CCn1cc(C[NH2+]Cc2ccc(OC)cc2OC)cn1 to have a lower LogP value.,CCn1cc(C[NH2+]Cc2ccc(OC)cc2OC)cn1,1.183799999999999
168131,Optimize the molecule Cc1csc(NC(=O)c2sc(-c3ccccc3F)nc2C)n1 to have a higher LogP value.,Cc1csc(NC(=O)c2sc(-c3ccccc3F)nc2C)n1,4.274840000000003
31676,Please modify the molecule CC(C)Cn1ccnc(Oc2ccc(OCC(N)=O)cc2)c1=O to decrease its LogP value.,CC(C)Cn1ccnc(Oc2ccc(OCC(N)=O)cc2)c1=O,1.5556999999999999
91319,Modify the molecule CC(C)(C)C[NH+](CCC#N)Cc1nc(-c2cccc(Br)c2)no1 to decrease its LogP value.,CC(C)(C)C[NH+](CCC#N)Cc1nc(-c2cccc(Br)c2)no1,2.8437800000000015
148032,Modify the molecule CN(C)c1ccc(/C=C(/C#N)C(N)=O)cc1 to have a lower LogP value.,CN(C)c1ccc(/C=C(/C#N)C(N)=O)cc1,1.14488
138843,Modify the molecule Cc1ccn2nc(N[C@@H](C)c3cccs3)nc2c1 to have a higher LogP value.,Cc1ccn2nc(N[C@@H](C)c3cccs3)nc2c1,3.2723200000000014
89029,Please modify the molecule COc1ccc(-n2nc(C(=O)Oc3c(F)cccc3OC)cc2C)cc1 to increase its LogP value.,COc1ccc(-n2nc(C(=O)Oc3c(F)cccc3OC)cc2C)cc1,3.5562200000000024
132729,Modify the molecule COc1ccc2cccc(CC(=O)N[C@@H]3CCCc4cn[nH]c43)c2c1 to increase its LogP value.,COc1ccc2cccc(CC(=O)N[C@@H]3CCCc4cn[nH]c43)c2c1,3.307800000000001
226936,Modify the molecule CCc1nnc(SCCC(=O)Nc2ccc(C)cc2)n1-c1ccccc1 to have a lower LogP value.,CCc1nnc(SCCC(=O)Nc2ccc(C)cc2)n1-c1ccccc1,4.259020000000003
32370,Please modify the molecule COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12 to decrease its LogP value.,COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12,2.5989000000000004
56914,Please optimize the molecule C[S@](=O)CCNC(=O)Nc1cc(-c2ccccc2)on1 to have a lower LogP value.,C[S@](=O)CCNC(=O)Nc1cc(-c2ccccc2)on1,1.8415999999999995
59612,Please optimize the molecule C[C@@H]1CN(Cc2ccccc2CNC(=O)c2cccc3cn[nH]c23)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CN(Cc2ccccc2CNC(=O)c2cccc3cn[nH]c23)C[C@@H](C)O1,3.102100000000001
97640,Modify the molecule CCC(=O)N1CCN(c2cc(C)cc(C)c2)C(=O)[C@@H]1C to have a higher LogP value.,CCC(=O)N1CCN(c2cc(C)cc(C)c2)C(=O)[C@@H]1C,2.27714
202381,Please modify the molecule COCc1ccccc1C(=O)N1CCC[C@@H](c2nc(C)cs2)C1 to increase its LogP value.,COCc1ccccc1C(=O)N1CCC[C@@H](c2nc(C)cs2)C1,3.617720000000003
74820,Modify the molecule CC[C@H](C)NS(=O)(=O)c1ccc(NC=C2C(=O)CC(C)(C)CC2=O)cc1 to decrease its LogP value.,CC[C@H](C)NS(=O)(=O)c1ccc(NC=C2C(=O)CC(C)(C)CC2=O)cc1,3.017400000000001
189845,Please modify the molecule CC(C)OC(=O)C1=C(N)Oc2c(c(=O)sc3ccccc23)[C@H]1c1cccnc1 to increase its LogP value.,CC(C)OC(=O)C1=C(N)Oc2c(c(=O)sc3ccccc23)[C@H]1c1cccnc1,3.3027000000000015
242747,Please optimize the molecule C[C@H]1CCC[C@@H]([NH+]2CCN(C(=O)c3cccc(Cl)c3)CC2)C1 to have a lower LogP value.,C[C@H]1CCC[C@@H]([NH+]2CCN(C(=O)c3cccc(Cl)c3)CC2)C1,2.2594000000000003
196372,Modify the molecule C[C@H](Sc1nnc(C2CC2)n1C)C(=O)Nc1c(F)cccc1F to increase its LogP value.,C[C@H](Sc1nnc(C2CC2)n1C)C(=O)Nc1c(F)cccc1F,3.0900000000000016
5953,Please modify the molecule O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccccc2)CC1 to decrease its LogP value.,O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccccc2)CC1,2.700500000000001
244602,Please optimize the molecule COc1ccc(Br)cc1[C@@H]1CC(=O)N2CN(c3ccc(Cl)cc3)CSC2=C1C#N to have a higher LogP value.,COc1ccc(Br)cc1[C@@H]1CC(=O)N2CN(c3ccc(Cl)cc3)CSC2=C1C#N,5.330580000000003
82239,Modify the molecule CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(C(C)C)c1 to increase its LogP value.,CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(C(C)C)c1,2.9445000000000006
48077,Please optimize the molecule CCC[C@H](C)NC(=O)[C@H](C)N1CCN(C(=O)c2ccco2)CC1 to have a higher LogP value.,CCC[C@H](C)NC(=O)[C@H](C)N1CCN(C(=O)c2ccco2)CC1,1.7306999999999997