episode_id large_string | target_gene large_string | target_cell large_string | target_cell_id large_string | target_direction large_string | label int64 | negative_type large_string | sufficiency_tier large_string | lineage large_string | ood_group large_string | ground_truth dict | target_gene_meta dict | target_cell_meta dict | context_pool list |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
c21e8a79-b14 | PDHB | NCIH1573 | ACH-000916 | essential | 0 | refuted | poor | Lung | iid | {
"chronos": 0.357,
"p_dependency": 0.003
} | {
"symbol": "PDHB",
"name": "pyruvate dehydrogenase E1 subunit beta",
"family": "Pyruvate dehydrogenase complex",
"ensembl_id": null
} | {
"cell_name": "NCIH1573",
"model_id": "ACH-000916",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"KRAS",
"ERBB3",
"STK11"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "GHSR",
"gene_metadata": {
"symbol": "GHSR",
"name": "growth hormone secretagogue receptor",
"family": "Peptide receptors",
"ensembl_id": null
},
"cell": "NCIH1573",
"cell_metadata": ... |
46f72eac-78e | VPS33A | NCIH157DM | ACH-000921 | essential | 1 | null | rich | Lung | iid | {
"chronos": -0.633,
"p_dependency": 0.862
} | {
"symbol": "VPS33A",
"name": "VPS33A core subunit of CORVET and HOPS complexes",
"family": "HOPS complex|CORVET complex",
"ensembl_id": null
} | {
"cell_name": "NCIH157DM",
"model_id": "ACH-000921",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"KRAS",
"TP53"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "IL31",
"gene_metadata": {
"symbol": "IL31",
"name": "interleukin 31",
"family": "Interleukins",
"ensembl_id": null
},
"cell": "NCIH157DM",
"cell_metadata": {
"cell_name": "NCIH... |
28137875-482 | CAP1 | LN340 | ACH-000634 | essential | 1 | null | rich | CNS/Brain | iid | {
"chronos": -0.787,
"p_dependency": 0.919
} | {
"symbol": "CAP1",
"name": "cyclase associated actin cytoskeleton regulatory protein 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "LN340",
"model_id": "ACH-000634",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Glioblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "CAP1",
"gene_metadata": {
"symbol": "CAP1",
"name": "cyclase associated actin cytoskeleton regulatory protein 1",
"family": null,
"ensembl_id": null
},
"cell": "LN340",
... |
de6ffdb5-fca | FAAP20 | COV362 | ACH-000278 | essential | 1 | null | moderate | Ovary/Fallopian Tube | iid | {
"chronos": -0.906,
"p_dependency": 0.892
} | {
"symbol": "FAAP20",
"name": "FA core complex associated protein 20",
"family": null,
"ensembl_id": null
} | {
"cell_name": "COV362",
"model_id": "ACH-000278",
"lineage": "Ovary/Fallopian Tube",
"disease": "Ovarian Epithelial Tumor",
"subtype": "High-Grade Serous Ovarian Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "FAAP20",
"gene_metadata": {
"symbol": "FAAP20",
"name": "FA core complex associated protein 20",
"family": null,
"ensembl_id": null
},
"cell": "COV362",
"cell_metadat... |
7e21f3e1-8ec | RBM34 | NCIH1568 | ACH-000869 | essential | 0 | inconclusive | moderate | Lung | iid | {
"chronos": -0.084,
"p_dependency": 0.059
} | {
"symbol": "RBM34",
"name": "RNA binding motif protein 34",
"family": "RNA binding motif containing",
"ensembl_id": null
} | {
"cell_name": "NCIH1568",
"model_id": "ACH-000869",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "OC90",
"gene_metadata": {
"symbol": "OC90",
"name": "otoconin 90",
"family": null,
"ensembl_id": null
},
"cell": "NCIH1568",
"cell_metadata": {
"cell_name": "NCIH1568",
"... |
3b395923-c7b | PRRC2C | HEC251 | ACH-000996 | essential | 0 | inconclusive | moderate | Uterus | iid | {
"chronos": -0.329,
"p_dependency": 0.245
} | {
"symbol": "PRRC2C",
"name": "proline rich coiled-coil 2C",
"family": null,
"ensembl_id": null
} | {
"cell_name": "HEC251",
"model_id": "ACH-000996",
"lineage": "Uterus",
"disease": "Endometrial Carcinoma",
"subtype": "Endometrial Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"HFM1",
"PTEN",
"COL17A1"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "PRRC2C",
"gene_metadata": {
"symbol": "PRRC2C",
"name": "proline rich coiled-coil 2C",
"family": null,
"ensembl_id": null
},
"cell": "ESS1",
"cell_metadata": {
"c... |
a3d9cc97-cf8 | SLC35B2 | VMCUB1 | ACH-000545 | essential | 1 | null | rich | Bladder/Urinary Tract | iid | {
"chronos": -0.55,
"p_dependency": 0.742
} | {
"symbol": "SLC35B2",
"name": "solute carrier family 35 member B2",
"family": "MicroRNA protein coding host genes|Solute carrier family 35",
"ensembl_id": null
} | {
"cell_name": "VMCUB1",
"model_id": "ACH-000545",
"lineage": "Bladder/Urinary Tract",
"disease": "Bladder Urothelial Carcinoma",
"subtype": "Bladder Urothelial Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CA",
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "CER1",
"gene_metadata": {
"symbol": "CER1",
"name": "cerberus 1, DAN family BMP antagonist",
"family": "DAN family",
"ensembl_id": null
},
"cell": "VMCUB1",
"cell_metadata": {
... |
b302b069-559 | CYP27B1 | HEL9217 | ACH-000005 | essential | 1 | null | moderate | Myeloid | iid | {
"chronos": -0.704,
"p_dependency": 0.798
} | {
"symbol": "CYP27B1",
"name": "cytochrome P450 family 27 subfamily B member 1",
"family": "Cytochrome P450 family 27",
"ensembl_id": null
} | {
"cell_name": "HEL9217",
"model_id": "ACH-000005",
"lineage": "Myeloid",
"disease": "Acute Myeloid Leukemia",
"subtype": "Acute Myeloid Leukemia",
"sex": "Male",
"primary_metastasis": null,
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "SLC22A8",
"gene_metadata": {
"symbol": "SLC22A8",
"name": "solute carrier family 22 member 8",
"family": "Solute carrier family 22",
"ensembl_id": null
},
"cell": "HEL9217",
"cell_me... |
b61ffd34-358 | LMO2 | EOL1 | ACH-000198 | essential | 1 | null | poor | Myeloid | iid | {
"chronos": -0.724,
"p_dependency": 0.951
} | {
"symbol": "LMO2",
"name": "LIM domain only 2",
"family": "LIM domain containing",
"ensembl_id": null
} | {
"cell_name": "EOL1",
"model_id": "ACH-000198",
"lineage": "Myeloid",
"disease": "Myeloproliferative Neoplasms",
"subtype": "Chronic Eosinophilic Leukemia, NOS",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CB"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "LMO2",
"gene_metadata": {
"symbol": "LMO2",
"name": "LIM domain only 2",
"family": "LIM domain containing",
"ensembl_id": null
},
"cell": "EOL1",
"cell_metadata": {
"c... |
47fdeac9-899 | CCNF | DOTC24510 | ACH-001341 | essential | 0 | refuted | poor | Cervix | lineage | {
"chronos": 0.255,
"p_dependency": 0.006
} | {
"symbol": "CCNF",
"name": "cyclin F",
"family": "Cyclins|F-boxes other|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "DOTC24510",
"model_id": "ACH-001341",
"lineage": "Cervix",
"disease": "Mixed Cervical Carcinoma",
"subtype": "Mixed Cervical Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "mutation",
"context_type": "molecular_mutation",
"related": true,
"gene": "CCNF",
"gene_metadata": {
"symbol": "CCNF",
"name": "cyclin F",
"family": "Cyclins|F-boxes other|MicroRNA protein coding host genes",
"ensembl_id": null
},
"cell": "DOTC24510... |
0b9c4b48-a26 | KRTAP10-9 | NCIH358 | ACH-000860 | essential | 1 | null | rich | Lung | gene | {
"chronos": -0.518,
"p_dependency": 0.622
} | {
"symbol": "KRTAP10-9",
"name": "keratin associated protein 10-9",
"family": "Keratin associated proteins",
"ensembl_id": null
} | {
"cell_name": "NCIH358",
"model_id": "ACH-000860",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "OR2T4",
"gene_metadata": {
"symbol": "OR2T4",
"name": "olfactory receptor family 2 subfamily T member 4",
"family": "Olfactory receptors, family 2",
"ensembl_id": null
},
"cell": "NCIH35... |
8aa3bf93-5eb | CEND1 | MCC13 | ACH-001550 | essential | 0 | inconclusive | moderate | Skin | iid | {
"chronos": -0.198,
"p_dependency": 0.082
} | {
"symbol": "CEND1",
"name": "cell cycle exit and neuronal differentiation 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "MCC13",
"model_id": "ACH-001550",
"lineage": "Skin",
"disease": "Merkel Cell Carcinoma",
"subtype": "Merkel Cell Carcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"HRAS",
"NPAP1",
"KNSTRN"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "CEND1",
"gene_metadata": {
"symbol": "CEND1",
"name": "cell cycle exit and neuronal differentiation 1",
"family": null,
"ensembl_id": null
},
"cell": "MM485",
"cell_met... |
7f0f8f04-91a | RAB14 | MV411 | ACH-000045 | essential | 0 | inconclusive | poor | Myeloid | iid | {
"chronos": -0.148,
"p_dependency": 0.075
} | {
"symbol": "RAB14",
"name": "RAB14, member RAS oncogene family",
"family": "RAB, member RAS oncogene GTPases",
"ensembl_id": null
} | {
"cell_name": "MV411",
"model_id": "ACH-000045",
"lineage": "Myeloid",
"disease": "Acute Myeloid Leukemia",
"subtype": "Acute Myeloid Leukemia",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "IFNA2",
"gene_metadata": {
"symbol": "IFNA2",
"name": "interferon alpha 2",
"family": "Interferons",
"ensembl_id": null
},
"cell": "MV411",
"cell_metadata": {
"cell_name": "MV4... |
d4585e2f-16a | COQ7 | MELHO | ACH-000450 | essential | 1 | null | moderate | Skin | iid | {
"chronos": -0.515,
"p_dependency": 0.536
} | {
"symbol": "COQ7",
"name": "coenzyme Q7, hydroxylase",
"family": null,
"ensembl_id": null
} | {
"cell_name": "MELHO",
"model_id": "ACH-000450",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT",
"BRAF"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "COQ7",
"gene_metadata": {
"symbol": "COQ7",
"name": "coenzyme Q7, hydroxylase",
"family": null,
"ensembl_id": null
},
"cell": "A375SKINCJ1",
"cell_metadata": {
"c... |
70942575-991 | EXTL2 | NCIH661 | ACH-000853 | essential | 1 | null | poor | Lung | gene | {
"chronos": -0.57,
"p_dependency": 0.765
} | {
"symbol": "EXTL2",
"name": "exostosin like glycosyltransferase 2",
"family": "Exostosin glycosyltransferase family",
"ensembl_id": null
} | {
"cell_name": "NCIH661",
"model_id": "ACH-000853",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Large Cell Lung Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "EXTL2",
"gene_metadata": {
"symbol": "EXTL2",
"name": "exostosin like glycosyltransferase 2",
"family": "Exostosin glycosyltransferase family",
"ensembl_id": null
},
"cel... |
479618a1-b0b | BSG | MM473 | ACH-001972 | essential | 0 | inconclusive | poor | Skin | iid | {
"chronos": -0.037,
"p_dependency": 0.025
} | {
"symbol": "BSG",
"name": "basigin (Ok blood group)",
"family": "Blood group antigens|CD molecules|I-set domain containing|Basigin family ",
"ensembl_id": null
} | {
"cell_name": "MM473",
"model_id": "ACH-001972",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TERT",
"BRAF"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "TRHR",
"gene_metadata": {
"symbol": "TRHR",
"name": "thyrotropin releasing hormone receptor",
"family": "Peptide receptors",
"ensembl_id": null
},
"cell": "MM473",
"cell_metadata": {... |
de130c37-391 | DVL1 | NRHUPS1 | ACH-003177 | essential | 0 | inconclusive | poor | Soft Tissue | iid | {
"chronos": -0.136,
"p_dependency": 0.077
} | {
"symbol": "DVL1",
"name": "dishevelled segment polarity protein 1",
"family": "Dishevelled segment polarity proteins|PDZ domain containing|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "NRHUPS1",
"model_id": "ACH-003177",
"lineage": "Soft Tissue",
"disease": "Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma",
"subtype": "Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma",
"s... | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "SEPTIN14",
"gene_metadata": {
"symbol": "SEPTIN14",
"name": "septin 14",
"family": "Septins",
"ensembl_id": null
},
"cell": "NRHUPS1",
"cell_metadata": {
"cell_name": "NRHUPS1"... |
ea4267f0-7a0 | STEAP3 | 95T1000 | ACH-001796 | essential | 0 | inconclusive | poor | Soft Tissue | iid | {
"chronos": -0.092,
"p_dependency": 0.059
} | {
"symbol": "STEAP3",
"name": "STEAP3 metalloreductase",
"family": "STEAP family|Flavoproteins",
"ensembl_id": null
} | {
"cell_name": "95T1000",
"model_id": "ACH-001796",
"lineage": "Soft Tissue",
"disease": "Liposarcoma",
"subtype": "Well-Differentiated Liposarcoma",
"sex": "Male",
"primary_metastasis": null,
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "IL36B",
"gene_metadata": {
"symbol": "IL36B",
"name": "interleukin 36 beta",
"family": "Interleukins",
"ensembl_id": null
},
"cell": "95T1000",
"cell_metadata": {
"cell_name": ... |
c11b1ba1-01c | VCPIP1 | NCIH2009 | ACH-000886 | essential | 1 | null | moderate | Lung | gene | {
"chronos": -0.567,
"p_dependency": 0.769
} | {
"symbol": "VCPIP1",
"name": "valosin containing protein interacting protein 1",
"family": "OTU domain containing",
"ensembl_id": null
} | {
"cell_name": "NCIH2009",
"model_id": "ACH-000886",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"CARNS1",
"KRAS",
"B2M"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "VCPIP1",
"gene_metadata": {
"symbol": "VCPIP1",
"name": "valosin containing protein interacting protein 1",
"family": "OTU domain containing",
"ensembl_id": null
},
"cell": "NCI... |
f0a10421-a4c | KCNK7 | OSC19 | ACH-001625 | essential | 0 | inconclusive | poor | Head and Neck | iid | {
"chronos": -0.21,
"p_dependency": 0.095
} | {
"symbol": "KCNK7",
"name": "potassium two pore domain channel subfamily K member 7",
"family": "Potassium two pore domain channel subfamily K ",
"ensembl_id": null
} | {
"cell_name": "OSC19",
"model_id": "ACH-001625",
"lineage": "Head and Neck",
"disease": "Head and Neck Squamous Cell Carcinoma",
"subtype": "Oral Cavity Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "KCNK7",
"gene_metadata": {
"symbol": "KCNK7",
"name": "potassium two pore domain channel subfamily K member 7",
"family": "Potassium two pore domain channel subfamily K ",
"ensembl... |
19246293-bab | EHBP1L1 | PEO4 | ACH-001632 | essential | 0 | inconclusive | poor | Ovary/Fallopian Tube | iid | {
"chronos": -0.23,
"p_dependency": 0.232
} | {
"symbol": "EHBP1L1",
"name": "EH domain binding protein 1 like 1",
"family": "NT-C2 domain containing",
"ensembl_id": null
} | {
"cell_name": "PEO4",
"model_id": "ACH-001632",
"lineage": "Ovary/Fallopian Tube",
"disease": "Ovarian Epithelial Tumor",
"subtype": "Serous Ovarian Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "EHBP1L1",
"gene_metadata": {
"symbol": "EHBP1L1",
"name": "EH domain binding protein 1 like 1",
"family": "NT-C2 domain containing",
"ensembl_id": null
},
"cell": "OVCAR8",... |
e91e5423-6bd | RILP | LN340 | ACH-000634 | essential | 1 | null | moderate | CNS/Brain | iid | {
"chronos": -0.589,
"p_dependency": 0.699
} | {
"symbol": "RILP",
"name": "Rab interacting lysosomal protein",
"family": null,
"ensembl_id": null
} | {
"cell_name": "LN340",
"model_id": "ACH-000634",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Glioblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "RILP",
"gene_metadata": {
"symbol": "RILP",
"name": "Rab interacting lysosomal protein",
"family": null,
"ensembl_id": null
},
"cell": "D283MED",
"cell_metadata": {
... |
d31b17bc-0ec | UBB | EBC1 | ACH-000563 | essential | 0 | inconclusive | moderate | Lung | gene | {
"chronos": -0.402,
"p_dependency": 0.323
} | {
"symbol": "UBB",
"name": "ubiquitin B",
"family": null,
"ensembl_id": null
} | {
"cell_name": "EBC1",
"model_id": "ACH-000563",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"CCND1",
"NFE2L2"
]
} | [
{
"modality": "crispr",
"context_type": "coessential_pathway",
"related": true,
"gene": "H4C9",
"gene_metadata": {
"symbol": "H4C9",
"name": "H4 clustered histone 9",
"family": "H4 histones|Proteins encoded by multiple genes",
"ensembl_id": null
},
"cell": "EBC1",... |
3f6583cc-91d | CYB5R4 | PANC0504 | ACH-000093 | essential | 1 | null | rich | Pancreas | iid | {
"chronos": -0.669,
"p_dependency": 0.599
} | {
"symbol": "CYB5R4",
"name": "cytochrome b5 reductase 4",
"family": "Flavoproteins",
"ensembl_id": null
} | {
"cell_name": "PANC0504",
"model_id": "ACH-000093",
"lineage": "Pancreas",
"disease": "Pancreatic Adenocarcinoma",
"subtype": "Pancreatic Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "KRTAP10-5",
"gene_metadata": {
"symbol": "KRTAP10-5",
"name": "keratin associated protein 10-5",
"family": "Keratin associated proteins",
"ensembl_id": null
},
"cell": "PANC0504",
"c... |
3e27063c-17c | UBAP2L | DMS273 | ACH-000749 | essential | 1 | null | rich | Lung | gene | {
"chronos": -0.587,
"p_dependency": 0.695
} | {
"symbol": "UBAP2L",
"name": "ubiquitin associated protein 2 like",
"family": "Small nucleolar RNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "DMS273",
"model_id": "ACH-000749",
"lineage": "Lung",
"disease": "Lung Neuroendocrine Tumor",
"subtype": "Small Cell Lung Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "UBAP2L",
"gene_metadata": {
"symbol": "UBAP2L",
"name": "ubiquitin associated protein 2 like",
"family": "Small nucleolar RNA protein coding host genes",
"ensembl_id": null
},
... |
37734cbb-eba | CCDC51 | DMS53 | ACH-000698 | essential | 1 | null | moderate | Lung | iid | {
"chronos": -0.654,
"p_dependency": 0.792
} | {
"symbol": "CCDC51",
"name": "coiled-coil domain containing 51",
"family": null,
"ensembl_id": null
} | {
"cell_name": "DMS53",
"model_id": "ACH-000698",
"lineage": "Lung",
"disease": "Lung Neuroendocrine Tumor",
"subtype": "Small Cell Lung Cancer",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_other_lineage",
"related": true,
"gene": "CCDC51",
"gene_metadata": {
"symbol": "CCDC51",
"name": "coiled-coil domain containing 51",
"family": null,
"ensembl_id": null
},
"cell": "SNU213",
"cell_metadata": {
... |
4d9ac8f4-deb | RMND5A | HSSCH2 | ACH-002066 | essential | 1 | null | rich | Peripheral Nervous System | iid | {
"chronos": -0.626,
"p_dependency": 0.856
} | {
"symbol": "RMND5A",
"name": "required for meiotic nuclear division 5 homolog A",
"family": "CTLH complex",
"ensembl_id": null
} | {
"cell_name": "HSSCH2",
"model_id": "ACH-002066",
"lineage": "Peripheral Nervous System",
"disease": "Nerve Sheath Tumor",
"subtype": "Malignant Peripheral Nerve Sheath Tumor",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "APOBEC1",
"gene_metadata": {
"symbol": "APOBEC1",
"name": "apolipoprotein B mRNA editing enzyme catalytic subunit 1",
"family": "Apolipoprotein B mRNA editing enzyme catalytic subunits",
"ensemb... |
964e7997-277 | CELF1 | KKU100 | ACH-001536 | essential | 1 | null | poor | Biliary Tract | iid | {
"chronos": -0.512,
"p_dependency": 0.531
} | {
"symbol": "CELF1",
"name": "CUGBP Elav-like family member 1",
"family": "RNA binding motif containing",
"ensembl_id": null
} | {
"cell_name": "KKU100",
"model_id": "ACH-001536",
"lineage": "Biliary Tract",
"disease": "Intraductal Papillary Neoplasm of the Bile Duct",
"subtype": "Extrahepatic Cholangiocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "CELF1",
"gene_metadata": {
"symbol": "CELF1",
"name": "CUGBP Elav-like family member 1",
"family": "RNA binding motif containing",
"ensembl_id": null
},
"cell": "CCSW1",
... |
a8cf2bf6-9a1 | ELOF1 | MORCPR | ACH-000851 | essential | 1 | null | rich | Lung | gene | {
"chronos": -0.596,
"p_dependency": 0.805
} | {
"symbol": "ELOF1",
"name": "elongation factor 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "MORCPR",
"model_id": "ACH-000851",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Unknown",
"primary_metastasis": "Primary",
"driver_mutations": [
"CTNNB1"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "GLRA1",
"gene_metadata": {
"symbol": "GLRA1",
"name": "glycine receptor alpha 1",
"family": "Glycine receptors",
"ensembl_id": null
},
"cell": "MORCPR",
"cell_metadata": {
"cel... |
a515e7b2-4ba | UBE2V1 | SW1463 | ACH-000470 | essential | 1 | null | rich | Bowel | iid | {
"chronos": -0.539,
"p_dependency": 0.644
} | {
"symbol": "UBE2V1",
"name": "ubiquitin conjugating enzyme E2 V1",
"family": "Ubiquitin conjugating enzymes E2",
"ensembl_id": null
} | {
"cell_name": "SW1463",
"model_id": "ACH-000470",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Rectal Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"FBXW7",
"OR2A5"
]
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "UBE2V1",
"gene_metadata": {
"symbol": "UBE2V1",
"name": "ubiquitin conjugating enzyme E2 V1",
"family": "Ubiquitin conjugating enzymes E2",
"ensembl_id": null
},
"cell": ... |
823b9e0a-3ba | NDUFB6 | NCIH1437 | ACH-000589 | essential | 1 | null | rich | Lung | iid | {
"chronos": -0.951,
"p_dependency": 0.985
} | {
"symbol": "NDUFB6",
"name": "NADH:ubiquinone oxidoreductase subunit B6",
"family": "NADH:ubiquinone oxidoreductase supernumerary subunits",
"ensembl_id": null
} | {
"cell_name": "NCIH1437",
"model_id": "ACH-000589",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"MAP2K1",
"TGFBR1"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "NDUFB6",
"gene_metadata": {
"symbol": "NDUFB6",
"name": "NADH:ubiquinone oxidoreductase subunit B6",
"family": "NADH:ubiquinone oxidoreductase supernumerary subunits",
"ensembl_id"... |
35830c5b-62b | HYDIN | HG3 | ACH-001520 | essential | 0 | inconclusive | poor | Lymphoid | iid | {
"chronos": -0.15,
"p_dependency": 0.071
} | {
"symbol": "HYDIN",
"name": "HYDIN axonemal central pair apparatus protein",
"family": "Protein phosphatase 1 regulatory subunits",
"ensembl_id": null
} | {
"cell_name": "HG3",
"model_id": "ACH-001520",
"lineage": "Lymphoid",
"disease": "B-Lymphoblastic Leukemia/Lymphoma",
"subtype": "B-Lymphoblastic Leukemia/Lymphoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "HYDIN",
"gene_metadata": {
"symbol": "HYDIN",
"name": "HYDIN axonemal central pair apparatus protein",
"family": "Protein phosphatase 1 regulatory subunits",
"ensembl_id": null
... |
e3cf0a0a-818 | RING1 | D425 | ACH-001053 | essential | 1 | null | poor | CNS/Brain | iid | {
"chronos": -0.539,
"p_dependency": 0.546
} | {
"symbol": "RING1",
"name": "ring finger protein 1",
"family": "Ring finger proteins",
"ensembl_id": null
} | {
"cell_name": "D425",
"model_id": "ACH-001053",
"lineage": "CNS/Brain",
"disease": "Embryonal Tumor",
"subtype": "Medulloblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "RING1",
"gene_metadata": {
"symbol": "RING1",
"name": "ring finger protein 1",
"family": "Ring finger proteins",
"ensembl_id": null
},
"cell": "LN18",
"cell_metadata": ... |
16e67f24-06d | SMARCC2 | NGP | ACH-001366 | essential | 0 | inconclusive | poor | Peripheral Nervous System | iid | {
"chronos": -0.343,
"p_dependency": 0.358
} | {
"symbol": "SMARCC2",
"name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2",
"family": "Myb/SANT domain containing|BAF complex|PBAF complex",
"ensembl_id": null
} | {
"cell_name": "NGP",
"model_id": "ACH-001366",
"lineage": "Peripheral Nervous System",
"disease": "Neuroblastoma",
"subtype": "Neuroblastoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TP53",
"PIK3CA"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "IL13",
"gene_metadata": {
"symbol": "IL13",
"name": "interleukin 13",
"family": "Interleukins",
"ensembl_id": null
},
"cell": "NGP",
"cell_metadata": {
"cell_name": "NGP",
... |
c1a847bc-634 | ATP2B1 | A3KAW | ACH-000697 | essential | 0 | inconclusive | rich | Lymphoid | iid | {
"chronos": -0.322,
"p_dependency": 0.275
} | {
"symbol": "ATP2B1",
"name": "ATPase plasma membrane Ca2+ transporting 1",
"family": "ATPases Ca2+ transporting",
"ensembl_id": null
} | {
"cell_name": "A3KAW",
"model_id": "ACH-000697",
"lineage": "Lymphoid",
"disease": "Mature B-Cell Neoplasms",
"subtype": "Diffuse Large B-Cell Lymphoma, NOS",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"MSH2"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "KRTAP10-1",
"gene_metadata": {
"symbol": "KRTAP10-1",
"name": "keratin associated protein 10-1",
"family": "Keratin associated proteins",
"ensembl_id": null
},
"cell": "A3KAW",
"cell... |
3797887b-64b | HAMP | KE39 | ACH-000507 | essential | 0 | inconclusive | moderate | Esophagus/Stomach | iid | {
"chronos": -0.05,
"p_dependency": 0.032
} | {
"symbol": "HAMP",
"name": "hepcidin antimicrobial peptide",
"family": null,
"ensembl_id": null
} | {
"cell_name": "KE39",
"model_id": "ACH-000507",
"lineage": "Esophagus/Stomach",
"disease": "Esophagogastric Adenocarcinoma",
"subtype": "Stomach Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"CTNNB1"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "RNF17",
"gene_metadata": {
"symbol": "RNF17",
"name": "ring finger protein 17",
"family": "Ring finger proteins|Tudor domain containing",
"ensembl_id": null
},
"cell": "KE39",
"cell_... |
4049aa95-d55 | COX6C | RPMI2650 | ACH-001385 | essential | 1 | null | rich | Head and Neck | iid | {
"chronos": -0.71,
"p_dependency": 0.903
} | {
"symbol": "COX6C",
"name": "cytochrome c oxidase subunit 6C",
"family": "Mitochondrial complex IV: cytochrome c oxidase subunits",
"ensembl_id": null
} | {
"cell_name": "RPMI2650",
"model_id": "ACH-001385",
"lineage": "Head and Neck",
"disease": "Head and Neck Carcinoma, Other",
"subtype": "NUT Midline Carcinoma of the Head and Neck",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "COX6C",
"gene_metadata": {
"symbol": "COX6C",
"name": "cytochrome c oxidase subunit 6C",
"family": "Mitochondrial complex IV: cytochrome c oxidase subunits",
"ensembl_id": null
... |
d7a46f6a-825 | C16orf86 | WERIRB1 | ACH-001421 | essential | 1 | null | poor | Eye | iid | {
"chronos": -0.729,
"p_dependency": 0.748
} | {
"symbol": "C16orf86",
"name": "chromosome 16 open reading frame 86",
"family": null,
"ensembl_id": null
} | {
"cell_name": "WERIRB1",
"model_id": "ACH-001421",
"lineage": "Eye",
"disease": "Retinoblastoma",
"subtype": "Retinoblastoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_other_lineage",
"related": true,
"gene": "C16orf86",
"gene_metadata": {
"symbol": "C16orf86",
"name": "chromosome 16 open reading frame 86",
"family": null,
"ensembl_id": null
},
"cell": "SNU840",
"cell_metada... |
03f40109-6ca | BAZ1B | SKGIIIA | ACH-002020 | essential | 0 | inconclusive | rich | Cervix | lineage | {
"chronos": -0.435,
"p_dependency": 0.563
} | {
"symbol": "BAZ1B",
"name": "bromodomain adjacent to zinc finger domain 1B",
"family": "PHD finger proteins|Bromodomain containing|B-WICH chromatin-remodelling complex subunits",
"ensembl_id": null
} | {
"cell_name": "SKGIIIA",
"model_id": "ACH-002020",
"lineage": "Cervix",
"disease": "Cervical Squamous Cell Carcinoma",
"subtype": "Cervical Squamous Cell Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"TP53",
"NFE2L2",
"HLA-A"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "OR56B1",
"gene_metadata": {
"symbol": "OR56B1",
"name": "olfactory receptor family 56 subfamily B member 1",
"family": "Olfactory receptors, family 56",
"ensembl_id": null
},
"cell": "SK... |
aacbc1c0-9d2 | OR51I2 | MEL290 | ACH-002016 | essential | 0 | inconclusive | poor | Eye | iid | {
"chronos": -0.314,
"p_dependency": 0.252
} | {
"symbol": "OR51I2",
"name": "olfactory receptor family 51 subfamily I member 2",
"family": "Olfactory receptors, family 51",
"ensembl_id": null
} | {
"cell_name": "MEL290",
"model_id": "ACH-002016",
"lineage": "Eye",
"disease": "Ocular Melanoma",
"subtype": "Uveal Melanoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "KRTAP10-10",
"gene_metadata": {
"symbol": "KRTAP10-10",
"name": "keratin associated protein 10-10",
"family": "Keratin associated proteins",
"ensembl_id": null
},
"cell": "MEL290",
"... |
5221150c-bfe | EED | ROS50 | ACH-001639 | essential | 0 | refuted | rich | Lymphoid | gene | {
"chronos": 0.955,
"p_dependency": 0
} | {
"symbol": "EED",
"name": "embryonic ectoderm development",
"family": "WD repeat domain containing|Polycomb repressive complex 2|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "ROS50",
"model_id": "ACH-001639",
"lineage": "Lymphoid",
"disease": "Mature B-Cell Neoplasms",
"subtype": "Diffuse Large B-Cell Lymphoma, NOS",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TP53",
"EZH2",
"MYC"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "EED",
"gene_metadata": {
"symbol": "EED",
"name": "embryonic ectoderm development",
"family": "WD repeat domain containing|Polycomb repressive complex 2|MicroRNA protein coding host gene... |
5407b08f-767 | CRAMP1 | LB1047RCC | ACH-002150 | essential | 1 | null | moderate | Kidney | iid | {
"chronos": -0.541,
"p_dependency": 0.795
} | {
"symbol": "CRAMP1",
"name": "cramped chromatin regulator homolog 1",
"family": "Myb/SANT domain containing",
"ensembl_id": null
} | {
"cell_name": "LB1047RCC",
"model_id": "ACH-002150",
"lineage": "Kidney",
"disease": "Renal Cell Carcinoma",
"subtype": "Renal Cell Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "MEP1A",
"gene_metadata": {
"symbol": "MEP1A",
"name": "meprin A subunit alpha",
"family": "Astacins",
"ensembl_id": null
},
"cell": "LB1047RCC",
"cell_metadata": {
"cell_name":... |
d358d6e8-1fc | PDHA1 | UCH2 | ACH-002204 | essential | 0 | refuted | poor | Bone | iid | {
"chronos": 0.29,
"p_dependency": 0.002
} | {
"symbol": "PDHA1",
"name": "pyruvate dehydrogenase E1 subunit alpha 1",
"family": "Pyruvate dehydrogenase complex",
"ensembl_id": null
} | {
"cell_name": "UCH2",
"model_id": "ACH-002204",
"lineage": "Bone",
"disease": "Chordoma",
"subtype": "Chordoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"PCDH18"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "PDHA1",
"gene_metadata": {
"symbol": "PDHA1",
"name": "pyruvate dehydrogenase E1 subunit alpha 1",
"family": "Pyruvate dehydrogenase complex",
"ensembl_id": null
},
"cell": "UCH... |
070fc603-ffd | API5 | NCIH716 | ACH-000491 | essential | 0 | inconclusive | poor | Bowel | iid | {
"chronos": -0.239,
"p_dependency": 0.119
} | {
"symbol": "API5",
"name": "apoptosis inhibitor 5",
"family": "Armadillo like helical domain containing",
"ensembl_id": null
} | {
"cell_name": "NCIH716",
"model_id": "ACH-000491",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Colon Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "API5",
"gene_metadata": {
"symbol": "API5",
"name": "apoptosis inhibitor 5",
"family": "Armadillo like helical domain containing",
"ensembl_id": null
},
"cell": "KM12",
... |
bf799ef6-2ed | ALAS1 | TGBC1TKB | ACH-001861 | essential | 1 | null | moderate | Biliary Tract | iid | {
"chronos": -0.648,
"p_dependency": 0.852
} | {
"symbol": "ALAS1",
"name": "5'-aminolevulinate synthase 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "TGBC1TKB",
"model_id": "ACH-001861",
"lineage": "Biliary Tract",
"disease": "Intracholecystic Papillary Neoplasm",
"subtype": "Gallbladder Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "LALBA",
"gene_metadata": {
"symbol": "LALBA",
"name": "lactalbumin alpha",
"family": "Lysozymes, c-type",
"ensembl_id": null
},
"cell": "TGBC1TKB",
"cell_metadata": {
"cell_nam... |
a378e446-b3e | TFAP4 | EOL1 | ACH-000198 | essential | 1 | null | rich | Myeloid | iid | {
"chronos": -0.802,
"p_dependency": 0.973
} | {
"symbol": "TFAP4",
"name": "transcription factor AP-4",
"family": "Basic helix-loop-helix proteins",
"ensembl_id": null
} | {
"cell_name": "EOL1",
"model_id": "ACH-000198",
"lineage": "Myeloid",
"disease": "Myeloproliferative Neoplasms",
"subtype": "Chronic Eosinophilic Leukemia, NOS",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CB"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "TFAP4",
"gene_metadata": {
"symbol": "TFAP4",
"name": "transcription factor AP-4",
"family": "Basic helix-loop-helix proteins",
"ensembl_id": null
},
"cell": "EOL1",
"cell_m... |
ea31f3d6-71f | FEM1B | SCC3 | ACH-001642 | essential | 0 | inconclusive | poor | Lymphoid | gene | {
"chronos": -0.335,
"p_dependency": 0.251
} | {
"symbol": "FEM1B",
"name": "fem-1 homolog B",
"family": "Ankyrin repeat domain containing",
"ensembl_id": null
} | {
"cell_name": "SCC3",
"model_id": "ACH-001642",
"lineage": "Lymphoid",
"disease": "Non-Hodgkin Lymphoma",
"subtype": "Mature B-Cell Neoplasms",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"MAP2K1"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "ZG16",
"gene_metadata": {
"symbol": "ZG16",
"name": "zymogen granule protein 16",
"family": null,
"ensembl_id": null
},
"cell": "SCC3",
"cell_metadata": {
"cell_name": "SCC3",
... |
13a88ee0-c23 | HMGN2 | C99 | ACH-001461 | essential | 1 | null | rich | Bowel | iid | {
"chronos": -0.65,
"p_dependency": 0.688
} | {
"symbol": "HMGN2",
"name": "high mobility group nucleosomal binding domain 2",
"family": "Canonical high mobility group",
"ensembl_id": null
} | {
"cell_name": "C99",
"model_id": "ACH-001461",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Rectal Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "HMGN2",
"gene_metadata": {
"symbol": "HMGN2",
"name": "high mobility group nucleosomal binding domain 2",
"family": "Canonical high mobility group",
"ensembl_id": null
},
"... |
4375e012-0db | P3H1 | TE1 | ACH-000647 | essential | 0 | inconclusive | poor | Esophagus/Stomach | iid | {
"chronos": -0.264,
"p_dependency": 0.256
} | {
"symbol": "P3H1",
"name": "prolyl 3-hydroxylase 1",
"family": "Prolyl 3-hydroxylase family",
"ensembl_id": null
} | {
"cell_name": "TE1",
"model_id": "ACH-000647",
"lineage": "Esophagus/Stomach",
"disease": "Esophageal Squamous Cell Carcinoma",
"subtype": "Esophageal Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "P3H1",
"gene_metadata": {
"symbol": "P3H1",
"name": "prolyl 3-hydroxylase 1",
"family": "Prolyl 3-hydroxylase family",
"ensembl_id": null
},
"cell": "TE1",
"cell_meta... |
6527d9b3-7a2 | TMCO6 | JHH6 | ACH-000217 | essential | 1 | null | moderate | Liver | iid | {
"chronos": -0.834,
"p_dependency": 0.958
} | {
"symbol": "TMCO6",
"name": "transmembrane and coiled-coil domains 6",
"family": "Armadillo like helical domain containing",
"ensembl_id": null
} | {
"cell_name": "JHH6",
"model_id": "ACH-000217",
"lineage": "Liver",
"disease": "Hepatocellular Carcinoma",
"subtype": "Hepatocellular Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "TMCO6",
"gene_metadata": {
"symbol": "TMCO6",
"name": "transmembrane and coiled-coil domains 6",
"family": "Armadillo like helical domain containing",
"ensembl_id": null
},
... |
4c79a456-240 | HDAC8 | TO14 | ACH-001403 | essential | 0 | inconclusive | poor | Ovary/Fallopian Tube | iid | {
"chronos": 0.122,
"p_dependency": 0.014
} | {
"symbol": "HDAC8",
"name": "histone deacetylase 8",
"family": "Histone deacetylases, class I",
"ensembl_id": null
} | {
"cell_name": "TO14",
"model_id": "ACH-001403",
"lineage": "Ovary/Fallopian Tube",
"disease": "Ovarian Epithelial Tumor",
"subtype": "Serous Ovarian Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"CREBBP"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "HDAC8",
"gene_metadata": {
"symbol": "HDAC8",
"name": "histone deacetylase 8",
"family": "Histone deacetylases, class I",
"ensembl_id": null
},
"cell": "NIHOVCAR3",
"ce... |
6b4c5cd2-403 | TADA2B | JR | ACH-001096 | essential | 1 | null | moderate | Soft Tissue | iid | {
"chronos": -0.661,
"p_dependency": 0.879
} | {
"symbol": "TADA2B",
"name": "transcriptional adaptor 2B",
"family": "Zinc fingers ZZ-type|Myb/SANT domain containing|SAGA complex",
"ensembl_id": null
} | {
"cell_name": "JR",
"model_id": "ACH-001096",
"lineage": "Soft Tissue",
"disease": "Rhabdomyosarcoma",
"subtype": "Alveolar Rhabdomyosarcoma",
"sex": "Unknown",
"primary_metastasis": null,
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "TADA2B",
"gene_metadata": {
"symbol": "TADA2B",
"name": "transcriptional adaptor 2B",
"family": "Zinc fingers ZZ-type|Myb/SANT domain containing|SAGA complex",
"ensembl_id": null
... |
b974aeae-f97 | OTUB1 | ES4 | ACH-002105 | essential | 0 | inconclusive | moderate | Bone | iid | {
"chronos": -0.128,
"p_dependency": 0.057
} | {
"symbol": "OTUB1",
"name": "OTU deubiquitinase, ubiquitin aldehyde binding 1",
"family": "OTU domain containing",
"ensembl_id": null
} | {
"cell_name": "ES4",
"model_id": "ACH-002105",
"lineage": "Bone",
"disease": "Ewing Sarcoma",
"subtype": "Ewing Sarcoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CA",
"RAC1"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "OTUB1",
"gene_metadata": {
"symbol": "OTUB1",
"name": "OTU deubiquitinase, ubiquitin aldehyde binding 1",
"family": "OTU domain containing",
"ensembl_id": null
},
"cell": "ES4",... |
b966a880-ff0 | LRRC57 | NCIH2291 | ACH-000718 | essential | 0 | inconclusive | poor | Lung | gene | {
"chronos": 0.068,
"p_dependency": 0.018
} | {
"symbol": "LRRC57",
"name": "leucine rich repeat containing 57",
"family": null,
"ensembl_id": null
} | {
"cell_name": "NCIH2291",
"model_id": "ACH-000718",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "LRRC57",
"gene_metadata": {
"symbol": "LRRC57",
"name": "leucine rich repeat containing 57",
"family": null,
"ensembl_id": null
},
"cell": "NCIH2291",
"cell_metadata": {
... |
a884e68d-36b | PPA2 | L33 | ACH-000685 | essential | 1 | null | rich | Pancreas | iid | {
"chronos": -0.855,
"p_dependency": 0.963
} | {
"symbol": "PPA2",
"name": "inorganic pyrophosphatase 2",
"family": null,
"ensembl_id": null
} | {
"cell_name": "L33",
"model_id": "ACH-000685",
"lineage": "Pancreas",
"disease": "Adenosquamous Carcinoma of the Pancreas",
"subtype": "Adenosquamous Carcinoma of the Pancreas",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"KRAS",
"SMAD4"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "DMP1",
"gene_metadata": {
"symbol": "DMP1",
"name": "dentin matrix acidic phosphoprotein 1",
"family": "SIBLING family",
"ensembl_id": null
},
"cell": "L33",
"cell_metadata": {
... |
e7fb472d-6d2 | MTF1 | JJN3 | ACH-000653 | essential | 0 | inconclusive | moderate | Lymphoid | iid | {
"chronos": -0.446,
"p_dependency": 0.59
} | {
"symbol": "MTF1",
"name": "metal regulatory transcription factor 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "JJN3",
"model_id": "ACH-000653",
"lineage": "Lymphoid",
"disease": "Mature B-Cell Neoplasms",
"subtype": "Plasma Cell Myeloma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "MTF1",
"gene_metadata": {
"symbol": "MTF1",
"name": "metal regulatory transcription factor 1",
"family": null,
"ensembl_id": null
},
"cell": "TANOUE",
"cell_metadata": ... |
b4b2c966-0c3 | CTDSPL2 | BIN67 | ACH-001278 | essential | 0 | inconclusive | moderate | Ovary/Fallopian Tube | iid | {
"chronos": -0.469,
"p_dependency": 0.594
} | {
"symbol": "CTDSPL2",
"name": "CTD small phosphatase like 2",
"family": "CTD family phosphatases",
"ensembl_id": null
} | {
"cell_name": "BIN67",
"model_id": "ACH-001278",
"lineage": "Ovary/Fallopian Tube",
"disease": "Ovarian Epithelial Tumor",
"subtype": "Small Cell Carcinoma of the Ovary",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "HTR5A",
"gene_metadata": {
"symbol": "HTR5A",
"name": "5-hydroxytryptamine receptor 5A",
"family": "5-hydroxytryptamine receptors, G protein-coupled",
"ensembl_id": null
},
"cell": "BIN6... |
d61191a9-4e0 | TEN1 | SEMK2 | ACH-001735 | essential | 1 | null | rich | Lymphoid | gene | {
"chronos": -0.795,
"p_dependency": 0.925
} | {
"symbol": "TEN1",
"name": "TEN1 subunit of CST complex",
"family": "CST complex",
"ensembl_id": null
} | {
"cell_name": "SEMK2",
"model_id": "ACH-001735",
"lineage": "Lymphoid",
"disease": "B-Lymphoblastic Leukemia/Lymphoma",
"subtype": "B-Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3);KMT2A Rearranged",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"TP53",
"ANKRD40",
... | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "TEN1",
"gene_metadata": {
"symbol": "TEN1",
"name": "TEN1 subunit of CST complex",
"family": "CST complex",
"ensembl_id": null
},
"cell": "SEMK2",
"cell_metadata": {
... |
830e0f80-31a | TSGA10 | MM485 | ACH-001973 | essential | 0 | inconclusive | poor | Skin | iid | {
"chronos": -0.198,
"p_dependency": 0.089
} | {
"symbol": "TSGA10",
"name": "testis specific 10",
"family": null,
"ensembl_id": null
} | {
"cell_name": "MM485",
"model_id": "ACH-001973",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"NRAS",
"TP63",
"TERT"
]
} | [
{
"modality": "mutation",
"context_type": "molecular_mutation",
"related": true,
"gene": "TSGA10",
"gene_metadata": {
"symbol": "TSGA10",
"name": "testis specific 10",
"family": null,
"ensembl_id": null
},
"cell": "MM485",
"cell_metadata": {
"cell_name":... |
ea5de50a-321 | AMBRA1 | RCM1 | ACH-000565 | essential | 0 | refuted | moderate | Bowel | iid | {
"chronos": 0.268,
"p_dependency": 0.003
} | {
"symbol": "AMBRA1",
"name": "autophagy and beclin 1 regulator 1",
"family": "WD repeat domain containing|DDB1 and CUL4 associated factors|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "RCM1",
"model_id": "ACH-000565",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Rectal Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"FBXW7",
"APC"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "SLC39A12",
"gene_metadata": {
"symbol": "SLC39A12",
"name": "solute carrier family 39 member 12",
"family": "Solute carrier family 39 ",
"ensembl_id": null
},
"cell": "RCM1",
"cell_m... |
825dded2-d43 | PDHB | CW9019 | ACH-001050 | essential | 0 | refuted | poor | Soft Tissue | iid | {
"chronos": 0.283,
"p_dependency": 0.005
} | {
"symbol": "PDHB",
"name": "pyruvate dehydrogenase E1 subunit beta",
"family": "Pyruvate dehydrogenase complex",
"ensembl_id": null
} | {
"cell_name": "CW9019",
"model_id": "ACH-001050",
"lineage": "Soft Tissue",
"disease": "Rhabdomyosarcoma",
"subtype": "Alveolar Rhabdomyosarcoma",
"sex": "Male",
"primary_metastasis": null,
"driver_mutations": []
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "PDHB",
"gene_metadata": {
"symbol": "PDHB",
"name": "pyruvate dehydrogenase E1 subunit beta",
"family": "Pyruvate dehydrogenase complex",
"ensembl_id": null
},
"cell": "CW9019",... |
d3813966-d09 | FANCC | SKES1 | ACH-000087 | essential | 0 | inconclusive | poor | Bone | iid | {
"chronos": -0.351,
"p_dependency": 0.307
} | {
"symbol": "FANCC",
"name": "FA complementation group C",
"family": "FA complementation groups|FA core complex",
"ensembl_id": null
} | {
"cell_name": "SKES1",
"model_id": "ACH-000087",
"lineage": "Bone",
"disease": "Ewing Sarcoma",
"subtype": "Ewing Sarcoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "FANCC",
"gene_metadata": {
"symbol": "FANCC",
"name": "FA complementation group C",
"family": "FA complementation groups|FA core complex",
"ensembl_id": null
},
"cell": "ES... |
8c3aada9-a8d | ZNF273 | SW1116 | ACH-000489 | essential | 0 | inconclusive | moderate | Bowel | iid | {
"chronos": -0.161,
"p_dependency": 0.135
} | {
"symbol": "ZNF273",
"name": "zinc finger protein 273",
"family": "Zinc fingers C2H2-type",
"ensembl_id": null
} | {
"cell_name": "SW1116",
"model_id": "ACH-000489",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Colon Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS",
"PTCH1"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "ZNF273",
"gene_metadata": {
"symbol": "ZNF273",
"name": "zinc finger protein 273",
"family": "Zinc fingers C2H2-type",
"ensembl_id": null
},
"cell": "DLD1",
"cell_metad... |
12dbdd3f-1b8 | INTS14 | L363 | ACH-000183 | essential | 1 | null | rich | Lymphoid | iid | {
"chronos": -0.635,
"p_dependency": 0.839
} | {
"symbol": "INTS14",
"name": "integrator complex subunit 14",
"family": "Integrator complex",
"ensembl_id": null
} | {
"cell_name": "L363",
"model_id": "ACH-000183",
"lineage": "Lymphoid",
"disease": "Mature B-Cell Neoplasms",
"subtype": "Plasma Cell Myeloma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CA"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "INTS14",
"gene_metadata": {
"symbol": "INTS14",
"name": "integrator complex subunit 14",
"family": "Integrator complex",
"ensembl_id": null
},
"cell": "FARAGE",
"cell_m... |
f15187f0-fe4 | HMGN1 | HCC44 | ACH-000667 | essential | 0 | inconclusive | moderate | Lung | iid | {
"chronos": -0.199,
"p_dependency": 0.153
} | {
"symbol": "HMGN1",
"name": "high mobility group nucleosome binding domain 1",
"family": "Canonical high mobility group",
"ensembl_id": null
} | {
"cell_name": "HCC44",
"model_id": "ACH-000667",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "POU4F3",
"gene_metadata": {
"symbol": "POU4F3",
"name": "POU class 4 homeobox 3",
"family": "POU class homeoboxes and pseudogenes",
"ensembl_id": null
},
"cell": "HCC44",
"cell_metad... |
20ef1f01-0cd | MRM3 | UMUC1 | ACH-000834 | essential | 1 | null | moderate | Bladder/Urinary Tract | iid | {
"chronos": -0.637,
"p_dependency": 0.869
} | {
"symbol": "MRM3",
"name": "mitochondrial rRNA methyltransferase 3",
"family": "SPOUT methyltransferase domain containing",
"ensembl_id": null
} | {
"cell_name": "UMUC1",
"model_id": "ACH-000834",
"lineage": "Bladder/Urinary Tract",
"disease": "Bladder Urothelial Carcinoma",
"subtype": "Bladder Urothelial Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"ZNF648"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "OR5T3",
"gene_metadata": {
"symbol": "OR5T3",
"name": "olfactory receptor family 5 subfamily T member 3",
"family": "Olfactory receptors, family 5",
"ensembl_id": null
},
"cell": "UMUC1"... |
bde1c928-c91 | TCF7L2 | NCCCCS1BC1 | ACH-002792 | essential | 0 | inconclusive | moderate | Soft Tissue | iid | {
"chronos": -0.207,
"p_dependency": 0.156
} | {
"symbol": "TCF7L2",
"name": "transcription factor 7 like 2",
"family": "TCF/LEF transcription factor family|Wnt enhanceosome complex",
"ensembl_id": null
} | {
"cell_name": "NCCCCS1BC1",
"model_id": "ACH-002792",
"lineage": "Soft Tissue",
"disease": "Clear Cell Sarcoma",
"subtype": "Clear Cell Sarcoma",
"sex": "Female",
"primary_metastasis": "Unknown",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "TCF7L2",
"gene_metadata": {
"symbol": "TCF7L2",
"name": "transcription factor 7 like 2",
"family": "TCF/LEF transcription factor family|Wnt enhanceosome complex",
"ensembl_id": n... |
9592a374-56b | MYO18A | KM12 | ACH-000969 | essential | 0 | inconclusive | moderate | Bowel | iid | {
"chronos": -0.159,
"p_dependency": 0.083
} | {
"symbol": "MYO18A",
"name": "myosin XVIIIA",
"family": "Myosin heavy chains, class XVIII|PDZ domain containing",
"ensembl_id": null
} | {
"cell_name": "KM12",
"model_id": "ACH-000969",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Colon Adenocarcinoma",
"sex": "Unknown",
"primary_metastasis": "Primary",
"driver_mutations": [
"TP53",
"GNAS"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "ADAM18",
"gene_metadata": {
"symbol": "ADAM18",
"name": "ADAM metallopeptidase domain 18",
"family": "ADAM metallopeptidase domain containing",
"ensembl_id": null
},
"cell": "KM12",
... |
b5b0d272-9aa | ATP2C1 | UMUC14 | ACH-001408 | essential | 0 | inconclusive | poor | Bladder/Urinary Tract | iid | {
"chronos": 0.25,
"p_dependency": 0.002
} | {
"symbol": "ATP2C1",
"name": "ATPase secretory pathway Ca2+ transporting 1",
"family": "ATPases Ca2+ transporting",
"ensembl_id": null
} | {
"cell_name": "UMUC14",
"model_id": "ACH-001408",
"lineage": "Bladder/Urinary Tract",
"disease": "Urethral Cancer",
"subtype": "Urethral Urothelial Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "CLCA1",
"gene_metadata": {
"symbol": "CLCA1",
"name": "chloride channel accessory 1",
"family": "Chloride channel accessory",
"ensembl_id": null
},
"cell": "UMUC14",
"cell_metadata":... |
113f3034-84a | CARS2 | D423MG | ACH-002228 | essential | 1 | null | rich | CNS/Brain | iid | {
"chronos": -0.747,
"p_dependency": 0.951
} | {
"symbol": "CARS2",
"name": "cysteinyl-tRNA synthetase 2, mitochondrial",
"family": "Aminoacyl tRNA synthetases, Class I",
"ensembl_id": null
} | {
"cell_name": "D423MG",
"model_id": "ACH-002228",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Glioblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "CARS2",
"gene_metadata": {
"symbol": "CARS2",
"name": "cysteinyl-tRNA synthetase 2, mitochondrial",
"family": "Aminoacyl tRNA synthetases, Class I",
"ensembl_id": null
},
"... |
0238e6c0-141 | TMEM276 | RT4 | ACH-000242 | essential | 0 | inconclusive | moderate | Bladder/Urinary Tract | iid | {
"chronos": -0.145,
"p_dependency": 0.056
} | {
"symbol": "TMEM276",
"name": "transmembrane protein 276",
"family": null,
"ensembl_id": null
} | {
"cell_name": "RT4",
"model_id": "ACH-000242",
"lineage": "Bladder/Urinary Tract",
"disease": "Bladder Urothelial Carcinoma",
"subtype": "Bladder Urothelial Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "TMEM276",
"gene_metadata": {
"symbol": "TMEM276",
"name": "transmembrane protein 276",
"family": null,
"ensembl_id": null
},
"cell": "UMUC11",
"cell_metadata": {
... |
751c23d1-a8e | PRKAG1 | 9505BIK | ACH-001999 | essential | 0 | inconclusive | moderate | Pancreas | iid | {
"chronos": -0.185,
"p_dependency": 0.134
} | {
"symbol": "PRKAG1",
"name": "protein kinase AMP-activated non-catalytic subunit gamma 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "9505BIK",
"model_id": "ACH-001999",
"lineage": "Pancreas",
"disease": "Pancreatic Adenocarcinoma",
"subtype": "Pancreatic Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS",
"ERBB3",
"GNAS"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "PRKAG1",
"gene_metadata": {
"symbol": "PRKAG1",
"name": "protein kinase AMP-activated non-catalytic subunit gamma 1",
"family": null,
"ensembl_id": null
},
"cell": "9505BIK",
... |
7dbab6af-1eb | UQCR11 | KYSE70 | ACH-000784 | essential | 0 | inconclusive | moderate | Esophagus/Stomach | iid | {
"chronos": -0.36,
"p_dependency": 0.371
} | {
"symbol": "UQCR11",
"name": "ubiquinol-cytochrome c reductase, complex III subunit XI",
"family": "Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits",
"ensembl_id": null
} | {
"cell_name": "KYSE70",
"model_id": "ACH-000784",
"lineage": "Esophagus/Stomach",
"disease": "Esophageal Squamous Cell Carcinoma",
"subtype": "Esophageal Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TP53"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "UQCR11",
"gene_metadata": {
"symbol": "UQCR11",
"name": "ubiquinol-cytochrome c reductase, complex III subunit XI",
"family": "Mitochondrial complex III: ubiquinol-cytochrome c reductase... |
2f4e1f6b-022 | PDCD6IP | HCA1 | ACH-001513 | essential | 1 | null | rich | Cervix | lineage | {
"chronos": -0.518,
"p_dependency": 0.622
} | {
"symbol": "PDCD6IP",
"name": "programmed cell death 6 interacting protein",
"family": null,
"ensembl_id": null
} | {
"cell_name": "HCA1",
"model_id": "ACH-001513",
"lineage": "Cervix",
"disease": "Cervical Adenocarcinoma",
"subtype": "Endocervical Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TPTE"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "PDCD6IP",
"gene_metadata": {
"symbol": "PDCD6IP",
"name": "programmed cell death 6 interacting protein",
"family": null,
"ensembl_id": null
},
"cell": "SF767",
"cell_me... |
bdf2a809-fdb | ARHGAP45 | HCC515 | ACH-000872 | essential | 0 | inconclusive | poor | Lung | iid | {
"chronos": 0.101,
"p_dependency": 0.008
} | {
"symbol": "ARHGAP45",
"name": "Rho GTPase activating protein 45",
"family": "Minor histocompatibility antigens|F-BAR domain containing |AH/BAR family Rho GTPase activating proteins",
"ensembl_id": null
} | {
"cell_name": "HCC515",
"model_id": "ACH-000872",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "ARHGAP45",
"gene_metadata": {
"symbol": "ARHGAP45",
"name": "Rho GTPase activating protein 45",
"family": "Minor histocompatibility antigens|F-BAR domain containing |AH/BAR family Rho GT... |
1a6bbd57-bc6 | MALL | OSRC2 | ACH-000159 | essential | 0 | inconclusive | poor | Kidney | iid | {
"chronos": -0.204,
"p_dependency": 0.15
} | {
"symbol": "MALL",
"name": "mal, T cell differentiation protein like",
"family": "MARVEL domain containing|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "OSRC2",
"model_id": "ACH-000159",
"lineage": "Kidney",
"disease": "Renal Cell Carcinoma",
"subtype": "Renal Clear Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "STATH",
"gene_metadata": {
"symbol": "STATH",
"name": "statherin",
"family": "Histatins and statherin|Secretory calcium-binding phosphoprotein family",
"ensembl_id": null
},
"cell": "OSR... |
0928c859-4e3 | DDX31 | RPMI7951 | ACH-000348 | essential | 0 | inconclusive | moderate | Skin | iid | {
"chronos": -0.278,
"p_dependency": 0.329
} | {
"symbol": "DDX31",
"name": "DEAD-box helicase 31",
"family": "DEAD-box helicases|Protein phosphatase 1 regulatory subunits",
"ensembl_id": null
} | {
"cell_name": "RPMI7951",
"model_id": "ACH-000348",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"BRAF"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "DDX31",
"gene_metadata": {
"symbol": "DDX31",
"name": "DEAD-box helicase 31",
"family": "DEAD-box helicases|Protein phosphatase 1 regulatory subunits",
"ensembl_id": null
},
"ce... |
c5e6a081-521 | DPPA3 | CAS1 | ACH-000464 | essential | 1 | null | poor | CNS/Brain | iid | {
"chronos": -0.505,
"p_dependency": 0.565
} | {
"symbol": "DPPA3",
"name": "developmental pluripotency associated 3",
"family": null,
"ensembl_id": null
} | {
"cell_name": "CAS1",
"model_id": "ACH-000464",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Glioblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "OR8B8",
"gene_metadata": {
"symbol": "OR8B8",
"name": "olfactory receptor family 8 subfamily B member 8",
"family": "Olfactory receptors, family 8",
"ensembl_id": null
},
"cell": "CAS1",... |
59055d63-6d1 | NFE2L2 | WM1799 | ACH-000661 | essential | 0 | refuted | moderate | Skin | iid | {
"chronos": 0.291,
"p_dependency": 0
} | {
"symbol": "NFE2L2",
"name": "NFE2 like bZIP transcription factor 2",
"family": "Basic leucine zipper proteins|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "WM1799",
"model_id": "ACH-000661",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "NFE2L2",
"gene_metadata": {
"symbol": "NFE2L2",
"name": "NFE2 like bZIP transcription factor 2",
"family": "Basic leucine zipper proteins|MicroRNA protein coding host genes",
"ensembl_i... |
57a5a13a-8c0 | STEAP3 | ISTMEL1 | ACH-002143 | essential | 0 | inconclusive | poor | Skin | iid | {
"chronos": -0.192,
"p_dependency": 0.165
} | {
"symbol": "STEAP3",
"name": "STEAP3 metalloreductase",
"family": "STEAP family|Flavoproteins",
"ensembl_id": null
} | {
"cell_name": "ISTMEL1",
"model_id": "ACH-002143",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"BRAF",
"CDKN2A"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "STEAP3",
"gene_metadata": {
"symbol": "STEAP3",
"name": "STEAP3 metalloreductase",
"family": "STEAP family|Flavoproteins",
"ensembl_id": null
},
"cell": "ISTMEL1",
"cell_met... |
a300044f-cca | SECISBP2 | COV362 | ACH-000278 | essential | 0 | inconclusive | poor | Ovary/Fallopian Tube | iid | {
"chronos": -0.056,
"p_dependency": 0.029
} | {
"symbol": "SECISBP2",
"name": "SECIS binding protein 2",
"family": null,
"ensembl_id": null
} | {
"cell_name": "COV362",
"model_id": "ACH-000278",
"lineage": "Ovary/Fallopian Tube",
"disease": "Ovarian Epithelial Tumor",
"subtype": "High-Grade Serous Ovarian Cancer",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "pharmacology",
"context_type": "pharmacology",
"related": true,
"gene": "GPX4",
"gene_metadata": {
"symbol": "GPX4",
"name": "glutathione peroxidase 4",
"family": "Selenoproteins",
"ensembl_id": null
},
"cell": "COV362",
"cell_metadata": {
... |
d13d1ce0-8b9 | C1QTNF4 | CCK81 | ACH-000963 | essential | 0 | refuted | moderate | Bowel | gene | {
"chronos": 0.39,
"p_dependency": 0.002
} | {
"symbol": "C1QTNF4",
"name": "C1q and TNF related 4",
"family": "C1q and TNF related ",
"ensembl_id": null
} | {
"cell_name": "CCK81",
"model_id": "ACH-000963",
"lineage": "Bowel",
"disease": "Colorectal Adenocarcinoma",
"subtype": "Colon Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"ZNF648",
"TP53",
"LZTR1"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "TSPO2",
"gene_metadata": {
"symbol": "TSPO2",
"name": "translocator protein 2",
"family": null,
"ensembl_id": null
},
"cell": "CCK81",
"cell_metadata": {
"cell_name": "CCK81",
... |
9559f21b-82f | RBM10 | UBLC1 | ACH-000741 | essential | 1 | null | rich | Bladder/Urinary Tract | iid | {
"chronos": -0.647,
"p_dependency": 0.81
} | {
"symbol": "RBM10",
"name": "RNA binding motif protein 10",
"family": "Zinc fingers RANBP2-type |G-patch domain containing|RNA binding motif containing|Spliceosomal A complex",
"ensembl_id": null
} | {
"cell_name": "UBLC1",
"model_id": "ACH-000741",
"lineage": "Bladder/Urinary Tract",
"disease": "Bladder Urothelial Carcinoma",
"subtype": "Bladder Urothelial Carcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"CGAS"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "RBM10",
"gene_metadata": {
"symbol": "RBM10",
"name": "RNA binding motif protein 10",
"family": "Zinc fingers RANBP2-type |G-patch domain containing|RNA binding motif containing|Spliceos... |
a579e27b-472 | AP1B1 | TFK1 | ACH-001673 | essential | 0 | inconclusive | poor | Biliary Tract | iid | {
"chronos": -0.032,
"p_dependency": 0.028
} | {
"symbol": "AP1B1",
"name": "adaptor related protein complex 1 subunit beta 1",
"family": "Clathrin/coatomer adaptor, adaptin-like, N-terminal domain containing|Adaptor related protein complex 1|MicroRNA protein coding host genes|Small nucleolar RNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "TFK1",
"model_id": "ACH-001673",
"lineage": "Biliary Tract",
"disease": "Intraductal Papillary Neoplasm of the Bile Duct",
"subtype": "Extrahepatic Cholangiocarcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "HCRTR2",
"gene_metadata": {
"symbol": "HCRTR2",
"name": "hypocretin receptor 2",
"family": "Hypocretin receptors",
"ensembl_id": null
},
"cell": "TFK1",
"cell_metadata": {
"cel... |
7be2c0a1-b28 | ITSN2 | LPS853 | ACH-001802 | essential | 0 | inconclusive | poor | Soft Tissue | iid | {
"chronos": -0.018,
"p_dependency": 0.035
} | {
"symbol": "ITSN2",
"name": "intersectin 2",
"family": "Dbl family Rho GEFs|C2 domain containing|EF-hand domain containing",
"ensembl_id": null
} | {
"cell_name": "LPS853",
"model_id": "ACH-001802",
"lineage": "Soft Tissue",
"disease": "Liposarcoma",
"subtype": "Dedifferentiated Liposarcoma",
"sex": "Unknown",
"primary_metastasis": null,
"driver_mutations": [
"KEAP1"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "NLRP8",
"gene_metadata": {
"symbol": "NLRP8",
"name": "NLR family pyrin domain containing 8",
"family": "NLR family|Pyrin domain containing",
"ensembl_id": null
},
"cell": "LPS853",
... |
e4c0384a-6d6 | EPS8L3 | DMS53 | ACH-000698 | essential | 0 | inconclusive | poor | Lung | iid | {
"chronos": -0.238,
"p_dependency": 0.132
} | {
"symbol": "EPS8L3",
"name": "EPS8 signaling adaptor L3",
"family": "EPS8 signaling adaptor family",
"ensembl_id": null
} | {
"cell_name": "DMS53",
"model_id": "ACH-000698",
"lineage": "Lung",
"disease": "Lung Neuroendocrine Tumor",
"subtype": "Small Cell Lung Cancer",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "coessential_pathway",
"related": true,
"gene": "AMIGO1",
"gene_metadata": {
"symbol": "AMIGO1",
"name": "adhesion molecule with Ig like domain 1",
"family": "V-set domain containing",
"ensembl_id": null
},
"cell": "DMS53",
... |
b56ee39b-8c5 | DSCC1 | 95T1000 | ACH-001796 | essential | 1 | null | rich | Soft Tissue | iid | {
"chronos": -0.672,
"p_dependency": 0.826
} | {
"symbol": "DSCC1",
"name": "DNA replication and sister chromatid cohesion 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "95T1000",
"model_id": "ACH-001796",
"lineage": "Soft Tissue",
"disease": "Liposarcoma",
"subtype": "Well-Differentiated Liposarcoma",
"sex": "Male",
"primary_metastasis": null,
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "CEACAM7",
"gene_metadata": {
"symbol": "CEACAM7",
"name": "CEA cell adhesion molecule 7",
"family": "V-set domain containing|CEA cell adhesion molecule family",
"ensembl_id": null
},
"ce... |
0a554ad5-910 | PEX13 | SNU1 | ACH-000932 | essential | 0 | inconclusive | poor | Esophagus/Stomach | iid | {
"chronos": -0.223,
"p_dependency": 0.182
} | {
"symbol": "PEX13",
"name": "peroxisomal biogenesis factor 13",
"family": "Peroxins",
"ensembl_id": null
} | {
"cell_name": "SNU1",
"model_id": "ACH-000932",
"lineage": "Esophagus/Stomach",
"disease": "Esophagogastric Adenocarcinoma",
"subtype": "Stomach Adenocarcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"KRAS",
"CNOT1",
"SMAD4"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "PEX13",
"gene_metadata": {
"symbol": "PEX13",
"name": "peroxisomal biogenesis factor 13",
"family": "Peroxins",
"ensembl_id": null
},
"cell": "KYSE70",
"cell_metadata":... |
48736a84-c9f | PLEKHM1 | HCC827GR5 | ACH-000029 | essential | 1 | null | rich | Lung | iid | {
"chronos": -0.518,
"p_dependency": 0.719
} | {
"symbol": "PLEKHM1",
"name": "pleckstrin homology and RUN domain containing M1",
"family": "Pleckstrin homology domain containing",
"ensembl_id": null
} | {
"cell_name": "HCC827GR5",
"model_id": "ACH-000029",
"lineage": "Lung",
"disease": "Non-Small Cell Lung Cancer",
"subtype": "Lung Adenocarcinoma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "expression",
"context_type": "molecular_expression",
"related": true,
"gene": "PLEKHM1",
"gene_metadata": {
"symbol": "PLEKHM1",
"name": "pleckstrin homology and RUN domain containing M1",
"family": "Pleckstrin homology domain containing",
"ensembl_id": nul... |
7e0c8011-a50 | USP32 | EOL1 | ACH-000198 | essential | 1 | null | moderate | Myeloid | gene | {
"chronos": -0.512,
"p_dependency": 0.753
} | {
"symbol": "USP32",
"name": "ubiquitin specific peptidase 32",
"family": "Ubiquitin specific peptidases|EF-hand domain containing",
"ensembl_id": null
} | {
"cell_name": "EOL1",
"model_id": "ACH-000198",
"lineage": "Myeloid",
"disease": "Myeloproliferative Neoplasms",
"subtype": "Chronic Eosinophilic Leukemia, NOS",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"PIK3CB"
]
} | [
{
"modality": "copy_number",
"context_type": "molecular_cn",
"related": true,
"gene": "USP32",
"gene_metadata": {
"symbol": "USP32",
"name": "ubiquitin specific peptidase 32",
"family": "Ubiquitin specific peptidases|EF-hand domain containing",
"ensembl_id": null
},
... |
c6599392-a90 | ADRM1 | HS294T | ACH-000014 | essential | 1 | null | rich | Skin | iid | {
"chronos": -1.037,
"p_dependency": 0.985
} | {
"symbol": "ADRM1",
"name": "ADRM1 26S proteasome ubiquitin receptor",
"family": "Proteasome",
"ensembl_id": null
} | {
"cell_name": "HS294T",
"model_id": "ACH-000014",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"TERT",
"BRAF"
]
} | [
{
"modality": "crispr",
"context_type": "coessential_pathway",
"related": true,
"gene": "USP38",
"gene_metadata": {
"symbol": "USP38",
"name": "ubiquitin specific peptidase 38",
"family": "Ubiquitin specific peptidases",
"ensembl_id": null
},
"cell": "HS294T",
... |
37518c39-136 | EAF1 | MM485 | ACH-001973 | essential | 1 | null | rich | Skin | iid | {
"chronos": -0.542,
"p_dependency": 0.621
} | {
"symbol": "EAF1",
"name": "ELL associated factor 1",
"family": null,
"ensembl_id": null
} | {
"cell_name": "MM485",
"model_id": "ACH-001973",
"lineage": "Skin",
"disease": "Melanoma",
"subtype": "Melanoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"NRAS",
"TP63",
"TERT"
]
} | [
{
"modality": "mutation",
"context_type": "molecular_mutation",
"related": true,
"gene": "EAF1",
"gene_metadata": {
"symbol": "EAF1",
"name": "ELL associated factor 1",
"family": null,
"ensembl_id": null
},
"cell": "MM485",
"cell_metadata": {
"cell_name"... |
493a2cb4-555 | WNK4 | ES8 | ACH-002109 | essential | 0 | inconclusive | poor | Bone | iid | {
"chronos": -0.092,
"p_dependency": 0.045
} | {
"symbol": "WNK4",
"name": "WNK lysine deficient protein kinase 4",
"family": "WNK lysine deficient protein kinases",
"ensembl_id": null
} | {
"cell_name": "ES8",
"model_id": "ACH-002109",
"lineage": "Bone",
"disease": "Ewing Sarcoma",
"subtype": "Ewing Sarcoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "same_gene_other_lineage",
"related": true,
"gene": "WNK4",
"gene_metadata": {
"symbol": "WNK4",
"name": "WNK lysine deficient protein kinase 4",
"family": "WNK lysine deficient protein kinases",
"ensembl_id": null
},
"cell"... |
aaaf45aa-ef1 | TBL1XR1 | KOSC2 | ACH-001543 | essential | 1 | null | rich | Head and Neck | iid | {
"chronos": -1.154,
"p_dependency": 0.993
} | {
"symbol": "TBL1XR1",
"name": "TBL1X/Y related 1",
"family": "WD repeat domain containing|NCoR/SMRT transcriptional repression complex subunits",
"ensembl_id": null
} | {
"cell_name": "KOSC2",
"model_id": "ACH-001543",
"lineage": "Head and Neck",
"disease": "Head and Neck Squamous Cell Carcinoma",
"subtype": "Oral Cavity Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"ZNF570"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "DRGX",
"gene_metadata": {
"symbol": "DRGX",
"name": "dorsal root ganglia homeobox",
"family": "PRD class homeoboxes and pseudogenes",
"ensembl_id": null
},
"cell": "KOSC2",
"cell_met... |
dad3e127-a62 | TTLL11 | TE9 | ACH-000694 | essential | 0 | inconclusive | moderate | Esophagus/Stomach | gene | {
"chronos": -0.147,
"p_dependency": 0.093
} | {
"symbol": "TTLL11",
"name": "tubulin tyrosine ligase like 11",
"family": "Tubulin tyrosine ligase family",
"ensembl_id": null
} | {
"cell_name": "TE9",
"model_id": "ACH-000694",
"lineage": "Esophagus/Stomach",
"disease": "Esophageal Squamous Cell Carcinoma",
"subtype": "Esophageal Squamous Cell Carcinoma",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "FLG2",
"gene_metadata": {
"symbol": "FLG2",
"name": "filaggrin 2",
"family": "EF-hand domain containing|S100 fused type protein family",
"ensembl_id": null
},
"cell": "TE9",
"cell_me... |
f9dec845-122 | EDF1 | NB6 | ACH-002284 | essential | 0 | refuted | moderate | Peripheral Nervous System | iid | {
"chronos": 0.334,
"p_dependency": 0.001
} | {
"symbol": "EDF1",
"name": "endothelial differentiation related factor 1",
"family": "Cilia and flagella associated",
"ensembl_id": null
} | {
"cell_name": "NB6",
"model_id": "ACH-002284",
"lineage": "Peripheral Nervous System",
"disease": "Neuroblastoma",
"subtype": "Neuroblastoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": []
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "IFNK",
"gene_metadata": {
"symbol": "IFNK",
"name": "interferon kappa",
"family": "Interferons",
"ensembl_id": null
},
"cell": "NB6",
"cell_metadata": {
"cell_name": "NB6",
... |
0ddb72a4-98e | GCSH | AMO1 | ACH-000838 | essential | 1 | null | rich | Lymphoid | iid | {
"chronos": -0.67,
"p_dependency": 0.794
} | {
"symbol": "GCSH",
"name": "glycine cleavage system protein H",
"family": null,
"ensembl_id": null
} | {
"cell_name": "AMO1",
"model_id": "ACH-000838",
"lineage": "Lymphoid",
"disease": "Mature B-Cell Neoplasms",
"subtype": "Plasma Cell Myeloma",
"sex": "Female",
"primary_metastasis": "Primary",
"driver_mutations": [
"KRAS"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "GCSH",
"gene_metadata": {
"symbol": "GCSH",
"name": "glycine cleavage system protein H",
"family": null,
"ensembl_id": null
},
"cell": "SEM",
"cell_metadata": {
"... |
576cbfd5-ffe | AIP | SNU601 | ACH-000736 | essential | 0 | refuted | poor | Esophagus/Stomach | iid | {
"chronos": 0.407,
"p_dependency": 0
} | {
"symbol": "AIP",
"name": "aryl hydrocarbon receptor interacting protein",
"family": "FKBP prolyl isomerases|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "SNU601",
"model_id": "ACH-000736",
"lineage": "Esophagus/Stomach",
"disease": "Esophagogastric Adenocarcinoma",
"subtype": "Signet Ring Cell Carcinoma of the Stomach",
"sex": "Male",
"primary_metastasis": "Metastatic",
"driver_mutations": [
"KRAS",
"PIK3CA",
"CDKN2A"
]
} | [
{
"modality": "crispr",
"context_type": "control",
"related": false,
"gene": "CSN3",
"gene_metadata": {
"symbol": "CSN3",
"name": "casein kappa",
"family": "Secretory calcium-binding phosphoprotein family",
"ensembl_id": null
},
"cell": "SNU601",
"cell_metadat... |
4cf33132-062 | MED13L | MOGGUVW | ACH-001126 | essential | 0 | inconclusive | poor | CNS/Brain | iid | {
"chronos": -0.149,
"p_dependency": 0.069
} | {
"symbol": "MED13L",
"name": "mediator complex subunit 13L",
"family": "Mediator complex|MicroRNA protein coding host genes",
"ensembl_id": null
} | {
"cell_name": "MOGGUVW",
"model_id": "ACH-001126",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Anaplastic Astrocytoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"OR5D13"
]
} | [
{
"modality": "crispr",
"context_type": "same_gene_same_lineage",
"related": true,
"gene": "MED13L",
"gene_metadata": {
"symbol": "MED13L",
"name": "mediator complex subunit 13L",
"family": "Mediator complex|MicroRNA protein coding host genes",
"ensembl_id": null
},
... |
b0a26450-f98 | SLC25A28 | LN235 | ACH-000591 | essential | 1 | null | rich | CNS/Brain | gene | {
"chronos": -0.79,
"p_dependency": 0.931
} | {
"symbol": "SLC25A28",
"name": "solute carrier family 25 member 28",
"family": "Solute carrier family 25",
"ensembl_id": null
} | {
"cell_name": "LN235",
"model_id": "ACH-000591",
"lineage": "CNS/Brain",
"disease": "Diffuse Glioma",
"subtype": "Astrocytoma",
"sex": "Male",
"primary_metastasis": "Primary",
"driver_mutations": [
"TERT"
]
} | [
{
"modality": "crispr",
"context_type": "coessential_pathway",
"related": true,
"gene": "POLE4",
"gene_metadata": {
"symbol": "POLE4",
"name": "DNA polymerase epsilon 4, accessory subunit",
"family": "DNA polymerases",
"ensembl_id": null
},
"cell": "LN235",
"c... |
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