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Genetics and Pathogenesis of Feline Infectious Peritonitis Virus | Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically d... |
A hybrid approach to tracheostomy in COVID‐19 patients ensuring staff safety | |
Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases | Studies have demonstrated that ~60%–80% of emerging infectious diseases (EIDs) in humans originated from wild life. Bats are natural reservoirs of a large variety of viruses, including many important zoonotic viruses that cause severe diseases in humans and domestic animals. However, the understanding of the viral popu... |
Disseminated encephalomyelitis in children | Abstract The advent of MRI has contributed to increase the interest and awareness in childhood white matter disorders. A major priority is to distinguish transient and self-limited demyelinating syndromes like disseminated encephalomyelitis (DEM), from life-long diseases like multiple sclerosis (MS). However, the term ... |
Italy in lockdown | With the second-highest number of coronavirus cases globally, Italy is taking dramatic steps to slow the spread, reports Adam Vaughan |
A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion | BACKGROUND: Infectious respiratory diseases are transmitted to non-infected subjects when an infected person expels pathogenic microorganisms to the surrounding environment when coughing or sneezing. When the airway mucus layer interacts with high-speed airflow, droplets are expelled as aerosol; their concentration and... |
Detection of bovine coronaviruses from adult cows with epizootic diarrhea and their antigenic and biological diversities | Bovine coronavirus (BCV) was detected by reverse transcriptase-PCR, immune electron microscopy or virus isolation from adult cows at 6 out of 6 outbreaks of epizootic diarrhea in Japan. Six BCVs isolated in feces, intestinal content or tracheal exudate of the cows were analyzed for their antigenic properties by cross v... |
Nuclear Magnetic Resonance-Assisted Prediction of Secondary Structure for RNA: Incorporation of Direction-Dependent Chemical Shift Constraints | [Image: see text] Knowledge of RNA structure is necessary to determine structure–function relationships and to facilitate design of potential therapeutics. RNA secondary structure prediction can be improved by applying constraints from nuclear magnetic resonance (NMR) experiments to a dynamic programming algorithm. Imi... |
Les actualités de DDS 1er trimestre 2020 | |
Single primer isothermal amplification (SPIA) combined with next generation sequencing provides complete bovine coronavirus genome coverage and higher sequence depth compared to sequence-independent single primer amplification (SISPA) | Coronaviruses are of major importance for both animal and human health. With the emergence of novel coronaviruses such as SARS and MERS, the need for fast genome characterisation is ever so important. Further, in order to understand the influence of quasispecies of these viruses in relation to biology, techniques for d... |
Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance | Abstract Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most p... |
Pneumonie virale sévère de l'immunocompétent | Résumé Les infections virales respiratoires communautaires sont fréquentes et le plus souvent bénignes. Beaucoup d'agents différents comme les virus influenza, ou para-influenza, le virus respiratoire syncitial, les rhinovirus, coronavirus, adénovirus et les herpès virus peuvent être isolés chez les patients immunocomp... |
More than efficacy revealed by single-cell analysis of antiviral therapeutics | Development of antiviral therapeutics emphasizes minimization of the effective dose and maximization of the toxic dose, first in cell culture and later in animal models. Long-term success of an antiviral therapeutic is determined not only by its efficacy but also by the duration of time required for drug-resistance to ... |
Will you be covered during the next recession? Unequal safety-nets for private health insurance in the United States | Abstract Health insurance coverage for working-age adults in the United States is still predominantly determined by their jobs or their spouse’s jobs. This article revealed that SES disparities in access to a spouse’s coverage as a safety-net significantly contributed to the inequities in coverage loss during economic ... |
Nanopore sequencing as a revolutionary diagnostic tool for porcine viral enteric disease complexes identifies porcine kobuvirus as an important enteric virus | Enteric diseases in swine are often caused by different pathogens and thus metagenomics are a useful tool for diagnostics. The capacities of nanopore sequencing for viral diagnostics were investigated here. First, cell culture-grown porcine epidemic diarrhea virus and rotavirus A were pooled and sequenced on a MinION. ... |
The microarray revolution: Perspectives from educators | In recent years, microarray analysis has become a key experimental tool, enabling the analysis of genome‐wide patterns of gene expression. This review approaches the microarray revolution with a focus upon four topics: 1) the early development of this technology and its application to cancer diagnostics; 2) a primer of... |
Digital Orthopaedics. A Glimpse into the Future in The Midst of a Pandemic | Abstract Background The response to COVID-19 catalyzed the adoption and integration of digital health tools into the healthcare delivery model for musculoskeletal patients. The change, suspension or relaxation of Medicare and federal guidelines enabled the rapid implementation of these technologies. The expansion of pa... |
Asymptomatic Transmission, the Achilles’ Heel of Current Strategies to Control Covid-19 | |
Effectiveness of interventions targeting air travellers for delaying local outbreaks of SARS-CoV-2 | BACKGROUND: We evaluated if interventions aimed at air travellers can delay local SARS-CoV-2 community transmission in a previously unaffected country. METHODS: We simulated infected air travellers arriving into countries with no sustained SARS-CoV-2 transmission or other introduction routes from affected regions. We a... |
A comparison of infection control program resources, activities, and antibiotic resistant organism rates in Canadian acute care hospitals in 1999 and 2005: Pre- and post-severe acute respiratory syndrome | BACKGROUND: The Resources for Infection Control in Hospitals (RICH) project assessed infection control programs and rates of antibiotic-resistant organisms (AROs) in Canadian acute care hospitals in 1999. In the meantime, the severe acute respiratory syndrome (SARS) outbreak and the concern over pandemic influenza have... |
Passive protection of neonatal calves against bovine coronavirus-induced diarrhea by administration of egg yolk or colostrum antibody powder | Abstract The protective effect of egg yolk and colostrum powders prepared from hens and cows vaccinated with inactivated bovine coronavirus (BCV) antigen was evaluated in a challenge model with a virulent BCV strain. Twenty three calves from BCV-free herds were randomly divided into control and several treatment groups... |
Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication | Abstract Fulminant hepatic failure (FHF) is the severe form of hepatitis E virus infection. Virus sequence analyses from severe cases have shown presence of unique and highly conserved mutations in the helicase domain of genotype 1, 3 and 4 viruses. We evaluated role of two amino acid replacements (L1110F) and (V1120I)... |
Beneficial actions of melatonin in the management of viral infections: a new use for this “molecular handyman”? | Melatonin (N‐acetyl‐5‐methoxytryptamine) is a multifunctional signaling molecule that has a variety of important functions. Numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine. Clinical trials have shown that melatonin is efficient in preventing cell damage und... |
Performance of Pneumonia Severity Index and CURB-65 in Predicting 30-day mortality in patients with COVID-19 | Abstract Objective The aim of the study was to analyze the usefulness of the CURB-65 and pneumonia severity index (PSI) in predicting 30-day mortality in patients with COVID-19 and to identify other factors associated with higher mortality. Methods A retrospective study was performed at a pandemic hospital in Istanbul,... |
Ranking hazards pertaining to human health concerns from land application of anaerobic digestate | Abstract Anaerobic digestion (AD) has been identified as one of the cleanest producers of green energy. AD typically uses organic materials as feedstock and, through a series of biological processes, produces methane. Farmyard manure and slurry (FYM&S) are important AD feedstock and are typically mixed with agricultura... |
Poliovirus Replication Requires the N-terminus but not the Catalytic Sec7 Domain of ArfGEF GBF1 | Viruses are intracellular parasites whose reproduction relies on factors provided by the host. The cellular protein GBF1 is critical for poliovirus replication. Here we show that the contribution of GBF1 to virus replication is different from its known activities in uninfected cells. Normally GBF1 activates the Arf GTP... |
Influenza-Associated Mortality in Georgia (2009–2011) | We analyzed data from NCDCPH Georgia where samples from outpatients with influenza-like illness (ILI) and inpatients with severe acute respiratory syndrome (SARI) are referred for testing on influenza virus using PCR analysis. During 2009-2010 and 2010-2011 influenza pandemics total number of the laboratory-confirmed i... |
Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice | BACKGROUND: Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease. METHODS: In this study, we generated MARV virus-like particles (V... |
Prevalence of feline coronavirus | |
Recent advances in identifying and theorizing the role of immigrant entrepreneurs, ethnicity, and culture in industrial marketing | Abstract This special issue of Industrial Marketing Management (IMM) features four articles that cover topics related to immigrant entrepreneurs, ethnicity, and culture in industrial marketing. This introductory paper summarizes the contributions of these articles and points out future research directions. |
The Courage to Change the Rules: A Proposal for an Essential Health R&D Treaty | The medical needs of many of the world's population go unmet. A new treaty on essential health R&D could provide a binding framework to redirect today's scientific expertise to priority needs |
Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs | [Image: see text] The suggested bat origin for Middle East respiratory syndrome coronavirus (MERS-CoV) has revitalized the studies of other bat-derived coronaviruses with respect to interspecies transmission potential. Bat coronavirus (BatCoV) HKU9 is an important betacoronavirus (betaCoV) that is phylogenetically affi... |
Severe varicella-zoster virus pneumonia: a multicenter cohort study | BACKGROUND: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). METHODS: This was an ob... |
A decomposition-ensemble approach for tourism forecasting | Abstract With the frequent occurrence of irregular events in recent years, the tourism industry in some areas, such as Hong Kong, has suffered great volatility. To enhance the predictive accuracy of tourism demand forecasting, a decomposition-ensemble approach is developed based on the complete ensemble empirical mode ... |
Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study | BACKGROUND: A range of public health measures have been implemented to suppress local transmission of coronavirus disease 2019 (COVID-19) in Hong Kong. We examined the effect of these interventions and behavioural changes of the public on the incidence of COVID-19, as well as on influenza virus infections, which might ... |
Public Health Responses to and Challenges for the Control of Dengue Transmission in High-Income Countries: Four Case Studies | Dengue has a negative impact in low- and lower middle-income countries, but also affects upper middle- and high-income countries. Despite the efforts at controlling this disease, it is unclear why dengue remains an issue in affluent countries. A better understanding of dengue epidemiology and its burden, and those of c... |
Neisseria meningitidis pneumonia with bacteremia without meningitis: an atypical presentation | Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide. The second most common and potentially severe end-organ manifestation of invasive meningococcal disease is meningococcal pneumonia. It occurs between 5% and 15% of all patients with invasive meningococcal disease. N. meningitidis... |
Recent insights for the emerging COVID-19: drug discovery, therapeutic options and vaccine development | SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population, causing over 5.5 million confirmed cases worldwide. As COVID-19 has posed a global threat with significant human casualties and severe economic losses, there is a pressing demand to further understand the curren... |
SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in ‘lasso’ for the multi-faced virus | During the current COVID-19 pandemic, the global ratio between the dead and the survivors is approximately 1 to 10, which has put humanity on high alert and provided strong motivation for the intensive search for vaccines and drugs. It is already clear that if we follow the most likely scenario, which is similar to tha... |
„Emerging Infectious Diseases“: Dengue-Fieber, West-Nil-Fieber, SARS, Vogelgrippe, HIV | Some emerging infectious diseases have recently become endemic in Germany. Others remain confined to specific regions in the world. Physicians notice them only when travelers after infection in endemic areas present themselves with symptoms. Several of these emerging infections will be explained. HIV is an example for ... |
Chapter 7 Coronaviridae: 100,000 Years of Emergence and Reemergence | Abstract The coronavirus family (Coronaviridae) is a positive-sense single-stranded RNA, with a size of 27kb. These viruses have a potential species specificity and interspecies transmission. The interspecies transmission of viruses from one host species to another is a major factor responsible for the majority of emer... |
How Should U.S. Hospitals Prepare for Coronavirus Disease 2019 (COVID-19)? | Estimates suggest that COVID-19 will stress bed capacity, equipment, and health care personnel in U.S. hospitals in ways not previously experienced. How can health systems prepare to care for a large influx of patients with this disease? |
Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants | Respiratory infections in infancy may protect against developing Th2‐mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in ... |
The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies | SARS-CoV-2 is characterized by a spike protein allowing viral binding to the angiotensin-converting enzyme (ACE)-2, which acts as a viral receptor and is expressed on the surface of several pulmonary and extra-pulmonary cell types, including cardiac, renal, intestinal and endothelial cells. There is evidence that also ... |
Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection? | In late December 2019, a novel coronavirus (SARS-CoV-2 or CoV-19) appeared in Wuhan, China, causing a global pandemic. SARS-CoV-2 causes mild to severe respiratory tract inflammation, often developing into lung fibrosis with thrombosis in pulmonary small vessels and causing even death. COronaVIrus Disease (COVID-19) pa... |
A convenient colorimetric assay for the quantification of porcine epidemic diarrhea virus and neutralizing antibodies | Abstract Neonatal enteritis caused by the porcine epidemic diarrhea virus (PEDV) is an important cause of high mortality and economic losses to the swine industry. Virus neutralization (V/N) assays are commonly requested in diagnostic laboratories for the assessment of protective antibodies. However, the visual assessm... |
An Invited Commentary on: Emergency and Essential Surgical Healthcare Services during COVID-19 in Low- And Middle-Income Countries: a Perspective | |
Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 | In Réunion Island, despite an influenza surveillance established since 1996 by the sentinel general practitioner’s network, little is known about the etiology of Influenza like-illness (ILI) that differs from influenza viruses in a tropical area. We set up a retrospective study using nasal swabs collected by sentinel G... |
Management and outcomes of a Vascular Surgery Department with sudden medical staff outbreak of COVID-19 | |
Chapter 34 The Experimental Use of Syrian Hamsters | The Syrian hamster (Mesocricetus auratus) possesses a variety of unique features which make them desirable research models. Despite these features, experimental use of the hamster has declined over the past 20–30 years. The current chapter will focus on research and literature describing the experimental use of the ham... |
Vascularites associées aux infections virales | Résumé Des virus, causes de vascularites Si la plupart des vascularites systémiques sont de cause inconnue, la responsabilité d’une infection virale a été démontrée de façon formelle pour certaines d’entre elles, un traitement spécifique pouvant les guérir définitivement. Chaque virus incriminé rend compte d’un type pa... |
Influenza virus RNA recovered from droplets and droplet nuclei emitted by adults in an acute care setting | Transmission in hospital settings of seasonal influenza viruses and novel agents such as the Middle East respiratory syndrome coronavirus (MERS-CoV) is well-described but poorly understood. The characterization of potentially infectious bio-aerosols in the healthcare setting remains an important yet ill-defined factor ... |
Evaluation of the Cadi ThermoSENSOR Wireless Skin-Contact Thermometer Against Ear and Axillary Temperatures in Children | The Cadi ThermoSENSOR skin-contact thermometer measures body temperature continuously and transmits readings wirelessly to a central server. This study evaluated the ThermoSENSOR against ear temperatures (ETs) measured by a Braun ThermoScan ear thermometer and axillary temperatures (ATs) measured by a Terumo digital cl... |
Une enquête sur le rôle joué par les pharmaciens d’officine durant la crise sanitaire | |
Public Perceptions of Hospital Responsibilities to Those Presenting Without Medical Injury or Illness During a Disaster | Abstract Background During natural and manmade disasters, the hospital is perceived as a central rallying and care site for the public, for both those with and without emergency medical needs. The expectations of the public may outstrip hospital plans and abilities to provide nonmedical assistance. Objective Our object... |
Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen | Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection ... |
Intersection of Gene Therapy and Progenitor Cell Biology in the Lung | |
Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes | OBJECTIVES: Coronavirus disease 2019 (COVID-19) most commonly presents with respiratory symptoms, including cough, shortness of breath, and sore throat. However, digestive symptoms also occur in patients with COVID-19 and are often described in outpatients with less severe disease. In this study, we sought to describe ... |
SARS virus claims its third victim in Canada | |
Coronavirus infection of polarized epithelial cells | Abstract Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directio... |
Helping Couples in the Shadow of COVID‐19 | The pandemic caused by the SARS‐CoV‐2 virus (coronavirus) and the associated illness, COVID‐19, has caused a level of worldwide upheaval unlike any most people now living have seen in their lifetimes. This crisis affects people in their most important, committed, and intimate relationships. Although this crisis has dam... |
Report from the World Health Organization's Product Development for Vaccines Advisory Committee (PDVAC) meeting, Geneva, 7–9th Sep 2015 | Abstract There are more vaccines in development, against a greater number of pathogens, than ever before. A challenge with this exceptional level of activity and investment is how to select and resource the most promising approaches to have the most significant impact on public health. The WHO Product Development for V... |
Establishment of a Porcine Parvovirus (PPV) LAMP Visual Rapid Detection Method | Porcine parvovirus (PPV) is one of the major causes of reproductive pig disease. Due to its serious nature, wide spread and consequent great damage to the swine industry, an effective, rapid and convenient method for its detection is needed. A loop-mediated isothermal amplification (LAMP) assay was established to detec... |
Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices | Canine acute diarrhoea is frequently observed in first opinion practice, though little is known about commonly used diagnostic or therapeutic management plans, including use of antimicrobials. This retrospective observational study utilised electronic health records augmented with practitioner-completed questionnaires ... |
Predictors of viral pneumonia: The need for viral testing in all patients hospitalized for nursing home‐acquired pneumonia | AIM: Community‐acquired pneumonia (CAP) is presumed to be bacterial in origin and empirical antibiotics are almost always given on admission. However, early detection of viral infection is also very important for hospital infection control and timely use of antiviral agents. The present study aimed to compare patients ... |
Higher-Order Analysis of Probabilistic Long-Term Loss under Nonstationary Hazards | Abstract Quantification of hazard-induced losses plays a significant role in risk assessment and management of civil infrastructure subjected to hazards in a life-cycle context. A rational approach to assess long-term loss is of vital importance. The loss assessment associated with stationary hazard models and low-orde... |
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus | BACKGROUND: Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in ferrets ... |
Novel and established intestinal cell line models – An indispensable tool in food science and nutrition | This review presents the applications of intestinal cell models of human and pig origin in food and nutritional sciences and highlights their potential as in vitro platforms for preclinical research. Intestinal cell models are used in studies of bioavailability, adsorption and transport in nutritional or toxicological ... |
A Simulation Study Comparing Epidemic Dynamics on Exponential Random Graph and Edge-Triangle Configuration Type Contact Network Models | We compare two broad types of empirically grounded random network models in terms of their abilities to capture both network features and simulated Susceptible-Infected-Recovered (SIR) epidemic dynamics. The types of network models are exponential random graph models (ERGMs) and extensions of the configuration model. W... |
Suicide and Lyme and associated diseases | PURPOSE: The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject. INTRODUCTION: Multiple case reports and other references demonstrate a causal association between suicidal risk... |
Nonspecific inhibitors of coronavirus OC43 haemagglutination in human sera | Antibodies against the human coronavirus OC43 in human sera were measured by haemagglutination inhibition (HI), complement fixation (CF), and radial diffusion-haemolysis in gel (HIG) techniques. The apparent HI titres in a fraction of sera with no antibodies detectable by the two other methods were found to be reduced ... |
Testing for multiple bubbles in the copper price: Periodically collapsing behavior | Abstract This study investigates whether multiple bubbles exist in the copper price on the basis of the Generalized Supremum Augmented Dickey-Fuller (GSADF) approach (Phillips et al., 2013). This technique delivers date-stamping strategies for the emergence as well as collapse of explosive bubble episodes and is best s... |
ID: 101 Investigating the role of interferon λ4 in hepatitis C virus infection | IFNL4, a recently discovered member of the interferon λ family (IFNλs or type III IFNs), is a pseudogene in a significant fraction of the human population. A single nucleotide polymorphism located in IFNL4, which determines the ability to express IFNλ4, has been correlated with poor spontaneous and treatment-induced cl... |
French Intensive Care Society, International congress – Réanimation 2016 | PHYSICIANS ABSTRACTS O1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized controlled study (BEST CUFF) Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Fr... |
Original Article: Real time reverse transcription (RRT)‐polymerase chain reaction (PCR) methods for detection of pandemic (H1N1) 2009 influenza virus and European swine influenza A virus infections in pigs | Please cite this paper as: Slomka et al. (2010) Real time reverse transcription (RRT)‐polymerase chain reaction (PCR) methods for detection of pandemic (H1N1) 2009 influenza virus and European swine influenza A virus infections in pigs. Influenza and Other Respiratory Viruses 4(5), 277–293. Background There is a requir... |
Massive cutback in orthopaedic healthcare services due to the COVID-19 pandemic | PURPOSE: Due to the lack of evidence, it was the aim of the study to investigate current possible cutbacks in orthopaedic healthcare due to the coronavirus disease 2019 pandemic (COVID-19). METHODS: An online survey was performed of orthopaedic surgeons in the German-speaking Arthroscopy Society (Gesellschaft für Arthr... |
Camfil starts making CamProtect face masks in Sweden | Responding to the coronavirus pandemic, Camfil is manufacturing respiratory protection masks in Sweden that have been designed and developed at its laboratory in Trosa Tech Center. |
Management of Telogen Effluvium During The Covid‐19 Emergency: Psychological Implications | |
Detection of Recently Discovered Human Polyomaviruses in a Longitudinal Kidney Transplant Cohort | A large number of human polyomaviruses have been discovered in the last 7 years. However, little is known about the clinical impact on vulnerable immunosuppressed patient populations. Blood, urine, and respiratory swabs collected from a prospective, longitudinal adult kidney transplant cohort (n = 167) generally pre‐op... |
Meta-transcriptomics and the evolutionary biology of RNA viruses | Abstract Metagenomics is transforming the study of virus evolution, allowing the full assemblage of virus genomes within a host sample to be determined rapidly and cheaply. The genomic analysis of complete transcriptomes, so-called meta-transcriptomics, is providing a particularly rich source of data on the global dive... |
Synthesis, Spectroscopic Characterizations of Novel Norcantharimides, Their ADME Properties and Docking Studies Against COVID‐19 M(pr)° | A series of novel Norcantharimide derivatives were synthesized and their structures were characterized by FTIR, (1)H and (13)C NMR spectroscopy as well as elemental analyses. The absorption, distribution, metabolism and excretion (ADME) properties of the synthesized molecules were investigated. The results obtained in ... |
Solving one of the pieces of the puzzle: COVID-19 and type 2 diabetes() | The emergence of the COVID-19 pandemic represents an enormous challenge. Given the considerable presence of type 2 diabetes mellitus in the current population, the pandemic is a health issue that requires an effort to provide better responses to our patients who are more vulnerable to the onset of infection and who are... |
Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease‐2019 (COVID‐19) | COVID‐19 is a respiratory disease caused by a novel coronavirus and is currently a global pandemic. HLA variation is associated with COVID‐19 because HLA plays a pivotal role in the immune response to pathogens. Here, 82 individuals with COVID‐19 were genotyped for HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3/4/5, ‐DQA1, ‐DQB1, ‐DPA1, ... |
In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV | ORF 3a of human severe acute respiratory syndrome corona virus (SARS-CoV) has been identified as a 274 amino acid membrane protein. When expressed in Xenopus oocytes the protein forms channels. Based on bioinformatics approaches the topology has been identified to include three transmembrane domains (TMDs). Since struc... |
Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages | Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic acid from cis-aconitic ... |
Coronaviren als Ursache respiratorischer Infektionen | BACKGROUND: There are six human pathogenic coronaviruses (CoV), which mainly cause infections of the respiratory system. In everyday clinical practice, it is helpful to know the relevance and characteristics of these pathogens. OBJECTIVE: To present the epidemiology, clinical picture and differences of human pathogenic... |
Institution of a Novel Process for N95 Respirator Disinfection with Vaporized Hydrogen Peroxide in the setting of the COVID-19 Pandemic at a Large Academic Medical Center | Abstract Personal protective equipment (PPE) has been an invaluable yet limited resource when it comes to protecting healthcare workers against infection during the COVID-19 pandemic. In the US, N95 respirator supply chains are severely strained and conservation strategies are needed. A multidisciplinary team at the Wa... |
Oncology care in a lower middle‐income country during the COVID‐19 pandemic | |
Receptor Usage and the Pathogenesis in Acute and Chronic Virus Infections | |
MicroRNA transcriptome analysis of porcine vital organ responses to immunosuppressive porcine cytomegalovirus infection | BACKGROUND: Porcine cytomegalovirus (PCMV) is an immunosuppressive virus that mainly inhibits T-lymphocyte and macrophage immune functions; it has significantly damaged the farming industry. Although recent studies have shown that miRNAs play important roles in immune responses, the regulatory mechanisms of miRNAs duri... |
Collaboration between infection control and occupational health in three continents: a success story with international impact | Globalization has been accompanied by the rapid spread of infectious diseases, and further strain on working conditions for health workers globally. Post-SARS, Canadian occupational health and infection control researchers got together to study how to better protect health workers, and found that training was indeed pe... |
Laboratory Detection of Respiratory Viruses by Automated Techniques | Advances in clinical virology for detecting respiratory viruses have been focused on nucleic acids amplification techniques, which have converted in the reference method for the diagnosis of acute respiratory infections of viral aetiology. Improvements of current commercial molecular assays to reduce hands-on-time rely... |
SEVERE HUMAN RHINOVIRUS OUTBREAK ASSOCIATED WITH FATALITIES IN A LONG‐TERM CARE FACILITY IN ONTARIO, CANADA | |
Animal movements and the spread of infectious diseases | Domestic and wild animal population movements are important in the spread of disease. There are many recent examples of disease spread that have occurred as a result of intentional movements of livestock or wildlife. Understanding the volume of these movements and the risks associated with them is fundamental in elucid... |
Preconditioning with high mobility group box 1 protein protects against myocardial ischemia–reperfusion injury | Abstract Objective To investigate whether preconditioning with high mobility group box 1 protein (HMGB1) could reduce myocardial ischemia–reperfusion (I/R) injury. Methods and results Infarct size, lactate dehydrogenase (LDH), creatine kinase (CK), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were assessed.... |
Education and the COVID-19 pandemic | The COVID-19 pandemic is a huge challenge to education systems. This Viewpoint offers guidance to teachers, institutional heads, and officials on addressing the crisis. What preparations should institutions make in the short time available and how do they address students’ needs by level and field of study? Reassuring ... |
Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases | The dynamics of infectious disease epidemics are driven by interactions between individuals with differing disease status (e.g., susceptible, infected, immune). Mechanistic models that capture the dynamics of such “dependent happenings” are a fundamental tool of infectious disease epidemiology. Recent methodological ad... |
SARS-CoV-2 et Cancer en France: les internes d’oncologie en première ligne. Témoignage des internes d’oncologie de deux clusters français, le Grand Est et l’Île de France | Résumé Un nouveau coronavirus, le SARS-CoV-2 est responsable de la première pandémie du XXIe siècle. Après la région de Wuhan, Hubei en Chine, premier cluster de ce virus, les pays européens, dont la France, sont actuellement les pays avec le plus de nouveaux cas de patients contaminés. Cette épidémie bouleverse l’orga... |
Artificial Intelligence during a pandemic: The COVID‐19 example | |
Very low reporting rate of connective tissue diseases among coronavirus disease 2019 (Covid-19) patients and the renin-angiotensin system – an overlooked association? |
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