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A Structured Tool for Communication and Care Planning in the Era of the COVID-19 Pandemic | Abstract Residents in long-term care settings are particularly vulnerable to COVID-19 infections and, compared to younger adults, are at higher risk of poor outcomes and death. Given the poor prognosis of resuscitation outcomes for COVID-19 in general, the specter of COVID-19 in long-term care residents should prompt r... |
Human papillomavirus type 16 E6-specific antitumor immunity is induced by oral administration of HPV16 E6-expressing Lactobacillus casei in C57BL/6 mice | Given that local cell-mediated immunity (CMI) against the human papillomavirus type 16 E6 (HPV16 E6) protein is important for eradication of HPV16 E6-expressing cancer cells in the cervical mucosa, the HPV16 E6 protein may be a target for the mucosal immunotherapy of cervical cancer. Here, we expressed the HPV16 E6 ant... |
Covid-19: Japan’s success despite inept bureaucracy and incompetence | |
Chapter 3 Preemptive and Proactive Strategies for Food Control and Biosecurity | Abstract Food security, sustainable agriculture, and healthy nutrition are the keystones of sustainable development of society that foster the long-lasting well-being of the human population. The global occurrence of exotic diseases, emerging and remerging pathogens, biological weapons, urbanization, and population exp... |
Herpes zoster and severe acute herpetic neuralgia as a complication of COVID-19 infection | |
Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies | Lyssaviruses are bullet-shaped, single-stranded, negative-sense RNA viruses and the causative agents of the ancient zoonosis rabies. Africa is the likely home to the ancestors of taxa residing within the Genus Lyssavirus, Family Rhabdoviridae. Diverse lyssaviruses are envisioned as co-evolving with bats, as the ultimat... |
Monoclonal Antibodies and Antibody Like Fragments Derived from Immunised Phage Display Libraries | Morbidity and mortality associated with infectious diseases are always on the rise, especially in poorer countries and in the aging population. The inevitable, but unpredictable emergence of new infectious diseases has become a global threat. HIV/AIDS, severe acute respiratory syndrome (SARS), and the more recent H1N1 ... |
COVID-19: Obstetric anesthesia care considerations | • Pre-hospital COVID-19 screening should be implemented for all pregnant patients. • Limit the number of staff in a delivery room or operating room when feasible; • Encourage the use of video messaging with other members of the patient's support system; • An experienced provider should perform neuraxial procedures and ... |
Lupus anticoagulant is frequent in patients with Covid‐19 | Patients hospitalized for Covid-19 severe infection are more prone to excessive coagulation activation leading to thrombotic events. Tang et al.1 discussed the importance of high D-dimer and Fibrin degradation product level to determine the patient prognostic and the risk of thrombosis. However they did not look at lup... |
Pre- e post-operative screening in limited-term elective oncological surgery patients during the COVID-19 pandemic period | |
IL‐17A contributes to HSV1 infection‐induced acute lung injury in a mouse model of pulmonary fibrosis | BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) often experience acute exacerbation (AE) after an episode of common cold. AIMS: To establish a mouse model of virus infection‐induced AE‐IPF and investigate the mechanism underlying the AE‐IPF. METHODS: Herpes simplex virus 1 (HSV1) was inoculated intranasal... |
Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units | Abstract Background Timely diagnostic investigation to establish the microbial etiology of pneumonia is essential to ensure the administration of effective antibiotic therapy to individual patients. Methods We evaluated a multiplex PCR assay panel, the FilmArray® pneumonia panel (FilmArray PP, BioFire Diagnostics), for... |
Ionic liquid based ultrasonic assisted extraction of isoflavones from Iris tectorum Maxim and subsequently separation and purification by high-speed counter-current chromatography | Abstract We developed an ionic liquid based ultrasonic assisted extraction (ILUAE) method for the extraction of the three isoflavones, namely tectoridin, iristectorin B and iristectorin A from Iris tectorum Maxim of the Iridaceae family. Three kinds of 1-alkyl-3-methylimidazolium ionic liquids with different alkyl chai... |
Molecular mechanisms regulating CD13-mediated adhesion | CD13/Aminopeptidase N is a transmembrane metalloproteinase that is expressed in many tissues where it regulates various cellular functions. In inflammation, CD13 is expressed on myeloid cells, is up-regulated on endothelial cells at sites of inflammation and mediates monocyte/endothelial adhesion by homotypic interacti... |
Quasispecies composition and phylogenetic analysis of feline coronaviruses (FCoVs) in naturally infected cats | Quasispecies composition and tissue distribution of feline coronaviruses (FCoVs) were studied in naturally infected cats. The genomic complexity of FCoVs was investigated using single-strand conformational polymorphism (SSCP) analysis of N and ORF7b amplicons, and the evolutionary process was investigated by sequence-b... |
Performing an urgent neonatal cardiac intervention safely during the COVID-19 pandemic | Abstract The current pandemic has driven the medical community to adapt quickly to unprecedented challenges. Among these challenges is the need to minimize staff exposure to COVID-19 during neonatal cardiac procedures. In this report, we describe measures we have taken to protect health care workers while ensuring succ... |
Overview of Telemedicine and Sleep Disorders | Telemedicine is about more than simply using audio-visual technology to care for patients, but rather an opportunity to fundamentally improve patient access, quality, efficiencies, and experience. Regarding sleep medicine, it has the potential to drive sleep medicine’s evolution. By enabling care across geographies and... |
Systems biology of virus entry in mammalian cells | In this article, we define systems biology of virus entry in mammalian cells as the discipline that combines several approaches to comprehensively understand the collective physical behaviour of virus entry routes, and to understand the coordinated operation of the functional modules and molecular machineries that lead... |
Differentiation of acid-ph-dependent and -nondependent entry pathways for mouse hepatitis virus | Abstract Early events of infection of MHV were studied in comparison with those of VSV, which is known to enter cells by an endocytic pathway. Treatment of mouse L-2 fibroblasts with ammonium chloride, chloroquine, or dansylcadaverine inhibited infection of MHV to a much lesser degree than that of VSV, suggesting a rel... |
La semFYC y la Medicina de Familia en tiempos del Coronavirus | |
Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us | The authors of this commentary call for sex- and gender-specific and differentiating factors to be urgently included in the research, prevention, and therapeutics implementation response to the coronavirus disease 2019 pandemic. |
Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection | BACKGROUND: Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative targets for the development of antivirals that inhibit their activity. Host proteases have been described... |
Do we need an ethical framework for hospital infection control? | Summary Strategies for the control of the spread of infection in hospitals may lead to constraints on individual autonomy, freedom of movement, or contact with others. Codes of (ethical) practice for healthcare professionals tend to emphasise responsibilities to individual patients. Ethical frameworks for public health... |
Structural analysis of herpes simplex virus by optical super-resolution imaging | Herpes simplex virus type-1 (HSV-1) is one of the most widespread pathogens among humans. Although the structure of HSV-1 has been extensively investigated, the precise organization of tegument and envelope proteins remains elusive. Here we use super-resolution imaging by direct stochastic optical reconstruction micros... |
Novel highly divergent reassortant bat rotaviruses in Cameroon, without evidence of zoonosis | Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenomi... |
Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017 | Porcine epidemic diarrhoea virus (PEDV) is a globally emerging and re‐emerging enteric coronavirus in pigs causing serious economic threats to the world swine industry. Since the re‐emergence of massive PEDV outbreaks in South Korea in 2013−2014, domestic pig farms have continued to experience PED epidemics or endemics... |
Tachycardie atriale chaotique au cours d’une infection respiratoire à coronavirus NL63 | Résumé Nous rapportons le cas d’un nourrisson de 3 mois hospitalisé pour une bronchiolite. Les troubles respiratoires s’étaient aggravés en 48heures et compliqués d’un état de choc. L’association d’une tachycardie, d’une cardiomégalie et d’une acidose à prédominance métabolique évoquait en premier lieu un choc cardiogé... |
“Watch Out! Pneumonia Secondary to Achromobacter Denitrificans” | Pneumonia is the cause of significant morbidity and mortality especially in developing countries. The frequency and importance of emerging new pathogens have significant implications for therapy. We report a case of pneumonia caused by a very rare organism, Achromobacter denitrificans which was treated successfully wit... |
The dynamic effects of infectious disease outbreaks: The case of pandemic influenza and human coronavirus | Pandemic influenza is a regularly recurring form of infectious disease; this work analyses its economic effects. Like many other infectious diseases influenza pandemics are usually of short, sharp duration. Human coronavirus is a less regularly recurring infectious disease. The human coronavirus pandemic of 2019 (COVID... |
The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages | We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal... |
Chapter 6 Natural Products as Cathepsin Inhibitors | Abstract Cathepsins are proteases found in all animals as well as other organisms. There are approximately a dozen members of this family, which are distinguished by their structure, their catalytic mechanism, and which proteins they cleave. Most of the members become activated at the low pH found in lysosomes. Catheps... |
Haematological Cancers and the risk of severe COVID‐19: Exploration and critical evaluation of the evidence to date | From the outset of the COVID‐19 pandemic, patients and health care professionals have been concerned that a history of haematological malignancy will lead to an increased risk of severe COVID‐19. This led to the UK government advising patients with blood cancers to shield, massive re‐organisation of NHS haematology and... |
INSUFICIENCIA RESPIRATORIA COVID-19: SOPORTE CON ECMO PARA NIÑOS Y ADULTOS JÓVENES | |
Low Utility of Repeat Real-Time PCR Testing for SARS-CoV-2 in Clinical Specimens | Abstract: In a multicenter cohort of 22,315 patients tested for COVID-19, 1676 (7.5%) had repeat testing via real-time PCR following an initial negative test. Of those retested within seven days of their first negative test, only 2.0% had a positive result. This suggests that repeat testing from the same source is unli... |
Artificial intelligence approach fighting COVID-19 with repurposing drugs | BACKGROUND: The ongoing COVID-19 pandemic has caused more than 193,825 deaths during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic medicine that has prior use experiences in patients in order to resolve the current pandemic situation before it could become worsening. Artificia... |
Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1- and 5′ppp- mRNAs | Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA’s 5′-terminal ‘cap’. The minimal ‘cap0’ consists of N7-methylguanosine linked to the first nucleotide via a 5′-5′ triphosphate (ppp) bridge. Cap0 is further modified by 2′-O-methylation of the next two riboses, yielding ‘cap1’ (m7GpppNmN) a... |
A real-time convective PCR machine in a capillary tube instrumented with a CCD-based fluorometer | Abstract This research reports the design, analysis, integration, and test of a prototype of a real-time convective polymerase chain reaction (RT-cPCR) machine that uses a color charged coupled device (CCD) for detecting the emission of fluorescence intensity from an RT-cPCR mix in a microliter volume glass capillary. ... |
Oseltamivir-Resistant Influenza Viruses A (H1N1) during 2007–2009 Influenza Seasons, Japan | To monitor oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y in neuraminidase (NA) in Japan during 2 influenza seasons, we analyzed 3,216 clinical samples by NA sequencing and/or NA inhibition assay. The total frequency of ORVs was 2.6% (45/1,734) during the 2007–08 season and 99.7% (1,477/1,482) durin... |
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells | In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and the use of the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), with severe acute respiratory syndrome coronavirus (SARS-CoV). Seve... |
Lineages, Sub-Lineages and Variants of Enterovirus 68 in Recent Outbreaks | Enterovirus 68 (EV68) was first isolated in 1962. Very few cases of EV68 infection were described over the ensuing 40 years. However, in the past few years, an increase in severe respiratory tract infections associated with EV68 has been reported. We identified two clusters of EV68 infection in South London, UK, one ea... |
Chapter 4 Gene–Environment Interactions Eco-Genetics and Toxicogenomics | Gene–environment interactions likely account for a large portion of the “missing heritability” or “dark matter” of genetic associations with traits and diseases. In concert with the powerful methods and scale of genomic population analyses, a complementary effort is needed to capture data about behavioral and environme... |
Adaptation of the ‘Assembly Line’ and ‘Brick System’ techniques for hospital resource management of personal protective equipment, as preparedness for mitigating the impact of the COVID-19 pandemic in a large public hospital in India | |
Workshop on “The Role of Indoor Air as a Vehicle for Human Pathogens”: A Panel Discussion | |
Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs | Porcine epidemic diarrhea virus (PEDV) was identified in the United States (U.S.) swine population for the first time in April 2013 and rapidly spread nationwide. However, no information has been published regarding the minimum infectious dose (MID) of PEDV in different pig models. The main objective of this study was ... |
Complete genome sequence analysis of canine bocavirus 1 identified for the first time in domestic cats | In this study, we investigated the presence of canine bocaviruses (CBoVs) in fecal samples from 105 cats with diarrhea and 92 asymptomatic cats in northeast China. One fecal sample, 17CC0312, collected from an asymptomatic cat, was found to be positive for canine bocavirus 1 (CBoV1). The nearly complete genome of this ... |
Effet bénéfique de l’association Hydroxychloroquine-Azithromycine dans le traitement des patients âgés atteints de la covid-19: résultats d’une étude observationnelle | Summary Sixty-eight patients, all over 65 years of age and diagnosed PCR-positive for covid-19, received the hydroxychloroquine / azithromycin combination between March 27 and May 1, 2020.Dosages of hydroxychloroquine and azithromycin were in accordance with the protocol of the Institut Hospitalo-Universitaire de Marse... |
COVID-19 Outbreak in North Italy: An Overview on Dentistry. A Questionnaire Survey | This survey assessed the symptoms/signs, protective measures, awareness, and perception levels regarding COVID-19 among dentists in Lombardy, Italy. Moreover, an analysis of the answers gathered in areas with different prevalence of the disease was carried out. All Lombardy’s dentists were sent an online ad hoc questio... |
n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils | Neutrophils, immune cells crucial for protecting against invading pathogens, are important in sepsis. Neutrophil migration is regulated by chemokine receptors and their cognate ligands. Our previous study investigated the effect of n-butanol extract from Folium isatidis on lipopolysaccharide (LPS)-induced septic shock.... |
The use of digital technologies by small and medium enterprises during COVID-19: Implications for theory and practice | Scholars have highlighted the role of Digital Technologies (DT) in enhancing productivity and performance in Small and Medium Enterprises (SMEs). However, there is limited evidence on the use of DT for dealing with the consequences of extreme events, such as COVID-19. We discuss this gap by (i) outlining potential rese... |
The evolution of pharmacists' roles in disasters, from logistics to assessing and prescribing. | |
Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis | Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind terminal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways th... |
Controversy over antibacterial silver: implications for environmental and sustainability assessments | Abstract The potential risks and benefits of using silver, especially nanosilver, as an antibacterial agent in consumer and healthcare products are under debate globally. Using content analysis of texts from newspaper and TV, government agencies, municipalities, government and parliament, non-governmental organizations... |
Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage | Abstract In the central nervous system (CNS), innate immune surveillance is mainly coordinated by microglia. These CNS resident myeloid cells are assumed to help orchestrate the immune response against infections of the brain. However, their specific role in this process and their interactions with CNS infiltrating imm... |
Internet Search Limitations and Pandemic Influenza, Singapore | |
Pushing the Bacterial Envelope: Strategies for Re-Engineering Bacterial Surfaces with Heterologous Proteins and Sugars | Over the past three decades, a powerful array of techniques has been developed for expressing heterologous proteins and saccharides on the surface of bacteria. Surface-engineered bacteria, in turn, have proven useful in a variety of settings, including high-throughput screening, biofuel production, and vaccinology. In ... |
A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic | Since December 2019, the global pandemic caused by the highly infectious novel coronavirus 2019-nCoV (COVID-19) has been rapidly spreading. As of April 2020, the outbreak has spread to over 210 countries, with over 2,400,000 confirmed cases and over 170,000 deaths [1]. COVID-19 causes a severe pneumonia characterized b... |
Disease Prevention: An Opportunity to Expand Edible Plant-Based Vaccines? | The lethality of infectious diseases has decreased due to the implementation of crucial sanitary procedures such as vaccination. However, the resurgence of pathogenic diseases in different parts of the world has revealed the importance of identifying novel, rapid, and concrete solutions for control and prevention. Edib... |
Editorial: New Advances in RNA Targeting | |
Contributions of international cooperation projects to the HIV/AIDS response in China | Background For 20 years, China has participated in 267 international cooperation projects against the HIV/AIDS epidemic and received ∼526 million USD from over 40 international organizations. These projects have played an important role by complementing national efforts in the fight against HIV/AIDS in China. Methods T... |
Cryo X-ray nano-tomography of vaccinia virus infected cells | Abstract We have performed full-field cryo X-ray microscopy in the water window photon energy range on vaccinia virus (VACV) infected cells to produce tomographic reconstructions. PtK2 cells were infected with a GFP-expressing VACV strain and frozen by plunge fast freezing. The infected cells were selected by light flu... |
Transfusion Risks and Transfusion-related Pro-inflammatory Responses | Despite improvements in blood screening and administration techniques, serious adverse events related to transfusion continue to occur, albeit at a much lower incidence. In addition to the development and implementation of new screening and blood purification/modification techniques and implementation of an optimal blo... |
Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial | OBJECTIVES: Primary Objective • To test the efficacy of Hydroxychloroquine (HCQ) (400 mg orally daily for 3 days then 200 mg orally daily for an additional 11 days, to complete 14 days) to prevent incident SARS-CoV-2 infection, compared to ascorbic acid among contacts of persons with SARS-CoV-2 infection Secondary obje... |
Diverse microbial interactions with the basement membrane barrier | During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50–100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion. Such passage allows pathogens to ... |
Bringing them together: Plasmid pMV158 rolling circle replication and conjugation under an evolutionary perspective | Rolling circle-replicating plasmids constitute a vast family that is particularly abundant in, but not exclusive of, Gram-positive bacteria. These plasmids are constructed as cassettes that harbor genes involved in replication and its control, mobilization, resistance determinants and one or two origins of lagging stra... |
Advances in prevention and therapy of neonatal dairy calf diarrhoea: a systematical review with emphasis on colostrum management and fluid therapy | Neonatal calf diarrhoea remains the most common cause of morbidity and mortality in preweaned dairy calves worldwide. This complex disease can be triggered by both infectious and non-infectious causes. The four most important enteropathogens leading to neonatal dairy calf diarrhoea are Escherichia coli, rota- and coron... |
SARS‐unique fold in the Rousettus bat coronavirus HKU9 | The coronavirus nonstructural protein 3 (nsp3) is a multifunctional protein that comprises multiple structural domains. This protein assists viral polyprotein cleavage, host immune interference, and may play other roles in genome replication or transcription. Here, we report the solution NMR structure of a protein from... |
CPR News | The International Institute for Conflict Prevention and Resolution in March launched a resource page on its website for conflict resolution in commercial matters when the coronavirus pandemic requires closings and social distancing. |
Posttraumatic Stress Disorder in Primary Care: A Study of General Practices in England | Posttraumatic Stress Disorder (PTSD) may be a common issue in primary care in the UK, but there have been no studies of all-cause PTSD in general samples of attenders in this country. The current paper thus explores the extent and distribution of probable PTSD among patients attending general practices in England. Cros... |
Redeploying plant defences | Epidemic diseases are not a new phenomenon, but easy access to transport in the modern world has accelerated their spread. Perhaps some botanical understanding can help slow them down. |
“Global Health”: Time to Refocus while We still Have Time | Two decades of growing resource availability from agencies and foundations in wealthy countries has transformed approaches to health in poorly resourced nations. This progress looks increasingly unstable as climate change, social unrest, and, now, disruptive pandemics present threats not only to health but also to the ... |
Inquiries to consumer lines manageable, but blitz from COVID‐19 may be coming | Operators of the many sources of telephone‐based mental health crisis support across the nation wonder whether a fairly busy March of fielding concerns about the novel coronavirus could transition to an unmanageable April. |
A descriptive study of acute outbreaks of respiratory disease in Norwegian fattening pig herds | BACKGROUND: Respiratory diseases are major health concerns in the pig production sector worldwide, contributing adversely to morbidity and mortality. Over the past years there was a rise in reported incidents of respiratory disease in pigs in Norway, despite population wide freedom from Aujeszky´s disease, porcine repr... |
Developing a New Normal During the Coronavirus Pandemic | |
Effects of Nasal or Pulmonary Delivered Treatments with an Adenovirus Vectored Interferon (mDEF201) on Respiratory and Systemic Infections in Mice Caused by Cowpox and Vaccinia Viruses | An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201) was evaluated for efficacy against lethal cowpox (Brighton strain) and vaccinia (WR strain) virus respiratory and systemic infections in mice. Two routes of mDEF201 administration were used, nasal sinus (5-µl) and pulmonary (50-µl), to comp... |
Analysis of the association between necrotizing enterocolitis and transfusion of red blood cell in very low birth weight preterm infants | PURPOSE: To investigate the association between necrotizing enterocolitis (NEC) and red blood cell transfusions in very low birth weight (VLBW) preterm infants. METHODS: We studied were 180 VLBW preterm infants who were admitted to the neonatal intensive care unit of CHA Gangnam Hospital from January of 2006 to Decembe... |
Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro | The nucleolus is a nuclear domain involved in the biogenesis of ribosomes, as well as in many other important cellular regulatory activities, such as cell cycle control and mRNA processing. Many viruses, including herpesviruses, are known to exploit the nucleolar compartment during their replication cycle. In a previou... |
Clinical characteristics and outcomes of COVID‐19 patients with gastrointestinal symptoms admitted to Jianghan Fangcang Shelter Hospital in Wuhan, China | OBJECTIVE: Coronavirus disease 2019 (COVID‐19) is a health emergency worldwide, and gastrointestinal (GI) symptoms are increasingly reported in COVID‐19 patients. However, sample size was small and the incidence of GI symptoms in patients was variable across studies, and the correlation between these symptoms and clini... |
Evolution and emergence of novel human infections | Some zoonotic pathogens cause sporadic infection in humans but rarely propagate further, while others have succeeded in overcoming the species barrier and becoming established in the human population. Adaptation, driven by selection pressure in human hosts, can play a significant role in allowing pathogens to cross thi... |
Transforming Positive Pressure Interventional Radiology Suites to Treat COVID-19 Patients | |
Chapter 36 Disseminated Infections A Clinical Overview | The ability of microorganisms to cause infection is governed by multiple different factors – some linked to the microorganisms itself and others to the host or environment. In this chapter we explore some of these factors and provide an overview of disseminated infections examining some important manifestations such as... |
Role of Teleproctoring in Challenging and Innovative Structural Interventions Amidst the COVID-19 Pandemic and Beyond | Abstract Teleproctoring can be used successfully in performing challenging and innovative structural heart interventions using sophisticated technology which allows real time bidirectional audiovisual communication with digital transmission of live videos and direct observation of the operative field by a remote procto... |
Frailty in the Face of COVID-19 | |
Anxiety and coping strategies among nursing students during the covid-19 pandemic | Anxiety is highly prevalent among nursing students even in normal circumstances. In Israel during the covid-19 pandemic and mandatory lockdown, nursing students encountered a new reality of economic uncertainty, fear of infection, challenges of distance education, lack of personal protection equipment (PPE) at work etc... |
Chapter 53 Virus Infection of Airway Epithelial Cells | Abstract The airway epithelial cell barrier serves as the main site of replication for most of the common respiratory viruses and is thereby the first line of defense against these viruses. Host epithelial cells are specially enriched for pattern recognition receptors that activate immune response genes to limit viral ... |
Information and Disinformation: Social Media in the COVID‐19 Crisis | The novel coronavirus disease of 2019 (COVID‐19) is a global pandemic with over 4.7 million cases and 316,000 deaths worldwide.(1) Social media, defined as “electronic communication through which users create online communities to share information, ideas, personal messages, and other content,”(2) has played an importa... |
Association of extended dosing intervals or delays in pembrolizumab-based regimens with survival outcomes in advanced non-small cell lung cancer | BACKGROUND: Besides modeling/simulation-based analysis, no post-approval studies have evaluated optimal administration frequency of pembrolizumab in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: We performed a multicenter retrospective cohort study to evaluate association between survival outcomes and treat... |
Trying Times and Trying Out Solutions: Intimate Partner Violence Screening and Support for Women Veterans During COVID-19 | Initial reports indicate widespread increases in intimate partner violence (IPV) rates during the coronavirus disease 2019 (COVID-19) pandemic. Women veterans are at particular risk for experiencing IPV, and the COVID-19 pandemic and resulting stay-at-home orders may be exacerbating this risk. IPV screening and interve... |
Prevention in COVID-19 time: from failure to future | The COVID-19 pandemic has developed as a consequence of sheer prevention failures, leading in many countries to a sizeable number of deaths and over-saturation of intensive care units. This triggered the imposition of generalisd quarantine (‘lockdown’) of variable stringency in different countries: with the decrease of... |
Nearly full-length genome sequence of a novel astrovirus isolated from chickens with ‘white chicks’ condition | Avian astroviruses (aAstVs) are divided into three species, Avastrovirus 1, Avastrovirus 2, and Avastrovirus 3, but there are a few strains are waiting to be assigned to an official taxonomic group. This study presents the molecular characterization of chicken astrovirus (CAstV), PL/G059/2014, which is involved in the ... |
The perpetuation and epidemic recurrence of communicable diseases in human populations | Abstract Recurrence of communicable diseases is a looming threat for human populations. Factors explaining the recurrences are partially known, involving demographics, biology, and complex relationships with the environment, but no comprehensive theory exists today. Here, we review some recent results obtained in model... |
Economic thoughts on COVID‐19 for Canadian food processors | In this paper, I explore the potential effects of the COVID‐19 pandemic on Canadian food processors. First, COVID‐19 may have an impact on food processing economic activities because of supply and demand shocks. Second, the impact of COVID‐19 on food processing may depend on the type of products and the size of the pro... |
Of chloroquine and COVID-19 | Abstract Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine i... |
Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report | A 17-year-old healthy girl underwent an uneventful esthetic septorhinoplasty. She was easily extubated and transferred to the postanesthesia care unit (PACU) with oxygen saturation (Spo(2)) of 96%. About 30 minutes after arrival in the PACU, she developed dyspnea with Spo(2) of 84% and promptly received oxygen with bil... |
Population‐based study showed that necrotising enterocolitis occurred in space–time clusters with a decreasing secular trend in Sweden | AIM: This study investigated space–time clustering of neonatal necrotising enterocolitis over three decades. METHODS: Space–time clustering analyses objects that are grouped by a specific place and time. The Knox test and Kulldorff's scan statistic were used to analyse space–time clusters in 808 children diagnosed with... |
A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID‐19 | Currently, coronavirus disease 2019 (COVID‐19) is a global pandemic disease with significant morbidity and mortality. Ozone may exert its antiviral actions and ozone therapy has been demonstrated therapeutically usefulness in influenza and novel viruses. In this letter, two severe cases with COVID‐19 received ozone the... |
A Molecularly Imprinted Polymer-Based Technology for Rapid Testing of COVID-19 | The outbreak of COVID-19 has taken a large number of lives since 2019 and the death toll continues to increase all over the world. Recent data reports that about 27 lacs of people are infected with this virus till date and around 2 lacs are dead due to this pandemic. The situation in India is no way better. In India, a... |
Predominance of Human Bocavirus Genotype 1 and 3 in Outpatient Children with Diarrhea from Rural Communities in South Africa, 2017–2018 | Human bocavirus (HBoV) is an emerging virus globally associated with diarrhea in young children. This study aims to investigate the prevalence of HBoV genotypes in children (≤5 years) from rural communities in South Africa (SA) suffering from acute gastroenteritis (AGE). A total of 141 fecal samples of children ≤5 year... |
SARS‐CoV2 and immunosuppression: a double‐edged sword | Severe acute respiratory syndrome Coronavirus 2 (SARS‐Cov2) outbreak has caused a pandemic rapidly impacting on the way of life of the entire world. This impact in the specific setting of transplantation and immunosuppression has been poorly explored to date. Discordant data exist on the impact of previous coronavirus ... |
Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China | BACKGROUND: Healthcare workers fighting against the coronavirus disease 2019 (COVID-19) pandemic are under tremendous pressure, which puts them at an increased risk of developing psychological problems. AIMS: This study aimed to investigate the prevalence of psychological problems in different healthcare workers (ie, p... |
Serological and Molecular Surveillance of Infectious Bronchitis Virus Infection in Free-Range Chickens and Guinea Fowls in the Ga-East District of Ghana | Infectious bronchitis is an economically important disease with worldwide distribution. Information is available on the presence of infectious bronchitis virus in commercial chicken in parts of Ghana but there is no information on free-range poultry and guinea fowls in the country. Possible IBV infections among free-ra... |
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