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README.md
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## Preprocessing Details
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- **Starting cohort**: 985 DepMap cell lines
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- 649 annotated (cancerous)
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## Prompt Design
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### Initial Prompt (
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**Inputs:**
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- Top-10 ranked genes, transcripts, proteins
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- Known PPI and disease–protein relationships
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**Output:**
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- 100 vulnerability genes
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### Refined Prompt (
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**Inputs:**
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- Same as above
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- + Subsignaling gene regulatory network (from graph generator)
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**Output:**
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- Refined 100 vulnerability genes
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---
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**Suggested acknowledgment:**
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> "The results here are in whole or part based upon data generated by the DepMap, Broad Institute of MIT and Harvard."
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---
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## Citation
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If you use this dataset, please cite:
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```bibtex
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@article{zhang2025galax,
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title={GALAX: Graph-Augmented Language Model with Explainability for CRISPR Target Prioritization},
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author={Zhang, Heming and Li, Fuhai and Chen, Yixin and others},
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year={2025},
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journal={Preprint}
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}
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## Preprocessing Details
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- **Starting cohort**: 985 DepMap cell lines
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- 649 annotated (cancerous)
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## Prompt Design
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### Initial Prompt (`P_init_n`)
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**Inputs:**
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- Top-10 ranked genes, transcripts, proteins
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- Known PPI and disease–protein relationships
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**Output:**
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- 100 vulnerability genes `r_init[n,1...100]`
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### Refined Prompt (`P_final_n`)
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**Inputs:**
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- Same as above
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- + Subsignaling gene regulatory network (from graph generator)
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**Output:**
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- Refined 100 vulnerability genes `r_hat[n,1...100]`
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---
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**Suggested acknowledgment:**
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> "The results here are in whole or part based upon data generated by the DepMap, Broad Institute of MIT and Harvard."
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