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2060011557.layout.json
|
[
"SELECTING",
"ADULT",
"SMOKER",
"RESPONDENTS",
"Analysis",
"CCTTS",
"interviews",
"no",
"more",
"than",
"two",
"smokers",
"per",
"household.",
"If",
"there",
"is",
"only",
"one",
"smoker,",
"he/she",
"is",
"selected.",
"If",
"there",
"are",
"two,",
"both",
"are",
"selected.",
"If",
"there",
"are",
"three",
"or",
"more,",
"two",
"are",
"selected,",
"starting",
"with",
"those",
"at",
"home.",
"Up",
"to",
"eight",
"callbacks",
"are",
"made",
"to",
"interview",
"a",
"maximum",
"of",
"two",
"smokers",
"per",
"household.",
"When",
"fewer",
"smokers",
"are",
"inter-",
"viewed",
"than",
"exist,",
"no",
"weighting",
"is",
"applied",
"to",
"represent",
"the",
"smokers",
"not",
"interviewed.",
"This",
"respondent",
"sampling",
"method",
"seriously",
"under-represents",
"smokers",
"who",
"live",
"with",
"two",
"or",
"more",
"other",
"smokers--particularly",
"those",
"less",
"often",
"home",
"during",
"interviewing",
"hours.",
"But",
"it's",
"worse",
"than",
"that.",
"CCTTS",
"selects",
"smokers",
"in",
"this",
"order",
"(up",
"to",
"the",
"maximum",
"of",
"twe):",
"At-home",
"male",
"smokers",
"in",
"ascending",
"age",
"order,",
"At-home",
"female",
"smokers",
"in",
"ascending",
"age",
"order,",
"Not-at-home",
"male",
"smokers",
"in",
"ascending",
"age",
"order",
"(callbacks),",
"W",
"Not-at-home",
"female",
"smokers",
"in",
"ascending",
"age",
"order",
"(callbacks).",
"This",
"is",
"a",
"badly-biased",
"method",
"of",
"respondent",
"selection,",
"in",
"house-",
"holds",
"with",
"more",
"than",
"two",
"smokers.",
"At-homes,",
"males",
"and",
"younger",
"people",
"are",
"of",
"course",
"favored",
"(as",
"intended),",
"in",
"that",
"order.",
"But",
"note",
"the",
"interactions",
"or",
"conditional",
"probabilities,",
"as",
"well:",
"not-at-home",
"smokers",
"interviewed",
"on",
"callback",
"are",
"those",
"where",
"only",
"one",
"or",
"no",
"other",
"smoker",
"was",
"home",
"or",
"cooperated,",
"older",
"males",
"interviewed",
"are",
"those",
"where",
"only",
"one",
"or",
"no",
"youn-",
"ger",
"male",
"smoker",
"was",
"home",
"or",
"cooperated,",
"females",
"interviewed",
"are",
"those",
"where",
"only",
"one",
"or",
"ne",
"male",
"smoker",
"was",
"home",
"or",
"cooperated,",
"older",
"females",
"interviewed",
"are",
"those",
"where",
"only",
"one",
"or",
"no",
"male",
"or",
"younger",
"female",
"smoker",
"was",
"home",
"or",
"cooperated...",
"These",
"are",
"unusual",
"kinds",
"of",
"smokers.",
"Their",
"probabilities",
"of",
"selection",
"are",
"unknown",
"and",
"unknowable.",
"2SSTT00902"
] |
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but00404.64_but00404.66-3.layout.json
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but00404.64_but00404.66-1.layout.json
|
[
"STATEMENT",
"OF",
"David",
"Weeks,",
"M.D.",
"I",
"am",
"a",
"physician",
"practicing",
"general",
"medicine",
"in",
"Boise,",
"Idaho.",
"For",
"the",
"past",
"several",
"years,",
"I",
"have",
"been",
"active",
"in",
"the",
"epidemiology",
"of",
"toxic",
"substances",
"in",
"the",
"indoor",
"air",
"eavironment.",
"[",
"am",
"co-developer",
"of",
"an",
"environmental",
"health",
"data",
"base",
"currently",
"in",
"developmedt",
"with",
"Dr.",
"James",
"Kilpatrick",
"of",
"the",
"Medical",
"College",
"of",
"Virginia.",
"I",
"am",
"here",
"today",
"at",
"the",
"request",
"of",
"The",
"Tobacco",
"Institute",
"to",
"discuss",
"the",
"implications",
"of",
"the",
"IT",
"Corporation’s",
"analysis",
"of",
"cigarette",
"smoke",
"in",
"the",
"air",
"in",
"over",
"70",
"Dallas",
"offices",
"and",
"restaurants.",
"To",
"put",
"it",
"simply:",
"The",
"results",
"of",
"the",
"Dallas",
"study",
"are",
"very",
"clear.",
"The",
"levels",
"of",
"nicotine",
"matter",
"found",
"in",
"local",
"offices",
"and",
"restaurants",
"indicate",
"that",
"smoking",
"regulations",
"are",
"unnecessary",
"in",
"order",
"to",
"assure",
"adequate",
"indoor",
"air",
"quality.",
"The",
"Dailas",
"research",
"should",
"come",
"as",
"a",
"surprise",
"to",
"no",
"studeat",
"of",
"the",
"rapidly-growing",
"field",
"of",
"indoor",
"air",
"quality.",
"Similar",
"results",
"were",
"reported",
"in",
"December",
"1986",
"in",
"a",
"systematic",
"study",
"of",
"air",
"quality",
"in",
"100",
"New",
"Yark",
"City",
"offices",
"and",
"restaurants.",
"What",
"is",
"emerging",
"is",
"an",
"understanding",
"of",
"the",
"true",
"place",
"that",
"environmental",
"tobacco",
"smoke",
"(ETS)",
"has",
"in",
"the",
"complete",
"mixture",
"that",
"we",
"call",
"indoor",
"air",
"quality.",
"TI",
"BU",
"29087"
] |
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508939370_508939517-122.layout.json
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509790579+-0598-17.layout.json
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503850573+-0573.layout.json
|
[
"Subject:",
"Proposed",
"Research",
"on",
"Dual",
"Tow-Item",
"Filters",
"Date:",
"April",
"10,",
"1979",
"To:",
"Dr.",
"M.",
"E.",
"Stowe",
"From:",
"Alan",
"B.",
"Norman",
"Leslie",
"B.",
"Gordon",
".",
"Recently,",
"a",
"dual",
"tow-item",
"filter",
"system",
"was",
"prepared",
"which",
"incorporates",
"high",
"pressure",
"drop",
"with",
"low",
"f11trat1on.",
"Two",
"cigarettes",
"utilizing",
"variations",
"of",
"this",
"filter",
"delivered",
"CO/FTC",
"'tar!",
"ratios",
"of",
"less",
"than",
"0.65",
"while",
"achieving",
"acceptance",
"(vs.",
"True)",
"on",
"the",
"Research",
"Department",
"Booth",
"Panel.",
"The",
"dual",
"filter",
"designs",
"tested",
"thus",
"far",
"dre",
"an",
"improvement",
"over",
"earlier",
"\"low-gas\"",
"filters",
"in",
"that",
"the",
"high",
"dilution/low",
"filtration",
"characteristics",
"are",
"maintained",
"to",
"a",
"large",
"extent,",
"while",
"mouthend",
"draw",
"resistance",
"is",
"much",
"higher",
"for",
"the",
"\"dual",
"filter\".",
"The",
"present",
"dual",
"filter",
"design,",
"however,",
"is",
"based",
"on",
"experience",
"with",
"other",
"single",
"tow",
"item/low-gas",
"delivery",
"filters",
"and",
"is,",
"therefore,",
"not",
"optimized",
"to",
"any",
"degree,",
"The",
"dual",
"tow-item",
"filter",
"appear$",
"to",
"be",
"a",
"viable",
"system",
"for",
"reducing",
"the",
"gas",
"phase",
"delivery",
"of",
"cigarettes",
"while",
"maintaining",
"consumer",
"acceptability.",
"With",
"proper",
"undeistanding",
"and",
"optimizat1on",
"of",
"this",
"filter",
"system,",
"the",
"dual",
"filter",
"should",
"be",
"an",
"fmportant",
"addition",
"to",
"our",
"current",
"low-aas",
"technology.",
"The",
"following",
"study",
"is",
"proposed",
"to",
"increase",
"our",
"understanding",
"of",
"the",
"dual",
"filter:",
"'",
"Investigate",
"the",
"feasibility",
"of",
"manufacturing",
"prototypes",
"from",
"commonly",
"available",
"materials.",
"¢",
"Design",
"and",
"execute",
"a",
"study",
"where",
"the",
"lengths",
"of",
"the",
"two",
"plugs",
"and",
"the",
"denier",
"per",
"filament",
"are",
"varied",
"simultanecusly.",
"\"Smoke",
"analyses,",
"pressure",
"drop",
"and",
"air",
"dilution",
"determinations",
"and",
"taste",
"panel",
"tests",
"would",
"be",
"used",
"as",
"responses.",
"The",
"proposed",
"study",
"would",
"be",
"used",
"to",
"define",
"which",
"tow",
"items",
"and",
"plug",
"lengths",
"are",
"needed",
"for",
"the",
"desired",
"cigaretteiperformance.,",
"In",
"addition,",
"the",
"results",
"of",
"this",
"study",
"would",
"indicate",
"the",
"approximate",
"range",
"of",
"effects",
"the",
"dual",
"filter",
"could",
"produce.",
"Due",
"to",
"current",
"priorities",
"and",
"work",
"plars,",
"a",
"study",
"of",
"this",
"nature",
"could",
"not",
"be",
"initiated",
"and",
"completed",
"in",
"time",
"for",
"the",
"current",
"\"Gori\"",
"product.",
"However,",
"we",
"feel",
"that",
"the",
"dual",
"filter",
"system",
"will",
"be",
"very",
"important",
"in",
"our",
"ongoing",
"gas",
"phase",
"reduction",
"work",
"and",
"that",
"further",
"study",
"of",
"this",
"system",
"should",
"begin",
"as",
"soon",
"as",
"possible.",
"\"",
"L",
"Abr.",
"D.",
"E.",
"Townsend",
".",
"%§",
"Xc:",
"Dr.",
"J.",
"H.",
"Reynolds",
"’",
"€LS0",
"S9E£0S",
"RJR!",
"FORM",
"2422-Roy,",
"72/70",
"&"
] |
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508939370_508939517-2.layout.json
|
[
"January",
"5,",
"1971",
"Page",
"2",
"2.",
"Of",
"ten",
"breeding",
"lines",
"evaluated",
"in",
"the",
"Regional",
"Farm",
"Tests",
"in",
"1970,",
"six",
"met",
"the",
"minimum",
"standards",
"developed",
"by",
"the",
"Variety",
"Evaluation",
"Committee",
"6f",
"the",
"Tobacco",
"Workers",
"Conference.",
"These",
"were",
"Bell",
"110,",
"Coker_68-354-1M,",
"Ga.",
"1498,",
"PD",
"175,",
"Speight.G-33",
"and",
"Va.",
"770,",
"This",
"means",
"that",
"these",
"new",
"varieties",
"have",
"been",
"evaluated",
"for",
"two",
"years",
"in",
"the",
"Regional",
"Small",
"Plots",
"and",
"one",
"year",
"in",
"the",
"Regional",
"Farm",
"Tests",
"and",
"have",
"met",
"the",
"standards",
"as",
"prescribed.",
".This",
"makes",
"26",
"varigties",
"that",
"have",
"met",
"the",
"minimum",
"standards",
"since",
"this",
"program",
"was",
"developed.",
"‘",
"Seed",
"of",
"all",
"varieties",
"that",
"have",
"met",
"the",
"standards",
"may",
"be",
"available",
"for",
"1972",
"planting",
"should",
"the",
"breeder",
"decide",
"to",
"increase",
"them.",
"Bell",
"110",
"was",
"developed",
"by",
"Bell's",
"Seed",
"Farm",
"from",
"a",
"cross",
"of",
"(NC",
"75",
"X",
"C",
"139)",
"X",
"NC",
"95.",
"Coker",
"68-354-1M",
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"by",
"Coker's",
"Pedigreed",
"Seed",
"Company",
"from",
"a",
"cross",
"of",
"(Coker",
"258",
"X",
"C-319)",
"X",
"C-319,",
"Georgia",
"1498",
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"by",
"Georgia",
"Agricultural",
"Experiment",
"Station",
"from",
"a",
"cross",
"of",
"MS",
"Hicks",
"(Un)",
"X",
"65-61.",
"\"",
"PD",
"175",
"was",
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"by",
"Pee",
"Dee",
"Experiment",
"Station",
"of",
"Florence,",
"South",
"Carolina",
"from",
"a",
"cross",
"of",
"(NC",
"95",
"X",
"C",
"139)",
"X",
"Mos,",
"Res.",
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"by",
"Speight",
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"Company",
"from",
"a",
"cross",
"of",
"(Coker",
"187",
"X",
"Vesta",
"30)",
"X",
"NC",
"95.",
">",
"Va.,",
"770",
"was",
"developed",
"by",
"VPI",
"from",
"a",
"cross",
"of",
"NC",
"95",
"X",
"Va.",
"3160.",
"These",
"entries",
"represent",
"a",
"wide",
"range",
"of",
"chemical,",
"physical,",
"and",
"smoke",
"characteristics",
"as",
"well",
"as",
"disease",
"reaction.,",
"They",
"offer",
"to",
"the",
"farmer",
"a",
"choice",
"of",
"variety",
"types",
"and",
"disease",
"resistance.",
"Va.",
"770",
"and",
"PD",
"175",
"are",
"the",
"first",
"entries",
"to",
"offer",
"resistance",
"to",
"Mosaic.",
"3.",
"Six",
"lines",
"met",
"the",
"minimum",
"standards",
"in",
"the",
"Regional",
"Small",
"Plot",
"Tests",
"in",
"1970",
"and",
"will",
"be",
"advanced",
"to",
"the",
"Regional",
"Farm",
"Tests",
"for",
"1971,",
"They",
"are",
"NC",
"8855,",
"NC",
"8090,",
"Speight",
"G-140,",
"PD",
"79,",
"McNair",
"944",
"and",
"Va.",
"9163,",
"4,",
"The",
"Standards",
"Committee",
"has",
"revised",
"the",
"standards",
"relative",
"to",
"the",
"range",
"for",
"certain",
"chemical",
"and",
"physical",
"constituents",
"in",
"a",
"report",
"datéd",
"March",
"1970.",
"A",
"news",
"release",
"on",
"the",
"results",
"of",
"the",
"Variety",
"Evaluation",
"Committee",
"findings",
"will",
"be",
"made",
"March",
"1,",
"1971.",
"Appreciation",
"is",
"expressed",
"to",
"the",
"new",
"committee",
"for",
"its",
"active",
"participation",
"and",
"deliberation",
"in",
"carrying",
"out",
"the",
"functions",
"of",
"this",
"program.",
"There",
"was",
"CLE6",
"£680§"
] |
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521115419+-5436-16.layout.json
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531376115+-6129-3.layout.json
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[
"News",
"Report",
"May",
"6,",
"1997",
"China",
"CHINA'S",
"ToBACCO",
"FIRMS",
"PREPARE",
"TO",
"COMPETE",
"Only",
"a",
"few",
"dozen",
"of",
"China’s",
"2,000",
"tobacco-processing",
"factories",
"would",
"be",
"able",
"to",
"stand",
"up",
"to",
"international",
"competition",
"if",
"restrictions",
"on",
"foreign",
"investment",
"were",
"lifted,",
"said",
"Zhou",
"Ruizeng,",
"director",
"of",
"the",
"General",
"Office",
"of",
"the",
"State",
"Tobacco",
"Monopoly",
"Administration,",
"or",
"STMA.",
"Many",
"companies",
"would",
"lose",
"money",
"and",
"many",
"people",
"could",
"face",
"unemployment",
"if",
"the",
"state",
"monopoly",
"were",
"to",
"be",
"broken",
"up—a",
"possibility",
"given",
"China’s",
"desire",
"to",
"enter",
"the",
"World",
"Trade",
"Organization.",
"The",
"looming",
"competition",
"has",
"led",
"the",
"STMA",
"to",
"begin",
"a",
"drastic",
"restructuring",
"plan,",
"Mr.",
"Zhou",
"said,",
"forcing",
"factories",
"out",
"of",
"tobacco",
"products",
"and",
"to",
"invest",
"in",
"fields",
"as",
"diverse",
"as",
"tourism,",
"printing",
"and",
"automobiles.",
"Mr.",
"Zhou",
"said",
"that",
"at",
"this",
"point",
"only",
"the",
"largest",
"tobacco",
"factories",
"would",
"be",
"able",
"to",
"stand",
"up",
"to",
"competition.",
"He",
"said",
"70",
"of",
"the",
"2,000",
"factories",
"had",
"more",
"than",
"1,000",
"employees,",
"and",
"that",
"only",
"about",
"half",
"of",
"the",
"70",
"would",
"be",
"capable",
"of",
"competing",
"internationally.",
"Tobacco",
"companies",
"paid",
"$9",
"billion",
"in",
"taxes",
"to",
"the",
"central",
"government,",
"he",
"said,",
"and",
"made",
"profits",
"of",
"$1.5",
"billion.",
"China’s",
"tobacco",
"factories,",
"including",
"cigarette",
"manufacturers,",
"packaging",
"and",
"leaf",
"processing,",
"employ",
"500,000",
"people.",
"Source:",
"The",
"Asian",
"Wall",
"Street",
"Journal;",
"02-May-97",
"CHINA",
"LOWERS",
"TAXES",
"ON",
"IMPORTED",
"CIGARETTES",
"BEIJING,",
"May",
"6",
"(Itar-Tass)",
"The",
"Chinese",
"Finance",
"Ministry",
"has",
"announced",
"that",
"the",
"consumer",
"tax",
"on",
"imported",
"cigarettes",
"would",
"be",
"lowered",
"before",
"the",
"end",
"of",
"this",
"year.",
"It",
"is",
"endeavoring",
"in",
"this",
"way",
"to",
"prevent",
"the",
"further",
"expansion",
"of",
"contraband",
"trade,",
"as",
"a",
"result",
"of",
"which",
"the",
"treasury",
"loses",
"more",
"than",
"1.8",
"billion",
"U.S.",
"dollars",
"in",
"taxes",
"every",
"year.",
"China",
"is",
"the",
"world’s",
"leading",
"producer",
"and",
"consumer",
"of",
"tobacco.",
"There",
"are",
"350",
"million",
"smokers",
"in",
"the",
"country.",
"More",
"than",
"1.7",
"trillion",
"cigarettes",
"were",
"sold",
"there",
"last",
"year.",
"Parallel",
"with",
"this,",
"it",
"is",
"planned",
"to",
"boost",
"taxes",
"on",
"Chinese-made",
"alcoholic",
"drinks",
"in",
"order",
"to",
"prevent",
"the",
"“squandering",
"of",
"grain”",
"and",
"to",
"promote",
"a",
"sober",
"way",
"of",
"life.",
"The",
"country’s",
"10,000",
"wineries",
"and",
"vodka",
"distilleries",
"have",
"used",
"up",
"in",
"1996",
"fourteen",
"million",
"tonnes",
"of",
"grain.",
"This",
"amount",
"is",
"sufficient",
"to",
"feed",
"all",
"the",
"population",
"of",
"such",
"megapolises",
"as",
"Beijing",
"and",
"Shanghai",
"combined",
"for",
"a",
"period",
"of",
"one",
"whole",
"year.",
"The",
"output",
"of",
"alcoholic",
"drinks",
"has",
"grown",
"by",
"more",
"than",
"three",
"per",
"cent",
"in",
"the",
"country,",
"reaching",
"6.8",
"million",
"tonnes.",
"in",
"spite",
"of",
"Premier",
"Li",
"Peng’s",
"recent",
"call",
"to",
"drink",
"chiefly",
"light",
"fruit",
"wines,",
"The",
"premier",
"warned",
"his",
"fellow-countrymen",
"that",
"“corruption",
"often",
"springs",
"from",
"the",
"bottom",
"of",
"a",
"wine",
"glass.”",
"Source:",
"OTC",
"5/6/97",
"3:26",
"AM",
"RJR0000000026006822",
"70052",
"1973",
"8L19",
"ZE1€S"
] |
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0071036180.layout.json
|
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10175066_10175068-0.layout.json
|
[
"/L(",
"CREIGHTON",
"UNiversiTy",
"HKB1838104",
"Schoo!",
"of",
"Meducine",
"‘",
")",
"L-,;r‘",
"January",
"28,1976",
"William",
"Gardner,",
"Ph.D.,",
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"Director",
"Council",
"for",
"Tobacco",
"Research",
"—",
"U.S.A.",
"110",
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"59th",
"Street",
"New",
"York;",
"New",
"York",
"10022",
"Re:",
"Kenneth",
"Paigen,",
"PHD.",
"%",
"|",
"entitled",
"“A",
"Genetic",
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"of",
"Glucuronidase",
"Bladder",
"Cancer”,",
"No.",
"1080",
"Dear",
"Bill:",
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"bladder",
"cancer.",
"The",
"disease",
"itself",
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"the",
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"levels.",
"The",
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"these",
"difficulties",
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"using",
"a",
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"leam",
"whether",
"individuals",
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"high",
"urinary",
"glucuronidase",
"levels",
"are",
"more",
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"urinary",
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"bladder",
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"patients",
"will",
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"cancer",
"patientc",
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"glucuronidase.",
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"that",
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"he",
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"urinary",
"glocuronidase",
"levels",
"in",
"bladder",
"cancer",
"patients",
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"due",
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"an",
"autosomal",
"recessive",
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"and",
"therefore",
"the",
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"children",
"would",
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"to",
"the",
"heterozygous",
"state",
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"as",
"this",
"alleged",
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"is",
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"has",
"long",
"been",
"known",
"to",
"etiologically",
"related",
"to",
"bladder",
"cancer",
"in",
"humans.",
"Bilharzissis",
"also",
"causes",
"an",
"elevation",
"of",
"urinary",
"glucuronidase,",
"Again",
"it",
"is",
"not",
"clear",
"whether",
"the",
"bladder",
"cancer",
"itself",
"elevates",
"the",
"urinary",
"glacuronidase",
"in",
"this",
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"these",
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"glucuronidase",
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".",
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"author",
"conducted",
"a",
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"study",
"using",
"three",
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"urine",
"samples",
"from",
"fifteen",
"monozygotic",
"and",
"fifteen",
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"the",
"studies",
"in",
"mice",
"were",
"in",
"support",
"of",
"genetic",
"etiology",
"for",
"glucuronidase."
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"last",
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"you",
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"to",
"take",
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"next",
"hour",
"to",
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"that.",
"I",
"am",
"going",
"to",
"lead",
"off,",
"and",
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"for",
"15",
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"or",
"so",
"about",
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"our",
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"follow",
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"a",
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2046807567_7643-2.layout.json
|
[
"17:16",
"637",
"15035",
"PHEILIP",
"NORRiS",
"€O",
"OVERVIEW",
"GENERAL",
"ISSUES",
"In",
"response",
"to",
"requests",
"from",
"Congress,",
"this",
"report",
"presents",
"an",
"analysis",
"of",
"the",
"potential",
"health",
"effects",
"of",
"environmental",
"tobacco",
"smoke",
"(ETS).",
"The",
"report",
"concentrates",
"on",
"possible",
"lung",
"cancer",
"risk",
"because",
"of",
"the",
"gvailability",
"of",
"published",
"literature",
"and",
"resource",
"constraints",
"within",
"CRS.",
"A",
"brief",
"overview",
"of",
"ETS",
"and",
"the",
"risk",
"of",
"heart",
"disease",
"and",
"childhood",
"respiratory",
"illness",
"is",
"also",
"presented.",
"A",
"substantial",
"body",
"of",
"evidence",
"built",
"up",
"over",
"the",
"last",
"40",
"years",
"indicates",
"that",
"smoking",
"is",
"a",
"major",
"cause",
"of",
"illness",
"and",
"premature",
"death.",
"In",
"recent",
"years,",
"several",
"reports",
"have",
"also",
"concluded",
"that",
"exposure",
"to",
"environmental",
"tobacco",
"smoke",
"(ETS)",
"can",
"cause",
"lung",
"cancer",
"in",
"people",
"who",
"have",
"never",
"smoked.",
"In",
"1992,",
"the",
"Environmental",
"Protection",
"Agency",
"(EPA)",
"classified",
"ETS",
"as",
"a",
"known",
"human",
"carcinogen",
"and",
"estimated",
"that",
"ETS",
"exposure",
"is",
"responsible",
"for",
"about",
"3000",
"lung",
"cancer",
"deaths",
"each",
"year",
"among",
"adult",
"nonsmokers.",
"EPA’s",
"findings",
"have",
"received",
"much",
"support",
"from",
"the",
"scientific",
"community,",
"but",
"have",
"been",
"criticized",
"by",
"other",
"seientists",
"the",
"tobacco",
"industry.",
"Environmental",
"tobacco",
"smoke",
"is",
"a",
"highly",
"diluted",
"combination",
"of",
"mainstream",
"smoke",
"exhaled",
"by",
"smokers",
"and",
"sidestream",
"smoke",
"released",
"directly",
"from",
"the",
"burning",
"tips",
"of",
"cigarettes.",
"Researchers",
"have",
"concluded",
"that",
"ETS",
"contains",
"most,",
"if",
"not",
"all,",
"of",
"the",
"carcinogenic",
"and",
"toxic",
"compounds",
"that",
"are",
"present",
"in",
"mainstream",
"smoke.",
"Studies",
"that",
"mesasured",
"cotinine",
"a",
"nicotine",
"derivative",
"—",
"levels",
"in",
"blood",
"and",
"urine",
"indicate",
"that",
"there",
"is",
"widespread",
"exposure",
"to",
"ETS,",
"and",
"measurable",
"uptake",
"of",
"ETS",
"by",
"nonsmokers.",
"According",
"to",
"the",
"EPA,",
"ihe",
"chemical",
"similarities",
"between",
"mainstream",
"smoke",
"and",
"ETS,",
"and",
"the",
"evidence",
"of",
"exposure",
"to,",
"and",
"uptake",
"of,",
"ETS",
"ameng",
"nonsmokers",
"is",
"sufficient",
"to",
"eonclude",
"that",
"ETS",
"is",
"a",
"lung-cancer",
"hazard.",
"The",
"EPA",
"based",
"its",
"estimate",
"of",
"the",
"magnitude",
"of",
"the",
"ETS",
"Iung",
"cancer",
"risk",
"among",
"nonsmokers",
"on",
"an",
"analysis",
"of",
"over",
"30",
"epidemiologic",
"studies",
"of",
"lung",
"cancer",
"among",
"adult",
"non-smoking",
"women.",
"These",
"studies",
"relied",
"on",
"spousal",
"smoking",
"as",
"a",
"surrogate",
"for",
"ETS",
"exposure",
"and",
"classified",
"the",
"women",
"as",
"exposed",
"or",
"unexposed",
"on",
"the",
"basis",
"of",
"whether",
"their",
"iusbands",
"smoked.",
"The",
"lung",
"cancer",
"risk",
"among",
"the",
"exposed",
"women",
"was",
"compared",
"to",
"that",
"of",
"the",
"unexposed",
"women.",
"Since",
"the",
"EPA",
"report",
"was",
"issued,",
"the",
"largest",
"and",
"most",
"recent",
"case-control",
"epidemiclogic",
"study",
"included",
"in",
"the",
"EPA",
"findings",
"has",
"been",
"completed,",
"and",
"three",
"other",
"large,",
"case-control",
"have",
"been",
"published.",
"Two",
"of",
"these",
"studies!",
"shew",
"ne",
"increased",
"risk,",
"one?",
"shows",
"a",
"statistically",
"significant",
"incressed",
"risk",
"while",
"the",
"!",
"Kabat,",
"G,",
"etal,",
"American",
"Journal",
"of",
"Epidemislogy,",
"Vol.142,",
"No.2,",
"1993,",
"p.141-148;",
"Brownson.R.C.,",
"et.al,,",
"Americon",
"Journal",
"of",
"Public",
"Health,",
"Vel.82,",
"No.1},",
"1992,",
"p.1525-1530.",
"2",
"Fontham,",
"E.T.H,",
"et.al.Journal",
"of",
"the",
"Ameriean",
"Medical",
"Association,",
"Val.271,No.22,",
"1554,",
"£.1752-1759.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"@003,03%",
"69G.089V0¢"
] |
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530281903+-1903.layout.json
|
[
"D0,",
"W/’",
"Dianne",
"M,",
"Neal",
"&",
"Director,",
"Financial",
"Company",
"Planning",
"and",
"Accounting",
"Extension",
"2978",
"INTEROFFICE",
"MEMORANDUM",
"DATE:",
"August",
"14,",
"1996",
"TO:",
"Rich",
"Russell",
"SUBJECT:",
"CAMEL's",
"Share",
"of",
"Smoker",
"Rich,",
"attached",
"are",
"the",
"CAMEL",
"share",
"of",
"smoker",
"numbers",
"for",
"Q2",
"1996.",
"The",
"attached",
"excel",
"file",
"has",
"two",
"tabs,",
"“18-24",
"Graph”",
"and",
"“Total",
"Graph”.",
"The",
"first",
"graph",
"shows",
"the",
"individual",
"and",
"rolling",
"average",
"share",
"among",
"18-24",
"year",
"old",
"smokers.",
"Please",
"note",
"that",
"there",
"was",
"a",
"steep",
"decline",
"in",
"CAMEL’s",
"share",
"among",
"this",
"group",
"in",
"the",
"most",
"recent",
"quarter.",
"Because",
"of",
"the",
"small",
"sample",
"size",
"for",
"this",
"group",
"there",
"is",
"substantial",
"statistical",
"variability",
"around",
"this",
"number",
"(+",
"or",
"1.6%).",
"While",
"the",
"change",
"versus",
"Q1",
"exceeds",
"this",
"level",
"(-2.3%),",
"we",
"believe",
"this",
"to",
"be",
"an",
"aberration",
"and",
"not",
"truly",
"representative",
"of",
"marketplace",
"performance.",
"The",
"second",
"graph",
"provides",
"rolling",
"four",
"quarter",
"information",
"for",
"various",
"age",
"groups",
"since",
"Q4",
"1993.",
"We",
"believe",
"this",
"provides",
"a",
"better",
"representation",
"of",
"what",
"is",
"truly",
"the",
"long-term",
"trend",
"for",
"CAMEL.",
"It",
"reflects",
"stronger",
"share",
"and",
"stability",
"among",
"the",
"18-24",
"age",
"group,",
"steady",
"growth",
"among",
"the",
"25-34",
"age",
"group",
"and",
"stability",
"in",
"the",
"35+",
"age",
"group.",
"While",
"we",
"believe",
"the",
"second",
"quarter",
"share",
"for",
"CAMEL",
"is",
"an",
"aberration,",
"be",
"assured",
"that",
"RJRT",
"will",
"continue",
"to",
"watch",
"this",
"closely",
"to",
"ensure",
"that",
"if",
"it",
"is",
"a",
"change",
"in",
"marketplace",
"performance,",
"we",
"will",
"react.",
"Thank",
"you",
"and",
"please",
"let",
"me",
"know",
"if",
"you",
"would",
"like",
"to",
"discuss",
"this",
"further.",
"Dianne",
"attachments",
"RJR0000000413073359",
"70043",
"5093",
"€061",
"820¢g"
] |
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2046807567_7643-44.layout.json
|
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"+he",
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"little",
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"uncertainties",
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"lung",
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"—",
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"exposure",
"£o",
"ETS",
"by",
"PRAFT",
"SUBJECT",
"TO",
"REVISION,",
"NOT",
"¥OR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"Qoo7-033",
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508939370_508939517-108.layout.json
|
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504989552_504989561-2.layout.json
|
[
"First,",
"legislation",
"in",
"this",
"area",
"is",
"simply",
"unnecessary.",
"Federal",
"departments",
"and",
"agencies",
"thaé",
"wish",
"to",
"restrict",
"smoking",
"have",
"proceeded",
"to",
"do",
"sd",
"without",
"seeking",
"specific",
"legislative",
"authority.",
"Furthermore,",
"we",
"detect",
"no",
"evidence",
"of",
"any",
"great",
"demand",
"for",
"legislation",
"which",
"would",
"restrict",
"smoking",
"in",
"the",
"workplace.",
"No",
"substantial",
"segment",
"of",
"the",
"Federal",
"workforce",
"=--",
"certainly",
"no",
"Federal",
"employee",
"labor",
"organization",
"that",
"we",
"are",
"\"",
"aware",
"of",
"is",
"asking",
"for",
"enactment",
"of",
"legislation",
"like",
"S.",
"1440.",
"Second,",
"the",
"major",
"premises",
"or",
"'\"findings'",
"of",
"the",
"bill",
"are",
"not",
"facts",
"but",
"rather",
"assertions",
"that",
"have",
"been",
"rebutted",
"by",
"eminent",
"scientists,",
"econofiistsrand",
"leg;liéghéiaféli7T;£;;;oréééké",
"ififiéfie",
"indoor",
"environment",
"has",
"not",
"been",
"shown",
"to",
"be",
"a",
"significant",
"health",
"hazard.",
"It",
"has",
"not",
"been",
"demonstrated",
"that",
"smoking",
"results",
"in",
"increased",
"costs",
"to",
"employers.",
"Similarly,",
"this",
"legislation",
"ié",
"not",
"required",
"by",
"court",
"decisions.",
"Third,",
"S.",
"1440",
"would",
"burden",
"the",
"Government",
"with",
"unmanagéable",
"and",
"unenforceable",
"regulations",
"and",
"the",
"American",
"taxpayer",
"with",
"excessive",
"and",
"unnecessary",
"costs.",
"Finally,",
"the",
"legislation",
"would",
"tend",
"to",
"polarize",
"Federal",
"employees,",
"and",
"thus",
"lower",
"morale",
"and",
"productivity.",
"In",
"short,",
"Mr.",
"Chairman,",
"and",
"with",
"all",
"due",
"respect,",
"we",
"believe",
"that",
"S.",
"1440",
"is",
"a",
"solution",
"in",
"search",
"of",
"a",
"problem,",
"and",
"a",
"flawed",
"solution",
"at",
"that.",
"Let",
"me",
"be",
"more",
"specific:",
"In",
"late",
"1984,",
"the",
"Human",
"Resources",
"Policy",
"Corporation",
"surveyed",
"1,100",
"of",
"the",
"nation's",
"largest",
"and",
"fastest-growing",
"firms.",
"It",
"looked",
"at",
"workplace",
"smoking",
"policies",
"in",
"the",
"private",
"sector.",
"Here's",
"what",
"it",
"found:",
"Page",
"2",
"nsse",
"86HCS",
"~e"
] |
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"Plaase",
"tell",
"me",
"the",
"category",
"which",
"best",
"reprasants",
"all",
"tha",
"money",
"the",
"members",
"of",
"your",
"Feusehold",
"sarned",
"or",
"recsived,",
"such",
"as",
"salaries,",
"tips,",
"commissions,",
"bonuses,",
"or",
"any",
"investment",
"income",
"in",
"~333.",
"Less",
"than",
"$10,000",
".",
"1",
".",
".",
"(READ",
"LIST}",
".",
".",
"e",
"Black",
"2",
"Hispanic",
".",
"3",
"a",
"A",
"of",
"some",
"other",
"ethric",
"group",
".",
".5",
"(DO",
"NOT",
"READI—»",
"Refson",
"R",
"510,000",
"under",
"$20,000",
".",
"..",
"e",
".2",
"520,000",
"under",
"$30,000",
".",
"3",
"$30,000",
"under",
"$40,000",
".",
"4",
"340,000",
"under",
"$50,000",
".",
"..",
"5",
"$50,000",
"or",
"mare",
"e",
"6",
"{DO",
"NOT",
"READ)M-—+",
".",
"Don‘tknow",
".............",
".",
"X",
"NOT",
"Refused",
"..",
"A",
"And",
"finally,",
"1o",
"ba",
"sure",
"we",
"have",
"talked",
"to",
"a",
"broad",
"mix",
"of",
"peopla",
"in",
"your",
"area,",
"would",
"you",
"please",
"2",
".",
"me",
"if",
"(INTERVIEWER",
"NOTE:",
"RECORD",
"GENOER",
"OF",
"RESPONDENT)",
"Male...",
"1",
"Femae",
"..",
"2",
"I'd",
"to",
"thank",
"you",
"Tor",
"your",
"helo",
"tuday.",
"May",
"|",
"verify",
"that",
"|",
"reached",
"yau",
"by",
"dialing",
"(PRESS",
"TAB",
"«",
"anCNE",
"NO.)",
"Qnce",
"again,",
"thank",
"you",
"very",
"mucn",
"ter",
"yaur",
"time",
"and",
"have",
"o",
"pleasant",
"evening,",
"465317483"
] |
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10175066_10175068-2.layout.json
|
[
"J",
"mng",
"1976",
"HKB7838106¢",
"William",
"Gardner,",
"Ph.D.,",
"Scientific",
"Dirzctor",
"Council",
"for",
"Tobacco",
"Research",
"—",
"U.S.A.",
"re:",
"Kenneth",
"Paigen,",
"Ph.D.",
"One",
"of",
"the",
"major",
"concerns",
"in",
"this",
"project",
"relates",
"to",
"the",
"hypothesis",
"of",
"Paigen’s",
"which",
"suggests",
"that",
"urinary",
"bladder",
"cancer",
"may",
"have",
"a",
"genetic",
"susceptibility",
"and",
"furthermore,",
"that",
"this",
"suscepubdlty",
"may",
"be",
"directly",
"related",
"to",
"the",
"inheritance",
"of",
"glucuronidase.",
"The",
"fact",
"of",
"the",
"matter",
"is",
"that",
"bladder",
"cancer",
"has",
"been",
"shown",
"to",
"occur",
"on",
"a",
"familial",
"basis",
"in",
"exoeedmgly",
"rare",
"circumstances.",
"Indeed",
"the",
"only",
"family",
"I",
"was",
"able",
"to",
"find",
"in",
"my",
"own",
"review",
"of",
"the",
"subject",
"is",
"that",
"reported",
"by",
"Fraumeni",
"and",
"Thomas",
"which",
"involved",
"the",
"occurn'enoe",
"of",
"urinary",
"bladder",
"cancer",
"in",
"a",
"man",
"and",
"his",
"three",
"sons.",
"A",
"study",
"by",
"Morganti",
"and",
"amocxates",
"of",
"160",
"patients",
"with",
"urinary",
"bladder",
"cancer",
"compared",
"with",
"160",
"matched",
"controls",
"failed",
"to",
"reveal",
"any",
"significant",
"familial",
"factor",
"existing",
"in",
"this",
"lesion.",
"I",
"am",
"enclosmg",
"a",
"brief",
"review",
"of",
"the",
"subject",
"including",
"the",
"appropriate",
"references",
"which",
"appear",
"in",
"my",
"recently",
"published",
"book",
"entitled",
"“Cancer",
"Genetics”",
"—",
"Charles",
"C.",
"Thomas,",
"l‘ubhshers,",
"1976.",
"In",
"light",
"of",
"this",
"fact,",
"I",
"senously",
"question",
"whether",
"any",
"meaningful",
"results",
"will",
"be",
"obtained",
"from",
"the",
"study",
"of",
"progeny.of",
"bladder",
"cancer",
"patients.",
"However,",
"the",
"model",
"that",
"Dr.",
"Paigen",
"has'",
"developed",
"appears",
"to",
"be",
"sound",
"and",
"because",
"of",
"the",
"signi-",
"ficance",
"of",
"this",
"work",
"should",
"positive",
"findings",
"be",
"observed,",
"I",
"would",
"give",
"this",
"proposal",
"favoratile",
"consideration",
"with",
"moderate",
"priority.",
"Sincefi!]y.",
"Professor",
"an",
"G\\mrman",
"Departinent",
"dfPreventive",
"Medicine",
"&",
"Public",
"Health",
"enclosure:",
"HTL/mib"
] |
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"all",
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"by",
"the",
"manufacturer",
"(whether",
"by",
"means",
"of",
"coupons,",
"stickers,",
"buy-downs,",
"rebates,",
"concessions,",
"gifts,",
"or",
"otherwise),",
"intended",
"as",
"a",
"contribution",
"to",
"the",
"retail",
"price",
"paid",
"by",
"a",
"consumer,",
"shall",
"be",
"included",
"in",
"the",
"calculation",
"of",
"the",
"price",
"received.",
"The",
"director",
"shall",
"not",
"promulgate",
"or",
"enforce",
"any",
"requirement",
"or",
"prohibition",
"with",
"respect",
"to",
"such",
"payments",
"or",
"any",
"promotional",
"sales",
"plan",
"utilizing",
"such",
"payments",
"that",
"is",
"not",
"expressly",
"specified",
"in",
"this",
"section.",
"Notes:",
"Regulations",
"Yes.",
"See",
"especially",
"N.J.",
"Adm.",
"Code",
"§",
"18:6-4.1",
"(manufacturer",
"promotional",
"programs",
"subject",
"to",
"the",
"provisions",
"of",
"the",
"New",
"Jersey",
"Unfair",
"Cigarette",
"Sales",
"Act",
"and",
"related",
"regulations)",
"and",
"also",
"§",
"18:6-4.3,",
"specifying:",
"(a)",
"Every",
"manufacturer’s",
"promotional",
"sales",
"plan",
"is",
"to",
"be",
"universal",
"and",
"is",
"to",
"be",
"made",
"available",
"simultaneously",
"and",
"on",
"equal",
"terms",
"to",
"each",
"and",
"every",
"licensed",
"retailer",
"dealing",
"in",
"the",
"sponsoring",
"manufacturers’",
"products.",
"0050",
"8vzzs"
] |
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tob12300.37_tob12300.40-0.layout.json
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"women",
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"relatively",
"little",
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"—",
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"LITIGATION",
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2046807567_7643-18.layout.json
|
[
"17:24",
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"or",
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"the",
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"vapor",
"phase",
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"the",
"deposition",
"of",
"particles",
"inside",
"respiratory",
"passageways.",
"Based",
"on",
"these",
"considerations,",
"an",
"ETS",
"chemist",
"concjuded",
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"_the_evidence",
"for",
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"questionabie",
"—Deciding-that",
"ETS",
"js",
"2",
"lung",
"carcinogen",
"still",
"leaves",
"unanswerel",
"e",
"question:",
"How",
"great",
"a",
"cancer",
"risk",
"do€s",
"Hasaive",
"srmoking",
"pose?Researchory",
"trve",
"GEed",
"nicohine",
"rressurements",
"to",
"caleulate",
"ETS",
"exposure",
"in",
"terms",
"of",
"cigarette",
"equivalents,",
"by",
"estimating",
"the",
"number",
"of",
"cigarettes",
"one",
"would",
"have",
"to",
"smoke",
"to",
"receive",
"the",
"same",
"amount",
"of",
"nicotine",
"as",
"breathing",
"ETS",
"in",
"a",
"particular",
"environment",
"for",
"a",
"given",
"period",
"of",
"time.*",
"For",
"example,",
"the",
"amount",
"of",
"nicotine‘",
"inhaled",
"by",
"a",
"nonsmoker",
"working",
"in",
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"relatively",
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"for",
"eight",
"hours",
"is",
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"smoking",
"one-eighth",
"of",
"2",
"cigarette.%",
"=",
"See,",
"for",
"example,",
"testimony",
"presented",
"by",
"Dr.",
"Dauglas",
"Dockery,",
"Haxvard",
"Schoeol",
"of",
"Public",
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"or.",
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"21,",
"1893,",
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"the",
"House",
"Committee",
"on",
"Agricultuse,",
"Subcommittee",
"on",
"Spacialty",
"Crops",
"and",
"Natural",
"Resources.",
"28",
"Testimony",
"presacted",
"by",
"Dr.",
"Michzel",
"Guarin,",
"Oak",
"Ridge",
"National",
"Laboratory,",
"at",
"the",
"July",
"21",
"ETS",
"hearing.",
"28",
"The",
"formula",
"for",
"eigarette",
"equivalents",
"=",
"amount",
"from",
"ETS",
"exposure/amount",
"{rom",
"smoking",
"one",
"cigarette.",
"3",
"secumes",
"an",
"average",
"nicotine",
"concezwation",
"of",
"18",
"ug[ma‘",
"Exposures",
"longer",
"than",
"8",
"hours",
"would",
"lead",
"to",
"proportionately",
"higher",
"cigarette",
"equivalsnts,",
"as",
"would",
"higher",
"breathing",
"rates",
"resulting",
"from",
"physical",
"exertion",
"at",
"worx.",
"Based",
"on",
"calculations",
"presented",
"in",
"Hammond",
"et",
"al,",
"1995",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"CR",
"ATTRIBUTION.",
"G8GLOBIVOC"
] |
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2060011560.layout.json
|
[
"Optimum",
"Allocation",
"by",
"Time-Zone",
"Interview",
"yield",
"varies",
"greatly",
"over",
"Time-Zones,",
"in",
"terms",
"of",
"the",
"number",
"of",
"adults",
"located",
"and",
"number",
"of",
"smokers",
"interviewed,",
"per",
"1,000",
"RDD",
"numbers",
"dialled.",
"At",
"present,",
"the",
"survey",
"companies",
"are",
"trying",
"to",
"meet",
"Time-Zone",
"\"contact\"",
"guotas",
"in",
"various",
"ad",
"hoc,",
"expedient",
"ways",
"that",
"raise",
"costs",
"and",
"violate",
"probability",
"sampling",
"principles",
"(see",
"\"SAMPLE",
"REPLICATES\",",
"below).",
"We",
"recommend",
"eliminating",
"\"contact",
"quotas\"",
"(and",
"all",
"other",
"quotas)",
"completely.",
"Instead,",
"select",
"the",
"original",
"RDD",
"sample",
"dispropor-",
"tionally",
"by",
"Time-Zone,",
"to",
"compensate",
"the",
"different",
"Zone",
"yield",
"rates,",
"so",
"that",
"sample",
"adults",
"distribute",
"over",
"Time-Zones",
"proportion-",
"ally",
"to",
"Census.",
"(We",
"have",
"recommended",
"recording",
"all",
"adults",
"that",
"exist",
"in",
"sample",
"households,",
"and",
"we",
"now",
"must",
"use",
"\"adults\"",
"because",
"there",
"are",
"no",
"Census",
"data",
"for",
"\"smokers\".)",
"Use",
"past",
"\"yield\"",
"data,",
"by",
"month",
"or",
"season",
"of",
"the",
"year,",
"to",
"estimate",
"how",
"many",
"RDD",
"numbers",
"to",
"pick",
"in",
"each",
"Time-Zone",
"so",
"that",
"sample",
"\"adults\"",
"distribute",
"over",
"Time-Zones",
"about",
"proportionally",
"to",
"Census.",
"Accept",
"the",
"distribution",
"that",
"results",
"each",
"month:",
"the",
"recommended",
"weighting",
"to",
"match",
"\"sample",
"adults\"",
"to",
"\"Census",
"adults\"",
"includes",
"Time-Zone.,",
"Correct",
"the",
"selection",
"of",
"future",
"RDD",
"numbers",
"by",
"Zone,",
"from",
"experience,",
"We",
"know",
"for",
"each",
"\"adult\"",
"whether",
"he",
"is",
"a",
"\"smoker\"",
"or",
"not.",
"Those",
"who",
"are",
"smokers",
"we",
"call",
"\"smokers",
"that",
"exist\",",
"to",
"distinguish",
"them",
"from",
"\"smokers",
"interviewed\".",
"Matching",
"\"adults\"",
"to",
"Census",
"automatically",
"gives",
"the",
"distributions",
"of",
"\"smokers",
"that",
"exist\"",
"by",
"sex,",
"age,",
"week-within-month",
"and",
"Time-",
"Zone",
"(since",
"\"smokers",
"that",
"exist\"",
"are",
"included",
"among",
"\"adults\").",
"Then",
"the",
"recommended",
"weighting",
"of",
"\"smokers",
"interviewed\"",
"to",
"match",
"\"smok-",
"ers",
"that",
"exist\"",
"gives",
"the",
"distribution",
"by",
"Time-Zone",
"of",
"the",
"smokers",
"actually",
"interviewed",
"and",
"tabulated",
"(as",
"well",
"as",
"by",
"sex,",
"age,",
"and",
"week",
"within",
"month).",
"These",
"distributions",
"of",
"\"smokers",
"interviewed\"",
"become",
"survey",
"discov-",
"eries",
"within",
"the",
"frame",
"of",
"\"smokers",
"that",
"exist\",",
"itself",
"within",
"the",
"frame",
"of",
"\"all",
"adults\"",
"matched",
"to",
"Census.",
"0951100902"
] |
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0060188666.layout.json
|
[
"A-TEAM",
"THE",
"AMERICAN",
"TOBACCO",
"COMPANY",
"NOVEMBER",
"1994",
"*",
"%%",
"%%",
"FIASHREPORT!",
"****%",
"UNIT",
"SALES",
"SURPASS",
"TOTAL",
"YEAR",
"1993!",
"Last",
"year,",
"we",
"closed",
"out",
"the",
"books",
"realizing",
"a",
"Unit",
"Sales",
"Total",
"of",
"31,120",
"Billion",
"for",
"the",
"year.",
"This",
"year,",
"November",
"14th",
"was",
"a",
"very",
"special",
"day,",
"for",
"we",
"finished",
"the",
"day",
"with",
"a",
"year-to-",
"date",
"sales",
"figure",
"totalling",
"31,275",
"Billion",
"exceeding",
"last",
"vear’s",
"Total",
"Unjt",
"Sales",
"Volume!",
"With",
"a",
"little",
"more",
"than",
"six",
"weeks",
"left",
"in",
"1994,",
"we",
"have",
"an",
"excellent",
"chance",
"of",
"achieving",
"our",
"full",
"year",
"sales",
"goal",
"of",
"36,000",
"Billion",
"units,",
"which",
"will",
"be",
"our",
"best",
"annual",
"performance",
"since",
"1989.",
"Like",
"our",
"President,",
"Don",
"Johnston,",
"|",
"believe",
"that",
"this",
"special",
"milestone",
"event",
"is",
"fully",
"atiributable",
"to",
"our",
"Pride",
"in",
"Performance",
"...",
"American",
"Pride!",
"Again,",
"we",
"thank",
"you",
"all",
"for",
"your",
"determination,",
"your",
"drive",
"and",
"your",
"desire",
"to",
"finish",
"out",
"the",
"year",
"in",
"record",
"fashion",
"for",
"our",
"Company!",
"E.",
"J.",
"Gesell",
"Executive",
"Vice",
"President",
"&",
"Chief",
"Operating",
"Officer"
] |
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518203741_518203796-31.layout.json
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99284103.layout.json
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[
"Ronald",
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"08:28",
"AM",
"To:",
"Sam",
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"co!",
"Steven",
"Watson/Lorillard/MLBA@MLBA,",
"Michael",
"Shannon/Lorillard/MLBA@MLBA,",
"Linda",
"Klemtner/Lorillard/MLBA@MLBA,",
"Kathy",
"SpgrrawlLoriIIard/MLBA@MLBA",
"Subject",
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"\"We",
"Card\"",
"Policy",
"Enforcement",
";_‘?l",
"How",
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"in",
"trying",
"to",
"get",
"information",
"from",
"the",
"46",
"non-reporting",
"states?",
"2018266"
] |
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524860047+-0116-4.layout.json
|
[
"Program",
"and",
"Abstracts",
"GUEST",
"PROGRAM",
"MONDAY,",
"25",
"SEPTEMEER",
"Franklin",
"with",
"Lunch",
"at",
"The",
"Factory",
"9:30a.m.-5:00p.m,",
"Just",
"eighteen",
"miles",
"south",
"of",
"Nashville",
"lies",
"the",
"historic",
"Viclorian",
"town",
"of",
"Franklin.",
"The",
"original",
"19th",
"century",
"downtown",
"is",
"comprised",
"of",
"quaint",
"boutiques,",
"antique",
"shops,",
"art",
"galleries,",
"restaurants,",
"and",
"specialty",
"stores",
"which",
"are",
"housed",
"in",
"the",
"renovated",
"and",
"restored",
"Victotian",
"homes",
"and",
"buildings.",
"The",
"entire",
"area",
"is",
"listed",
"in",
"the",
"National",
"Register",
"of",
"Historic",
"Places.",
"Franklin",
"was",
"a",
"major",
"sitz",
"in",
"the",
"Civil",
"War",
"conflict,",
"To",
"recapture",
"the",
"life",
"and",
"strifc",
"of",
"the",
"Battle",
"of",
"Franklin,",
"we",
"will",
"visit",
"the",
"Carter",
"House.",
"Found",
"just",
"on",
"the",
"edge",
"of",
"town,",
"Carter",
"House",
"was",
"caught",
"in",
"the",
"center",
"of",
"the",
"fierce",
"Rattle",
"of",
"Franklin",
"on",
"November",
"30,",
"1864,",
"It",
"changed",
"hands",
"several",
"times",
"as",
"the",
"battle",
"raged",
"back",
"and",
"fortli",
"between",
"the",
"North",
"and",
"the",
"South.",
"It",
"was",
"finally",
"won",
"by",
"General",
"Hood",
"of",
"Texas",
"at",
"great",
"cost.",
"Built",
"in",
"1830,",
"now",
"it",
"is",
"beautifully",
"restored",
"to",
"its",
"original",
"state",
"and",
"is",
"a",
"Registered",
"National",
"Historic",
"Landmark.",
"A",
"stop",
"for",
"lunch",
"for",
"some",
"regional",
"favorites",
"at",
"Stoveworks,",
"followed",
"by",
"shopping",
"in",
"the",
"charming",
"boutiques",
"and",
"treasure",
"hunting",
"the",
"many",
"antique",
"shops",
"within",
"The",
"Factory",
"at",
"Franklin,",
"enhances",
"this",
"history",
"packed",
"day.",
"TUESDAY,",
"26",
"SEPTEMBER",
"Southern",
"Mansions",
"and",
"Lunch",
"at",
"the",
"Pineapple",
"Room",
"9:00a.m.-3:00p.m.",
"\"T'his",
"tour",
"begins",
"with",
"a",
"drive",
"through",
"historic",
"downtown",
"Nashville.",
"Here",
"you",
"will",
"sec",
"the",
"newly",
"restored",
"Ryman",
"Auditorium,",
"former",
"home",
"of",
"the",
"Grand",
"Ole",
"Opry",
"and",
"Second",
"Avenue,",
"known",
"as",
"“The",
"District,”",
"with",
"its",
"unique",
"shops,",
"restaurants",
"and",
"a",
"multitude",
"of",
"entertainment",
"veniues,",
"Downtown",
"is",
"home",
"to",
"Tootsie’s",
"Orchid",
"Lounge",
"and",
"the",
"Wildhorse",
"Saloon,",
"the",
"country’s",
"premier",
"dance",
"club",
"where",
"The",
"Nashville",
"Network",
"films",
"many",
"star-",
"studded",
"progeams.",
"Further",
"downtown",
"we",
"will",
"get",
"a",
"driving",
"tour",
"of",
"Music",
"Row",
"where",
"all",
"of",
"the",
"“hot",
"licks”",
"are",
"put",
"together",
"in",
"the",
"major",
"recording",
"studios.",
"Next",
"we",
"will",
"drive",
"through",
"Belle",
"Meade,",
"one",
"of",
"the",
"world’s",
"richest",
"and",
"most",
"impressive",
"housing",
"communities,",
"constructed",
"on",
"the",
"lands",
"of",
"the",
"original",
"plantation.",
"Belle",
"Meade",
"Plantation,",
"a",
"Greek",
"Revival",
"mansion,",
"was",
"once",
"the",
"center",
"of",
"a",
"5,400",
"acre",
"plantation,",
"which",
"developed",
"into",
"a",
"world-famous",
"thoroughbred",
"nursery",
"and",
"stud",
"farm.",
"Completed",
"in",
"1853,",
"Belle",
"Meade",
"was",
"the",
"“Queen",
"of",
"Tennessee",
"Plantations”",
"world",
"renowned",
"as",
"a",
"thor-",
"oughbred",
"stud",
"farm",
"and",
"nursery,",
"and",
"was",
"a",
"survivor",
"of",
"the",
"Civil",
"War.",
"Inside",
"the",
"beautifully",
"restored",
"mansion",
"are",
"antique",
"furnishings",
"and",
"decorative",
"arts",
"of",
"the",
"19th",
"century",
"exemplifying",
"the",
"way",
"prosperous",
"Southern",
"plantation",
"owners",
"lived",
"during",
"3",
"52486",
"0051"
] |
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10187145.layout.json
|
[
"~",
"s",
".",
"e",
"e",
"e",
"e",
"i",
"T",
"e",
"e",
"L",
"e",
"oo",
"o",
"Tne",
"Covxcin,",
"For",
"Tusacco",
"Reseanen-U.S",
"AL,",
"Ixc.",
"Septemker",
"4,",
"1879",
"MEMORANDUIAT",
"/",
"‘",
"TO:",
"Drs.",
"Bing,",
"Ford,",
"Hockett,",
"Jacobson,",
"Sommers",
"and",
"Stone",
"FROM:",
"w.",
"U.",
"Gardner",
"SURIECT:",
"Application",
"11501,",
"Simon",
"H.",
"Wender,",
"Ph.D.,",
"University",
"of",
"Oklahoma,",
"Norman.",
"\"In",
"Vivo",
"Studics",
"on",
"the",
"Lffect",
"of",
"(inhaled)",
"Cigarette",
"Smoke",
"Corbhined",
"“with",
"Various",
"'Stress'",
"Conditions",
"on",
"the",
"Activity",
"of",
"Certain",
"lung",
"Enzymes.\"",
"Proposal.",
"Threc",
"'\"protective\"",
"enzyme",
"systems",
"(glutathionc",
"peroxidase",
"[Glut-Px],",
"glutathione",
"reductase",
"[Glut-Rd],",
"and",
"glucose-6-phosphate",
"dehvdrogenase",
"[G6PD])",
"will",
"be",
"determined",
"in",
"rats",
"or",
"mice",
"exposed",
"to",
"single",
"stresses",
"or",
"combinations",
"of,",
"stresses",
"including",
"exposure",
"to",
"cigarette",
"smoke.",
"Usually",
"the",
"additional",
"stresses",
"will",
"be",
"applied",
"to",
"animals",
"that",
"are",
"being",
"exposed",
"to",
"cigarctte",
"smoke.",
"Isozymes",
"of",
"the",
"encymes",
"will",
"also",
"be",
"studied.",
"Consideration",
"will",
"also",
"b",
"giveh",
"to",
"age,",
"nutritional",
"status,",
"timing",
"of",
"stresses",
"and",
"genctic",
"differences.",
"At",
"first",
"the",
"timing",
"of",
"consecutive",
"exposures",
"to",
"stresses",
"will",
"be",
"emphasizud.,",
"The",
"end",
"p01nt<",
"will",
"be",
"the",
"lung,",
"liver",
"and",
"ervthrocyte",
"levels",
"of",
"the",
"encynmes",
"considered",
"to",
"respond",
"to",
"stresses",
"and",
"their",
"isozymes.",
"If",
"time",
"permits,",
"other",
"drugs",
"will",
"be",
"added",
"to",
"the",
"list",
"to",
"be",
"given",
"tc",
"the",
"smoke-exposed",
"animals;",
"for",
"examiic.",
"nitrofurantoin",
"and",
"phenacetin.",
"Also,",
"rats",
"will",
"be",
"given",
"drugs",
"that",
"may",
"correct",
"nutritional",
"deficiencies",
"such",
"as",
"macm'amdc,",
"selenium,",
"vitamin",
"E",
"and",
"combinations",
"of",
"the",
"above.",
"Inhibitors",
"of",
"GEPD",
"such",
"as",
"glucagon",
"will",
"also",
"be",
"given.",
"Theyv",
"state",
"that",
"they",
"are",
"fami.iar",
"with",
"the",
"assavs",
"used",
"for",
"the",
"enzvmeos",
"mentioned",
"and",
"that",
"they",
"comprise",
"a",
"protective",
"mechanism",
"against",
"1ipid",
"neroxidation",
"wvhich",
"might",
"occur",
"under",
"various",
"stress",
"conditions",
"such",
"as",
"ozone",
"exposurc,",
"NO2",
"or",
"CCl4",
"exposures,",
"Thev",
"state",
"that",
"thev",
"have",
"been",
"following",
"the",
"Medlars",
"Il",
"from",
"the",
"N.L.M.",
"for",
"some",
"time",
"to",
"keep",
"up",
"with",
"the",
"publications.",
"They",
"thus",
"have",
"a",
"rather",
"extensive",
"review",
"of",
"factors",
"modifving",
"the",
"enzyme",
"levels",
"and",
"even",
"of",
"the",
"effects",
"of",
"cholorogenic",
"acid",
"which",
"is",
"found",
"in",
"small",
"amounts",
"in",
"tobacco",
"but",
"in",
"larger",
"amounts",
"in",
"coffee.",
"Comment.",
"I",
"find",
"it",
"difficult",
"to",
"rate",
"this",
"proposal.",
"The",
"investigators",
"should",
"be",
"competent",
"to",
"do",
"the",
"chemical",
"testing.",
"Firm",
"protocols",
"for",
"such",
"experiments",
"are-difficult",
"to",
"formulate",
"because",
"in",
"some",
"ways",
"tomorrow's",
"plans",
"denend",
"upon",
"todayv's",
"observations.",
"I",
"cannot",
"he",
"optimistic",
"about",
"how",
"much",
"more",
"we",
"will",
"know",
"when",
"all",
"of",
"the",
"results",
"are",
"in.",
"W.",
"U,",
"Gardner",
"WUG:ek"
] |
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506492377.layout.json
|
[
"INTRODUCTION",
"Many",
"of",
"the",
"major",
"advances",
"in",
"research",
"have",
"depended",
"on",
"studies",
"that",
"have",
"utilized",
"animals",
"as",
"research",
"subjects",
"in",
"one",
"way",
"or",
"another.",
"Many",
"biological",
"and",
"psychological",
"processes",
"can",
"be",
"studied",
"only",
"in",
"intact",
"animal",
"systems.",
"Viewed",
"in",
"this",
"perspective,",
"the",
"use",
"of",
"laboratory",
"animals",
"constitutes",
"a",
"foundation",
"for",
"many",
"other",
"methodologies",
"that",
"are",
"utilized",
"in",
"research.",
"Although",
"the",
"care",
"and",
"use",
"of",
"laboratory",
"animals",
"has",
"not",
"usually",
"been",
"a",
"part",
"of",
"the",
"formal",
"training",
"of",
"graduate",
"students,",
"recent",
"federal",
"policies",
"now",
"make",
"such",
"training",
"important,",
"if",
"not",
"mandatory,",
"for",
"all",
"investigators",
"who",
"plan",
"to",
"use",
"animals",
"for",
"research.",
"The",
"principles",
"and",
"methods",
"that",
"are",
"specific",
"to",
"the",
"use",
"of",
"laboratory",
"animals",
"are",
"aimed",
"at",
"accomplishing",
"two",
"major",
"goals:",
"one,",
"control",
"of",
"the",
"animals’",
"health",
"and",
"environment",
"necessary",
"to",
"assure",
"the",
"validity",
"of",
"scientific",
"results;",
"and,",
"two,",
"compliance",
"with",
"federal",
"regulations",
"reflecting",
"the",
"public",
"concern",
"that",
"animals",
"be",
"treated",
"humanely.",
"The",
"first",
"goal,",
"the",
"validity",
"of",
"scientific",
"results,",
"depends",
"on",
"methodologies",
"that",
"adequately",
"control",
"for",
"animal",
"health",
"and",
"environmental",
"factors.",
"Scientific",
"data",
"are",
"only",
"as",
"\"robust\"",
"or",
"\"healthy\"",
"as",
"the",
"system",
"in",
"which",
"they",
"are",
"collected.",
"The",
"second",
"goal,",
"the",
"humane",
"treatment",
"of",
"animals,",
"addresses",
"the",
"obligation",
"of",
"biomedical",
"research",
"community",
"as",
"a",
"whole",
"to",
"use",
"research",
"animals",
"in",
"an",
"humane",
"and",
"responsible",
"manner.",
"Beyond",
"the",
"moral",
"obligation",
"of",
"researchers,",
"federal",
"regulations",
"mandate",
"that",
"minimum",
"standards",
"be",
"followed",
"to",
"assure",
"the",
"humane",
"care",
"and",
"use",
"of",
"laboratory",
"animals.",
"THE",
"ANIMAL",
"WELFARE",
"ACT",
"A.",
"Historical",
"Perspective",
"The",
"United",
"States",
"Congress",
"passed",
"the",
"first",
"Laboratory",
"Animal",
"Welfare",
"Act",
"in",
"1966,",
"Public",
"Law",
"(P.L.)",
"89-544.",
"The",
"Act,",
"administered",
"by",
"the",
"United",
"States",
"Department",
"of",
"Agriculture",
"(UsDA)",
",",
"established",
"the",
"first",
"legal",
"requirement",
"for",
"research",
"facilities",
"to",
"provide",
"the",
"specified",
"minimum",
"standards",
"of",
"care",
"for",
"research",
"animals",
"and",
"to",
"provide",
"the",
"care",
"of",
"an",
"attending",
"veterinarian.",
"1In",
"1970,",
"the",
"Act",
"was",
"amended",
"(P.L.",
"91-579)",
"and",
"renamed",
"\"The",
"Animal",
"Welfare",
"Act\".",
"The",
"scope",
"of",
"the",
"law",
"was",
"broadened",
"to",
"include",
"protection",
"for",
"additional",
"animal",
"species",
"and",
"to",
"require",
"research",
"facilities",
"to",
"register",
"with",
"the",
"USDA",
"and",
"provide",
"an",
"annual",
"report",
"of",
"animal",
"utilization",
"and",
"assurances",
"of",
"compliance",
"with",
"the",
"standards",
"for",
"care.",
"The",
"Act",
"was",
"again",
"amended",
"in",
"1976",
"by",
"P.L.",
"94-279",
"to",
"include",
"more",
"stringent",
"standards",
"for",
"transportation",
"of",
"animals.",
"Each",
"time",
"the",
"Animal",
"Welfare",
"Act",
"is",
"amended,",
"the",
"relevant",
"federal",
"regulations",
"are",
"also",
"rewritten",
"to",
"include",
"the",
"new",
"provisions",
"of",
"the",
"law.",
"The",
"detailed",
"rules",
"and",
"regulations",
"for",
"the",
"Animal",
"Welfare",
"Act",
"are",
"published",
"in",
"the",
"Code",
"of",
"Federal",
"Regulations",
"(CFR),",
"Title",
"9,",
"Chapter",
"A,",
"Parts",
"1,",
"2",
"and",
"3.",
"These",
"regulatlons",
"are",
"the",
"guidelines",
"that",
"must",
"be",
"followed",
"to",
"assure",
"compliance",
"with",
"the",
"\"intent\"",
"of",
"the",
"law.",
"_",
"LLE2",
"61308",
"RJR-US",
"v.",
"PM,",
"ET",
"AL."
] |
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2057719276.layout.json
|
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88680417_0418-0.layout.json
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"of",
"marking",
"will",
"4LIb0898S",
"hr"
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500603267+-3283-10.layout.json
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"20th",
".",
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"A.C.",
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"University",
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770,
1653,
786
],
[
1668,
770,
1686,
786
],
[
1703,
771,
1799,
790
],
[
1813,
773,
1902,
788
],
[
1919,
778,
1928,
788
],
[
1945,
773,
2043,
789
],
[
2059,
774,
2128,
790
],
[
1575,
800,
1623,
819
],
[
1642,
801,
1716,
816
],
[
1734,
801,
1753,
817
],
[
1772,
802,
1863,
818
],
[
1882,
802,
2003,
822
],
[
2023,
802,
2127,
819
],
[
1575,
830,
1626,
849
],
[
1639,
831,
1698,
852
],
[
1713,
831,
1792,
851
],
[
1806,
832,
1872,
852
],
[
1352,
879,
1371,
895
],
[
1384,
880,
1471,
898
],
[
1576,
881,
1652,
897
],
[
1669,
881,
1688,
898
],
[
1706,
882,
1805,
898
],
[
1823,
888,
1833,
898
],
[
1852,
883,
1939,
903
],
[
1957,
884,
2067,
904
],
[
2087,
885,
2128,
901
],
[
1575,
911,
1645,
927
],
[
1658,
912,
1708,
931
],
[
1722,
912,
1783,
929
],
[
1797,
913,
1854,
929
],
[
1866,
913,
1934,
933
],
[
1353,
962,
1398,
976
],
[
1410,
962,
1471,
979
],
[
1575,
964,
1687,
984
],
[
1703,
966,
1738,
980
],
[
1756,
966,
1887,
988
],
[
1904,
967,
2031,
986
],
[
2048,
968,
2127,
987
],
[
1575,
994,
1657,
1013
],
[
1672,
995,
1750,
1011
],
[
1767,
996,
1829,
1016
],
[
1353,
1043,
1409,
1058
],
[
1416,
1043,
1569,
1061
],
[
1576,
1044,
1654,
1065
],
[
1666,
1046,
1789,
1065
],
[
1802,
1046,
1869,
1063
],
[
1882,
1052,
1917,
1063
],
[
1931,
1048,
2128,
1067
],
[
1575,
1074,
1613,
1090
],
[
1627,
1075,
1752,
1090
],
[
1765,
1076,
1835,
1092
],
[
1848,
1077,
1939,
1093
],
[
1954,
1078,
2069,
1093
],
[
2083,
1079,
2126,
1098
],
[
1575,
1105,
1707,
1125
],
[
1353,
1152,
1413,
1167
],
[
1425,
1152,
1558,
1171
],
[
1576,
1154,
1685,
1175
],
[
1703,
1156,
1767,
1173
],
[
1785,
1157,
1859,
1176
],
[
1878,
1157,
1962,
1173
],
[
1979,
1158,
1998,
1173
],
[
2013,
1158,
2129,
1174
],
[
1575,
1185,
1616,
1200
],
[
1632,
1185,
1726,
1204
],
[
1742,
1186,
1803,
1202
],
[
1820,
1187,
1886,
1202
],
[
1901,
1188,
2037,
1206
],
[
2052,
1189,
2127,
1204
],
[
1577,
1214,
1711,
1235
],
[
1352,
1262,
1371,
1277
],
[
1384,
1263,
1524,
1281
],
[
1577,
1264,
1654,
1281
],
[
1668,
1265,
1688,
1281
],
[
1705,
1266,
1804,
1281
],
[
1820,
1272,
1830,
1282
],
[
1848,
1266,
1934,
1285
],
[
1951,
1267,
2061,
1287
],
[
2080,
1267,
2127,
1283
],
[
1576,
1294,
1629,
1310
],
[
1642,
1295,
1661,
1310
],
[
1674,
1295,
1762,
1311
],
[
1776,
1296,
1805,
1311
],
[
1818,
1296,
1893,
1315
],
[
1907,
1296,
2011,
1312
],
[
2024,
1297,
2074,
1316
],
[
2087,
1298,
2127,
1313
],
[
1576,
1324,
1601,
1340
],
[
1618,
1325,
1696,
1344
],
[
1712,
1325,
1782,
1345
],
[
1354,
1373,
1371,
1387
],
[
1384,
1373,
1523,
1391
],
[
1576,
1375,
1688,
1395
],
[
1700,
1375,
1721,
1391
],
[
1733,
1376,
1840,
1395
],
[
1853,
1376,
1939,
1392
],
[
1952,
1376,
2021,
1392
],
[
2034,
1377,
2127,
1393
],
[
1577,
1405,
1668,
1420
],
[
1687,
1406,
1769,
1424
],
[
1354,
1451,
1371,
1465
],
[
1384,
1451,
1479,
1469
],
[
1578,
1453,
1695,
1471
],
[
1719,
1452,
1858,
1472
],
[
1881,
1454,
1984,
1472
],
[
2010,
1454,
2128,
1471
],
[
1578,
1482,
1668,
1503
],
[
2107,
1566,
2129,
1579
],
[
2160,
852,
2182,
882
]
] |
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