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from pathlib import Path

import numpy as np
import pandas as pd
import torch
import torch.nn as nn
from torch.utils.data import DataLoader
from sklearn.metrics import average_precision_score

from ..atlas.dataset import PairDataset
from ..atlas.model_mlp import AtlasMLP
from ..utils.io import load_cfg, set_seed, save_json



def _train_model(ds: PairDataset, lr: float, epochs: int, batch_size: int,
                 device: str) -> AtlasMLP:
    model = AtlasMLP().to(device).train()
    optimizer = torch.optim.AdamW(model.parameters(), lr=lr)
    loader = DataLoader(ds, batch_size=batch_size, shuffle=True)
    for _ in range(epochs):
        for p, l, y, _, _ in loader:
            p, l, y = p.to(device), l.to(device), y.squeeze(-1).to(device)
            loss = nn.functional.binary_cross_entropy_with_logits(model(p, l), y)
            optimizer.zero_grad(); loss.backward(); optimizer.step()
    return model.eval()


@torch.no_grad()
def _predict_proba(model: AtlasMLP, ds: PairDataset, batch_size: int,
                   device: str) -> np.ndarray:
    loader = DataLoader(ds, batch_size=batch_size, shuffle=False)
    probs = []
    for p, l, _, _, _ in loader:
        probs.append(torch.sigmoid(model(p.to(device), l.to(device))).cpu().numpy())
    return np.concatenate(probs)


def _scores_uncertainty(model, pool_ds, batch_size, device):
    """Predictive entropy: max at p=0.5."""
    p = _predict_proba(model, pool_ds, batch_size, device)
    entropy = -p * np.log(p + 1e-9) - (1 - p) * np.log(1 - p + 1e-9)
    return entropy


def _scores_diversity(model, pool_ds, labeled_ds, batch_size, device):
    """
    Mean embedding distance from pool point to nearest labeled point.
    Uses concatenated (protein, ligand) embeddings as feature space.
    """
    def _embeddings(ds):
        embs = []
        for p, l, _, _, _ in DataLoader(ds, batch_size=batch_size):
            embs.append(torch.cat([p, l], dim=-1).numpy())
        return np.concatenate(embs)

    pool_emb    = _embeddings(pool_ds)
    labeled_emb = _embeddings(labeled_ds)

    pool_n    = pool_emb    / (np.linalg.norm(pool_emb,    axis=1, keepdims=True) + 1e-9)
    labeled_n = labeled_emb / (np.linalg.norm(labeled_emb, axis=1, keepdims=True) + 1e-9)
    sims = pool_n @ labeled_n.T         
    return 1.0 - sims.max(axis=1)       


def _scores_causal(pool_ds, causal_effects: dict) -> np.ndarray:
    """
    Causal weight: prioritize pairs from high-ATE transporters.
    causal_effects : {gene_name: ATE_value}  (positive = protective)
    """
    weights = np.zeros(len(pool_ds.pairs))
    for i, (ti, _ci, _y) in enumerate(pool_ds.pairs):
        gene = pool_ds.Tnames[ti] if hasattr(pool_ds, "Tnames") else str(ti)
        weights[i] = abs(causal_effects.get(gene, 0.0))
    return weights / (weights.max() + 1e-9)



def run_active_learning(
    cfg_path: str = "env/config.yaml",
    strategy: str = "uncertainty",          
    causal_csv: str = "results/causal_effects.csv",
) -> dict:
    """
    Run a pool-based active learning simulation.

    Returns a dict with AUPRC at each round for the chosen strategy.
    """
    cfg = load_cfg(cfg_path)
    set_seed(cfg["training"]["seed"])

    device = "cuda" if torch.cuda.is_available() else "cpu"
    proc   = Path(cfg["paths"]["processed"])
    res    = Path(cfg["paths"]["results"])
    res.mkdir(parents=True, exist_ok=True)

    al_cfg   = cfg["active_learning"]
    tr_cfg   = cfg["training"]
    full_ds  = PairDataset(proc)
    n        = len(full_ds.pairs)
    rng      = np.random.default_rng(tr_cfg["seed"])

    causal_effects = {}
    if strategy in ("causal", "hybrid") and Path(causal_csv).exists():
        df_c = pd.read_csv(causal_csv)
        causal_effects = dict(zip(df_c["gene"], df_c["ATE"].abs()))

    init_k    = int(al_cfg["init_frac"] * n)
    acquire_k = int(al_cfg["acquire_per_iter"] * n)
    labeled   = set(rng.choice(n, size=init_k, replace=False).tolist())
    pool      = set(range(n)) - labeled

    curve_fracs, curve_auprc = [], []

    for it in range(al_cfg["iters"]):
        labeled_list = sorted(labeled)
        pool_list    = sorted(pool)

        ds_labeled = PairDataset(proc, labeled_list)
        ds_pool    = PairDataset(proc, pool_list)

        model = _train_model(ds_labeled, tr_cfg["lr"], epochs=8,
                             batch_size=tr_cfg["batch_size"], device=device)

        if strategy == "random":
            scores = rng.random(len(pool_list))
        elif strategy == "uncertainty":
            scores = _scores_uncertainty(model, ds_pool, tr_cfg["batch_size"], device)
        elif strategy == "diversity":
            scores = _scores_diversity(model, ds_pool, ds_labeled, tr_cfg["batch_size"], device)
        elif strategy == "causal":
            scores = _scores_causal(ds_pool, causal_effects)
        elif strategy == "hybrid":
            s_unc    = _scores_uncertainty(model, ds_pool, tr_cfg["batch_size"], device)
            s_causal = _scores_causal(ds_pool, causal_effects)
            scores   = 0.5 * s_unc / (s_unc.max() + 1e-9) + 0.5 * s_causal
        else:
            raise ValueError(f"Unknown strategy: {strategy!r}")

        acquire_k_actual = min(acquire_k, len(pool_list))
        top_local = np.argsort(scores)[::-1][:acquire_k_actual]
        newly_labeled = {pool_list[i] for i in top_local}
        labeled |= newly_labeled
        pool    -= newly_labeled

        hold_size = min(int(0.2 * n), len(pool))
        if hold_size > 0:
            hold_idx = rng.choice(sorted(pool), size=hold_size, replace=False)
            ds_hold  = PairDataset(proc, hold_idx.tolist())
            probs    = _predict_proba(model, ds_hold, tr_cfg["batch_size"] * 2, device)
            y_hold   = np.array([y for _, _, y in ds_hold.pairs])
            ap       = float(average_precision_score(y_hold, probs))
        else:
            ap = float("nan")

        frac = len(labeled) / n
        curve_fracs.append(frac)
        curve_auprc.append(ap)
        print(f"  iter={it+1}  labeled={len(labeled)}/{n} ({frac:.2%})  AUPRC={ap:.4f}")

    snapshot = {
        "strategy": strategy,
        "curves": {"fracs": curve_fracs, "auprc": curve_auprc},
    }
    save_json(snapshot, res / f"al_section4_{strategy}_snapshot.json")
    return snapshot