Datasets:
Expand GenomeQA dataset card
Browse filesDocument benchmark purpose, provenance, task families, configuration meanings, schema, usage, balanced subsets, and citation.
README.md
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dataset_info:
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- config_name: binary
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features:
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path: mcq_600/train-*
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#
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The
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[`scripts/create_600_subsets.py`](scripts/create_600_subsets.py) for the reproducible generation script.
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---
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pretty_name: GenomeQA
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language:
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- en
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task_categories:
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- question-answering
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tags:
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- biology
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- bioinformatics
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- genomics
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- dna
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- benchmark
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- multiple-choice
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dataset_info:
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- config_name: binary
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features:
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path: mcq_600/train-*
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---
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# GenomeQA
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GenomeQA is a diagnostic question-answering benchmark for evaluating whether general-purpose language models can
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reason directly over raw nucleotide sequences. It presents English questions containing one or more DNA sequences and
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asks the model to select an answer using biological signals such as sequence composition, motifs, and motif context.
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It does not assume a specialized DNA encoder or task-specific model training.
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The original benchmark contains 5,200 examples—2,600 binary-choice questions and 2,600 four-option multiple-choice
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questions—with sequence lengths from 6 to 1,000 base pairs. It covers six task families:
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1. enhancer and promoter identification;
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2. splice-site identification;
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3. taxonomic classification;
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4. histone-mark and chromatin-state prediction;
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5. transcription-factor binding-site prediction; and
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6. transcription-factor motif prediction.
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## Source and construction
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This repository packages the data introduced in
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[GenomeQA: Benchmarking General Large Language Models for Genome Sequence Understanding](https://huggingface.co/papers/2604.05774)
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by Weicai Long, Yusen Hou, Junning Feng, Houcheng Su, Shuo Yang, Donglin Xie, and Yanlin Zhang.
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The paper constructs GenomeQA from established genomic resources:
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| Task family | Primary source | Sequence length |
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| --- | --- | ---: |
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| Enhancer and promoter identification | EPDnew and ENCODE SCREEN | 400 bp |
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| Splice-site identification | Nucleotide Transformer downstream tasks | 600 bp |
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| Taxonomic classification | NCBI RefSeq | 1,000 bp |
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| Histone-mark prediction | Nucleotide Transformer downstream tasks | 1,000 bp |
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| TFBS prediction | ENCODE and JASPAR | 100 bp |
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| TF motif prediction | ENCODE and JASPAR | 6–20 bp |
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The authors standardize sequence windows, remove overlapping examples to reduce ambiguity, exclude sequences with
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ambiguous nucleotide bases, and convert the resulting annotations into binary-choice and multiple-choice question
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templates. Refer to the paper for the full construction procedure and source-database citations.
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## Configurations
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All configurations contain a single `train` split. The full benchmark configurations are intentionally not equal in
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size across subtasks: each contains 500 examples for the first five task families and 100 motif examples. Benchmark
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results should therefore report per-subtask accuracy and use an unweighted mean across the six subtasks when a single
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headline score is needed.
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| Configuration | Rows | Meaning |
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| --- | ---: | --- |
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| `binary` | 2,600 | Full benchmark in binary-choice format, with two ordered options per question. |
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| `mcq` | 2,600 | Full benchmark in four-option multiple-choice format. |
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| `binary_600` | 600 | Lower-cost binary subset with 100 examples from each of the six subtasks. |
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| `mcq_600` | 600 | Lower-cost MCQ subset with 100 examples from each of the six subtasks. |
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| `eukaryote_cls` | 1,000 | Auxiliary four-option eukaryotic taxonomy set stored separately from the original 5,200-example benchmark. |
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The `binary_600` and `mcq_600` configurations were sampled without replacement using seed 42 from source revision
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`a71ab7e0e72b8eca7acd4475744dccd0159b20be`. The 100 selected examples from each subtask were then combined and
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shuffled so the rows are not stored in subtask blocks. These subsets are balanced by task family, but not necessarily
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by every internal label or question dimension. See
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[`scripts/create_600_subsets.py`](scripts/create_600_subsets.py) for the reproducible generation script.
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## Data fields
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| Field | Description |
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| --- | --- |
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| `id` | Integer identifier within the source subtask. |
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| `subtask` | Task-family identifier used for grouped evaluation. |
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| `question` | Natural-language question containing the relevant DNA sequence or sequences. |
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| `options` | Ordered list of candidate answers. |
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| `answer_index` | Zero-based index of the correct entry in `options`. |
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| `answer_text` | Correct answer text. For sequence-selection questions, this may itself be a DNA sequence. |
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| `metadata` | Serialized task-specific metadata describing the question dimension and source label. |
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## Usage
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```python
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from datasets import load_dataset
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binary = load_dataset("HuggingFaceBio/genomeqa", "binary", split="train")
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representative_mcq = load_dataset("HuggingFaceBio/genomeqa", "mcq_600", split="train")
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```
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## Citation
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```bibtex
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@article{long2026genomeqa,
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title={GenomeQA: Benchmarking General Large Language Models for Genome Sequence Understanding},
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author={Long, Weicai and Hou, Yusen and Feng, Junning and Su, Houcheng and Yang, Shuo and Xie, Donglin and Zhang, Yanlin},
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journal={arXiv preprint arXiv:2604.05774},
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year={2026}
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}
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```
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