Datasets:
fix dataset_info: add script_version to all three configs
Browse files
README.md
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@@ -25,6 +25,8 @@ dataset_info:
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features:
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- name: benchmark_id
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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features:
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- name: benchmark_id
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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@@ -193,6 +197,8 @@ dataset_info:
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features:
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- name: benchmark_id
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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@@ -269,7 +275,7 @@ dataset_info:
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dataset_size: 334784354
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---
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# Perturbation Bench
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A benchmark of **sequence-level perturbation tasks** for evaluating DNA foundation models.
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Each task presents pairs of genomic sequences — one real (unperturbed) and one structurally
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### `syn_human` · `syn_mouse` — Synonymous codon substitution (20,000 pairs each)
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Codons within a real CDS are replaced with the highest-frequency synonym for the target
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species, while the upstream and
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downstream flanking sequence is left unchanged. Amino acid identity is preserved by
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construction. The model should prefer the natural codon usage over the artificially
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optimised variant.
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@@ -298,20 +304,15 @@ optimised variant.
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### `motif_human` — CAG repeat insertion (20,000 pairs)
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A 30 bp
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-
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original and perturbed.
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- Annotations: GENCODE v45 / GRCh38;
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- Window layout:
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patch always at positions 8,162–8,192 (`patch_start_in_seq`–`patch_end_in_seq`).
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For exons with phase 1 or 2, the 1–2 split-codon bases from the preceding exon are
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placed immediately before position 8,102, so the upstream genomic context is
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8,102 bp (phase 0), 8,101 bp (phase 1), or 8,100 bp (phase 2).
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---
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@@ -340,17 +341,17 @@ from datasets import load_dataset
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# Synonymous codon substitution — human
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syn_human = load_dataset(
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"HuggingFaceBio/perturbation-bench", "syn_human", split="test"
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)
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# Synonymous codon substitution — mouse
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syn_mouse = load_dataset(
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"HuggingFaceBio/perturbation-bench", "syn_mouse", split="test"
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)
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# CAG motif insertion
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motif = load_dataset(
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"HuggingFaceBio/perturbation-bench", "motif_human", split="test"
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)
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```
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features:
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- name: benchmark_id
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dtype: string
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- name: script_version
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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features:
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- name: benchmark_id
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dtype: string
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- name: script_version
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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features:
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- name: benchmark_id
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dtype: string
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- name: script_version
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dtype: string
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- name: annotation_source
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dtype: string
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- name: genome_assembly
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dataset_size: 334784354
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---
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# Carbon Perturbation Bench
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A benchmark of **sequence-level perturbation tasks** for evaluating DNA foundation models.
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Each task presents pairs of genomic sequences — one real (unperturbed) and one structurally
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### `syn_human` · `syn_mouse` — Synonymous codon substitution (20,000 pairs each)
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Codons within a real CDS are replaced with the highest-frequency synonym for the target
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species (`recoding_mode = "optimize"`, `optimization_rate = 1.0`), while the upstream and
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downstream flanking sequence is left unchanged. Amino acid identity is preserved by
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construction. The model should prefer the natural codon usage over the artificially
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optimised variant.
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### `motif_human` — CAG repeat insertion (20,000 pairs)
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A 30 bp region starting 60 bp downstream of the CDS start is replaced with 10 consecutive
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CAG triplets (`CAGCAGCAGCAGCAGCAGCAGCAGCAGCAG`),
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mimicking the pathological trinucleotide repeat expansions underlying polyglutamine
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disorders (Huntington's disease, SCAs, DRPLA). The substitution is length-preserving
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(30 bp in, 30 bp out), so the total window remains 8,192 bp. All sequence outside the
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patch is identical between original and perturbed.
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- Annotations: GENCODE v45 / GRCh38; 9,705 unique genes.
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- Window layout: 8,102 bp upstream flank, CDS start at position 8,102, patch at positions 8,162–8,192.
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---
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# Synonymous codon substitution — human
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syn_human = load_dataset(
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"HuggingFaceBio/carbon-perturbation-bench", "syn_human", split="test"
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)
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# Synonymous codon substitution — mouse
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syn_mouse = load_dataset(
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"HuggingFaceBio/carbon-perturbation-bench", "syn_mouse", split="test"
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)
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# CAG motif insertion
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motif = load_dataset(
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"HuggingFaceBio/carbon-perturbation-bench", "motif_human", split="test"
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)
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```
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