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medium_divergent_branch_00444 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.478 and an adjusted p-value of 0.04589. Which protein is encoded by the gene associated with this specific statistical evidence? | Zinc finger protein 608 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_00445 | FHL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We used a yeast two-hybrid system and identified a novel FHL1-binding protein.' Which protein, connected to FHL1 via an interaction, is the subject of this specific evidence? | Nuclear receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FHL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We used a yeast two-hybrid system and identified a novel FH... | |
medium_divergent_branch_00446 | MED25 interacts with multiple genes. One of these interaction partners was isolated and shown to associate with retinoic acid (RA)-bound retinoic acid receptor (RAR) through the C-terminal nuclear hormone receptor (NR) box/LxxLL motif, thereby increasing RAR/RXR-mediated transcription. Which disease is associated with ... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MED25 interacts with multiple genes. One of these interaction partners was isolated and shown to associate with retinoic acid (RA)-bound retinoic aci... | |
medium_divergent_branch_00447 | RALBP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that RLIP/RalBP1 interacts with an active p34cdc2.cyclinB1 (cdk1) enzyme and that this interaction is crucial for the mitotic phosphorylation of Epsin that, once phosphorylated, is no longer competent for e... | G2/mitotic-specific cyclin-B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RALBP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show here that RLIP/RalBP1 interacts with an ... | |
medium_divergent_branch_00448 | FBXL14 interacts with multiple proteins. One specific interaction partner is described as being ubiquitinated and targeted for proteasomal degradation by FBXL14, a process that suppresses the partner's protein stability and prevents the activation of target genes involved in breast cancer metastasis. Which protein, enc... | CUB domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL14 interacts with multiple proteins. One specific interaction partner is described as being ubiquitinated and targeted for proteasomal degradatio... | |
medium_divergent_branch_00450 | The FLII gene interacts with multiple proteins. One interaction involves a protein described as an actin-related component of the SWI/SNF complex, specifically BAF53, to which Fli-I binds directly. Which protein is encoded by the gene corresponding to this specific interacting partner? | Actin-like protein 6A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00450","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FLII gene interacts with multiple proteins. One interaction involves a protein described as an actin-related component of the SWI/SNF complex, sp... | |
medium_divergent_branch_00452 | HLA-C interacts with multiple proteins. One interaction is characterized by evidence stating: 'Using soluble, recombinant [protein] molecules and NK inhibitory receptors (NKIR, members of the immunoglobulin superfamily), we show that [protein] binds to NKIR molecules with extremely fast association and dissociation rat... | immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00452","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-C interacts with multiple proteins. One interaction is characterized by evidence stating: 'Using soluble, recombinant [protein] molecules and NK ... | |
medium_divergent_branch_00453 | BAZ1A interacts with multiple genes. One specific interaction is supported by evidence stating: 'Direct interaction of the CHRAC-15/17 complex with the ACF1 subunit is essential for this process.' Which disease is associated with the gene involved in this specific interaction via genomic alterations? | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00453","source_qa_id":"medium_divergent_branch_07380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BAZ1A interacts with multiple genes. One specific interaction is supported by evidence stating: '... | |
medium_divergent_branch_00454 | The gene SLC22A3 (encoding organic cation transporter 3, OCT3) is associated with multiple molecular functions. One specific function is supported by evidence stating: 'The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., ... | monoamine transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00454","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC22A3 (encoding organic cation transporter 3, OCT3) is associated with multiple molecular functions. One specific function is supported by... | |
medium_divergent_branch_00456 | ADAP1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'All groups of PKC associate directly through their cysteine rich domains.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein kinase C zeta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAP1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'All groups of PKC associate directly... | |
medium_divergent_branch_00457 | Allopurinol interacts with multiple drugs. One of these interacting drugs exhibits a pharmacokinetic profile where treatment with either allopurinol or chlorpromazine significantly increases its half-life (P < 0.001 in both cases). Which disease is the drug exhibiting this specific half-life increase indicated for? | retinoblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Allopurinol interacts with multiple drugs. One of these interacting drugs exhibits a pharmacokinetic profile where treatment with either allopurinol ... | |
medium_divergent_branch_00458 | USP7 interacts with multiple proteins. One of these interactions is characterized by the mechanism: 'Mechanistically, the interacting partner bound to USP7 to prevent ubiquitination-mediated degradation of β-Catenin.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | WD repeat-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00458","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP7 interacts with multiple proteins. One of these interactions is characterized by the mechanism: 'Mechanistically, the interacting partner bound t... | |
medium_divergent_branch_00459 | PTF1A is associated with multiple biological processes. One specific association is supported by evidence stating: 'The essential role of PTF1A in normal cerebellar development was confirmed by detailed neuropathological analysis of Ptf1a(-/-) mice.' Which anatomical structure is the result of the development process l... | cerebellum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTF1A is associated with multiple biological processes. One specific association is supported by evidence stating: 'The essential role of PTF1A in no... | |
medium_divergent_branch_00460 | CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we demonstrate that in 293T cells, Flag-tagged Ctf18 forms a seven-subunit cohesion-RFC complex comprised of Ctf18, Dcc1, Ctf8, RFCp40, RFCp38, RFCp37, and RFCp36 (Ctf18-RFC).' Which protein, connected to CHTF18 v... | Replication factor C subunit 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00460","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we demonstrate that in 293T cells, Flag-ta... | |
medium_divergent_branch_00461 | PSMA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Identify the disease associated with the protein described ... | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_divergent_branch_00462 | PTPN21 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro and in vivo binding studies demonstrated that PTPD1 can interact with a specific tyrosine kinase and that residues 726-848 of PTPD1 are essential for this interaction.' Note that PTPD1 is an alias for PTPN21. Which prot... | Cytoplasmic tyrosine-protein kinase BMX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00462","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN21 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro and in vivo binding studies demonstrated that PT... | |
medium_divergent_branch_00463 | Acyclovir interacts with multiple drugs. One of these interacting agents has been shown to reduce the efflux of antiviral drugs from the central nervous system. Which disease is the drug exhibiting this specific pharmacokinetic effect indicated for? | gout | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00463","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Acyclovir interacts with multiple drugs. One of these interacting agents has been shown to reduce the efflux of antiviral drugs from the central nerv... | |
medium_divergent_branch_00464 | MAPK14 is associated with multiple biological processes. One association is supported by evidence stating: 'These results show that p38 MAP kinase plays a role in SM-induced cytokine production in HEK and suggest that inhibiting this pathway may alleviate the profound inflammatory response elicited by cutaneous SM expo... | regulation of cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK14 is associated with multiple biological processes. One association is supported by evidence stating: 'These results show that p38 MAP kinase pl... | |
medium_divergent_branch_00465 | ABCA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results suggest a potential role for ABCA2 in macrophage lipid metabolism and neural development.' Which biological process, connected to the process implied by this evidence via an 'is a' relationship, is the... | primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results suggest a potential role for A... | |
medium_divergent_branch_00467 | PLCG1 interacts with multiple genes. One of these interaction partners is a p21Ras-specific guanine nucleotide exchange factor that directly binds to the SH3 domain of PLC-gamma1. Which disease is associated with this specific gene via a biomarker relationship? | colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00467","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCG1 interacts with multiple genes. One of these interaction partners is a p21Ras-specific guanine nucleotide exchange factor that directly binds to... | |
medium_divergent_branch_00468 | NUTF2 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'Both the FG-repeat domain of nucleoporin CAN/Nup214 and a novel human 15 kDa protein (p15) with homology to NTF2 (a nuclear transport factor which associates with RanGDP), directly bind to the interacting part... | mRNA export from nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00468","source_qa_id":"medium_divergent_branch_01455","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NUTF2 is reported to interact with multiple genes. One specific interaction is supported by evide... | |
medium_divergent_branch_00469 | CDH5 (VE-cadherin) interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a mutant VE-cadherin lacking a highly conserved octapeptide, we demonstrated that it is required for the binding of a specific catenin protein to VE-cadherin as determined by immunoprecipitation and colocalizat... | Catenin delta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00469","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDH5 (VE-cadherin) interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a mutant VE-cadherin lacking a highly c... | |
medium_divergent_branch_00470 | The gene PFKP interacts with multiple other genes. One of these interacting partners is described by the following evidence: 'Phosphorylated PFKP binds to the N-terminal SH2 domain of the regulatory subunit of PI3K, which is distinct from binding of Gab1 to the C-terminal SH2 domain of the regulatory subunit of PI3K, a... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PFKP interacts with multiple other genes. One of these interacting partners is described by the following evidence: 'Phosphorylated PFKP bin... | |
medium_divergent_branch_00471 | SRSF1 interacts with multiple genes. One of these interacting partners is supported by evidence showing that recombinant forms of the partner protein bound to and phosphorylated GST-SF2/ASF in vitro. Which disease is associated with this specific interacting gene? | autism spectrum disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRSF1 interacts with multiple genes. One of these interacting partners is supported by evidence showing that recombinant forms of the partner protein... | |
medium_divergent_branch_00472 | HCN4 interacts with multiple proteins. One of these interaction partners has been experimentally shown to coimmunoprecipitate with HCN4 from membrane fraction proteins. Which protein is encoded by the gene corresponding to this specific interaction partner? | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00472","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCN4 interacts with multiple proteins. One of these interaction partners has been experimentally shown to coimmunoprecipitate with HCN4 from membrane... | |
medium_divergent_branch_00473 | IRF2BP2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have identified two novel proteins that interact specifically with the C-terminal repression domain of a transcription factor.' Which disease is associated with the gene described in this evidence via genomic alteratio... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00473","source_qa_id":"medium_divergent_branch_00195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"IRF2BP2 interacts with multiple genes. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_00474 | ING4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that natively regulated association of the ING4/5 PHD domain with HBO1-JADE determines the growth inhibitory function of the complex, linked to its tumor suppressor activity.' Which protein, connected to ING4 via this inte... | Protein Jade-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that natively regulated association of the ING4/5 P... | |
medium_divergent_branch_00475 | The protein IL17RB is involved in multiple biological processes. One specific process is characterized by the evidence statement: 'Like IL-25, this activity is dependent on the IL-17RA and IL-17RB receptor subunits.' Identify the biological process that is positively regulated by this specific IL17RB-associated process... | interleukin-5 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein IL17RB is involved in multiple biological processes. One specific process is characterized by the evidence statement: 'Like IL-25, this a... | |
medium_divergent_branch_00476 | FYB1 is known to interact with multiple proteins. One specific interaction involves an intracellular protein of unknown identity that associates directly with p59fyn(T) within the receptor complex. Which protein is encoded by the gene corresponding to this interacting partner? | Tyrosine-protein kinase Fyn | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00476","source_qa_id":"medium_divergent_branch_00109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FYB1 is known to interact with multiple proteins. One specific interaction involves an intracellu... | |
medium_divergent_branch_00477 | COL4A1 is associated with multiple biological processes. One association is supported by clinical evidence describing common systemic signs such as arterial retinal tortuosity, muscle cramps, small vessel brain disease, Raynaud phenomena, and kidney defects. Which anatomical structure is the result of the morphogenesis... | retina blood vessel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00477","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL4A1 is associated with multiple biological processes. One association is supported by clinical evidence describing common systemic signs such as a... | |
medium_divergent_branch_00478 | GPS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In order to gain a better understanding of the mechanistic basis underlying the roles of these two human MutS proteins, we have identified G-protein pathway suppressor 2 (GPS2) (i.e., an integral component of a deacetylase complex... | MutS protein homolog 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In order to gain a better understanding of the mechanistic ... | |
medium_divergent_branch_00479 | RPS3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast-two hybrid screen, we identified a small ubiquitin-related modifier as a new interacting partner of RPS3.' Which disease is causally linked to the gene identified in this specific evidence? | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00479","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPS3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast-two hybrid screen, we identified a small ubiquit... | |
medium_divergent_branch_00480 | NCOA1 interacts with multiple proteins. One specific interaction is supported by evidence showing that CFP fusions to a retinoic acid receptor or its ligand-binding domain exhibited rapid ligand-dependent FRET to YFP-tagged nuclear receptor interaction domains of the coactivators SRC-1 and PBP. Which protein product is... | Retinoic acid receptor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00480","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA1 interacts with multiple proteins. One specific interaction is supported by evidence showing that CFP fusions to a retinoic acid receptor or its... | |
medium_divergent_branch_00481 | NCOA6 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that it strongly interacts with activating signal cointegrator (ASC)-2 and weakly with cyclic adenosine monophosphate responsive element binding protein (CBP) in in vitro glutathione S-transferase (G... | ovarian cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA6 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that it strongly interacts w... | |
medium_divergent_branch_00482 | BACE2 is associated with multiple biological processes. One association is supported by evidence showing that mice with functionally inactive Bace2, as well as insulin-resistant mice treated with a newly identified Bace2 inhibitor, exhibit augmented β cell mass and improved control of a specific metabolic state due to ... | carbohydrate homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BACE2 is associated with multiple biological processes. One association is supported by evidence showing that mice with functionally inactive Bace2, ... | |
medium_divergent_branch_00483 | ITGB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies revealed different patterns of association between the four TM4SF studied and beta1 integrin.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | CD151 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00483","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies revealed different patterns... | |
medium_divergent_branch_00484 | NKX2-5 is involved in multiple biological processes. One specific process is supported by evidence stating that overexpression of a dominant-negative mutant of Csx/Nkx2-5 induced apoptosis in cultured cardiomyocytes, whereas expression of the wild-type protein protected cardiomyocytes from doxorubicin-induced apoptotic... | cardiac muscle cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX2-5 is involved in multiple biological processes. One specific process is supported by evidence stating that overexpression of a dominant-negative... | |
medium_divergent_branch_00487 | The protein PLCZ1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by the evidence: 'All PLCZ1 proteins including fish could induce Ca(2+) oscillations in mouse eggs.' Which biological process is linked to the process described by this evidence t... | egg activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00487","source_qa_id":"medium_divergent_branch_03605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein PLCZ1 is associated with multiple biological processes via the 'involved in' relation... | |
medium_divergent_branch_00488 | MRE11A interacts with multiple genes. One of these interactions is supported by experimental evidence using purified proteins, which indicated that the partner gene interacts with the MRN complex through both MRE11 and NBS1. Which cell type is the selected gene enriched in? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRE11A interacts with multiple genes. One of these interactions is supported by experimental evidence using purified proteins, which indicated that t... | |
medium_divergent_branch_00489 | STX11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Like other syntaxin family members, syntaxin 11 binds to the SNARE proteins VAMP and SNAP-23 in vitro and also exists in a complex with SNAP-23 in transfected HeLa cells and in native human B lymphocytes.' Which protein, encoded ... | Synaptosomal-associated protein 23 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00489","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Like other syntaxin family members, syntaxin 11 binds to t... | |
medium_divergent_branch_00490 | NFKB2 interacts with multiple genes. One of these interaction partners is reported to bind NF-κB specifically at its N-terminal region. Which disease is associated with this specific interaction partner? | endometrial carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00490","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB2 interacts with multiple genes. One of these interaction partners is reported to bind NF-κB specifically at its N-terminal region. Which disease... | |
medium_divergent_branch_00491 | E2F3 interacts with multiple genes. One of these interacting partners is described in a study reporting that a specific protein directly interacts with E2F1 to E2F3 and that its N terminus interacts with both the N and C termini of E2F1. Based on this description, identify the specific interacting partner of E2F3. Whic... | secondary neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F3 interacts with multiple genes. One of these interacting partners is described in a study reporting that a specific protein directly interacts wi... | |
medium_divergent_branch_00493 | CDK11A is reported to interact with multiple proteins. One specific interaction was identified using a yeast two-hybrid screening strategy, which found eukaryotic initiation factor 3 p47 protein as an interacting partner of the caspase-processed C-terminal kinase domain of CDK11 (CDK11(p46)). Which protein is encoded b... | Eukaryotic translation initiation factor 3 subunit F | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00493","source_qa_id":"medium_divergent_branch_06011","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CDK11A is reported to interact with multiple proteins. One specific interaction was identified us... | |
medium_divergent_branch_00494 | CCNA2 interacts with multiple genes. One of these interacting partners has been shown to bind specifically to the active Cyclin A/CDK2 complex in vitro and in vivo, but does not interact with Cyclin E or Cyclin B kinase complexes. Which disease is associated with this specific interacting gene? | Meier-Gorlin syndrome 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNA2 interacts with multiple genes. One of these interacting partners has been shown to bind specifically to the active Cyclin A/CDK2 complex in vit... | |
medium_divergent_branch_00496 | SUGT1 interacts with multiple proteins. One interaction is characterized by the finding that Sgt1 binds to the partner protein in a calcium-regulated manner, with the binding domain in Sgt1 consisting of 71 C-terminal residues. Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein S100-A6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00496","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUGT1 interacts with multiple proteins. One interaction is characterized by the finding that Sgt1 binds to the partner protein in a calcium-regulated... | |
medium_divergent_branch_00497 | PITX3 is associated with multiple biological processes. One association is supported by evidence stating: 'These data strongly suggest a role for PITX3 in ASMD and cataracts and provide new evidence of the contribution of the RIEG/PITX gene family to the developmental program underpinning normal eye formation.' Which b... | anatomical structure morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00497","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PITX3 is associated with multiple biological processes. One association is supported by evidence stating: 'These data strongly suggest a role for PIT... | |
medium_divergent_branch_00498 | The gene AACS is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 12.22 TPM, a z-score of 1.77, and a fold enrichment of 2.63. Which cell type, connected to AACS via this enrichment evidence, is a subclass of dendritic cells? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AACS is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 12.22 TPM, a z... | |
medium_divergent_branch_00499 | Primate erythroparvovirus 1 upregulates multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.133 and an adjusted p-value of 0.03807. Which disease is associated with the gene targeted by this specific upregulation event via genomic alterations? | spinocerebellar ataxia 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00499","source_qa_id":"medium_divergent_branch_05895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates multiple genes. One specific upregulation event is charac... | |
medium_divergent_branch_00500 | PTGES3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa = any amino acid) in these proteins with the N-terminal Myeloid Nervy and DEAF-... | Egl nine homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTGES3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we show that the heat shock protein 90 (HS... | |
medium_divergent_branch_00502 | LILRB4 is associated with multiple biological processes. One specific association is supported by evidence showing that high surface expression of LILRB4 on THP-1 cells and primary peripheral blood monocytes profoundly inhibits the production of the pro-inflammatory cytokine TNF-alpha induced by FcgammaRI (CD64). Which... | tumor necrosis factor production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00502","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LILRB4 is associated with multiple biological processes. One specific association is supported by evidence showing that high surface expression of LI... | |
medium_divergent_branch_00503 | BRMS1 is associated with multiple molecular functions. One specific interaction is characterized by evidence that BRMS1 immunoprecipitates with the RelA/p65 subunit of NF-kappaB, with protein-protein interactions occurring at the C terminus region of the rel homology domain but not at its known transactivation domains.... | RNA polymerase II-specific DNA-binding transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00503","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRMS1 is associated with multiple molecular functions. One specific interaction is characterized by evidence that BRMS1 immunoprecipitates with the R... | |
medium_divergent_branch_00504 | The sweat gland placode is a subtype of two distinct anatomical categories. One of these categories is defined by the evidence that the sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud. Which anatomical category is connected to the sweat gland placode through the 'is a' rel... | ectodermal placode | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00504","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The sweat gland placode is a subtype of two distinct anatomical categories. One of these categories is defined by the evidence that the sweat gland p... | |
medium_divergent_branch_00505 | MAD2L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Surprisingly, hMAD2 also binds to the hREV7-binding sequence in hREV3, whereas hMAD2 does not bind to a similar sequence in ADAM9 or ELK-1 and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.' Which protein,... | DNA polymerase zeta catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00505","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAD2L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Surprisingly, hMAD2 also binds to the hREV7-binding seque... | |
medium_divergent_branch_00506 | TLR4 is associated with multiple biological processes. One of these processes is specifically linked to the uptake of Gram-negative bacteria, although the precise mechanisms are not fully understood. Which cell type is identified as enabling this specific biological process? | phagocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00506","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TLR4 is associated with multiple biological processes. One of these processes is specifically linked to the uptake of Gram-negative bacteria, althoug... | |
medium_divergent_branch_00507 | SFRP4 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest sFRP4 promotes epidermal differentiation.' Which biological process is positively regulated by the process linked to SFRP4 via this specific evidence? | epidermal cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP4 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest sFRP4 promotes epiderma... | |
medium_divergent_branch_00508 | ESR2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the vitamin D receptor (VDR) and estrogen receptor beta interact with different alpha-helical LXXLL motifs of a coactivator protein.' Which protein, encoded by the gene connected to ESR2 via this specific interaction... | Nuclear receptor coactivator 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESR2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the vitamin D receptor (VDR) and estrogen rec... | |
medium_divergent_branch_00509 | MAGT1 interacts with multiple proteins. One interaction partner is a subunit of the oligosaccharyltransferase (OST) complex and is required for Dengue virus (DENV) propagation. Which protein, connected to MAGT1 via a binding interaction, fits this description and is encoded by the gene in question? | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00509","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGT1 interacts with multiple proteins. One interaction partner is a subunit of the oligosaccharyltransferase (OST) complex and is required for Dengu... | |
medium_divergent_branch_00510 | CRYAB interacts with multiple genes. One interaction is supported by evidence that FGF-2, NGF-beta, VEGF, insulin, and a specific transcription factor co-activator exhibit strong interactions with human alphaB crystallin peptides, with specific interactive sequences identified. Which disease is connected to the gene im... | drug-induced hepatitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00510","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRYAB interacts with multiple genes. One interaction is supported by evidence that FGF-2, NGF-beta, VEGF, insulin, and a specific transcription facto... | |
medium_divergent_branch_00511 | SH3GL2 interacts with multiple proteins. One of these interaction partners is a member of the Nedd4/Rsp5p family of proteins, characterized by an N-terminal C2 domain, four WW domains, and a catalytic HECT domain. Distinctively, this protein possesses a short proline-rich domain that mediates its binding to the SH3 dom... | E3 ubiquitin-protein ligase Itchy homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00511","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3GL2 interacts with multiple proteins. One of these interaction partners is a member of the Nedd4/Rsp5p family of proteins, characterized by an N-t... | |
medium_divergent_branch_00512 | West Nile virus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.107 and an adjusted p-value of 0.00894. Which disease is associated with that selected gene? | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00512","source_qa_id":"medium_divergent_branch_03783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus downregulates several genes. In the recorded experiment, one branch showed a l... | |
medium_divergent_branch_00513 | MIR155 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-155 in dendritic cells inhibits the production of IL-6 and IL-1β while promoting IL-10 expression. Which biological process, connected to the process supported by this evidence via a 'negatively ... | cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00513","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR155 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-155 in dendritic cells i... | |
medium_divergent_branch_00514 | RIG-I (encoded by DDX58) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by this protein.' Identify the full protein name encoded by the gene that interacts with DDX58 and is described by this... | E3 ubiquitin-protein ligase RNF125 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIG-I (encoded by DDX58) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we found that RIG-I undergoes pro... | |
medium_divergent_branch_00515 | PPM1B interacts with multiple proteins. One interaction is supported by evidence stating: 'For the first time, we found that TNF-alpha stimulation enhances the interactions between 14-3-3 epsilon and some key components in the mitogen-activated protein kinase (MAPK) signal module which is located at the immediate upstr... | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPM1B interacts with multiple proteins. One interaction is supported by evidence stating: 'For the first time, we found that TNF-alpha stimulation en... | |
medium_divergent_branch_00516 | The gene ZMYND10 shows significant enrichment in multiple immune cell types. One specific cell type exhibits a mean expression of 9.31 TPM, a z-score of 3.07, and a fold enrichment of 14.38. Which cell type corresponds to these expression statistics, and what is its immediate parent category in the cell type hierarchy ... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ZMYND10 shows significant enrichment in multiple immune cell types. One specific cell type exhibits a mean expression of 9.31 TPM, a z-score... | |
medium_divergent_branch_00517 | KIF11 (also known as Eg5) interacts with a protein that is part of a complex described as a major ubiquitin ligase catalysing histone H2B monoubiquitination, which interacts with Eg5 during mitosis and participates in spindle assembly. Which protein, connected to KIF11 through an interaction, is the specific component ... | E3 ubiquitin-protein ligase BRE1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF11 (also known as Eg5) interacts with a protein that is part of a complex described as a major ubiquitin ligase catalysing histone H2B monoubiquit... | |
medium_divergent_branch_00518 | MAP3K5 interacts with multiple genes. One interaction is supported by evidence stating: 'The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAPKKKs), including MTK1 (MEKK4), ASK1, TAK1, TAO2, MEKK1, and Raf-1.' Which disease is associated with the gene involved in this specific interaction via a b... | hyperglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00518","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple genes. One interaction is supported by evidence stating: 'The DVD sites bind to their specific upstream MAP kinase kin... | |
medium_divergent_branch_00519 | hsa-miR-185-5p is reported to regulate the development of a specific cell type through the targeting of mRNAs including Mzb1. Which anatomical structure is that cell type a part of? | T cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00519","source_qa_id":"medium_divergent_branch_06693","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"hsa-miR-185-5p is reported to regulate the development of a specific cell type through the target... | |
medium_divergent_branch_00520 | PSMA7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 gamma was confirmed by co-immunoprecipitation and pull-down assays.' Which disease is associated with the gene identified by this evidence through genomic alterations? | coronary aneurysm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00520","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 gamma ... | |
medium_divergent_branch_00521 | JAK2 interacts with multiple genes. One of these interaction partners is characterized by its association with Jak3 and JAK2 tyrosine kinases via its ITAM region, and it is phosphorylated by Jak3 and JAK2 upon stimulation with IL-2 and GM-CSF, respectively. Which cellular component is this specific interaction partner ... | ESCRT-0 complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK2 interacts with multiple genes. One of these interaction partners is characterized by its association with Jak3 and JAK2 tyrosine kinases via its... | |
medium_divergent_branch_00522 | GPR35 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 23.44 TPM, a z-score of 1.56, and a fold enrichment of 3.77. Which cell type corresponds to this specific expression profile? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR35 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 23.44 TPM, a z-score of 1.56, and... | |
medium_divergent_branch_00523 | NEDD4L is associated with multiple biological processes. One association is supported by evidence that co-expression of Nedd4-2 (the Nedd4-like family isoform with the highest expression in the human heart) reduces KCNQ1 and KCNQ1/KCNE1 currents. Which biological process is negatively regulated by the process linked to... | potassium ion export across plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00523","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEDD4L is associated with multiple biological processes. One association is supported by evidence that co-expression of Nedd4-2 (the Nedd4-like famil... | |
medium_divergent_branch_00524 | PIAS3 interacts with multiple genes. One specific interaction is described as follows: 'Here, we identify that the small ubiquitin-like modifier (SUMO) E3-ligase, PIAS3, interacts with this gene and is required for increased Rac activation and optimal cell migration in response to hepatocyte growth factor (HGF) signall... | rhabdomyosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS3 interacts with multiple genes. One specific interaction is described as follows: 'Here, we identify that the small ubiquitin-like modifier (SUM... | |
medium_divergent_branch_00525 | hsa-miR-21-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n=13, <3 years prior to diagnosis) when compared with HI... | B cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00525","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-21-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'We show that microRNA-21 is significantly ... | |
medium_divergent_branch_00526 | The gene IRAK2 is enriched in multiple cell types. One specific cell type shows a mean expression of 7.85 TPM, a z-score of 1.91, and a fold enrichment of 4.32. Which cell type develops from the progenitor of this specific cell? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00526","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IRAK2 is enriched in multiple cell types. One specific cell type shows a mean expression of 7.85 TPM, a z-score of 1.91, and a fold enrichme... | |
medium_divergent_branch_00527 | TRIM59 interacts with multiple genes. One specific interaction is supported by mechanistic evidence showing that TRIM59 physically binds to a partner protein, induces its ubiquitination, and causes its proteasome-dependent degradation. Which disease is associated with this specific interacting partner? | partial lipodystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM59 interacts with multiple genes. One specific interaction is supported by mechanistic evidence showing that TRIM59 physically binds to a partner... | |
medium_divergent_branch_00528 | YME1L1 is associated with multiple biological processes. One association is supported by evidence stating: 'Understanding how YME1L recognizes substrates and catalyses ATP-dependent degradation has been hampered by the presence of an insoluble transmembrane anchor that drives hexamerization of the catalytic domains to ... | protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YME1L1 is associated with multiple biological processes. One association is supported by evidence stating: 'Understanding how YME1L recognizes substr... | |
medium_divergent_branch_00529 | CCDC66 is associated with multiple biological processes. One specific association is supported by the finding that CCDC66 acts as a targeting factor for centrosome and cilium proteins. Which broader biological process is a parent of this specific process in the ontology hierarchy? | regulation of protein localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00529","source_qa_id":"medium_divergent_branch_00386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CCDC66 is associated with multiple biological processes. One specific association is supported by... | |
medium_divergent_branch_00530 | RIPK1 interacts with multiple proteins. One specific interaction is supported by evidence stating that a protein kinase can be co-immunoprecipitated with RIP, TRAF2, and TNFR1 in mammalian cells. Which disease is associated with the gene encoding the protein that interacts with RIPK1 in this context? | cervical cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIPK1 interacts with multiple proteins. One specific interaction is supported by evidence stating that a protein kinase can be co-immunoprecipitated ... | |
medium_divergent_branch_00531 | PELI3 interacts with multiple proteins. One interaction is supported by evidence that Pellino3 directly binds to a kinase and catalyzes its ubiquitination. Which protein product is encoded by the gene corresponding to this interacting partner? | Receptor-interacting serine/threonine-protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PELI3 interacts with multiple proteins. One interaction is supported by evidence that Pellino3 directly binds to a kinase and catalyzes its ubiquitin... | |
medium_divergent_branch_00532 | CCND1 interacts with multiple proteins. One specific interaction is described as follows: 'Here, we demonstrate that cyclin D1, via amino acids 20-90, interacts with the C-terminal domain of this protein, and that this interaction is increased in response to DNA damage.' Which protein is encoded by the gene correspondi... | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND1 interacts with multiple proteins. One specific interaction is described as follows: 'Here, we demonstrate that cyclin D1, via amino acids 20-90... | |
medium_divergent_branch_00533 | The gene DYNC1LI2 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In vitro pull-down assays demonstrated that this interaction partner directly binds to the cytoplasmic dynein 1 light intermediate chain 2.' Which protein is encoded by the gene corresponding to th... | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00533","source_qa_id":"medium_divergent_branch_03271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene DYNC1LI2 is known to interact with multiple proteins. One specific interaction is suppor... | |
medium_divergent_branch_00535 | COQ5 is annotated to multiple cellular components via the 'located in' relationship. One annotation specifies that the COQ5 polypeptide is associated with the mitochondrial inner membrane on the matrix side. Which cellular component, connected to the specific location implied by this evidence through an 'is a' relation... | intracellular organelle lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COQ5 is annotated to multiple cellular components via the 'located in' relationship. One annotation specifies that the COQ5 polypeptide is associated... | |
medium_divergent_branch_00536 | CLN5 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings indicate that expression of CLN-1 and CLN-5 may be significant for development of a wide range of maturating neurons.' Which biological process, connected to the process indicated by this evidence vi... | neuron development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00536","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLN5 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings indicate that expression of ... | |
medium_divergent_branch_00537 | STAT1 is involved in multiple biological processes. One specific process is supported by evidence showing that transfection of HUVECs with short interfering RNA targeting STAT1 abrogated IFN-gamma-induced inhibition of HUVEC growth and tube formation, and suppressed the inhibition of VEGF-induced tube formation by IFN-... | endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00537","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAT1 is involved in multiple biological processes. One specific process is supported by evidence showing that transfection of HUVECs with short inte... | |
medium_divergent_branch_00538 | Pancrelipase interacts with multiple drugs. One specific interaction involves a drug that, when combined with Cimetidine in certain doses, is reported to be sufficient to produce maximal improvement in the digestive activity of pancreatic supplements. Which disease is this specific drug indicated for? | metabolic acidosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00538","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pancrelipase interacts with multiple drugs. One specific interaction involves a drug that, when combined with Cimetidine in certain doses, is reporte... | |
medium_divergent_branch_00539 | JAG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both Jagged1(WT) and Jagged1(Ndr) interacted with the E3 ubiquitin ligase Mind bomb, but only Jagged1(WT) showed enhanced ubiquitylation after co-culture with cells expressing Notch receptor.' Which protein, connected to JAG1 via ... | E3 ubiquitin-protein ligase MIB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00539","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both Jagged1(WT) and Jagged1(Ndr) interacted with the E3 ub... | |
medium_divergent_branch_00540 | METTL18 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We found METTL18 to be a nuclear protein that contains a functional nuclear localization signal and accumulates in nucleoli.' Which cellular component, connected to the component... | intracellular membraneless organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"METTL18 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We foun... | |
medium_divergent_branch_00541 | STX17 interacts with multiple proteins. One interaction partner is an R-SNARE protein that exists as a SNARE domain-disrupted isoform (entityB) which competes with its functional isoform (entityA) to bind STX17, thereby inhibiting autophagosome-lysosome fusion. Which protein is encoded by the gene corresponding to this... | Vesicle-associated membrane protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX17 interacts with multiple proteins. One interaction partner is an R-SNARE protein that exists as a SNARE domain-disrupted isoform (entityB) which... | |
medium_divergent_branch_00542 | FGFR3 interacts with multiple proteins. One of these interaction partners is a component of chaperone complexes with which FGFR3 strongly associates, depending on them for stability and function. Which protein is encoded by the gene corresponding to this specific interaction partner? | Heat shock protein HSP 90-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00542","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGFR3 interacts with multiple proteins. One of these interaction partners is a component of chaperone complexes with which FGFR3 strongly associates,... | |
medium_divergent_branch_00543 | The epithelial cell of Malassez is anatomically part of two distinct structures. One of these structures is defined by evidence stating: 'An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth.' Which of the two candidate structures is connected to the... | mouth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00543","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The epithelial cell of Malassez is anatomically part of two distinct structures. One of these structures is defined by evidence stating: 'An epitheli... | |
medium_divergent_branch_00544 | The human calcium-sensing receptor (CASR) is described as a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca2+ homeostasis in the blood. CASR enables multiple molecular functions. One of these functions is defined by the receptor's classification as a GPCR. Which molecular function, connected to... | transmembrane signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The human calcium-sensing receptor (CASR) is described as a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca2+ homeostasis in... | |
medium_divergent_branch_00545 | BMI1 interacts with multiple genes. One of these interaction partners is a polycomb group protein that serves as a core component of PRC2 and physically interacts with PRC1. Which disease is associated with this specific gene through genomic alterations? | Weaver syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMI1 interacts with multiple genes. One of these interaction partners is a polycomb group protein that serves as a core component of PRC2 and physica... | |
medium_divergent_branch_00546 | DHX37 is associated with multiple biological processes. One specific association is supported by the finding that 'the DEAH-box RNA helicase DHX37 is required for maturation of the small ribosomal subunit in human cells.' Which biological process, connected to the process implied by this evidence via an 'is a' relation... | ribonucleoprotein complex biogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00546","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DHX37 is associated with multiple biological processes. One specific association is supported by the finding that 'the DEAH-box RNA helicase DHX37 is... | |
medium_divergent_branch_00547 | PFN1 interacts with multiple proteins. One of these interaction partners is described in the literature as having a proline-rich domain and directly interacting with profilin. Which protein, encoded by the gene connected to PFN1 via this specific interaction, is the subject of this description? | Protein enabled homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00547","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFN1 interacts with multiple proteins. One of these interaction partners is described in the literature as having a proline-rich domain and directly ... | |
medium_divergent_branch_00548 | UBXN1 interacts with multiple gene products. Experimental evidence indicates that the protein 2B28 specifically interacts and colocalizes with the protein product of one of these interacting genes, but does not interact with Homer1 proteins. Which protein is encoded by the gene that interacts with UBXN1 and matches thi... | Homer protein homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBXN1 interacts with multiple gene products. Experimental evidence indicates that the protein 2B28 specifically interacts and colocalizes with the pr... | |
medium_divergent_branch_00549 | The gene SNCA is known to interact with multiple proteins. One specific interaction partner is characterized by experimental evidence showing that wild-type and A53T mutant alpha-synuclein interact with this protein and suppress its peptidase activity. Which protein corresponds to this interaction partner? | ATP-dependent Clp protease proteolytic subunit, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SNCA is known to interact with multiple proteins. One specific interaction partner is characterized by experimental evidence showing that wi... | |
medium_divergent_branch_00551 | DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'We also found that the PDZ1 domain of PSD95, a postsynaptic scaffolding protein, interacted with the C terminus of a low-density lipoprotein receptor-related protein via an alternatively spliced, intracellular exon.' Which disease is... | myocardial infarction, susceptibility to | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00551","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'We also found that the PDZ1 domain of PSD95, a postsynaptic sc... | |
medium_divergent_branch_00553 | RAB21 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report the crystal structure of the [interacting partner] catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway.' Which gene, among those interacting with RAB21, ... | TBC1D3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB21 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report the crystal structure of the [intera... | |
medium_divergent_branch_00554 | DUSP16 interacts with multiple kinases. One specific interaction is supported by evidence stating that MKP-7 binds to and inactivates a specific MAPK and JNK/SAPK, but not ERK. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the 'encodes' relationship? | Mitogen-activated protein kinase 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00554","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DUSP16 interacts with multiple kinases. One specific interaction is supported by evidence stating that MKP-7 binds to and inactivates a specific MAPK... | |
medium_divergent_branch_00557 | NFKBIB interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific protein also interacted with IkappaB alpha and IkappaB beta. Which protein is encoded by the gene corresponding to this specific interaction partner? | Zinc finger and BTB domain-containing protein 7A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_00557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKBIB interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific protein also interacted with Ikappa... |
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