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2,326,200 | Adult neurogenesis is necessary to refine and maintain circuit specificity. | The circuitry of the olfactory bulb contains a precise anatomical map that links isofunctional regions within each olfactory bulb. This intrabulbar map forms perinatally and undergoes activity-dependent refinement during the first postnatal weeks. Although this map retains its plasticity throughout adulthood, its organ... |
2,326,201 | Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain. | The maintenance of a neural stem cell (NSC) population in mammalian postnatal and adult life is crucial for continuous neurogenesis and neural repair. However, the molecular mechanism of how NSC populations are maintained remains unclear. Gangliosides are important cellular membrane components in the nervous system. We... |
2,326,202 | Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. | Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related neurotoxins, in the brains of rats and adult nonhuman primates (cynomolgus macaques). Soluble Aβ oligomers are known to accumu... |
2,326,203 | The use of transcallosal-interforniceal approach for microsurgical removal of the third ventricle tumors. | The third ventricle is located deep in the brain and is adjacent to important neurovascular structures. This makes tumor resection in this region difficult and causes more postoperative complications than surgeries in other regions of the brain. The objective of this study was to investigate the feasibility and clinica... |
2,326,204 | Endogenous neural stem/progenitor cells stabilize the cortical microenvironment after traumatic brain injury. | Although a myriad of pathological responses contribute to traumatic brain injury (TBI), cerebral dysfunction has been closely linked to cell death mechanisms. A number of therapeutic strategies have been studied in an attempt to minimize or ameliorate tissue damage; however, few studies have evaluated the inherent prot... |
2,326,205 | Comparison of cortical and white matter traumatic brain injury models reveals differential effects in the subventricular zone and divergent Sonic hedgehog signaling pathways in neuroblasts and oligodendrocyte progenitors. | The regenerative capacity of the central nervous system must be optimized to promote repair following traumatic brain injury (TBI) and may differ with the site and form of damage. Sonic hedgehog (Shh) maintains neural stem cells and promotes oligodendrogenesis. We examined whether Shh signaling contributes to neuroblas... |
2,326,206 | Alterations in tight junction protein and IgG permeability accompany leukocyte extravasation across the choroid plexus during neuroinflammation. | The choroid plexus (CP) is considered to be a point of leukocyte entry into the CNS during normal immune surveillance and in neuroinflammatory diseases. The structural and functional alterations within the CP that support this migration are not understood. We used quantitative, high-resolution, 3-dimensional (3-D) fluo... |
2,326,207 | Neurocutaneous melanosis in association with dandy-walker complex with extensive intracerebral and spinal cord involvement. | Neurocutaneous melanosis (NCM) is a rare congenital syndrome consisting of benign or malignant melanotic tumors of the central nervous system with large or numerous cutaneous melanocytic nevi. The Dandy-Walker complex (DWC) is characterized by an enlarged posterior fossa with high insertion of the tentorium, hypoplasia... |
2,326,208 | Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings. | The present study aimed to evaluate the radiological and pathological features of intracranial hemangiopericytoma, and improve the understanding of this tumor. A retrospective analysis of radiological and pathological features of five cases of intracranial hemangiopericytoma was conducted between 2006 and 2012 in the S... |
2,326,209 | Intracranial pure yolk sac tumor in the anterior third ventricle of an adult: A case report. | A 45-year-old female patient presented with symptoms of polydipsia and polyuria, menopause, headache, gait disturbance and deteriorated mental state. Brain magnetic resonance imaging (MRI) showed an irregular mass in the anterior third ventricle. The tumor was excised using a transfrontal approach from the anterior sec... |
2,326,210 | In vivo study of cerebral white matter in the dog using diffusion tensor tractography. | Conventional magnetic resonance imaging (MRI) allows investigators and clinicians to observe the anatomy and injuries of the cerebral white matter (CWM) in dogs. However, dynamic images based on the diffusion tensor (DT) technique are required to assess fiber tract integrity of the CWM. Diffusion tensor tractography (D... |
2,326,211 | Prenatal diagnosis of giant left ventricular diverticulum: case report.<Pagination><StartPage>395</StartPage><EndPage>397</EndPage><MedlinePgn>395-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/echo.12781</ELocationID><Abstract><AbstractText>The distinction between a ventricular aneurysm and ... | The distinction between a ventricular aneurysm and diverticulum is difficult. The differences between these two are based on anatomical, histological, and functional criteria. We present a case of prenatal diagnosis of a giant left ventricular outpouching at 28 weeks gestation. During the postnatal period, the neonate ... |
2,326,212 | Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction.<Pagination><StartPage>345</StartPage><EndPage>356</EndPage><MedlinePgn>345-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/FJC.0000000000000127</ELocationID><Abstract><AbstractTex... | Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this quest... |
2,326,213 | Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation. | Insights into the mechanisms of development of the mammalian four-chambered heart are based on biological observations at organ, tissue, cell, and molecular levels, but the full integration of these experimental data awaits a systems biology approach. Such an approach can be employed to formulate and test conceptual mo... |
2,326,214 | [Pathologic-anatomic and morphometric examinations on the heart in feral cockatoos]. | To evaluate the heart of free-living psittacine birds macroscopically and morphologically, and to compare the results to findings published for psittacine birds living in captivity to obtain information on the influence of bird keeping in a human environment on the psittacine heart.</AbstractText>In total, 84 wild-livi... |
2,326,215 | Biomarkers for disease progression and AAV therapeutic efficacy in feline Sandhoff disease. | The GM2 gangliosidoses, Tay-Sachs disease (TSD) and Sandhoff disease (SD), are progressive neurodegenerative disorders that are caused by a mutation in the enzyme β-N-acetylhexosaminidase (Hex). Due to the recent emergence of novel experimental treatments, biomarker development has become particularly relevant in... |
2,326,216 | [Pathognomonic magnetic resonance imaging (MRI) finding of fluid-fluid level in pyogenic ventriculitis: two case reports]. | Pyogenic ventriculitis is an uncommon and potentially fatal central nervous system infection. Delayed treatment due to non specific clinical symptoms may lead to an unfavorable outcome. Brain magnetic resonance imaging (MRI) plays an important role in the diagnosis of pyogenic ventriculitis. We describe two patients wi... |
2,326,217 | [Lymphocytic primary angiitis of the central nervous system with fan-shaped linear enhancement converging to the lateral ventricles: a case report]. | We report a case of lymphocytic primary angiitis of the central nervous system (PACNS) with a characteristic gadolinium-enhancement pattern on magnetic resonance imaging (MRI). A 48-year-old, right-handed man presented with a 3-month history of tremor and progressing dementia. Neurologic examination revealed cognitive ... |
2,326,218 | Central V1b receptor antagonism in lactating rats: impairment of maternal care but not of maternal aggression. | Maternal behaviour in rodents is mediated by the central oxytocin and vasopressin systems, amongst others. The role of vasopressin, acting via the V1a receptor (V1aR), on maternal care and maternal aggression has recently been described. However, a potential involvement of the V1b receptor (V1bR) in maternal behav... |
2,326,219 | Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats.<Pagination><StartPage>67</StartPage><EndPage>74</EndPage><MedlinePgn>67-74</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The aim of... | The aim of this study was to identify the effects of swimming training on the mRNA expression and protein levels of the calcium handling proteins in the hearts of renovascular hypertensive rats submitted to swimming protocol during 6 weeks.</AbstractText>Fischer rats with renovascular hypertension 2-kidney 1-clip (2K1C... |
2,326,220 | [Subependymal microgliocytes of the third ventricle of the brain]. | The goal of the study was to identify the subependymal microglial cells of the III ventricle of the rat brain and to determine their structural characteristics. The sections of the brain of intact Wistar (n = 3) and Sprague-Dawley (n = 3) male rats were studied using the methods of immunocytochemistry and confocal lase... |
2,326,221 | [Treatment of child hydrocephalus by endoscopic third ventriculostomy in Senegal]. | Since its advent, endoscopic third ventriculostomy (ETV) has been an effective alternative to shunt placement for the treatment of hydrocephalus. The aim of this study was to report the results of our experience with this technique in children in Senegal.</AbstractText>This was a retrospective study of 70 cases of chil... |
2,326,222 | Assessment of sedated pediatric brain with 3D-FLAIR sequence at 3T MRI. | In sedated pediatric brains, 2D-FLAIR causes increased signal intensity of the cerebrospinal fluid (CSF) leading to false-positive diagnoses. Our aim is to determine whether increased CSF signal intensity is observed on 3D-FLAIR images.</AbstractText>In this institutional review board-approved study, a 2-year retrospec... |
2,326,223 | Brainstem oligodendroglial tumors in children: two case reports and review of literatures. | There is little information on pediatric oligodendroglial tumor located in the brainstem because of its rarity.</AbstractText>Here, we present two pediatric cases of pontine oligodendroglial tumors with radiological findings atypical for diffuse intrinsic pontine glioma.</AbstractText>The first patient was an 8-year-ol... |
2,326,224 | Subcortical structures in amyotrophic lateral sclerosis. | The aim of this study was to assess the involvement of deep gray matter, hippocampal subfields, and ventricular changes in patients with amyotrophic lateral sclerosis (ALS). A total of 112 ALS patients and 60 healthy subjects participated. High-resolution T1-weighted images were acquired using a 3T MRI scanner. Thirty-... |
2,326,225 | Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats. | Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state. We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP ... |
2,326,226 | Effects of ghrelin on protein expression of antioxidative enzymes and iNOS in the rat liver. | We investigated the effects of ghrelin on protein expression of the liver antioxidant enzymes superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), nuclear factor κB (NFκB) and inducible nitric oxide synthase (iNOS). Furthermore, we aimed to investigate ... |
2,326,227 | Treatment outcome of radiation therapy for intracranial germinoma: adaptive radiation field in relation to response to chemotherapy. | To determine the optimal radiotherapy (RT) target volume in correlation with tumor response to chemotherapy in patients with intracranial germinoma.</AbstractText>Seventy-two patients received chemotherapy followed by RT. The RT field was tailored to chemotherapy response.</AbstractText>Five-year recurrence-free surviv... |
2,326,228 | Plasma cytokine levels are related to brain volumes in HIV-infected individuals. | HIV-infected individuals frequently exhibit brain dysfunction despite antiretroviral treatment. The neuropathological mechanisms underlying these abnormalities remain unclear, pointing to the importance of identifying biomarkers sensitive to brain dysfunction. We examined 74 medically stable HIV-infected individuals us... |
2,326,229 | Catalpol regulates function of hypothalamic-pituitary-adrenocortical-axis in an Alzheimer's disease rat model. | To investigate the regulating effects of catalpol on the hypothalamic-pituitary- adrenocortical-axis (HPA) in an Alzheimer's disease (AD) rat model.</AbstractText>Healthy male Wistar Rats were selected. The AD model was generated by orthotopic injection of beta-amyloid 25-35 (Abeta25-35) into the right lateral ventricl... |
2,326,230 | Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain. | CDKL3 has an important role in regulating cell growth and/or differentiation, and its inactivation is recently reported to be related to non-syndromic mild mental retardation (MR). MR is a common neurological disorder, predominantly characterized by impaired cognitive function. Though genetic factors play a very import... |
2,326,231 | Endoscopic supraorbital eyebrow approach for the surgical treatment of extraaxialand intraaxial tumors. | The supraorbital eyebrow approach is a minimally invasive technique that offers wide access to the anterior skull base region and parasellar area through asubfrontal corridor. The use of neuroendoscopy allows one to extend the approach further to the pituitary fossa, the anterior third ventricle, the interpeduncular ci... |
2,326,232 | Expanding indications for the extended endoscopic endonasal approach to hypothalamic gliomas: preliminary report. | Object In the last decade the indications for the endoscopic endonasal approach have been progressively expanded to include lesions that have not been traditionally considered amenable to resection through the transsphenoidal route. In this study, the authors analyze their experience with hypothalamic gliomas treated v... |
2,326,233 | Gross total resection of large cervical intramedullary ependymoma: demonstration of microsurgical techniques. | In adolescents and young adults, ependymomas are the most common intramedullary tumors in the spinal cord.These tumors arise from ependymal cell lining the ventricles and spinal canal. The clinical presentation of intramedullary ependymomas are variable and nonspecific. They usually present with diffuse back or neck pa... |
2,326,234 | The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart. | The present study examined the binding of the individual N- and C-lobes of calmodulin (CaM) to Cav1.2 at different Ca(2+) concentration ([Ca(2+)]) from ≈ free to 2mM, and found that they may bind to Cav1.2 Ca(2+)-dependently. In particular, using the patch-clamp technique, we confirmed that the N- or C-lobes can... |
2,326,235 | Amniotic fluid-derived stem cells demonstrated cardiogenic potential in indirect co-culture with human cardiac cells. | Amniotic fluid-derived stem cells (AFSC) have been shown to be broadly multipotent and non-tumorogenic. Previous studies of direct mixing of AFSC and neonatal rat ventricle myocytes indicated evidence of AFSC cardiogenesis. In this study, we examined human AFSC cardiogenic potential in indirect co-culture with human ca... |
2,326,236 | Classic form of hypoplastic left heart syndrome diagnosed post-natally: an autopsy report. | Hypoplastic left heart syndrome (HLHS) is a congenital heart disease, which, despite the current improved knowledge about its management and surgical treatment, is still associated with high mortality, especially in the early neonatal period and before the second stage of reconstruction surgery. The low rate of prenata... |
2,326,237 | Multivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life. | Little is known about the temporospatial shape characteristics of human lateral ventricles (LVs) during the first two years of life. This study aimed to delineate the morphological growth characteristics of LVs during early infancy using longitudinally acquired MR images in normal healthy infants.</AbstractText>24 heal... |
2,326,238 | Lipoastrocytoma: A rare case report and review of literature. | Lipoastrocytoma is an extremely rare tumor, with only a few cases described. We report a case of a low-grade astrocytoma occupying the right cortical lobe in the parafalcine location. The patient was admitted with headache, vomiting and altered sensorium for duration of 1 year. MRI revealed a large heterogeneous enhanc... |
2,326,239 | Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. | Inositol 1,4,5-trisphosphate receptor (IP3R) plays a pivotal role in the Ca2+ release process in a variety of cell types. Additionally, IP3R is distributed in ventricular intercalated discs, but its function(s) in this particular site remains unknown. Connexin (Cx43), the predominant gap junction (GJ) protein in ventri... |
2,326,240 | Synchronous congenital malignant rhabdoid tumor of the orbit and atypical teratoid/rhabdoid tumor--feasibility and efficacy of multimodal therapy in a long-term survivor. | Among infant malignancies, congenital tumors, especially those of the central nervous system (CNS), constitute a rather unique subgroup. Poor survival rates (28% in CNS tumors) may be attributed to the aggressive biology as well as specific therapeutic limitations innate to the young age of affected patients. Our patie... |
2,326,241 | Vascular hamartoma in the central nervous system of a foal. | Vascular hamartomas are non-neoplastic developmental anomalies of vessels. Cases of cerebral vascular hamartomas have been previously reported in dogs and cats. A 4-week-old Freiberger foal had shown persistent problems with breathing and swallowing since birth, and bilateral laryngeal paralysis was diagnosed. The foal... |
2,326,242 | Empowering imaging biomarkers of Alzheimer's disease. | In a previous report, we proposed a method for combining multiple markers of atrophy caused by Alzheimer's disease into a single atrophy score that is more powerful than any one feature. We applied the method to expansion rates of the lateral ventricles, achieving the most powerful ventricular atrophy measure to date. ... |
2,326,243 | Erratum. The Neuroradiology Journal 27: 452-455, 2014 - doi: 10.15274/NRJ-2014-10060 - www.centauro.it. Olfactory Neuroblastoma and Olfactory Ventricle. | Unfortunately, the affiliation of the author name, Antonella Bacci, was incorrectly listed as Antonella Bacci(1) instead of Antonella Bacci(3), and the affiliations were incorrectly listed as (1) Department of Neurosurgery, IRCCS Neurological Research Hospital; Bologna, Italy - (2) Section of Pathology "M. Malpighi", B... |
2,326,244 | Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. | Mechanical stretch of cardiac muscle modulates action potential propagation velocity, causing potentially arrhythmogenic conduction slowing. The mechanisms by which stretch alters cardiac conduction remain unknown, but previous studies suggest that stretch can affect the conformation of caveolae in myocytes and other c... |
2,326,245 | Radiofrequency cardiac ablation with catheters placed on opposing sides of the ventricular wall: computer modelling comparing bipolar and unipolar modes. | The aim of this study was to compare the efficacy of bipolar (BM) vs. unipolar (UM) mode of radiofrequency ablation (RFA) in terms of creating transmural lesions across the interventricular septum (IVS) and ventricular free wall (VFW).</AbstractText>We built computational models to study the temperature distributions a... |
2,326,246 | Factors that predict hydrocephalus following intraventricular hemorrhage. | To evaluate potential risk factors that can predict the development of hydrocephalus (HCP) in adult patients with intraventricular hemorrhage (IVH).</AbstractText>Retrospective analysis of all adult patients presented to King Fahad Medical City between 2004 and 2011 with intraventricular hemorrhage to evaluate differen... |
2,326,247 | Primary burkitt lymphoma of the fourth ventricle in an immunocompetent young patient. | Primary Burkitt lymphoma of the central nervous system (CNS) is rare, with only few cases reported in the literature. An 18 year-old immunocompetent male presented with multiple cranial nerves palsies and was found to have a mass predominantly in the 4th ventricle of the brain. Tumor was surgically removed and showed m... |
2,326,248 | Ependymal damage in a Plasmodium yoelii yoelii lethal murine malaria model. | Malaria continues to be a major global health problem, and over 40% of the world's population is at risk. Severe or complicated malaria is defined by clinical or laboratory evidence of vital organ dysfunction, including dysfunction of the central nervous system (CNS). The pathogenesis of complicated malaria has not bee... |
2,326,249 | [Role of controlled physical activity as a method of therapy in patients with heart failure after invasive treatment of angina pectoris].<Pagination><StartPage>77</StartPage><EndPage>81</EndPage><MedlinePgn>77-81</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">Due to the aging of the population is a... | The results of treatment of 334 patients in the clinic in 1984 - 2013 yrs period were analyzed, who suffered mitral valve stenosis, complicated by massive thrombosis of left atrium (LA). Hospital lethality while the mitral valve prosthesis (including those in combination with correction of a three-cuspid valve) have co... |
2,326,250 | Strain analysis from 4-D cardiac CT image data. | Strain is a discriminative parameter of regional myocardial dysfunction. Despite the large body of research on myocardial strain analysis in echocardiography and MR images, such techniques have not often been applied to cardiac CT data. Reasons for this include the challenges of sparse image deformation clues and the l... |
2,326,251 | Rapid deterioration of primary fourth ventricular outlet obstruction resulting in syndrome of inappropriate antidiuretic hormone secretion. | Fourth ventricular outlet obstruction (FVOO) is a rare cause of obstructive hydrocephalus. Although FVOO accompanied by malformative syndrome and secondary causes of obstruction are common, there are few reports of primary FVOO (PFVOO). The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a rare pres... |
2,326,252 | The clinical dilemma of quantifying mechanical left ventricular dyssynchrony for cardiac resynchronization therapy: segmental or global? | Heart failure (HF) represents a serious clinical and public cause of mortality, morbidity, as well as healthcare expenditures. Guidelines for treatment of HF join in recommending multimedical regimen at targeted doses as the best medical strategy, despite that a significant percentage of patients remain symptomatic. St... |
2,326,253 | Papillary glioneuronal tumor with an unusual bilateral intraventricular localization. | Papillary glioneuronal tumor (PGNT) is a rare brain tumor (World Health Organization grade I) with a glioneuronal dual nature. It has a characteristic morphological pattern composed of astroglial pseudopapillary structures and interpapillary neurocytic elements. The tumor usually occurs in the supratentorial region in ... |
2,326,254 | Tracheostomy in children with congenital heart disease: a national analysis of the Kids' Inpatient Database. | Background. While single-institution studies reported the indications and outcomes of tracheostomy in children with congenital heart disease (CHD), no national analyses have been performed. We sought to examine the indications, performance, outcomes, and resource utilization of tracheostomy in children with CHD using a... |
2,326,255 | Giant choroid plexus papilloma of the lateral ventricle in fetus. | Choroid plexus papillomas (CPPs) are rare tumors having bimodal distribution. Pediatric CPPs are commonly present in supratentorial compartment and most commonly located in lateral ventricle and usually present at 16-18 months. Authors could find only one case report of fetal choroid plexus papilloma in the literature.... |
2,326,256 | Shunt site chronic calcified extradural hematoma: An avoidable complication. | Extradural hematoma (EDH) after ventriculoperitoneal (VP) shunt procedure is a rare, dangerous but easily avoidable and manageable complication. It is more common in children and young adults presumably due to relatively lax adhesion of dura to calvarium. We report a case of an 18-year-old male with acqueductal stenosi... |
2,326,257 | Shunt malfunction presenting with symptomatic syringomyelia: Demonstrated on contrast ventriculogram. | Ventriculoperitoneal (VP) shunt malfunction commonly presents as raised intracranial pressure. Rarely, when the central canal of the spinal cord communicates with the 4(th) ventricle, shunt malfunction can present as an expanding syrinx. The diagnosis is often delayed, resulting in severe morbidity. Some of these patie... |
2,326,258 | Benign enlargement of sub-arachnoid spaces in infancy. | Benign enlargement of sub-arachnoid spaces (BESS) is one of the causes of macrocephaly in infants. It is a self-limiting condition and does not require any active medical or surgical treatment. We report a case of an infant aged 4 months who was referred for magnetic resonance imaging (MRI) of the brain as the head cir... |
2,326,259 | [Reflection on the exfoliation of the tunic albuginea after the low-temperature plasma operation]. | To discuss the potential problems caused by the exfoliation of the tunic albuginea after the low-temperature plasma operation.</AbstractText>To observe the occurrence of the tunic albuginea, exfolliating time, wound healing and its complications by following the patients received the low-temperature plasma operation fr... |
2,326,260 | Safety of warfarin dosing in the intensive care unit following the Fontan procedure. | To determine the incidence of supratherapeutic international normalized ratio (INR) values in patients initiated on warfarin in the pediatric intensive care unit after the Fontan procedure.</AbstractText>Retrospective chart review.</AbstractText>Pediatric intensive care unit in a freestanding pediatric teaching hospita... |
2,326,261 | Electrospun polyurethane as an alternative ventricular catheter and in vitro model of shunt obstruction. | Intracranial pressure and volume vary considerably between hydrocephalic patients, and with age, health and haemodynamic status; if left untreated, intracranial pressure rises and the ventricular system expands to accommodate the excess cerebrospinal fluid, with significant morbidity and mortality. Cerebrospinal fluid ... |
2,326,262 | The interaction between microglia and neural stem/precursor cells. | In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. M... |
2,326,263 | 17β-estradiol rapidly facilitates lordosis through G protein-coupled estrogen receptor 1 (GPER) via deactivation of medial preoptic nucleus μ-opioid receptors in estradiol primed female rats. | In female rats sexual receptivity (lordosis) can be induced with either a single large dose of estradiol benzoate (EB), or a priming dose of EB that does not induce sexual receptivity followed by 17β-estradiol (E2). Estradiol priming initially inhibits lordosis through a multi-synaptic circuit originating in the ... |
2,326,264 | Role of inositol-1,4,5-trisphosphate receptor in the regulation of calcium transients in neonatal rat ventricular myocytes. | This study determined the regulatory effect of inositol 1,4,5-trisphosphate receptors (IP3Rs) on the basal Ca(2+) transients in cardiomyocytes. In cultured neonatal rat ventricular myocytes (NRVMs) at different densities, we used confocal microscopy to assess the effect of IP3Rs on the endogenous spontaneous Ca(2+) osc... |
2,326,265 | Neurodegeneration through oxidative stress: monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors. | Dementia is one of the big medical challenges of our time with Alzheimer's, Huntington's and Parkinson's disease among its most common forms. In year 2000, 4.5 million people were diagnosed with Alzheimer's disease in the United States. In the case of Alzheimer's disease one of many contributing factors is a metabolic ... |
2,326,266 | Endoscopic third ventriculostomy in the management of hydrocephalus: Outcome analysis of 168 consecutive procedures. | Endoscopic third ventriculostomy (ETV) is the treatment of choice for obstructive hydrocephalus, but the outcome is still controversial in terms of age and aetiology.</AbstractText>Between 1998 and 2011, 168 consecutive procedures were performed in 164 patients, primarily children (56%<18 years of age and 35%<2 y... |
2,326,267 | Central alarin ameliorated insulin resistance of adipocytes in type 2 diabetic rats. | Alarin, a regulatory peptide, belongs to the galanin family and plays the same regulatory roles as galanin in orexigenic activity and energy metabolism. Our previous studies had found that galanin might facilitate insulin sensitivity via activation of its central receptors. To date, little is known about whether centra... |
2,326,268 | Pediatric endoscopic third ventriculostomy: a population-based study. | Endoscopic third ventriculostomy (ETV) is an alternative to ventriculoperitoneal shunting for hydrocephalus treatment. Choice of treatment options raises questions about which patients are likely to benefit from ETV. The authors performed a population-based analysis using an administrative claims database, examining cu... |
2,326,269 | Variable relations of the trochlear nerve with the pontomesencephalic segment of the superior cerebellar artery. | The superior cerebellar artery (SCA) is, perhaps, the most anatomically constant cerebellar artery which, in its lateral pontomesencephalic course, is crossed above by the trochlear nerve (CNIV). The SCA may determine, as an offending vessel, CNIV compression and superior oblique myokymia and thus surgical decompressio... |
2,326,270 | Assessment of Right Ventricular Longitudinal Strain in Patients with Ischemic Cardiomyopathy: Head-to-Head Comparison between Two-Dimensional Speckle-Based Strain and Velocity Vector Imaging Using Volumetric Assessment by Cardiac Magnetic Resonance as a "Gold Standard". | Longitudinal strain of right ventricle (RV) can be used to determine RV systolic function. This study compared RV longitudinal strain values of two different speckle tracking software technologies, velocity vector imaging (VVI) and two-dimensional speckle tracking echocardiography (2DSTE), and longitudinal strain by ca... |
2,326,271 | [Intracerebral transplantation of human umbilical cord-derived mesenchymal stem cells in neonatal rat model of hypoxic-ischemic brain damage: protective effect to injured brain]. | To study the brain protection and the possible mechanism of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in neonatal rat model of hypoxic-ischemic brain damage (HIBD).</AbstractText>Successfully establishing a neonatal rat model of HIBD, hUC-MSCs labeled with BrdU were transplanted into the lateral ve... |
2,326,272 | Calcium movement in cardiac mitochondria. | Existing theory suggests that mitochondria act as significant, dynamic buffers of cytosolic calcium ([Ca(2+)]i) in heart. These buffers can remove up to one-third of the Ca(2+) that enters the cytosol during the [Ca(2+)]i transients that underlie contractions. However, few quantitative experiments have been presented t... |
2,326,273 | Current states of endogenous stem cells in adult spinal cord. | New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal cel... |
2,326,274 | Gender differences in normal left ventricle of adult FVB/N mice due to variation in interleukins and natriuretic peptides expression levels.<Pagination><StartPage>54</StartPage><EndPage>59</EndPage><MedlinePgn>54-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cyto.2014.08.008</ELocationID><... | This study examined the sex differences for physical, morphological, histological, mRNA, and protein expression levels changes for interleukins and natriuretic peptides in left ventricle (LV) of two groups of adult FVB/N mice; males (WM) and females (WF). LV morphological, histological, reverse transcription and quanti... |
2,326,275 | Adult neural stem cells stake their ground. | The birth of new neurons in the walls of the adult brain lateral ventricles has captured the attention of many neuroscientists for over 2 decades, yielding key insights into the identity and regulation of neural stem cells (NSCs). In the adult ventricular-subventricular zone (V-SVZ), NSCs are a specialized form of astr... |
2,326,276 | Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone. | We evaluated the influence of tumor location and tumor spread in primary glioblastoma (GBM), with respect to the subventricular zone (SVZ), on recurrence behavior, progression-free survival (PFS), and overall survival (OS).</AbstractText>607 patients (376 male and 231 female) with a median age of 61.3 years (range, 3.0... |
2,326,277 | Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. | ATP-binding cassette (ABC) transporters play an increasing role in the understanding of pathologic peptide deposition in neurodegenerative diseases (NDs), such as Alzheimer's and Parkinson's. To describe the location of the most important ABC transporters for NDs in human brain tissue, we investigated ABCB1 and ABCC1 i... |
2,326,278 | Factors associated with the improvement of vocal fold movement: an analysis of LEMG and laryngeal CT parameters. | The aim of this study is to elucidate the relationship of laryngeal electromyography (LEMG) and computed tomographic (CT) parameters to improve the prognosis of recurrent laryngeal nerve injury. 22 patients clinically suspected of having recurrent laryngeal nerve injury were examined with LEMG and CT studies. Bilateral... |
2,326,279 | Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. | With aging and in cardiac disease, fibrosis caused by collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study, we set out to identify genetic modifiers of collagen deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J... |
2,326,280 | Unpinning of scroll waves under the influence of a thermal gradient. | Three-dimensional scroll waves of electrical activity are among the mechanisms believed to be responsible for the rapid, unsynchronized contraction of cardiac ventricles, thereby reducing the heart's ability to pump blood. Scroll waves can attach themselves to unexcitable obstacles, and this sometimes highly elongates ... |
2,326,281 | Laser cell-micropatterned pair of cardiomyocytes: the relationship between basement membrane development and gap junction maturation. | The basement membrane (BM), a network of laminin and collagen IV, mechanically supports individual cells and directly mediates cell-cell and cell-extracellular matrix (ECM) interactions. For example, the BM network that tightly encloses each cardiomyocyte (CM) mediates the alignment of CMs with collagen I in the ECM. A... |
2,326,282 | Quadrigeminal cistern arachnoid cyst: A series of 18 patients and a review of literature. | Arachnoid cysts account for 1% of intracranial mass lesions. Quadrigeminal cistern arachnoid cysts are even rarer lesions. We report 18 cases of quadrigeminal cistern arachnoid cysts treated at our institute from 2002 to 2012.</AbstractText>We retrospectively analysed 18 patients with quadrigeminal cistern arachnoid cy... |
2,326,283 | Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. | The conserved habenular nuclei function as a relay system connecting the forebrain with the brain stem. They play crucial roles in various cognitive behaviors by modulating cholinergic, dopaminergic and serotonergic activities. Despite the renewed interest in this conserved forebrain region because of its importance in... |
2,326,284 | Understanding the timing cycles of a cardiac resynchronization device designed with left ventricular sensing. | Some devices used for cardiac resynchronization therapy (CRT) can sense from the left ventricular (LV) lead as in Biotronik CRT devices (Biotronik GmbH, Berlin, Germany), whose special LV timing cycles form the basis of this report. LV sensing (LVs) was designed to prevent competitive pacing outside the LV myocardial a... |
2,326,285 | Cellular specificity of the blood-CSF barrier for albumin transfer across the choroid plexus epithelium. | To maintain the precise internal milieu of the mammalian central nervous system, well-controlled transfer of molecules from periphery into brain is required. Recently the soluble and cell-surface albumin-binding glycoprotein SPARC (secreted protein acidic and rich in cysteine) has been implicated in albumin transport i... |
2,326,286 | Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. | Melanocortin receptors (MC3/4R) mediate most of the metabolic and cardiovascular actions of leptin.</AbstractText>Here, we tested if MC4R also contributes to leptin's effects on respiratory function.</AbstractText>After control measurements, male Holtzman rats received daily microinjections of leptin, SHU9119 (MC3/4R a... |
2,326,287 | Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. | Hyperprolactinaemia is a major cause of infertility in both males and females, although the mechanism by which prolactin inhibits the reproductive axis is not clear. The aim of the present study was to test the hypothesis that elevated prolactin causes suppression of kisspeptin expression in the hypothalamus, resulting... |
2,326,288 | Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. | Ganglioneuroblastomas (GNBs) are rare embryonic neoplasms in the spectrum of neuroblastic tumours and 80% of cases occur in the first decade. In adults, GNBs are usually located in the retroperitoneum, mediastinum and neck but intracranial GNBs are extremely rare.</AbstractText>A 34-year-old male applied to the Departm... |
2,326,289 | Primary culture of choroid plexuses from neonate rats containing progenitor cells capable of differentiation. | The choroid plexuses, which could secrete a number of neurotrophins, have recently been used in transplantation in central nervous system diseases.</AbstractText>To study the mechanism of nerve regeneration in the central nervous system by grafting choroid plexus tissues.</AbstractText>Animal experimentation.</Abstract... |
2,326,290 | Development of the sexually dimorphic nucleus of the preoptic area and the influence of estrogen-like compounds. | One of the well-defined sexually dimorphic structures in the brain is the sexually dimorphic nucleus, a cluster of cells located in the preoptic area of the hypothalamus. The rodent sexually dimorphic nucleus of the preoptic area can be delineated histologically using conventional Nissl staining or immunohistochemicall... |
2,326,291 | Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury. | Amyloid β-peptide, a major component of senile plaques in Alzheimer's disease, has been implicated in neuronal cell death and cognitive impairment. Recently, studies have shown that the pathogenesis of cerebral ischemia is closely linked with Alzheimer's disease. In this study, a rat model of global cerebral isch... |
2,326,292 | miR-137, a new target for post-stroke depression? | Expression of miR-137 is downregulated in brain tissue from patients with depression and suicidal behavior, and is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miR-137 acts as a bridge between stroke and depression. To test this, we used middle cerebral artery occlusion a... |
2,326,293 | Rigid endoscopic resection of deep-seated or intraventricular brain tumors. | Rigid endoscopic resection using a thick sheath (ViewSite) may be a viable method for the resection or biopsy of selected deep-seated brain tumors, such as thalamic gliomas and malignant lymphomas. Neuroendoscopic biopsy is one technique used for the histological verification of suspected brain tumors. There are a numb... |
2,326,294 | Diffusion tensor imaging of brain abnormalities induced by prenatal exposure to radiation in rodents. | We assessed brain abnormalities in rats exposed prenatally to radiation (X-rays) using magnetic resonance imaging (MRI) and histological experiments. Pregnant rats were divided into 4 groups: the control group (n = 3) and 3 groups that were exposed to different radiation doses (0.5, 1.0, or 1.5 Gy; n ... |
2,326,295 | Migration and differentiation of neural progenitor cells after recurrent laryngeal nerve avulsion in rats. | To investigate migration and differentiation of neural progenitor cells (NPCs) from the ependymal layer to the nucleus ambiguus (NA) after recurrent laryngeal nerve (RLN) avulsion. All of the animals received a CM-DiI injection in the left lateral ventricle. Forty-five adult rats were subjected to a left RLN avulsion i... |
2,326,296 | Effects of rearing density and dietary fat content on burst-swim performance and oxygen transport capacity in juvenile Atlantic salmon Salmo salar. | The effects of hatchery rearing density (conventional or one third of conventional density) and feeding regime (high or reduced dietary fat levels) on burst-swim performance and oxygen transport capacity were studied in hatchery-reared Atlantic salmon Salmo salar, using wild fish as a reference group. There was no effe... |
2,326,297 | Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury. | Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination with growth factors, induce lesion remodeling and repair. We found th... |
2,326,298 | Early Inflammatory Responses Following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events. | While multiple rodent preclinical studies, and to a lesser extent human clinical trials, claim the feasibility, safety, and potential clinical benefit of cell grafting in the central nervous system (CNS), currently only little convincing knowledge exists regarding the actual fate of the grafted cells and their effect o... |
2,326,299 | Transmediastinal and transcardiac gunshot wound with hemodynamic stability. | Cardiac injuries caused by knives and firearms are slightly increasing in our environment. We report the case of a 43-year-old male patient with a transmediastinal gunshot wound (TGSW) and a through-and-through cardiac wound who was hemodynamically stable upon his admission. He had an entrance wound below the left clav... |
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