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2,327,700 | SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. | Adolescent idiopathic scoliosis (AIS) affects 3% to 4% of children between the ages of 11 and 18 [1, 2]. This disorder, characterized by abnormal three-dimensional spinal curvatures that typically develop during periods of rapid growth, occurs in the absence of congenital vertebral malformations or neuromuscular defect... |
2,327,701 | The peculiarities of the body's external structure and indicators of central hemodynamics of volleyball players of different positions. | The aim was to determine the main differences in the external structure of the body and the of central hemodynamics parameters in of high-level sports skills volleyball players of the juvenile age with the role of libero, hitters and setters.</AbstractText>Materials and methods: 116 volleyball players of high level ath... |
2,327,702 | White Matter-Governed Superior Frontal Sulcus Surgical Paradigm: A Radioanatomic Microsurgical Study-Part I. | Frontal subcortical and intraventricular pathologies are traditionally accessed via transcortical or interhemispheric-transcallosal corridors.</AbstractText>To describe the microsurgical subcortical anatomy of the superior frontal sulcus (SFS) corridor.</AbstractText>Cadaveric dissections were undertaken and correlated... |
2,327,703 | Expanded endoscopic endonasal approach for extending suprasellar and third ventricular lesions. | Expanded endonasal approaches can provide direct access to the midline skull base from the anterior cranial fossa to the ventral foramen magnum. Surgical strategies of bone drilling, dural opening, and intradural dissection can determine the area of surgical exposure and instrument handling, affecting the safety of dev... |
2,327,704 | Choroid plexus coagulation in trisomy 9 mosaic-related hydrocephalus-a case report. | In trisomy 9 mosaicism, plexus hypertrophy has been described as a phenotypical feature and cause of hydrocephalus. We report on a 15-month-old child with hydrocephalus and trisomy 9 mosaicism primarily diagnosed in amniocentesis. After implantation of a ventriculoperitoneal shunt and subsequent revision, he presented ... |
2,327,705 | Near-complete regression 19 years after Gamma Knife radiosurgery of vestibular schwannoma with massive pseudoprogression: case report. | Gamma Knife radiosurgery (GKRS) is a frequent treatment choice for patients with small- to moderate-sized vestibular schwannoma (VS). However, pseudoprogression after GKRS is commonly observed, with a reported incidence ranging from 7% to 77%. The wide range of the reported incidence of pseudoprogression reflects the f... |
2,327,706 | The effect of successful parathyroid surgery on left ventricle function in patients with primary hyperparathyroidism evaluated with strain echocardiography.<Pagination><StartPage>670</StartPage><EndPage>677</EndPage><MedlinePgn>670-677</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/echo.14660</... | The article clarifies the diagnostic criteria for syntropic heart damage - cardiomyopathy in patients with Alcoholic Liver Cirrhosis before the clinical signs of heart damage appear. As a result of the examination of 64 patients with Cirrhotic Cardiomyopathy, of which 51 patients were identified without clinical signs ... |
2,327,707 | Trapped fourth ventricle: a rare complication in children after supratentorial CSF shunting. | Trapped fourth ventricle (TFV) is a well-identified problem in hydrocephalic children. Patients with post-hemorrhagic hydrocephalus (PHH) are mostly affected. We tried to find out predisposing factors and describe clinical findings to early diagnose TFV and manage it.</AbstractText>We reviewed our database from 1991 to... |
2,327,708 | A New Framework for Performing Cardiac Strain Analysis from Cine MRI Imaging in Mice. | Cardiac magnetic resonance (MR) imaging is one of the most rigorous form of imaging to assess cardiac function in vivo. Strain analysis allows comprehensive assessment of diastolic myocardial function, which is not indicated by measuring systolic functional parameters using with a normal cine imaging module. Due to the... |
2,327,709 | Racial Segregation and Intraventricular Hemorrhage in Preterm Infants. | Intraventricular hemorrhage (IVH) disproportionately affects black neonates. Other conditions that are more common in black neonates, including low birth weight and preterm delivery, have been linked with residential racial segregation (RRS). In this study, we investigated the association between RRS and IVH.</Abstract... |
2,327,710 | Multiple Large-Size Cystic Cerebral Cavernomas. | Cerebral cavernomas are vascular malformations characterized by networks of abnormally dilated capillaries. They typically present as nodules with mixed signal intensity and a surrounding hemosiderin rim on magnetic resonance imaging. They may occur as multiple lesions in the autosomal-dominant familial form. In rare c... |
2,327,711 | Choroid plexus and the blood-cerebrospinal fluid barrier in disease. | The choroid plexus (CP) forming the blood-cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lini... |
2,327,712 | Embryonic microglia influence developing hypothalamic glial populations. | Although historically microglia were thought to be immature in the fetal brain, evidence of purposeful interactions between these immune cells and nearby neural progenitors is becoming established. Here, we examined the influence of embryonic microglia on gliogenesis within the developing tuberal hypothalamus, a region... |
2,327,713 | Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation. | Both chronic hypoxia (CH) and long-term chronic intermittent hypoxia (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention to improve cardiac function and energy metabolism in cardiac hypertrophy. Likewise, caloric restriction (CR) also plays an important role in this card... |
2,327,714 | Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes. | <b>Introduction:</b> In ventricular myocytes, spontaneous release of calcium (Ca<sup>2+</sup>) from the sarcoplasmic reticulum via ryanodine receptors ("Ca<sup>2+</sup> sparks") is acutely increased by stretch, due to a stretch-induced increase of reactive oxygen species (ROS). In acute regional ischemia there is stret... |
2,327,715 | A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing. | Recently, age-related timing dissociation between the superficial and deep venous systems has been observed; this was particularly pronounced in patients with normal pressure hydrocephalus, suggesting a common mechanism of ventriculomegaly. Establishing the relationship between venous drainage and ventricular enlargeme... |
2,327,716 | A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons. | Vascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic effects on lesioned neurons. Hitherto, the administration of VEGF in different animal models of lesion or disease has been conducted following a chronic protocol of administration. We questioned whether... |
2,327,717 | Postoperative delayed trapped temporal horn in patients with lateral ventricular trigone meningioma: Risk factors, surgical management, and literature review. | To assess the risk factors for and surgical treatment of delayed trapped temporal horn (dTTH) in patients who had undergone removal of lateral ventricular trigone meningioma.</AbstractText>Patients with lateral ventricular trigone meningioma treated at our institution from 2011 to 2015 were identified. Predictors for d... |
2,327,718 | Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes. | Isolated adult rat ventricular cardiomyocytes (ARVC) adapt to the two-dimensional surface of culture dishes once they are isolated from the three-dimensional heart tissue. This process mimics aspects of cardiac adaptation to pressure overload and requires an initial breakdown of sarcomeric structures. The present study... |
2,327,719 | Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. | Several missense mutations in the orphan transporter FLVCR2 have been reported in Fowler syndrome. Affected subjects exhibit signs of severe neurological defects. We identified the mouse ortholog Mfsd7c as a gene expressed in the blood-brain barrier. Here, we report the characterizations of Mfsd7c-KO mice and compare t... |
2,327,720 | Smaller Left Ventricle Size at Noncontrast CT Is Associated with Lower Mortality in COPDGene Participants. | Background Smokers with chronic obstructive pulmonary disease (COPD) have smaller left ventricles (LVs) due to reduced preload. Skeletal muscle wasting is also common in COPD, but less is known about its contribution to LV size. Purpose To explore the relationships between CT metrics of emphysema, venous vascular volum... |
2,327,721 | Endoscopic Third Ventriculostomy for Hydrocephalus Secondary to Extraventricular Obstruction in Thalamic Hemorrhage: A Case Series. | Intracranial hemorrhage carries significant morbidity and mortality, particularly if associated with hydrocephalus. Management of hydrocephalus includes temporary external ventricular drainage, with or without shunting. Thalamic location is an independent predictor of mortality and increases the likelihood of shunt dep... |
2,327,722 | Giant Right Coronary Artery Aneurysm Resembling Cardiac Tumor: A Case Report.<Pagination><StartPage>E165</StartPage><EndPage>E169</EndPage><MedlinePgn>E165-E169</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1532/hsf.2947</ELocationID><Abstract><AbstractText Label="BACKGROUND">Coronary artery aneury... | It has been shown that endocardial endothelial cells (EECs) and coronary endothelial cells (CECs) differ in origin, development, markers, and functions. Consequently, these two cell populations play unique roles in cardiac diseases. Current studies involving isolated endothelial cells investigate cell populations consi... |
2,327,723 | Cerebrospinal fluid-contacting neurons affect the expression of endogenous neural progenitor cells and the recovery of neural function after spinal cord injury. | To explore the relationship between cerebrospinal fluid-contacting neurons (CSF-cNs) and endogenous neural progenitor cells (ENPCs) and whether CSF-cNs are involved in nerve repair after spinal cord injury (SCI).</AbstractText>Cholera toxin B-horseradish peroxidase complex (CB-HRP) and cholera toxin B conjugated with s... |
2,327,724 | Surgical treatment of a rare rosette-forming glioneuronal tumor in the pineal region. | Rosette-forming glioneuronal tumors (RGNTs) in the pineal region are rare. RGNTs have been described in the fourth ventricle, but rarely reported in other brain regions. Here, we report the radiological findings, surgical treatment, and short-term outcome of an RGNT found in the pineal region.</AbstractText>We present ... |
2,327,725 | Preoperative radiographic and clinical factors associated with the visualization of intraoperative cerebrospinal fluid during endoscopic transsphenoidal resection of pituitary adenomas. | Intraoperative visualization of cerebrospinal fluid (CSF) during endoscopic endonasal resection of skull base tumors is the most common factor contributing to the development of postoperative CSF leaks. No previous studies have solely evaluated preoperative factors contributing to intraoperative CSF visualization. The ... |
2,327,726 | Anisakis and Hysterothylacium species in Mediterranean and North-East Atlantic fishes commonly consumed in Spain: Epidemiological, molecular and morphometric discriminant analysis. | The consumption of raw fish parasitized with larval ascaridoid nematodes of the family Anisakidae can cause anisakiasis, provoking gastrointestinal and/or allergic symptomatology. The main causative agents in the Anisakis genus are the sibling species Anisakis simplex sensu stricto (s.s.) and A. pegreffii of the A. sim... |
2,327,727 | Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner. | Long-term cognitive deficits are observed after treatment of brain tumors or metastases by radiotherapy. Treatment optimization thus requires a better understanding of the effects of radiotherapy on specific brain regions, according to their sensitivity and interconnectivity. In the present study, behavioral tests supp... |
2,327,728 | Proliferation of endothelial cells in the choroid plexus of normal and hydrocephalic mice. | The choroid plexus (CP), located at the walls of the brain ventricles, produces and secretes cerebrospinal fluid (CSF). Hydrocephalus is a neurological disorder in which the CP abnormally secretes excess amounts of CSF into the ventricles. There is currently no information on the vascular dynamics of the CP in adult br... |
2,327,729 | Cognitive impairment appears progressive in the mdx mouse. | Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease caused by mutations in the DMD gene, which encodes the large cytoskeletal protein dystrophin. Approximately one-third of DMD patient's exhibit cognitive problems yet it is unknown if cognitive impairments worsen with age. The mdx mouse mo... |
2,327,730 | Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. | Gestational methylazoxymethanol acetate (MAM) treatment produces offspring with adult phenotype relevant to schizophrenia, including positive- and negative-like symptoms, cognitive deficits, dopaminergic dysfunction, structural and functional abnormalities. Here we show that adult rats prenatally treated with MAM at ge... |
2,327,731 | Volume estimation of brain ventricles using Cavalieri's principle and Atlas-based methods in Alzheimer disease: Consistency between methods. | Automatic estimations of brain ventricles are needed to assess disease progression in neurodegenerative disorders such as Alzheimer Disease (AD). The objectives of this study are to evaluate the diagnostic performances of an automated volumetric assessment tool in estimating lateral ventricle volumes in AD and to compa... |
2,327,732 | Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity. | Although advancements in cancer treatments using radiation therapy (RT) have led to improved outcomes, radiation-induced heart disease (RIHD) remains a significant source of morbidity and mortality in survivors of cancers in the chest. Currently, there are no diagnostic tests in clinical use due to a lack of understand... |
2,327,733 | Growth and cardiovascular development are repressed by florfenicol exposure in early chicken embryos. | Florfenicol (FLO) is one of the most popular antibacterial drugs used in veterinary clinics and aquaculture. The drug was found to decrease the hatchability of eggs laid by treated hens in veterinary clinics and research work. However, the pathological changes in developing embryos and their cardiovascular system and t... |
2,327,734 | Levels of caspase-1 in cerebrospinal fluid of patients with traumatic brain injury: correlation with intracranial pressure and outcome. | The objectives of this study were to evaluate levels of inflammasome-signaling proteins in serum and CSF of patients with traumatic brain injury (TBI), and to correlate these protein levels with intracranial pressure (ICP) and clinical outcomes at 6 months after injury.</AbstractText>This is a prospective and observati... |
2,327,735 | High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model. | Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates.</Abstr... |
2,327,736 | A simple and cost-effective model for ventricular catheter placement training: technical note. | External ventricular drain (EVD) placement is one of first cranial procedures neurosurgery residents are expected to perform independently. While proper training improves patient outcomes, there are few options for practicing EVD placement prior to placing the EVD in patients in a clinical setting. Proposed solutions t... |
2,327,737 | Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier. | Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological complications in the developing fetal and adult brains. In terms of pathogenesis, a critical question is how ZIKV overcomes the barriers separating the brain from the circulation and gains access to the central nervous system (CNS). De... |
2,327,738 | Membrane current evoked by mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchange in mouse heart. | The electrogenicity of mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> exchange (NCXm) had been controversial and no membrane current through it had been reported. We succeeded for the first time in recording NCXm-mediated currents using mitoplasts derived from mouse ventricle. Under conditions that K<sup>+</sup>, Cl<sup>... |
2,327,739 | Dual functions of CNS inflammation in food intake and metabolic regulation. | Western diet (WD) consumption induces chronic mild inflammation in the hypothalamus. However, metabolic consequences of increased hypothalamic inflammatory cytokines remain unclear. This research first aimed to examine whether increased proinflammatory cytokines in the brain influenced feeding or metabolism. Rats that ... |
2,327,740 | Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis. | Geissoschizine methyl ether (GM) is one of the main active ingredients responsible for ameliorating the behavioral and psychological symptoms of dementia (BPSD) in Kampo medicine yokukansan. GM is mainly metabolized into hydroxylated forms (HM-1/2). However, the brain distributions of GM and HM has not been reported in... |
2,327,741 | Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function. | The blood-cerebrospinal fluid barrier (BCSFB) is a highly dynamic transport interface that serves brain homeostasis. To date, however, understanding of its role in brain development and pathology has been hindered by the absence of a non-invasive technique for functional assessment. Here we describe a method for non-in... |
2,327,742 | Intrathecal Antibacterial and Antifungal Therapies. | Intrathecal administration of anti-infectives is indicated in central nervous system infections by multiresistant pathogens when drugs that can reach adequate cerebrospinal fluid (CSF) concentrations by systemic therapy are not available. Antibiotics that readily pass the blood-brain and blood-CSF barriers and/or that ... |
2,327,743 | Holocord Syrinx Associated with Shunt Malfunction in Tetraventricular Hydrocephalus. | We present an uncommon case of holocord, "rosary bead-like," multiloculated syringomyelia consistent with a fourth ventricle outlet obstruction in a 2-month-old infant who was previously shunted for posthemorrhagic hydrocephalus of prematurity. The shunt malfunction resulted in a syringomyelia because of the simultaneo... |
2,327,744 | Endoscopic Fenestration of Cavum Septum Pellucidum Cysts to the Third Ventricle: Technical Note. | Cavum septum pellucidum (CSP) and cavum vergae (CV) cysts are common incidental findings on imaging studies. However, they may rarely present with symptoms related to the obstruction of the foramen of Monro by the cyst leaflets. There is no consensus regarding the management of symptomatic CSP and CV cysts. We present ... |
2,327,745 | Pediatric pial arteriovenous fistula located at the bottom of the callosal sulcus presenting with intraventricular hemorrhage: a case report and literature review. | A pial arteriovenous fistula (pAVF) is a rare condition characterized by a direct connection between a cerebral artery and cerebral vein without an intervening nidus. The prognosis is poor in untreated cases with hemorrhagic manifestations, indicating that surgical treatment is desirable. We describe a successful endov... |
2,327,746 | Tuberous sclerosis complex associated intracranial lesion found by antenatal ultrasound. | Tuberous sclerosis complex (TSC) is characterized by the growth of benign tumors in the skin, brain, kidneys, lung and heart [1]. Prognosis is mostly determined by the extent of brain involvement as tumors in the brain lead to seizures, cognitive impairment and behavioral problems. Current evidence suggests anti-epilep... |
2,327,747 | Hospital-Associated Venous Thromboembolism in a Pediatric Cardiac ICU: A Multivariable Predictive Algorithm to Identify Children at High Risk. | Critically ill children with cardiac disease are at significant risk for hospital-associated venous thromboembolism, which is associated with increased morbidity, hospital length of stay, and cost. Currently, there are no widely accepted guidelines for prevention of hospital-associated venous thromboembolism in pediatr... |
2,327,748 | Mild Encephalitis/Encephalopathy with reversible splenial lesion syndrome: An unusual presentation of anti-GFAP astrocytopathy. | Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a rare recently defined antibody-mediated encephalitis. Meningo-encephalomyelitis presentation is frequent with lymphocytic pleiocytosis in the cerebro-spinal fluid and brain MRI classically demonstrates in 50% of cases, a linear perivascular enhanceme... |
2,327,749 | Multi-atlas image registration of clinical data with automated quality assessment using ventricle segmentation. | Registration is a core component of many imaging pipelines. In case of clinical scans, with lower resolution and sometimes substantial motion artifacts, registration can produce poor results. Visual assessment of registration quality in large clinical datasets is inefficient. In this work, we propose to automatically a... |
2,327,750 | Light-cardiogram, a simple technique for heart rate determination in adult zebrafish, Danio rerio. | Current techniques for heart rate determination in adult zebrafish require specialist expertise and are often invasive, technically challenging and not readily transferable to other laboratories for routine assessment. Here, we present a simple, noninvasive and inexpensive light-cardiogram technique to assess heart rat... |
2,327,751 | Trapped fourth ventricle-treatment options and the role of open posterior fenestration in the surgical management. | Trapped fourth ventricle (TFV) is a rare and difficult to treat condition. Most patients have a past inciting event (infection, IVH, trauma) and history of prior CSF diversion. The symptoms are due to the mass effect on brainstem and cerebellum. Rarely, TFV can also be associated with syrinx formation due to a dissocia... |
2,327,752 | Select Atrophied Regions in Alzheimer disease (SARA): An improved volumetric model for identifying Alzheimer disease dementia. | Volumetric biomarkers for Alzheimer disease (AD) are attractive due to their wide availability and ease of administration, but have traditionally shown lower diagnostic accuracy than measures of neuropathological contributors to AD. Our purpose was to optimize the diagnostic specificity of structural MRIs for AD using ... |
2,327,753 | Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke. | White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive impairment and vascular brain burden. Recent studies have shown that WMHs may only represent an extreme end of a diffuse pathological spectrum of white matter (WM) degeneration. The present... |
2,327,754 | Dehydroeffusol Rescues Amyloid β<sub>25-35</sub>-Induced Spatial Working Memory Deficit. | Amyloid β (Aβ) peptides produced from the amyloid precursor protein, a transmembrane protein, are neurotoxic and blocking the neurotoxicity may lead to prevention of Alzheimer's disease (AD). Here we tested whether Aβ<sub>25-35</sub>-induced cognitive decline is rescued by treatment with dehydroeffuso... |
2,327,755 | Poroelastic Mechanical Properties of the Brain Tissue of Normal Pressure Hydrocephalus Patients During Lumbar Drain Treatment Using Intrinsic Actuation MR Elastography. | Hydrocephalus (HC) is caused by accumulating cerebrospinal fluid resulting in enlarged ventricles and neurological symptoms. HC can be treated via a shunt in a subset of patients; identifying which individuals will respond through noninvasive imaging would avoid complications from unsuccessful treatments. This prelimin... |
2,327,756 | Automating in vivo cardiac diffusion tensor postprocessing with deep learning-based segmentation. | In this work we develop and validate a fully automated postprocessing framework for in vivo diffusion tensor cardiac magnetic resonance (DT-CMR) data powered by deep learning.</AbstractText>A U-Net based convolutional neural network was developed and trained to segment the heart in short-axis DT-CMR images. This was us... |
2,327,757 | Quadrigeminal arachnoid cyst with perinatal encephalocele. | Quadrigeminal arachnoid cyst (QAC) associated with encephalocele is rare; and while some treatments have been developed in recent years, no definite therapeutic approach for QAC has been established. Endoscopic treatment for arachnoid cyst is gaining popularity because it is relatively less invasive to the normal brain... |
2,327,758 | Chordoid Glioma of the Third Ventricle: A Case Report and a Treatment Strategy to This Rare Tumor. | Chordoid glioma (CG) of the third ventricle is a rare type of brain tumor. Here, we present a case, review of the literature and proposed a treatment strategy for this rare tumor. Here, A 33-years-old woman presented with the menstrual disorder and progressive obesity. Magnetic resonance imaging showed a large irregula... |
2,327,759 | Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men. | The wave condition number (WCN) is a non-dimensional number that determines the state of arterial wave reflections. WCN is equal to HR × L eff</i></sub> /PWV where HR, L eff</i></sub> , and PWV are the heart rate, effective length, and pulse wave velocity, respectively. It has been shown that a value of WCN = 0.1 ... |
2,327,760 | Experimental Activation of Endocannabinoid System Reveals Antilipotoxic Effects on Cardiac Myocytes. | Hypertension coincides with myocardial alternations in lipid (including sphingolipids) and glucose metabolism. The latest data indicate that accumulation of metabolically active lipids, especially ceramide (CER) and diacylglycerol (DAG) significantly influences intracellular signaling pathways along with inducing insul... |
2,327,761 | Left ventricle automatic segmentation in cardiac MRI using a combined CNN and U-net approach. | Cardiovascular diseases can be effectively prevented from worsening through early diagnosis. To this end, various methods have been proposed to detect the disease source by analyzing cardiac magnetic resonance images (MRI), wherein left ventricular segmentation plays an indispensable role. However, since the left ventr... |
2,327,762 | The Effect of Auditory Verbal Hallucinations on the Relationship between Spontaneous Brain Activity and intraventricular Brain Temperature in Patients with Drug-Naïve Schizophrenia. | Our recent study reported that adolescent-onset schizophrenia showed an uncoupling between intraventricular brain temperature (iBT) and local spontaneous brain activity (SBA). While auditory verbal hallucinations (AVH) are common in schizophrenia, the role of AVH in the iBT-SBA relationship is unclear. The current stud... |
2,327,763 | Clinical predictivity of thalamic sub-regional connectivity in clinically isolated syndrome: a 7-year study. | Here, we explored trajectories of sub-regional thalamic resting state (RS) functional connectivity (FC) modifications occurring in clinically isolated syndrome (CIS) patients early after their first clinical episode, and assessed their relationship with disability over 7 years. RS fMRI and clinical data were prospectiv... |
2,327,764 | Alterations of Ca<sup>2+</sup> signaling and Ca<sup>2+</sup> release sites in cultured ventricular myocytes with intact internal Ca<sup>2+</sup> storage. | Although cultured adult cardiac myocytes in combination with cell-level genetic modifications have been adopted for the study of protein function, the cellular alterations caused by the culture conditions themselves need to be clarified before we can interpret the effects of genetically altered proteins. We systematica... |
2,327,765 | Surgical treatment of hypothalamic hamartomas. | Hypothalamic hamartomas are aberrant masses, composed of abnormally distributed neurons and glia. Along endocrine and cognitive symptoms, they may cause epileptic seizures, including the specific gelastic and dacrystic seizures. Surgery is the treatment of drug-resistant hamartoma epilepsy, with associated positive res... |
2,327,766 | Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis. | The associative striatum, an established substrate in psychosis, receives widespread glutamatergic projections. We sought to see if glutamatergic indices are altered between early psychosis patients with and without a history of cannabis use and characterise the relationship to grey matter. 92 participants were scanned... |
2,327,767 | A case report of Fontan procedure-related hepatocellular carcinoma: pure laparoscopic approach by low and stable pneumoperitoneum.<Pagination><StartPage>80</StartPage><MedlinePgn>80</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">80</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12893-020-... | The Fontan procedure has become the standard operation for patients with single ventricle physiology. Due to cardiac hypokinesis and high central venous pressure, laparoscopic approach, especially in hepatectomy, was considered as controversial after the Fontan procedure. We presented a case of hepatocellular carcinoma... |
2,327,768 | Hemifacial Spasm Associated with Compression of the Facial Colliculus by a Choroid Plexus Papilloma of the Fourth Ventricle. | Hemifacial spasm is an involuntary condition that involves muscles innervated by the ipsilateral facial nerve. There are secondary causes of hemifacial spasm that can produce a typical presentation of symptoms. Extrinsic compression of the facial colliculus at the floor of the fourth ventricle is responsible for <0.... |
2,327,769 | Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules. | Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough nut to crack for most of the antigens and chemical substances. The presence of tight junctions plays a remarkable role in defending the brain from antigenic and pathogenic attacks. BBB constitutes a diverse assemblage of multiple... |
2,327,770 | Brain-synthesized oestrogens regulate cortical migration in a sexually divergent manner. | Oestrogens play an important role in brain development where they have been implicated in controlling various cellular processes. Several lines of evidence have been presented showing that oestrogens can be synthesized locally within the brain. Studies have demonstrated that aromatase, the enzyme responsible for the co... |
2,327,771 | Intraventricular Medium B Treatment Benefits an Ischemic Stroke Rodent Model via Enhancement of Neurogenesis and Anti-apoptosis. | Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pro... |
2,327,772 | Wnt-PLC-IP<sub>3</sub>-Connexin-Ca<sup>2+</sup> axis maintains ependymal motile cilia in zebrafish spinal cord. | Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of the spinal cord (SC). How ependymal motile cilia are maintained remains largely unexplored. Here we show that zebrafish embryos deficient in Wnt signaling have defective motile cilia, yet harbor ... |
2,327,773 | Evaluation of the development of the posterior fossa in normal Chinese fetuses by using magnetic resonance imaging. | The posterior fossa is an important brain structure containing the cerebellum, cerebral ventricle, and cistern. Early evaluation of the cerebellar structure and function may be valuable for early detection of fetal deformities. At present, no normal value for the fetal posterior fossa has been established yet. This stu... |
2,327,774 | Hydrocephalus in Guillain barre syndrome: A case report and review of the literature. | Guillian-Barré syndrome (GBS) is a devastating autoimmune disorder characterized by progressive ascending weakness, areflexia with or without autonomic and sensory disturbances. Hydrocephalus is a rare but well-documented complication in patients with GBS. However, due to the rarity of this condition, no treatment... |
2,327,775 | The Caudate Nucleus: Its Connections, Surgical Implications, and Related Complications. | The caudate nucleus is a C-shaped structure that is located in the center of the brain and is divided into 3 parts: the head, body, and tail.</AbstractText>We detail the anatomic connections, relationships with other basal ganglia structures, and clinical implications of injury to the caudate nucleus.</AbstractText>Ana... |
2,327,776 | Cardiac toxicity of acrolein exposure in embryonic zebrafish (Danio rerio). | Acrolein is a widely distributed pollutant produced from various sources such as industrial waste, organic combustion, and power plant emissions. It is also intentionally released into irrigation canals to control invasive aquatic plants. Zebrafish (Danio rerio) has a good reputation for being an attractive model organ... |
2,327,777 | Ventricular volume, white matter alterations and outcome of major depression and their relationship to endocrine parameters - A pilot study. | Brain morphology and its relation to endocrine parameters were examined, in order to determine the link of these parameters to treatment outcome to psychopharmacological treatment in depressed patients.</AbstractText>We examined the potentially predictive value of Magnetic Resonance Imaging (MRI) parameters related to ... |
2,327,778 | Altered D2 receptor and transcription factor EB expression in offspring of aggressive male rats, along with having depressive and anxiety-like behaviors. | In this study we have evaluated the behavioral mood variations, and expression of DR-D2 and TFEB genes in the amygdala and PFC of aggressive male rats' offspring.</AbstractText>Anxiety and depression-like behaviors were observed, but intra-ventricle injection of DR-D2 antagonist (Sulpiride) has shown to be efficient in... |
2,327,779 | Evaluation of cell transplant-mediated attenuation of diffuse injury in experimental autoimmune encephalomyelitis using onVDMP CEST MRI. | The development and translation of cell therapies have been hindered by an inability to predict and evaluate their efficacy after transplantation. Using an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis (MS), we studied attenuation of the diffuse injury characteristic of EAE and MS by... |
2,327,780 | Contributory Role of Positron Emission Tomography in a Left Ventricular Assist Device Recipient at the Time of COVID-19 Pandemic.<Pagination><StartPage>599</StartPage><EndPage>602</EndPage><MedlinePgn>599-602</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MAT.0000000000001176</ELocationID><Abst... | In this study, We report on the use of fluorine 18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) scan examinations for detecting potential COVID-19 respiratory syndrome in asymptomatic left ventricular assist device (LVAD) recipients. Thus, extreme caution and thoughtful approaches should be taken for a... |
2,327,781 | Chemotherapy-related cognitive impairment in patients with breast cancer based on MRS and DTI analysis. | The purpose of this study is to investigate chemotherapy-related cognitive impairment (CRCI) in breast cancer patients, analyze absolute concentration and structural changes of metabolites in different brain regions by multimodal neuroimaging technology, and explore correlation between them. Breast cancer patients with... |
2,327,782 | [Purely endoscopic supracerebellar infratentorial approach for epidermoid cyst in third ventricle]. | The epidermoid cyst as a pineal region tumor is an infrequent pathology and with few descriptions in literature. Its prevalence in the third ventricle is 0,0042% of all intracranial tumors. To achieve a complete exéresis we used an endoscopic supracerebellar-infratentorial approach, surgical technique for pineal r... |
2,327,783 | Obstructive hydrocephalus due to aqueductal stenosis from developmental venous anomaly draining bilateral medial thalami: a case report. | Hydrocephalus is a pathological buildup of cerebrospinal fluid within the ventricles leading to ventricular enlargement out of proportion to sulci and subarachnoid spaces. Developmental venous anomaly is a common benign and usually asymptomatic congenital cerebrovascular malformation. Hydrocephalus caused by aqueductal... |
2,327,784 | Coincidental retinal dysplasia in patients presenting with pseudohypopyon: a series of two cases. | Clinical diagnosis is always challenging in cases with atypical presentation. Herein, we present two cases which masqueraded as ocular infection/inflammation on presentation, were clinically suspicious for retinoblastoma, and histopathology revealed the diagnosis of retinal dysplasia. Case 1 had left corneal perforatio... |
2,327,785 | Characterization of Kisspeptin Neurons in the Human Rostral Hypothalamus. | Kisspeptin (KP) neurons in the rostral periventricular region of the 3rd ventricle (RP3V) of female rodents mediate positive estrogen feedback to gonadotropin-releasing hormone neurons and, thus, play a fundamental role in the mid-cycle luteinizing hormone (LH) surge. The RP3V is sexually dimorphic, and male rodents wi... |
2,327,786 | The CSF-contacting nucleus regulates learning and memory through synaptic connections with the hippocampus. | The cerebrospinal fluid (CSF)-contacting nucleus is a special nucleus. To study the mechanism of the CSF-contacting nucleus in learning and memory, we used classic retrograde tracing methods to observe the synaptic connections between the CSF-contacting nucleus and the hippocampus. By injecting cholera toxin B subunit ... |
2,327,787 | The selective 5-HT<sub>2A</sub> receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [<sup>3</sup>H]25CN-NBOH. | The remarkable effects exhibited by classical psychedelics in recent clinical trials have spawned considerable interest in 5-HT<sub>2A</sub> receptor (5-HT<sub>2A</sub>R) activation as a treatment strategy for several psychiatric/cognitive disorders. In this study we have continued our development of 25CN-NBOH, one of ... |
2,327,788 | [Value of computer tomographic characteristics of the ventricles of the brain and cerebral hemocirculation in forensic medical examination of mild traumatic brain injury]. | Aim of this study is to determine the changes in the parameters of the ventricles of the brain and cerebral hemodynamics to improve the diagnosis of mild traumatic brain injury. A decrease in the parameters of the lateral ventricles in combination with diffuse cerebral hypoperfusion was found. Focal disorders of cerebr... |
2,327,789 | In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors. | Imagining ways to prevent or treat glioblastoma (GBM) has been hindered by a lack of understanding of its pathogenesis. Although overexpression of platelet derived growth factor with two A-chains (PDGF-AA) may be an early event, critical details of the core biology of GBM are lacking. For example, existing PDGF-driven ... |
2,327,790 | Connection Input Mapping and 3D Reconstruction of the Brainstem and Spinal Cord Projections to the CSF-Contacting Nucleus. | To investigate whether the CSF-contacting nucleus receives brainstem and spinal cord projections and to understand the functional significance of these connections.</AbstractText>The retrograde tracer cholera toxin B subunit (CB) was injected into the CSF-contacting nucleus in Sprague-Dawley rats according the previous... |
2,327,791 | The Assessment of Geometric Reliability of Conventional Trajectory of Ventriculostomy in a Three Dimensional Virtual Model and Proposal of a New Trajectory. | Ventriculostomy is a common neurosurgery procedure performed for many purposes. Kocher's point is most often used as the ventriculostomy entry point. But the accuracy of a cannula's trajectory into the ventricles from entry at Kocher's point is controversial. In this paper we attempt to evaluate the accuracy of the con... |
2,327,792 | Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting. | To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprint... |
2,327,793 | Biventricular hydrocephalus secondary to aqueductal developmental venous anomaly. | Developmental venous anomaly (DVA) is the most common type of intracranial vascular malformation. These lesions are benign and are considered to be non-pathological variants of normal deep parenchymal veins. Although most of them are asymptomatic, a small subset of them located in aqueductal region have been reported t... |
2,327,794 | Changes in the Paradigm of Traditional Exercise in Obesity Therapy and Application of a New Exercise Modality: A Narrative Review Article. | Obesity is recognized as an important global health problem that increases the risk of all-cause death. It is a major risk factor for various cardiovascular and metabolic diseases.</AbstractText>We conducted this review through searching the related literature plus internet links.</AbstractText>Recently, many researche... |
2,327,795 | Progressive multifocal leukoencephalopathy in a lung transplant recipient presenting with memory impairment: Case report and literature review. | Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by JC virus (JCV). The disease occurs in the setting of significant immunocompromise and has now been reported in many different settings, although only very rarely after lung transplantation. The morta... |
2,327,796 | Sequelae of Premature Birth in Young Adults : Incidental Findings on Routine Brain MRI. | Qualitative studies about the abnormalities appreciated on routine magnetic resonance imaging (MRI) sequences in prematurely born adults are lacking. This article aimed at filling this knowledge gap by (1) qualitatively describing routine imaging findings in prematurely born adults, (2) evaluating measures fo... |
2,327,797 | Ependymal Vps35 Promotes Ependymal Cell Differentiation and Survival, Suppresses Microglial Activation, and Prevents Neonatal Hydrocephalus. | Hydrocephalus is a pathologic condition associated with various brain diseases, including Alzheimer's disease (AD). Dysfunctional ependymal cells (EpCs) are believed to contribute to the development of hydrocephalus. It is thus of interest to investigate EpCs' development and function. Here, we report that vacuolar pro... |
2,327,798 | Intracranial Effects of Microgravity: A Prospective Longitudinal MRI Study. | Background Astronauts on long-duration spaceflight missions may develop changes in ocular structure and function, which can persist for years after the return to normal gravity. Chronic exposure to elevated intracranial pressure during spaceflight is hypothesized to be a contributing factor, however, the etiologic caus... |
2,327,799 | Deep Learning Single-Frame and Multiframe Super-Resolution for Cardiac MRI. | Background Cardiac MRI is limited by long acquisition times, yet faster acquisition of smaller-matrix images reduces spatial detail. Deep learning (DL) might enable both faster acquisition and higher spatial detail via super-resolution. Purpose To explore the feasibility of using DL to enhance spatial detail from small... |
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