Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
4,900 | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | Effects of the calcineurin inhibitor FK506, the platelet-activating factor (PAF) antagonist, and free radical scavenger Ginkgo biloba extract, EGb 761, and their combination on reperfusion-induced ventricular fibrillation (VF), ventricular tachycardia (VT), and recovery of cardiac function were studied after 30 min of ... |
4,901 | Modulation of ventricular fibrillation in the isolated heart: the role of slow calcium channel activity under continuous perfusion. | The individual activities of sodium versus calcium channels in the initiation and maintenance of ventricular fibrillation (VF) have not been fully elucidated. Therefore we studied in isolated heart under nonischemic conditions (a) VF characteristics in untreated hearts, (b) initiation and maintenance of VF during atten... |
4,902 | Antidysrhythmics. Emergent. | The emergent treatment of dysrhythmias in the ED continues to evolve. Classic medications such as bretylium and lidocaine are given with newer drugs like amiodarone, ibutilide, and sotalol. Studies in progress will examine their efficacy in the ED. The emergency physician must keep abreast of the growing body of litera... |
4,903 | Role of structural barriers in the mechanism of alternans-induced reentry. | Previously, using an animal model of T-wave alternans in structurally normal myocardium, we demonstrated that repolarization can alternate with opposite phase between neighboring myocytes (ie, discordant alternans), causing spatial dispersions of repolarization that form the substrate for functional block and reentrant... |
4,904 | Ventricular fibrillation: how do we stop the waves from breaking? | Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution... |
4,905 | Cardiac arrhythmias and stroke: increased risk in men with high frequency of atrial ectopic beats. | With the exception of atrial fibrillation (AF), little scientific attention has been given the associations between cardiac arrhythmias and incidence of stroke. We sought to study whether atrial and ventricular arrhythmias assessed during a 24-hour ambulatory ECG registration are associated with incidence of stroke.</A... |
4,906 | Electrophysiological deterioration during long-duration ventricular fibrillation. | Probability of survival from sudden cardiac arrest caused by ventricular fibrillation (VF) decreases rapidly with fibrillation duration. We hypothesized that cellular ischemia/fibrillation-induced electrophysiological deterioration underlies decreased survival.</AbstractText>We determined fibrillation monophasic action... |
4,907 | Exogenous GSH protection during hypoxia-reoxygenation of the isolated rat heart: impact of hypoxia duration. | The objective of this study was to determine the interaction between duration of myocardial hypoxia and presence of exogenous glutathione (GSH) on functional recovery upon subsequent reoxygenation. Isolated perfused rat hearts were subjected to 20, 30, 40, or 50 min hypoxia (HYP), which resulted in a progressive declin... |
4,908 | Definitive palliation with cavopulmonary or aortopulmonary shunts for adults with single ventricle physiology. | To compare the relative merits of cavopulmonary or aortopulmonary shunts, or both, as definitive non-Fontan palliations for patients with single ventricle physiology.</AbstractText>Clinical data, ECG, echocardiographic data, surgical records, and available postmortem material were reviewed in all patients with single v... |
4,909 | Ventricular pre-excitation in the general population: a study on the mode of presentation and clinical course. | To describe the mode of presentation and the clinical course of patients with ventricular pre-excitation (Wolff-Parkinson-White (WPW) syndrome), with special emphasis on asymptomatic cases in the general population.</AbstractText>Over an eight year period (1990-97) a prospective population based survey of cases with WP... |
4,910 | Cardiac Na(+) channel dysfunction in Brugada syndrome is aggravated by beta(1)-subunit. | Mutations in the gene encoding the human cardiac Na(+) channel alpha-subunit (hH1) are responsible for chromosome 3-linked congenital long-QT syndrome (LQT3) and idiopathic ventricular fibrillation (IVF). An auxiliary beta(1)-subunit, widely expressed in excitable tissues, shifts the voltage dependence of steady-state ... |
4,911 | Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. | Whether the dietary intake of long-chain n-3 polyunsaturated fatty acids (PUFAs) from seafood reduces the risk of ischemic heart disease remains a source of controversy, in part because studies have yielded inconsistent findings. Results from experimental studies in animals suggest that recent dietary intake of long-ch... |
4,912 | Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids. | In animal feeding studies, and probably in humans, n-3 polyunsaturated fatty acids (PUFAs) prevent fatal ischemia-induced cardiac arrhythmias. We showed that n-3 PUFAs also prevented such arrhythmias in surgically prepared, conscious, exercising dogs. The mechanism of the antiarrhythmic action of n-3 PUFAs has been stu... |
4,913 | Response to repeated equal doses of epinephrine during cardiopulmonary resuscitation in dogs. | Advanced cardiac life support (ACLS) guidelines recommend a 3- to 5-minute interval between repeated doses of epinephrine. This recommendation does not take into account the dose of epinephrine used, and only very limited data exist regarding the hemodynamic responses to repeated "high" doses of epinephrine. The object... |
4,914 | Dispersion of ventricular repolarization and ventricular fibrillation in left ventricular hypertrophy: influence of selective potassium channel blockers. | This study tested the hypothesis that combination ion channel blockers of the transient outward current (I(to)) and the rapid component of the delayed rectifying current (I(Kr)) would produce greater prolongation of the ventricular action potential duration (APD) and increased dispersion of the APD in hypertrophied hea... |
4,915 | Quality of life in atrial fibrillation. | In patients with atrial fibrillation (AF), the restoration and maintenance of sinus rhythm is the primary therapeutic goal. Once sinus rhythm is maintained, physiological rate control is restored, and left ventricular ejection fraction, cardiac output, and exercise capacity are increased. This improved cardiovascular p... |
4,916 | Design and preliminary data of the Metrix Atrioverter expanded indication trial. | The Metrixtrade mark Atrioverter Expanded Indication Trial evaluates the safety and efficacy of an implantable atrial defibrillator in patients with symptomatic, recurrent and drug refractory atrial fibrillation who also have structural heart disease. In this ongoing multicenter study, all patients are anticoagulated a... |
4,917 | Clinical experience with implantable atrial and combined atrioventricular defibrillators. | The high prevalence of atrial fibrillation (AF) and its clinical complications, the poor efficacy of medical therapy for preventing recurrences, and dissatisfaction with alternative modes of therapy stimulated interest in implantable atrial and combined atrioventricular defibrillators. In a multicenter study, the safet... |
4,918 | Combining antiarrhythmic drugs and implantable devices therapy: benefits and outcome. | At least 50% of patients who received an ICD have been treated with antiarrhythmic drugs (AAD). The potential indications for combining antiarrhythmic drugs and ICD are generally the following: reduction of the number of episodes of ventricular tachycardia or ventricular fibrillation and therefore of the number of shoc... |
4,919 | The role of EP-guided therapy in ventricular arrhythmias: beta-blockers, sotalol, and ICD's. | Arrhythmic death can be reduced by antiarrhythmic drugs to a range of 24%. Electrophysiologic study by testing noninducibility of ventricular arrhythmia represents the classic method for evaluating the effectiveness of drug therapy. Several clinical studies have shown thaat sotalol suppresses VT induction and prevents ... |
4,920 | Amiodarone: maximising survival benefit with empiric or guided therapy. | Review of available data suggests that serial drug testing in patients with a history of sustained ventricular tachyarrhythmias using various antiarrhythmic drugs including amiodarone is able to identify subgroups with favorable and unfavorable outcome (patient groups with suppression vs. no suppression of inducibility... |
4,921 | Acute coronary syndrome and cardiac arrest: using simulation to assess resident performance and program outcomes. | Simulation training has emerged as an effective method of educating residents in cardiac emergencies. Few studies have used emergency simulation scenarios as an outcome measure to identify training deficiencies within residency programs.</AbstractText>The purpose of this study was to evaluate postgraduate year-1 (PGY-1... |
4,922 | Heart failure in acute ischemic stroke. | Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. Due to the aging of the population it has become a growing public health problem in recent decades. Diagnosis of HF is clinical and ... |
4,923 | Effect of catheter ablation on the left ventricular mass index and other echocardiograph parameters in atrial fibrillation patients: comparison with antiarrhythmic drug treatment. | Catheter ablation (CA) is reported to improve left ventricular (LV) function in patients with atrial fibrillation (AF). This study compared the effects of CA and antiarrhythmic drug treatment (AT) on LV remodeling and other echocardiography parameters in AF.</AbstractText>We performed a non-randomized prospective study... |
4,924 | [Ventricular arrhythmias, sudden death and heart failure]. | Despite therapeutic advances, the mortality rate associated with congestive heart failure remains as high as 20% per year. Among patients with severe left ventricular dysfunction, more than 60% of deaths result from ventricular tachycardia or fibrillation, 20% from bradyarrhythmias (including advanced atrio-ventricular... |
4,925 | [Sudden cardiac death, a major scientific challenge]. | Sudden death is responsible for 350,000 deaths each year in Europe, or 1000 deaths each day, equivalent to the combined mortality from the most lethal cancers (breast, lung and colorectal). Unfortunately, sudden death is widely considered to be "natural", being due to unknown but critical cardiac disorders leading to s... |
4,926 | A case report of atrial fibrillation potentially induced by hydroxycut: a multicomponent dietary weight loss supplement devoid of sympathomimetic amines. | Multicomponent dietary weight loss supplements comprise the single largest segment of herbal preparations available to the public. As a result of limited de novo regulatory oversight, supplement-related adverse events are underreported secondary to the lack of adequate pharmacodynamic, pharmacokinetic, and clinical dat... |
4,927 | Survival of a refractory ventricular fibrillation by cooperative treatments. | In the case of acute myocardial infarction (AMI), prompt and appropriate initial treatment is essential for increasing the rate of survival and early reperfusion is a main determinant factor for long-term prognosis. The survival of a patient with refractory ventricular fibrillation was made possible by cooperative emer... |
4,928 | Embolized Amplatzer septal occluder device presenting with ventricular fibrillation. | The Amplatzer septal occluder device is used with high success and low-complication rate. Device embolization occurs in around 0.3-0.55% of cases. We report the case of a 44-year-old man with ventricular fibrillation (VF) due to embolization of Amplatzer septal occluder into the right ventricle, 1 h after the successfu... |
4,929 | Lesson of the month (1). Myotonic dystrophy and out-of-hospital arrest. | Myotonic dystrophy (MD) is an autosomal dominant disorder which affects both smooth and skeletal muscles. The incidence is approximately 1 in 8,000 births. It is the most common muscular dystrophy to manifest in adulthood, and the second most common skeletal muscle disorder after Duchenne MD. Cardiac rhythm disturbance... |
4,930 | [The use of hypothermia in intensive therapy]. | The authors discuss the usefulness of therapeutic hypothermia for neuroprotection in patients with hypoxic cerebral damage. Although first reports on this method were published more than 50 years ago, it gained wider popularity at the end of 20th century. This popularity was related to the fact that deep hypothermia (b... |
4,931 | [Hurst index based analysis of ventricular tachycardia and ventricular fibrillation]. | In our laboratory, the normal ECG signal, the ECG signals of ventricular tachycardia (VT) and of ventricular fibrillation (VF) are studied with the use of Hurst index value. The Hurst index values of the normal ECG signal, VT, VF are calculated separately. There exist obvious differences among the Hurst values of the t... |
4,932 | [Doubts of the cardiologist regarding an electrocardiogram presenting QRS V1-V2 complexes with positive terminal wave and ST segment elevation. Consensus Conference promoted by the Italian Cardiology Society]. | When an ECG shows (or is suspicious for) a Brugada pattern, i.e., the association of a positive terminal deflection and ST segment elevation in the right precordial leads, the cardiologist often faces several problems. Three important questions are raised by this ECG pattern: (1) is this really a Brugada ECG pattern? (... |
4,933 | Statins Do Not Reduce Atrial Fibrillation After Cardiac Valvular Surgery: A Single Centre Observational Study. | INTRODUCTION: Statins may theoretically reduce postoperative atrial fibrillation (AF) in patients after cardiac valvular surgery due to preservation of endothelial function and anti-ischaemic, anti-inflammatory and anti-remodelling effects. METHODS: Two hundred seventy-two patients who underwent cardiac workup and subs... |
4,934 | Influence of preoperative serum N-terminal pro-brain type natriuretic peptide on the postoperative outcome and survival rates of coronary artery bypass patients. | The N-terminal fragment of pro-brain type natriuretic peptide (NT-proBNP) is an established biomarker for cardiac failure.</AbstractText>To determine the influence of preoperative serum NT-proBNP on postoperative outcome and mid-term survival in patients undergoing coronary artery bypass grafting (CABG).</AbstractText>... |
4,935 | Use of digoxin for heart failure and atrial fibrillation in elderly patients. | Digoxin has been reported to improve symptoms and reduce hospitalization in patients with heart failure as well as to control rapid ventricular rate in patients with atrial fibrillation. Both of these are high-prevalence diseases in the elderly, and yet studies have indicated that digoxin may not be used appropriately ... |
4,936 | [Accidental hypothermia]. | Accidental hypothermia is an infrequent and under-diagnosed pathology, which causes fatalities every year. Its management requires thermometers to measure core temperature. An esophageal probe may be used in a hospital situation, although in moderate hypothermia victims epitympanic measurement is sufficient. Initial ma... |
4,937 | Metabolic syndrome does not impose greater atrial fibrillation risk in elderly hypertensive patients. | Metabolic syndrome (MS) increases the risk of atrial fibrillation (AF). It is not clear if MS imposes a greater risk of AF in elderly hypertensive patients.</AbstractText>The data were gathered from surveys of 3,775 patients participating in the LIFE survey from November 2005 to July 2006. From this database there were... |
4,938 | Cardiac gene expression profiling - the quest for an atrium-specific biomarker. | Biomarkers are gaining increasing interest to predict risk but also to aid in diagnostics. Tissue-specific biomarkers are of utmost importance to detect diseases of respective organs. As of yet there are no atrium-specific biomarkers for risk stratification of atrial disease, such as atrial fibrillation. Bioinformatics... |
4,939 | Long QT syndrome provoked by induction of general anesthesia -A case report-. | Long QT syndrome (LQTS) is an arrhythmogenic cardiovascular disorder resulting from mutations in cardiac ion channels. LQTS is characterized by prolonged ventricular repolarization and frequently manifests itself as QT interval prolongation on the electrocardiogram (ECG). A variety of commonly prescribed anesthetic dru... |
4,940 | Right ventricular outflow tract pacing: an alternative, safe, and effective pacing site. | The right ventricular apex (RVA) has traditionally been preferred for the insertion of permanent cardiac pacemaker leads because of vast experience with their use, their ease of implantation, and the stability of passive fixation leads in the RVA trabeculae. However, prolonged RVA pacing is associated with progressive ... |
4,941 | Prevalence of early postoperative arrhythmias in children with delayed open-heart surgery for severe congenital heart disease.<Pagination><StartPage>386</StartPage><EndPage>391</EndPage><MedlinePgn>386-91</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">BACKGROUND; Our aim was to determine the incide... | In spite of considerable success in the study of basic pathogenetic mechanisms of arrhythmias development in patients without diabetes mellitus 2 type (DM), the problem of impact of DM on disorders of the cardiac rhythm of patients with acute myocardial infarction is still not resolved. Disorders of the cardiac rhythm ... |
4,942 | The effect of early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome. | To evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or nonsustained ventricular tachycardia (NSVT) after acute coronary syndrome (ACS) (ST-elevation myocardial infarction [STEMI], non-STEMI, and unstable angina pectoris).</AbstractText>Provided that early and i... |
4,943 | AVE4454B--a novel sodium-hydrogen exchanger isoform-1 inhibitor--compared less effective than cariporide for resuscitation from cardiac arrest. | We compared the efficacy of the novel sodium-hydrogen exchanger (NHE-1) inhibitor AVE4454B with cariporide for resuscitation from ventricular fibrillation (VF) assessing the effects on left ventricular myocardial distensibility during chest compression, myocardial function after the return of spontaneous circulation, a... |
4,944 | On the mechanism of antifibrillatory effect of afobazole. | Effect of afobazole on the threshold of electrical fibrillation of the heart was studied on anesthetized rats with intact myocardium. It was shown that the drug considerably increased the threshold of electrical fibrillation of the heart, being not inferior to reference class I antiarrhythmic drugs (lidocaine and proca... |
4,945 | The effects of iron deficiency anemia on p wave duration and dispersion. | The association between P wave dispersion and iron deficiency anemia has not been documented in the literature. In this study, we evaluated P wave dispersion in patients with iron deficiency anemia and the possible relationships between P wave dispersion and other echocardiographic parameters.</AbstractText>The iron st... |
4,946 | Mortality rates and modes of death in heart failure patients with reduced versus preserved systolic function. | There are conflicting reports regarding the characteristics and mortality rates of heart failure patients with preserved (HFPSF) vs. reduced systolic left ventricular function (SHF).</AbstractText>We evaluated the clinical profiles, mortality rates and modes of death in 481 consecutive symptomatic heart failure patient... |
4,947 | Heart failure patients selection for cardiac resynchronization therapy. | Cardiac resynchronization therapy (CRT) is an established treatment for refractory chronic heart failure (CHF) patients with ventricular dyssynchrony. The patient selection for this therapy remains the basis for response improvement. Various parameters, methods and technology for identification of appropriate patient a... |
4,948 | Development of an ovine model of pediatric complete heart block. | Complete heart block is a significant clinical problem that can limit the quality of life in affected children. To understand the pathophysiology of this condition and provide for development of novel therapies, we sought to establish a large animal model of permanent, pacemaker-dependent atrioventricular block (AVB) t... |
4,949 | General anaesthesia for insertion of an automated implantable cardioverter defibrillator in a child with Brugada and autism. | A 14-year-old autistic boy presented with acute gastroenteritis and hypotension. The electrocardiogram showed a ventricular fibrillation rhythm - he went into cardiorespiratory arrest and was immediately resuscitated. On investigation, the electrocardiogram showed a partial right bundle branch block with a "coved" patt... |
4,950 | The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials. | KCNQ1 is responsible for the pore-forming subunit of channels that mediate the cardiac 'IKs' potassium channel current. The S140G KCNQ1 gain-of-function mutation is responsible for a form of heritable atrial fibrillation. Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G K... |
4,951 | Omega-3 fatty acids and atorvastatin suppress ventricular fibrillation inducibility in hypertriglyceridemic rat hearts: implication of intracellular coupling protein, connexin-43. | Omega-3 fatty acids (omega-3 FA) and statins exhibit besides lipid-lowering effects the antiarrhythmic ability in clinic, while definite mechanisms are not yet elucidated. Our goal was to examine whether these compounds can modulate inducibility of hypertriglyceridemic (HTG) rat heart to ventricular fibrillation (VF) a... |
4,952 | [Multiple organ damage in patients dying from acute decompensated heart failure]. | To detect the occurring and developing patterns of multiple organ damage in patients dying from acute decompensated heart failure (ADHF).</AbstractText>The clinical data of 30 hospitalized patients of ADHF were analyzed. The dying causes included renal, hepatic, respiratory dysfunctions, infection and anemia. All patie... |
4,953 | Genetic testing of patients with long QT syndrome. | Congenital long QT syndrome is mainly caused by mutations in the KCNQ1, KCNH2 and SCN5A genes. The aim of this study was to investigate the prevalence of mutations in these three genes in patients with long QT syndrome or idiopathic ventricular fibrillation seen at our center. The study included nine patients with long... |
4,954 | [A comparative study on the efficacy and safety of intravenous esmolol, amiodarone and diltiazem for controlling rapid ventricular rate of patients with atrial fibrillation during anesthesia period]. | To evaluate the efficacy and safety of intravenous esmolol, amiodarone and diltiazem for controlling rapid ventricular rate in patients with atrial fibrillation (AF) during anesthesia period.</AbstractText>Ninety AF patients with rapid atrial ventricular rate (≥ 120 beats/min) in anesthesia period were randomly ... |
4,955 | [Association between diastolic dysfunction evaluated by left ventricular flow propagation velocity and outcome in patients with hypertrophic cardiomyopathy]. | Left ventricular diastolic dysfunction is common in cardiovascular diseases. Hypertrophic cardiomyopathy(HCM) is a typical disease with diastolic dysfunction. We analyzed the association between the left ventricular flow propagation velocity (FPV), quantified by color M-mode Doppler and as an indicator for diastolic dy... |
4,956 | [Safety and efficacy of intraoperative defibrillation threshold measured by defibrillation safety margin in 52 patients with implantable cardioverter defibrillator]. | To observe the safety and efficacy of implantable cardioverter defibrillator (ICD) intraoperative defibrillation threshold (DFT) measured by defibrillation safety margin (DSM).</AbstractText>Fifty-two patients underwent ICD implantation were enrolled in this study (25 single chamber ICD, 23 double chamber ICD, 4 three ... |
4,957 | [Association between electrocardiogram characteristics and long-term outcome in patients with idiopathic ventricular fibrillation]. | To explore the association between clinical and ECG characteristics and prognoses in patients with idiopathic ventricular fibrillation (VF).</AbstractText>We reviewed the data from 21 VF patients [male 47.6%, mean age (38.5 ± 19.0) years] with first event of VF, all patients were resuscitated after cardiac arrest ... |
4,958 | [Clinical analyses of cardiovascular operations in patients with severe dilated left ventricle]. | To explore the perioperative features of surgical treatment in valvular patients with severe dilated left ventricle and investigate the structural changes of left ventricle and its correlation with cardiac functions.</AbstractText>A total of 126 patients with severe dilated left ventricle underwent mitral valve and/or ... |
4,959 | Sudden cause of cardiac death-be aware of me: a case report and short review on brugada syndrome. | Introduction. Brugada syndrome accounts for about 4% of sudden cardiac deaths (SCD). It is characterized by an ST-segment elevation in the right precordial electrocardiogram (EKG) leads. Case Presentation. We describe a 39-year-old healthy Caucasian man who was admitted to the intensive care unit after being cardiovert... |
4,960 | Sudden death in a patient with Noonan syndrome. | We report here the case of a 27-year-old woman with Noonan syndrome presenting with ventricular fibrillation. After successful defibrillation, echocardiography revealed hypertrophic cardiomyopathy associated with left ventricular outflow tract obstruction. Normal echocardiographic cardiac structure and function were re... |
4,961 | [The microvolt T-wave alternans test]. | Several clinical parameters and noninvasive tests have been developed to identify patients under the risk for sudden cardiac death (SCD). The microvolt T-wave alternans (MTWA) test is a noninvasive diagnostic method based on the measurement of subtle (microvolt) beat-to-beat alternation of the T-wave on the surface ele... |
4,962 | Ruptured sinus of Valsalva aneurysm associated with aortic regurgitation and severe myocardial ischemia. | Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly either presenting as a congenital heart disease or occurring secondary to cardiac surgical interventions. A 19-year-old male patient presented with chest pain and shortness of breath. On auscultation, a grade 4/6 early diastolic murmur was heard over the left l... |
4,963 | [Levosimendan and dobutamine have a similar profile for potential risk for cardiac arrhythmias during 24-hour infusion in patients with acute decompensated heart failure]. | Unlike traditional inotropic agents, levosimendan is thought to have a lower potential to induce arrhythmias because it does not increase intracellular calcium levels and myocardial oxygen consumption. We compared the potential effect of levosimendan and dobutamine to induce cardiac arrhythmias in patients with decompe... |
4,964 | Alternative stable scroll waves and conversion of autowave turbulence. | Rotating spiral and scroll waves (vortices) are investigated in the FitzHugh-Nagumo model of excitable media. The focus is on a parameter region in which there exists bistability between alternative stable vortices with distinct periods. Response functions are used to predict the filament tension of the alternative scr... |
4,965 | First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model. | There are few safe antiarrhythmics for ischemic heart disease. Whereas ranolazine is a promising late INa blocker with antiarrhythmic effects, and devoid of pro-arrhythmic properties, there are no direct comparisons between ranolazine and other antiarrhythmic agents in an ischemia/reperfusion setting. HYPOTHESIS AND ME... |
4,966 | A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx. | A new triterpene, 21-O-senecioyl-R(1)-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on... |
4,967 | Quinidine depresses the transmural electrical heterogeneity of transient outward potassium current of the right ventricular outflow tract free wall. | BACKGROUND#ENTITYSTARTX02014;: Electrical heterogeneity of the right ventricular outflow tract (RVOT) is regarded as one of the main electrophysiological substrates for Brugada syndrome. Recently quinidine has shown efficacy in patients with Brugada syndrome due to its ability to inhibit potassium current especially 4-... |
4,968 | Anesthetic management of a patient with deteriorated cardiac function following cardiopulmonary resuscitation. | A 73-year-old woman suffering from an abdominal aortic aneurysm (AAA), unstable angina, and low cardiac function (32% of ejection fraction) was scheduled for abdominal aortic replacement and coronary artery bypass grafting. However, before the scheduled operation the patient fell into cardiopulmonary arrest with ventri... |
4,969 | Na+ channel distribution and electrophysiological heterogeneities in guinea pig ventricular wall. | We sought to explore the distribution pattern of Na(+) channels across ventricular wall, and to determine its functional correlates, in the guinea pig heart. Voltage-dependent Na(+) channel (Na(v)) protein expression levels were measured in transmural samples of ventricular tissue by Western blotting. Isolated, perfuse... |
4,970 | Real-time electrogram analysis for monitoring coronary blood flow during human ventricular fibrillation: implications for CPR. | Effective chest compressions during prolonged ventricular fibrillation (VF) have been shown to increase the chances of successful defibrillation to a rhythm associated with a sustainable cardiac output. There is currently no effective method of recording the degree of antegrade coronary artery flow during chest compres... |
4,971 | Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators. | Sleep-disordered breathing (SDB) has been associated with various benign cardiac arrhythmias occurring during sleep.</AbstractText>The purpose of this study was to demonstrate that SDB contributes to the development of life-threatening ventricular arrhythmias in patients with an established arrhythmic substrate.</Abstr... |
4,972 | The impact of cardiac resynchronization therapy on the incidence of ventricular arrhythmias in mild heart failure. | Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular (LV) remodeling in selected populations. However, the effect of CRT on ventricular arrhythmias is controversial. This is particularly important among patients with mild heart failure (HF), in wh... |
4,973 | Effects of mineralocorticoid receptor antagonist spironolactone on atrial conduction and remodeling in patients with heart failure. | Spironolactone was shown to reduce mortality in patients with heart failure (HF). However, the effect of spironolactone on the incidence of atrial fibrillation remains unknown. Therefore, we examined the effects of spironolactone on atrial conduction and remodeling in patients with HF.</AbstractText>A total of 21 patie... |
4,974 | Nurse-initiated defibrillation: are nurses confident enough? | To determine the capability of nurses to identify ventricular fibrillation (VF) and ventricular tachycardia (VT) rhythms on an ECG and carry out subsequent defibrillation on their own as soon as they identify and confirm cardiac arrest.</AbstractText>This was a prospective cohort study to determine the capability of em... |
4,975 | Therapeutic hypothermia for out-of-hospital cardiac arrest: implementation in a district general hospital emergency department. | The use of therapeutic hypothermia is recommended for unconscious adult patients with return of spontaneous circulation (ROSC) after out-of-hospital ventricular fibrillation cardiac arrest. There is evidence that the time taken to achieve target temperature impacts survival.</AbstractText>To audit the performance of an... |
4,976 | Effect of previous statin use on the incidence of sustained ventricular tachycardia and ventricular fibrillation in patients presenting with acute coronary syndrome. | Recent studies suggest that statins have anti-arrhythmic effects. The aim of this study was to evaluate the effects of statins on sustained ventricular tachycardia or ventricular fibrillation (S-VT or VF) in patients presenting with acute coronary syndrome (ACS).</AbstractText>The population of this study consisted of ... |
4,977 | Out-of-hospital cardiac arrest-review of demographics in South Australia to inform decisions about the provision of automatic external defibrillators within the community. | Sudden, out-of-hospital cardiac arrest (OHCA) has an annual incidence of approximately 50 per 100,000 population. Public access defibrillation is seen as one of the key strategies in the chain-of-survival for OHCA. Positioning of these devices is important for the maximization of public health outcomes. The literature ... |
4,978 | Cardiac arrest in the out-of-hospital setting: when to halt resuscitation. | In out-of-hospital settings, when is it reasonable to halt attempts to resuscitate a victim of sudden cardiac arrest? To answer these questions, we reviewed the relevant literature using the standard Prescrire methodology. Retrospective studies of several thousand cases suggest that the chances of survival depend on ho... |
4,979 | Thrombosuction with export aspiration catheter during PCI in acute MI. | The angiographic demonstration of thrombus laden LAD in a ventilated young man with IABP (to combat cardiogenic shock) demanded thrombosuction. Following thrombosuction no significant lesion was visible that could have mandated PTCA-Stenting. Follow-up coronary angiography in this hyperhomocysteinaemic young subject af... |
4,980 | Beta blockers in arrhythmias: when and where to use? | Beta blockers are often the first line of medications used in treatment of arrhythmias. Their role has been established in treatment of Supraventricular tachycardia (SVT) and Ventricular tachyarrhythmias (VT). Beta Blockers are also used as prophylactic medications in SVT, VT and Sudden Cardiac Arrest survivors. They a... |
4,981 | [Pre-excitation pattern associated with accessory pathway related tachycardia: case report]. | Pre-excitation is based on an accessory conduction pathway between the atrium and ventricle. The term Wolff-Parkinson-White (WPW) syndrome is used for patients with the pre-excitation/WPW pattern associated with AP-related tachycardia.</AbstractText>We present a 52-year-old man with severe palpitation, fatigue, lighthe... |
4,982 | Cardioprotective effects of luteolin during ischemia-reperfusion injury in rats. | Antioxidants effectively reduce ischemia-reperfusion (IR) injury. The cardioprotective effects of luteolin, a flavonoid that exhibits antioxidant properties and is widely available in many fruits and vegetables, were examined in rats subjected to myocardial IR injury.</AbstractText>Rats were subjected to myocardial isc... |
4,983 | Biological variation of brain natriuretic peptide and cardiac events in stable outpatients with nonischemic chronic heart failure. | To evaluate the biological variation and prognostic value of brain natriuretic peptide (BNP) for stable outpatients with nonischemic chronic heart failure (NICHF).</AbstractText>Biological variation in BNP was evaluated using an automated assay system in 140 outpatients with NICHF. The stable clinical condition during ... |
4,984 | Effect of therapeutic hypothermia vs δ-opioid receptor agonist on post resuscitation myocardial function in a rat model of CPR. | This study is to compare the effect of the δ-opioid receptor agonist, D-Ala(2)-D-Leu(5) enkephalin (DADLE) with normothermic control and therapeutic hypothermia on post resuscitation myocardial function and 72-h survival in a rat model of cardiac arrest and resuscitation.</AbstractText>Ventricular fibrillation (V... |
4,985 | [Chinese risk stratification scoring system for coronary artery bypass grafting]. | To construct a scoring system for the prediction of in-hospital mortality in Chinese patients undergoing coronary artery bypass grafting (CABG).</AbstractText>From 2007 to 2008, complete clinical information of 9564 consecutive CABG patients was collected from Chinese coronary artery bypass grafting registry which recr... |
4,986 | [An infant with unexplained epilepsy]. | A 6-month-old male infant with an unremarkable past medical history was admitted to the emergency department in an epileptic state. The seizures were resistant to treatment with conventional drugs. The child was sedated, intubated and admitted to the intensive care department. Despite extensive investigations no underl... |
4,987 | Impaired transport function of the left atrium in patients with lone paroxysmal atrial fibrillation. | Although lone paroxysmal atrial fibrillation (LPAF) is clinically defined as an arrhythmia that occurs in the absence of structural heart disease, it has been suggested that the presence of anatomical substrate is related to LPAF. The aim of the present study is to determine whether structural and functional remodeling... |
4,988 | Vernakalant hydrochloride: A novel atrial-selective agent for the cardioversion of recent-onset atrial fibrillation in the emergency department. | Vernakalant is a relatively atrial-selective antiarrhythmic agent that has been shown to successfully convert atrial fibrillation (AF) to normal sinus rhythm for some patients whose onset of dysrhythmia occurred less than 7 days previously. This study sought to evaluate the efficacy and safety of vernakalant for patien... |
4,989 | Effect of defibrillation energy dose during in-hospital pediatric cardiac arrest. | To examine the effectiveness of initial defibrillation attempts. We hypothesized that (1) an initial shock dose of 2 ± 10 J/kg would be less effective for terminating fibrillation than suggested in published historical data and (2) a 4 J/kg shock dose would be more effective.</AbstractText>This was a National Regi... |
4,990 | Postpartum spontaneous coronary dissection presenting with ventricular fibrillation. | Spontaneous coronary artery dissection is a rare cause of acute coronary syndromes; and one quarter of these patients present during the post-partum period. Furthermore, ventricular fibrillation is a rare presentation of this disease entity.</AbstractText>A 32-year-old woman presented 3 days post Cesarean-section deliv... |
4,991 | The impact of surgical ablation in patients with low ejection fraction, heart failure, and atrial fibrillation. | Surgical ablation procedures that use the Cox-Maze procedure lesion set were shown to be very effective. However, many surgeons are reluctant to perform the procedure, especially in high-risk patients such as those with reduced left ventricular (LV) function. This study explored the potential impact of the Cox-Maze III... |
4,992 | Cardiovascular safety of QVA149, a combination of Indacaterol and NVA237, in COPD patients. | This study assessed the cardiovascular safety of QVA149, an inhaled, once daily, bronchodilator combination containing two 24-hour bronchodilators, the long-acting β(2)-agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium (NVA237). In this randomised, double-blind, placebo-controlled, para... |
4,993 | [Electrophysiological effect of atorvastatin on isolated rat hearts injured by ischemia/reperfusion]. | To investigate the myocardial electrophysiological effect and its underlying mechanisms of atorvastatin (Ator) on isolated rat hearts injured by ischemia/reperfusion (I/R).</AbstractText>Isolated SD rat hearts were mounted on Langendorff system, and a local I/R was induced by ligation (30 min) and release (15 min) of t... |
4,994 | Chronobiology of cardiac ventricular fibrillation development in experimental acute coronary failure. | Numerous experiments on simulation of acute coronary failure in initially intact rabbits showed that under the same experimental conditions irreversible ventricular fibrillation developed in some animals and did not develop in other. We hypothesize that the probability of fibrillation development was determined by the ... |
4,995 | Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia. | Hypothermia is proarrhythmic, and, as the use of therapeutic hypothermia (TH) increases, it is critically important to understand the electrophysiological effects of hypothermia on cardiac myocytes and arrhythmia substrates. We tested the hypothesis that hypothermia-enhanced transmural dispersion of repolarization (DOR... |
4,996 | Early diagnosis of left ventricular diastolic dysfunction in diabetic patients: a possible role for natriuretic peptides. | The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients.</AbstractText>One-hundred and twenty-seven consecutive outpatients with type-2 diabetes mellitus were enrolled into the study. Subjects with overt heart failure or NYHA class > 1... |
4,997 | Present concepts in management of atrial fibrillation: From drug therapy to ablation. | Atrial fibrillation (AF) management requires knowledge of its pattern of presentation, underlying conditions, and decisions about restoration and maintenance of sinus rhythm, control of the ventricular rate, and anti-thrombotic therapy. Maintenance of sinus rhythm is a desirable goal in AF patients because the preventi... |
4,998 | Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications. | The ultrarapid delayed rectifier channels have attracted considerable interest as targets for 'atrial-selective' antiarrhythmic drugs because they contribute to atrial but not to ventricular repolarization. Thus, I(Kur) channel blockers are expected to prolong selectively the atrial effective refractory period without ... |
4,999 | The development of familial hypertrophic cardiomyopathy: from mutation to bedside. | Hypertrophic cardiomyopathy (HCM) is a familial disorder characterized by left ventricular hypertrophy in the absence of other cardiac or systemic disease likely to cause this hypertrophy. HCM is considered a disease of the sarcomere as most causal mutations are identified in genes encoding sarcomeric proteins, althoug... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.