PMID
int64 35.7M
36.4M
| Title/Abstract
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36,293,506
|
transcriptom physiolog analys reveal potenti gene involv photoperiod regul caroten accumul mechan endocarp cucumb cucumi sativus l fruit accumul carotenoid plant key nutrit qualiti mani horticultur crop although structur gene encod biosynthet enzym well character littl known regard photoperiod mediat carotenoid accumul fruit horticultur crop herein perform physiolog transcriptom analys use two cucumb genotyp swcc xis orang flesh photoperiod sensit cc white flesh photoperiod non sensit establish two photoperiod condit ld vs ld four fruit development stage day neutral treatment signific increas fruit caroten content compar short day sd treatment swcc dap signific chang cc day neutral condit elev sugar level fruit compar short day treatment accord go kegg analys predomin express gene relat photosynthesi carotenoid biosynthesi plant hormon signal circadian rhythm carbohydr consist caroten accumul swcc day neutral condit elev express key carotenoid biosynthesi gene psi pds zds lycb chyb later stage day fruit develop compar swcc cc show express deg relat carotenoid cleavag oxid stress signifi reduc caroten level cc cucumb wgcna analysi reveal co express carbohydr relat gene pentos phosphatas synthas glucosidas trehalos phosphatas photoperiod signal gene lhi aprr fkf pif cop gigantea ck carotenoid biosynthet gene thus suggest cross talk mechan carbohydr light relat gene induc caroten accumul result highlight herein provid framework futur gene function analys molecular breed toward enhanc carotenoid accumul edibl plant organ
|
D018553;D044602
|
T116;T168;T126;T169;T002
|
36,293,505
|
use comput drug gene analysi identifi novel therapeut candid retin neuroprotect retin cell death respons irrevers vision loss mani retin disord commerci approv treatment current avail attenu retin cell loss preserv vision seek identifi chemicalsdrug thorough studi biolog function possess neuroprotect effect retina use comput bioinformat approach queri nation center biotechnolog inform ncbi identifi gene associ retin neuroprotect enrich analysi perform use toppgen identifi compound relat identifi gene analysi construct pharmacom multipl drug gene interact databas predict compound statist signific associ gene involv retin neuroprotect compound known deleteri effect eg asbesto ethanol clinic indic eg paraquat ozon manual filter identifi numer drugchem class associ multipl gene implic retin neuroprotect use systemat comput approach anti diabet lipid lower medicin antioxid among treatment anticip analysi mani drug could readili repurpos retin neuroprotect techniqu serv unbias tool util futur lead focus preclin clinic investig complex process neuroprotect well wide rang ocular patholog
|
D018696;D010126
|
T121;T103;T169
|
36,293,504
|
oncoly virotherapi prostat cancer light fire winter common cancer genitourinari system prostat cancer pca global men health problem whose treatment urgent research issu treatment option pca includ activ surveil surgeri endocrin therapi chemotherapi radiat therapi immunotherapi etc howev cancer progress effect treatment option gradual decreas especi metastat castrat resist prostat cancer mcrpc fewer therapeut option shorter surviv period wors prognosi reason oncolyt viral therapi pv except properti select tumor kill relat good safeti human potenti transgen deliveri attract increas attent new form anti tumor strategi pca grow evid ov kill tumor cell direct lysi also activ anticanc immun act tumor microenviron tme therebi prevent tumor growth fact evid efficaci strategi observ sinc late th centuri howev subsequ interest wane renew interest therapi due advanc biotechnolog method innov end th centuri also begin pca therapi ov moreov combin chemotherapi radiotherapi gene therapi immunotherapi ov virus wide rang applic provid effect therapeut result treatment pca
|
D050130;D011471;D050504
|
T061;T005;T191
|
36,293,503
|
small extracellular vesicl hypox tripl negat breast cancer cell induc oxygen depend cell invas hypoxia condit low oxygen frequent found tripl negat breast tumor tnbc promot extracellular vesicl ev secret favor cell invas complex process cell morpholog alter dynam focal adhes spot creat ecm remodel investig invas properti trigger tnbc deriv hypox small ev sevh vitro cell cultur hypox normox condit use phenotyp proteom approach sevh character demonstr increas protein abund divers normox sev sevn enrich pro invas pathway normox cell sevh promot invas behavior pro migratori morpholog invadopodia develop ecm degrad matrix metalloproteas mmp secret proteom profil cultur cell expos sevh determin enrich metabol process cell cycl modul cell health escap apoptot pathway hypoxia sevh respons proteolyt catabol pathway induc interf integrin avail gelatinas express overal result demonstr import hypox signal via sev tumor earli establish metastasi
|
D064726;D000067128
|
T026;T191
|
36,293,502
|
serratiopeptidas affect physiolog pseudomona aeruginosa isol cystic fibrosi patient pseudomona aeruginosa frequent involv cystic fibrosi cf airway infect biofilm motil product toxin invas host cell differ factor increas p aeruginosa virul sessil phenotyp offer protect bacteri cell resist antimicrobi host immun attack motil also contribut bacteri colon surfac consequ biofilm format furthermor abil adher prelud intern lung cell common immun evas mechan use intracellular bacteria p aeruginosa previous studi evalu activ metalloproteas serratiopeptidas spep impair virul relat properti gram posit bacteria work aim investig spep effect differ physiolog aspect relat virul p aeruginosa isol cf patient biofilm product pyoverdin pyocyanin product invas alveolar epitheli cell obtain result show spep abl impair attach inert surfac well adhesioninvas eukaryot cell convers spep effect pyocyanin pyoverdin product strong strain depend increas andor decreas product moreov spep seem increas swarm motil staphylolyt proteas product result suggest larg number clinic strain studi depth draw definit conclus differ strain sometim react oppos way specif treatment great interest object futur studi therefor spep affect p aeruginosa physiolog differ act sever bacteri factor relat virul
|
D003550;D011552
|
T047
|
36,293,501
|
overview polyethylen terephthal pet hydrolas effort tailor enzym improv plastic degrad plastic microplast pollut global threat affect ecosystem current generat reach much metric ton peryear soil ecosystem compris agricultur land act microplast sink though impact could unexpect far reach troubl plastic form polyethylen terephthal pet form polymer terephthal acid tpa ethylen glycol eg monom non biodegrad environment pollut current approach use mechan thermal chemic base treatment reduc pet wast remain cost prohibit could potenti produc toxic secondari pollut thus better remedi method must develop deal plastic pollut marin terrestri environ enzymat treatment could plausibl avenu overcom plastic pollut given near ambient condit enzym function without need chemic discoveri sever pet hydrolas along modif enzym consider aid effort improv abil degrad ester bond pet henc review emphas pet degrad microbi hydrolas contribut allevi environment microplast inform molecular degrad mechan pet also highlight review might use futur ration engin pet hydrolyz enzym
|
D011093;D004785
|
T131;T122;T109
|
36,293,500
|
pharmacolog therapeut applic esculetin esculetin coumarin compound belong class benzopyron enrich various plant sonchus grandifolius aesculus turbinata etc free radic lead develop oxid stress caus inflamm arthriti cancer diabet fatti liver diseas etc reduc efficaci anticanc drug activ inflammatori signal pathway degrad joint cartilag disrupt glycem index normal function liver enzym instanc current treatment modal use arthriti non steroid anti inflammatori drug diseas modifi anti rheumatoid drug lipoxygenas inhibitor present limit efficaci advers effect thus constant need find newer safer altern esculetin immens antioxid potenti therebi allevi arthriti diabet malign hepat disord structur esculetin contain two hydroxyl group enhanc abil function antioxid inhibit oxid stress patholog condit leukotrien b synthesi nf b mpak pathway activ inflammatori cytokin product main caus bone joint deterior arthriti wherea esculetin treatment revers factor reliev diseas condit contrast lipid peroxid caus upregul tgf mediat express dysfunct antioxid enzym inhibit esculetin therapi thus reduc liver fibrosi act pikfoxo pathway therefor target nf b pro inflammatori cytokin tgf oxid stress may therapeut strategi allevi arthriti liver fibrosi
|
D000970;D001168
|
T121;T047;T109
|
36,293,499
|
ccbe essenti epicardi function myocardium develop epicardium singl cell layer mesotheli cell play critic role heart develop contribut differ cardiac cell type develop heart epitheli mesenchym transit emt moreov epicardium sourc secret growth factor promot myocardi growth ccbe secret extracellular matrix protein express epicardi cell requir format primit coronari plexus howev role ccbe epicardi develop still unknown use ccbe knockout ko mous model observ loss ccbe lead congenit heart defect includ thinner hyper trabecul ventricular myocardium addit ccbe mutant heart display reduc prolifer cardiomyocyt epicardi cell epicardi outgrowth cultur assay assess epicardi deriv cell epdc migrat show reduc invas collagen gel epdc ccbe ko epicardi explant ccbe ko heart also display fewer nonmyocytenonendotheli cell intramyocardi reduc prolifer rate addit rna seq data experiment valid qrt pcr show mark deregul emt relat gene develop ccbe mutant heart togeth find indic myocardium defect ccbe ko mice aris disrupt epicardi develop function
|
D006321;D038081
|
T023;T038
|
36,293,498
|
associ chang pattern antinuclear autoantibodi immun checkpoint inhibit therapi develop sever immun relat advers event immun relat advers event ira unpredict autoimmun like toxic induc immun checkpoint inhibitor ici ira consequ breakdown self toler ici induc autoantibodi format presenc antinuclear autoantibodi ana report patient develop ira goal compar ana pattern indirect immunofluoresc differ timepoint baselin initi ici treatment analyz role ana pattern chang predictor ira year follow prospect studi consecut patient solid tumor treat anti pd l blockad agent includ septemb march hospit de la santa creu sant pau barcelona spain group patient three group ana de novo patient show new ana pattern time ici initi ana ana posit baselin without chang ana pattern initi treatment non ana ana negat baselin ici initi find associ appear ana ira rate number type ira howev patient ana de novo group show higher sever ira rate grade group addit patient sever ira chang ana pattern preced ira onset conclus found ana induct ici therapi patient result suggest appear ana may predict sever ira
|
D000074322;D009369
|
T129;T121;T191;T116
|
36,293,497
|
unpredict aberr splice product identifi postmortem sudden cardiac death sampl molecular screen pathogen mutat sudden cardiac death scd relat gene common practic scd case howev test result may lead uncertainti identif variant unknown signific vus occur total identifi variant due lack experiment studi genet variant affect potenti splice site variant among difficult interpret aim studi examin rare intron variant identifi exon flank sequenc meet two main object first valid canon intron variant produc aberr splice second determin whether rare intron variant predict vus may affect splice product achiev object heart sampl case scd carri rare intron variant studi sampl analyz use scd gene custom panel sequenc result show rare intron variant affect canon splice site display case would affect splice product possibl caus aberr isoform howev case show normal splice contradict silico result contrari silico result predict effect case experiment result show gt unpredict aberr splice thus deep intron variant like predict effect base result might underestim effect therefor pathogen classif famili member follow
|
D012326;D016757
|
T045;T046
|
36,293,496
|
abnorm express synapt extrasynapt gaba receptor subunit dystrophin defici mdx mous duchenn muscular dystrophi dmd neurodevelopment disord primarili caus loss full length dp dystrophin muscl brain basi central comorbid dmd unclear brain dystrophin play role cluster central gamma aminobutyr acid receptor gaba rs loss mdx mous alter cluster synapt subunit central inhibitori synaps howev divers gabaerg alter model still fragmentari studi analysi vivo pet imag benzodiazepin bind site radioligand reveal global densiti central gaba rs unaffect mdx compar wt mice contrast semi quantit immunoblot immunofluoresc confoc imag tissu section reveal complex differenti pattern alter express level andor cluster distribut varieti synapt extrasynapt gaba r subunit hippocampus cerebellum cortex spinal cord henc dystrophin loss affect stabil synapt gaba rs also influenc subunit composit gaba rs subtyp synapt extrasynapt site studi provid new molecular outcom measur new rout evalu impact treatment aim compens alter nervous system dmd
|
D016189;D020388
|
T123;T047;T116
|
36,293,495
|
select revers dipolar cycloaddit oxoindolin yliden acet nitron synthesi function spiroisoxazolidin dipolar cycloaddit oxoindolin yliden acet function aldo ketonitron proceed good select provid new high function spiroisoxazolidin characterist featur reaction revers allow control diastereoselect cycloaddit reduct obtain adduct use zinc powder acet acid lead aminoalcohol spirolacton number spiro compound obtain anticanc activ found
|
D013141
|
T109
|
36,293,494
|
cabozantinib load plga nanoparticl potenti adjuv strategi surgic resect high risk non metastat renal cell carcinoma patient high risk non metastat renal cell carcinoma rcc risk metastat relaps follow nephrectomi cabozantinib cz potent multitarget tyrosin kinas inhibitor interfer angiogenesi immunosuppress associ surgeri induc metastasi explor therapeut potenti cz load poli lactic co glycol acid plga nanoparticl cz plga nps adjuv strategi target post nephrectomi metastasi clinic relev sublin recapitul post nephrectomi lung metastasi high risk human rcc name renca srlu luc establish vivo serial select luciferas express murin rcc renca luc cell cz encapsul plga nps via convent singl emuls techniqu multifacet preclin antimetastat efficaci cz plga nps assess renca srlu luc cell cz plga nps smooth surfac display desir physicochem properti good cz encapsul effici well control sustain cz releas cz plga nps exhibit remark dose depend toxic renca srlu luc cell induc gm cell cycl arrest apoptosi cz plga nps attenu vitro coloni format migrat invas abrog akt erk activ intraven inject cz plga nps mark reduc lung metastat burden prolong lifespan favor safeti renca srlu luc experiment lung metastasi model novel cz plga nps system multifacet antimetastat effect allevi target toxic potenti promis adjunct agent patient surgic resect high risk rcc
|
D002292;D053758;D007680;D008175
|
T191;T073
|
36,293,493
|
identifi hub gene associ neoadjuv chemotherapi resist breast cancer potenti drug repurpos develop precis medicin breast cancer second lead caus morbid mortal women worldwid despit advanc clinic applic neoadjuv chemotherapi nac drug resist remain major concern hinder treatment efficaci thus identifi key gene involv drive nac resist target known potenti fda approv drug could appli advanc precis medicin strategi aim perform integr bioinformat studi identifi key gene associ nac resist breast cancer perform drug repurpos identifi potenti drug could use combin nac overcom drug resist studi use public avail rna seq dataset sampl breast cancer patient sensit resist chemotherapi identifi total differenti express gene nac resist breast cancer patient next perform gene co express network analysi identifi signific co express gene modul follow mcc multipl correl cluster cluster algorithm identifi key hub gene associ nac resist mrna mirna network analysi highlight potenti impact hub gene alter regulatori network nac resist breast cancer cell sever hub gene found signific involv poor overal surviv breast cancer patient final identifi fda approv drug could use potenti drug repurpos hub gene altogeth find provid new insight molecular mechan nac resist pave way drug repurpos techniqu person treatment overcom nac resist breast cancer
|
D001943;D035683
|
T123;T191;T114
|
36,293,492
|
matrix metalloproteinas gene polymorph associ breast cancer caucasian women russia conduct studi explor associ matrix metalloproteinas mmp gene polymorph breast cancer bc risk caucasian women russia total affect bc unaffect cancer free women includ case control retrospect studi bc relat gene previous studi ten singl nucleotid polymorph snps five mmp gene mmp genotyp bc risk calcul logist regress evalu snps independ effect model base multifactor dimension reduct mb mdr identifi snp snp interact method allel variant distribut c gt g rs c c gt g rs mmp signific differ bc cancer free women g minor allel snps manifest disord protect effect respect p perm eleven haplotyp six snps mmp involv bc risk nine haplotyp protect two haplotyp effect snps mmp gene examin associ bc within snp snp interact simul model pivot role two locus rs rs mmp epistat interact defin bc entropi within genet model silico bioinformat bc suscept mmp polymorph loci locat function activ genom region impact gene express splice regul mammari gland biolog pathway bc mmp candid gene main realiz due metalloendopeptidas activ extracellular matrix organ structur disassembl metabol process etc conclus data show mmp gene polymorph relat bc suscept caucasian women russia
|
D020780;D001943
|
T191;T126;T116
|
36,293,491
|
experiment evalu quantum dot antibodi conjug surfac plasmon reson spectroscopi applic antibodi function quantum dot qds differ area wide describ literatur howev standard routin method obtain inform conjug effici qds antibodi term interact function qds specif antigen still lack herein surfac plasmon reson spr spectroscopi propos purpos gold coat spr sensor disk modifi self assembl monolay mercaptoundecano acid carbodiimid cross linker chemistri use coval immobil cd biomark premodifi surfac aucd meanwhil qds function amin derivat polyethylen glycol peg qds nh chosen conjug antibodi low non specif adsorpt aucd surfac prior conjug surfac bind capac bmax equilibrium dissoci constant kd specif antibodi cd anti cd found respect qds nh anti cd conjug initi molar ratio spr measur show conjug qds anti cd prepar use molar ratio interact compar immobil cd biomark equilibrium angl case fold concentr anti cd calcul respect could explain qds nh anti cd similar surfac load four molecul per qds nh similar hydrodynam diamet nm ratio respect initi qds nh anti cd molar ratio chosen optim spr spectroscopi prove right choic qds anti cd conjug optim use evalu conjug effici nanostructur various bio recognit molecul
|
D045663
|
T073
|
36,293,490
|
promis therapi atrial fibril ventricular tachycardia sudden cardiac death due arrhythmia atrial fibril ventricular tachycardia account death myocardi infarct increas burden atrial fibril ventricular tachycardia structur electr remodel heart current manag new onset atrial fibril includ electr cardiovers high convers rate pharmacolog cardiovers less convers rate atrial fibril convert focus becom control symptom ensur constant rhythm rate control without consid contributori factor autonom imbal recent huge success obtain develop ablat techniqu address vagal nerv stimul hand ventricular tachycardia sensit drug therapi howev case non respons drug usual therapeut choic repres stereotact ablat therapi cathet ablat review focus newli develop strategi treatment arrhythmia clinic practic specif vernakal low level tragus stimul atrial fibril stereotact ablat therapi drug refractori ventricular tachycardia therapi import signific improv manag atrial fibril ventricular tachycardia provid safer profil current therapi higher success rate current solut low cost deliveri
|
D001281;D017180;D017115
|
T061;T047;T046
|
36,293,489
|
conform heterogen frustrat tumor suppressor p tune punctual mutat conform heterogen p tumor suppressor wild type pwt mutat form investig comput approach includ model atom molecular dynam md simul four differ punctual mutat prh prq prh prw known affect dna bind belong frequent hot spot mutat human cancer taken consider md trajectori wild type mutat p form analyz essenti dynam extract relev collect motion frustrat method evalu degeneraci energi landscap found p character wide collect motion energi landscap exhibit rather high frustrat level especi region involv bind physiolog ligand punctual mutat give rise modul collect motion frustrat p differ effect depend mutat region pwt mutat form character high frustrat level also larg involv collect motion correl discuss also connect intrins disord charact p central function role
|
D016159;D005639
|
T123;T116;T041
|
36,293,488
|
senp promot vsmc phenotyp switch via myocardin de sumoyl myocardin master regul smooth muscl cell smc differenti induc express smooth muscl specif gene direct associ serum respons factor srf past two decad signific insight obtain regard regulatori control myocardin express transcript activ transcript post transcript post translat level howev whether sumoyl play import role modul myocardin function remain elus studi found myocardin modifi sumo lysin revers de conjug senp sumo modif promot myocardin protein stabil wherea senp facilit proteasom depend degrad moreov found pia sumo e ligas enhanc sumoyl protein stabil myocardin import found senp promot phenotyp switch vsmc therefor conclud senp promot vsmc phenotyp switch via de sumoyl myocardin regul protein stabil
|
D058207;D026362
|
T123;T116;T044
|
36,293,487
|
monodelphi domestica induc pluripot stem cell reveal metatherian pluripot architectur marsupi power compar model understand mammalian biolog howev uniqu characterist embryolog marsupi pluripot architectur remain fulli understood nobodi succeed develop embryon stem cell esc marsupi speci develop integr free ipsc reprogram method establish valid ipsc two inbr strain marsupi monodelphi domestica monoipsc show signific de gene high uniform r ci reset cellular transcriptom similar eutherian esc ipsc overal transcriptom profil howev monoipsc show uniqu regulatori architectur core pluripot transcript factor like marsupi epiblast result suggest pouf splice variant specif express pouf synergist regul opossum pluripot gene network plausibl pouf pouf splice variant xm sox form self regulatori network nanog express howev specif monoipsc epiblast furthermor pouf high express trophectoderm cell wherea pluripot transcript factor signific downregul suggest regulatori architectur core pluripot gene marsupi may distinct eutherian
|
D048309;D057026
|
T015;T025
|
36,293,486
|
cannabinoid cb receptor delet catecholaminerg neuron protect diet induc obes high calori diet chronic stress major contributor develop obes metabol disord two risk factor regul activ sympathet nervous system sns present studi show key role cannabinoid type receptor cb dopamin hydroxylas dbh express cell regul sns activ diet induc obes model cb delet cell protect mice diet induc weight gain increas sympathet drive result reduc adipogenesi white adipos tissu enhanc thermogenesi brown adipos tissu delet cb catecholaminerg neuron increas plasma norepinephrin level norepinephrin turnov sympathet activ viscer fat coincid lower neuropeptid npi level viscer fat mutant mice compar control furthermor mutant mice show decreas plasma corticosteron level studi provid new insight mechan under role endocannabinoid system regul energi balanc cb delet dbh posit cell protect diet induc weight gain via multipl mechan increas sns activ reduc npi activ decreas basal hypothalam pituitari adren hpa axi activ
|
D009478;D002186
|
T123;T121;T116;T109
|
36,293,485
|
lipoteicho acid lipopolysaccharid affect p inflammatori marker modul promot inhibitori effect osteogen differenti lipoteicho acid lta lipopolysaccharid lps cell wall compon gram posit gram negat bacteria respect notabl oral microflora consist varieti bacteri speci osteomyel jaw caus dental infect present symptom bone resorpt osteosclerosi howev effect lta lps osteogen differenti yet clarifi examin effect lta lps osteoblast found lta alon promot alizarin red stain low concentr inhibit high concentr addit gene express osteogen marker alp ocn opg enhanc low concentr lta high concentr lps suppress calcif potenti addit low concentr lta inhibit calcif suppress restor gene express level suppress bone differenti marker alp bsp ocn moreov suppress p signal pathway associ bone differenti oppos effect gene level express tumor necrosi factor tnf interleukin il suggest mix lta lps infect opposit effect bone differenti concentr gradient involv inflammatori marker tnf il p pathway
|
D008070;D014409
|
T129;T116;T109
|
36,293,484
|
toler adapt cell respons elicit micromonospora sp face tellurit toxic biolog physic chemic character intens use tellurium te industri applic along improp dispos te deriv caus accumul environ oxyanion tellurit teo solubl bioavail toxic te speci hand tellurium rare metalloid element whose natur suppli end short possibl econom technolog effect thus te contain wast repres sourc te recycl recov among explor strategi microbi teo biotransform less toxic te speci appropri concern circular economi actinomycet ideal candid environment biotechnolog howev explor teo biotransform scarc due limit knowledg regard oxyanion microbi process gap fill investig cell toler adapt respons teo micromonospora strain isol metal loid rich environ aim integr biolog physic chemic statist approach combin physiolog biochem assay confoc scan electron sem microscopi fourier transform infrar spectroscopi attenu total reflect mode atr ftir design micromonospora cell expos teo differ physiolog state reveal seri strike cell respons cell morpholog chang extracellular polymer substanc product cell membran damag modif oxid stress burst protein aggreg phosphoryl superoxid dismutas induct result highlight micromonospora strain asset biotechnolog purpos
|
D013691;D008847
|
T131;T196;T007
|
36,293,483
|
lack npr increas vascular endotheli adhes induct integrin beta natriuret peptid receptor npr serv modul vascular endotheli homeostasi interact monocyt endotheli cell may initi endothelium dysfunct known earli hallmark atherosclerosi studi perform rna sequenc analysi aorta npr knockout npr mice found differenti express gene signific relat cell adhes result support increas express intercellular adhes molecul icam aortic endothelium npr mice moreov observ knockdown npr increas icam express promot thp monocyt adhes human umbil vein endotheli cell huvec npr overexpress decreas icam express inhibit adhes monocyt huvec treat tnf cell adhes induc analysi show adhes relat gene enrich focal adhes signal pathway integrin beta itgb determin key gene notabl itgb express increas vascular endothelium npr mice npr knockdown huvec defici itgb decreas icam express attenu monocyt adhes npr knockdown endotheli cell addit reduc npr increas itgb express level found atherosclerosi mous model conclus find demonstr npr defici increas vascular endotheli cell adhes stimul itgb express may contribut develop atherosclerosi
|
D018799;D050197
|
T129;T047;T046;T116
|
36,293,482
|
mechan stimul alter chronic ethanol induc chang vta gaba neuron nac da releas measur withdraw therapeut activ mechanoreceptor mstim osteopathi chiropract acupunctur use hundr year myriad posit outcom previous shown modul fire rate neuron ventral tegment area vta dopamin da releas nucleus accumben nac area interest alcohol use disord aud studi examin effect mstim vta gaba neuron fire rate da releas nac behavior withdraw chronic etoh exposur rat model demonstr concurr administr mstim etoh signific reduc adapt vta gaba neuron da releas respons reinstat dose etoh gkg behavior indic etoh withdraw rear open field cross tail stiff gait anxieti substant amelior concurr applic mstim addit mstim signific increas overal frequenc ultrason vocal suggest increas posit affect state
|
D017557;D004298
|
T123;T023;T121;T109
|
36,293,481
|
enhanc flame retard rigid polyurethan foam polyacrylamidemxen hydrogel nanocomposit coat rigid polyurethan foam rpuf wide use mani field high flammabl frequent releas larg amount toxic smoke combust limit applic hydrogel coat kind environment friend materi contain larg amount water benefici flame retard rpuf mxene two dimension inorgan nanomateri possess larg specif surfac area good thermal stabil perform well smoke suppress physic barrier flammabl gas product heat herein address fire hazard rpuf mxene nanosheet first graft doubl bond introduc polyacrylamid hydrogel system radic polymer prepar mxene base hydrogel coat paam mxene flame retard rpuf coat rpuf prepar paint paam mxene coat onto rpuf surfac dispers modifi mxene nanosheet mxene hydrogel improv compar pristin mxene addit mxene contribut thermal stabil enhanc paam mxene cone calorimetri water retent test open flame combust test use studi flame retard smoke suppress water retent flame retard rpuf coat rpuf exhibit signific flame retard includ reduc peak heat releas rate phrr maximum total heat releas rate thr maximum total smoke product maximum result show mxene mxene improv flame retard smoke suppress water retent hydrogel mxene better smoke suppress effect mxene ascrib better dispers mxene pristin mxene detail perform improv mechan propos work improv flame retard rpuf also promot explor new flame retard strategi rpuf
|
D005411;D053761
|
T120;T073
|
36,293,480
|
restrict flavivirus interferon stimul gene shflcorf flavivirus genus flavivirus flavivirida famili includ mani arthropod born virus often caus life threaten diseas human hemorrhag enceph although flavivirus signific clinic impact becom appar flavivirus replic restrict cellular factor induc interferon ifn respons call ifn stimul gene isg shfl shiftless antivir inhibitor ribosom frameshift novel isg inhibit dengu virus denv west nile virus wnv zika virus zikv japanes enceph virus jev infect interest shfl function broad spectrum antivir factor exhibit suppress activ various type rna dna virus review summar current understand molecular mechan shfl inhibit flavivirus infect discuss molecular basi inhibitori mechan use predict tertiari structur shfl generat program alphafold
|
D005416;D000071244;D000071243;D004664;D004672
|
T005;T047
|
36,293,479
|
role dna methyl within cypa gene associ genet environment risk factor stress relat manifest schizophrenia genet environment influenc schizophrenia might converg dna methyl dnam within loci associ diseas implic respons environment stress examin whether dnam within cypa hypothalamus pituitari adren axi gene situat within schizophrenia risk locus q would mediat genet environment effect stress relat schizophrenia symptom dnam within exon intron fragment cypa assess blood schizophrenia patient control use singl molecul real time bisulfit sequenc addit vntr polymorph asmt gene plausibl causal variant within q locus genotyp extend patient control sampl n effect local haplotyp vntr polyenvirom risk score per dnam episod verbal memori execut function depress suicid patient assess haplotyp per differenti influenc dnam four variabl methyl site identifi within fragment stochast addit allel specif effect found allel specif dnam cpg snp rs mediat relationship local haplotyp verbal fluenci find confirm interrog dna fragment place genet environment risk factor converg influenc schizophrenia symptom dnam
|
D019175;D012559
|
T044;T048
|
36,293,478
|
circul small ev mirna predictor patholog respons neo adjuv therapi breast cancer patient neo adjuv therapi nat increas use clinic treatment breast cancer bc patholog respons nat associ improv patient surviv howev current techniqu employ assess tumor respons signific limit small ev sev encapsul mirna emerg promis new biomark diagnosi predict therefor studi aim explor predict valu mirna patholog respons nat bc employ bioinformat tool select set mirna evalu express plasma sev bc biopsi twelv mirna identifi sev mir p p p p signific associ miller payn mp patholog respons nat moreov mir p p p mir p independ predictor mp respons nat howev express mirna show correl sev tissu sampl indic mechan mirna sort sev still need elucid function analysi mirna target gene drug interact reveal candid mirna target regul differ nat regimen evid support role govern patient therapi respons highlight potenti use predict biomark
|
D035683;D001943
|
T123;T191;T114
|
36,293,477
|
epigenet chang prion prion like neurodegen diseas recent advanc potenti biomark futur perspect prion diseas transmiss spongiform encephalopathi tses caus conform convers nativ cellular prion protein prp c abnorm infecti isoform call prp sc amyotroph later sclerosi alzheim parkinson huntington diseas also known prion like diseas share common featur prion diseas includ protein misfold aggreg well spread misfold protein differ brain region increas evid propos involv epigenet mechan name dna methyl post translat modif histon microrna mediat post transcript gene regul pathogenesi prion like diseas littl known role epigenet modif prion diseas recent find also point potenti regulatori role epigenet mechan patholog diseas review highlight recent find epigenet modif tses prion like diseas discuss potenti role mechan diseas patholog use potenti biomark
|
D011328;D019636;D017096;D035683
|
T123;T116;T005;T114;T047
|
36,293,476
|
mitochondria target polym micell stepwis respons releas gemcitabin destroy mitochondria nucleus combin antitumor chemotherapi mitochondri dna nuclear dna essenti genet materi play import role maintain normal metabol surviv prolifer cell construct mitochondria target stimuli respons nano drug deliveri system releas chemotherapeut agent stepwis respons manner destroy mitochondri dna nuclear dna simultan effect way improv anti tumor effect chemotherapeut agent studi new mitochondria target phros dual respons block copolym tpp pegk b bs aa n p untarget phros dual respons copolym mpegk b bs aa n p ph singl respons copolym mpegk b ah aa n p ros singl respons copolym mpegk b sa tg n p non respons copolym mpeg b pcl p construct phros respons properti character proton nuclear magnet reson h nmr dynam light scatter dls anticanc chemotherapeut agent gemcitabin gem fluoresc substanc nile red nr load polym micell result mitochondri coloc experi indic carboxypentyl triphenyl phosphonium bromid tpp function p micell could effici target locat mitochondria result cellular uptak experi show phros dual respons gem load p p micell faster intern entri nucleus rate singl respons non respons gem load micell vitro releas experi suggest phros dual respons gemp gemp micell higher cumul releas singl respons gemp gemp micell vitro cytotox experi show mitochondria target dual respons gemp micell lowest ic valu cytotox effect dual respons gemp micell superior singl respons non respons drug load micell
|
D008823;D000970
|
T121;T109
|
36,293,475
|
potenti urin proteom biomark focal segment glomerulosclerosi minim chang diseas primari focal segment glomerulosclerosi fsgs along minim chang diseas mcd diseas primari podocyt damag clinic manifest nephrot syndrom pathogenesi podocytopathi still unknown therefor search biomark diseas ongo aim determin proteom profil urin patient fsgs mcd patient confirm diagnosi fsgs n mcd n recruit studi comprehens assess sever fsgs special index introduc calcul follow first score assign depend level egfr second score depend proteinuria level third score resist steroid therapi patient sum score less includ group group urinari proteom analyz use liquid chromatographymass spectrometri proteom profil patient sever progress fsgs group mild fsgs group mcd compar result label free analysi valid use target lc ms base multipl reaction monitor mrm stabl isotop label peptid standard sis avail protein identifi differenti least one pair group quantit mrm sis valid measur protein reveal protein signific differ least one two group pair protein valid comparison addit protein valid mrm sis analysi show direct chang discoveri stage label free lc ms analysi ie regul mcd fsgs fsgs patient fsgs group show signific differ profil fsgs group mcd among signific differenti protein signific apolipoprotein iv hemopexin vitronectin gelsolin compon complement system cb factor b retinol vitamin bind protein patient mild form fsgs mcd show lower level cystatin c gelsolin complement factor
|
D009402;D005923
|
T047
|
36,293,474
|
metabolom profil nephrot syndrom toward biomark discoveri nephrot syndrom ns kidney ill character excess proteinuria hypoalbuminemia edema hyperlipidemia may lead kidney failur necessit renal transplant end stage renal diseas cardiovascular issu mortal much common ns therefor present studi aim identifi potenti new biomark associ pathogenesi diagnosi ns liquid chromatographi mass spectrometri lc ms metabolom approach appli profil metabolom human serum patient ns total metabolit signific alter ns compar control arginin prolin tryptophan metabol arginin phenylalanin tyrosin tryptophan biosynthesi common metabol pathway dysregul ns furthermor alanyl lysin isoleucyl threonin highest discrimin ns healthi group candid biomark may lead understand possibl metabol alter associ ns serv potenti diagnost biomark
|
D009404
|
T047
|
36,293,473
|
gper agonist g prevent wnt induc jun upregul ht colorect cancer cell women consist show lower incid mortal rate colorect cancer crc compar men epidemiolog evid support pivot role estrogen protect women crc estrogen protect effect crc main attribut estrogen receptor beta er howev express lost crc progress role g protein coupl membran estrogen receptor gpergpergpr remain express er loss crc current debat hypothesis estrogen protect crc progress via gper modul wnt catenin prolif pathway common hyperactiv crc sought evid sexual dimorph within wnt catenin pathway conduct kaplan meier analys base gene express wnt receptor fzd frizzl multipl public domain crc patient data set high express fzd associ poor relaps free surviv rate male femal popul femal deriv ht crc cell line show catenin nuclear transloc affect treatment gper agonist g howev g prevent wnt pathway induc upregul jun oncogen novel find indic mechanist role gper protect crc progress select reduc tumorigen effect hyperact wnt catenin signal pathway crc
|
D051176;D015179
|
T123;T191;T116
|
36,293,472
|
anthocyanin accumul provid protect high light stress reduc photosynthesi appl leav photoprotect role anthocyanin remain controversi studi explor effect anthocyanin photosynthesi photoprotect use transgen galaxi gala appl plant overexpress mdmyb high light stress overexpress mdmyb dramat enhanc leaf anthocyanin accumul allow visibl light absorb particular green region howev post transcript regul anthocyanin accumul lower leaf photosynthesi photochem reaction co fixat capac anthocyanin accumul also led decreas de epoxid state xanthophyl cycl antioxid capac like respons light shield effect anthocyanin indic higher chlorophyl concentr lower chlorophyl ab ratio laboratori condit detach leav lost carbon fixat capac due limit co suppli photoinhibit detach transgen red leav less sever strong white green blue light becam sever respons strong red light compar wild type field condit photosynthesi perform normal green transgen red leav degre photoinhibit compar transgen red leav wild type leav less sever transgen young shoot bark compar wild type taken togeth data show anthocyanin protect plant high light stress absorb excess visibl light despit reduc photosynthesi
|
D027845;D007887
|
T168;T002
|
36,293,471
|
use retinoid prevent treatment skin cancer updat review retinoid natur synthet vitamin deriv effect prevent treatment non melanoma skin cancer nmsc nmscs constitut heterogen group non melanocyt deriv skin cancer impos substanti burden patient healthcar system includ entiti basal cell carcinoma cutan squamous cell carcinoma collect call keratinocyt carcinoma cutan lymphoma kaposi sarcoma among other retinoid signal pathway play influenti role skin physiolog patholog compound regul divers biolog process within skin includ prolifer differenti angiogenesi immun regul collect retinoid suppress skin carcinogenesi topic system retinoid investig clinic trial nmsc prophylact treatment desir efficaci toler clinic trial prompt health regulatori bodi approv use retinoid nmsc manag accept label use compound drug skin cancer also describ review comprehens outlin biochemistri retinoid activ skin effect cancer cell adopt clinic practic
|
D012878;D002294;D002280
|
T191
|
36,293,470
|
hybrid coordin network remov pollut wastewat adsorpt properti two coordin polym result reaction dival metal ca co salt carboxyethyl phenyl phosphin acid present paper structur textur character adsorpt experi present adsorb materi prepar use hydrotherm procedur compound ca p ch ch cooh c h caceppa layer topolog phenyl group orient interlay space crystal monoclin system compound co p ch ch coo c h h h coceppa structur compos zig zag chain adsorpt perform caceppa coceppa materi test remov cadmium lead aqueous solut optimum ph ion adsorpt found five adsorb materi pseudo first second order kinet model use fit kinet experiment data langmuir freundlich isotherm use model equilibrium experiment data pseudo second order kinet model langmuir isotherm best describ adsorpt cd pb ion onto studi materi judg result error function correl coeffici sum squar error chi squar test averag relat error analysi studi materi present higher affin cd ion compar adsorpt capac develop remov pb ion aqueous solut coceppa show highest adsorpt perform remov process metal ion aqueous solut compar caceppa q mg cd g coceppa q mg cd g caceppa
|
D014874;D004785
|
T131
|
36,293,469
|
adam adam novel player retinoblastoma carcinogenesi disintegrin metalloproteinas adam famili protein act sheddas import factor number patholog includ cancer suggest promis therapeut target studi present focus involv adam adam retinoblastoma rb common malign intraocular childhood tumor signific correl adam express level rb later rb stage observ level adam adam regul mirna mir signific downregul rb cell line reduc mir level simultan upregul adam adam express found rb patient involv adam analyz ectodomain shed neuron cell adhes molecul l lcam shown induc pro tumorigen effect rb confirm lentivir adam adam singl adam doubl knockdown kd induc caspas depend apoptosi reduc cell viabil prolifer growth coloni format capac rb cell moreov differenti phosphoryl serinethreonin kinas akt observ follow adam kd rb cell chicken chorioallanto membran cam assay reveal adam adam deplet decreas tumorigen migrat potenti rb cell vivo thus adam potenti novel target futur therapeut rb approach
|
D012175;D039842;D035683;D019572
|
T123;T191;T116;T114
|
36,293,468
|
tlr pathway associ biomark subarachnoid hemorrhag sah potenti target futur anti inflammatori therapi subarachnoid hemorrhag associ sever neurolog deficit survivor among survivor initi bleed secondari brain injuri lead addit brain damag apart cerebr vasospasm secondari brain injuri main result cerebr inflamm take place brain parenchyma bleed brain innat immun system activ lead disturb brain homeostasi cleavag inflammatori cytokin subsequ neuron cell death toll like receptor tlr signal pathway found play essenti role pathophysiolog acut brain injuri subarachnoid hemorrhag sah tlr express cell surfac microglia key player cellular immun respons brain particip signal pathway tlr pathway like ligand receptor inflammatori cytokin act biomark serv clue regard inflammatori status sah moreov protein complex nlrp inflammasom receptor trem frame tlr pathway indic inflamm review focus activ tlr pathway contributor act biomark neuroinflamm even offer potenti new treatment target secondari neuron cell death sah
|
D013345;D001930
|
T047;T046;T037
|
36,293,467
|
strategi toward produc non polar dolomit nanoparticl nanofil copolym nanocomposit poli ethylen co vinyl acet pevac copolym endow high elast resili properti potenti util various applic howev tensil strength copolym insuffici use certain applic requir enough strength toler high extern tension stress studi dolomit propos nanofil reinforc pevac raw dolomit physic chemic modifi order improv mix abil interfaci adhes pevac dolomit initi size dolomit reduc combin ball mill tip sonic method sem tem xrd use character morphologystructur raw dolomit size reduc dolomit particl size analysi perform confirm averag particl size result show particl size dolomit reduc nm physic modif process size reduct base tem analysi feret diamet f dolomit particl also reduc nm physic modifi dolomit refer dolomit nanoparticl dnps sinc one dimens less nm eg thick width improv dolomit pevac matrix interact chemic modif dnps perform treat dnps stearic acid form non polar dolomit nanoparticl np dnps presenc stearic acid dolomit confirm ftir contact angl analys pevac nanocomposit film np npds nanofil appear homogen exhibit highest increment tensil strength elong break find indic combin ball mill tip sonic effici method produc fine dolomit particl nano size rang wherea chemic surfac modif improv compat dolomit copolym combin physic chemic modif help develop homogen copolym nanocomposit system improv tensil properti
|
D053761;D053758
|
T073
|
36,293,466
|
polysiloxan base polyurethan high strength recycl polysiloxan attract consider attent biomed engin owe inher properti includ good flexibl biocompat howev low mechan strength limit applic scope studi synthes polysiloxan base polyurethan chemic copolymer seri thermoplast polysiloxan polyurethan si tpus synthes use hydroxyl termin polydimethylsiloxan contain two carbam group tail polym chain dicyclohexylmethan diisocyan hmdi butanediol raw materi effect hard segment content soft segment number averag molecular weight properti result tpus investig prepar hmdi base si tpus exhibit good microphas separ excel mechan properti accept repeat process tensil strength sitpu k reach mpa signific higher flexibl polysiloxan materi moreov tensil strength break elong sitpu k maintain respect three cycl regener si tpus prepar work may potenti use gas separ medic materi antifoul coat applic
|
D011140;D012833
|
T122;T109
|
36,293,465
|
role igl preserv solut rat liver scs hope scarciti liver transplant rise new strategi extend donor pool explor one solut use margin graft extend criteria donor present exampl liver steatosi current preserv solut uw htk igl main design static cold storag scs igl modifi version igl develop suitabl scs dynam preserv hypotherm oxygen perfus hope studi investig combin effect igl scs hope compar use preserv solut uw belzer mps four experiment group six rat design use zucker rat group underw h scs igl uw h normotherm machin perfus nmp c mimic transplant hope igl belzer mps perform nmp half rat igl group demonstr lower transaminas signific low level glycocalyx protein casp hmgb perfus data suggest protect role igl fatti liver preserv endotheli glycocalyx apoptosi inflamm
|
D019188;D024243;D005234
|
T123;T122;T116;T047
|
36,293,464
|
stimul mitochondri biogenesi deoxyribonucleosid increas function capac ech defici cell lack effect treatment mitochondri diseas seen develop new approach includ stimul mitochondri biogenesi boost atp product examin effect deoxyribonucleosid dns mitochondri biogenesi function short chain enoyl coa hydratas ech knockout ko cell exhibit combin defect oxid phosphoryl oxpho mitochondri fatti acid oxid fao dns treatment increas mitochondri dna mtdna copi number express mtdna encod transcript control con ech ko cell dns treatment also alter global nuclear gene express key gene set includ respiratori electron transport format atp chemiosmot coupl increas con ech ko cell gene involv oxpho complex biogenesi also upregul con ech ko cell follow dns treatment correspond increas steadi state level holocomplex ech ko cell steadi state level oxpho complex v ciii civ ciciii civ supercomplex also increas dns treatment ech ko cell import treatment dns increas basal maxim mitochondri oxygen consumpt ech ko cell metabol either glucos fatti acid palmitoyl l carnitin find highlight abil dns improv overal mitochondri respiratori function via stimul mitochondri biogenesi face combin defect oxpho fao due ech defici
|
D001678;D004746
|
T070;T126;T116;T043
|
36,293,463
|
extract character platelet inhibitori effect two polysaccharid cs fungus cardiovascular diseas associ platelet hyperact downregul platelet activ one promis antithrombot strategi studi newli extract two polysaccharid purifi exopolysaccharid epsp purifi intercellular exopolysaccharid ipsp cordycep sinensi cs myceli ferment powder investig effect two polysaccharid gut bacteri metabolit platelet function thrombus format epsp ipsp major compos galactos mannos glucos arabinos epsp ipsp main contain gal p glc p glycosid linkag epsp ipsp signific inhibit human platelet activ aggreg dose depend manner attenu thrombus format mice without increas bleed risk furthermor epsp ipsp fecal ferment show enhanc platelet inhibitori effect result demonstr potenti valu cs polysaccharid novel protect ingredi cardiovascular diseas
|
D002318;D032661;D013927
|
T047;T046;T004
|
36,293,462
|
competit sperm mark beetl monitor approach genet biocontrol studi reproduct biolog sperm mark provid key tool reproduct biolog studi also repres valuabl monitor tool genet pest control strategi steril insect techniqu sperm mark line generat introduc transgen mediat express fluoresc protein spermatogenesi homozyg line establish transgenesi approach go genet bottleneck lead reduc fit transgen sit approach most focus dipteran lepidopteran pest far studi provid sperm mark line coleopteran pest model organ red flour beetl tribolium castaneum base tubulin promoterenhanc drive red dsred green egfp fluoresc obtain line reason competit thus use studi reproduct biolog confirm phenomenon last male sperm preced spermatheca deploy long term sperm storag enabl use sperm first mate event even secondari mate event long period time homozygos competit line enabl futur studi analyz control process sperm movement long term storag organ part post mate cryptic femal choic mechan extrem promiscu speci
|
D001517;D014231
|
T204
|
36,293,461
|
role emasr ethanol metabol acinetobact baumannii acinetobact baumannii well known nosocomi pathogen surviv differ environ use intric network regul gene express two compon system tcs form import part regulatori network studi describ identif character novel emasr tcs baumannii construct tn tag mutagenesi librari ema sensor kinas gene emar respons regul gene identifi found ema emar singl mutant doubl mutant unabl replic medium ethanol singl carbon sourc motil biofilm format negat affect doubl mutant transcriptom analysi show mutat emasr dysregul gene requir carbon metabol addit ema emar singl mutant doubl mutant unabl surviv acet acid sodium acet contain medium indic emasr tcs also import acet metabol furthermor virul galleria mellonella diminish ema emar singl doubl mutant taken togeth result show novel emasr tcs involv regul baumannii ethanol metabol acet metabol import implic motil biofilm format virul mutat research under mechan warrant
|
D040981
|
T007
|
36,293,460
|
electrochem activ cnt sheet cathod zn co batteri high demand electrochem storag devic increas need high perform batteri zn co batteri offer promis solut co reduct well energi storag applic studi zn co batteri fabric use carbon nanotub cnt sheet cathod zn plate anod electrochem activ techniqu use increas surfac area cnt electrod rough time copper cu catalyst deposit onto activ cnt electrod use electrodeposit method differ cu load investig optim co reduct final assembl zn co batteri v output voltag current densiti macm higher devic report literatur studi demonstr import activ process enabl catalyst load cathod result addit activ site electroreduct process paper present activ cnt sheet promis cathod materi zn co batteri
|
D037742
|
T104;T073
|
36,293,459
|
flavonoid antidiabet anti inflammatori agent review structur activ relationship base studi meta analysi flavonoid group natur occur polyphenol secondari metabolit report demonstr wide rang pharmacolog properti import antidiabet anti inflammatori effect relationship hyperglycaemia inflamm vascular complic diabet well establish flavonoid possess antidiabet properti may allevi inflamm reduc hyperglycaemia differ mechan action suggest flavonoid biochem properti structur depend howev yet thorough grasp henc main aim review understand antidiabet anti inflammatori properti various structur divers flavonoid identifi key posit respons effect correl effect differ substitut antidiabet anti inflammatori properti general requir flavonoid exert anti inflammatori antidiabet effect found presenc c c doubl bond c ring hydroxyl group c c c c posit ring b flavonoid skeleton furthermor demonstr substitut c posit c ring decreas anti inflammatori action flavonoid enhanc antidiabet activ correl discuss length support flavonoid possess essenti pharmacophor demonstr equipot effect consider structur featur may play import role synthes better flavonoid base drug possess dual antidiabet anti inflammatori effect meta analysi establish role flavonoid antidiabet anti inflammatori agent
|
D005419;D006943
|
T121;T127;T109;T033;T047
|
36,293,458
|
non tradit pro inflammatori pro atherosclerot risk factor relat system lupus erythematosus cardiovascular diseas cvd one lead caus high mortal patient system lupus erythematosus sle framingham risk score tradit risk factor fulli reflect cvd risk sle patient therefor order stratifi high risk patient addit biomark subclin cvd need mechan atherogenesi sle still investig past decad mani report recogn inflamm play crucial role develop atherosclerosi aim report present novel proinflammatori pro atherosclerot risk factor close relat sle inflamm determin increas risk occurr earli cardiovascular event
|
D050197;D008180;D002318
|
T047;T046
|
36,293,457
|
mitochondri dysfunct neurodegen disord role nutrit supplement mitochondri dysfunct implic pathogenesi number neurodegen disord includ parkinson diseas alzheim diseas amyotroph later sclerosi multisystem atrophi progress supranuclear palsi articl concern specif mitochondri dysfunct defin reduc capac atp product role deplet level key nutrit relat metabolit potenti benefit supplement specif nutrient relev normal mitochondri function neurodegen disord articl provid rational combin coq b vitaminsnadh l carnitin vitamin alpha lipoic acid treatment neurodegen disord
|
D008063;D019578
|
T121;T046;T127;T109
|
36,293,456
|
explor absorpt mechan imidazolium base ionic liquid epigallocatechin gallat imidazolium base ionic liquid wild use natur product adsorpt purif work one typic polymer ionic liquid pil synthes use l prolin anion exhibit excel adsorpt capac toward tea polyphenol epigallocatechin gallat egcg adsorpt condit optim respons surfac method rsm optimum condit adsorpt capac pil egcg reach high mgg dynam isotherm research show adsorpt process egcg pil particular meet quasi second order kinet equat monolay adsorpt mechan accord thermodynam paramet analysi adsorpt process endotherm spontan result theoret calcul molecular dock also demonstr interact mechan egcg ionic liquid consid wide applic imidazolium base ionic liquid compon adsorpt purif present studi extend similar experiment mechan valid also repres guid synthesi pil optim adsorpt condit
|
D052578;D001688
|
T120;T123;T121;T103
|
36,293,455
|
identif candid gene regulatori competit endogen rna cerna network under intramuscular fat content yorkshir pig extrem fat deposit phenotyp intramuscular fat imf content vital pork qualiti serv import role econom perform pig industri non code rnas mrnas involv imf deposit howev function regulatori mechan porcin imf remain elus studi assess whole transcriptom express profil longissimus dorsi muscl pig high h low l imf content identifi gene implic porcin imf adipogenesi regulatori function hundr differenti express rnas found involv fatti acid metabol process lipid metabol fat cell differenti furthermor comb co differenti express analys construct compet endogen rnas cerna regulatori network show crosstalk among lncrnas mrnas mirna five circrna mrnas four mirna potenti imf deposit relat cerna subnetwork function lncrnas circrna mstrg ensssct novelcirc novelcirc found act cerna import lipid metabol relat mrnas lep ipk ffar cebpa etc spong function mirna ssc mir ssc mir b ssc mir mir find provid potenti regul molecular regulatori network util research imf trait pig would aid marker assist select improv pork qualiti
|
D062085;D035683
|
T123;T114
|
36,293,454
|
singl cell dna methyl analysi chicken lampbrush chromosom dna methyl essenti epigenet regul mechan implic transcript replic control development reprogram retroel silenc genom process mammalian develop specif dna methyl pattern establish germ cell allow embryon develop less known germ cell dna methyl speci close gap perform singl cell methylom analysi chicken diploten oocyt comprehens character methyl pattern cell obtain methyl base chicken genom segment identifi oocyt specif methyl gene promot data show despit format specif transcript hyperact genom architectur chicken diploten oocyt methyl pattern cell close resembl genom distribut observ somat tissu
|
D019175;D044127
|
T045;T044
|
36,293,453
|
filament hemagglutinin bordetella pertussi interact integrin cdbcd pertussi agent bordetella pertussi produc number virul factor filament hemagglutinin fhab play role b pertussi adhes epitheli phagocyt cell moreov fhab recent found play crucial role nasal caviti infect b pertussi transmiss new host kda fhab protein transloc fhac pore outer bacteri surfac eventu process kda n termin fha fragment sphb proteas fraction matur fha remain associ bacteri cell surfac fha shed bacteri environ previous report indirect evid suggest fha precursor fhab may bind integrin cdbcd human macrophag therefor assess fha bind various cell produc lack integrin show purifi matur fha bind cdbcd result reveal adhes b pertussi cell involv interact bacteri surfac associ fhab andor matur fha integrin cdbcd contrast fha bind strong inhibit micromolar concentr heparin corrobor cell bind fha rule interact heparin bind domain sulfat glycosaminoglycan cell surfac
|
D001886;D014917
|
T047;T007
|
36,293,452
|
comput model imag intracellular oxygen gradient comput model provid mechanist quantit framework describ intracellular spatial heterogen solut oxygen partial pressur po studi develop evalu finit element model oxygen consum mitochondri bioenerget use comsol multiphys program model deriv steadi state oxygen distribut fickian diffus micha menten consumpt kinet mitochondria cytoplasm intrins model paramet diffus maximum consumpt rate estim previous publish valu isol intact mitochondria model compar experiment data collect intracellular mitochondri po level human cervic cancer cell hela differ respiratori state differ level impos po experiment po gradient measur use lifetim imag frster reson energi transfer fret base sensor myoglobin mcherri offer situ real time noninvas measur subcellular po live cell basi result model qualit predict integr experiment data mitochondria divers experiment condit impact chang one mitochondri process overal bioenerget
|
D010100;D010101
|
T201;T123;T196;T121
|
36,293,451
|
anti citrullin peptid antibodi control oral porphyromona aggregatibact speci patient rheumatoid arthriti oral microbiom chang take place initi rheumatoid arthriti ra howev question remain regard oral microbiom pre ra stage individu clinic suspect arthralgia csa two cross section cohort select includ tatarstan women earli ra compar individu csa rang csa n csa n csa n csa n women establish ra median year diagnosi iq amplicon sequenc variant asv obtain oral sampl rrna analyz alpha beta divers along abund genus level decreas oral porphyromona sp observ acpa posit individu predomin earli ra patient compar non ra individu irrespect csa score ra establish cohort porphyromona sp aggregatibact sp reduct associ elev acpa level contrast associ report consid individu genet clinic ra associ factor oral microbiom chang relat genera implic post translat citrullin porphyromona sp aggregatibact sp character ra patient elev acpa level support role acpa control oral microbiom need evalu
|
D000075422;D001172
|
T129;T047;T116
|
36,293,450
|
asprosin paraventricular nucleus induc sympathet activ pressor respons via camp depend ros product asprosin newli discov adipokin involv regul metabol sympathet overact contribut pathogenesi sever cardiovascular diseas paraventricular nucleus pvn hypothalamus play crucial role regul sympathet outflow blood pressur studi design determin role under mechan asprosin pvn regul sympathet outflow blood pressur experi carri male adult sd rat anesthesia renal sympathet nerv activ rsna mean arteri pressur map heart rate hr record pvn microinject perform bilater asprosin mrna protein express high pvn high asprosin express pvn involv parvocellular magnocellular region accord immunohistochem analysi microinject asprosin pvn produc dose relat increas rsna map hr abolish superoxid scaveng tempol antioxid n acetylcystein nac nadph oxidas inhibitor apocynin asprosin promot superoxid product increas nadph oxidas activ pvn furthermor increas camp level adenylyl cyclas ac activ protein kinas pka activ pvn role asprosin increas rsna map hr prevent pretreat ac inhibitor sq pka inhibitor h pvn microinject camp analog db camp pvn play similar role asprosin increas rsna map hr fail augment effect asprosin pretreat pvn microinject sq h abolish role asprosin increas superoxid product nadph oxidas activ pvn result indic asprosin pvn increas sympathet outflow blood pressur heart rate via camp pka signal mediat nadph oxidas activ subsequ superoxid product
|
D010286;D013481
|
T121;T023;T109
|
36,293,449
|
insulin diminish superoxid increas cytosol mitochondria cultur cortic neuron treat toxic glutam glutam excitotox involv pathogenesi mani disord includ stroke traumat brain injuri alzheim diseas central insulin resist comorbid condit neurotox glutam glu primarili associ hyperactiv ionotrop n methyl aspart receptor nmdar caus sustain increas intracellular free calcium concentr ca synchron mitochondri depolar increas intracellular superoxid anion radic product recent found insulin protect neuron excitotox decreas delay calcium deregul dcd howev role insulin product excitotox still need clarifi present studi aim investig insulin effect glutam evok generat dcd use fluoresc indic dihydroethidium mitosox red fura ff cortic neuron found linear correl ca primari cultur rat neuron expos glu insulin signific reduc product intracellular mitochondri primari cultur rat neuron mk inhibitor nmdar gate ca influx complet abrog glutam effect presenc absenc insulin experi sister cultur insulin diminish neuron death consumpt rate ocr
|
D018698;D013481
|
T123;T121;T116;T109
|
36,293,448
|
phenol polyaromat hydrocarbon stronger driver host plant speci shape arbuscular mycorrhiz fungal compon mycorrhizospher chang soil microbi communiti respons hydrocarbon pollut critic indic disturb ecosystem condit core compon communiti function adjust life histori trait host environment factor consist arbuscular mycorrhiz fungi amf amf communiti associ poa triviali phragmit australi grow phenol polynuclear aromat hydrocarbon pah contamin site uncontamin site compar base lsu rdna sequenc dissimilar speci composit communiti structur indic soil pollut main factor negat affect amf divers amf communiti contamin site domin fungal generalist rhizophagus funneliformi claroideoglomus paraglomus wide ecolog toler control site amf communiti character higher taxonom function divers expos contamin host plant ident main driver distinguish two amf metacommun amf communiti uncontamin site repres polonospora paraglomus oehlia nanoglomus rhizoglomus dominikia microdominikia polonosporacea paraglomeracea particular domin ph australi mycorrhizospher high abund earli diverg amf could due use primer abl detect lineag paraglomeraca recogn previous use rdna primer
|
D038821;D055137;D011084;D064307
|
T032;T109;T004;T028;T001
|
36,293,447
|
ectop express hbrpw hevea brasiliensi improv arabidopsi thaliana resist powderi mildew fungi erysiph cichoracearum ucsc rpws resist powderi mildew atyp broad spectrum resist gene provid resist powderi mildew fungi powderi mildew rubber tree one serious fungal diseas affect tree growth latex product howev rpw homolog rubber tree role resist powderi mildew remain unclear studi four rpw gene hbrpw b c identifi rubber tree phylogenet analysi show hbrpw cluster atrpw atrpw arabidopsi hbrpw protein local plasma membran express rubber tree signific induc upon powderi mildew infect transient express hbrpw tobacco leav induc plant immun respons includ accumul reactiv oxygen speci deposit callos plant cell similar induc atrpw consist overexpress hbrpw arabidopsi thaliana enhanc plant resist erysiph cichoracearum ucsc pseudomona syringa pv tomato dc pst dc moreov hbrpw mediat resist powderi mildew salicyl acid sa depend manner taken togeth demonstr new rpw member rubber tree hbrpw could potenti contribut resist powderi mildew
|
D017360;D028482;D029681;D001203
|
T004;T116;T002
|
36,293,446
|
import micromilieu pathophysiolog mineralocorticoid receptor activ mineralocorticoid receptor resid wrong neighborhood mineralocorticoid receptor mr member steroid receptor famili act ligand depend transcript factor addit classic effect water electrolyt balanc involv pathogenesi cardiovascular renal diseas subject research sever year molecular basi latter fulli elucid isol increas concentr mr ligand aldosteron mr express suffic explain long term patholog action receptor sever studi suggest mr activ signal transduct modul surround microenviron therefor play import role mr pathophysiolog effect local chang micromilieu includ hypoxia ischemiareperfus inflamm radic stress aberr salt glucos concentr affect mr activ therefor may influenc probabl unphysiolog mr action surround micromilieu may modul genom mr activ either caus chang mr express mr activ exampl induc posttransl modif mr novel interact coregul dna bind site non classic pathway consid develop treatment option strategi prevent mr associ diseas
|
D018161;D000450
|
T121;T116;T109;T192;T125
|
36,293,445
|
crystal structur cypa complex fluorol identifi substrat access channel high affin ligand bind site cytochrom p cypa major human drug metabol enzym notori known extrem substrat promiscu alloster behavior implic drug drug interact despit extens investig mechan ligand bind cypa fulli understood determin crystal structur cypa complex fluorol small fluoresc dye undergo hydroxyl structur fluorol associ substrat channel well suit bind planar polyaromat molecul bear polar group stabil h bond polar channel residu thr arg establish mutagenesi spectral kinet function data confirm involv strict requir thr associ fluorol collect data identifi substrat channel high affin ligand bind site support notion hydrophob ligand first dock nearbi peripher surfac migrat channel subsequ activ site
|
D051544;D005456
|
T130;T126;T116
|
36,293,444
|
activ mening affer relev trigemin headach pain photothrombot stroke lesion pilot studi mice stroke follow immedi sever headach headach initi activ trigemin mening affer assess chang activ mening affer mice subject cortic photothrombosi cortic photothrombosi induc ipsilater lesion variabl size associ contralater sensorimotor impair nocicept fire mechanosensit piezo channel activ agonist yoda increas mening affer ischem hemispher mening affer also higher maxim spike frequenc baselin activ mechanosensit piezo channel yoda moreov mening affer nocicept fire activ entir induct transient receptor potenti vanilloid trpv channel capsaicin activ observ contralater hemi skull group mice control mice data suggest involv mechanosensit piezo channel capabl maintain high frequenc spike activ nocicept trpv channel trigemin headach pain respons experiment ischem stroke mice
|
D050051;D020521
|
T123;T047;T116
|
36,293,443
|
synthesi anticanc antitubercular properti new chalcon nitrogen contain five member heterocycl hybrid bear sulfonamid moieti new seri sulfonamid b b synthes n sulfon reaction sulfonyl chlorid b five new seri chalcon sulfonamid hybrid f prepar via claisen schmidt condens newli obtain sulfonamid aromat aldehyd f basic medium chalcon substitut chlorin posit seri use precursor generat five member heterocycl pyrazolin b carbothioamid f deriv synthes compound evalu anticanc antituberculosi activ determin anticanc activ compound screen sixti human cancer cell line singl dose compound c high activ lox imvi melanoma ic valu respect chalcon e show remark result entir panel leukemia cell line ic valu moreov compound e f display growth inhibit mycobacterium tuberculosi hrv concentr although show low select cytotox test vero cell line optim could advanc potenti biolog activ select compound
|
D047188;D002599;D000970
|
T121;T109
|
36,293,442
|
rational combin bcl inhibitor venetoclax pik inhibitor bimiralisib treatment idh flt mutat acut myeloid leukemia octob fda grant regular approv venetoclax abt combin hypomethyl agent newli diagnos acut myeloid leukemia aml adult year older patient comorbid preclud intens chemotherapi treatment respons venetoclax combin treatment howev may short live leukemia relaps major caus treatment failur multipl studi confirm upregul anti apoptot protein b cell lymphoma bcl famili activ intracellular signal pathway associ resist venetoclax improv treatment outcom compound target anti apoptot protein signal pathway evalu combin venetoclax studi bcl xl inhibitor mcl inhibitor dual pik mtor inhibitor bimiralisib pqr bmi inhibitor unesbulin ptc mek inhibitor trametinib gsk stat inhibitor c assess singl agent combin venetoclax abil induc apoptosi cell death leukem cell grown absenc presenc bone marrow stroma enhanc cytotox effect present combin treatment venetoclax aml cell line aml patient sampl elev vitro efficaci observ combin treatment venetoclax bimiralisib differ respons marker combin venetoclax bimiralisib combin treatment respond enrich idh flt mutat wherea non respond associ ptpn mutat combin pikmtor dual pathway inhibit bimiralisib bcl inhibit venetoclax emerg candid treatment idh flt mutat aml
|
D015470;D000970
|
T121;T191;T109
|
36,293,441
|
downregul pcbp associ factor protect vascular age via nrf signal pathway activ increas evid shown vascular age key role pathogenesi vascular diseas pcbp associ factor pcaf involv mani vascular patholog process role pcaf vascular age unknown studi aim explor role under mechan pcaf vascular age result demonstr express pcaf associ age age remark increas express pcaf present human atherosclerot coronari arteri downregul pcaf could reduc angiotensin ii angii induc senesc rat aortic endotheli cell ec vitro addit inhibit pcaf garcinol allevi angii induc vascular senesc phenotyp mice downregul pcaf could allevi angii induc oxid stress injuri ec vascular tissu moreov pcaf nuclear factor erythroid relat factor nrf could interact direct downregul pcaf allevi vascular age promot activ nrf enhanc express downstream anti age factor silenc nrf small interf rna attenu protect effect pcaf downregul vascular age find indic downregul pcaf allevi oxid stress activ nrf signal pathway ultim inhibit vascular age thus pcaf may promis target age relat cardiovascular diseas
|
D051267;D000804
|
T123;T121;T116
|
36,293,440
|
contribut jak haplotyp predisposit myeloprolif neoplasm haplotyp ggcc consist set genet variat distribut along chromosom p extend janus kinas gene insulin like mark four joint inherit variant rs rs rs rs haplotyp strong associ develop bcr abl negat myeloprolif neoplasm mpns preced acquisit jakvf variant common genet alter individu hematolog malign also describ one factor increas risk famili mpns five time associ event relat inflammatori dysregul splenomegali splanchnic vein thrombosi budd chiari syndrom increas rbc count platelet leukocyt hematocrit hemoglobin characterist mpns well find still elucid great interest etiopatholog understand hematolog neoplasm consid factor present review aim describ main find discuss involv haplotyp highlight molecular immunolog aspect relev tool clinic practic investig famili case
|
D009196;D009369;D061385
|
T121;T191
|
36,293,439
|
regul molecular target osteosarcoma treatment preval malign bone tumor osteosarcoma affect growth plate long bone adolesc young adult standard chemotherapeut method show poor respons rate patient recurr metastat phase therefor critic develop novel effici target therapi address relaps case regard rna interfer technolog encourag option cancer treatment small interf rnas regul gene express follow rna interfer pathway determin target tissu import select tissu specif promot moreov small interf rnas deliv effect cytoplasm lentivir vector could encapsul deliv desir gene cell integr genom provid long term regul target gene silenc overexpress gene promot tumor cell lose invas prevent prolifer trigger apoptosi uniqu cancer cell among patient requir novel therapeut method treat patient base uniqu mutat sever studi show effect differ approach microrna drug chemotherapi relat method treat diseas howev identifi various target challeng understand diseas progress regard patient specif abnorm gene might target use genom molecular advanc rna interfer approach review potenti therapeut target rna interfer approach applic therapeut option osteosarcoma patient point small interf rna method becom promis approach unmet challeng
|
D012516;D001859;D035683
|
T123;T191;T114
|
36,293,438
|
cellular molecular mechan ozon therapi present knowledg prospect applic complementari adjuv palliat cure ozon therapi increas use global wide varieti diseas
|
D010126
|
T103
|
36,293,437
|
lipid droplet particip zika virus infect lipid droplet lds high conserv dynam intracellular organell function limit serv neutral lipid reservoir also particip non energi storag function cell lipid metabol protect cell stress maintain protein homeostasi regul nuclear function zika virus zikv infect virus hijack lds provid energi lipid sourc viral replic co local zikv capsid c protein lds support role virus replic platform key compart promot generat progeni virus particl howev view multipl function lds role zikv infect need elucid review basic mechan ld biogenesi biolog function discuss zikv infect util effect lds facilit virus replic along futur applic strategi develop new antivir drug base interact zikv lds
|
D000071244;D000071243
|
T005;T047
|
36,293,436
|
ser plsr analysi vagin microflora toward spectral librari microorgan accur identif microorgan belong vagin microflora crucial establish microorgan respons microbi shift benefici symbiot pathogen bacteria understand pathogenesi lead vaginosi vagin infect studi involv surfac enhanc raman spectroscopi ser techniqu compil spectral signatur signific microorgan part natur vagin microbiota vagin pathogen obtain data suppli still develop spectral ser databas microorgan ser result assist partial least squar regress plsr visual disclos depend spectral imag henc biochem composit outer structur work focus common typic reproduct system microorgan lactobacillus spp bifidobacterium spp vagin pathogen bacteria eg gardnerella vaginali prevotella bivia atopobium vagina fungi eg candida albican candida glabrata protozoa trichomona vaginali obtain result prove microorgan uniqu spectral fingerprint differenti rest moreov discrimin obtain high level explain inform subsequ factor eg inter speci distinct candida spp first three factor explain varianc block data within x matrix differenti lactobacillus spp bifidobacterium spp natur flora pathogen eg candida glabrata inform explain level matrix origin data plsr gave us insight discrimin variabl base marker band repres specif compound outer structur microorgan found lactobacillus spp cm fungi cm protozoa cm use signific marker band analysi clinic subject eg vagin swab
|
D064307;D016585
|
T001;T047;T032;T028
|
36,293,435
|
cell compon function tumor microenviron thyroid cancer thyroid cancer common cancer endocrin system thyroid cancer good prognosi resist treatment show aggress behavior like tumor thyroid cancer harbor tumor microenviron tme compos cancer associ fibroblast caf immun cell autoimmun lymphocyt thyroid occur thyroid may associ cancer develop tme involv tumor progress various mechan caf involv tumor progress cell prolifer extracellular matrix ecm remodel immun cell involv tumor progress cell prolifer angiogenesi epitheli mesenchym transform emt immun suppress event activ various cytokin chemokin metabolit secret cell compris tme review focus caf immun cell two import cell compon thyroid cancer tme involv tumor progress explor potenti therapeut target
|
D013964;D000072645
|
T191;T025
|
36,293,434
|
radic peroxid produc f type ferryl form bovin cytochrom c oxidas reduct respiratori cytochrom c oxidas cco associ generat transmembran proton gradient two mechan one proton pump two differ type ferryl intermedi catalyt heme cu b center p f form particip equival ferryl state also form reaction oxid cco h interest acid solut singl molecul h generat addit f type ferryl form f contain contrast catalyt f intermedi free radic heme cu b center work format endogen decay ferryl iron heme radic f intermedi examin combin four experiment approach isotherm titrat calorimetri electron paramagnet reson electron absorpt spectroscopi togeth reduct form defin number electron result consist generat radic f form howev radic catalyt center rapid quench accompani ferryl state heme like intrins oxid enzym
|
D003576;D010545
|
T197;T126;T116
|
36,293,433
|
one step carbon synthesi magnet biochar network structur applic organ pollut control studi magnet biochar uniqu network structur synthes use simpl control method brief microbi filament fungus trichoderma reesei use templat fe ad cultur process result uniform recombin bio assembl properti fungal hypha final magnet biochar bmfhfe synthes control differ heat condit high temperatur process adsorpt fenton like catalyt perform bmfhfe investig use synthet dye malachit green mg antibiot tetracyclin hydrochlorid th organ pollut model result show adsorpt capac bmfhfe mg th mgg respect higher biochar adsorb fenton like catalyt degrad effect organ pollut also better catalyst studi provid magnet biochar excel perform import method use effect improv perform biochar better control organ pollut
|
D004785;D014874
|
T131
|
36,293,432
|
structur interact molecular fibrillar collagen type fibronectin role regul mesenchym stem cell morpholog function activ observ differ structur nativ tissu tissu form vitro caus loss function activ cell cultur vitro lack fundament knowledg protein mechan interact limit abil effect creat vitro nativ tissu collagen abl spontan assembl fibril vitro vivo protein exampl fibronectin notic effect process molecular fibrillar structur collagen play equal import role therefor studi interact molecular fibrillar structur collagen fibronectin atom forc transmiss electron microscopi show presenc fibronectin affect nativ structur diamet collagen fibril confoc microscopi demonstr collagen structur affect cell morpholog cell better spread molecular collagen compar cell cultur fibrillar collagen fibronectin promot format larg number focal contact combin collagen form effect level thus understand mechan relationship protein structur composit effect manag creation vitro new tissu nativ properti
|
D005353;D059630
|
T123;T116;T025
|
36,293,431
|
dysregul hemostasi immunothrombosi cerebr cavern malform cerebr cavern malform ccm neurovascular diseas affect general popul long time ccm research focus genet mutat endotheli junction prolifer recent transcriptom proteom studi reveal hemostat system neuroinflamm play crucial role develop sever cavernoma public come group aim review give overview latest molecular insight interact ccm defici endotheli cell blood compon neurovascular unit specif underscor endotheli dysfunct result dysregul hemostasi bleed hypoxia neurolog symptom conduct thorough review literatur found field increas pois regard ccm hemostat diseas may implic therapi
|
D020786;D006490
|
T121;T019;T191
|
36,293,430
|
relationship inflamm age relat neurocognit chang relationship inflamm age relat neurocognit chang signific may relat age relat immun dysfunct character senesc immun cell elev inflammatori marker peripher circul central nervous system review discuss potenti mechan includ develop vascular inflamm neuroinflamm organell dysfunct abnorm cholesterol metabol glymphat dysfunct well role key molecul play immun cognit interplay propos potenti therapeut pharmacolog behavior strategi amelior age relat neurocognit chang associ inflamm research deciph multidimension role chronic inflamm normal patholog age process help unfold pathophysiolog mechan underpin neurocognit disord insight gain lay path develop cost effect prevent measur buffer delay age relat neurocognit declin
|
D007249;D019965
|
T046;T048
|
36,293,429
|
whole exom sequenc silico analysi human sertoli patient non obstruct azoospermia non obstruct azoospermia noa serious caus male infertil sertoli cell respond androgen take role support spermatogenesi may caus infertil work aim enhanc genet diagnosi noa via discoveri new hub gene implic human noa better assess odd success sperm extract accord individu genotyp whole exom sequenc wes done three noa patient find key gene involv noa evalu genom wide transcript transcript microarray sertoli non obstruct azoospermia normal cell microarray analysi three human case differ non obstruct azoospermia reveal gene upregul express gene downregul versus normal case purpos enrich shini go string cytoscap onlin evalu appli predict function molecular interact protein recogn master pathway function enrich analysi demonstr biolog process bp term inositol lipid mediat signal posit regul transcript rna polymeras ii posit regul dna templat transcript signific chang upregul differenti express gene deg bp investig downregul deg highlight mitot cytokinesi regul protein contain complex assembl cytoskeleton depend cytokinesi peptid metabol process overrepres molecular function mf term upregul deg includ ubiquitin specif proteas bind proteas bind phosphatidylinositol trisphosph phosphatas activ clathrin light chain bind interest mf analysi downregul deg reveal overexpress atpas inhibitor activ glutathion transferas activ atpas regul activ find suggest gene interact hub protein could help determin pathophysiolog germ cell abnorm infertil
|
D053713
|
T047
|
36,293,428
|
molecular mechan liver fibrosi potenti therapi applic liver fibrosi result repeat persist liver damag start hepatocyt injuri advanc inflamm recruit activ addit liver immun cell lead activ hepat stellat cell hscs primari sourc myofibroblast mfs result collagen synthesi extracellular matrix protein accumul although fda ema approv anti fibrot drug antivir therapi made remark progress prevent even revers progress liver fibrosi strategi remain elus patient viral alcohol nonalcohol steatosi genet autoimmun liver diseas due complex etiolog combin treatment affect two target like requir review pathogen mechan liver fibrosi signal pathway involv well various molecular target liver fibrosi treatment develop effici drug deliveri system target differ cell liver fibrosi therapi also summar highlight promis anti fibrot event clinic trial preclin test includ small molecul natur compound last discuss challeng opportun develop anti fibrot therapi
|
D008103;D008107
|
T033;T047
|
36,293,427
|
begin meiosi mammalian femal germ cell never end stori intrins extrins factor meiosi uniqu divis germ cell result recombin matern patern genom product haploid gamet mammal begin fetal life femal puberti male case enter meiosi requir time switch mitot meiotic cell cycl transit potenti pluripot status meiotic differenti reveal molecular mechan under interrel process repres essenc understand begin meiosi meiosi facilit divers across individu act fundament driver evolut major differ sex among speci complic understand meiosi begin basic meiotic research hinder current lack meiotic cell line recent part overcom use primordi germ cell like cell pgclcs generat pluripot stem cell much know process depend data model organ name mous mice process howev appear differ mani aspect human identifi mechan molecul control germ cell enter meiosi repres still repres major challeng reproduct medicin fact proper execut meiosi essenti fertil maintain integr genom ensur normal develop offspr main clinic consequ meiotic defect infertil probabl increas suscept type germ cell tumor present work report discuss data main concern begin meiosi mammalian femal germ cell refer process male pertin brief account process mice human histor chronicl major hypothes progress topic recent result review discuss
|
D008540;D039904
|
T025;T043
|
36,293,426
|
studi detect oleuropein extra virgin oliv oil use enzymat biosensor oleuropein oleu import indic qualiti authent extra virgin oliv oil evoo electrochem sensor biosensor detect oleuropein use test adulter extra virgin oliv oil present studi aim qualit quantit determin oleuropein commerci evoo sampl appli electrochem techniqu cyclic voltammetri cv squar wave voltammetri swv sens devic use two newli construct enzym biosensor support singl layer carbon nanotub modifi carbon screen print electrod speswcnt whose surfac tyrosinas speswcnttyr laccas speswcntlac immobil respect activ surfac two biosensor analyz character differ method cyclic voltammetri cv electrochem imped spectroscopi ei fourier transform infrar spectroscopi ftir result confirm effici immobil enzym speswcnttyr character low detect limit lod good sensit cm wide linear rang process occur biosensor surfac correspond kinet h tyrosinas show high affin toward oleu tyrosinas base biosensor shown superior sensit properti laccas base one quantit determin oleu evoo perform use speswcnttyr result confirm presenc compound close amount evoo analys prove good sensori properti
|
D037742;D015374
|
T104;T059;T073;T075
|
36,293,425
|
identif novel de novo variant casz caus rare type dilat cardiomyopathi new de novo frameshift variant identifi casz gene lead sever dilat cardiomyopathi
|
D002311
|
T047
|
36,293,424
|
legumain activ control extend activ site residu substrat conform legumain lysosom cystein proteas strict specif cleav asparagin residu sequenc comparison legumain belong merop clan cd cystein proteas indic structur mechanist relat caspas contrast caspas legumain harbor ph depend ligas activ addit proteas activ although alreadi signific bodi knowledg catalyt activ legumain mani mechanist detail still elus studi provid evid extend activ site residu substrat conform steer legumain activ biochem experi bioinformat analysi show catalyt cys residu regul steric close glu ser asn residu glu serv activ brake ser asn favor effect legumain proteas activ mutagenesi studi use caspas model enzym addit show similar glu activ brake also implement caspas furthermor show substrat conform flexibl determin whether hydrolyz ligat legumain function understand extend activ site residu substrat prerequisit allow us engin proteas increas enzymat activ better ligas substrat relev biotechnolog applic
|
D001216;D020169
|
T123;T126;T116
|
36,293,423
|
comprehens compar analysi develop molecular marker dianthus speci base complet chloroplast genom sequenc dianthus spp genus high econom ornament valu caryophyllacea includ famous fresh cut carnat tradit chines herbal medicin superbus despit dianthus speci seen everywher daili live genom inform phylogenet relationship remain elus thus perform assembl annot chloroplast genom individu seven dianthus speci basi carri first comprehens systemat analysi chloroplast genom sequenc characterist phylogenet evolut dianthus chloroplast genom dianthus individu rang bp bp contain function gene sequenc repetit analysi show number simpl sequenc repeat ssrs rang tandem repeat rang pair dispers repeat rang next calcul synonym nucleotid substitut rate ks protein code gene obtain evolut rate code gene dianthus speci rpl show highest ks suggest evolv swiftest reconstruct phylogenet relationship within dianthus speci caryophyllal dianthus individu individu report studi four individu download ncbi divid two strong support sister clade clade clade b clade contain five speci name caryophyllus barbatus gratianopolitanus two cultivar hy wc clade b includ four speci superbus sister branch chinensi longicalyx f hybrid offspr f chinensi hy base sequenc diverg analysi hypervari region analysi select sever region diverg sequenc develop dna marker addit found one dna marker use differenti clade clade b dianthus taken togeth result provid use inform understand dianthus classif chloroplast genom evolut
|
D054628;D029749;D004365
|
T121;T123;T002;T028
|
36,293,422
|
identif kfb famili moso bamboo reveal potenti function pekfb involv stress respons lignin polymer kelch repeat f box kfb protein import e ubiquitin ligas demonstr perform import post translat regulatori role plant mediat multipl biolog process despit import kfbs yet identifi character bamboo studi pekfb identifi f box kelch domain gene encod pekfb uneven distribut across chromosom moso bamboo phylogenet analysi indic pekfb divid eight subclad base similar gene structur high conserv motif tissu specif gene express analysi show pekfb differenti express various tissu moso bamboo promot pekfb contain stress relat cis element support differenti express pekfb moso bamboo drought cold stress sixteen protein screen moso bamboo shoot cdna librari use pekfb bait yeast two hybrid yh assay moreov pekfb physic interact peskp like peprx mediat activ peroxidas proteolyt turnov taken togeth find improv understand pekfb especi respons stress laid foundat reveal molecular mechan pekfb regul lignin polymer degrad peroxidas
|
D008031;D018506
|
T045;T123;T109
|
36,293,421
|
evalu proteom lipidom chang aeromona infect trout kidney tissu use ft ir spectroscopi maldi mass spectrometri imag aeromona speci opportunist bacteria caus vast spectrum human diseas includ skin soft tissu infect mening endocard periton gastroenter final hemorrhag septicemia aim research indic molecular alter protein lipid profil result aeromona sobria salmonicida subsp salmonicida infect trout kidney tissu sampl success appli ft ir fourier transform infrar spectroscopi maldi msi matrix assist laser desorptionion mass spectrometri imag monitor chang structur composit lipid secondari conform protein provid use inform concern diseas progress find indic follow spectral band absorb ratio spectral biomark use discrimin healthi tissu patholog alter tissu exampl lipid ch ch amid iamid ii amid ich amid ich spectral data obtain singl measur specimen indic numer abnorm concern protein lipid phospholipid induc aeromona infect suggest signific disrupt cell membran moreov increas content lysolipid lysophosphosphatidylcholin observ result studi suggest applic method maldi msi ft ir accur method profil biomolecul identifi biochem chang kidney tissu progress aeromona infect
|
D000081362;D000333
|
T007;T091;T109
|
36,293,420
|
synthesi anticanc antivir activ c branch arabinonucleosid arabinofuranosyl pyrimidin purin nucleosid analogu contain alkylthio acetylthio thiosugar substitu c posit prepar correspond silylen acet protect nucleosid exomethylen photoiniti radic mediat hydrothiol reaction although stereochem outcom hydrothiol depend structur thiol furanosid aglycon general high arabino select obtain cytotox effect arabinonucleosid studi tumor scc mous squamous cell immort control hacat human keratinocyt cell line mtt assay three pyrimidin nucleosid contain c butylsulfanylmethyl acetylthiomethyl group show promis cytotox low micromolar concentr good select toward tumor cell sar analysi use methyl arabinofuranosid refer compound show silyl protect group nucleobas correspond c substitu crucial cell growth inhibitori activ effect three activ nucleosid analogu paramet indic cytotox cell size divis time cell generat time investig near infrar live cell imag show acetylthiomethyluridin deriv induc signific function morpholog chang nucleosid analogu also exert anti sar cov andor anti hcov e activ low micromolar ec valu howev antivir activ alway accompani signific cytotox
|
D054330;D000086382;D011741
|
T047;T114;T067;T109
|
36,293,419
|
bergamottin pap induc ace degrad allevi infect sar cov angiotensin convert enzym ace function receptor sar cov appear like mediat ncov entri human cell howev inhibitor pap bergamottin discov preferenti bind ace prevent rbd spike protein bind ace reduc bind site rbd spike protein addit investig bind energi pap bergamottin ace molecular dock bio layer interferometri bli found relat high bind affin kd nm nm pap bergamottin group addit nanomolar fraction effect growth ii cell pap bergamottin inhibit prolifer ii cell vitro respect meanwhil signific reduc ace mrna protein respect result indic psoralen compound pap bergamottin bind ace protein could develop fight covid infect current pandem howev attent paid damag human alveolar type ii epitheli cell
|
D000086382;D011564
|
T121;T047;T067;T109
|
36,293,418
|
correl phenotyp genotyp ctnnb syndrom systemat review literatur ctnnb syndrom rare neurodevelopment disord associ development delay intellectu disabl delay absent speech aim present studi systemat review avail data preval clinic manifest evalu correl phenotyp genotyp publish case patient ctnnb syndrom studi identifi systemat search four major databas inform collect patient genet mutat prenat neonat problem head circumfer muscl tone eeg mri result dysmorph featur eye abnorm earli develop languag comprehens behavior characterist addit clinic problem addit mutat classifi five group accord sever symptom studi show wide genotyp phenotyp variabl patient ctnnb syndrom common moder sever phenotyp manifest facial dysmorph microcephali various motor disabl languag cognit impair behavior abnorm eg autist like aggress behavior nonsens missens mutat occur exon classifi normal clinic outcom categorygroup present otherwis normal phenotyp except eye abnorm milder phenotyp also observ missens nonsens mutat exon autosom domin ctnnb syndrom encompass wide spectrum clinic featur rang normal sever mutat general categor locat general observ c termin protein region exon correl milder phenotyp
|
D008607;D005124
|
T019;T048
|
36,293,417
|
composit structur modif ion beam graphen oxid radiat detect studi present studi graphen oxid foil thick irradi vacuum use charg state one charg state ion proton helium oxygen ion energi mev fluenc ioncm ioncm structur chang generat ion energi deposit investig x ray diffract suggest generat new phase reduc go go quantum dot graphit nanofib carbon nanotub amorph carbon stack cup carbon nanofib analys base rutherford backscatt spectrometri elast recoil detect analysi indic reduct go connect atom number implant ion morpholog chang ion irradi go foil monitor transmiss electron atom forc scan electron microscopi present studi aim better structur composit morpholog character go foil irradi differ ion condit low ion fluenci valid use go radiat detect propos promis dosimet observ go quantum dot produc go foil irradi proton helium oxygen ion number increas atom number beam gaseous ion
|
D011522;D037742
|
T104;T196;T073
|
36,293,416
|
clean label cure meat effect replac nitratesnitrit nutrient bioaccess peptid format cellular toxic vitro digest salami cure salt compos mixtur nitrat nitrit preserv wide use process meat despit mani desir technolog effect use meat product link methemoglobinemia format nitrosamin therefor increas anti nitrit feel grown among meat consum search clean label product view use natur compound altern repres challeng meat industri process includ formul ferment induc chemic physic chang food matrix modifi bioaccess nutrient format peptid impact real nutrit valu food studi investig effect nitratenitrit replac combin polyphenol ascorb nitrat reduc microbi starter cultur bioaccess fatti acid hydrolysi protein releas bioactiv peptid vitro digest moreov digest salami formul investig impact cell prolifer genotox human intestin cellular model ht cell line result indic replac synthet nitratesnitrit natur addit repres promis strategi develop innov clean label salami without negat affect nutrit valu
|
D008461;D009602
|
T168;T131;T109
|
36,293,415
|
graphen quantum dot modifi upconvers nanoparticl photodynam therapi photodynam therapi pdt novel techniqu extens employ cancer treatment util reactiv oxygen speci ros kill malign cell howev photosensit pss short ros yield affect therapeut effect pdt thus substanti demand develop novel pss pdt advanc clinic translat studi put forward new strategi ps synthesi via modifi graphen quantum dot gqds surfac rare earth element dope upconvers nanoparticl ucnp produc ucnp gqds core shell structur new type pss combin merit ucnp gqds produc ros effici near infrar light excit trigger pdt process ucnp gqds exhibit high biocompat obvious concentr depend pdt effici shed light nanomateri base pdt develop
|
D010778;D006108;D045663;D053758
|
T061;T196;T073;T109
|
36,293,414
|
discoveri new phenylaceton monooxygenas variant develop substitut indigoid biocatalysi indigoid natur pigment obtain plant ancient cultur roman use main dye wherea asian cultur appli compound treatment agent sever diseas modern era chemic industri made possibl identifi develop synthet rout obtain petroleum deriv howev process requir high temperatur pressur larg amount solvent acid alkali agent thus enzym engin develop bacteria whole cell biocatalyst emerg promis green altern avoid use hazard materi consequ prevent toxic wast generat research obtain two novel variant phenylaceton monooxygenas pamo iter satur mutagenesi heterolog express two enzym call pamo hpcd pamo hped e coli serendipit found produc indigoid interest result encourag us character thermal stabil enzym kinet new variant evalu indigo indirubin product whole cell system hplc highest yield obtain pamo hpcd supplement l tryptophan produc mgl indigo mgl indirubin addit enzym could oxid produc sever indigo deriv substitut indol pamo hpcd abl produc well known tyrian purpl result indic pamo variant describ herein potenti applic textil pharmaceut semiconductor industri prompt use environment friend strategi obtain divers varieti indigoid
|
D006899;D010578
|
T126;T116;T109
|
36,293,413
|
improv fmoc solid phase synthesi human beta defensin human defensin hbd residu antimicrobi immunomodulatori peptid play multipl role host defens system addit interact cell membran hbd also ligand melanocortin receptor cytokin receptor voltag gate potassium channel structur function studi hbd hamper ineffici synthet recombin express method herein report optim fmoc solid phase synthesi peptid use orthogon disulfid bond format strategi result suggest util optim resin coupl reagent pseudoprolin dipeptid build block decreas chain aggreg larg improv amount target peptid final crude materi make synthesi effici also present altern synthesi hbd replac nativ disulfid bridg diselenid bond improv oxid fold work enabl biolog pharmacolog character hbd henc advanc understand therapeut potenti
|
D023083;D024642
|
T123;T116
|
36,293,412
|
cytotox cell express leukocyt associ immunoglobulin like receptor lair viral hepat c mediat hepatocellular carcinoma virus relat hepatocellular carcinoma hcc pathogenesi involv liver inflamm therefor despit success treatment hepat c virus hcv may progress hcc initi liver cirrhosi cytotox cell tcs known involv hcv relat cirrhot complic hcc pathogenesi inhibitori checkpoint leukocyt associ immunoglobulin like receptor lair express tcs therefor aim determin whether tc express level lair associ hcc progress evalu lair express noninvas biomark hcc progress context liver cirrhosi relat hcv genotyp g egyptian patient peripher venous blood liquid biopsi total patient hcc patient liver cirrhosi enrol case control studi lair express tc relat progress liver cirrhosi examin compar appar healthi control group n lair express analyz use flow cytometri result hcc group signific higher lair express tc percentag tc posit lair lair tc hcv g relat liver cirrhosi group lair tc correl hcc surrog tumor marker afp r p insulin resist inflamm prognost ratiosindic receiv oper characterist roc curv reveal ad lair tc afp distinguish hcc transform egyptian patient cohort upregul lair express tc could potenti screen noninvas molecular marker chronic inflammatori hcv g relat liver cirrhosi moreov lair express tc may one player involv progress liver cirrhosi hcc
|
D006528;D008113;D006526;D019698
|
T047;T191
|
36,293,411
|
relationship neurogli apoptosi neuroinflamm epilept focus brain blood patient drug resist epilepsi neurogli apoptosi neuroinflamm play import role epileptogenesi aim studi evalu neuron glial apoptosi associ neuroinflamm brain epilept focus inflammatori chang blood patient focal drug resist epilepsi dre patholog chang tempor lobe epilepsi histolog transmiss electron microscopi level apoptot neuroinflammatori protein activ caspas immunohistochemistri full length form caspas caspas fas fas l nf kb tnf p western blot cytokin level blood il il il il tnf etc multiplex analysi studi present work ultrastructur immunohistochem apoptot sign found neuron oligodendrocyt tempor lobe dre patient level proinflammatori cytokin play role apoptosi tnf fas nf kb increas blood concentr il il tnf increas il reduc oligodendrogli apoptosi shown play import role dre pathogenesi explain demyelin thus comprehens analysi reveal chang blood brain dre patient show neuroinflamm epilept focus combin develop apoptosi glial cell neuron creat condit develop drug resist epilepsi progress
|
D004827;D000069279
|
T033;T047
|
36,293,410
|
physiolog base pharmacokinet model nanoparticl biodistribut review exist model simul softwar data analysi tool cancer treatment pharmaceut develop requir target treatment less toxic therapeut intervent achiev real progress diseas scenario nanomedicin emerg reliabl tool improv drug pharmacokinet translat clinic biolog base larg molecul howev abil bodi recogn foreign object togeth carrier transport heterogen deriv combin particl physic chemic properti payload surfac modif make design effect carrier difficult scenario physiolog base pharmacokinet model help design particl eventu predict abil reach target treat tumor effort perform scientist specif expertis skill familiar artifici intellig tool advanc softwar usual cord tradit medic materi research goal review highlight advantag comput model could provid nanomedicin bring togeth scientist differ background portray simpl way work comput develop descript tool use predict nanoparticl transport tumor target bodi
|
D053758;D009369;D001688
|
T121;T123;T191;T073
|
36,293,409
|
effect exercis train mitochondri function cardiovascular diseas systemat review meta analysi mitochondria dysfunct implic pathogenesi cardiovascular diseas cvd exercis train potenti effect non pharmacolog strategi restor mitochondri health cvd howev exercis modifi mitochondri function inconclus conduct systemat review use pubm scopus web scienc databas investig effect exercis train mitochondri function cvd patient search term includ mitochondria exercis aerob capac cardiovascular diseas vari combin search yield record abstract screen articl met inclus criteria summar effect exercis train mitochondri morpholog biogenesi dynam oxid capac antioxid capac qualiti amongst paramet oxid capac suitabl meta analysi demonstr signific effect size exercis improv mitochondri oxid capac cvd patient smd ci p lt high heterogen among studi p notabl aerob exercis enhanc succin involv oxid phosphoryl major result suggest exercis improv morpholog biogenesi wherea find dynam antioxid capac qualiti inadequ inconclus random control trial clear requir explain exercis modifi pathway mitochondri quantiti qualiti cvd patient
|
D000975;D002318
|
T123;T121;T039;T044;T047
|
36,293,408
|
exogen nitric oxid allevi damag caus tomato yellow leaf curl virus tomato regul peptidas inhibitor gene tomato yellow leaf curl virus tylcv causal agent one sever diseas affect tomato growth howev nitric oxid mediat plant resist studi investig molecular mechan exogen donor mediat diseas resist tomato seedl tomato seedl treat sodium nitroprussid tylcv subject phenotyp transcriptom physiolog analys result show exogen signific reduc diseas index mda content virus content signific increas stem length fresh weight diseas plant p lt improv photosynthesi induct effect studi found reduct virus content caus increas express peptidas inhibitor gene main reason increas resist tomato peptidas inhibitor inhibit proteas activ restrain virus synthesi signific reduct virus content inevit caus partial weaken shutdown diseas respons process diseas plant addit exogen also induc superoxid dismutas peroxidas activ fatti acid elong resist protein lignin monoterpen synthesi improv resist summari exogen enhanc resist tomato main regul peptidas inhibitor gene
|
D018551;D053839
|
T168;T005;T002
|
36,293,407
|
genom wide identif agc protein kinas gene famili relat photosynthesi rice oryza sativa camp depend protein kinas cgmp depend protein kinas g phospholipid depend protein kinas c agc perform various function plant involv growth immun apoptosi stress respons agc gene famili well describ arabidopsi howev limit inform provid agc gene rice import cereal crop research studi agc gene famili aa genom speci oryza sativa ssp japonica oryza sativa ssp indica oryza nivara oryza rufipogon oryza glaberrima oryza meridionali oryza barthii oryza glumaepatula oryza longistaminata search classifi six subfamili found speci similar number member analysi gene duplic select pressur indic agc gene famili expand main segment whole genom duplic wgd purifi select long evolutionari period rna seq analysi reveal osagc subfamili v specif high express leav express pattern gene compar photosynthesi relat gene use qrt pcr discov osagc osagc osagc might particip photosynthesi result provid inform perspect explor evolutionari agc gene famili practic applic rice
|
D012275
|
T168;T002
|
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