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biomedical-topic-categorization-validation

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36.4M
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36,279,243
actin architectur steer microtubul activ cytoskelet composit motil assay use surfac immobil molecular motor propel cytoskelet filament wide use character motor properti impact cytoskelet self organ moreov motil assay promis class bioinspir activ tool nanotechnolog applic assay involv control filament direct speed either sensori readout function featur design subtl control embed assay ongo challeng investig interact glide microtubul network actin filament demonstr microtubul behavior depend actin architectur unbranch branch actin deceler microtubul glide howev unbranch actin network provid addit guidanc effect steer microtubul effect resembl recognit cortic actin microtubul conceptu new mean control filament glide potenti applic design activ materi cytoskelet nanodevic
D000199;D008870
T026;T123;T116
36,279,220
chang cognit exposur phase cognit behavior therapi autist youth anxieti disord evalu improv cognit b exposur therapi phase cognit behavior therapi cbt autist youth anxieti disord
D001321;D015928
T061;T048
36,279,219
tempor explor interperson theori suicid among adolesc treatment interperson theori suicid predict perceiv burdensom thwart belonging hopeless lead suicid ideat recommend burdensom belonging target treatment limit research test burdensom belonging tempor predict suicid ideat treatment studi examin bidirect relationship burdensom belonging hopeless depress suicid ideat young peopl seek treatment suicid relat behavior
D007398;D013405
T033;T055;T054;T080
36,279,218
adolesc well suit app base mind train random clinic trial data driven approach person recommend rumin heighten risk depress anxieti increas substanti adolesc smartphon app offer conveni cost effect mean adolesc access mind train may reduc rumin despit increas popular unclear adolesc benefit mind app
D064866;D063731
T170;T041
36,279,217
au surrog f case uau vs uf anion photoelectron spectroscopi first principl quantum chemistri use demonstr degre au act surrog f uf anion unlik uf uau exhibit strong ligand ligand ie au au interact result three low lie isom two three dimension third isom ring like quasi two dimension structur addit uau isom open shell electron near case local central u atom adiabat electron affin vertic detach energi measur ev respect good agreement calcul
D004583
T081;T196
36,279,172
understand design implement onlin consult affect primari care qualiti systemat review evid recommend design provid research onlin consult oc allow patient contact care provid web worldwid oc roll primari care rapid owe polici initi covid lack evid regard oc design implement influenc care qualiti
D000086382
T047;T067
36,279,171
digit biomark base studi scope review systemat review sensor digit devic revolution measur collect storag behavior physiolog data lead new term digit biomark
D015415
T201;T080
36,279,168
halogen uridin suppress proton induc tautomer enhanc glycosid bond stabil proton uridin investig via irmpd action spectroscopi er cid experi theoret calcul uridin urd canon nucleosid rna common modifi nucleosid among occur natur uridin also import target develop modifi nucleosid analogu pharmaceut applic work effect halogen uracil structur glycosid bond stabil proton uridin nucleosid analogu examin use tandem mass spectrometri comput method infrar multipl photon dissoci irmpd action spectroscopi experi theoret calcul perform probe structur influenc modif energi resolv collis induc dissoci experi along surviv yield analys perform probe glycosid bond stabil measur irmpd spectra compar linear ir spectra predict stabl low energi conform speci comput blyp g p level theori determin conform experiment popul spectral signatur ir fingerprint hydrogen stretch region allow dihydroxi proton tautom proton conform readili differenti comparison measur predict spectra indic parallel find uridin proton conform halouridin nucleosid analogu popul wherea proton conform variat yield spectral signatur characterist proton conform indic extent proton induc tautomer suppress size halogen substitu increas trend energi depend surviv yield curv find halogen strengthen glycosid bond enhanc stabil increas size halogen substitu
D009705;D054879
T121;T070;T067;T114;T068
36,279,164
visual techniqu time orient data comparison singl patient multipl patient cohort scope review visual analysi data deliveri form visual great import health care form present reduc error improv care also help provid new insight long term diseas progress inform visual visual analyt also address complex long term time orient patient data reduc inher complex facilit focus under hidden pattern
D057189;D003695
T058;T170;T093
36,279,159
long term effect use step count specif smartphon app physic activ weight loss random control clinic trial studi weight loss promot use smartphon app shown weight loss effect increas physic activ howev long term effect smartphon app weight loss increas physic activ rigor examin date
D063731
T170
36,279,158
neural dynam causal infer macaqu frontopariet circuit natur percept reli inher infer causal structur environ howev neural mechan function circuit essenti repres updat hidden causal structur correspond sensori represent multisensori process unknown address monkey train infer probabl potenti common sourc visual propriocept signal base spatial dispar virtual realiti system propriocept drift report monkey demonstr combin previous experi current multisensori signal estim hidden common sourc subsequ updat causal structur sensori represent singl unit record premotor pariet cortic reveal neural activ premotor cortex repres core comput causal infer character estim updat likelihood integr multipl sensori input trial trial level respons signal premotor cortex neural activ pariet cortex also repres causal structur dynam updat sensori represent maintain consist causal infer structur thus result indic premotor cortex integr previous experi sensori input infer hidden variabl select updat sensori represent pariet cortex support behavior dynam loop frontal pariet interact causal infer framework may provid neural mechan answer long stand question regard neural circuit repres hidden structur bodi awar agenc
D008251;D009044
T023;T015;T029
36,279,157
effect use patient access electron health record portal cancer survivor health outcom cross section survey studi past decad patient access electron health record paehr system emerg import tool health manag hospit level individu level howev littl known effect paehr portal survivorship patient chronic health condit eg cancer
D000073116;D000072638;D009369
T201;T170;T191;T101
36,279,149
overcom preclin safeti obstacl discov n hexahydro indacen yl carbamoyl methylamino dihydro h pyrazolo b oxazin sulfonamid gdc potent select nlrp inhibitor inappropri activ nlrp inflammasom implic multipl inflammatori autoimmun diseas herein aim develop novel nlrp inhibitor could minim risk drug induc liver injuri lipophil ligand effici use guid metric identifi seri dihydro h pyrazolo b oxazinesulfonylurea lead compound seri advanc safeti studi cynomolgus monkey renal toxic due compound precipit observ overcom obstacl focus improv solubl compound specif introduc basic amin substitu scaffold led identif gdc potent select nlrp inhibitor vitro vivo safeti profil suitabl advanc human clinic trial
D000071199;D010078
T123;T116;T109
36,279,145
associ parent depress children intern extern problem meta analys cross section longitudin effect meta analys use test associ parent depress child intern extern problem base cross section longitudin effect parent child pair studi publish
D003863;D005190
T184;T099;T062;T079;T054;T048
36,279,139
associ smoke smoke cessat mortal race ethnic sex among us adult pattern cigarett smoke smoke cessat vari consider across demograph group us limit evid whether hazard smoke benefit quit vari across group popul specif evid benefit quit smoke may motiv cessat among group histor underrepres medic research
D016540;D000073865
T055
36,279,138
associ video game cognit perform among children although research link video game subsequ increas aggress behavior children account prior aggress find divid respect video game associ cognit skill
D018910
T073
36,279,137
endovascular therapi vs medic manag patient acut stroke medium vessel occlus anterior circul random clinic trial shown efficaci endovascular therapi evt acut larg vessel occlus stroke benefit evt acut stroke distal medium vessel occlus dmvo remain unclear
D057510;D020521
T061;T047
36,279,136
experi prenat care deliveri report black patient low incom health care worker us qualit studi black pregnant peopl low incom face inequ health care access outcom us yet voic larg absent redesign prenat care
D011295;D010166
T061;T058
36,279,135
comparison germlin genet test medic polici cover univers test among patient colorect cancer health insur plan updat medic polici cover germlin genet test patient diagnos colorect cancer crc guidelin univers tumor screen via microsatellit instabl andor immunohistochemistri msiihc mismatch repair protein express patient crc place sinc
D003123
T047;T191
36,279,134
effect guidelin inform clinic decis support system intervent improv coloni stimul factor prescrib cluster random clinic trial coloni stimul factor prescrib patient undergo chemotherapi reduc risk febril neutropenia research suggest coloni stimul factor prescrib inconsist nation guidelin
D003115;D020000;D064147;D009369
T123;T116;T191;T170;T058;T047
36,279,133
effect electron health record clinic decis support contextu care random clinic trial contextu care process incorpor inform life circumst behavior individu patient term contextu factor plan care step clinician recogn clue term contextu red flag clinician ask probe context patient disclos contextu factor clinician adapt care accord process associ desir outcom resolut present contextu red flag
D057286;D020000
T058;T170;T073
36,279,132
implement assess resid divers council address need divers clinic workforc minorit racial ethnic group remain underrepres medicin uim compar general popul although mani resid program want train divers group individu method implement fulli establish
D006280;D007396
T081;T065;T097
36,279,114
reform world health organ essenti medicin list essenti unafford viewpoint propos restructur essenti medicin list remov consider cost cost effect expert committe review clinic effect safeti public health valu charter new framework pool global negoti procur cost medicin includ list
D018954
T121
36,279,108
one pot synthesi effici multifunct nitrogen dope carbon dot effici yellow fluoresc emiss detect hypochlorit thiosulf cd base ratiometr fluoresc probe great signific visual detect accomplish goal still particular challeng task herein nitrogen dope carbon dot ncds bright yellow fluoresc easili manufactur via one pot hydrotherm method visual detect hypochlorit clo thiosulf uv light irradi prepar ncds demonstr favor water solubl excel biocompat superior optic properti low cytotox strike fluoresc ncds could quench clo base result origin fluoresc nanoprob construct high discrimin recognit clo oxid amino group surfac nitro group assay cover rang limit detect sn low remark grow peak appear nm emiss nm shrink introduct demonstr ratiometr fluoresc emiss characterist f nm f nm rang limit detect sn low addit fluoresc color ncds also chang yellow green blue ad various clo concentr fluoresc color ncds clo also chang blue green yellow ad various concentr excel ratiometr fluoresc probe success use nuclear imag accord easi prepar paper base sensor identifi clo fabric demonstr adapt situ site test research open new opportun develop effici yellow fluoresc probe base ncds nanomateri visual detect biomark biomed optic imag
D045663;D015374
T059;T073;T075
36,279,079
field studi ion analysi model kashan plain aquif predict sourc salin shortag freshwat salin consid two major develop problem arid semi arid region growth popul develop industri agricultur climat chang caus extract groundwat resourc consequ qualiti quantiti groundwat decreas especi arid semi arid area present studi investig reason salin kashan aquif studi observ well locat aquif examin qualit studi total sampl collect select well period year analyz chemic paramet electr conduct ec ph total dissolv solid tds sodium na potassium k calcium ca magnesium mg chlorin cl bicarbon hco groundwat tabl studi show direct groundwat flow throughout aquif often west east aquif except northeastern part aquif backflow northeast salt lake aquif visibl result ion analysi differ area aquif indic occurr upcon phenomenon center south region occurr salin water intrus phenomenon northeast region simul condit kashan aquif next year model quantiti qualiti aquif develop use seawat code accord result salin kashan plain aquif occur due two main reason irregular groundwat extract upcon phenomenon intrus salin water salt lake toward aquif kashan aquif salin forecast result show continu current pump activ next year increas number well affect salin consid critic situat kashan aquif exist serious threat serious decis measur proper manag groundwat aquif protect vital
D014874;D060587
T081;T131;T070;T082
36,279,050
subsurfac groundwat aquif map qualiti character matiari district sindh pakistan groundwat altern resourc use supplement irrig well drink purpos pakistan paper aim determin quantum qualiti groundwat matiari district sindh pakistan electr resist survey er er conduct locat point use abem terramet sas quantiti good qualiti groundwat also evalu arcgi interpol techniqu ie maximum percentag fresh groundwat margin fresh groundwat depth patch salin groundwat aquif moreov depth percentag fresh groundwat reduc margin increas howev groundwat depth found fresh groundwat margin salt water high salt water analysi groundwat sampl qualiti show good agreement qualiti obtain ves result addit socio econom survey tube well owner conduct interview relat groundwat suitabl usag accord survey respond use good qualiti groundwat howev consum margin remain util hazard qualiti groundwat consum satisfact survey show farmer satisfi groundwat usag unsatisfi due poor qualiti groundwat crop product could enhanc awar conjunct use margin qualiti groundwat canal water
D014874;D060587
T081;T131;T070;T082
36,279,048
appar preval risk factor bovin tuberculosi state paran brazil assess year sinc begin brazilian program bovin tuberculosi btb impact consider anim product one health worldwid describ preval risk factor spatial pattern diseas state paran brazil cross section studi conduct septemb februari area divid seven region within region farm random select predetermin number cow select test compar cervic tuberculin test anim test across farm herd preval btb infect herd paran vari among seven region cluster detect west central northeast area anim preval vari among pre set region major shift preval btb detect sinc larg size herd dairi product feed whey detect correl presenc btb exclus among dairi herd veterinari assist cooper possess self own equip cool milk feed whey correl diseas consid result recommend state paran seek implement surveil system detect btb infect herd transform free one possibl incorpor element risk base surveil health educ also recommend inform farmer risk introduc anim without test feed raw whey calv
D014380;D002418
T047
36,279,043
environment impact assess algal bloom noctiluca scintillan mandapam group island gulf mannar biospher reserv southeast coast india present investig account environment impact assess intens algal bloom caus dinoflagel noctiluca scintillan bloom first observ th septemb vicin mandapam group island spread rameswaram coast north n e hare island south n e coastal water around mandapam region appear dark green microscop examin water sampl reveal presenc n scintillan larg number n scintillan bioluminesc organ inflat sub spheric shape size organ rang micron intens period bloom averag densiti n scintillan record cellsl dissolv oxygen content low ammonia content extrem high certain site avg ml intens bloom may lead loss biodivers affect area region subsequ investig indic resili ecosystem respons natur advers
D010839;D004141
T204;T002
36,279,030
microplasticnanoplast toxic plant immin concern toxic impact microplasticsnanoplast mpsnps plant food chain recent becom top prioriti sever research articl highlight impact mpsnps aquat food chain howev littl done terrestri ecosystem number studi reveal mpsnps uptak subsequ transloc plant alter plant morpholog physiolog biochem genet properti vari degre howev research gap regard mpsnps entri plant associ factor influenc phytotox level potenti remedi plan term food safeti secur address issu sourc mpsnps intrus agroecosystem revis avoid hazard materi special consider prevent measur furthermor review focus rout accumul transmiss mpsnps plant tissu relat aspect influenc intens plant stress potenti solut improv food qualiti quantiti paper also conclud provid outlook approach appli exogen melatonin introduc engin plant would enhanc stress toler mpsnps addit overview inocul benefici microorgan encapsul enzym soil address would make degrad mpsnps faster
D008550;D014874
T125;T121;T131;T109
36,279,025
assess exposur pm differ lebanes microenviron differ tempor scale weak potenti use sole outdoor concentr repres person exposur pm confirm literatur therefor import account person movement time estim short term person air pollut exposur within differ microenviron mes studi exampl appli assess method exposur pm differ microenviron differ tempor scale low cost particl counter dylo use perform valid comparison equival instrument sidepak person aerosol monitor r valid also provid function convert measur particl number concentr pncs calcul particl mass concentr profil collect minut minut basi regard pm concentr decemb may highlight influenc individu activ contextu factor air qualiti lebanon annual pm mean gm higher world health organ annual mean guidelin gm winter pollut period due increas applic space heat devic addit occurr dusti wind spring period lead elev level dispers pm simultan rural zone pollut urban one due usag tradit heat equip addit usag chemic product like pesticid fertil agricultur activ area furthermor outdoor indoor transport mes indic transport indoor mes similar level suspend fine particul outdoor mes less pollut studi base person exposur pm general appli specif limit place school workplac resid studi aim shed light modern method attempt estim person exposur pm inspir similar studi achiev maximum effici
D000393;D016902;D010575
T131;T069;T080
36,279,024
potenti toxic element ptes gomti ganga alluvi plain associ human health risk assess potenti remedi use novel nanomateri health risk associ consumpt water river gomti pollut potenti toxic element ptes includ fe pb cd mn cr ni hg investig initi unlock covid lockdown compar pre covid lockdown status current investig total hazard index thi valu exceed accept limit uniti sampl station use river water drink domest purpos million peopl high thi valu emerg matter huge concern individu hazard quotient associ cd pb found sever vivid differ thi valu two studi phase indic posit impact covid lockdown signifi promin impact anthropogen activ pte concentr closur local manufactur unit textil batteri etc emerg potenti reason decreas health risk associ pte level higher suscept children health risk comparison adult valu thi hqs interpret across studi area potenti remedi measur pte contamin also suggest studi
D019216;D000086382;D008628;D049329;D012989
T073;T067;T131;T196;T047
36,279,023
pikca mutat breast cancer phosphatidylinositid kinas pik regul prolifer apoptosi somat pikca mutat may activ process aim studi determin preval pikca mutat cohort earli stage breast cancer patient associ cours diseas
D001943
T191
36,279,021
ground level ozon concentr forest urban environ central slovakia paper analys data summaris concentr valu ground level ozon glo studi area situat central slovakia part western carpathian measur carri implement werner method work passiv sampler highest averag highest absolut glo deposit valu ppb ppb respect record august forest kremnick vrchi mts lowest averag glo valu whole measur period ppb measur town zvolen absolut minimum ppb record april open plot kremnick vrchi mts glo format studi area yet reach steadi rate sinc development trend increas statist signific differ glo concentr confirm local differ airborn pollut howev analysi exist ozon concentr valu show consider differ especi relat time pattern spatial variabl equalis extrem valu remark danger especi forest stand kremnick vrchi mts time critic level ppb domin factor influenc glo concentr global radiat effect averag temperatur rainfal total less import
D010126;D000393
T131;T103
36,279,019
diurnal month season variat indoor radon concentr concern meteorolog paramet report turkish atom energi agenc former taek newli tenmak izmir provinc higher indoor radon concentr compar citi turkey sinc modern peopl spend daili time indoor import know indoor radon level long term variat howev knowledg indoor radon level izmir surround limit moreov inform area larg term variat indoor radon studi carri motiv indoor radon concentr meteorolog paramet measur offic teach staff univers build data collect hour month day raw data diurnal month season variat paramet investig separ result show averag indoor radon concentr bq relat lower nation intern refer valu indoor radon concentr show increas decreas trend throughout day radon concentr slight higher morn downtim earli hour day reduc afternoon relat daili routin usag offic affect ventil room air temperatur variat etc
D011886;D000396;D016902;D011834
T080;T131;T196;T059;T069
36,279,013
molecular imag brain heart axi provid insight cardiac dysfunct cerebr ischemia ischem stroke impart elev risk heart failur though under mechan remain poor describ aim character influenc cerebr ischem injuri cardiac function use multimod molecular imag investig brain cardiac morpholog tissu inflamm two mous model variabl stroke sever transient middl cerebr arteri occlus mcao generat extens stroke damag mm positron emiss tomographi imag inflamm target mitochondri transloc protein tspo reveal local neuroinflamm day stroke compar sham vs idg max p contrast parenchyma topic applic vasoconstrictor endothelin generat signific stroke damag neuroinflammatori cell activ mcao evok modest reduct left ventricl eject fraction week week stroke lvef week vs p contractil impair parallel elev cardiac tspo pet signal compar sham vs idg p independ leukocyt infiltr defin flow cytometri stroke size correl sever cardiac dysfunct r p statist parametr map identifi direct associ neuroinflamm day cluster voxel includ insular cortex reduc eject fraction p suppress microglia led lower tspo signal day correl spare late cardiac function mcao r p region neuroinflamm earli cerebr ischemia influenc subsequ cardiac dysfunct total bodi tspo pet enabl monitor neuroinflamm provid insight brain heart inter organ communic may guid therapeut intervent spare cardiac function post stroke
D002545;D006331;D020521
T047;T046
36,279,006
testosteron treatment male hypogonad congenit acquir disord exert negat influenc various organ function massiv impair qualiti life relat absolut defici testosteron varieti prepar avail substitut treatment differ administr form intak interv execut testosteron treatment various guidelin exist clear practic instruct indic contraind treatment procedur monitor particular import cardiovascular aspect diseas prostat gland underlin central posit urologist treatment
D013739;D007006
T125;T121;T047;T109
36,279,003
variat centenni precipit pattern kuwait relat climat chang impact climat chang could infer observ long term climat variabl like temperatur precipit evapotranspir local studi climat factor temperatur precipit co emiss popul carri temperatur record studi period reflect increas c higher global averag relationship climat factor statist analysi infer local factor influenc precipit kuwait show interrelationship among temperatur co emiss popul therefor kuwait precipit concern region atmospher process like sea surfac temperatur volcan erupt wind direct el nino la nina event studi pragmat chang wind direct kuwait northwest north enforc studi effect volcan erupt mount etna precipit kuwait mark correl precipit trend post erupt period mount etna observ similar el nino la nina event correl especi month temperatur total rainfal thus increas sea surfac temperatur volcan event influenc hadley cell circul shift intertrop converg zone affect rain event kuwait
D057231;D002245
T123;T197;T070
36,279,001
compar analysi low intens ultrasound effect live cell simul experi ultrasound alreadi broad exploit clinic diagnost becom power harm tool antitumor therapi abl produc damag toward cancer cell thank inerti cavit temperatur increas use us alon combin molecular compound microbubbl solid state nanoparticl focus current research clinic trial like thermoabl drug sonopor sonodynam therapi present work discuss non thermal effect ultrasound condit enabl oxygen radic product role provok death differ cancer cell line perspect set mathemat model predict pressur spatial distribut defin water sampl volum thus obtain map acoust pressur acoust intens appli ultrasound differ input power valid verifi numer result direct acoust measur detect product reactiv oxygen speci ros mean sonochemiluminesc scl electron paramagnet reson epr spectroscopi appli water sampl volum use us input paramet adopt simul final various us condit appli two differ set cancer cell line cervic adenocarcinoma hematolog cancer burkitt lymphoma hypothes ros generat influenc record cell death second set experi role semiconductor metal oxid nanocryst ie zinc oxid also evalu ad water biolog system particular role zno enhanc ros product verifi furthermor interplay among us zno nanocryst evalu provok cancer cell death specif condit studi demonstr use correl numer simul experiment acoust valid well ros measur qualit quantit level us irradi simpl water solut tri translat obtain result justifi one possibl mechan respons cancer cell death thus aim pave way use us cancer therapi better understand non thermal effect specif set us paramet cancer cell cultur vitro
D015034;D053758;D009369
T121;T197;T191;T073
36,279,000
impact sever postop inflammatori respons recurr curat resect colorect cancer relationship recurr system inflamm earli postop period colorect cancer crc unclear studi examin chang recurr risk result postop inflamm studi aim investig prognost impact sever postop inflammatori respons curat resect crc
D002097;D015179
T129;T191;T116
36,278,999
young onset colon cancer among peopl live hiv metropolitan atlanta colon cancer lead caus cancer relat morbid mortal usa sought better character colon cancer among predomin black cohort without hiv
D015658;D003110
T047;T191
36,278,998
updat cystic fibrosi neonat screen causal treatment cystic fibrosi cf multiorgan diseas caus mutat cystic fibrosi transmembran conduct regul cftr gene approxim morbid mortal caus pulmonari involv mean life expect patient cf year germani introduct neonat screen cf develop causal act cftr modul treatment clear improv prognosi patient introduct articl describ import aspect cf context order go detail cf neonat screen introduc germani
D019005;D003550
T123;T047;T116
36,278,976
practic use electron patient record find two care project center rare diseas electron patient record offer opportun digit network medic care provid digit communic health servic provid patient patient rare diseas benefit diagnosi treatment inform earli stage receiv precis treatment basi multiprofession case manag regard patient care medic research rare diseas electron patient record help collect data structur manner digit map workflow registr admiss diagnosi treatment reduc cost healthcar system diagnosi treatment target better patient unnecessari medic examin reducedin two pilot project first experi electron patient record patient rare diseas gather cooper sever medic care provid project base netz translat nams analyz requir electron patient record demonstr technic legal feasibl evalu practic medic care provid patient particip center rare diseas see benefit structur registr patient simplif cross institut patient manag patient fulfil task health profession easili share data develop telematikinfrastructur gematik offer opportun eas digit connect doctor offic center rare diseas particular constant clarif transpar essenti order provid inform data protect issu train support also provid promot patient digit skill
D057286;D035583
T047;T170;T073
36,278,975
artifici intellig diagnosi rare disord develop phenotyp analysi rare diseas often diagnos care assess phenotyp patient characterist deviat dysmorph occur mani genet diseas affect exampl featur face facial gestalt paper highlight area artifici intellig ai great progress recent year recognit characterist pattern medic imag data use deep convolut neural network next generat phenotyp ngp technic basi method briefli describ high relev fair data scientif communiti develop ai discuss furthermor explain decis made ai alway remain comprehens overcom challeng regard data protect transparencyin futur softwar applic ai support medic profession diagnosi rare diseas ai trustworthi patient retain data sovereignti understand diagnosi made
D001185;D035583
T090;T047;T073;T066
36,278,971
oxygen satur target critic ill adult receiv mechan ventil invas mechan ventil critic ill adult involv adjust fraction inspir oxygen maintain arteri oxygen satur oxygen satur target optim clinic outcom patient popul remain unknown
D012121;D016638
T061;T047
36,278,968
variat milk protein across lactat pongo pygmaeus gorilla gorilla milk critic nutrit sourc neonat mammal addit nutrit milk contain multitud bioactiv molecul like affect neonat physiolog metabol immun function suggest chang milk proteom across lactat reflect chang need neonat juvenil offspr use mass spectrometri character milk proteom pongo pygmaeus sampl gorilla gorilla sampl hous smithsonian nation zoo conserv biolog institut train give milk sampl found total protein p pygmaeus protein g gorilla specif character chang across lactat protein repres multipl compart milk includ milk fat globul membran whey addit character chang various immunoglobulin type find similar previous publish studi primat milk despit broad similar milk proteom two ape demonstr proteom sampl month cluster speciesindividu distinct sampl individu requir distinguish whether result demonstr speci differ individu differ studi repres baselin studi zoo base milk studi build raw data metamorpheus search result pawblast result avail massiv ftp massiveucsdedumsv
D006071;D011148
T015
36,278,967
prebiot vesicl retain solut grow micell addit brief cool membran melt temperatur replic rna genom within membran vesicl may critic step develop protocel earli earth cold temperatur near c improv stabil rna allow effici copi climat model suggest cold earli earth first protocel may arisen cold temperatur environ howev cold temperatur satur fatti acid would avail earli earth form gel phase membran rigid restrict mobil within bilay two primari role protocel membran encapsul solut grow incorpor addit fatti acid environ test whether fatti acid membran gel phase accomplish role find gel phase membran carbon amphiphil near c encapsul aqueous dye molecul effici fluid phase membran content releas aqueous solut frozen c gel phase membran grow measur micell addit growth resum membran warm gel liquid transit temperatur find longer carbon amphiphil retain encapsul content near c togeth result suggest protocel could develop within environ experi temporari cool membran melt temperatur membran compos relat short chain fatti acid would encapsul solut effici temperatur approach c
D008823;D003080
T070;T109
36,278,964
methylen blue remov use raw modifi biomass plumeria alba white frangipani batch mode isotherm kinet thermodynam studi hazard dye use textil industri consid high risk pollut environ raw well acid treat plumeria alba white frangipani leaf powder wflp swflp use adsorpt methylen blue mb avail industri wastewat follow batch adsorpt techniqu character adsorb done ftir sem edx tga zeta potenti paramet adsorpt consid effect temperatur initi dye concentr solut ph adsorb dosag contact time experiment result obtain adsorpt mb examin nonlinear error function like chi squar mpsd three isotherm model langmuir freundlich temkin maximum monolay adsorpt capac q max mgg mgg raw wflp mgg swflp adsorb fit pseudo second order kinet model r use experiment data batch adsorpt thermodynam studi explain spontan natur adsorpt raw acid treat adsorb batch experiment result character adsorb reveal select adsorb would best adsorb remov mb wastewat solut
D014874;D029062;D018508
T131;T052;T002;T057
36,278,959
design synthesi preclin activ ovarian cancer model new phosphanegold n heterocycl carben complex new seri seven gold complex contain bis diisopropylphenyl imidazol yliden ipr phosphan ligand l l synthes evalu antitumor activ ovarian cancer ovca model synthes complex character ir mass spectrometri nmr spectroscopi complex character xrd crystallographi antiprolif effect new complex found higher cisplatin auranofin ovca cell sensit resist cisplatin anticanc activ activ complex investig use ovca vitro model includ three dimension multicellular tumor spheroid vivo tumor xenograft cisplatin auranofin use compar purpos complex induc apoptosi mitochondri reactiv oxygen speci dna damag caus g phase cell cycl arrest inhibit proteasom activ cell migrat modifi actin polymer signific inhibit ovca murin xenograft promis result suggest preclin test complex futur applic
D000970;D010051;D056831
T121;T191;T104;T109
36,278,958
synthesi e z verbenon oxim ether photorespons behavior herbicid activ accumul residu activ herbicid environ caus seri problem thus meaning explor photorespons herbicid whose activ weaken action light reduc negat effect purpos seri e z verbenon oxim ether design synthes character oxim ether group adopt trigger switch preliminari screen herbicid activ show exhibit better compar effect commerci herbicid flumioxazin brassica campestri echinochloa crusgal meanwhil five pair target compound signific differ herbicid effect e z form investig revers isomer reaction accompani variat herbicid activ result maximum convers rate around herbicid effect result mixtur e z isom decreas outstand phototransform mechan pair isom e z preliminarili explor besid reason effect quantit structur activ relationship model r q establish bind mode also investig molecular dock
D006540
T131
36,278,954
one pot synthesi trifluoromethylbenzo b oxazin cf imidoyl sulfoxonium ylide bromophenol herein method access trifluoromethyl benzoxazin cf imidoyl sulfoxonium ylide bromophenol demonstr synthet protocol proceed via one pot two step sequenc includ lithium bromid promot h insert sulfoxonium ylide annul merit broad substrat scope excel function toler oper simplic provid altern mean obtain cf substitut heterocycl
D010078;D010636
T121;T109
36,278,950
hemilabil amin function effici azo aromat cu catalyst inspir galactos oxidas impact amin sidearm catalyt aerob oxid alcohol seri azo aromat copper ii complex g cu complex h vari amin function hemilabil pincer like hl l methyl substitut azo l imin l ligand synthes character complex investig aerob oxid varieti aromat alcohol presenc mol precatalyst g cobaltocen mol n methyl imidazol nmi mol tempoh mol room temperatur cu complex h act catalyst absenc cobaltocen understand mechan detail experiment theoret studi perform repres complex suggest new kind mechan involv cu ii cu redox coupl cobaltocen act reduct generat cu complex activ dioxygen presenc nmi tempoh transfer hydrogen atom activ dioxygen generat tempo particip c h bond activ cu ii alkoxid intermedi intermolecular fashion catalyt cycl amin sidearm ligand backbon complex signific role catalyt activ complex amin sidearm effect complex without moreov aliphat secondari amin sidearm effici among amin sidearm aromat secondari amin tertiari amin amin sidearm remain coordin cu ii center hemilabil facilit alcohol coordin catalyt process alcohol coordin rate limit step support isotop effect studi benzyl alcohol substitut effect amin moieti ligand dft calcul hemilabil amin sidearm coordin ligand also act base deproton alcohol h proton act acid releas h catalysi
D005692;D000438
T121;T126;T116;T109
36,278,939
molecular insight misfold dimer dynam full length synuclein atomist discret molecular dynam simul misfold patholog aggreg synuclein form insolubl amyloid deposit associ parkinson diseas second common neurodegen diseas world popul character self assembl mechan synuclein critic discov treatment synucleinopathi intrins disord properti high degre freedom macroscop timescal conform convers make character extrem challeng vitro silico systemat investig dynam monom misfold dimer full length synuclein use atomist discret molecular dynam simul result suggest synuclein monom dimer main adopt unstructur format partial helic around n terminus residu various sheet span residu n termin tail residu nac region c terminus most assum unstructur format wrap around later surfac elong edg sheet core form n termin tail nac region dimer enhanc sheet format along decreas unstructur content inter peptid sheet main form n termin tail nacor residu region suggest two region play critic role amyloid aggreg synuclein interact c terminus n termin tail nac region signific suppress synuclein dimer indic interact c terminus n termin tail nac region could prevent synuclein aggreg result structur ensembl earli aggreg dynam synuclein help understand nucleat fibril synuclein
D051844;D019636
T123;T047;T116
36,278,938
nontox concentr ochratoxin aggrav renal fibrosi induc adriamycincyclosporin nephropathi via tgf smad ochratoxin ota common contamin food feed caus nephrotox studi reveal low level ota contamin could also caus physiolog dysfunct chronic kidney diseas ckd becom import public health problem increas morbid howev potenti effect nontox ota ckd remain uncertain studi adriamycin adr cyclosporin csa use stimul glomerular nephropathi tubular nephropathi respect renal injuri aggrav due ota mgkg exposur mous nephropathi model assess renal histomorpholog detect blood urea nitrogen bun serum creatin scr level notic nontox dosag ota increas express fibrot factor smooth muscl actin sma vimentin nephropath mous indic exacerb adrcsa induc renal fibrosi conduct vitro experi glomerular mesangi cell renal tubular epitheli cell nontox concentr ota found exacerb cytotox adrcsa intensifi renal fibrosi activ tgf smad thus studi may provid convinc evid prevent ckd aggrav renew food hygien standard mycotoxin contamin
D016572;D051436
T121;T047;T116
36,278,936
compar studi coval van der waal cds quantum dot assembl mani bodi perturb theori quantum dot qd assembl nanostructur network made aggreg qds featur improv charg energi transfer effici compar discret qds use first principl mani bodi perturb theori systemat compar electron optic properti two type cds qd assembl experiment investig qd gel individu qds coval connect via di polysulfid bond ii qd nanocryst individu qds bound via van der waal interact work illustr electron optic properti evolv discret qds assembl gel nanocryst well one bodi mani bodi interact system impact trend dimension assembl increas furthermor work reveal crucial role di polysulfid coval bond local exciton highlight differ qd gel qd nanocryst
D045663;D053758
T073
36,278,935
improv glycoqueu strategi reveal novel link di tri sialyl oligosaccharid isom human milk sialyl human milk oligosaccharid shmos possess uniqu biolog activ qualit quantit analys shmos differ lactat stage limit interfer neutral oligosaccharid glycan structur complex low detect sensit herein previous develop glycoqueu strategi improv appli enabl isom specif quantit comparison shmos colostrum milk cm matur milk mm total putat structur determin includ link link isom separ seven newli discov shmo composit content oligosaccharid lower mm cm sialyl observ shmos cm shmos mm final fucosyl level shmos increas prolong lactat find provid basi studi structur activ relationship shmos blueprint improv infant formula
D008895;D008892
T168;T031
36,278,933
biomimet emitt inspir green fluoresc protein uniqu tripeptid structur green fluoresc protein gfp ser tyr gli motif generat matur chromophor situ defin emiss profil gfp describ ration design discoveri biomimet fluoresc emitt mbp mimick key structur ser tyr gli motif systemat tailor tripeptid famili four chromophor engin mbp exhibit bright fluoresc differ fluid solvent high enhanc quantum yield distinct previous hydrogen bond induc fluoresc quench gfp chromophor analogu emiss mbp slight decreas protic solvent heteronuclear multipl bond correl techniqu demonstr fundament mechan enhanc fluoresc emiss owe synergi format intramolecular hydrogen bond ring structur self restrict effect illustr via theoret calcul work put forward extraordinari approach toward high emiss biomimick fluorophor give new insight emiss mechan photophys gfp like chromophor
D032701;D006859
T090;T196
36,278,932
involv triplet state isomer retinaloid rhodopsin form famili photoreceptor protein util retin chromophor light energi convers upon light absorpt retin chromophor undergo photoisomer reaction involv non radiat relax conic intersect singlet excit state ground state work studi possibl involv triplet state photoisomer retinaloid use extend multist xms version caspt end truncat model three retinaloid consid proton schiff base deproton schiff base aldehyd form optim geometri reactant product conic intersect connect linear interpol intern coordin describ isomer energet posit low lie singlet triplet state well spin orbit coupl matrix element socm calcul along isomer profil socm valu peak vicin conic intersect retinaloid furthermor magnitud socm invari number doubl bond model socm proton schiff base neglig cm render involv triplet state improb howev largest socm valu cm found aldehyd form follow cm deproton schiff base
D012545;D012243
T123;T116;T109
36,278,929
design synthesi biolog evalu formyl pyrrolo b pyridin carboxamid new select potent revers coval fgfr inhibitor fgf fgfr signal pathway extens studi promis target treatment hepatocellular carcinoma hcc sever fgfr select inhibitor develop none receiv approv addit acquir resist caus fgfr gatekeep mutat emerg serious limit target therapi herein report novel seri formyl pyrrolo b pyridin deriv new revers coval inhibitor target wild type gatekeep mutant variant fgfr kinas repres compound z exhibit singl digit nanomolar activ wild type fgfr fgfr vlm mutant variant biochem baf cellular assay spare fgfr furthermor z show signific antiprolif activ hepb jhh huh hcc cell ic valu nm respect maldi tof ms x ray protein crystallographi studi consist z act revers coval inhibitor fgfr serv promis lead compound anticanc drug develop
D006528;D008113;D000970
T121;T191;T109
36,278,926
achir core metal chang isomorph enantiomer ag ag au ag cluster trigger circular polar phosphoresc understand chiral achir section chiral nanostructur contribut circular polar light emiss cple atom level fundament import report two pair atom precis enantiom homosilv rs agag heteromet rs auag cluster geometr chiral rs agag aris chiral ligand interfac consist posit moieti ag r ps circular dichroism rs agag activ cple silent complet metal chang ag au achir core section engend isomorph heteromet rs auag activ cple quantifi contribut achir chiral section first time unveil heteromet bond au ag linkag vari deloc orbit proport achir chiral section electron transit involv orbit thus activ cple base uniqu atom precis homochir metal cluster work provid new insight contribut achir chiral section origin chiropt respons chiral metal cluster pave way advanc develop cple nanoparticl
D049329;D053758
T073
36,278,925
copper catalyz three compon aminofluorin alken dien direct entri divers fluoroalkylamin rapid effici access structur divers fluoroalkylamin high demand wide presenc great import medicin chemistri drug develop direct aminofluorin alken offer ideal strategi one step entri fluorin amin readili avail start materi yet synthesi valuabl fluorin alkylamin remain unsolv challeng due inher incompat electrophil fluorid sourc electron rich alkylamin report unpreced catalyt three compon aminofluorin divers alken dien achiev innov copper catalyz electrophil amin strategi use benzoylhydroxylamin alkylamin precursor use et nhf also critic commerci avail inexpens fluorid sourc enabl effect fluorin also acid sourc format aminyl radic cation electrophil amin mechanist experi suggest involv aminyl radic speci carbon radic intermedi reaction condit method featur high regioselect good toler divers function group provid practic direct entri broad rang fluorin electron rich alkylamin synthet applic method also highlight use rapid entri fluorid amin contain pharmaceut natur product bioactiv compound
D000475;D003300
T123;T196;T121;T109
36,278,924
molecular imprint ratiometr fluoresc nanosensor molecular imprint ratiometr fluoresc mir fl nanosensor featur recognit select detect sensit applic univers visual accuraci devic portabl gain popular howev fluoresc intens nanostructur color rang practic applic sensor still face sever difficulti solv new strategi combin various technolog develop construct mir fl nanosensor expand applic perspect highlight current resarch challeng futur prospect involv construct applic mir fl nanosensor includ dual emiss tripl emiss mode postimprint mixingmodif strategi microdevic multitarget detect focus technolog synergi sensitivityreproduc improv applic diversityport etc propos
D045663;D054802
T063;T073
36,278,923
non destruct extract separ nano microplast environment sampl densiti gradient ultracentrifug nano microplast nmps particl diamet mm widespread emerg pollut caus divers impact organ due size shape chemic properti despit fast increas nmp research effect method separ identifi nmp type environment sampl still lack develop simpl effect approach non destruct extract separ various type nmps environment sampl densiti gradient ultracentrifug dgu first time dgu capabl separ various nmps complex matrix high select puriti applic gradual chang densiti densiti gradient medium chang concentr volum csclwater solut g cm mm various nmps particl size littl nm could extract separ soil sampl high recoveri confirm effect compat dgu correct identif type nmps separ artifici soil sampl raman spectroscopi simultan thermal analysi sta pyrolysi gas chromatographi mass spectrometri py gc ms dgu compat analyt process compar exist method much less sampl pretreat time h overal dgu effect cheap method usdsampl separ nmps environment sampl soil water henc facilit research nmps relat terrestri marin environ well human health
D000080545;D014874
T131;T122
36,278,920
radic c h sulfon aren applic bioactiv dna encod molecul photocatalyst free electron donor acceptor eda complex photochemistri deem expand potenti photodriven radic chemistri report cross coupl reaction thianthrenium salt function aren sodium sulfin via photopromot singl electron transfer set process eda complex seri biarylsulfon obtain high site select reactiv mild practic radic reaction could appli bioactiv dna encod molecul
D004247
T123;T114
36,278,919
thionat toward high contrast acq die probe reprogram aqueous segreg behavior enlighten sulfur substitut g quadruplex ligand small molecul base fluoresc chemosensor provid power tool analyt chemistri howev organ essenc often curs aggreg caus quench acq aqueous context albeit praxi disaggreg induc emiss die strategi potenti solut still await improv due uncontrol aggregationsegreg process address issu herein suppos sulfur substitut molecul could serv promis strategi achiev evolv acq die probe prove concept precursor g quadruplex g ligand cq modifi get thionat version ctq strike ctq exhibit arrang aqueous segreg behavior compar cq therefor enhanc fluoresc perform research meantim manifest ctq remain possess favor g select wherebi could function evolv probe accur vitro g relat assay specif classif assay distinguish virus variant
D005456;D054856
T130;T086
36,278,918
per play anticanc role oncogenesi progress breast cancer via regul mekerk signal pathway studi aim explor express period circadian regul per major member circadian clock gene famili biolog function breast cancer
D020935;D063646
T191;T044
36,278,912
fine tune carbon flux artifici promot bacillus subtili enabl high level biosynthesi allulos allulos attract rare sugar use low calori sweeten signific health benefit meet increas market demand necessari develop effici extens microbi ferment platform synthesi allulos appli comprehens systemat engin strategi bacillus subtili wb introduc allulos epimeras daeas combin deactiv frua levdefg gmue balanc metabol network effici product allulos result strain initi produc gl allulos yield g alluloseg fructos screen obtain suitabl dual promot combin perform fine tune spacer region h fed batch ferment optim engin b subtili produc allulos titer gl yield gg convers rate allulos product strain promis platform industri product rare sugar
D001412;D005632
T121;T007;T109
36,278,911
metal free synthes ketothioamid ketoamid deriv sulfoxonium ylide effici base addit metal free synthet method ketothioamid ketoamid deriv readili avail sulfoxonium ylide describ sulfoxonium ylide primari secondari amin afford ketothioamid presenc element sulfur wherea ketoamid produc tbhp present reaction proceed well room temperatur generat correspond molecul good excel yield reaction scale toler rang function group simpl oper procedur
D000588
T109
36,278,902
monitor electrochem reaction gold nanoelectrod array via fluoresc enabl electrochem imag high spatial resolut fluoresc imag high densiti gold nanoelectrod array achiev anchor fluoresc molecul limit diffus meanwhil ionic liquid electrolyt refract index match optic system could effect improv sensit fluoresc imag moreov spatial resolv imag electrochem reaction singl nanoelectrod modifi singl pt nanoparticl achiev
D006046;D061848
T060;T121;T196
36,278,897
supramolecular nitric oxid nanodeliveri system prevent tumor metastasi inhibit platelet activ aggreg tumor cell induc platelet aggreg tcipa known critic step hematogen tumor metastasi endogen nitric oxid play import role anticoagul might great potenti inhibit tcipa herein glutathion sensit supramolecular nanocarri prepar via host guest interact effect deliveri chemotherapeut agent gemcitabin gem could effect releas tumor cell inhibit platelet activ aggreg inhibit tcipa could effect attenu migrat invas tumor cell vitro furthermor vivo experi demonstr gem co deliv supramolecular nanocarri suppress growth primari tumor import although contain nanocarri inhibit growth primari tumor effect signific inhibit tumor metastasi base nano deliveri system provid new inspir multifunct applic cancer therapi also show great potenti clinic antimetastat applic
D009569;D010974
T121;T197;T043
36,278,895
translat regul zarl control time meiosi xenopus oocyt oocyt matur earli embryo develop occur vertebr near absenc transcript thus sexual reproduct vertebr critic depend time translat mrnas alreadi stockpil oocyt yet translat activ specif mrnas tempor coordin still incomplet understood elucid function zarl yet uncharacter member zar rna bind protein famili xenopus oocyt employ trim away demonstr loss zarl acceler hormon induc meiotic resumpt xenopus oocyt due prematur accumul phase promot kinas cmos show zarl constitu larg ribonucleoparticl contain translat repressor e central polyadenyl regul cpeb bind direct cmos mrna partial hormon induc degrad zarl liber e cpeb weaken translat repress mrnas encod cmos like addit phase promot factor thus studi provid fundament insight mechan ensur tempor regul translat key cell cycl regul oocyt matur essenti sexual reproduct
D008540;D009865
T025;T043
36,278,891
platinum base adjuv therapi effici tripl negat breast cancer meta analysi random control trial tripl negat breast cancer tnbc aggress breast cancer neoadjuv chemotherapi wide accept treat tnbc systemat review meta analysi aim evalu efficaci safeti surviv benefit platinum base adjuv therapi pbat treat tnbc keyword search medlin embas pubm cochran librari databas juli random control trial rcts compar pbat non pbat treat tnbc includ studi patholog complet remiss pcr complic compar odd ratio confid interv cis overal surviv os relaps free surviv rfs compar hazard ratio hr cis total rcts includ meta analysi among patient treat pbat non pbat patient treat pbat combin signific higher pcr rate compar patient treat non pbat versus ci p besid patient treat pbat signific better rfs hr ci p os hr p although occurr neutropenia nausea slight differ pbat group non pbat group complic accept two treatment group result demonstr tnbc patient treat pbat could achiev higher pcr rate better rfs benefit without higher complic rate highlight platinum base adjuv therapi provid higher pcr rate tnbcplatinum base adjuv therapi prolong rfs without prolongingth osneutropenia nausea rate differ group pbat non pbat
D064726;D009503
T047;T191
36,278,890
crispr base colorimetr nucleic acid test visual readout dna barcod food authent food authent critic issu associ economi religion food safeti herein report label free colorimetr nucleic acid assay detect dna barcod enabl determin food authent nake eye method term cri spr base c olorimetr dna barcod cricba assay util crisprcasa crispr cluster regular interspac short palindrom repeat cas crispr associ protein specif recogn polymeras chain reaction pcr product tran cleavag peroxidas mimick g quadruplex dnazym base principl presenc cytochrom oxidas subunit gene could direct observ nake eye via color chang tetramethylbenzidin sulfat tmb whole detect process includ pcr amplif tmb colorimetr analysi complet within min propos assay detect pufferfish concentr dilut ww raw pufferfish mixtur make one sensit method food authent robust assay verifi test four common speci pufferfish includ lagocephalus inermi lagocephalus spadiceus takifugu bimaculatus takifugu alboplumbeus assay advantag easi signal readout high sensit general applic thus could competit candid food authent
D003124;D021881
T116;T059;T126;T114
36,278,889
high perform blood plasma separ base janus membran techniqu rbc agglutin reaction separ plasma full various biomark critic clinic diagnosi howev point care plasma separ often reli microfluid filtrat membran usual limit puriti yield hemolysi extract speed hematocrit level protein recoveri develop high perform plasma membran separ techniqu base janus membran red blood cell rbc agglutin reaction rbc agglutin reaction form larger rbc aggreg separ plasma blood cell janus membran serv multipor microfilt block larg rbc aggreg allow plasma flow hydrophob side hydrophil side spontan result separ techniqu extract high purifi plasma whole blood ultra high plasma yield addit separ techniqu independ hematocrit level avoid hemolysi
D006461;D010949
T047;T046;T031
36,278,884
co catalyz dual cc h bond function imidazo pyrazin disulfid grignard reagent effici difunction cc imidazo pyrazin develop use disulfid grignard reagent cheap cobalt catalysi one pot two step three compon transform perform mild condit various grignard reagent aryl alkyl disulfid toler mechanist studi control experi demonstr reaction proceed via anion intermedi
D011719;D004220
T104;T109
36,278,880
polyelectrolyt surfact complex formul tool drug deliveri aqueous polyelectrolyt surfact complex pesc rich respect properti structur form design normal contain hydrophob micellar surfact aggreg complex long polyelectrolyt chain therebi combin format small hydrophob domain given surfact larg scale structur due presenc polyelectrolyt chain addit contain high polar region surfact head group contact polyelectrolyt form shell around micellar aggreg often also possess certain hydrophob charact accord abil solubil water insolubl compound differ sort particular versatil pesc solubil site differ polar hydrophob charact make flexibl adapt requir given drug molecul render attract potenti applic drug deliveri addit modif rheolog properti via self assembl network format import pesc applic follow discuss structur pesc properti focus solubil properti subsequ exampl describ pesc employ context drug solubil deliveri compris exampl individu aggreg cross link hydrogel one take advantag high solubil capac microemuls
D013501;D011663
T120;T123;T121;T109;T122
36,278,875
map adult human esophagus vivo vitro mani esophag diseas aris develop throughout life therefor well character vitro model detail method essenti studi human esophag develop homeostasi diseas creat atlas cell type observ normal adult human esophagus establish ancestr divers biobank vitro esophagus tissu interrog homeostasi injuri benchmark vitro model use adult human esophagus atlas creat singl cell rna sequenc refer atlas use fresh adult esophagus biopsi continu expand biobank patient deriv vitro cultur n line identifi valid sever transcript distinct cell class nativ human adult esophagus four popul belong epitheli layer includ basal epibas earli differenti termin differenti lumin cell benchmark vitro esophagus cultur vivo refer use singl cell rna sequenc show basal stem cell robust maintain vitro divers epitheli cell type cultur depend cell densiti also demonstr cultur grown organoid method employ model complet epitheli layer therebi enabl vitro model human adult esophagus
D009940;D004947
T023;T024
36,278,873
electrochem sensor made micro mesopor structur coni ngan noninvas detect glucos noninvas detect glucos ngd import global popul suffer diabet herein three dimension micro mesopor structur ie coni n nanosheet coat gan scaffold coni n gan propos detect saliva glucos gan scaffold provid larg open surfac nanosheet decor catalyt nanosheet increas surfac area prevent gan anod corros moreov found high temperatur ammoni coni lead dens atom hole n termin surfac coni n promot ionize coni higher catalyt activ first time dens atom hole observ coni knowledg design coni n gan sensor appli electrochem detect glucos low limit detect lod nm high sensit select stabil addit detect human saliva glucos realiz lod fold lower report reliabl lod integr sensor low consumpt saliva sampl demonstr ngd
D005947;D052078
T123;T121;T204;T109
36,278,872
recalibr vision action requir year sight restor congenit cataract abl perform adept goal direct action requir predict feed forward control includ map visual estim target locat motor command reach map perturb eg due muscl fatigu optic distort quick abl recalibr sensorimotor system updat map investig whether earli visual visuomotor experi essenti develop sensorimotor recalibr end assess young individu depriv pattern vision due dens congenit bilater cataract surgic treat sight restor year birth compar recalibr perform distort age match sight control sensorimotor recalibr perform impair right surgeri find explain still lower visual acuiti alon sinc blur vision control match degre lead compar behavior nevertheless recalibr abil cataract treat particip gradual improv time surgeri thus lack earli pattern vision affect visuomotor recalibr howev abil lost slowli develop sight restor highlight import sensorimotor experi gain late life
D002386
T033;T047;T190
36,278,870
nav essenti propriocept signal motor behavior voltag gate sodium channel nav nav well studi central nervous system convers contribut peripher sensori neuron function enigmat identifi new role nav mammalian propriocept rnascop analysi vitro patch clamp record genet identifi mous proprioceptor show ubiquit channel express signific contribut intrins excit notabl genet delet nav sensori neuron caus profound visibl motor coordin deficit condit knockout mice sex similar condit piezo knockout anim suggest channel major contributor sensori propriocept transmiss ex vivo muscl affer record condit knockout mice found loss nav lead inconsist unreli proprioceptor fire character action potenti failur static muscl stretch convers affer respons dynam vibrat unaffect suggest combin piezo nav isoform suffici elicit activ respons transient stimuli nav requir transmiss receptor potenti generat sustain muscl stretch impress record affer heterozyg condit knockout anim similar impair heterozyg condit knockout mice also exhibit motor behavior deficit thus nav haploinsuffici sensori neuron impair proprioceptor function motor behavior import human patient harbor nav loss function mutat often present motor delay ataxia therefor data suggest sensori neuron dysfunct contribut clinic manifest neurolog disord nav function compromis collect present first evid nav essenti mammalian propriocept signal behavior
D011984;D061566
T026;T123;T116
36,278,869
modular synthesi diaryl amino ester via bi v mediat aryl n displac kukhtin ramirez intermedi report concis modular approach diaryl amino ester readili avail keto ester mild one pot protocol proceed via keton umpolung situ format kukhtin ramirez intermedi preced sequenti electrophil aryl bi v n displac amin methodolog compat wide rang anilin primari amin includ deriv drug proteinogen amino acid bi v aryl agent keto ester substrat
D004952;D000596
T123;T121;T116;T109
36,278,865
quantum dot base micromotor nir light photocatalyt propuls nir ii fluoresc report first pbs quantum dot qd base micromotor nir light driven photocatalyt propuls nir ii fluoresc irradi nir light nm pbs qd dope cuprous oxid cu pbs micromotor display effici propuls varieti biocompat fuel malic acid glucos urea among cu pbs micromotor exhibit best propuls perform low concentr malic acid averag speed high ms enhanc nir photocatalyt activ cu pbs micromotor benefit dope nir pbs qds excit nir light exhibit high electron transport effici dope pbs qds effect increas absorpt effici micromotor nir region also inhibit recombin photogener electron hole pair interest due presenc nir pbs qds cu pbs micromotor demonstr promin stabl nir ii fluoresc emiss wavelength nm offer promis potenti visual posit vivo comparison photocatalyt micromotor simpl fabric strategi excel nir ii fluoresc togeth nir light depend propuls behavior current cu pbs micromotor thus pave way develop advanc smart robot intellig biomed applic
D045663
T073
36,278,862
mutat threonin synthas uncoupl prolifer transit domain root apic meristem experiment evid silico propos mechan continuum stem transit amplifi differenti cell state common theme multicellular organ plant root apic meristem ram transit amplifi cell organ two domain cell prolifer domain pd displac transit domain td suggest domain necessarili coupl show arabidopsi thaliana mto mutant threonin thr synthesi affect ram lack pd combin cell length profil analysi mathemat model molecular marker establish pd td uncoupl remark although ram mto repres sole td known factor ram mainten auxin signal express mutant mathemat model predict stem cell nich depend thr metabol disturb normal continuum cell state becom abort
D029681;D017360
T116;T002
36,278,852
iron iii catalyz synthesi indol xanthydrol hybrid oxid cycloisomerizationhydroxyl reaction effici one pot synthesi indol xanthydrol hybrid describ presenc catalyt combin fe fecl strategi involv seri reaction allyl oxid isomeris cyclis hydroxyl reaction tandem manner protocol offer sever advantag includ mild reaction condit oper simplic high select good yield easili access start materi synthet util protocol demonstr one pot synthesi high substitut xanthen contain bis indolylmethan deriv preliminari mechanist studi reveal reaction initi generat radic presenc catalyt iron iii salt
D007501;D014966
T123;T196;T121;T109
36,278,845
endometri injuri pregnanc follow sexual intercours intrauterin insemin intent endometri injuri propos techniqu improv probabl pregnanc women undergo assist reproduct technolog art vitro fertilis ivf endometri injuri often perform pipell biopsi common gynaecolog procedur establish safeti howev caus moder degre discomfortpain requir addit pelvic examin effect procedur outsid art women coupl attempt conceiv via sexual intercours intrauterin insemin iui remain unclear
D000022;D007247
T033;T047;T046
36,278,840
imag edit phospholipidom conspectusmembran multifunct supramolecular assembl encapsul cell organell within glycerophospholipid abund compon membran make major lipid bilay play structur function role organell differ phospholipid composit critic function result dynam interplay regul numer lipid metabol enzym lipid transport lipid structur local direct genet encod chemistri much offer world lipid biolog form precis tool visual lipid local abund manipul lipid composit general decod function lipid cellsin account provid overview recent effort space focus two overarch complementari goal imag edit phospholipidom imag front har power bioorthogon chemistri develop fluoresc report specif lipid pathway substanti effort center phospholipas pld signal generat humbl lipid phosphatid acid pa act variabl biosynthet intermedi signal agent though pld hydrolas generat pa abund phosphatidylcholin pc lipid exploit transphosphatidyl activ exogen clickabl alcohol follow bioorthogon tag generat fluoresc lipid report pld signal set method term impactimpact variant facilit mani biolog discoveri use rapid fluorogen tetrazin ligat reveal spatiotempor dynam diseas relev g protein coupl receptor signal interorganell lipid transport impact use diazirin photo cross linker enabl identif lipid protein interact relev alcohol relat diseas vari alcohol report allow organell select label vari bioorthogon detect reagent afford super resolut lipid imag via expans microscopi combin impact genom wide crispr screen reveal gene regul physiolog pld signalingpld enzym also act tool precis edit phospholipid content membran optogenet pld condit blue light stimul synthesi pa defin organell compart led discoveri role organell specif pool pa regul oncogen hippo signal direct enzym evolut pld enabl impact yield high activ superpld broad substrat toler abil edit membran phospholipid content synthes design phospholipid vitro final azobenzen contain pa analogu repres altern chemic strategi light mediat control pa signalingcollect strategi describ summar progress date tackl challeng assign precis function defin pool phospholipid cell also point new challeng direct futur studi includ extens imag membran edit tool class lipid envis continu applic bioorthogon chemistri optogenet direct evolut yield new tool discoveri interrog phospholipidom reveal new mechan regul phospholipid homeostasi role phospholipid cell signal
D010712;D010739
T126;T116;T109
36,278,837
synthesi reactiv sulfonylcyclooctatriazol strain eight member cyclic alkyn undergo rapid invers electron demand cycloaddit sulfonyl azid give correspond sulfonylcyclooctatriazol excel yield treatment sulfonyltriazol chiral rhodium ii carboxyl catalyst prompt transannular c h bond insert good yield excel ee h shift
D000480;D012238
T196;T109
36,278,834
hydrophob speci enabl acid base multi catalysi stereoselect access renew tran anethol tran anethol tran wide appli food daili necess pharmaceut typic avail ineffici natur oil extract complex organ transform miner acid nobl metal green sustain rout develop stereoselect produc tran ca select organ polymer phosphon hafnium catalyst pas hf cascad transfer hydrogen dehydr biomass base methoxypropiophenon mopp environment impact factor e factor porous structur enhanc hydrophob spheric catalyst pas hf ensur format access stabl lewi hf brnsted h acid activ site could use rapid convers biomass base mopp convers yield h tof h densiti function theori dft calcul elucid addit pas hf could remark facilit overal convers process decreas reaction energi barrier kj mol rate determin step good thermal stabil heterogen bifunct catalyst respons constant activ least five consecut cycl synergisticrelay catalysi lewi acid base brnsted acid speci could extend ten kind aldehyd keton acid base multi catalyt protocol consider potenti cascad biomass convers via heterogen catalysi without base addit
D000081248
T109
36,278,831
promot regul vivo asymmetr self assembl strategi synthes heterogen nanoparticl signal amplif signal amplif common use enhanc sensit biolog analysi present strategi involv vivo asymmetr self assembl combin promot strength regul synthes heterogen nanoparticl signal amplif two express vector construct genet insert respect signal bind molecul hepat b core antigen protein hbcag structur differenti express two recombin protein presenc strong promot weak promot tac spontan asymmetr self assembl vivo heterogen hbcag nanoparticl nps high ratio signal bear target bind molecul obtain nanoparticl contain larg number green fluoresc protein signal molecul small number b immunoglobulin bind domain protein g antibodi bind thus enabl sensit immunoassay proof concept improv sensit antibodi detect achiev use heterogen nanoparticl conjug secondari antibodi molecul
D006512;D053758
T129;T073
36,278,819
effect free immobil bacterium stenotrophomona acidaminiphila yb glyphos degrad perform indigen microbi communiti structur overus glyphos result serious environment contamin thus effect techniqu remov glyphos environ requir herein isol novel strain stenotrophomona acidaminiphila yb complet degrad glyphos major metabolit aminomethylphosphon acid ampa yb degrad glyphos broad concentr rang mg l degrad effici within h mg l yb degrad glyphos via ampa pathway cleav c n bond follow degrad ampa subsequ metabol yb demonstr strong competit substanti acceler degrad glyphos differ soil degrad glyphos mg kg within day steril nonsteril soil respect immobil cell yb effici free cell display excel biodegrad effici sediment water system taken togeth yb ideal degrad bioremedi glyphos contamin site
D012987;D064307
T001;T032;T028;T167
36,278,817
impact differ geometr restrict nonadiabat photoisomer biliverdin chromophor photoisomer mechan chromophor bacteri biliverdin bv phytochrom explor via nonadiabat dynam simul use fli trajectori surfac hop method semi empir ommrci level particular current studi focus influenc geometr constrain nonadiabat photoisomer dynam bv chromophor rather simplifi approach employ nonadiabat dynam captur featur geometr constrain add mechan restrict specif moieti bv chromophor simplifi method provid rather quick approach examin influenc geometr restrict photoisomer expect differ constrain bring distinct influenc photoisomer mechan bv chromophor give either strong minor modif involv reaction channel excit state lifetim constrain ad differ ring moieti observ contribut primari understand role spatial restrict caus biolog environ photoinduc dynam bv chromophor also provid use idea artifici regul photoisomer reaction channel phytochrom protein
D001664;D010834
T123;T116;T109
36,278,809
current status futur prospect nanoscal metal organ framework bioimag import earli stage diagnosi situ monitor lesion region transport bioactiv molecul pivot effect success treatment reduc side effect increas chanc surviv case serious diseas cancer strong depend develop contrast agent biomark togeth appropri use bioimag techniqu except high surfac area poros nanoscal metal organ framework nmof subject numer studi biomed domain drug carrier diagnost therapeut agent biosensor review provid summari recent advanc use mof nanoscal platform biomed imag via magnet reson mr imag comput tomographi ct singl photon emiss comput tomographi spect fluoresc fl imag positron emiss tomographi pet photoacoust pa imag phototherm pt imag modal initi describ principl specif imag techniqu section present recent report mof monomod multimod imag follow inform synthes mof modifi surfac ii util bioimag theranost applic
D000073396;D009369
T191;T109
36,278,807
fluoresc probe base acridin deriv applic dynam monitor cell polar variat polar viscos import microenviron paramet play essenti role cell metabol therefor acridin carboxaldehyd react cyano compound obtain polar sensit probe b viscos sensit probe c among increas solvent polar maximum emiss wavelength acridin dicyanoisophoron base probe red shift nm nm fluoresc quantum yield increas fluoresc intens enhanc fold acridin cyanofuranon base probe b also polar respons similar nevertheless solut viscos increas cp water cp water fluoresc intens acridin tricyanodihydrofuran base probe c nm enhanc time acridin cyanobenzothiazol base probe also viscos respons similar c addit probe b use hela cell imag experi due good photost result suggest probe could locat lipid droplet probe b c could stain lysosom moreov probe b could dynam monitor chang intracellular polar
D005456;D016764
T130;T082
36,278,800
phosphin base redox method direct conjug disulfid technolog cystein disulfid detect conjug pivot understand protein function develop disulfid deriv therapeut agent current disulfid modif requir reduct cleavag prior function pose challeng differenti disulfid free thiol describ herein redox assist disulfid direct conjug rddc new method enabl disulfid rebridg without cross react free thiol
D004220;D010720
T104
36,278,798
formal annul diamin prop ynyl sulfonium salt synthesi tetrahydroquinoxalin formal annul diamin prop ynyl sulfonium salt develop strategi enabl effici access tetrahydroquinoxalin excel yield
D012492;D003959
T104;T109
36,278,793
electrochem function graphen high sensit detect nitrofurazon graphen nanosheet gs prepar ultrason exfoli bulk graphit n methyl pyrrolidon assist sodium pyrophosph obtain gs suspens modifi glassi carbon electrod gsgce function differ voltag eg v min ph phosphat buffer electrochem function gsgce ie egsgc possess oxygen contain group higher defect level import activ respons area electron transfer abil interfac adsorpt capac egsgc enhanc remark possibl mechan perform enhanc discuss sens applic egsgc detect nitrofurazon nfz investig compar gsgce egsgc much activ nfz oxid great increas detect sensit result high sensit electrochem detect method develop nfz detect limit nm practic applic egsgc test fish meat sampl show good accuraci feasibl
D006108
T196;T109
36,278,791
choic refer orbit linear respons calcul solut phase k edg x ray absorpt spectra simplest respons theori method comput vertic excit spectra condens phase configur interact singl excit cis linear respons time depend densiti function theori tddft within tamm dancoff approxim applic x ray absorpt spectroscopi xas method like cis tddft codifi singl excit wave function prone catastroph error main edg post edg featur whose shape act crucial fingerprint structur analys liquid show error manifest primarili due lack orbit relax convent linear respons theori core ioniz n electron refer like electron affin tddft elimin error spectral profil even highest energi part post edg crucial find singl excit atop core ioniz refer suffici elucid liquid phase xas spectra semi quantit accuraci open door method like electron affin cistddft use effici altern higher order wave function approach
D004583
T081;T196
36,278,771
explor versatil pentafulven maleimid cycloaddit ligat strategi buffer ph effect ligat chemistri often requir perform stringent condit preserv integr function bio conjug includ specif biolog buffer explor versatil pentafulven maleimid ligat bio conjug studi stabil coupl partner diel alder cycloaddit dac buffer use common biolog assay protein chemistri bioconjug stabil dialkylpentafulven maleimid deriv panel buffer ph valu monitor via h nmr spectroscopi pentafulven display excel stabil hydrolysi maleimid observ sever case although extent hydrolysi correl ph almost buffer pentafulven maleimid dac proceed effici signific faster rate maleimid hydrolysi condit studi buffer composit ph appear signific effect kinet dac second order rate constant k rang c studi highlight versatil pentafulven maleimid ligat proceed wide rang condit relev bio conjug maleimid hydrolysi aqueous system may promot inhibit certain buffer
D061565
T067
36,278,530
polymicrobi infect immunocompromis host covid realm beyond immunosuppress chang suscept present infect infect one pathogen also alter host respons differ unrel pathogen interact seen across multipl infect domain bacteria virus fungi act synergist deleteri impact host phenomenon well describ bacteri fungal infect complic influenza particular interest context covid pandem modul immun system crucial part success solid organ hematopoiet stem cell transplant herein present three case polymicrobi infect transplant recipi case exampl highlight complex host pathogen interact result clinic syndrom
D060085;D000086382;D018380
T061;T047;T067
36,278,529
improv gait robot assist train children cerebr palsi head right direct cerebr palsi cp non progress congenit neurolog disord affect differ physic cognit function children addit standard rehabilit advanc robot gait devic novel tool becom progress common part treatment cp aim studi evalu effect lokomat train addit convent rehabilit motor function qualiti life children atax spastic cp ascp ten children ascp attend robot rehabilit outclin ircc centro neurolesi bonino pulejo april june enrol studi receiv twenti four robot rehabilit session twice week three month session last min also provid convent physic occup therapi innov train found signific chang children outcom ie gmfm p lt signific improv sit p lt walk p lt moreov qualiti life young patient evalu parent signific improv p lt use robot system could consid effect complementari treatment improv gait well qualiti life children cp
D002547;D065287
T061;T019;T047
36,278,528
sar cov infect covid clinic cours viral acut respiratori distress syndrom ard caus death sar cov infect symptomat patient often suffer high fever loss appetit respons deficit fluid protein intak mani patient admit emerg room therefor hypovolem hypoproteinem often suffer respiratori distress accompani ground glass opac ct scan lung ischem damag lung capillari respons microscop hallmark diffus alveolar damag dad character hyalin membran format fluid invas alveoli progress arrest blood flow pulmonari vessel consequ progress congest increas lung weight progress hypoxia progress sever ard sequestr blood lung worsen hypovolemia ischemia differ organ probabl respons recruit inflammatori cell ischem peripher tissu releas acut phase mediat persist elev serum level posit acut phase marker hypoalbuminemia autopsi studi perform most patient die icu sar cov infect progress acut respiratori distress syndrom ard death certif chart respiratori insuffici hypovolem heart failur mention main caus death
D000086382;D012128
T047;T067