PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,689,608 | tempor trend factor associ inclus patient report outcom heart failur random control trial systemat review background patient report outcom pros import measur treatment respons heart failur assess tempor trend factor associ inclus pros heart failur random control trial rcts method result search medlin embas cinahl studi publish januari juli journal impact factor assess tempor trend use jonckheer terpstra test conduct multivari logist regress explor trial characterist associ pro inclus assess qualiti pro report use consolid standard report trial consort pro extens rcts includ pros report ci increas report p odd pro inclus greater rcts publish recent year adjust odd ratio aor per year ci p multicent aor ci p medium size aor ci p coordin central south america aor ci p test health servic aor ci p devicesurg aor ci p exercis aor ci p intervent rcts report median interquartil interv possibl consort pro item conclus half heart failur rcts publish high impact factor journal includ pros increas inclus pros time trial larg test pharmaceut intervent coordin north america europ lower adjust odd report pros relat trial qualiti pro report modest | D006333;D000071066 | T047;T170;T046 |
34,689,603 | ischem stroke acut decompens heart failur kchf registri background heart failur hf known risk factor ischem stroke data regard ischem stroke hospit acut decompens hf adhf limit method result analyz data multicent registri kyoto congest heart failur kchf registri enrol consecut patient adhf japan mean age year men patient acut coronari syndrom ac patient investig incid predictor ischem stroke hospit adhf hospit patient develop ischem stroke median interv admiss onset ischem stroke interquartil rang day common under caus cardioembol men ci ac ci absenc prior hf hospit ci high b type natriuret peptid bnp n termin probnp nt probnp level median admiss ci independ associ ischem stroke patient without ac independ risk factor ischem stroke fulli consist main analysi higher quartil bnpnt probnp level signific associ higher incid ischem stroke p trend patient ischem stroke show higher hospit mortal longer length hospit stay poorer function status discharg conclus hospit adhf patient develop ischem stroke men ac absenc prior hf hospit high bnpnt probnp level admiss independ associ ischem stroke | D002545;D006333;D020521 | T047;T046 |
34,689,602 | omic technolog person combin therapi cardiovascular diseas challeng opportun primari purpos omic technolog understand intricaci genom proteom metabolom molecular mechan reveal complex trait human diseas signific use omic technolog applic medicin gear studi pathogenesi sever disord detect biomark earli onset diseas challeng still omic discov novel molecular mechan biomark review differ type omic technolog explic aim provid emerg applic cardiovascular precis medicin technolog signific impact optim medic treatment individu reach higher level precis medicin | D002318 | T047 |
34,689,601 | assess differ atherogen indic predictor metabol syndrom spanish adolesc background inconsist result due age ethnic geograph differ found predict capac atherogen indic previous studi aim studi assess predict valu atherogen indic met spanish adolesc popul method cross section studi perform adolesc random recruit school southeastern spain anthropometr biochem paramet evalu identifi presenc met follow atherogen indic calcul triglycerid glucos tyg index atherogen index plasma aip non hdl cholesterol triglycerid hdl cholesterol ratio tghdl c ldl cholesterol hdl cholesterol ratio ldl chdl c total cholesterol hdl cholesterol ratio tchdl c result area curv auc receiv oper characterist curv use discrimin purpos aip atherogen index strong associ met unadjust odd ratio boy girl high maintain adjust differ factor auc valu atherogen indic boy girl respect conclus among atherogen indic studi aip one strong associ met spanish adolesc auc valu obtain roc analys suggest atherogen indic abil predict met atherogen indic interest use predict indic met howev studi need explor depth predict capac | D024821 | T047 |
34,689,599 | microscop transcriptom analys dalbergoid legum peanut reveal diverg evolut lead nod factor depend epiderm crack entri termin bacteroid differenti root nodul symbiosi rns pillar behind sustain agricultur play pivot role environment nitrogen cycl genet molecular cell biolog knowledg rns come model legum exhibit root hair mode bacteri infect contrast dalbergoid legum exhibit crack entri rhizobia step toward understand import group legum combin microscop analysi tempor transcriptom obtain dynam view plant gene express arachi hypogaea peanut nodul develop generat comprehens transcriptom data map read hypogaea two diploid progenitor genom addit perform blast search identifi nodul induc yet annot peanut gene comparison peanut medicago truncatula lotus japonicus glycin max show upregul peanut ortholog among test known rns relat gene indic conserv mechan nodul develop among member papilionoid famili unlik model legum recruit class phytoglobin deriv symbiot hemoglobin symh peanut indic diversif oxygen scaveng mechan papilionoid famili final absenc cystein rich motif contain nodul specif cystein rich peptid ncr gene recruit defensin like ncrs suggest divers molecular mechan termin bacteroid differenti summari work describ genet conserv diversif legum rhizobia symbiosi papilionoid famili well among member dalbergoid legum formula see text copyright author open access articl distribut cc nc nd intern licens | D010367;D046913 | T002 |
34,689,598 | satellit cell express rage receptor advanc glycat end product import collater vessel format background growth remodel vascular network import compon prognosi patient peripher arteri diseas one protein previous implic play role process rage receptor advanc glycat end product studi sought determin cellular sourc rage ischem hind limb role rage signal cell type method result use hind limb ischemia model vascular growth studi found skelet muscl satellit cell novel major cellular sourc rage ischem tissu stain cellular sort although wild type satellit cell increas tumor necrosi factor monocyt chemoattract protein product respons ischemia vivo rage ligand vitro satellit cell rage knockout mice lack increas cytokin product vivo respons ischemia vitro stimuli rage ligand high mobil group box furthermor encapsul wild type satellit cell improv perfus hind limb ischemia surgeri perfus stain vessel quantif rage knockout satellit cell provid improv empti capsul conclus thus rage express signal satellit cell crucial respons stimuli angiogen arteriogen function | D017127;D007511 | T046;T109;T123 |
34,689,597 | potenti role marin speci deriv bioactiv agent manag sar cov infect covid caus sar cov outbreak result massiv global health crisi bioactiv molecul extract synthes use start materi obtain marin speci includ griffithsin plitidepsin fingolimod clinic trial evalu anti sar cov anti hiv efficaci current review highlight anti sar cov potenti marin deriv phytochem explor use silico vitro vivo model current literatur suggest molecul potenti bind various key drug target sar cov addit mani agent anti inflammatori immunomodulatori potenti thus could play role attenu covid complic overal agent may play role manag covid preclin clinic studi still requir establish role mitig current viral pandem | D009792 | T083 |
34,689,596 | femal sex angiotensin convert enzym ace insertiondelet polymorph amplifi effect adipos blood pressur pathophysiolog link adipos blood pressur complet understood evid suggest influenc sex genet determin aim identifi relationship adipos blood pressur independ robust set lifestyl metabol factor examin modul role sex angiotensin convert enzym ace insertiondelet id polymorph relationship insulin sensit cardiovascular diseas risc studi cohort normotens individu age year follow year character lifestyl metabol factor bodi composit ace genotyp bodi mass index bmi waist circumfer wc independ associ mean arteri pressur stronger relationship women men bmi r versus wc r versus p individu id ii ace genotyp sex p associ bmi wc mean arteri pressur independ age sex lifestyl metabol variabl standard regress coeffici bmi wc respect show signific interact ace genotyp women p cm larger wc baselin increas risk develop hypertens follow women odd ratio ci p ii genotyp carrier odd ratio ci p hypertens effect adipos pronounc women peopl carri ii variant ace genotyp marker salt sensit | D054643;D020641 | T086;T045 |
34,689,594 | systol blood pressur mortal communiti dwell older adult frailti effect modifi current evid insuffici support differ hypertens treatment target older adult evalu whether frailti modifi associ systol blood pressur sbp year caus mortal communiti dwell older adult longitudin data actif ulm studi activ function elder ulm germani collect associ sbp mortal analyz use cox proport hazard model adjust age sex educ smoke alcohol consumpt sleep disturb diastol blood pressur antihypertens medic evalu presenc effect modif frailti accord frailti index base accumul deficit among particip median age year women preval histori hypertens median sbp mm hg interquartil rang median diastol blood pressur mm hg interquartil rang median follow time year detect death identifi death frail particip frailti index effect modif frailti detect among non frail j shape associ found hazard ratio ci sbp mm hg hazard ratio ci sbp mm hg hazard ratio ci sbp mm hg frail older adult tendenc toward lower risk among sbp mm hg observ result suggest presenc effect modif frailti indic possibl protect effect elev sbp frail older adult respect caus mortal even adjust diastol blood pressur antihypertens treatment | D016330 | T100;T098 |
34,689,591 | long term exposur urban nois blood pressur level control among older adult figur see text | D004781;D009622 | T069;T037;T067 |
34,689,589 | strategi promot healthi lifestyl clinic set pillar ideal cardiovascular health scienc advisori american heart associ engag healthi lifestyl behavior suboptim vast major us popul meet current recommend healthi lifestyl defin consum healthi dietari pattern engag regular physic activ avoid exposur tobacco product habitu attain adequ amount sleep manag stress level health behavior well establish guidelin howev promot clinic set challeng critic overcom challeng greater promot heathi lifestyl practic clinic set effect motiv initi patient behavior chang model assess advis agre assist arrang develop provid framework clinic counsel requisit attent demand clinic set scienc advisori present strategi base model clinician health care profession use effici lifestyl relat behavior chang counsel patient level cardiovascular diseas risk everi visit addit discuss under role psycholog health well lifestyl relat behavior chang counsel clinician leverag health technolog provid brief patient center counsel greater attent healthi lifestyl behavior routin clinician visit contribut promot cardiovascular health | D015438;D006293;D000070497;D009042 | T055;T170;T041;T078;T058;T080 |
34,689,584 | impact manag strategi develop status potato cyst nematod popul switzerland overview present globodera rostochiensi g pallida success high special plant parasit nematod among regul quarantin pest global switzerland monitor annual survey sinc first detect swiss soil dataset creat review produc overview develop actual status potato cyst nematod pcns switzerland posit field repres sampl analyz distribut limit central west western switzerland suggest new introduct pcns spread initi introduc pcn popul occur way integr manag use switzerland appear effect howev increas avail potato varieti resist g rostochiensi limit avail varieti resist g pallida togeth biotic abiot factor promot chang domin either speci consequ extend monitor program interest swiss farmer avoid favor virul trait could present swiss globodera popul | D011198;D014431 | T204;T002;T168 |
34,689,582 | salt sensit hypertens renal injuri renal vasodysfunct associ dahl salt sensit rat abolish consom ssbn rat background abnorm renal hemodynam respons salt load thought contribut salt sensit ss hypertens howev base larg studi anesthet anim littl data avail conscious ss salt resist rat method result assess arteri blood pressur renal function renal blood flow administr nacl high salt nacl diet conscious chronic instrument week old dahl ss consom ss rat chromosom salt resist brown norway strain introgress genom ss strain ssbn three week high salt intak signific increas blood pressur exacerb renal injuri ss rat contrast increas blood pressur similar attenu brown norway ssbn rat strain complet protect renal injuri ssbn rat week high salt intak associ signific decreas renal vascular resist increas renal blood flow contrast renal vascular resist fail decreas renal blood flow remain unchang ss rat high salt intak final urinari sodium excret glomerular filtrat rate similar ss ssbn rat nacl high salt intak conclus data support concept renal vasodysfunct contribut blood pressur salt sensit dahl ss rat gene rat chromosom play major role modul renal hemodynam respons salt load salt induc hypertens | D006977 | T047 |
34,689,581 | center variabl medicar claim base public report transcathet aortic valv replac outcom measur background public report transcathet aortic valv replac tavr claim base outcom measur use identifi high low perform center whether claim base tavr outcom reliabl use center level comparison unknown studi sought evalu center variabl claim base tavr outcom use public report method result studi sampl includ medicar beneficiari undergo tavr januari octob base procedur code medicar inpati claim multivari hierarch logist regress use estim center specif adjust rate reliabl r day mortal discharg homeself care day stroke day readmiss reliabl defin ratio hospit variat sum within hospit variat median interquartil rang iqr center level adjust outcom rate day mortal discharg home day stroke day readmiss median reliabl highest discharg home measur r iqr follow day stroke r iqr day mortal r iqr day readmiss measur r iqr across outcom invers relationship center volum measur reliabl conclus claim base tavr outcom measur mortal discharg home stroke reliabl measur center level comparison readmiss measur unreli stakehold consid find evalu claim base measur compar center level tavr perform | D001024;D065467 | T047;T061 |
34,689,580 | shift demograph mental health co morbid among gender dysphor youth refer specialist gender dysphoria servic past research identifi shift demograph co occur mental health issu youth refer certain gender dysphoria servic present studi examin shift demograph age sex social transit status social advers bulli experi abus psycholog function mood anxieti suicid autism spectrum disord time referr children adolesc gender ident develop servic london year patient children adolesc sd rang assign femal birth littl chang sex ratio age observ two time point howev observ greater rate depress anxieti birth assign femal birth assign male recent cohort time report social advers bulli abus fall also interest proport young peopl partial fulli social transit prior contact servic increas overtim discuss potenti factor drive shift implic support recent cohort gender divers young peopl | D000067877;D000068116;D063106 | T048;T098 |
34,689,579 | union rate talar neck fractur substanti bone defect treat autograft studi evalu union rate talar neck fractur substanti bone defect treat acut autolog tibial bone graft primari osteosynthesi | D050723;D013628 | T023;T037 |
34,689,577 | understand deliveri patient center survivorship care plan exploratori interview studi complex cancer survivor understand key element survivorship care plan process patient center communic pcc health self efficaci critic deliv patient center survivorship care cancer survivor multipl chronic condit complex cancer survivor build upon team recent research effort examin survivorship care plan process patient center len exploratori studi leverag ongo quasi experiment trial elucid experi complex cancer survivor survivorship care plan post treatment manag | D000073116;D000073859 | T079;T101;T201 |
34,689,573 | distinct preval atherosclerot embol sourc cryptogen stroke cancer status background cerebrovascular diseas common comorbid patient cancer although activ cancer caus ischem stroke multipl patholog condit includ thromboembol attribut trousseau syndrom relationship stroke inact cancer poor known aim studi elucid differ under pathogenes cryptogen stroke activ inact patient cancer detail investig transesophag echocardiographi method result challeng esusc mechan embol stroke clarifi transesophag echocardiographi embol stroke undetermin sourcecryptogen stroke registri multicent registri includ data patient initi diagnos cryptogen stroke undergo transesophag echocardiographi patient divid activ cancer inact cancer noncanc group clinic featur compar total enrol patient age year men activ cancer histori inact cancer multinomi logist regress analysi infarct multipl vascular territori odd ratio ci crp c reactiv protein ci independ associ activ cancer wherea age ci contralater carotid stenosi index stroke lesion ci calcif aortic valv ci complic lesion aortic arch ci signific associ inact cancer conclus patient cancer rare cryptogen stroke although patient activ cancer multipl infarct patient inact cancer atherosclerot embol sourc potenti caus arteriogen stroke registr url https wwwuminacjpctr uniqu identifi umin | D000083262;D004617;D009369;D020521 | T033;T191;T047;T046 |
34,689,572 | chang demograph tempor trend waitlist posttranspl outcom heart transplant unit state analysi uno databas sought investig tempor trend patient characterist waitlist posttranspl outcom heart transplant unit state | D003710 | T082;T097;T170;T081;T078;T062;T090 |
34,689,571 | fgf fibroblast growth factor cardioren interact anim model implic fgf fibroblast growth factor direct contributor advers cardioren interact sodium avid diuret resist neurohormon activ conclus demonstr human therefor aim evalu whether fgf associ paramet cardioren dysfunct human heart failur independ confound factor | D012964 | T034;T196;T123 |
34,689,570 | special consider healthi lifestyl promot across life span clinic set scienc advisori american heart associ popul level engag healthi lifestyl behavior suboptim unit state moreov mark dispar exist healthi lifestyl behavior cardiovascular risk factor result social determin health addit specif challeng engag healthi lifestyl behavior relat age development stage major life circumst key compon healthi lifestyl consum healthi dietari pattern engag regular physic activ avoid use tobacco product habitu attain adequ sleep manag stress health behavior guidelin recommend howev promot clinic set challeng particular certain popul group challeng must overcom facilit greater promot healthi lifestyl practic clinic set model assess advis agre assist arrang develop provid framework clinic counsel consider demand clinic set scienc advisori summar specif consider lifestyl relat behavior chang counsel use model patient across life span life stage social determin health unmet social relat health need well overweight obes associ increas risk cardiovascular diseas potenti modifi risk lifestyl relat behavior chang addit specif consider lifestyl relat behavior chang counsel life stage lifestyl behavior signific affect cardiovascular diseas risk outlin greater attent healthi lifestyl behavior everi clinician visit contribut improv cardiovascular health | D002318;D015438;D006293;D000070497;D009042 | T047;T055;T170;T041;T078;T058;T080 |
34,689,567 | gruber frantz tumor rare pancreat neoplasm present case year old femal abdomin pain epigastrium radiat right flank month evolut physic examin epigastr mass palpat firm painless comput tomographi ct show cystic tumor bodi tail pancrea solid area defin border x cm displac structur endoscop ultrasound eus guid fine needl biopsi perform cytolog consist solid pseudopapillari tumor spt subsequ distal pancreatectomi tumor resect nodal dissect perform cytolog report discohes cell arrang around capillari small nuclei cleft ck negat catenin posit four year follow evid recurr | D010190 | T191 |
34,689,566 | express prognost signific dna damag respons pathway autophagi marker gastric cancer gastric cancer gc lead caus mortal morbid worldwid assess express pattern dna damag respons ddr relat marker includ atm chk p p rad brca autophagi relat protein includ p beclin gc specimen use immunohistochemistri stain gc tissu show lower level atm chk p p brca higher level rad compar adjac normal tissu autophagi relat protein p upregul wherea beclin downregul human gc group addit differ status ddr pathway autophagi character protein express associ overal surviv result indic impair dna damag autophagi may implic gastric cancer progress clinic prognosi | D013274 | T191 |
34,689,565 | develop valid multivari predict model egfr gene mutat status patient lung adenocarcinoma detect epiderm growth factor receptor egfr one real dilemma owe non suffici tissu test egfr mutat lung adenocarcinoma model predict egfr mutat would help clinic decis patient retrospect cohort patient diagnos lung adenocarcinoma investig decemb decemb renji hospit shanghai china patient test egfr mutat amplif refractori mutat system n next generat sequenc n patient lung adenocarcinoma met inclus criteria nomogram model develop base patient valid patient variabl associ egfr mutat age sex smoke histori lepid predomin subtyp solid predomin subtyp mucin adenocarcinoma ki express lobul solid textur radiolog pleural retract nomogram base model perform well develop group c index ci valid group c index ci probabl cut point diagnost effici patient ngs liquid biopsi decis curv analysi confirm clinic use nomogram show predict egfr mutat probabl appli nomogram would better patient none patient use nomogram high probabl group nomogram model may suggest high possibl egfr mutat tissu limit ngs base ctdna liquid biopsi could implement effect | D000077192;D008175 | T191 |
34,689,564 | metabolom signatur figo stage ii endometri cancer endometri cancer ec malign tumor femal reproduct tract due rapid growth invas ec current gynecolog neoplasm rise incid mortal rate great signific explor metabolom signatur stage ii ec diagnosi treatment mass spectrometri base untarget metabolom approach use explor preoper serum metabolit normal stage ii ec patient metabolit map ingenu pathway analysi ipa databas determin potenti biomark metabol pathway differ ec patient healthi control top analysi readi molecul upregul glucos thiamin downregul cholesterol arachidon acid palmit acid oleic acid stearic acid linol acid may relat metabolit potenti biomark essenti function regul vital metabol pathway associ stage ii ec addit pathway analysi reveal five signific relat pathway accord metabolit differenti final diseas function predict initi pathway analysi suggest small molecul biochemistri lipid metabol organism injuri abnorm associ ec case metabolit differenti express stage ii ec addit six signific metabolit relat stage stage ii ec case ingenu pathway analysi reveal potenti biomark metabol pathway revolv ec paper candid endogen biomark defin basi diseas diagnosi individu treatment monitor reveal mechan ec occurr develop | D014408;D016889 | T191;T123 |
34,689,561 | lenthionin key flavor substanc lentinula edod regul cystein drought stress due uniqu flavor profil lentinula edod becom one popular edibl mushroom world regulatori mechan flavor substanc reveal studi mechan regul anabol metabol import flavor substanc lenthionin lt effect cystein cys synthes cystathionin lyas cse gene particip regul lt metabol drought stress analyz result show drought stress promot accumul lt key gene gtt lecsl activ furthermor drought stress promot accumul intracellular cys activ key gene cys synthesi cse inhibit cse enzym activ inhibitor silenc cse gene drought stress signific reduc intracellular content cys lt inhibit lt synthesi disappear exogen addit cys result indic lt synthesi l edod drought stress depend cys summari mechan regul flavor substanc edibl mushroom environ reveal first time | D020942 | T004 |
34,689,560 | hypoxia respons polyprodrug nanocarri near infrar light boost photodynam chemotherapi hypoxia environ insid tumor tight associ tumor growth metastasi drug resist howev heterogon distribut hypox area limit efficaci hypoxia activat drug deliveri system herein report hypoxia activ block copolym polyprodrug compos poli ethylen glycol peg copolymer segment ortho nitrobenzyl link camptothecin cpt methacryl piperidin yl ethyl methacryl pema monom self assembl aqueous solut indocyanin green icg photosensit encapsul formul icg load micellar nanoparticl icg cptnb near infrar nir light boost photodynam therapi pdt tumor hypoxia aggrav respons drug activ intraven inject prolong blood circul nanoparticl accumul tumor effici tumor acid trigger charg transit pema unit remark promot cellular intern nanoparticl upon exposur nir laser irradi icg insid nanoparticl produc reactiv oxygen speci ros along local hypothermia simultan oxygen consumpt ros product aggrav intratumor hypoxia amplifi hypoxia respons self immol cpt releas nanoparticl combin photodynam chemotherapi use hypoxia respons polyprodrug nanoparticl icg cptnb overcom limit singl therapi hypoxia activ prodrug pdt remark improv effici tumor growth suppress | D010778 | T061 |
34,689,559 | cardiopulmonari mortal fine particul air pollut speci sourc nation us cohort purpos studi estim cardiopulmonari mortal associ long term exposur pm speci sourc ie compon within us nation health interview survey cohort exposur estim chemic transport model six speci ie element carbon ec primari organ aerosol poa secondari organ aerosol soa sulfat ammonium nh nitrat five sourc pm ie vehicl electr generat unit egu non egu industri sourc biogen sourc bio sourc singl pollut model found posit signific p mortal associ compon except poa adjust remain pm total pm minus compon found signific mortal associ ec hazard ratio hr ci soa hr ci vehicl sourc hr ci hrs ec soa vehicl sourc signific larger comparison remain pm per unit gm find suggest cardiopulmonari mortal associ vari speci sourc evid ec soa vehicl sourc import contributor pm mortal relationship valid find could facilit target pollut regul effici reduc air pollut mortal | D000393;D000397 | T131;T069;T080 |
34,689,558 | ligand enabl copper catalyz electrophil amin asymmetr synthesi amino acid catalyt asymmetr nitren transfer emerg reliabl method synthesi nitrogen contain chiral compound herein report copper catalyz intramolecular asymmetr electrophil amin aromat ring reactiv intermedi copper alkyl nitren generat isoxazolidin one copper catalysi promot three class asymmetr transform name asymmetr desymmetr parallel kinet resolut kinet resolut expand repertoir alkyl nitren transfer provid various cyclic linear amino acid enantioenrich form | D003300 | T121;T196;T123 |
34,689,555 | breathabl straintemperatur sensor base fibrous network ionogel capabl monitor human motion respir proxim wearabl strain temperatur sensor desir human machin interfac health monitor human motion monitor herein fibrous mat align nanofib ionic liquid il thermoplast polyurethan tpu ionogel fabric via electrospin techniqu result fibrous mat cut rectangl specimen electrod load along direct perpendicular nanofib orient design high perform multimod sensor base ionic conduct mechan strain sensor obtain sensor exhibit wide strain work rang fast respons recoveri ms low detect limit good reproduc revers deform ionic conduct pathway sensor moreov sensor also exhibit excel temperatur sens behavior includ monoton thermal respons high sensit c high accuraci c fast respons time remark repeat attribut negat temperatur coeffici behavior iltpu fibrous mat interest iltpu fibrous sensor possess good breathabl desir wearabl electron excel sens capabl strain temperatur sensor monitor tini larg human motion also detect respir proxim exhibit enorm potenti wearabl electron | D008991;D012119;D013696;D000076251 | T058;T039;T073;T081 |
34,689,552 | disentangl effect physicochem genet microbi properti phase driven resistom dynam multipl manur compost process compost alter manur deriv antibiot resist gene arg certain extent larg depend upon compost phase manur type microbi phylogeni physicochem properti howev littl known determin influenc fate dynam arg well mechan under ecolog process arg compost investig tempor pattern arg correl seri physicochem genet microbi properti pilot scale compost chicken maggot bovin swine manur detect arg co occur across four compost process account sum resistom abund support arg co occurr varianc partit analys demonstr manur type explain less resistom variat compost phase phase driven resistom dynam arg show diverg variat abund certain beta lactam multidrug arg consist enrich across multipl manur compost process correl analys led conclus diverg arg variat compost attribut unequ effect physicochem properti mobil element success indigen microbiota wherea antibiot residu effect margin ultim studi determin relat import various key determin phase driven diverg arg multipl manur compost process demonstr clear need evalu risk pose enrich arg toward receiv environ | D000076282 | T167;T068 |
34,689,550 | linear epitop play import role immunoglobulin g igg immunoglobulin e ige bind capac sci p sarcoplasm calcium bind protein stabl allergen scylla paramamosain name sci p explor import linear epitop immunoglobulin g igg immunoglobulin e ige bind capac sci p chemic denatur use destroy structur sci p reduc dithiothreitol subsequ alkyl iodoacetamid iaa furthermor structur analysi indic iaa sci p unstructur protein inhibit enzym link immunosorb assay show iaa sci p could inhibit bind sci p sensit serum inhibit rate reach moreov linear mimotop sci p predict silico three linear epitop verifi serolog test name l sci p aa l sci p aa l sci p aa overal data provid understand relationship structur allergen sci p identifi linear epitop use diagnosi food process shellfish allergi | D007074;D000067208 | T129;T047;T121;T116 |
34,689,548 | activ platelet home nanoplatform target magnet reson imag aneurysm relat thrombus rabbit thrombosi close relat instabl intracrani aneurysm ia whose ruptur associ high morbid mortal difficult detect ia relat thrombus tradit magnet reson imag mri even contrast enhanc mri clear distinguish thrombus surround tissu herein nanoplatform mfe zndpa nanoparticl nps consist zn co fe zn mn fe nps imag zn ii bis dipicolylamin zndpa thrombus target construct target experiment aneurysm relat thrombus rabbit via mri vitro experi includ platelet safeti evalu primarili prove mfe zndpa nps high mri transvers relax time good biocompat mfe zndpa nps could target thrombus via special interact zndpa phosphatidylserin activ platelet thrombus mri fe quantif assay moreov mfe zndpa nps inject ear vein common carotid arteri aneurysm model rabbit mri show mfe zndpa nps could accumul aneurysm relat thrombus min inject decreas next min meanwhil mfe zndpa nps could decreas mri signal aneurysm relat thrombus enhanc outlin aneurysm studi demonstr nanoplatform enhanc detect aneurysm relat thrombus well aneurysm assist treatment ia | D008279 | T170;T059;T060 |
34,689,547 | spatiotempor control dna nanoclamp singl molecul imag receptor protein oligomer cell membran surfac receptor protein play import role cellular biolog process numer method detect receptor yet develop artifici control specif detect treatment strategi remain challeng herein develop strategi base upconvers nanoparticl ucnp load dna probe enabl two color ratiometr imag excit nm laser light respons control signal open strategi avoid wast probe transport improv sensit therebi number receptor individu du cell membran count singl molecul detect due differ express specif receptor protein number singl fluoresc dot count use basi distinguish du cell work high control increas sensit provid platform cancer diagnosi treatment | D001686;D053758 | T070;T038;T073 |
34,689,544 | high sensit detect mir target activ catalyt hairpin assembl x shape dna nanostructur microrna mirna found extrem low concentr cell high sensit quantit great challeng herein simpl dual amplif strategi involv target activ catalyt hairpin assembl cha coupl multipl fluorophor concentr one x shape dna report strategi four hairpin probe h h h h modifi fam bhq sticki end circul hairpin probe h use activ cha circuit bind complementari sequenc target mir power dual amplif cascad frster reson energi transfer fret base nonenzymat nucleic acid circuit trigger h activ format x shape dna nanostructur free h next cha reaction cycl cha circuit increas fluoresc due wide distanc fam bhq form x shape dna nanostructur result signal amplif high sensit detect mir limit detect lod nm time lower obtain singl amplif strategi without multipl fluorophor one x shape dna cha circuit furthermor cascad reaction complet min effect avoid target degrad new enzym free signal amplif strategi hold promis potenti sensit detect differ dna rna sequenc simpli adapt fragment h sequenc complementari target | D015374;D021881;D035683;D049329 | T116;T073;T123;T114;T075;T059;T126 |
34,689,543 | superelast antifreez antidri conduct organohydrogel wearabl strain sensor sensor base conduct hydrogel receiv extens attent various field artifici intellig electron skin health monitor howev poor resili fatigu resist ice water loss tradit hydrogel great limit applic herein ionic conduct organohydrogel pac zn prepar first time copolymer cardanol acryl acid water butanediol binari solvent system small amount cardanol cardanol total monom could signific improv tensil strength time tough time paa also improv extens due presenc butanediol pac zn show outstand toler freez c dri moistur retent day storag c oven compar ethylen glycol glycerol antifreez agent use organohydrogel addit butanediol endow organohydrogel similar frost resist also better mechan perform besid pac zn exhibit fast resili almost hysteresi loop excel antifatigu abil import pac zn organohydrogel base sensor could detect human motion real time wrist elbow finger knee joint reveal fast respons good sensit stabl electromechan repeat conclus multifunct pac zn organohydrogel expect becom potenti promis candid field strain sensor broad rang environment temperatur | D001185;D000076251 | T066;T073;T090 |
34,689,540 | surgic treatment anterolater malleolar pain combin subfibular ossicl ankl arthroscopi evalu clinic outcom ankl arthroscop resect subfibula ossicl combin modifi brostrm techniqu pain extern malleolus caus subfibular ossicl patient april januari treat tianjin first central hospit patient includ male femal age year symptom last mean month month oper month follow visual analog scale vas pain score american orthoped foot ankl societi aofa score karlsson peterson kp score use assess clinic outcom vas pain score reduc aofa score increas kp score improv oper respect three assess score improv signific p case present postop complic non union incis skin necrosi infect etc method ideal cure pain extern malleolus caus subfibular ossicl advantag less trauma quick recoveri | D001182;D007593 | T061;T033;T060 |
34,689,539 | observ curat effect fibula transvers transport techniqu treatment diabet foot ulcer investig clinic effect fibula transvers transport techniqu treatment diabet foot ulcer nine patient male femal diabet foot ulcer treat fibula transvers transport techniqu septemb septemb mean age year rang year term wagner classif case grade case grade case grade case involv ischem ulcer ischem nerv ulcer transcutan oxygen pressur tcpo dorsal foot affect limb measur ulcer heal tcpo chang record follow patient follow month month found patient foot ulcer cure within month month patient obtain limb salvag besid serious complic occur skin necrosi needl tract infect oper tcpo affect foot mmhg mmhg kpa mmhg three month oper p techniqu fibula transvers transport effect improv microcircul function diabet foot promot heal ulcer complic | D003920;D017719 | T047 |
34,689,538 | analysi characterist collater circul pathway dizzi patient caus sever bilater vertebr arteri stenosisocclus clinic data patient male femal age year treat depart neurolog sixth medic center pla general hospit octob octob diagnos sever bilater vertebr arteri stenosisocclus digit subtract angiographi dsa retrospect collect characterist compensatori pathway collater circul determin result show intracrani extracrani compensatori pathway posterior communic arteri major type case intracrani one deep carotid arteri major type case extracrani one establish compensatori pathway close relat lesion site dsa assess patient sever bilater vertebr arteri stenosisocclus help clinician make judgement prognosi patient choos individu treatment plan | D016893;D014715 | T047;T020 |
34,689,537 | effect ketamin combin sufentanil patient control intraven analgesia earli recoveri elder patient undergo laparoscop radic resect rectal cancer object observ efficaci safeti ketamin combin sufentanil patient control intraven analgesia pcia elder patient undergo laparoscop radic resect rectal cancer explor impact patient earli recoveri method one hundr ten patient undergo laparoscop radic resect rectal cancer affili cancer hospit zhengzhou univers decemb march divid two group n use random number tabl group receiv pcia continu infus ketamin combin sufentanil group c receiv pcia continu infus sufentanil pcia initi end surgeri formul follow group ketamin mgkg sufentanil gkg ketorolac tromethamin mgkg tropisetron mg ml normal salin group c sufentanil gkg ketorolac tromethamin mgkg tropisetron mg ml normal salin postop visual analogu scale vas ramsay sedat scale record h surgeri incid remedi analgesia effect compress number pci h oper time first ambul time first anal exhaust time resum oral feed record occurr advers effect compar two group result total patient exclud studi includ case convers laparotomi case drop studi case oper time hour final case group case group c complet studi signific differ vas score ramsay sedat sore time point two group p likewis also signific differ number remedi analgesia effect compress pcia h oper two group p total dosag sufentanil consumpt group g lower group c g within h pcia statist signific differ p time first ambul group shorter group c differ statist signific p likewis time first anal exhaust group shorter group c statist signific differ p addit time resum oral feed group shorter group c statist signific differ p incid nausea vomit pruritus group lower group c respect statist signific differ p case psychiatr symptom found group conclus use postop intraven analgesia elder patient undergo laparoscop radic resect rectal cancer ketamin combin sufentanil provid satisfactori analges effect decreas total consumpt sufentanil incid advers effect thus facilit patient earli recoveri | D007649;D010535;D062645;D012004 | T191;T121;T109;T061;T060 |
34,689,536 | efficaci endoven microwav ablat treat primari varicos vein lower extrem object explor efficaci endoven microwav ablat treat primari varicos vein lower extrem method total patient primari varicos vein lower extrem first affili hospit sun yat sen univers januari novemb includ divid microwav ablat group n high ligat microwav ablat group n accord surgic approach subgroup includ subgroup diamet rate activ skin ulcer two group respect differ statist signific p local skin ecchymosi two group recov within month oper local skin numb group recov within maximum year follow activ skin ulcer group recov within maximum year follow conclus endoven microwav ablat safe effect especi combin high ligat great saphen vein good follow result achiev great saphen vein diamet smaller mm howev diamet greater mm surgic success rate endoven microwav ablat decreas | D053685;D014648 | T047;T074;T061 |
34,689,535 | mrna level n methyl aspart acid receptor nr subunit patient major depress disord relationship clinic featur object investig characterist glutamaterg neurotransmitt neurotransmiss dysfunct patient major depress disord mdd relationship clinic characterist method fifti two patient mdd healthi control select hamilton depress scale hamd hamilton anxieti scale hama use evalu symptom depress anxieti serum glutam level measur enzym link immunosorb assay elisa revers transcript polymeras chain reaction rt pcr use detect mrna level nr subunit nmda receptor result signific differ gender age mdd group healthi control group compar control group level serum glutam mgl vs mgl p mrna level nr vs p mdd group signific higher mdd group serum glutam level posit correl depress core symptom score r p mrna level nr subunit posit correl total cours diseas r p conclus mdd patient may disord glutamaterg neurotransmitt abnorm express nr subunit | D003865 | T048 |
34,689,534 | rest state function magnet reson imag analysi modifi electroconvuls therapi treatment major depress disord object explor effect modifi electroconvuls therapi mect rest state function connect rsfc patient major depress disord mdd method patient mdd anhui mental health center octob may includ use bilater nucleus accumben nacc seed point chang rsfc investig mect rest state function magnet imag fmri antidepress effect measur item hamilton depress rate scale hdrs correl analysi perform chang hrsd score chang function connect result total mdd patient male femal age year receiv mect includ studi mect patient show increas rsfc right nacc rnacc superior frontal gyrus p right supramargin gyrus p right angular gyrus rag p right inferior pariet lobul p left superior frontal gyrus lsfg p left middl tempor gyrus p left angular gyrus lag p respect rsfc chang rnacc lsfg r p rnacc rag r p rnacc lag r p negat correl chang hrsd score conclus mect may allevi major depress regul function connect rnacc bilater angular gyrus left superior frontal gyrus | D003865;D004565 | T048;T061 |
34,689,533 | associ coronari perivascular fat attenu index paramet plaqu fraction flow reserv object explor associ coronari perivascular fat attenu index fai paramet plaqu fraction flow reserv ffr method total patient plaqu male femal age year stabl coronari arteri diseas retrospect collect jingl hospit shanghai sixth peopl hospit patient underw coronari ct angiographi invas ffr examin quantit qualit paramet plaqu vessel length volum plaqu characterist plaqu high risk plaqu fai around plaqu measur patient divid posit fai group n negat fai group n accord standard whether threshold fai hu quantit index includ age length volum plaqu minim lumen area mla fai well qualit index includ characterist plaqu number characterist high risk plaqu number patient plaqu posit ffr compar two group logist regress analysi perform analyz correl among myocardi ischemia age length plaqu minim lumen area mla fai roc curv use evalu perform paramet result compar negat fai group posit fai group lower mla mm vs mm p proport patient vessel ffr posit fai group signific higher negat fai group vs p vs p fai high risk plaqu non high risk plaqu signific differ vs p fai predict myocardi ischemia auc p signific improv predict effici complex model vs p conclus lower mla higher incid myocardi ischemia associ patient higher fai addit fai certain predict effici provid increment valu determin myocardi ischemia | D023921;D053805 | T047;T201 |
34,689,532 | effect measur site coronari comput tomographi angiographi deriv instantan wave free ratio diagnosi coronari stenosi ischemia object explor influenc measur site diagnost perform coronari comput tomographi angiographi ccta deriv instantan wave free ratio ifr ct coronari stenosi ischemia method total patient includ male femal age year underw coronari comput tomographi angiographi ccta invas fraction flow reserv ffr depart radiolog eastern theater command general hospit februari may retrospect collect base ccta imag ifr ct valu differ locat stenosi proxim downstream stenosi cm downstream stenosi cm downstream stenosi cm downstream stenosi calcul fluid mechan simul invas ffr refer standard receiv oper characterist roc use analyz evalu diagnost perform ifr ct differ site bland altman spearman correl coeffici use analyz consist ifr ct invas ffr intraclass correl coeffici icc spearman correl coeffici use test repeat ifr ct result ifr ct valu proxim downstream stenosi approxim cm downstream stenosi superior measur site diagnosi coronari ischem specif stenosi threshold area curv sensit specif accuraci ifr ct stenosi ci ci ci ci respect bland altman analysi show mean differ ifr ct ffr proxim downstream stenosi loa spearman correl coeffici p proxim downstream stenosi intraobserv icc ifr ct ci correl coeffici p interobserv icc ci correl coeffici p demonstr good repeat ifr ct ffr conclus invas ffr valu refer standard ifr ct high diagnost perform detect myocardi ischemia best measur site proxim downstream stenosi | D023921;D053805;D017202 | T047;T201 |
34,689,531 | deep learn reconstruct algorithm coronari ct angiographi assess obstruct coronari arteri diseas caus calcifi lesion clinic applic valu object investig imag qualiti coronari ct angiographi ccta subject deep learn base reconstruct algorithm dlr method diagnost perform stenosi caus coronari calcifi lesion method enrol consecut patient known suspect coronari arteri diseas cad underw ccta subsequ invas coronari angiographi ica within month depart radiolog peke union medic colleg hospit februari februari among male femal age rang year ccta imag reconstruct dlr hybrid iter reconstruct hir imag nois signal nois ratio snr contrast nois ratio cnr calcul aorta root left main arteri proxim left anterior descend left circumflex right coronari arteri ccta imag use evalu object imag qualiti iq subject iq score grade use likert four point scale excel poor diagnost perform obstruct coronari arteri diseas caus calcifi lesion ccta subject dlr hir method evalu use ica refer standard result total lesion patient includ analysi imag nois dlr imag signific lower hir imag defin standard deviat attenu valu aortic root vs p cnr snr dlr imag aortic root higher cnr vs p snr vs p subject score dlr better hir imag vs p sensit specif accuraci dlr hir imag diagnos obstruct coronari arteri diseas caus calcifi lesion respect number fals posit case dlr imag decreas compar hir conclus artifici intellig base dlr signific reduc imag nois improv imag qualiti ccta dlr help improv diagnost perform ccta assess obstruct coronari arteri diseas caus calcifi lesion may good clinic applic valu | D003324;D000077321 | T047;T066 |
34,689,530 | quantit myocardi perfus paramet subject without coronari arteri lesion base comput tomographi dynam myocardi perfus imag object determin rang quantit myocardi perfus paramet mbf mbv subject without coronari arteri lesion dynam comput tomographi myocardi perfus imag ctp method subject occasion chest tight famili histori coronari arteri diseas come fuwai hospit underw coronari comput tomographi angiographi ccta prospect enrol total subject mean age year rang year male femal enrol coronari lesion confirm subject use ccta volunt stress rest dynam ctp examin mbf mbv valu calcul myocardi segment use segment model global rang mbf mbv analyz gender variabl region variabl compar result mean global mbf mbv rest stress ml g min ml g min ml g ml g respect absolut resolut reserv mbf mbv ml g min ml g highest right coronari arteri territori without signific differ stress mbf absolut reserv mbf femal higher male ml g min ml g min ml g min ml g min p conclus mean global mbf mbv rest stress ml g min ml g min ml g ml g mbf stress perfus mbf absolut reserv femal higher male | D003324;D055414 | T047;T060 |
34,689,529 | clinic signific non tradit lipid paramet concern atherosclerot cardiovascular diseas ascvd remain lead caus human death world dyslipidemia central mechan preval develop ascvd regard remedi risk factor cardiovascular diseas well known tradit lipid paramet low densiti lipoprotein cholesterol ldl c primari target lipid interf ascvd howev random control trial real world studi suggest residu risk persist spite well control ldl c level accord current guidelin henc recent year seri studi indic mani novel lipid indic close correl residu risk ascvd articl aim summar research status non tradit lipid paramet cardiovascular field | D050197;D002318;D050171;D019161 | T047;T121;T109;T046 |
34,689,528 | promot activ clinic applic advanc cardiovascular ct imag recent year cardiovascular imag becom import tool evalu cardiovascular diseas provid anatom function inform multidimension way expect posit impact diagnosi treatment cardiovascular diseas editori briefli describ current status advanc cardiovascular ct imag cardiovascular diseas diagnosi treatment decis make prognost evalu includ ct deriv flow fraction reserv ct perfus pericoronari adipos tissu applic artifici intellig order promot clinic transform technolog | D003324;D053805;D055414 | T047;T060;T201 |
34,689,527 | recent advanc diagnosi treatment mucormycosi | D009091 | T047 |
34,689,526 | role mechan interstiti cell cajal pathogenesi achalasia cajalinterstiti cell cajalicc icc icc | D004931;D056885 | T025;T047 |
34,689,525 | anti tumor mechan anti program cell death program cell death ligand monoclon antibodi pd pd lpd pd lpd pd lpd pd l | D000911;D009369 | T129;T191;T116 |
34,689,524 | recommend manag malign pleural mesothelioma mpmmpmmpmmpm | D008175;D000086002;D010997 | T191 |
34,689,523 | granulomatosi polyangi complic aortic intermur hematoma case report canca gd mgd g | D014890 | T047 |
34,689,522 | case report osullivan mcleod syndrom osullivan mcleodosullivan mcleod | D054546 | T047 |
34,689,521 | chang platelet relat paramet obes patient sleev gastrectomi compar chang platelet relat paramet obes patient sleev gastrectomi sg retrospect analyz clinic data obes patient underw sg peke union medic colleg hospit decemb septemb result show compar surgeri platelet count plt decreas signific week follow p platelet distribut width pdw mean platelet volum mpv larg platelet ratio p lcr increas signific period follow oper p howev level pdw mpv p lcr began decreas week compar week follow p plt posit correl white blood cell neutrophil week follow posit correl high sensit c reactiv protein week follow oper p | D001792;D063847 | T025;T059 |
34,689,520 | daratumumab treatment primari system amyloidosi multicent retrospect analysi object analyz efficaci safeti daratumumab treatment primari al light chain system amyloidosi method twenti one patient diagnos primari al light chain system amyloidosi treat daratumumab center retrospect analyz daratumumab administr first line therapi seven patient patient relaps set hematolog respons safeti surviv analyz result patient achiev good partial respons vgpr better first line applic daratumumab three patient die four achiev organ remiss among relaps patient patient differ free light chain dflc less mgl treatment dflc mgl patient reach partial respons pr better includ patient complet respons cr vgpr pr respons rate patient dflc mgl baselin organ remiss rate patient heart involv patient kidney impair overal median follow period month month surviv patient one patient die sever infect dissemin intravascular coagul dic stabl amyloidosi one patient switch regimen dflc elev fulfil progress diseas year applic safeti grade infus reaction develop grade infus reaction occur case first infus lymphocytopenia seen patient includ grade patient conclus daratumumab effect elimin serum free light chain newli diagnos relaps patient system amyloidosi | D000075363 | T191 |
34,689,519 | effect liraglutid bodi composit muscl strength adult obes patient type diabet mellitus object aim present studi observ effect liralutid bodi composit muscl function adult obes patient type diabet method total adult obes type diabet patient year age bodi mass index bmi kgm enrol patient random assign two group basi maintain origin hypoglycem regimen patient control group n given dietari guidanc treatment group n inject liraglutid patient follow period week blood glucos glycosyl hemoglobin hbac insulin level liver kidney function bodi composit assess electr imped method grip strength measur grip meter muscl function detect baselin end studi result compar control group reduct hbac vs bodi weight kg vs kg bodi fat mass kg vs kg viscer fat area cm vs cm pronouc liraglutid treat group p howev chang could observ muscl mass grip strength liraglutid treatment conclus addit reduc blood glucos bodi weight fat mass treatment lilaluptid impact muscl mass muscl function therefor liralutid suitabl obes patient type diabet especi weight manag patient risk muscl loss | D003924;D000069450 | T116;T047;T121;T109;T125 |
34,689,518 | exposur antibiot erad bismuth quadrupl therapi hpylori infect object analyz impact previous exposur macrolid quinolon nitroimidazol antibiot erad rate bismuth quadrupl therapi bqt newli diagnos patient helicobact pylori h pylori method total patient h pylori initi treat third hospit peke univers septemb august retrospect recruit therapeut regimen bqt contain clarithromycinlevofloxacinmetronidazol recommend chines guidelin clinic data collect includ general demograph data exposur histori antibiot cypc metabol pattern endoscop diagnosi bacteri densiti hpylori resist erad result etc univari analysi chi squar test fisher exact probabl test kruskal walli h test logist regress model use statist method result among differ erad therapi univari multivari analys suggest previous exposur macrolid ci p relev decreas erad rate bqt contain clarithromycin may due increas resist clarithromycin ci p previous exposur quinolon ci p relev decreas erad rate bqt contain levofloxacin probabl explain increas resist levofloxacin ci p previous histori nitroimidazol impact efficaci bqt contain metronidazol conclus patient newli diagnos hpylori infect previous exposur macrolid quinolon antibiot relat lower eradi rate h pylori although exposur nitroimidazol also indic drug resist metronidazol clinic efficaci bqt metronidazol mg four time day affect | D016481;D016480 | T007;T047 |
34,689,517 | influenc first line endovascular treatment clinic outcom patient acut vertebrobasilar arteri occlus object compar effect first line mechan thrombectomi mt type endovascular treatment evt patient acut vertebrobasilar arteri occlus vbao method may decemb acut vbao patient diagnos angiograph examin consecut enrol nanj stroke registri patient divid first line mt group treat stent retriev direct aspir type evt group underw intraarteri thrombolysi tirofiban infus balloon dilat stent placement etc clinic characterist baselin statist trend p differ group analyz calcul propens score adjust binari logist regress relationship first line treatment clinic outcom result total patient enrol studi includ male femal averag age year old overal recan rate follow patient achiev good outcom defin modifi rankin scale score day year respect mt group receiv evt earlier type evt group median year vs p well higher proport atrial fibril histori vs p higher baselin nation institut health stroke scale score median vs p lower glasgow coma scale score median vs p longer estim occlus groin punctur time median min vs min p signific differ stroke etiolog two group p mt group lower ratio rescu devic treatment vs p propens score adjust recan rate mt group signific higher group odd ratio confid interv ci ci p differ note regard clinic outcom subgroup analysi indic recan rate patient without atherosclerosi differ intervent type odd ratio ci ci p recan rate compar popul atherosclerosi odd ratio ci ci p conclus acut vbao patient first line mt associ higher recan rate compar type evt especi non atherosclerosi patient | D057510;D020521;D014715 | T047;T061 |
34,689,516 | effect posit end expiratori pressur central venous pressur patient differ chest wall elast resist object investig role chest wall elast resist determin effect posit end expiratori pressur peep central venous pressur cvp patient mechan ventil mv method prospect studi accord median ratio chest wall elast resist respiratori system elast resist er patient divid high chest wall elast resist group ecwer low chest wall elast resist group elast chest wall ecw er peep set cmh cmh kpa respect clinic data includ cvp heart rate hr blood pressur bp respiratori mechan record result seventi patient receiv mv includ novemb decemb clinic characterist includ age bp hr baselin peep ratio arteri oxygen partial pressur fraction inspir oxygen pf comorbid compar two group howev patient high ecwer ratio present higher bodi mass index bmi low ecwer ratio kgm vs kgm p peep increas cmh cmh cvp high ecwer group increas signific compar low ecwer group mmhg mmhgkpa vs mmhg p peep increas cmh cmh mmhg vs mmhg p peep increas cmh cmh mmhg vs mmhg p peep increas cmh cmh cmh cmh cmh cmh signific correl ecwer cvp elev r p r p r p respect conclus patient receiv mechan ventil elev peep lead synchron chang cvp corel patient chest wall elast resist | D035441 | T023 |
34,689,515 | interpret guidelin manag diabet mellitus elder china edit elder diabet patient china account one fourth total number elder diabet patient world rank first worldwid nation center gerontolog chines societi geriatr diabet profession committe chines age well associ issu china first guidelin elder diabet patient guidelin manag diabet mellitus elder china edit present articl interpret part import recommend guidelin aim facilit implement clinic practic effect improv clinic prognosi elder diabet patient countri | D003920 | T047 |
34,689,514 | recommend medic rheumat diseas periconcept period rheumat diseas kind chronic inflammatori diseas main involv joint surround tissu patient rheumat diseas need long term treatment difficult avoid pregnanc treatment efficaci well matern fetal safeti taken account medic decis base domest foreign guidelin consensus diagnosi treatment experi chines rheumatolog associ develop standard medic use patient rheumat diseas prepar pregnanc aim applic precaut common use medicin rheumat diseas prepar pregnanc pregnanc lactat | D012216;D012219 | T091;T047 |
34,689,512 | intervent treatment chronic airway diseas new era come | D000402;D029424;D014135 | T047;T046 |
34,689,511 | medial posterior compress distal femor vein underus approach detect venous thrombosi null | D005268;D020246 | T047;T023;T046 |
34,689,510 | cross cerebellar diaschisi child status epilepticus null | D002526;D013226 | T047 |
34,689,509 | philadelphia chromosom posit b lymphoblast leukemia infant null | D010677;D054198 | T191;T046 |
34,689,508 | shank fgfr novel fgfr rearrang patient intestin adenocarcinoma null | D000230;D051496 | T192;T191;T116;T126 |
34,689,507 | clinic find pheochromocytoma null | D000310;D010673 | T191 |
34,689,506 | case primari undifferenti pleomorph sarcoma lung null | D051677 | T191 |
34,689,505 | foreign bodi granuloma secondari retain toothbrush head null | D005547;D015745 | T046;T072;T037;T020 |
34,689,504 | influenc oprm ag polymorph dosag morphin patient advanc liver cancer studi conduct investig influenc opioid receptor gene oprm ag polymorph dosag morphin advanc liver cancer patient seventi patient advanc liver cancer changyi peopl hospit shandong provinc china includ februari decemb dosag morphin patient oprm ag differ genotyp compar thirti patient aa genotyp ag genotyp gg genotyp signific differ morphin dosag within first hour patient aa ag gg genotyp p morphin dosag patient gg genotyp highest conclus oprm ag genotyp may affect dosag morphin advanc liver cancer patient dosag morphin need pain control patient g allel key word opioid receptor gene oprm gene polymorph liver cancer morphin | D008113;D009020 | T191;T121;T109 |
34,689,503 | impact covid pandem treatment pediatr oncolog patient report resourc limit set aim studi determin covid pandem impact effect manag outcom pediatr oncolog patient shaukat khanum memori cancer hospit research centr lahor data retrospect review march june approv institut review board committe total patient activ oncolog treatment studi period includ total number patient whose treatment affect patient receiv treatment time total patient relaps patient treatment delay patient treatment delay n remiss patient abscond covid pandem caus sudden impedi treatment pediatr oncolog patient like affect long term surviv outcom pediatr oncolog patient key word chemotherapi radiotherapi surgeri long term outcom | D000086382;D009369 | T191;T047;T067 |
34,689,502 | mri base diagnosi anterior talofibular ligament injuri aim studi explor valu magnet reson imag mri diagnosi anterior talofibular ligament injuri eighti two patient diagnos anterior talofibular ligament injuri patholog examin oper includ mri show case complet ruptur case tear case avuls fractur accuraci mri diagnosi anterior talofibular ligament injuri case compar patholog examin oper differ statist insignific p accuraci mri diagnosi anterior talofibular ligament injuri high import clinic valu earli diagnosi anterior talofibular ligament injuri key word anterior talofibular ligament injuri magnet reson imag mri diagnosi | D016512;D050723;D017844 | T023;T037 |
34,689,501 | case lung abscess mimick lung cancer radiolog appear lung abscess nonspecif masquerad mass lesion earli phase treatment primarili medic surgic treatment necessari size larger cm patient show indic massiv hemoptysi empyema bronchial obstruct risk cancer medic treatment fail year male patient present complaint back pain period two year addit complaint fatigu cough blood physic examin crackl right upper zone lung observ chest x ray reveal cavitari lesion right upper zone patient taken hospit preliminari diagnosi lung cancer fiberopt bronchoscopi fob perform result preliminari diagnosi malign endobronchi lesion detect fob bronchoalveolar lavag bal cultur negat bal cytolog also benign result oral levofloxacin treatment start follow examin partial reduct size caviti observ result observ pet ct order accord result f fluorodeoxyglucos fdg uptak level maximum standardis uptak valu suvmax suspici malign note right hilar lymph node associ irregular lobul mass consid associ pleura posterior segment right upper lobe patient taken surgeri light find patholog result consist abscess patient complaint six month surgic oper key word lung abscess cavitari lesion lung cancer pet scan | D008169;D008175 | T191;T047 |
34,689,500 | primit neuroectoderm tumor testi year male present left testicular mass retroperiton lymphadenopathi underw radic orchiectomi patholog examin show mix germ cell tumor compos primit neuroectoderm tumor mix matur teratoma six cycl ie ifosfamid etoposid vac vincristin doxorubicin cyclophosphamid chemotherapi given sperm preserv underw retroperiton lymph node dissect rplnd tumor detect remov lymph node lymph node report show reactiv chang key word chemotherapi primit neuroectoderm tumor surgeri teratom testi | D009373;D018242;D013724;D013736 | T191 |
34,689,499 | use eculizumab thrombot microangiopathi associ hematopoiet stem cell transplant thrombot microangiopathi tma associ hematopoiet stem cell transplant remain difficult complic due high mortal rate lack standardis diagnost criteria limit treatment option although etiolog diseas clear medic radiotherapi graft versus host diseas gvhd angioinvas fungal viral infect complement activ implic agent therapeut plasma exchang tpe steroid rituximab defibrotid eculizumab use treatment use treatment tpe steroid defibrotid rituximab yield satisfactori result transplant associ tma ta tma recent studi report success result eculizumab treatment ta tma standard dose eculizumab treatment ta tma dose use atyp hemolyt urem syndrom ahus administ paper present case unrespons tpe steroid success treat eculizumab key word acut myeloid leukemia stem cell transplant thrombot microangiopathi apheresi eculizumab | D006086;D018380;D057049 | T047;T061 |
34,689,498 | rare case posterior inteross nerv palsi post venepunctur wrist drop post venepunctur uncommon report case direct injuri radial nerv venepunctur knowledg never case posterior inteross nerv pin injuri year femal right hand domin homemak newli diagnos diabet mellitus admit diabet ketoacidosi difficult access multipl attempt blood take antebrachi fossa forearm thereaft unabl fulli extend wrist finger thumb intact sensat electrophysiolog studi suggest demyelin right radial neuropathi elbow despit transient blood take session patient develop neuropraxia resolv four month wish report case unusu present pin palsi post routin venepunctur result high morbid patient key word posterior inteross nerv syndrom venepunctur neuropraxia wrist drop | D005542;D020425 | T037;T047;T023;T033 |
34,689,497 | case foveoschisi associ ornithin aminotransferas defici gyrat atrophi gyrat atrophi metabol disord characteris typic progress circular chorioretin atrophi myopia earli development cataract diseas caus defici ornithin aminotransferas oat enzym although oat express tissu bodi main target diseas appear retina case present year woman came clinic complaint declin central vision eight month progress poor night vision diagnos oat defici five year ago system histori unremark except femor deep vein thrombosi dvt occur two year ago laboratori test perform time reveal elev serum ornithin low serum lysin level optic coher tomographi oct scan show foveoschisi bilater summari gyrat atrophi may present macular involv form foveoschisi may lead impair central vision key word foveoschisi gyrat atrophi ornithin aminotransferas | D015799 | T047 |
34,689,496 | adult retroperiton matur cystic teratoma masquerad non endocrin primari adren tumor teratoma belong non seminomat germ cell tumor origin totipot germ cell most made tissu deriv three layer ie endoderm mesoderm ectoderm matur teratoma benign immatur teratoma malign potenti extra gonad matur cystic teratoma uncommon particular retroperitoneum site sacrococcyg mediastin pineal region most detect femal reproduct age group case report discuss femal patient work persist vomit food indigest initi manag line acid peptic diseas found larg retroperiton mass adren region produc mass effect intestin later discov matur cystic teratoma histopatholog evalu key word matur teratoma adren gland retroperitoneum | D000310;D003884;D009373;D013724 | T191 |
34,689,495 | chang anterior len epithelium basement membran pseudoexfoli syndrom undergo surgeri senil cataract transmiss electron microscop studi compar electron microscop len find without pseudoexfoli syndrom xfs patient undergo surgeri senil cataract | D002386;D017889 | T190;T033;T047 |
34,689,494 | preval anemia associ risk factor among pregnant women role antenat care prevent cross section studi determin preval anemia associ factor pregnant women effect famili medicin practic antenat care servic provid famili physician prevent anemia pregnanc | D000740;D011250 | T047 |
34,689,493 | insulin heparin therapi acut pancreat due hypertriglyceridemia compar insulin infus heparin infus use treat hypertriglyceridemia induc acut pancreat term efficaci | D015228;D010195 | T047;T046 |
34,689,492 | assess learn process laparoscop sleev gastrectomi differ approach determin learn curv lc laparoscop sleev gastrectomi lsg base excess weight loss ewl | D010535;D009767 | T061;T047;T060 |
34,689,491 | effect secondari hyperparathyroid circadian blood pressur hemodialysi patient determin relationship secondari hyperparathyroid shpt circadian blood pressur bp rthym among patient undergo hemodialysi treatment | D006962;D006973 | T047 |
34,689,490 | long term function differ first second knee simultan bilater total knee arthroplasti compar long term function result first second knee simultan bilater total knee arthroplasti | D019645;D007720;D020370 | T047;T074;T061 |
34,689,489 | impact muscl mass deplet surgic outcom patient primari high grade serous ovarian cancer undergo crs hipec investig effect sarcopenia surgic outcom patient primari high grade serous ovarian cancer undergo cytoreduct surgeri hypertherm intraperiton chemotherapi crs hipec | D006979;D010051;D010534 | T191;T061 |
34,689,488 | cytoreduct surgeri versus system chemotherapi alon isol periton carcinomatosi colorect origin compar overal surviv progress free surviv front line cytoreduct surgeri crs hypertherm intraperiton chemotherapi versus intens system chemotherapi alon patient isol periton carcinomatosi colorect origin | D015179;D006979;D010534 | T191;T061 |
34,689,487 | serum hepcidin prohepcidin level nonfebril febril neutropenia compar prohepcidin hepcidin level afebril neutropen period neutropen fever patient hematolog malign | D064147;D064451 | T125;T047;T116;T123 |
34,689,486 | frequenc specif gene differ type epilepsi determin diagnost import use exom base multigen panel childhood epilepsi | D004827 | T033;T047 |
34,689,485 | relationship polycyst ovari syndrom serum periostin level determin chang circul periostin level polycyst ovari syndrom pcos relationship metabol disord | D007333;D008659;D011085 | T047;T046 |
34,689,484 | relationship decorin vegf endometriosi evalu immunohistochem ihc stain decorin vascular endotheli growth factor vegf ovarian endometri tissu patient without endometriosi studi design descript studi | D004715;D042461 | T191;T047;T116;T123 |
34,689,483 | serum amino acid level mortal patient undergo percutan endoscop gastrostomi evalu effect feed via percutan endoscop gastrostomi tube peg serum amino acid level mortal | D005774;D044342 | T047;T061 |
34,689,482 | inferior vena cava collaps index central venous pressur fluid assess critic ill patient determin correl sonograph evalu inferior vena cava diamet collaps index central venous pressur spontan breath mechan ventil patient surgic icu studi design cross section studi | D016638;D014682 | T023;T047 |
34,689,481 | implant left bundl branch area pace patient without bundl branch block investig clinic safeti electrocardiogram ecg characterist patient left bundl branch area pace lbbap | D002037;D054088 | T023;T047;T046 |
34,689,480 | clinic outcom physiolog guid revascularis assess clinic outcom revascularis base fraction flow reserv ffr andor instantan wave free ratio ifr | D023921;D053805 | T047;T201 |
34,689,472 | research progress mechan wound skin dys pigment burn burn wound heal often show certain degre pigment disord may caus cosmet psycholog issu affect patient normal social activ also increas risk skin cancer photoag although normal skin pigment fair well studi mechan lead dyspigment burn injuri need explor base summar mechan normal skin pigment paper review latest research progress postburn dyspigment recent year | D002056;D010859;D017695 | T047;T019;T037 |
34,689,471 | research advanc autolog hair transplant treatment secondari cicatricail alopecia secondari cicatrici alopecia hereinaft refer cicatrici alopecia burn trauma affect aesthet appear even physic mental health patient reduc qualiti life happi autolog hair transplant provid idea treatment cicatrici alopecia make transplant hair show natur growth state paper introduc cicatrici alopecia autolog hair transplant review applic limit autolog hair transplant treat cicatrici alopecia | D000505;D011788 | T047;T078 |
34,689,470 | research advanc applic platelet concentr product wound repair multipl growth factor requir regul wound repair process current still lack potent durabl inexpens growth factor product clinic practic meanwhil platelet concentr product provid econom conveni effect choic treatment wound clinic practic start first generat platelet concentr product platelet rich plasma research focus optim perform platelet concentr product higher stabil abund bioactiv factor optim clinic perform platelet rich fibrin concentr growth factor emerg sinc platelet concentr product effect promot speed wound heal enhanc qualiti articl aim summar histori classif platelet concentr product compar properti clinic applic elabor mechan action analyz problem exist relev research prospect futur develop field | D000073183;D053657 | T031;T122 |
34,689,469 | explor studi immobil effect full thick skin subcutan graft allogen full thick skin graft rat object investig immobil effect full thick skin subcutan graft allogen full thick skin graft rat method experiment research method use inbr male brown norway rat n lewi rat n use donor recipi respect subcutan full thick separ cm cm area nape recipi rat full thick skin cm cm taken abdomen donor rat subcutan graft donor site pull togeth sutur autolog skin allograft recipi rat excis graft stitch remov excis within month graft feed activ surviv donor recipi rat behavior tear scratch wound recipi rat wound condit autolog skin excis recipi rat surviv hair growth graft allogen skin observ result within month graft donor recipi rat ate normal could move freeli abnorm death tear scratch wound occur recipi rat small amount exud partial epiderm desquam autolog skin excis recipi rat transplant allograft surviv free infect necrosi new hair grow smooth conclus immobil method full thick skin subcutan graft allogen full thick skin graft rat simpl time save without postop dress chang reliabl pressur fixat high surviv rate skin graft promot anim skin graft model | D018380;D016038 | T061 |
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