PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,678,652 | bionanohybrid compos metalloproteindnamo peptid control intracellular redox state live cell applic cell base biomemori devic develop cell base bioelectron devic larg depend direct control intracellular redox state howev relat studi focus accur measur electr signal live cell wherea direct intracellular state control remain larg unexplor develop biocompat transmembran bionanohybrid structur compos recombin metalloprotein dna molybdenum disulfid nanoparticl mos peptid control intracellular redox state use cell base biomemori devic use capacit mos locat insid cell bionanohybrid control intracellular redox state live cell record extract intracellular charg inturn achiev activ write deactiv eras cell proof concept cell base biomemori function includ write read eras success demonstr confirm via electrochem method patch clamp analys result develop first vitro cell base biomemori devic newli develop bionanohybrid provid novel approach control cellular redox state cell base bioelectron applic applic wide rang biolog field includ bioelectron medicin intracellular redox status regul | D015374;D008667 | T123;T116;T059;T075 |
34,678,651 | metal organ framework assist nonenzymat cascad amplif multiplex strategi sens acut myocardi infarct relat microrna amplif strategi multipl microrna mirna detect pivot acut myocardi infarct ami herein ration develop metal organ framework assist nonenzymat cascad amplif strategi simultan quantif three ami relat mirna mir mir mir fluoresc elabor design dna molecular beacon respect modif fam tamra cy termin quench metal organ framework name fe mil target mirna appear hybrid correspond dna molecular beacon catalyz hairpin assembl cha reaction would trigger produc shape three branch duplex nanostructur target releas initi subsequ anoth cycl shape nanostructur could adsorb onto surfac fe mil due weaker affin fe mil shape nanostructur therefor fluoresc shape nanostructur could quench fe mil way three ami relat mirna simultan detect respect rang nm nm nm respect limit detect pm furthermor method success employ determin three ami relat mirna human serum strategi offer great opportun ultrasensit detect multipl ami relat mirna substanti improv accuraci clinic earli ami diagnosi | D015374;D000073396;D035683;D009203;D049329 | T047;T109;T123;T073;T114;T075;T059 |
34,678,650 | drug elut immun checkpoint blockad antibodi nanoparticl conjug enhanc locoregion system combin cancer immunotherapi lymphocyt target multipl small molecul immun modul identifi synergist immun checkpoint blockad icb effect lymphocyt limit success applic combin cancer immunotherapi due short vivo retent lack affin cell engin antibodi nanoparticl conjug anc platform consist nm polym nanoparticl due size formul effici distribut administr lymph node tissu high enrich lymphocyt contribut tumor control mediat icb display monoclon antibodi surfac express cell marker np deliveri vivo circul lymph node resid lymphocyt substanti enhanc deliveri small molecul formul np passiv encapsul use icb monoclon antibodi target moieti signal block therapeut anc improv local system anti tumor effect small molecul tgf receptor inhibitor adenosin antagonist administ either locoregion system circul two syngen aggress tumor model slow tumor growth prolong anim surviv benefit lost absenc anc target co formul strategi enabl target co deliveri multipl immunotherapeut lymphocyt high potenti improv icb cancer immunotherapi concurr inhibit non redund suppress pathway | D053758;D009369;D004364 | T191;T121;T073 |
34,678,649 | self assembl semiconduct polym base hybrid nanoag synergist tumor treatment impend need develop carrier free nanosystem singl laser trigger activ phototherapi approach overcom drawback associ irradi two distinct laser sourc avoid prolong treatment time complex treatment protocol herein develop self assembl nanosystem scp cs consist new semiconduct polym scp encapsul ultrasmal cus cs nanoparticl scp compon display remark near infrar nir induc phototherm abil enhanc reactiv oxygen speci ros generat incred photoacoust pa signal upon activ nm laser phototherapi mediat cancer ablat cus compon improv pa imag abil scp cs also enhanc photo induc chemodynam efficaci attribut promot singl laser trigger hyperthermia enhanc ros generat scp cs nanosystem show effect intracellular uptak intratumor accumul enhanc tumor suppress reduc treatment time devoid notic toxic | D006979;D053758;D009369 | T191;T073;T061 |
34,678,648 | new semi orthotop bone defect model cell biomateri test regen medicin recent decad increas number tissu engin bone graft develop howev expens labori screen vivo necessari assess safeti efficaci formul rodent first choic initi vivo screen size limit dimens number bone graft test orthotop locat report develop refin murin subcutan model semi orthotop bone format allow test four graft per mous one order magnitud greater volum current possibl mice crucial defect also critic size unabl heal within timefram studi without intervent model base four bovin bone implant ring shape bone heal potenti distinct graft evalu vivo studi demonstr promot prevent ossif assess model use semi automat algorithm longitudin micro ct imag registr follow histolog analys taken togeth data support model suitabl platform real time screen bone format provid possibl studi bone resorpt osseointegr vascularis | D001861;D044968 | T091;T042 |
34,678,647 | system toll like receptor agonist cpg oligodeoxynucleotid exacerb aminoglycosid ototox toll like receptor tlr signal pathway key regul innat immun system respons system infect sever studi report system tlr agonist lipopolysaccharid exacerb aminoglycosid ototox influenc virus associ tlr tlr signal cascad cochlea unclear present studi aim investig auditori effect system tlr tlr agonist chronic kanamycin treatment cbacaj mice receiv tlr agonist gardiquimod tlr agonist cpg oligodeoxynucleotid odn one day kanamycin inject th th day day cours kanamycin treatment observ system gardiquimod cpg odn alon affect baselin auditori brainstem respons abr threshold three week kanamycin treatment gardiquimod signific chang abr threshold shift wherea cpg odn signific increas kanamycin induc abr threshold shift furthermor outer hair cell ohc evalu reveal cpg odn reduc distort product otoacoust emiss amplitud increas kanamycin induc ohc loss cpg odn signific elev cochlear irf tnf il il transcript level addit increas number iba cell repres activ macrophag observ cochlea treat cpg odn result indic system cpg odn exacerb kanamycin induc ototox increas cochlear inflamm studi impli patient under virus infect may experi sever aminoglycosid induc hear loss occur | D000081015 | T047;T046 |
34,678,646 | volunt transit chang qualiti life among older adult mix method research activ theori posit product activ benefici older peopl well studi examin qualiti life qol global differ dimens may affect stop initi volunt psychosoci mechan might work associ | D011788;D014838 | T097;T054;T078 |
34,678,645 | develop predict model beta hydroxybutyr non esterifi fatti acid use milk fourier transform infrar spectroscopi dairi cow negat energi balanc follow parturit predispos dairi cattl numer metabol disord current diagnost limit labor requir inabl measur multipl metabol marker simultan fourier transform infrar spectroscopi ftir data measur milk sampl could improv detect metabol disord use routin milk sampl dairi farm object studi develop predict model numer valu blood beta hydroxybutyr bhb blood non esterifi fatti acid nefa studi util dataset compris observ known blood bhb blood nefa valu measur concurr milk ftir data use elasticnet regress milk ftir data product inform built regress model numer blood bhb blood nefa predict classif model blood bhb valu greater mmoll blood nefa valu greater mmoll r best fit model log transform bhb log transform nefa respect bhb classif model sensit specif nefa classif model achiev sensit specif appli numer predict model extern dataset n known blood metabolit valid predict accuraci log transform blood bhb log transform blood nefa model log transform bhb root mean squar error rmse log transform nefa rmse second object studi develop categor cow either metabol disord healthi respons negat energi balanc transit cow relat blood level bhb nefa cow suffer metabol disord without elev blood bhb valu remain unidentifi detect focus blood bhb alon account differenti metabol respons categor cow either metabol healthi suffer metabol disord use combin blood bhb blood nefa milk fat protein quotient obtain balanc accuraci predict cow metabol status direct predict metabol status use identifi hyperketonem cow addit cow exhibit metabol respons pattern detect elev blood bhb alon | D005230;D008892 | T031;T168;T109 |
34,678,644 | aahi chip seq base transient express system reveal role aawrki artemisinin biosynthet gene regul chip seq chromatin immunoprecipit sequenc gold standard determin genom wide vivo transcript factor bind site first step target predict network construct non model plant challeng perform chip seq due difficulti generat stabl transgen plant aahi posit regul artemisinin biosynthesi whose detail mode action remain elus establish protoplast transform procedur artemisia annua optim differ condit protoplast isol transfect perform aahi chip seq base establish transient express system combin rna seq data various tissu identifi four transcript factor one myb three wrki famili member aahi target potenti regul artemisinin biosynthesi three wrki transcript factor could induc light overexpress aahi upregul two artemisinin biosynthet gene ad cypav furthermor aawrki show transcript activ activ artemisinin biosynthet gene cypav togeth aawrki identifi potenti transcript factor link aahi artemisinin biosynthet gene regul | D031172;D037621 | T002;T109 |
34,678,643 | diagnost inform base framework super resolut qualiti assess retin oct imag high resolut hr retin optic coher tomographi oct imag prefer ophthalmologist diagnos retin diseas imag obtain dens scan target retin region acquisit howev dens scan increas imag acquisit time introduc motion artefact corrupt diagnost inform therefor research grow interest develop imag process techniqu recov hr imag low resolut lr oct imag paper present autom super resolut sr scheme use diagnost inform weight spars represent framework reconstruct hr imag lr oct imag propos method perform fast reliabl reconstruct lr imag also propos variat mode decomposit vmd base oct diagnost distort measur q oct quantifi diagnost distort reconstruct oct imag sr method evalu clinic grade oct imag propos diagnost distort measur along convent non diagnost measur like contrast nois ratio cnr equival number look enl peak signal nois ratio psnr result show averag cnr enl psnr db averag score obtain use propos diagnost distort measur experiment result quantifi propos q oct metric effect captur diagnost distort | D012164;D041623 | T047;T060 |
34,678,642 | role hydroxymethylglutaryl coenzym hmg coa reductas nodul develop soybean autoregul nodul aon play central role nodul inhibit format excess number legum root nodul studi effect hydroxymethylglutaryl coenzym reductas gmhmgr gene express nodul aon system glycin max l merr investig wild type soybean cultivar bragg near isogen supernodul mutant nitrat toler symbiot nts select identifi express pattern gene rootlet inocul microsymbiont bradyrhizobium analysi full length gmhmgr promot clone amplif invers pcr bac librari screen also construct intron hairpin rna interfer ihprnai gmhmgr promot glucuronidas fusion construct consequ suppress gmhmgr histochem analysi transgen soybean hairi root induc agrobacterium rhizogen strain k gmhmgr gene function earli stage nodul aon system negat effect gmhmgr express nodul format wild type rootlet gmhmgr particular express develop phloem within root nodul nodul lenticel express gmhmgr transgen hairi root suppress rnai silenc approxim compar empti vector control suggest gmhmgr gene import role trigger nodul format suppress caus reduct nodul format nts mutant line defici aon system | D025782;D010940;D055170;D013025 | T040;T116;T126;T168 |
34,678,637 | long term exposur pm guidelin exacerb covid sever mortal age sex race comorbid insuffici explain individu remain asymptomat sar cov infect other die sens increas risk caus long term exposur air pollut investig understand high heterogen covid infect cours | D000393;D000397;D000086382 | T047;T131;T067;T080;T069 |
34,678,636 | effect sexual self schema sexual embarrass nurs student attitud belief student relat sexual health sexual health need one holist care need nurs need help individu identifi meet need howev sometim percept sexual affect attitud toward care aim studi determin effect sexual self schema sexual embarrass attitud belief relat sexual health nurs student | D000074384;D013338 | T097;T032 |
34,678,635 | mentor programm meet newli graduat nurs need give senior nurs new career opportun multipl case studi evalu implement multifacet mentor programm larg univers hospit describ valu perspect newli graduat nurs experienc nurs hospit organis | D000071252;D009718;D009726 | T097;T065 |
34,678,634 | alter amino acid metabol intestin microbiota chines mitten crab eriocheir sinensi fed formul diet ice trash fish formul diet fd ice trash fish itf common diet e sinensi farm howev whether fd complet replac itf long term e sinensi farm still unclear thus studi conduct compar differ amino acid metabol intestin microbiota e sinensi fed differ diet crab random divid three group fed fd itf mix diet md fd itf respect result show signific differ amino acid composit among fd md itf group activ ast alt mrna level amino acid metabol relat gene signific regul fd orand md group compar itf group divers intestin bacteri communiti similar fd itf group relat abund domin taxa show mark differ two group phylum level relat abund firmicut signific higher relat abund proteobacteria signific lower fd group itf group meanwhil genus level relat abund candidatushepatoplasma fd higher itf group data relat function predict demonstr signific differenc pathway two group observ metabol pyrimidin metabol glycolysisgluconeogenesi citrat cycl environment inform process transport overal result indic replac itf fd affect amino acid composit alter amino acid metabol relat abund intestin microbiota data provid valuabl refer fd applic replac itf long term e sinensi farm | D000069196 | T007;T001 |
34,678,633 | health anxieti attent control interact predict uncertainti relat attent bias current theori health anxieti grow bodi empir literatur suggest high health anxieti symptom might find uncertainti threaten demonstr attent bias uncertainti relat inform abu moreov dual process model attent would suggest individu differ attent control might modifi relationship present studi design explor propos health anxieti abu relationship also consid attent control moder theoret clinic relev | D000070379 | T041 |
34,678,632 | correl laboratori base vicari threat learn emot disord symptom dimens vicari threat condit abnorm theoriz confer vulner wide rang emot problem test two differ conceptu model non specif first hypersensit social condit danger cue might predict stand general intern dimens repres common among various form anxieti depress second hypersensit might predict specif symptom cluster panic social anxieti | D003214;D007753 | T073;T093;T041 |
34,678,631 | examin impair distress food addict across demograph weight group rate food addict fa vari across weight demograph group factor influenc discrep preval rate larg unknown rate clinic signific distress impair also vari across demograph group yet prior studi overlook diagnost signific distressimpair heterogen group test weight demograph group differ likelihood endors distressimpair fa particip n recruit amazon mechan turk complet modifi yale food addict scale myfa myfa includ dichotom symptom indic one dichotom distressimpair indic differ distressimpair test across weight sex racialethn educ group use logist regress fa sever control use fa symptom count differ among racialethn educ group p compar men women like report distressimpair aor ci peopl obes like report distressimpair compar peopl overweight aor ci normal weight aor ci individu characterist ie sex weight may influenc report distressimpair fa inquiri may appropri men peopl normal weight overweight present fa symptom otherwis deni distressimpair | D000073932 | T033;T048 |
34,678,630 | plasma membran local protein bchipp promot uptak copper cadmium planta cadmium cd one toxic heavi metal soil suppress crop product also threaten human health studi aim clarifi biolog function cd relat gene bchipp provid potenti genet solut decreas cd level pak choi tissu express analysi show bchipp express almost plant bodi transcript level bchipp root higher shoot signific induc copper cu defici cd exposur condit subcellular local reveal bchipp local plasma membran express bchipp yeast cell improv sensit cu cd improv accumul yeast furthermor cu cd content arabidopsi seedl increas complement respect express bchipp wild type wt hip mutant non invas micro test technolog nmt use measur real time cd influx root surfac bchipp transgen arabidopsi line result demonstr bchipp promot cd influx arabidopsi root cell taken togeth studi show bchipp contribut absorb nutrient metal cu heavi metal cd planta | D017360;D002104 | T131;T002;T196 |
34,678,629 | effect differ fish feed water qualiti growth crucian carp carassius carassius presenc absenc prometryn data avail regard comprehens quantit assess fish feed consid environment feed impact aim fill gap experiment studi investig effect three fish feed concentr nutrient crucian carp carassius carassius growth conduct laboratori aquarium presenc absenc prometryn result show weight gain rate crucian carp treat tong wei tw feed higher zhong zs zhong liang zl feed possibl explan qualiti protein tw feed highest evidenc protein effici ratio meanwhil tw feed pose relat lighter effect water qualiti zl zs prometryn signific inhibit growth crucian carp thus affect concentr nutrient water indirect relationship weight gain rate fish concentr nutrient water r develop sum studi suggest realiz obtain better fish growth perform lesser degrad effect water qualiti produc select appropri feed regardless prometryn exist develop equat could use basi futur studi | D002347;D011400 | T131;T013;T109 |
34,678,628 | imidacloprid thiamethoxam affect synapt transmiss zebrafish imidacloprid imi thiamethoxam thm two common appli neonicotinoid insecticid imi thm could caus negat impact non target organ like bee howev inform neurotox imi thm fish still scarc investig effect imi thm locomotor behavior ach activ transcript gene relat synapt transmiss zebrafish expos imi thm concentr ng l ng l day post fertil dpf dpf dpf dpf result show imi thm signific influenc locomotor activ larva dpf dpf thm elev ach activ dpf qpcr data reveal imi thm affect transcript marker gene belong synaps dpf dpf furthermor imi thm main affect transcript key gene aminobutyr acid dopamin serotonin pathway larva dpf dpf result demonstr neurotox imi thm zebrafish find studi suggest imi thm aquat environ may pose potenti risk fish fit surviv | D007306;D014874 | T131 |
34,678,627 | di ethylhexyl phthalat dehp exposur suppress communiti divers abund ammonia oxid mitig n emiss alkalin soil phthalic acid ester pae pollut becom increas issu worldwid littl known effect ammonia oxid nitrous oxid n soil environ day soil microcosm experi conduct use low high dose bis ethylhexyl phthalat dehp estim effect dehp exposur soil n emiss nitrifi communiti calcar soil result show dehp exposur mg kg dose signific reduc n respect relat dehp absent treatment microbi biomass carbon nitrogen mbc mbn consist signific decreas dehp exposur day incub especi high dose bipartit associ network show dehp exposur chang composit ammonia oxid archaea aoa ammonia oxid bacteria aob communiti moreov aoa aob amoa gene abund signific decreas dehp addit soil p random forest model show aob shannon index ph import biotic abiot factor affect n emiss soil dehp exposur respect partial least squar path model pls pm demonstr reduct n emiss due dehp exposur main ascrib chang aob communiti result studi highlight toxic dehp ammonia oxid mitig effect n emiss soil ammonia oxid larg driven aob | D000641;D004051 | T121;T122;T197;T109 |
34,678,626 | pre sow seed treatment kinetin calcium mitig salt induc inhibit seed germin seedl growth choysum brassica rapa var parachinensi recent year improv plant resist toward abiot stress exogen applic plant growth regul nutrient emerg matter great interest present studi assess potenti role kinetin kn mm calcium ca mm mitig salt mm nacl induc inhibitori effect seed germin growth choysum seedl result indic nacl stress signific reduc seed germin percentag germin potenti germin index seedl vigor index declin fresh weight dri weight radicl length plumul length germin seed compar control treatment delay germin decreas seedl growth posit correl salin induc hormon imbal ion toxic oxid stress howev kn ca pretreat partial mitig advers effect nacl stress evid earli germin enhanc seedl growth kn ca effect increas accumul prolin solubl protein solubl sugar upregul activ superoxid dismutas peroxidas catalas ascorb peroxidas signific reduc product malondialdehyd hydrogen peroxid superoxid anion germin seed therebi minim nacl induc oxid damag moreov kn ca pretreat counteract nacl induc ionic toxic decreas na increas k content maintain balanc na k ratio radicl plumul choysum seed addit kn ca nacl stress enhanc hormon regul decreas aba level concomit increas gas especi ga level promot earli germin remark co applic kn ca effect complet counteract inhibitori effect nacl maintain seed germin kinet seedl growth biochem paramet almost similar stress free control treatment result demonstr supplement kn ca choysum seed effect chemic strategi regul various physiolog biochem respons would result better germin growth seed stress condit | D029741;D036226 | T168;T002 |
34,678,625 | chemic epigenet manipul trigger product sesquiterpen deep sea deriv eutypella fungus chemic epigenet manipul deep sea deriv eutypella sp fungus co treatment histonedeacetylas inhibitor suberohydroxam acid sbha dna methyltransferas inhibitor azacytidin aza result activ sesquiterpen relat biosynthet gene cluster chromatograph separ elicitor treat cultur led isol sesquiterpen includ undescrib compound eutypeterpen q structur identifi extens analysi spectroscop data includ singl crystal x ray diffract chemic convers calcul nmr ecd data configur assign eutypeterpen first bergamoten type sesquiterpen incorpor dioxolanon unit eutypeterpen q cyclopentan ring repres undescrib subtyp sesquiterpen bioassay result show compound exert inhibitori effect lipopolysaccharid lps induc product raw macrophag eutypeterpen n activ studi demonstr epigenet manipul effect approach trigger product cryptic metabolit deep sea deriv fungus signific inhibit lps induc product vitro suggest eutypeterpen potenti develop anti inflammatori agent | D012717;D013098 | T004;T109 |
34,678,624 | structur elucid spiro cyclohexandienonyl naphthalen potenti anti neuroinflammatori activ caragana acanthophylla kom four undescrib spiro cyclohexandienonyl naphthalen acanthophylla revis compound isol root caragana acanthophylla kom fabacea identifi use extens spectroscop data via chemic method three resolv enantiom absolut configur confirm compar experiment calcul electron circular dichroism spectra moreov anti inflammatori activ compound investig evalu inhibitori effect nitric oxid product lipopolysaccharid stimul bv cell compound show signific inhibitori activ ic valu minocyclin ic indic might serv potenti therapeut agent neurodegen diseas | D032602 | T002 |
34,678,623 | vessel structur stress mediat aortic media degener bicuspid aortopathi new insight base patient specif fluid structur interact analysi studi aim assess relationship local mechan stimuli region aortic tissu degener use fluid structur interact fsi analysi patient bicuspid aortic valv bav diseas nine patient underw ascend aortic replac recruit tissu collect evalu patholog featur four region greater curvatur gc region posterior p region anterior region lesser curvatur lc region fsi analysi perform quantifi vessel structur stress vss flow induc paramet includ wall shear stress wss oscillatori shear index osi particl relat resid time rrt correl biomechan metric tissu degener analyz elastin medial layer media thick thinnest gap fiber biggest gc region follow p region region elastin media thick thickest gap smallest lc region collagen deposit follow pattern biggest gc region least lc region strong negat correl mean peak vss elastin thick arteri wall gc region r p r p region r p r p p region r p r p mean vss fiber distanc region r p moreov strong negat correl mean peak vss media thick also observ correl found wss osi rrt aortic tissu degener four region find indic increas vss correl local elastin degrad aortic media degener impli could potenti biomechan paramet refin risk stratif patient bav | D000082882;D006349 | T047;T019 |
34,678,622 | accent discrimin abil first day life fnir studi human biolog endow faculti languag howev way neonat crack complex communic code yet total understood phonet discrimin wide investig neonat less known role supra segment pattern recognit nativ languag therefor aim studi evalu accent discrimin abil newborn sententi prosodi paradigm use near infar spectroscopi investig accent discrimin full term born infant within first day life sententi prosodi use investig nativ accent b foreign accent c flatten accent neonat reveal signific smaller hemodynam respons nativ accent compar flatten accent foreign accent respect cluster base permut analysi reveal two cluster signific differ two condit nativ accent foreign accent first cluster cover middl superior frontal middl superior tempor central pariet area within left hemispher second cluster locat right hemispher cover inferior middl superior frontal central middl superior tempor area therefor conclud neonat differenti prosod featur like accent within languag day birth | D013067 | T041 |
34,678,621 | captur heterogen life street person center analysi street histori social connect youth heterogen street involv youth examin use person center approach youth classifi base pattern street involv identifi profil compar identifi theoret coher practic signific differ | D018453;D012725 | T032;T053;T098;T055 |
34,678,620 | pre treatment chicken il secret bioengin lab vector protect chicken embryo fibroblast influenza type virus iav infect recent advanc understand host factor orchestr qualit differ immun respons influenza type virus iav chang percept convent approach control avian influenza virus aiv infect chicken given infect induc pathogen replic influenza virus larg reli regul host immun respons immunoregulatori cytokin profil often determin diseas outcom howev contrast function inflammatori cytokin interleukin il describ doubl edg sword indic addit antivir host respons il distinct role promot viral infect therefor present studi investig chicken il mediat antivir immun effect iav infect primari chicken embryo fibroblast cell cef end first bioengin food grade lactic acid produc bacteria lab lactococcus lacti l lacti secret bioactiv recombin chicken il schil next function schil confirm transcript upregul sever gene associ antivir host respons includ granulocyt monocyt coloni stimul factor gm csf csf chicken interleukin il interferon ifn gene primari cef cell consist hypothesi pro inflammatori state may translat immunoprotect iav infect observ schil pre treatment could signific limit viral replic protect primari cef cell two heterotyp iav aturkeywisconsin hn apr hn togeth data present work suggest exogen applic schil secret modifi lab vector may repres altern strategi improv antivir immun avian influenza virus infect chicken | D057005;D019610 | T039;T090 |
34,678,619 | air leak stapl affect porcin lung biomechan thorac oper surgic stapler resect cancer tumor seal spare lung howev post oper air leak undesir clinic consequ stapl leg wound lung tissu subsequ trauma air leak lung tissu pleural space affect lung physiolog patient recoveri object biomechan visual character porcin lung tissu without stapl order gain knowledg air leakag follow pulmonari resect therefor syring pump fill air inflat deflat eleven porcin lung cyclic without exceed cmh pressur camera captur stereo imag deform lung surfac regular interv microcontrol simultan record alveolar pressur volum air pump raw imag use comput tri dimension displac strain digit imag correl method dic air bubbl origin stapl hole inner row expos porcin lung tissu due torn pleural costal surfac compar inflat left upper lower lobe resect similar complianc slope pressur vs volum curv lower healthi lung complianc howev lower lobe statist burst lower pressur upper lobe p valu ex vivo condit confirm previous clinic vivo studi parallel lung deform most vicin stapl hole present maximum shear strain near observ leak locat conclud novel techniqu dic provid concret evid post oper air leak biomechan studi could investig causal relationship mechan paramet develop air leak | D008168;D013528 | T074;T023 |
34,678,618 | microbeam bend hydrat human cortic bone lamella central region bodi femur show viscoelast behaviour bone biolog tissu uniqu mechan properti owe complex hierarch structur rang nanoscal macroscal better understand bone mechan investig mechan properti structur element everi hierarch level interact necessari test bone structur lower microscal eg bone lamella least perform remain challeng focus ion beam fib mill attract techniqu machin microscop sampl bone materi perform mechan test microscal use atom forc microscopi afm nanoindent setup far report studi length scale perform bone sampl anim origin most dehydr state except one studi present afm base microbeam bend method perform bend measur dehydr rehydr condit microscal singl lamella bone microbeam four human donor age yrs machin via fib test air fulli submerg hank balanc salt solut hbss investig effect de hydrat certain extent age bone mechan bend moduli found reduc time h rehydr trend chang bend moduli respect age could observ mechan behavior chang almost pure elast viscoelast upon rehydr trend lower dissip energi sampl older donor could observ rehydr state result confirm direct import water mechan properti bone tissu microscal moreov trend lower capabl energi dissip older donor may contribut decreas fractur tough thus increas bone fragil age | D001842;D005269 | T023;T024 |
34,678,617 | pilot studi investig feasibl supervis machin learn approach classif pedestrian struck vehicl research focus applic artifici intellig ai methodolog problem classifi vehicl involv lethal pedestrian collis specif vehicl type predict basi traumat injuri suffer casualti exploit machin learn algorithm present studi ai assist diagnosi shown correct predict time pedestrian struck truck sever injuri appreci facial skeleton lung major airway liver spleen well sternumclaviclerib complex wherea lower extrem affect fractur pedestrian struck car although distinct strike vehicl develop beyond autopsi evid alon present approach novel realm forens scienc shown effect build autom decis support system outcom system provid valuabl inform execut autopt examin support forens investig preliminari result applic machin learn algorithm real world dataset seem highlight efficaci propos approach could use studi concern topic | D000069636;D014947 | T037;T098 |
34,678,616 | empow antimicrobi photodynam therapi staphylococcus aureus infect potassium iodid infect caus gram posit bacterium staphylococcus aureus especi methicillin resist aureus mrsa impos great burden global healthcar system thus urgent need altern approach fight staphylococc infect target antimicrobi photodynam therapi apdt recent report target apdt aureus specif immunoconjug dx effect appli erad mrsa nonetheless efficaci apdt human bodi may diminish power antioxid activ particular observ efficaci apdt dx toward mrsa reduc human plasma show antagonist effect attribut human serum albumin repres largest pool free thiol plasma trap reactiv oxygen speci import also show target apdt approach dx empow non toxic inorgan salt potassium iodid ki react singlet oxygen produc upon apdt result format free iodin target iodin format allow full erad mrsa log reduct without negat affect non target bacteri speci human cell altogeth show addit ki allow drastic reduct amount immunoconjug dx irradi time need effect elimin mrsa apdt presenc human serum albumin | D010778 | T061 |
34,678,615 | red emit carbon nanoparticl unpreced singlet oxygen generat effici cancer theranost fluoresc red emit carbon nanoparticl rcnps produc econom green hydrotherm method use eucalyptus leav precursor first report kind demonstr rcnps combin pdt chemo combin therapi rcnps bind mitoxantron mto electrostat synthes rcnps conjug mto characteris use dls sem tem uv vis fluoresc ftir h nmr spectroscopi ftir h nmr confirm interact nh proton mto carboxyl acid oxygen rcnps rcnps demonstr bright fluoresc type ii photosensit ps extraordinari quantum yield trigger red laser nm moreov biocompat rcnps rcnps mto examin confirm perform cytotox assay mcf cell line subsequ explor intern process rcnps function concentr confoc imag studi also carri cell viabil apoptosi assay indic rcnps mto achiev pdt chemo synergist cancer therapi best knowledg first time eucalyptus leav natur sourc great abund use raw materi appli combin pdt chemotherapi | D008027;D057285 | T091;T070;T061 |
34,678,610 | accur diagnosi prognosi predict gastric cancer use deep learn digit patholog imag retrospect multicentr studi reduc high incid mortal gastric cancer gc aim develop deep learn base model assist predict diagnosi overal surviv os gc patient use patholog imag | D014408;D000077321 | T066;T123 |
34,678,608 | generic model base properti nanoparticl cell predict cellular uptak nanoparticl nps wide use industri technolog due small size versatil make easi enter organ pose threat human ecolog health given particular complex structur nps statist model alon reliabl predict uptak henc develop generic model predict cellular uptak nps organ coat base physicochem interact under uptak model util concentr experiment condit properti nps viz size surfac coat coverag paramet convert surfac energi compon surfac potenti combin compon potenti cell membran nps uptak construct energet profil barrier adsorpt permeat ontothrough cell membran relationship deriv compar experiment uptak data model provid accur robust uptak estim neutral charg unhalogen nps six differ cell type envis model provid refer cellular accumul neutral nps ecologicalhuman risk assess nps microparticl | D053758 | T073 |
34,678,607 | mental health assess spanish healthcar worker sar cov pandem cross section studi sar cov outbreak pose unpreced care scenario increas psycholog distress among healthcar worker reduc effici health system work evalu psycholog impact covid pandem spanish frontlin healthcar worker two tertiari hospit | D000086382;D003865 | T048;T047;T067 |
34,678,605 | moringa oleifera lam leaf extract safe inhibit periodont regul express pmapk opgrankl periodont chronic diseas clinic defin loss alveolar bone connect tissu degener although moringa oleifera lam mo tree belong moringacea famili wide use anti inflammatori agent effect periodont still unclear work phenol compound mo leaf extract mol identifi uplc esi msms anti periodont effect mechan mol predict use network pharmacolog molecular dock moreov cytotox antioxid anti periodont properti mol confirm vivo vitro total phenol compound potenti mol periodont target screen involv biolog process bp p mapk mapk pathway opgrankl complex predict involv process molecular dock furthermor experiment valid suggest mol signific amelior inflamm reduc alveolar bone resorpt opgrankl ratio regul inhibit mapk anti periodont effect realiz antioxid properti mol hematoxylin eosin h e stain rat vital organ surviv rate raw cell confirm safeti mol present studi provid valuabl insight mol reduc inflamm alveolar bone resorpt associ periodont conclus mol safe inhibit chronic periodont high like regul express pmapk opgrankl network pharmacolog coupl experiment valid effect way find new drug futur data avail statement origin data present studi includ articl inquiri direct correspond author | D016301;D048308;D029588;D010518 | T116;T047;T126;T002 |
34,678,603 | design synthesi vitro silico studi triazol piperazin hybrid deriv potenti mao inhibitor monoamin oxidas mao becom promis drug target develop central nervous system agent recent research shown numer piperazin deriv exhibit hmao inhibitori activ therefor studi novel seri triazol piperazin deriv j design synthes character screen hmao hmao b inhibitori activ adm predict examin seen pharmacokinet profil synthes compound appropri compound b c e h f cl group posit phenyl ring respect show import mao inhibitori activ compound c found effect agent among synthes compound ic valu mao enzym synthes compound appear support result studi design mao inhibitor obtain suitabl drug especi neurolog disord depress anxieti | D015195 | T090 |
34,678,600 | human environment factor drive toxoplasma gondii preval wild boar sus scrofa one relev foodborn diseas essenti know factor relat transmiss persist preval toxoplasma gondii infect eurasian wild boar sus scrofa might play relev role tgondii life cycl speci consum big game anim spain may act sourc infect meat eaten raw undercook due cross contamin addit wild boar act excel bioindic tgondii circul ecosystem natur behaviour lead exposur oocyst soil root tissular bradyzoit scaveng total wild boar sampl mediterranean spain blood sampl test indirect elisa test give total confid interv posit result preval homogen neither anim sampl district signific differ found regard age climat condit human space occup human popul aggreg assess demangeon index identifi influenti factor tgondii infect risk multipl approach allow us evalu local risk human environment contamin | D013553;D014122;D014124 | T204;T047 |
34,678,599 | neural implement bayesian infer bayesian infer emerg general framework captur organ make decis uncertainti recent experiment find reveal dispar mechan brain generat behavior predict normat bayesian theori identifi two broad class neural implement bayesian infer modular class probabilist compon bayesian comput independ encod transform class uncertain measur convert bayesian estim latent process mani recent experiment neurosci find studi probabilist infer broad fall class identifi potenti avenu synthesi across two class dispar present reconcil conclud distinguish among implement hypothes bayesian infer requir greater engag among theoret experiment neuroscientist effort span differ scale analysi circuit task speci | D009488 | T091 |
34,678,598 | effect lead exposur express igfr igfbp pc cell investig effect lead exposur igfr inhibitor ag express igfr igfbp pc cell clear mechan relat protein induc ad regul thus provid theoret guidanc prevent treatment lead poison | D016229;D007854 | T131;T116;T196 |
34,678,594 | gjb mutat ct g ca c induc apoptosi inward rectifi potassium current chang x link charcot mari tooth type gap junction beta gjb pathogen gene x link charcot mari tooth type cmtx rare hereditari sensorimotor neuropathi howev differ mutat gjb result heterogen clinic manifest mutat lead central nervous system involv previous report two gjb missens mutat one novel mutat ct g found cmtx famili manifest peripher neuropathi anoth previous report mutat gjb ca c lead involv peripher nerv cerebr white matter howev mechan gjb mutat lead cmtx fulli character generat schwann cell primari cultur oligodendrocyt two mutat result cx gjb ct g cx kt gjb ca c mutant analyz pathogen mechan use cytolog molecular biolog electrophysiolog method mutant show abnorm endoplasm reticulum aggreg especi cx kt mutant lead increas endoplasm reticulum stress result apoptosi furthermor whole cell patch clamp experi oligodendrocyt reveal cx kt mutant reduc cell membran potenti inward rectifi potassium current may vital element central involv therefor result may provid new perspect understand pathogenesi cmtx | D020125 | T045 |
34,678,593 | protect effect spironolacton vascular calcif chronic kidney diseas vascular calcif common chronic kidney diseas ckd associ increas cardiovascular mortal aldosteron implic augment factor progress vascular calcif present studi explor putat benefici effect aldosteron inhibit mineralocorticoid receptor antagonist spironolacton vascular calcif ckd | D006435 | T061 |
34,678,592 | sexual dimorph express chicken sex chromosom gene vcp reflect differ gonad develop male femal chicken z w sex chromosom system male homogamet sex zz femal heterogamet sex zw smaller w chromosom general consid high degrad copi z chromosom retain around homolog protein code gene z w homologu thought import undefin role develop explor role one gene vcp valosin contain protein gonadogenesi establish rna express level z w vcp homologu level vcp protein cellular local vcp protein male femal embryon gonad develop also assess effect femal male sex revers vcp express develop gonad result show vcp rna protein express higher level femal male gonad express level vcp protein vcp z transcript vcp w transcript decreas femal male sex revers gonad addit spatial express vcp protein differ male femal embryon gonad test vcp protein main confin medullari sex cord ovari vcp protein express throughout medulla higher level cortex result suggest sexual dimorph express chicken vcp reflect differ gonad morpholog sex | D012727 | T032 |
34,678,591 | mutat ppla ii gene encod patatin relat phospholipas caus late flower arabidopsi arabidopsi patatin relat phospholipas ppla ii particip respons various growth condit factor affect ppla ii gene express ppla ii protein activ gycerolipid studi thorough role ppla ii reproduct phase remain unclear effect ppla ii flower time therefor investig ppla ii mutant flower later wild type plant long day condit express floral stimul flower locus ft suppressor overexpress constan soc downregul ppla ii mutant compar express wild type plant express floral repressor flower locus c flc upregul addit express level coldair long intron noncod rna decreas ppla ii mutant taken togeth data indic ppla ii act posit regul flower time repress flc express | D018506 | T045 |
34,678,589 | phosphoryl depend assembl dna damag respons system central role topbp cellular respons dna damag ddr caus replic collaps andor dna doubl strand break characteris massiv chang post translat modif ptm hundr protein involv detect repair dna damag communic state damag cellular system regul replic cell divis substanti proport ptms involv target phosphoryl among effect promot format multiprotein complex specif bind phosphoryl motif one protein specialis domain protein understand natur phosphoryl mediat interact allow definit pathway network coordin ddr help identifi new target therapeut intervent may benefit treatment cancer ddr play key role review summaris present understand phosphoryl motif recognis brct domain occur mani ddr protein particular focus topbp multi brct domain scaffold protein essenti role replic repair signal dna damag | D004268;D009687 | T116;T123 |
34,678,586 | asq trak valid cultur adapt development screen tool australian aborigin children development monitor perform use cultur relev tool critic import young children asq trak cultur linguist adapt age stage questionnair asq development screen tool australian aborigin children asq trak well receiv practic investig psychometr properti enabl profession make inform decis use | D002657;D008403 | T040;T058;T039;T060 |
34,678,583 | finit differ time domain fdtd optic simul primer life scienc bio inspir engin light influenc ecosystem earth sun dappl forest bioluminesc creatur ocean deep biologist long studi nano micro scale organism adapt manipul light use ever sophist microscopi spectroscopi analyt equip combin experiment tool simul light interact object help research determin impact observ structur explor variat affect optic function particular finit differ time domain fdtd method wide use throughout nanophoton communiti effici simul light interact varieti materi optic devic recent fdtd use character optic adapt natur camouflag fish organ color sexual select bird spider photosynthet effici plant fdtd also common bioengin design biolog inspir engin structur guid optim fdtd simul paramet sweep particular use applic fdtd allow research explor rang variabl modif natur synthet system eg investig optic effect chang size shape refract indic structur review use fdtd simul biolog present brief method primer tailor life scientist focus commerci avail softwar lumer fdtd give special attent whether fdtd right tool use experiment techniqu use acquir import structur interest optic properti refract index absorpt obtain primer intend help research understand fdtd implement method model optic effect learn benefit limit tool altogeth fdtd well suit character optic adapt ii provid mechanist explan help iii make conclus evolutionari theori iv inspir new technolog base natur structur | D032701;D017753 | T070;T082;T090 |
34,678,582 | cardiovascular diseas mortal peopl schizophrenia antipsychot treatment cohort studi primari care peopl schizophrenia sz treatment antipsychot drug tad consid high risk cardiovascular cv morbid mortal reason fulli understood addit longitudin studi set primari care spain perform aim analys incid cardiovascular diseas cvd cv mortal popul sz popul without sz tad ns tad | D014150;D002318;D012559 | T039;T047;T121;T048 |
34,678,581 | earlier detect facilit skill respons decept action high skill recreat rugbi player place semi immers caren lab environ examin suscept detect decept achiev broad window seven occlus time use particip respond life size video clip oppos player cut left right without decept sidestep particip made full bodi respons intercept player gave verbal judgement oppon final run direct respons kinemat kinet data record use three dimension motion captur camera forc plate respect base respons accuraci result separ decept suscept decept detect window signal detect analysi use calcul indic discrimin genuin decept action judgement bias c analysi reveal high skill low skill player similar suscept decept howev high skill player detect decept earlier action sequenc enabl make effect behaviour respons decept action | D005538;D009039 | T041;T056 |
34,678,580 | start distanc obstacl circumvent affect intersegment coordin individu parkinson diseas obstacl circumvent challeng task parkinson diseas pd bodi segment adjust chang direct trunk follow chang direct head modif posit feet necessari circumv obstacl walk individu need identifi distanc obstacl characterist dimens perform well coordin movement howev pd character rigid may increas axial axi compromis task execut also worsen sensori integr pd may increas time perform bodi segment adjust thus impair movement coordin start obstacl circumvent near obstacl | D010300 | T047 |
34,678,579 | associ mobil capac mass amount intramuscular non contractil tissu trunk lower extrem muscl communiti dwell older adult examin associ mobil capac muscl thick echo intens trunk lower extrem muscl measur use ultrasound imag devic communiti dwell older adult particip communiti dwell older adult mobil capac assess base measur usual maxim walk speed time go tug time muscl thick echo intens trunk lower extrem muscl measur use ultrasound imag devic final sagitt spinal align assess base measur thorac kyphosi lumbar lordosi sacral anterior inclin angl stand posit use spinal mous stepwis regress analysi show tibiali anterior muscl thick tibiali posterior muscl echo intens bodi weight signific independ factor usual walk speed coeffici determin r thick thorac erector spina obliquus externus abdomini muscl signific independ factor maxim walk speed r moreov age signific independ factor tug time r result studi suggest associ slow usual walk speed low tibiali anterior muscl thick high echo intens tibiali posterior muscl slow maxim walk speed low thorac erector spina obliquus externus abdomini thick communiti dwell older adult | D057187;D060726 | T029;T056 |
34,678,578 | protect effect sulforaphan oxid stress granulosa cell patient polycyst ovari syndrom pcos activ ampkaktnrf signal pathway increas product reactiv oxygen speci ros granulosa cell gcs caus oxid stress os play role pathogenesi polycyst ovari syndrom pcos sulforaphan sfn receiv great deal attent potent antioxid abil induc express antioxid enzym nuclear factor erythroid deriv like nrf signal pathway therefor present studi done investig protect effect sfn os granulosa lutein cell glcs patient pcos activ amp activ protein kinas ampk aktnrf signal pathway glcs isol patient pcos healthi fertil women control group egg retriev procedur level intracellular ros apoptosi determin isol cell investig protect effect sfn ros product apoptosi glcs cell cultur h presenc absenc sfn final express ampk akt nrf protein gene evalu western blot quantit real time polymeras chain reaction qrt pcr respect result indic increas ros apoptosi level glcs isol patient pcos compar control group addit sfn cultur medium glcs patient pcos reduc intracellular ros apoptosi level increas express ampk akt nrf protein gene find demonstr protect effect sfn os lower level ros apoptosi possibl activ ampk akt nrf protein gene express | D011085 | T047 |
34,678,577 | covid vaccin india ethic perspect covid put world standstil enorm morbid mortal vaccin develop provid beacon hope india approv differ vaccin emerg use author distribut vaccin vaccin huge popul challeng task attempt review vaccin program ethic perspect | D000086663;D028662 | T200;T078 |
34,678,576 | effect saffron supplement liver enzym systemat review meta analysi random control trial possibl protect effect saffron crocus sativus l report sever random clinic trial rcts current systemat review perform summar efficaci saffron intak liver enzym | D027622;D019587 | T168;T002;T061 |
34,678,575 | decreas hospit cardiac arrest ohca outcom metric persist known covid patient exclud analysi declin ohca perform metric pandem report literatur caus still known montgomeri counti fire rescu servic mcfrs observ declin rate return spontan circul rosc proport resuscit result cerebr perform categori cpc discharg patient begin march studi examin whether declin perform metric persist known covid posit patient exclud analysi | D019985 | T081 |
34,678,574 | efficaci safeti tolvaptan acut heart failur patient long distanc transport treat patient acut heart failur difficult local hospit medic depopul area cardiologist general absent patient requir long distanc time consum transport intens care unit well known tolvaptan effect treatment congest heart failur effect prehospit tolvaptan use patient well evalu aim studi evalu efficaci safeti prehospit tolvaptan use patient acut congest heart failur requir long distanc time consum transport | D014187 | T058 |
34,678,571 | prognost predict impact low estrogen receptor express earli breast cancer systemat review meta analysi tradit estrogen receptor er posit breast cancer defin tumor posit er updat american societi clinic oncologycolleg american pathologist ascocap guidelin recommend tumor er express classifi er low posit recogn limit clinic evid prognost predict role low er express aim investig predict role er low express neoadjuv chemotherapi neoct prognost signific er low express breast tumor compar er posit er negat breast tumor | D001943;D011960 | T192;T191;T116 |
34,678,569 | ara adversari robust train autoencod improv novelti detect autoencod recent wide employ approach novelti detect problem train normal data ae expect reconstruct normal data effect fail regener anomal data base assumpt one could util ae novelti detect howev known assumpt alway hold ae often perfect reconstruct anomal data due model low level generic featur input propos novel train algorithm ae facilit learn semant meaning featur address problem purpos exploit fact adversari robust promot learn signific featur therefor forc ae learn featur make bottleneck layer stabl adversari perturb idea general appli autoencod base approach well show despit use much simpler architectur prior method propos ae outperform competit state art four benchmark dataset two medic dataset | D000465;D019985 | T170;T081 |
34,678,567 | hip groin function strength male ice hockey player without hip groin problem previous season prospect cohort studi describ compar hip groin strength function male ice hockey player one season player without hip groin problem previous season | D006688;D053580 | T046;T042;T056 |
34,678,564 | photoelectrochem aptasensor sensit detect tetracyclin soil base cdte biobr heterojunct improv photoact enabl z scheme electron transfer pathway explor effect method tetracyclin tc detect soil great signific emerg environment problem increas threat soil qualiti general public health worldwid work sensit photoelectrochem pec aptasensor toward tc detect design construct base effici photosensit materi z scheme cdte biobr heterojunct due sensit cdte quantum dot qds biobr nanoflow photocurr intens cdte biobr heterojunct enhanc fold fold pure biobr cdte visibl light irradi attribut low electron hole combin effici high visibl light util effici high carrier densiti heterojunct merit excel pec activ cdte biobr specif aptam propos pec aptasensor advantag satisfi linear rang pm low detect limit pm good select reproduc addit accept accuraci obtain tc detect real soil sampl give accept accuraci comparison referenc high perform liquid chromatographi diod array detector method reveal promis avenu accur ultrasensit estim kind contamin broad field analysi | D052157;D015374;D019187;D045663 | T073;T114;T197;T075;T059 |
34,678,563 | har arbuscular mycorrhiz fungus improv adapt facult metallophyt poplar populus yunnanensi cadmium stress physiolog molecular respons populus yunnanensi dode facult metallophyt poplar exhibit afforest potenti barren mine tail area howev interact function role arbuscular mycorrhiz fungus amf p yunnanensi adapt heavi metal stress remain unclear physiolog molecular respons p yunnanensi plantlet amf funneliformi mossea cadmium cd stress mg kg investig result show attenu cd phytotox effect cell organell upon amf inocul also reduc cd concentr poplar leav stem root cd stress amf block metal transport eg ca channel activ occur decreas root cell cd influx reduc h efflux bioaugment rhizospher sediment amf stabil metal decreas dtpa extract cd also occur amf inocul promot cd convers inact less phytotox form help maintain ion homeostasi reliev nutrit ion eg ca mg disord caus excess cd leaf enzym non enzym antioxid system trigger root leaf physiolog respons pattern differ amf regul poplar function gene nine metal respons gene cluster identifi suggest amf function compon p yunnanensi phenotyp extens contribut strong adapt unfavor mine tail condit | D038821;D032107;D012989 | T131;T004;T002 |
34,678,561 | predict crop root concentr factor organ contamin machin learn model accur predict uptak accumul organ contamin crop soil essenti assess human exposur via food chain howev tradit empir mechanist model frequent show variabl perform due complex interact among contamin soil plant thus studi differ machin learn algorithm compar appli predict root concentr factor rcfs base dataset compris chemic crop follow comparison tradit linear regress model benchmark rcf pattern predict investig unsupervis distribut stochast neighbor embed four supervis machin learn model includ random forest gradient boost regress tree fulli connect neural network support vector regress base properti descriptor fulli connect neural network demonstr superior predict perform rcfs r mean absolut error mae machin learn model r mae four machin learn model perform better tradit linear regress model r mae four key properti descriptor identifi predict rcfs specif increas root lipid content decreas soil organ matter content increas rcfs increas excess molar refract molecular volum contamin decreas rcfs result show machin learn model improv predict accuraci learn nonlinear relationship rcfs properti contamin soil plant | D000069550;D012987 | T167;T066 |
34,678,560 | cell size matter nano micro plastic preferenti drive declin larg marin phytoplankton due co aggreg marin plastic pollut repres key environment concern whilst ecotoxicolog data plastic increas avail impact upon marin phytoplankton remain unclear owe predict abund marin environ like interact phytoplankton focus smaller fraction plastic particl nm polystyren sphere exposur natur phytoplankton communiti laboratori cultur reveal plastic exposur follow tradit trend ecotoxicolog research sinc larg phytoplankton appear particular suscept toward plastic exposur despit lower surfac volum ratio cell declin appear driven hetero aggreg co sediment cell plastic particl record visual demonstr use confoc microscopi consequ plastic exposur also caus disrupt photosynthet function determin photosynthet effici high throughput proteom negat effect upon phytoplankton record concentr order magnitud estim environ henc like impact nps mps exacerb high concentr typic use ecotoxicolog research ie mg l | D010969;D014874 | T167;T131 |
34,678,559 | good good role honesti integr health psycholog trait charact strength alreadi establish experiment studi factor play favor role well potenti reduc risk depress posit associ also report charact strength physic fit self report physic mental health yet evid larg scale epidemiolog data role charact strength honesti integr cshi shape subsequ health outcom daili function remain unexplor examin whether charact strength honesti integr prospect associ six physic health outcom two depress outcom two daili function outcom use data health retir studi obtain sampl older adult found year follow period compar individu score lowest cshi particip score third tertil lower risk lung diseas rr ci lower risk depress rr ci also report lower limit mobil ci less difficulti instrument activ daili live ci associ independ demograph prior socioeconom status psycholog factor health condit health behavior polici maker practition may consid charact strength honesti integr factor promot healthi longev limit risk becom physic inact reduc risk physic mental diseas | D000203;D006304 | T080;T056 |
34,678,558 | infant feed post wean health evid turn centuri london evid post wean benefit earli life breastfeed mix high context depend moreov evid drawn almost exclus modern set limit understand relationship breastfeed subsequ health past provid novel evid natur reach post wean benefit histor set draw rich new longitudin dataset cover near children foundl hospit orphanag turn centuri london find even cessat breastfeed ever breastf status reduc mortal risk rais weight age infanc exclus breastfeed confer addit benefit breastfeed durat littl impact also find u shape pattern weight age time sinc wean indic deterior health short wean follow recoveri earli post wean advantag associ breastfeed howev persist mid childhood indic protect effect earlier breastfeed attenu age suggest strong role catch growth studi contribut data empir set avail explor relationship infant feed post wean health help shed light contribut chang breastfeed norm trend health twentieth centuri britain | D001942 | T040;T058;T055 |
34,678,557 | identif novel impur ziprasidon ziprasidon hydrochlorid second generat antipsychot drug employ treatment schizophrenia acut mania mix episod associ bipolar disord scale ziprasidon hydrochlorid unknown impur observ batch rang hplc uv analysi structur unknown impur propos methylenebi benzo isothiazol yl piperazin yl ethyl chloroindolin one name methylen ziprasidon dimer mzd impur isol enrich sampl prepar hplc structur elucid comprehens analysi hrms nmr h c dept nmr cosi hsqc hmbc spectroscopi plausibl mechan format isol impur propos | D004340;D010879 | T068;T109 |
34,678,556 | analyt lifecycl manag alm analyt qualiti design aqbd analyt procedur develop relat substanc tenofovir alafenamid fumar tablet analyt procedur develop quantifi impur tenofovir alafenamid fumar taf tablet challeng analyt formul research aim paper develop robust regulatori flexibl applic specif ultra perform liquid chromatographi uplc analyt procedur use analyt lifecycl manag alm analyt qualiti design aqbd estim taf tablet work analyt target profil atp analyt procedur critic analyt attribut caa identifi risk assess studi high risk analyt condit found screen optim design experi doe obtain design space ds identifi work point predict interv use examin robust analyt procedur procedur perform qualif continu procedur perform verif use ensur routin applic analyt procedur final impur separ within min uplc success studi demonstr use use alm aqbd analyt procedur develop provid refer analyt procedur develop drug | D019380;D015658 | T047;T121 |
34,678,551 | longitudin effect covid relat loneli symptom mental distress among older adult austria covid relat social restrict result loneli whether effect mental health remain unclear studi aim examin longitudin effect covid relat loneli mental health among older adult age year austria | D000086382;D008132 | T033;T047;T067 |
34,678,549 | effect integr collis warn system risk compens behavior examin naturalist drive condit collis warn system improv traffic safeti safeti benefit may lessen due improp risk compens system misus limit studi advanc safeti system increas unexpect riski drive behavior especi adolesc driver studi design address research gap two main area seek examin whether introduct advanc driver assist system influenc driver risk compens behavior eg increas hard brake frequenc investig key factor eg distract contribut chang hard brake frequenc drive teen adult driver naturalist drive data two previous studi analyz studi two method hierarch logist regress model use evalu effect integr collis warn system hard brake behavior random forest algorithm appli model hard brake behavior rank contribut factor calcul import score statist evid observ integr collis warn system signific chang likelihood hard brake teen adult driver factor like distract especi visual manual distract largest impact hard brake behavior follow speed roadway segment ie intersect short time headway drive high densiti traffic signific increas likelihood hard brake furthermor rate hard brake behavior surfac road much higher highway expect compar straight road segment hard brake behavior less like occur curv road studi appli analyt strategi use machin learn statist analysi method achiev high model accuraci facilit infer concern relationship among variabl find studi help improv design integr collis warn system use autonom brake system appli appropri analysi method understand teen driver behavior chang safeti system | D000063;D001334 | T056;T037;T067 |
34,678,548 | causat analysi govern strategi hazard cargo accid port case studi tianjin port hazard cargo explos accid import part global ship industri hazard cargo transport port concern countri around world due great hazard high risk oper howev multipl hazard cargo accid occur port recent year explos accid hazard cargo tianjin port china typic case topic worth depth studi figur analyz causat factor accid propos effect govern strategi articl take hazard cargo explos tianjin port china subject systemat analyz causat factor accid base fault tree analysi fta method propos strategi govern hazard cargo port analysi result show hazard cargo explos port complic causat factor among manag human factor play predomin role overal accid causat structur factor includ environment factor cargo facil factor final correspond safeti govern strategi propos base structur relationship various accid causat factor analysi studi offer guidanc port enterpris reduc hazard cargo accid port provid import basi port author formul strategi emerg manag emerg decis make hazard cargo accid port | D005107;D015386 | T131;T067 |
34,678,547 | classif identif differ miner mediterranean sediment use psa ftir xrd techniqu mediterranean coastal region nile delta critic socioeconom signific environment stress due grow load divers land base activ studi examin fluctuat concentr sever miner sediment depth rang studi consid first work carri identif differ miner use two differ techniqu fourier transform infrar spectroscopi ftir x ray diffract techniqu xrd area time particl size also assess particl size analyz psa result show grain size analys sediment vari slight gravelli sand slight gravelli mud silti sand miner identif use ftir xrd analysi prove miner aragonit calcit quartz kaolinit montmorillonit albit muscovit microclin present studi locat | D002119;D008903 | T121;T197 |
34,678,546 | coastal coral heat stress eutroph case studi northwest hainan coastal area studi initi investig coral status unexpect bleach event three coastal area northwest hainan coastal area analyz chang coral holobiont healthi bleach galaxea fasciculari coral coverag declin sever bleach rate extrem high heat stress bleach coral lower maximum photosynthet yield actual photosynthet yield zooxanthella densiti chlorophyl content healthi g fasciculari signific differ protein carbohydr lipid eutroph water divers communiti composit symbiodiniacea symbiot bacteria healthi bleach g fasciculari show differ function predict symbiot bacteria reveal metabol process main pathway annot present find suggest energi reserv function high stabil holobiont structur might provid opportun g fasciculari adapt eutroph heat stress | D037421;D004141 | T204 |
34,678,545 | organochlorin pesticid ocp polychlorin biphenyl pcbs occurr sparus aurata expos microplast enrich diet aquacultur facil organochlorin pesticid ocp polychlorin biphenyl pcbs high stabl bioaccumul microplast mps plastic mm ubiquit marin environ studi report level select pollut liver muscl juvenil gilthead seabream sparus aurata expos virgin weather mp enrich diet three month follow one month mp depur general major concentr pollut liver observ accord ocp total ddts two three time higher liver level muscl suffer higher variabl treatment sampl period mp index negat correl hcb posit p pddt liver level pollut correl biolog paramet total size total weight result suggest bioaccumul subject molecular structur pollut mps correl detoxif system | D006843;D010575;D011078;D021541;D014874 | T131;T013;T109 |
34,678,544 | busi analysi irt visual observ ovsynch breed strategi alberta dairi dairi industri search new technolog address low er accuraci determin potenti financi benefit breed method repres farm breed cost result canadian dollar per cow cadcow show higher cost ov compar vo irt pregnanc cost affect breed cost howev er signific effect pr expens method irt er vo er ov er minimum se level posit financi effect irt vo sp ov se sp howev se posit financi effect observ minimum sp irt vo cull risk reduc er increas differ depend pariti group implement irt estrus detect method yield competit breed cost compar vo ov breed method must accomplish least accuraci posit net return | D004973;D007315 | T061;T067 |
34,678,543 | develop total suspend matter predict water use fraction order deriv spectra hyper spectral satellit use estim total suspend matter tsm water instead multi spectral satellit china gaofen zhuhai although wide use consist sampl imag time henc studi base measur hyper spectroscopi import appli hyper spectral satellit fraction order deriv fod consid detail spectral inform better spectral preprocess method convent integ order deriv applic analysi fod spectra water rare fod success appli estim tsm tsm map fod use hyper spectral satellit meaning base point studi aim appli fod predict tsm prove predict feasibl fod water differ predict model eight fod transform process increment per step spectral reflect data china use compar predict model includ optimum model singl wavelength ratio index differ index tsm index fod order random forest rf model wavelength also use discret wavelet transform dwt use reduc nois improv model accuraci use fod result achiev follow first fod enhanc spectral characterist nm nm affect tsm second correl tsm fod spectra enhanc eg correl coeffici wavelength nm order higher origin spectra third fod improv perform differ predict model rf model order order deriv spectra led good result fourth dwt reduc nois improv perform fod dwt model order led r rmse mape valid overal result suggest fod improv predict perform model optimum order model integ result also provid refer predict water qualiti paramet map paramet use hyper spectral satellit accur estim tsm help protect ecolog social environ | D004784;D058067 | T062;T057 |
34,678,542 | disentangl driver phytoplankton communiti composit heavili sediment laden transcontinent river phytoplankton play crucial role energi flow carbon cycl aquat ecosystem howev explor drive factor influenc phytoplankton especi heavili sediment laden river challeng analyz sampl sampl site along yellow river investig biogeograph environment anthropogen impact phytoplankton communiti composit use cluster analysi identifi three differ phytoplankton communiti composit region consist three primari chang water surfac slope across three region sampl result show bacillariophyta primarili consist navicula cyclotella synedra fragilaria gyrosigma diatoma asterionella addit represent chlorophyta domin chlamydomona pandorina closteriopsi closterium phormidium domin cyanophyta genus variat partit result indic spatial factor geograph distanc import determin phytoplankton communiti success addit result highlight influenc spatial climat factor success phytoplankton communiti structur much greater water qualiti compar free flow river phytoplankton biomass impound much higher phytoplankton communiti domin dinophyta chlorophyta cyanophyta primarili anthropogen impact base composit biomass phytoplankton communiti differ region phytoplankton communiti composit yellow river found primarili influenc eros watersh inflow tributari rather limit situ alga growth | D017377;D010839 | T204;T002 |
34,678,541 | dual phase statist optim biolog pre treatment sugarcan bagass pycnoporus coccineus mscms polyhydroxyalkano product biolog pre treatment remov recalcitr lignin lignocellulos action lignin degrad organ andor ligninolyt enzym system despit numer environment benefit biolog pre treatment side line due prolong period ferment ascrib slow growth rate lignin degrad organ thus present work adopt dual phase statist optim approach biolog pre treatment sugarcan bagass pycnoporus coccineus mscms use taguchi orthogon array conjunct respons surfac methodolog address issu amplif organ function result enhanc sugar product yield accompani signific reduct ferment time optim sugar concentr approx gl within day pre treatment product g lday substrat composit analysi reveal signific p reduct lignin biolog pre treat substrat along signific p higher quantiti water solubl compon g cellulos content g compar untreat substrat appreci level xylos arabinos glucos galactos detect hydrolys biolog pre treat bagass furthermor bacillus megaterium ti potent polyhydroxyalkano pha produc grown sugar rich hydrolys generat gl pha h ferment accompani gl dri cell weight pha accumul result compar glucos medium thus present studi success optim biolog pre treatment sugarcan bagass util result sugar rich hydrolys inexpens renew raw materi pha product | D054813;D031786 | T002;T109 |
34,678,540 | ensembl system short term carbon dioxid emiss forecast base multi object tangent search algorithm carbon emiss play crucial role induc global warm climat chang accur stabl carbon emiss forecast benefici formul emiss reduct scheme achiev carbon neutral earli possibl although previous studi concentr employ one sever method carbon emiss forecast improv forecast perform limit ignor import object select model necess interv forecast paper novel ensembl predict system compos data decomposit model select phase space reconstruct ensembl point predict interv predict propos conduct point interv predict proven effect prompt carbon emiss forecast accuraci stabil accord empir result mean mape result propos forecast strategi point predict dataset dataset b mean cwc valu interv forecast respect thus propos forecast system improv forecast perform relat model consider provid meaning refer policymak | D000465;D002245 | T170;T197;T123 |
34,678,539 | applic coke breez remov colour coke plant wastewat treatment coke wast water alway challeng complex toxic natur number technolog like biolog treatment advanc oxid process activ carbon treatment etc avail remov color organ contamin wastewat howev challeng problem associ applic biolog advanc oxid method remov color chemic oxygen demand cod cyanid led thrust develop new promis technolog studi applic coke breez treatment wastewat adsorpt demonstr pseudo second order reaction kinet observ batch process adsorpt studi furthermor adsorpt data found best fit freundlich adsorpt isotherm model color remov effici along cod remov effici observ within min gl dosag adsorb remov phenol organ compound coke wastewat measur uv vis spectroscopi morpholog chang adsorb coke breez captur scan electron microscopi sem energi dispers x ray edx analysi howev signific abund steel plant cost effect applic post treat coke breez sinter plant fuel turn suitabl adsorb despit much lower specif surfac area compar commerci activ carbon ac therefor applic coke breez turn promis materi techniqu sustain toward coke quench effluent treatment | D003077;D014874 | T167;T131 |
34,678,538 | futur climat impact forest growth implic carbon sequestr reforest southeast australia reforest identifi one key natur base solut deliv carbon dioxid remov requir achiev net zero ambit pari agreement howev potenti sequestr reforest uncertain climat chang expect affect driver forest growth studi use process base pg model investig effect climat chang develop ground biomass agb indic forest growth regener nativ forest southeast australia investig chang climat affect agb combin histor data futur climat project base global climat model gcms coupl model intercomparison project phase cmip two share socioeconom pathway found ensembl mean gcms indic increas temperatur larg variat project rainfal chang appli pg found increas simul agb much moder emiss scenario estim rose high emiss scenario end st centuri across nine select site southeast australia howev co respons exclud found larg decreas agb nine site model result show model respons elev atmospher co co fertil effect larg respons simul increas agb found estim futur chang agb subject uncertainti origin climat project futur emiss scenario assum respons co fertil model simul improv understand possibl climat chang impact forest growth inher uncertainti estim mitig potenti reforest implic climat polici australia | D057965;D000090082 | T062;T170;T066;T067 |
34,678,537 | unpreced biodesalin rate shortcom electr conduct measur determin salt remov alga cyanobacteria phormidium keutzingianum perform biodesalin brackish water gl electr conduct ec measur evalu salt concentr day cyanobacteri inocul anion concentr measur use ion chromatographi estim salt remov ec base measur show remov effici first day howev remov effici base chlorid ion concentr show remov time frame ph increas observ growth algal biomass increas ph propos format hydroxyl carbon ion sulfur acid ad day neutral ph ec reduc signific confirm chlorid remov ec use measur salt reduct obscur paramet therefor ec best choic measur salin remov use alga recent publish studi use ec estim biodesalin anticip salt remov misrepres studi | D000458 | T007 |
34,678,529 | deep attent branch network skin lesion classif skin lesion usual cover small region dermoscopi imag lesion differ categori might high similar therefor essenti design elabor network accur skin lesion classif focus semant meaning lesion part although class activ map cam show good local capabl highlight discrimin part obtain forward propag process | D012871;D012878 | T191;T047 |
34,678,528 | syringa microphylla diel comprehens review phytochem pharmacolog pharmacokinet toxicolog characterist investig potenti health benefit syringa microphylla diel plant famili syringa linn hundr year flower leav use folk medicin treatment cough inflamm cold sore throat acut hepat chronic hepat earli liver cirrhosi fatti liver oesophag cancer | D031662 | T002 |
34,678,527 | comparison clinic outcom use activ partial thromboplastin time versus antifactor xa monitor therapeut unfraction heparin systemat review meta analysi continu intraven unfraction heparin ufh mainstay therapeut anticoagul acut set two common laboratori test monitor ufh activ partial thromboplastin time aptt antifactor xa anti xa heparin assay review avail evid evalu choic monitor test ufh therapi associ differ clinic outcom bleed thrombosi mortal | D006493 | T121;T109;T123 |
34,678,526 | resid led initi advanc divers equiti inclus antirac pediatr resid program racial ethnic divers physician workforc critic meet need unit state increas divers patient popul unfortun black latinx american indian alaska nativ communiti remain underrepres medicin disproportion impact covid pandem raceethn increas public attent anti black anti asian racism inspir grow nation discours address system racism within academ medicin call fundament incorpor antirac medic train profession compet perspect group primarili led resid women color describ year experi lead divers committe catalyz sustain system effort advanc divers equiti inclus dei antirac larg urban pediatr resid program outlin implement key outcom divers committe ongo initi increas resid divers foster inclus learn environ develop resid curriculum dei antirac center need wisdom communiti institut serv final highlight challeng lesson learn inform institut strive advanc dei antirac academ medicin | D000086382;D007396;D010372 | T065;T047;T097;T091;T067 |
34,678,521 | risk vulvar squamous cell carcinoma lichen sclerosus lichen planus systemat review object studi determin preval lichen sclerosus ls lichen planus lp present associ vulvar squamous cell carcinoma vscc incid absolut risk develop vscc ls lp | D002294;D008010;D018459;D014846 | T191;T047 |
34,678,519 | chang landscap radiat therapi advanc cervic cancer focus interstiti brachytherapi canadian practic pattern survey document evolut radic radiat therapi interstiti brachytherapi isbt util practic pattern across canada includ use imag technic detail usag anesthesiaanalgesia compar advanc ac versus nonadvanc nac brachytherapi bt center practic | D001918;D002583 | T191;T061 |
34,678,518 | versatil multiplex mass spectrometri base absolut quantif cell free synthes intern standard peptid prepar stabl isotop label intern standard peptid crucial mass spectrometri ms base target proteom herein develop versatil multiplex absolut protein quantif method use ms previous develop method base cell free peptid synthesi system term ms base quantif isotop label cell free product ms qbic improv multipl peptid synthesi one pot reaction plural quantif tag use quantif synthes peptid thus made possibl use cell free synthes isotop label peptid mixtur absolut quantif improv multiplex ms qbic method prove appli clarifi ribosom protein stoichiometri ribosom subunit one largest cellular complex studi demonstr develop method enabl prepar sever dozen even sever hundr intern standard peptid within day quantif multipl protein singl run ms analysi signific develop method appli prepar intern standard peptid without limit number peptid synthes may result practic screen quantit reliabl peptid one fundament step reliabl absolut quantif use ms furthermor method high versatil proteom analysi organ speci without cdna sil peptid librari quantif finish day includ design prepar appropri sil peptid use small scale batch cell free reaction potenti part standard methodolog field quantit proteom | D010455;D040901 | T091;T116;T121 |
34,678,517 | comparison extracellular matrix enrich protocol improv character skin matrisom mass spectrometri strike featur skin organ extracellular matrix ecm occupi larger volum cell skin ecm also direct contribut age cutan diseas recent year specif ecm enrich protocol combin silico approach allow proteom descript matrisom various organ tumor sampl nevertheless skin matrisom remain studi protocol allow effici recoveri divers ecm found skin still describ compar four protocol allow enrich ecm protein adult mous back skin found protocol led signific enrich matrisom protein compar total skin lysat protocol base decellular solubl profil gave best result term number protein identifi confirm skin matrisom protein exhibit divers solubl abund profil also report first descript skin matrisom healthi adult mice includ protein compris core matrisom protein associ matrisom protein result provid reliabl basi futur character skin ecm protein dysregul diseas specif context signific extracellular matrix protein key player skin physiopatholog involv sever diseas genet disord wound heal defect scleroderma skin carcinoma howev skin ecm protein numer divers challeng analyz mass spectrometri due multipl post translat modif heterogen solubl profil perform thorough evalu four ecm enrich protocol compat proteom analysi mous back skin provid first descript adult mous skin matrisom homeostasi condit work great facilit futur character skin ecm alter preclin mous model inspir new optim analyz skin matrisom speci human clinic sampl | D005109;D040901 | T091;T024 |
34,678,515 | european societi clinic microbiolog infecti diseas updat treatment guidanc document clostridioid difficil infect adult european societi clinic microbiolog infecti diseas escmid publish first treatment guidanc document clostridioid difficil infect cdi document updat grow literatur cdi antimicrobi treatment novel treatment approach faecal microbiota transplant fmt toxin bind monoclon antibodi prompt escmid studi group c difficil esgcd updat treatment guidanc document cdi adult | D000900;D003015;D017410 | T047;T121;T170;T195;T037;T078 |
34,678,513 | bone marrow mesenchym stem cell deriv exosom mir c p amelior rif inhibit core fucosyl multipl protein renal interstiti fibrosi rif incur patholog lesion chronic kidney diseas pericyt activ major patholog characterist rif fibroblast macrophag activ also involv rif studi reveal core fucosyl cf import post translat modif protein play key role pericyt activ rif regul multipl profibrot signal pathway hub like target reveal mesenchym stem cell msc deriv exosom resid specif injur kidney deliv microrna mir c p reduc cellular activ rif inhibit cf furthermor show cd epiderm growth factor receptor egfr ligand receptor complex aid entri exosom mir c p pericyt fibroblast macrophag altogeth find reveal novel role msc deriv exosom inhibit multicellular activ via cf provid potenti intervent strategi renal fibrosi | D055354;D007674;D059630;D035683 | T047;T123;T026;T025;T114 |
34,678,512 | il integr car exodomain convert cd cell poli function nk like cell superior kill antigen loss tumor chimer antigen receptor car redirect cell therapi often fail control tumor long term due select cancer cell downregul lost car target antigen reprogram function capac specif engin car cell insert il extracellular moieti cd car car endodomain il function activ indic antigen redirect effector function stat phosphoryl respect il car reprogram cd cell toward far recogn natur killer nk cell like signatur cd cd cdl high phenotyp close similar ident nk cytokin induc killer cik cell contrast convent car cell il car cell acquir antigen independ human leukocyt antigen e hla e restrict cytotox capac elimin antigen negat cancer cell addit elimin cancer cell car cognat antigen simultan signal car endodomain il requir induc maxim nk like cytotox ad il convent car cell suffici antigen negat tumor attack il car cell convent car cell overal present prototyp new famili car augment tumor recognit elimin expand function capac appropri cytokin integr car exodomain | D018414;D016219;D018664;D009369 | T116;T191;T121;T025;T129;T061 |
34,678,511 | crispr activ endogen gene reprogram fibroblast cardiovascular progenitor cell myocardi infarct therapi fibroblast reprogram cardiovascular progenitor cell cpcs use transgen approach although under mechan remain unclear determin whether activ endogen gene gata nkx tbx rapid establish autoregulatori loop initi cpc generat adult extracardiac fibroblast use crispr activ system induc fibroblast show phenotyp chang indic nkx cardiac enhanc report progenitor characterist confirm coloni format express cardiovascular gene cardiac sphere induct segreg earli late reprogram cell generat function cardiomyocyt vascular cell vitro therefor term crispr induc cpcs cicpc transcriptom analysi show cell cycl heart develop pathway import acceler cpc format earli reprogram stage crispr system open silenc chromatin locus therebi allow transcript factor access promot eventu form posit feedback loop regen potenti cicpc assess implant mous myocardi infarct model engraft cicpc differenti cardiovascular cell vivo also signific improv contractil function scar format conclus multiplex gene activ suffici drive cpc reprogram provid new cell sourc regen therapeut | D064112;D009203 | T028;T047;T114 |
34,678,510 | kidney singl cell transcriptom profil reveal distinct respons proxim tubul cell sglti arb treatment diabet mice angiotensin receptor blocker arb sodium glucos cotransport inhibitor sglti use standard therapi patient diabet kidney diseas dkd howev two drug possess addit renoprotect effect remain unclear conduct singl cell rna sequenc profil kidney cell transcriptom dbdb mice treat vehicl arb sglti arb plus sglti use dbm mice control identifi distinct cluster kidney cell predomin proxim tubular pt cell found arb anti inflammatori anti fibrot effect sglti affect mitochondri function pt also identifi new pt subclust increas dkd revers treatment new subclust also confirm immunostain mous human kidney dkd togeth studi reveal kidney cell specif gene signatur respons arb sglti identifi new pt subclust provid new insight pathogenesi dkd | D003921;D003928 | T047;T050 |
34,678,508 | effect albumin bound nitrosyl iron complex thiosulf ligand lipid peroxid activ mitochondri enzym vitro nitric oxid mediat divers physiolog process live organ small molecular donor usual lack stabil short half life human tissu limit therapeut applic anion tetranitrosyl iron complex thiosulf ligand tnic one promis donor studi show bovin serum albumin bsa effect stabil tnic complex aerob physiolog condit contribut prolong action donor result demonstr tnic bsa inhibit format tbar standard biomark lipid peroxid induc oxid stress also found tnic bsa inhibit catalyt activ mitochondri membran bound enzym cytochrom c oxidas monoamin oxidas togeth result demonstr stabil tnic bsa open possibl practic applic chemotherapi social signific diseas | D007501;D008928;D009589;D012710;D013885 | T116;T121;T123;T043;T026;T130;T196;T197 |
34,678,507 | gmez lpez hernndez syndrom case report pediatr neurotroph corneal ulcer review literatur present case gmez lpez hernndez syndrom glhs rare neurocutan syndrom month old girl neurotroph keratopathi secondari trigemin anesthesia | D000015;D003320;D019465;D020752 | T047;T019 |
34,678,505 | geospati variabl excess death rate covid pandem mexico examin socio demograph climat popul health characterist studi examin socio demograph climat popul health characterist shape geospati variabl excess mortal pattern covid pandem mexico | D000086382;D000075485 | T058;T047;T067 |
34,678,504 | evalu panbio rapid antigen test sar cov symptomat patient contact multicent studi point care rapid test identifi sar cov clinic benefit | D000086382;D000086402 | T047;T005;T067 |
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