anchor_id stringlengths 8 8 | anchor_title stringlengths 5 839 | anchor_abstract stringlengths 2 61.6k | positive_pool listlengths 1 1 | negative_pool listlengths 1 1 |
|---|---|---|---|---|
28759998 | Pharmacist Participation in Acute Ischemic Stroke Decreases Door-to-Needle Time to Recombinant Tissue Plasminogen Activator. | Pharmacists are an important member of the stroke team and aid in obtaining medication and medical history, providing education, managing blood pressure, reviewing exclusion criteria for recombinant tissue plasminogen activator (rtPA), and facilitating reconstitution and administration of rtPA.</AbstractText To determi... | [
[
"27110714",
"Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors.",
"Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that... | [
[
"28285191",
"Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS/NF-κB signaling via downregulation of HNF1b.",
"Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, w... |
35993408 | A Novel Dynamin 2 Mutation Causing Dominant Intermediate Charcot-Marie-Tooth Neuropathy: Case Report. | Dynamin 2 mutations are associated with Charcot-Marie-Tooth neuropathy. We report two siblings with a novel missense heterozygous point mutation (c.1609 G>A) in the highly conserved pleckstrin homology domain in exon 15 of Dynamin 2 presenting with progressive length-dependent sensorimotor polyneuropathy with mixed ... | [
[
"31069783",
"A novel WARS mutation (p.Asp314Gly) identified in a Chinese distal hereditary motor neuropathy family.",
"Distal hereditary motor neuropathy (dHMN) is a clinically and genetically heterogeneous group of inherited neuropathies characterized by distal limb muscle wasting and weakness with n... | [
[
"34686764",
"Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.",
"Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differe... |
40269690 | Prediction model and scoring system for the risk of atrial fibrillation recurrence in patients with atrial fibrillation and obstructive sleep apnoea syndrome: a retrospective case-control study. | The high prevalence of atrial fibrillation (AF) and obstructive sleep apnea syndrome (OSAS) imposes a substantial disease burden on public healthcare, making it a significant health concern in the current era. However, there is currently a lack of risk assessment tools for AF recurrence in patients with AF and OSAS. Th... | [
[
"20725915",
"Blood oxygenation level-dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease.",
"To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures o... | [
[
"40515391",
"Gene Swin transformer: new deep learning method for colorectal cancer prognosis using transcriptomic data.",
"Transcriptome sequencing has become essential in clinical tumor research, providing in-depth insights into the biology and functionality of tumor cells. However, the vast amount o... |
22890939 | SNR-optimized phase-sensitive dual-acquisition turbo spin echo imaging: a fast alternative to FLAIR. | Phase-sensitive dual-acquisition single-slab three-dimensional turbo spin echo imaging was recently introduced, producing high-resolution isotropic cerebrospinal fluid attenuated brain images without long inversion recovery preparation. Despite the advantages, the weighted-averaging-based technique suffers from noise a... | [
[
"16155898",
"New insights into the mechanisms of signal formation in RF-spoiled gradient echo sequences.",
"RF spoiling is a well established method to produce T(1)-weighted images with short repetition-time gradient-echo sequences, by eliminating coherent transverse magnetization with appropriate RF ... | [
[
"23992544",
"Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.",
"G-protein coupled receptor (GPR)55 is a novel lipid sensing receptor activated by both cannabinoid endogenous ligands (endocannabi... |
40772448 | Wishes, conflicts, and support needs of informal caregivers of patients in the palliative phase: A qualitative study. | This study explored wishes, conflicts, beneficial, and wished support of informal caregivers (ICGs) providing care to a palliative ill close other. We interviewed five current and 15 bereaved ICGs (25-75 years), and used thematic analyses. ICGs wished to continue life as normal as possible, spend time together a... | [
[
"38845595",
"Staying in control: Characterizing the mechanisms underlying cognitive control in high and low arousal states.",
"Throughout the day, humans show natural fluctuations in arousal that impact cognitive function. To study the behavioural dynamics of cognitive control during high and low arou... | [
[
"40132153",
"Neuroimaging in Children With Inherited Metabolic Epilepsies.",
"Inherited metabolic epilepsies (IMEs) represent inherited metabolic disorders in which seizures, various in types and typically intractable, are one of the predominant manifestations and primary determinants of the overall o... |
40492610 | MDMA-assisted psychotherapy for AUD: Bayesian analysis of WHO drinking risk level and exploratory analysis of drinking behavior and psychosocial functioning at 3 months follow-up. | Safety and tolerability data from the first open-label feasibility study of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for alcohol use disorder was recently published. This paper presents a Bayesian analysis of the impact of MDMA-assisted psychotherapy on treatment success, defined as 2-level reduc... | [
[
"38619933",
"Suggesting a holistic framework for understanding healthcare services leadership competence - a critical interpretive synthesis.",
"Healthcare providers are under pressure due to increasing and more complex demands for services. Increased pressure on budgets and human resources adds to an... | [
[
"39955842",
"Hormones, brain and behavior in birds: The Lehrman legacy.",
"This short essay is based on the presentation I gave at the meeting of the Society of Behavioral Neuroendocrinology held in Tours, France in June 2023 when I received the Lehrman award for career achievement. I conducted my PhD... |
38412004 | Characteristics of Hepatitis B Virus, Hepatitis C Virus, and Syphilis Coinfection in People With HIV/AIDS Contracted Through Different Sources: Retrospective Study. | The burden of hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis coinfections remains disproportionately high among people living with HIV/AIDS. Hubei province is located in central China, where there are distinct regional characteristics of the distribution of people living with HIV/AIDS acquired via diver... | [
[
"37795953",
"Diagnostic value of cerebrospinal fluid chemokine c-x-c motif ligand 13 for neurosyphilis: A systematic review and meta-analysis.",
"The diagnostic value of cerebrospinal fluid chemokine c-x-c motif ligand 13 (CSF CXCL13) for neurosyphilis was assessed by meta-analysis in this study. PubM... | [
[
"39391051",
"Deciphering Proteomic Expression in Inflammatory Disorders: A Mass Spectrometry Exploration Comparing Infectious, Noninfectious, and Traumatic Brain Injuries in Human Cerebrospinal Fluid.",
"The central nervous system (CNS) evokes a complex inflammatory response to injury. Inflammatory ca... |
40102551 | Hair cortisol as a marker of stress in mild traumatic brain injury: a challenging measure. | Cortisol is released through activation of the hypothalamic-pituitary-adrenal axis by physiological and psychological stressors, such as mild traumatic brain injury (mTBI). This hormone is accumulated in hair over longer periods of time, reflecting both acute and chronic forms of stress, allowing for retrospective anal... | [
[
"34054681",
"Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions.",
"We aimed to detect the possible accelerating role of previous traumatic brain injury (TBI) exposures on the onset of later cognitive decline assessed across different brain diseases. We analyze... | [
[
"39333695",
"Exploring the structure and dynamics of soft and hard cuticle of Bombyx mori using solid-state NMR techniques.",
"This study conducts a comprehensive analysis and comparison of Bombyx mori cuticles across different developmental stages, ranging from larval to adult, utilizing advanced sol... |
20883353 | Identification of red-green colour deficiency: sensitivity of the Ishihara and American Optical Company (Hard, Rand and Rittler) pseudo-isochromatic plates to identify slight anomalous trichromatism. | Screening sensitivity, based on a specific number of errors, of the Ishihara plates and of the American Optical Company (Hardy, Rand and Rittler) plates (HRR plates) was determined by reviewing data obtained for 486 male anomalous trichromats identified and classified with the Nagel anomaloscope. Data were obtained for... | [
[
"15252758",
"Signatures of selection and gene conversion associated with human color vision variation.",
"Trichromatic color vision in humans results from the combination of red, green, and blue photopigment opsins. Although color vision genes have been the targets of active molecular and psychophysic... | [
[
"20428887",
"The role of anterior insular cortex in social emotions.",
"Functional neuroimaging investigations in the fields of social neuroscience and neuroeconomics indicate that the anterior insular cortex (AI) is consistently involved in empathy, compassion, and interpersonal phenomena such as fai... |
28774650 | Rapid anatomical brain imaging using spiral acquisition and an expanded signal model. | We report the deployment of spiral acquisition for high-resolution structural imaging at 7T. Long spiral readouts are rendered manageable by an expanded signal model including static off-resonance and B<sub | [
[
"11810678",
"Elimination of Nyquist ghosting caused by read-out to phase-encode gradient cross-terms in EPI.",
"Echo-planar imaging (EPI) commonly suffers from ghosting artifacts caused by zero- or first-order phase differences between the odd and even echoes that constitute an EPI dataset. Small-bore... | [
[
"29872302",
"Valium without dependence? Individual GABA(A) receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects.",
"Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over ... |
24711394 | Homeostasis of functional maps in active dendrites emerges in the absence of individual channelostasis. | The maintenance of ion channel homeostasis, or channelostasis, is a complex puzzle in neurons with extensive dendritic arborization, encompassing a combinatorial diversity of proteins that encode these channels and their auxiliary subunits, their localization profiles, and associated signaling machinery. Despite this, ... | [
[
"12417672",
"Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task.",
"Decisions about the visual world can take time to form, especially when information is unreliable. We studied the neural correlate of gradual decision formation by recordin... | [
[
"23893323",
"An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder.",
"Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness o... |
40056182 | Review of 7T MRI imaging of pituitary microadenomas: are we there yet? | 7T MRI imaging of the pituitary gland is an emerging technique. The purpose of this article is to review the current status of the 7T MRI of the pituitary gland, particularly in the context of pituitary microadenoma pathology. We will discuss technical challenges and parallel transmission opportunities.</AbstractText F... | [
[
"19449383",
"A transmit/receive system for magnetic field monitoring of in vivo MRI.",
"Magnetic field monitoring with NMR probes has recently been introduced as a means of measuring the actual spatiotemporal magnetic field evolution during individual MR scans. Receive-only NMR probes as used thus far... | [
[
"40503482",
"Magnetic resonance defecography assessment of obstructed defecation syndrome in patients with chronic constipation in a tertiary care hospital.",
"Obstructed defecation syndrome (ODS) is a subtype of constipation that is considered one of the major pelvic floor dysfunctions affecting the ... |
40166768 | Crossing the chasm: engaging Black men survivors of gun violence in mental health services. | Despite being high risk for post-traumatic stress disorder, Black men survivors of gun violence, and particularly young men aged 18-24, seldom participate in mental health services after injury. The aim of this study was to identify barriers to participation in mental health services for this population.</AbstractText ... | [
[
"25863813",
"Cerebellar Contribution to Context Processing in Extinction Learning and Recall.",
"Whereas acquisition of new associations is considered largely independent of the context, context dependency is a hallmark of extinction of the learned associations. The hippocampus and the prefrontal cort... | [
[
"40412529",
"Surgical Nerve Decompression at Lower Extremity for Diabetic Neuropathy: A Systematic Review and Meta-Analysis of Time-Dependent Pain, Sensory Recovery, Amputation, Ulcer Recurrence, and Balance.",
"This systematic review and meta-analysis evaluated the efficacy of surgical nerve decompre... |
39570907 | Functional near-infrared spectrometry for auditory speech stimuli in cochlear implant users: a systematic literature review. | This study aims to identify the acquisition features of functional near-infrared spectroscopy (fNIRS) in cochlear implant users.</AbstractText A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, LILACS, Web of... | [
[
"25151264",
"Dimensionality reduction for large-scale neural recordings.",
"Most sensory, cognitive and motor functions depend on the interactions of many neurons. In recent years, there has been rapid development and increasing use of technologies for recording from large numbers of neurons, either s... | [
[
"38159612",
"Association Between Quality of Life and Neurogenic Bowel Symptoms by Bowel Management Program in Spina Bifida.",
"To compare differences in bowel-specific quality of life (QOL), overall qQOL, and neurogenic bowel dysfunction (NBD) severity by bowel management program in patients with spin... |
40715419 | Inter- and intra-bacterial strain diversity remains the "elephant in the (living) room". | Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen responsible for severe nosocomial infections worldwide. Resistance to last-resort antibiotics causes A. baumannii to be ranked as a top priority for the research and development of new antibiotics by the WHO and an urgent threat to public heal... | [
[
"33495315",
"Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.",
"Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations. PDAC CAFs are... | [
[
"40413347",
"Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.",
"Type 1 Diabetes Mellitus (T1DM) progression has a direct impact on brain microstructural integrity and typical functional organization from the early stages of neurodevelo... |
40461172 | Medical management of ADHD in adults: part 2. | Methylphenidate and lisdexamfetamine are recommended as first-line pharmacological treatment options for adults with attention deficit hyperactivity disorder (ADHD). Formulations of methylphenidate can generally be classified into three groups according to their duration of action: one group lasts 12 hours, another gro... | [
[
"39376970",
"Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study.",
"In previous observational studies and meta-analyses, childhood attention deficit hyperactivity disorder (ADHD) is found to have a significant association with scre... | [
[
"40737393",
"The β(2)-adrenergic receptor (Adrb2) entrains circadian gene oscillation and CD8(+) T cell differentiation in response to virus infection.",
"Adaptive immune cells are regulated by circadian rhythms both under steady state conditions and during responses to infection. Cytolytic CD8<sup"
... |
39853319 | Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis. | Behavioral addictions (BAs) represent complex and multifaceted disorders often associated with maladaptive neural alteration. To deepen our understanding of the essence of BAs, this study focuses on the neural mechanisms underlying its three stages: reward seeking, self-control, and decision-making. The aim of the curr... | [
[
"26802508",
"A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play.",
"Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with de... | [
[
"39804020",
"Step Width Haptic Feedback for Gait Stability in Spinocerebellar Ataxia: Preliminary Results.",
"Wider step width and lower step-to-step variability are linked to improved gait stability and reduced fall risk. It is unclear if patients with spinocerebellar ataxia (SCA) can learn to adjust... |
29471227 | The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study. | Abuse of methamphetamine (MA) is a global health concern. Previous <sup Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited. Two-dimensional chemical shift <sup Acute MAA showed lower n-acetyl-aspartate (NAA) and n-acetyl-aspartate with n-acetyl-aspartyl-g... | [
[
"24897622",
"μHigh resolution-magic-angle spinning NMR spectroscopy for metabolic phenotyping of Caenorhabditis elegans.",
"Analysis of model organisms, such as the submillimeter-size Caenorhabditis elegans, plays a central role in understanding biological functions across species and in characterizin... | [
[
"29905724",
"Energy density and energy flux in the focus of an optical vortex: reverse flux of light energy.",
"Using the Richards-Wolf formulas for an arbitrary circularly polarized optical vortex with an integer topological charge m, we obtain explicit expressions for all components of the electric ... |
40385881 | Post-thalamotomy Changes Mimicking Cavernous Malformations on MRI: A Case Report of a Historical Surgical Treatment. | The patient was a 65-year-old man with cervical dystonia onset at age six who had been treated at Chiba University Hospital. He was diagnosed and followed up with cavernous malformations and chronic cerebral infarctions based on an MRI. However, during the re-evaluation of MRI, lesions with low signal intensity (SI) co... | [
[
"21666131",
"Abnormal structure-function relationship in spasmodic dysphonia.",
"Spasmodic dysphonia (SD) is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. Although recent studies have found abnormal brain function and white matter organ... | [
[
"40446445",
"Optimizing mesenchymal stromal cells priming strategies for tailored effects on the secretome.",
"Mesenchymal stromal cells (MSCs) have emerged as a promising tool in regenerative medicine, with recent focus shifting towards their secretome as a cell-free therapeutic approach. This study ... |
35317746 | Comparative study of vestibular projection pathway connectivity in cerebellar injury patients and healthy adults. | Cerebellar injury can not only cause gait and postural instability, nystagmus, and vertigo but also affect the vestibular system. However, changes in connectivity regarding the vestibular projection pathway after cerebellar injury have not yet been reported. Therefore, in the current study, we investigated differences ... | [
[
"29129392",
"Targeting Obesity and Cachexia: Identification of the GFRAL Receptor-MIC-1/GDF15 Pathway.",
"Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFβ) superfamily cytokine implicated in biological and disease pro... | [
[
"34449006",
"Exploring the Concept of Spiritual Sensitivity from the Perspectives of Healthcare Providers in Iran.",
"Spiritual sensitivity (SS) is defined as attention to the available spiritual values in a conflicting situation and awareness of one's roles and responsibilities in that situation. It ... |
37437821 | LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease. | Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been... | [
[
"27766433",
"Midbrain Synchrony to Envelope Structure Supports Behavioral Sensitivity to Single-Formant Vowel-Like Sounds in Noise.",
"Vowels make a strong contribution to speech perception under natural conditions. Vowels are encoded in the auditory nerve primarily through neural synchrony to tempora... | [
[
"36808307",
"Neurobiological correlates and attenuated positive social intention attribution during laughter perception associated with degree of autistic traits.",
"Laughter plays an important role in group formation, signaling social belongingness by indicating a positive or negative social intentio... |
36770411 | Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows. | A systematic study on laser-induced heating carried out in two biological windows (800 nm and 1053 nm) for Fe<sub | [
[
"34411327",
"The Coax Dipole: A fully flexible coaxial cable dipole antenna with flattened current distribution for body imaging at 7 Tesla.",
"The coax dipole antenna, a flexible antenna for body imaging at 7T is presented. Similar to the high impedance coil, this coaxial cable antenna is fed on the ... | [
[
"37738741",
"Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes.",
"Intracortical microelectrodes that can record and stimulate brain activity have become a valuable technique for basic science research and clinical applications. However, long-term... |
37954642 | Case series: Intraoperative neuromonitoring and angiography in the surgical treatment of vascular malformations. | In the surgical treatment of cerebral vascular malformations, e.g., aneurysms and arteriovenous malformations, the risk of ischemic complications is 6.7%, and a residual aneurysm is possible in 5.2% of these cases. Ischemic lesions can result in permanent neurological deficits, and a residual aneurysm can lead to the r... | [
[
"25624933",
"Scalp arteriovenous malformations in young.",
"Scalp arteriovenous malformations are an exceptional group of vascular lesions with curious presentations and an elusive natural history. Their detection in the pediatric population is a rarer occurrence. We discuss our experience with five c... | [
[
"36427671",
"The functional connectivity between left insula and left medial superior frontal gyrus underlying the relationship between rumination and procrastination.",
"Procrastination is regarded as a prevalent problematic behavior that impairs people's physical and mental health. Although previous... |
40396767 | Case series of CT-fusion and real-time US-guidance in percutaneous RF thermocoagulation for trigeminal rhizotomy. | This case series evaluates the feasibility, safety, and efficacy of real-time computed tomography fusion with ultrasound guidance (CTF-USG) in percutaneous radiofrequency thermocoagulation (RFT) for trigeminal rhizotomy. Traditional imaging modalities such as CT and fluoroscopy lack real-time visualization, increasing ... | [
[
"17274022",
"Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI.",
"We examined the neural substrate of motor response inhibition and performance monitoring in the stop signal task (SST) using event-related functional magnetic resonance imag... | [
[
"39810626",
"Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations.",
"Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a me... |
38152804 | Evaluation of 'Normal' Cognitive Functions and Correlation With MRI Volumetry: Towards a Definition of Vascular Cognitive Impairment. | Introduction It is important to establish criteria to define vascular cognitive impairment (VCI) in India as VCI is an image-based diagnosis and magnetic resonance imaging (MRI) changes resulting from age with prevalent vascular risk factors may confound MRI interpretation. The objective of this study was to establish ... | [
[
"30962628",
"Working memory revived in older adults by synchronizing rhythmic brain circuits.",
"Understanding normal brain aging and developing methods to maintain or improve cognition in older adults are major goals of fundamental and translational neuroscience. Here we show a core feature of cognit... | [
[
"36748121",
"Detecting and treating the protean manifestations of diabetic autonomic neuropathy.",
"The manifestations of diabetic autonomic neuropathy (DAN) are protean and clinically involve multiple systems, including the cardiovascular system, the gastrointestinal system, the genitourinary system ... |
40776133 | Stroke Cohort Construction Using an Automated Clinical Data Collection System: An Experience of a Single Cerebrovascular Specialty Hospital in South Korea. | The growing volume of clinical data necessitates efficient management of Electronic Health Records (EHR) data. Traditional labor-intensive EHR management methods have led to significant risks, including high error rates and data omissions. This study modified and developed EHR templates focusing on key cohort-specific ... | [
[
"24345399",
"Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.",
"The global burden of atrial fibrillation (AF) is unknown.</AbstractText We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global Burden of Disease regio... | [
[
"39481376",
"Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.",
"Transcription factors (TFs) bind combinatorially to cis-regulatory elements, orchestrating transcriptional programs. Although studies of chromatin state and chromosomal i... |
40783178 | Live-attenuated Toxoplasma gondii PruΔpp2a-c mutant elicits protective immunity against toxoplasmosis in mice and cats. | Toxoplasma gondii is a zoonotic protozoan pathogen capable of infecting humans and nearly all warm-blooded animals, and causing substantial economic losses to the livestock industry. Developing an effective vaccine against T. gondii remains an urgent priority for controlling the spread of this zoonotic parasite. In thi... | [
[
"27432990",
"Dynamic neural activity during stress signals resilient coping.",
"Active coping underlies a healthy stress response, but neural processes supporting such resilient coping are not well-known. Using a brief, sustained exposure paradigm contrasting highly stressful, threatening, and violent... | [
[
"40037512",
"A novel ferroptosis inhibitor phenothiazine derivative reduces cell death and alleviates neurological impairments after cerebral hemorrhage.",
"The precise etiology of brain injury induced by intracerebral hemorrhage (ICH) remains unclear. Currently, there are no effective therapeutic opt... |
38195249 | Treatment outcomes for ARUBA-eligible brain arteriovenous malformations: a comparison of real-world data from the NVQI-QOD AVM registry with the ARUBA trial. | Significant controversy exists about the management of unruptured cerebral arteriovenous malformations (AVMs). Results from A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) suggested that intervention increases the risk of stroke/death compared with medical management. However, numerous study ... | [
[
"26156615",
"Management of a solitary pulmonary arteriovenous malformation by video-assisted thoracoscopic surgery and anatomic lingula resection: video and review.",
"Pulmonary arteriovenous malformations are abnormal communications between the pulmonary arterial and venous vasculature leading to a r... | [
[
"39595016",
"The Impact of Virtual Reality as a Rehabilitation Method Using TRAVEE System on Functional Outcomes and Disability in Stroke Patients: A Pilot Study.",
"Stroke is the third leading cause of disability. Virtual reality (VR) has shown promising results in post-stroke rehabilitation. The VR ... |
40371132 | Neural mechanisms of CALM intervention to improve CRCI in breast cancer survivors: an fMRI-based study. | Managing Cancer and Living Meaningfully (CALM) intervention's impact on chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCs) was investigated through resting-state functional magnetic resonance imaging (rs-fMRI) to elucidate the underlying neural mechanisms involved.</AbstractText 68 BCs we... | [
[
"33308061",
"Why do imagery and perception look and feel so different?",
"Despite the past few decades of research providing convincing evidence of the similarities in function and neural mechanisms between imagery and perception, for most of us, the experience of the two are undeniably different, why... | [
[
"39707024",
"Mechanical signaling through membrane tension induces somal translocation during neuronal migration.",
"Neurons migrate in a saltatory manner by repeating two distinct steps: extension of the leading process and translocation of the cell body. The former step is critical for determining t... |
37160674 | Antitrust as a Guardrail for Socially Responsible Neurotechnology Design. | The neurotechnology sector is likely to develop under pressure towards commercialized, nonmedical products and may also undergo market consolidation. This possibility raises ethical, social, and policy concerns about the future responsibility of neurotechnology innovators and companies for high-consequence design decis... | [
[
"24904404",
"Decoding spectrotemporal features of overt and covert speech from the human cortex.",
"Auditory perception and auditory imagery have been shown to activate overlapping brain regions. We hypothesized that these phenomena also share a common underlying neural representation. To assess this,... | [
[
"36889873",
"Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring.",
"Although implantable cardioverter-defibrillator (ICD) therapies are associated with increased morbidity and mortality, the prediction of malignant ventricular arrhythmias has remained elusive.</AbstractText... |
37756592 | Attention-based generative adversarial networks improve prognostic outcome prediction of cancer from multimodal data. | The prediction of prognostic outcome is critical for the development of efficient cancer therapeutics and potential personalized medicine. However, due to the heterogeneity and diversity of multimodal data of cancer, data integration and feature selection remain a challenge for prognostic outcome prediction. We propose... | [
[
"32300047",
"Categorical Signaling of the Strongest Stimulus by an Inhibitory Midbrain Nucleus.",
"The nucleus isthmi pars magnocellularis (Imc), a group of inhibitory neurons in the midbrain tegmentum, is a critical component of the spatial selection network in the vertebrate midbrain. It delivers lo... | [
[
"37043357",
"Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone.",
"The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSC... |
39387957 | Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion. | Glioblastoma's infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells' nest, with tumors in contact with these zones exhibiting worse outcomes and more ... | [
[
"26798224",
"Pre-Operative Perfusion Skewness and Kurtosis Are Potential Predictors of Progression-Free Survival after Partial Resection of Newly Diagnosed Glioblastoma.",
"To determine whether pre-operative perfusion skewness and kurtosis derived from normalized cerebral blood volume (nCBV) histogram... | [
[
"40726664",
"A retrospective observational study of clinical and electrophysiological types of Guillain-Barre syndrome from Delhi.",
"To understand the demographic characteristics (age, sex and comorbidities), distribution of electrodiagnostic subtypes, and severity and prognosis of Guillain-Barre syn... |
39163384 | Childhood family socioeconomic status is linked to adult brain electrophysiology. | A large body of research has linked childhood family socioeconomic status (SES) to neurodevelopment in childhood and adolescence. However, it remains unclear to what extent childhood family SES relates to brain functioning in adulthood. To address this gap, the present study investigated the associations between retros... | [
[
"15131523",
"The role of GABA in the pathophysiology and treatment of anxiety disorders.",
"Mechanisms underlying the pathological characteristics of the various anxiety disorders have yet to be fully elucidated. One of the most widely accepted mediators known to play a central role in the pathophysio... | [
[
"38472551",
"Ocrelizumab use in multiple sclerosis: a real-world experience in a changing therapeutic scenario.",
"CD20-depleting therapies are a real milestone in the treatment of multiple sclerosis (MS). This study examined the ocrelizumab (OCR) use in patients with primary progressive (PP) and... |
40011296 | Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain. | Sepsis-associated encephalopathy (SAE) is common and has poor clinical outcome. Sepsis increases autophagy in the brain. This study was designed to determine the role of autophagy on SAE including the brain structures related to learning and memory and the effects of pyrrolidine dithiocarbamate (PDTC), an anti-inflamma... | [
[
"37331262",
"Treatment outcomes of Veteran men in a comprehensive dialectical behavior therapy program: Characterizing sex differences in symptom trajectories.",
"Dialectical Behavior Therapy (DBT) is one of the primary psychosocial treatments for reducing suicidal behaviors and improving psychosocial... | [
[
"40543407",
"Exploring gastrocnemius medialis behavior during gait in children with cerebral palsy across different gait patterns.",
"Children with spastic cerebral palsy show varied gait patterns and muscle morphological alterations. We explored gastrocnemius medialis behavior during gait in typicall... |
35065321 | Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways. | Mercuric chloride (HgCl<sub | [
[
"3025747",
"A new mechanism for induced vitamin D deficiency in calcium deprivation.",
"Synthesis of vitamin D in the skin in response to ultraviolet light is the main determinant of vitamin D status in man and it is therefore surprising that rickets and osteomalacia, clinical signs of vitamin D defic... | [
[
"36685218",
"Sources of residual autocorrelation in multiband task fMRI and strategies for effective mitigation.",
"Analysis of task fMRI studies is typically based on using ordinary least squares within a voxel- or vertex-wise linear regression framework known as the general linear model. This use pr... |
34324976 | Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T. | Mapping mesoscopic cortical functional units such as columns or laminae is increasingly pursued by ultra-high field (UHF) functional magnetic resonance imaging (fMRI). The most popular approach for high-resolution fMRI is currently gradient-echo (GE) blood oxygenation level-dependent (BOLD) fMRI. However, its spatial a... | [
[
"32936488",
"Segmented K-space blipped-controlled aliasing in parallel imaging for high spatiotemporal resolution EPI.",
"A segmented k-space blipped-controlled aliasing in parallel imaging (skipped-CAIPI) sampling strategy for EPI is proposed, which allows for a flexible choice of EPI factor and phas... | [
[
"23103517",
"Towards a neural circuit model of verbal humor processing: an fMRI study of the neural substrates of incongruity detection and resolution.",
"The present study builds on our previous study within the framework of Wyer and Collin's comprehension-elaboration theory of humor processing. In t... |
30605083 | Adaptive Matching Transmitter With Dual-Band Antenna for Intraoral Tongue Drive System. | The intraoral Tongue Drive System (iTDS) is a wireless assistive technology that detects users' voluntary tongue gestures, and converts them to user-defined commands, enabling them to access computers and navigate powered wheelchairs. In this paper, we presented a transmitter (Tx) with adaptive matching and three bands... | [
[
"23556919",
"A prototype MR insertable brain PET using tileable GAPD arrays.",
"The aim of this study was to develop a prototype magnetic resonance (MR)-compatible positron emission tomography (PET) that can be inserted into a MR imager and that allows simultaneous PET and MR imaging of the human brai... | [
[
"29446125",
"Feasibility of high spatiotemporal resolution for an abbreviated 3D radial breast MRI protocol.",
"To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam.</Abs... |
39730017 | Forsythoside B ameliorates neuroinflammation via inhibiting NLRP3 inflammasome of glial cells in experimental autoimmune encephalomyelitis mice. | Neuroinflammation mediated by glial cells plays a crucial role in demyelination in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS) model. Forsythoside B (FTS·B), a natural phenylethanoid glycoside isolated from the dried fruits and leaves of Forsythia suspensa (Thunb.) Vahl, has been fou... | [
[
"31740269",
"Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.",
"Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of... | [
[
"39934999",
"MacaqueNet: Advancing comparative behavioural research through large-scale collaboration.",
"There is a vast and ever-accumulating amount of behavioural data on individually recognised animals, an incredible resource to shed light on the ecological and evolutionary drivers of variation in... |
16196033 | Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. | Chemokines and their receptors are well described in the immune system, where they promote cell migration and activation. In the central nervous system, chemokine has been implicated in neuroinflammatory processes. However, an increasing number of evidence suggests that they have regulatory functions in the normal nerv... | [
[
"36857176",
"Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.",
"Kainate receptors (KARs) are a subtype of ionotropic glutamate receptors that control synaptic transmission in the central nervous system and are implicated in neurological, ... | [
[
"38010204",
"Associations between white matter integrity of the cingulum bundle, surrounding gray matter regions, and cognition across the dementia continuum.",
"Previous Alzheimer's disease and related dementias (AD/ADRD) research studies have illustrated the significance of studying alterations in w... |
34132175 | Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues. | Sporadic Creutzfeldt-Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we used sensitive real-time quaking-induced conversion (RT-QuIC) assays to test fo... | [
[
"29186501",
"The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.",
"Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is accompanied by the misfolding of other p... | [
[
"33143627",
"Diabetes and Its Complications: Therapies Available, Anticipated and Aspired.",
"Worldwide, diabetes ranks among the ten leading causes of mortality. Prevalence of diabetes is growing rapidly in low and middle income countries. It is a progressive disease leading to serious co-morbidities... |
40717422 | Empowering learners through student-led integration of environmental health into small group discussions. | With ongoing climate change and other major human-induced changes to the biosphere, there is a greater need to improve future healthcare providers' environmental health (EH) literacy. As of 2022, 45% of U.S. MD programs lacked a required EH curriculum. A self-assembled group of four medical students conceptualized and ... | [
[
"40282146",
"Exploring the Complexity of Children's Math and Vocabulary Learning: The Role of Cognitive, Dispositional, and Parental Factors.",
"Early mathematical and vocabulary skills serve as critical foundations for academic success, yet the mechanisms underlying their development remain complex. ... | [
[
"40423643",
"Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study.",
"Obstructive Sleep Apnea Syndrome (OSAS) is a heterogeneous syndrome and shows different phenotypic, clinical and physiopathological features. The aim of this study was to examine t... |
38013916 | A Deep Learning Based Anti-aliasing Self Super-resolution Algorithm for MRI. | High resolution magnetic resonance (MR) images are desired in many clinical applications, yet acquiring such data with an adequate signal-to-noise ratio requires a long time, making them costly and susceptible to motion artifacts. A common way to partly achieve this goal is to acquire MR images with good in-plane resol... | [
[
"28074530",
"Slice profile and B(1) corrections in 2D magnetic resonance fingerprinting.",
"The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B<sub The SP and B<sub The SP and B<sub This stud... | [
[
"29938010",
"The Parent Trauma Response Questionnaire (PTRQ): development and preliminary validation.",
"<b <b 背景：在儿童遭受创伤之后，父母的反应在促进或阻碍... |
39989429 | Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort. | Proteomic evaluation of plasma samples could accelerate the identification of novel Alzheimer's disease (AD) biomarkers. We evaluated the novel NUcleic acid Linked Immuno-Sandwich Assay (NULISA) proteomic method in an ethnically diverse cohort.</AbstractText Plasma biomarkers were measured with NULISA in the Human Conn... | [
[
"38020757",
"The key role of depression and supramarginal gyrus in frailty: a cross-sectional study.",
"The age-related decrease in reserve and resistance to stressors is recognized as frailty, one of the most significant challenges identified in recent years. Despite a well-acknowledged association o... | [
[
"40746470",
"Could the sealer thickness affect the filling ability of bioceramic endodontic materials? Evaluation in a simulated physiological condition.",
"Bioceramic sealers must provide filling and dimensional stability over time.</AbstractText To evaluate by micro-computed tomography (micro-CT), t... |
29434794 | Biomechanical analysis of brachial plexus injury: Availability of three-dimensional finite element model of the brachial plexus. | Adult brachial plexus injuries frequently lead to significant and permanent physical disabilities. Investigating the mechanism of the injury using biomechanical approaches may lead to further knowledge with regard to preventing brachial plexus injuries. However, there are no reports of biomechanical studies of brachial... | [
[
"28624567",
"Results of Operative Treatment of Brachial Plexus Injury Resulting from Shoulder Dislocation: A Study with A Long-Term Follow-Up.",
"Injury to the infraclavicular brachial plexus is an uncommon but serious complication of shoulder dislocation. This work aims to determine the effectiveness... | [
[
"28525629",
"The Association of Perceived Memory Loss with Osteoarthritis and Related Joint Pain in a Large Appalachian Population.",
"Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the seco... |
15528098 | Semantic processing of Chinese in left inferior prefrontal cortex studied with reversible words. | This study utilized fast event-related fMRI with reversible words to examine the role of left inferior prefrontal cortex (PFC) in semantic processing of Chinese. As a special linguistic phenomenon in Chinese, a reversible word is a two-character word (AB) that, when read from right to left (BA), opposite to the normal ... | [
[
"33540359",
"The only-child effect in the neural and behavioral signatures of trust revealed by fNIRS hyperscanning.",
"In daily life, trust is important in interpersonal interactions. However, little is known about interpersonal brain synchronization with respect to trust; in particular, the differen... | [
[
"40216214",
"Brain-based gene expression and corresponding behavioural relevance of risk genes for broad antisocial behaviour.",
"Antisocial behaviour (ASB) involves persistent irresponsible, delinquent activities violating rights and safety of others. A meta-analysis of genome-wide association studie... |
40088962 | Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models. | Malignant astrocytomas are aggressive primary brain tumors characterized by extensive hypoxia-induced, mitochondria-dependent changes such as altered respiration, increased chymotrypsin-like (CT-L) proteasome activity, decreased apoptosis, drug resistance, stemness, and increased invasiveness. Mitochondrial Lon Peptida... | [
[
"33204688",
"Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database.",
"Hemangiopericytomas are rare tumors derived from pericytes surrounding the blood vessels. The clinicopathological characteristics and prognosis of hemangiopericytoma patients remain mostly unknown.... | [
[
"40753796",
"Acupressure as a non-pharmacological treatment for depression: Neurophysiological, biochemical, and psychological mechanisms.",
"Depression is a common and serious psychological disorder with high prevalence and recurrence rates. Still, there are treatment-resistant depression in the clin... |
26041961 | Magnetic resonance imaging and spectroscopy in hepatic encephalopathy. | Hepatic encephalopathy is a brain alteration associated to liver failure that produces cognitive impairments at long term. Neuroimaging are non-invasive methods for the study of the brain by means of spectroscopy and imaging techniques. These technologies give huge information about cerebral metabolism and water distri... | [
[
"18321730",
"Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology.",
"Myelin water imaging (MWI) promises to be invaluable in understanding neurological diseases like MS. However, a limitation of MWI is signal to noise ratio. Recently, a number of investigators have perf... | [
[
"25860885",
"Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes.",
"The aim of this study is to investigate the association between serum albumin concentrations and nerve conduction (NC) parameters in Chinese patients with type 2 diabetes (T2DM). A total of 409... |
35467010 | Different characteristics of cortical spreading depression in the sleep and wake states. | The objective of this study is to characterize the effects of the sleep-wake cycle on neurovascular and behavioral characteristics of cortical spreading depression (CSD).</AbstractText There is an important bi-directional relationship between migraine and the sleep-wake cycle, but the basic mechanisms of this relations... | [
[
"32677977",
"Compressed-sensing accelerated 4D flow MRI of cerebrospinal fluid dynamics.",
"4D flow magnetic resonance imaging (MRI) of CSF can make an important contribution to the understanding of hydrodynamic changes in various neurological diseases but remains limited in clinical application due t... | [
[
"36573133",
"Weakly-supervised learning method for the recognition of potato leaf diseases.",
"As a crucial food crop, potatoes are highly consumed worldwide, while they are also susceptible to being infected by diverse diseases. Early detection and diagnosis can prevent the epidemic of plant diseases... |
38295508 | Comparison of quantitative REM without atonia parameters in isolated REM sleep behavior disorder and early untreated Parkinson's disease. | To analyze REM sleep without atonia (RWA) metrics in patients with isolated REM sleep behavior disorder (iRBD), Parkinson's disease (PD) and healthy subjects and compare them in terms of degree of presumed brainstem damage.</AbstractText Forty-nine iRBD patients, 62 PD patients and 38 healthy controls were included int... | [
[
"38701162",
"Oscillation-Specific Nodal Differences in Parkinson's Disease Patients with Anxiety.",
"Parkinson's disease (PD) is a common neurodegenerative disorder that is predominantly known for its motor symptoms but is also accompanied by non-motor symptoms, including anxiety.</AbstractText The un... | [
[
"39160029",
"Haemodynamic effects of non-Newtonian fluid blood on the abdominal aorta before and after double tear rupture.",
"Intimal tears caused by aortic dissection can weaken the arterial wall and lead to aortic aneurysms. However, the effect of different tear states on the blood flow behaviour r... |
28546311 | Evidence for Functional Networks within the Human Brain's White Matter. | Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. Although numerous studies have identified networks of interacting functional modules in the gray-matter, limited research was directed to the functional organization of the white-matter. Recent studies ha... | [
[
"30911222",
"Strength and Temporal Variance of the Default Mode Network to Investigate Chronic Mild Traumatic Brain Injury in Service Members with Psychological Trauma.",
"There is a significant number of military personnel with a history of mild traumatic brain injury (mTBI) who suffer from comorbid ... | [
[
"12574424",
"Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.",
"The complement system consists of >30 proteins that interact in a carefully regulated manner to destroy invading bacteria and prevent the deposition of immune complexe... |
39111111 | Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. | Post-traumatic stress disorder (PTSD) has been linked to altered communication within the limbic system, including reduced structural connectivity in the uncinate fasciculus (UNC; i.e., decreased fractional anisotropy; FA) and reduced resting-state functional connectivity (RSFC) between the hippocampus and ventromedial... | [
[
"37185137",
"Photochemically induced thalamus infarction impairs cognition in a mouse model.",
"Small subcortical infarcts account for up to 25% of ischaemic strokes. Thalamus is one of the subcortical structures that commonly manifest with lacunar infarcts on MRI of the brain. Studies have shown that... | [
[
"39203743",
"Possible Extracellular Signals to Ameliorate Sarcopenia in Response to Medium-Chain Triglycerides (8:0 and 10:0) in Frail Older Adults.",
"In frail older adults (mean age 85 years old), a 3-month supplementation with a low dose (6 g/day) of medium-chain triglycerides (MCTs; C8:0 and C10:0... |
37838358 | Management of Cholinergic Rebound After Abrupt Withdrawal of Clozapine: A Case Report and Systematic Literature Review. | Cholinergic discontinuation symptoms, also known as "cholinergic rebound," from abrupt clozapine discontinuation are characterized by a range of somatic and psychiatric symptoms.</AbstractText The objective of this study was to describe the clinical features and management options for clozapine withdrawal-associated ch... | [
[
"36449471",
"Impact-Tardive Dyskinesia (Impact-TD) Scale: A Clinical Tool to Assess the Impact of Tardive Dyskinesia.",
"<b"
]
] | [
[
"39554587",
"Plasma levels of progranulin, a tumorigenic protein, are persistently elevated during the first month after minimally invasive colorectal cancer resection.",
"Progranulin (PGRN), also identified as Precursor cell-derived growth factor (PCDGF), is a glycoprotein that is expressed and relea... |
39402611 | Cognitive flexibility predicts attitudes towards vaccination: evidence from a New Zealand sample. | Vaccine hesitancy (the reluctance or refusal to vaccinate) poses a significant threat to public health worldwide, with declining vaccination coverage resulting in the resurgence of vaccine-preventable diseases (e.g., measles) in recent years. Despite efforts to combat vaccine hesitancy through information-based campaig... | [
[
"29287743",
"A novel ex vivo method for measuring whole brain metabolism in model systems.",
"Many neuronal and glial diseases have been associated with changes in metabolism. Therefore, metabolic reprogramming has become an important area of research to better understand disease at the cellular level... | [
[
"38392440",
"Effectiveness of Different Neurocognitive Intervention Approaches on Functionality in Healthy Older Adults: A Systematic Review.",
"Subtle loss of functionality in healthy older adults is considered one of the most important predictors of cognitive decline. Neurocognitive interventions ar... |
39456253 | The Ambivalence of Post COVID-19 Vaccination Responses in Humans. | The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has prompted a massive global vaccination campaign, leading to the rapid development and deployment of several vaccines. Various COVID-19 vaccines are under different phases of clinical trials and i... | [
[
"28500804",
"A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana.",
"From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac f... | [
[
"39053336",
"Two-year mortality and seizure recurrence following status epilepticus in Auckland, New Zealand: A prospective cohort study.",
"To document the 2-year mortality and seizure recurrence rate of a prospective cohort of patients identified with status epilepticus (SE).</AbstractText Patients ... |
39428042 | Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice. | Optineurin (OPTN) is an autophagy receptor that participates in the degradation of damaged mitochondria, protein aggregates, and invading pathogens. OPTN is closely related to various types of neurodegenerative diseases. However, the role of OPTN in the central nervous system is unclear. Here, we found that OPTN dysreg... | [
[
"28554413",
"The Nonmotor Features of Parkinson's Disease.",
"Nonmotor symptoms (NMS) of Parkinson's disease (PD) were recognized by the great James Parkinson himself who mentioned symptoms such as sleep dysfunction, delirium, dementia, and dysautonomia, in his seminal 1817 essay, \"An Essay on the Sh... | [
[
"38315591",
"SARF: Aliasing Relation-Assisted Self-Supervised Learning for Few-Shot Relation Reasoning.",
"Few-shot relation reasoning on knowledge graphs (FS-KGR) is an important and practical problem that aims to infer long-tail relations and has drawn increasing attention these years. Among all the... |
40286791 | B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8(+) T cell function. | Liver regeneration (LR) is essential for recovery from acute trauma, cancer surgery, or transplantation. Neurotransmitters such as acetylcholine (ACh) play a role in LR by stimulating immune cells and augmenting hepatocyte proliferation, but the source of this ACh remains unclear. Here, we demonstrated that B cells exp... | [
[
"21746786",
"SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.",
"We tested the hypothesis that reductions in the cellular deacetylase, sirtuin-1 (SIRT-1), contribute to vascular endothelial dysfunction with ageing via modulation of endothelial nitric oxide synthase (eNOS) ac... | [
[
"40725047",
"Exploring the Interplay Between Gut Microbiota and the Melatonergic Pathway in Hormone Receptor-Positive Breast Cancer.",
"Emerging evidence suggests a bidirectional relationship between gut microbiota, melatonin synthesis, and breast cancer (BC) development in hormone receptor-positive p... |
37818027 | 18F-fluoro-2-deoxy-2-d-glucose PET-CT (FDG PET-CT) in staging of high-risk renal and urothelial bladder cancers (COPPER-T) trial protocol. | Role of <sup There will be two subgroups of patients: RCC and urinary bladder carcinoma. In each of these, the patients will be randomized to either Arm A or Arm B. In each of the arms, each patient will be subjected to diagnostic imaging by FDG PET-CT. The CT scan will be a contrast-enhanced scan like that in conventi... | [
[
"32906630",
"Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study.",
"The aim of this study was to analyze patients diagnosed, staged and treated for orbital and eyelid B-cell lymphoma (OEL).</AbstractText One hundred and forty-one cases of OEL were included in this study. Primary end... | [
[
"37645082",
"Validity and Reliability of the Pictures of Facial Affect (POFA) in Healthy People and Patients with Essential Tremor in the Turkish Population.",
"This study aimed to conduct the validity and reliability of the (Pictures of Facial Affect) POFA test for the Turkish population and contribu... |
35403392 | [Modulation of transcutaneous auricular vagus nerve stimulation on default mode network in patients with primary insomnia]. | To explore the modulation of transcutaneous auricular vagus nerve stimulation (taVNS) on default mode network (DMN) in patients with primary insomnia (PI).</AbstractText A total of 22 PI patients (one patient dropped off and two patients were excluded) were included and treated with taVNS. The bilateral auricular point... | [
[
"17599700",
"Recent advances in magnetic resonance neurospectroscopy.",
"Over the past two decades, proton magnetic resonance spectroscopy (proton MRS) of the brain has made the transition from research tool to a clinically useful modality. In this review, we first describe the localization methods cu... | [
[
"35218310",
"GSH-Responsive Metal-Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy.",
"Immunotherapy brings great benefits for tumor therapy in clinical treatments but encounters the severe challenge of low response rate mainly because of the immuno... |
39735539 | Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia. | Preeclampsia (PE) is a pregnancy complication characterized by hypertension, proteinuria, endothelial dysfunction, and complement dysregulation. Placenta-derived extracellular vesicles (EVs), necessary in maternal-fetal communication, might contribute to PE pathogenesis. Moreover, neutrophil extracellular traps (NETs) ... | [
[
"37766893",
"Advantages of photo-curable collagen-based cell-laden bioinks compared to methacrylated gelatin (GelMA) in digital light processing (DLP) and extrusion bioprinting.",
"The development of cell-laden bioinks that possess high biocompatibility and printability is crucial in the field of biop... | [
[
"38342980",
"Improving quantitative MRI using self-supervised deep learning with model reinforcement: Demonstration for rapid T1 mapping.",
"This paper proposes a novel self-supervised learning framework that uses model reinforcement, REference-free LAtent map eXtraction with MOdel REinforcement (RELA... |
40714509 | The function and application potential of L-theanine: From biotechnological production, biosynthesis, bioactivity to food industry. | L-theanine (γ-glutamylethylamide), a unique amino acid predominantly biosynthesized in tea plants (Camellia sinensis), exhibits multifaceted roles in human health and food innovation. This review elucidates its biosynthesis regulated by nitrogen availability and epigenetic mechanisms, alongside sustainable biotec... | [
[
"32621777",
"Association between tear and blood glucose concentrations: Random intercept model adjusted with confounders in tear samples negative for occult blood.",
"To prevent diabetic complications, strict glucose control and frequent monitoring of blood glucose levels with invasive methods are nec... | [
[
"40744504",
"Effects of N-Acetylcysteine and l-Carnitine on Wound Healing of Palatal Mucosa in a Rat Model.",
"Surgical procedures in oral and maxillofacial surgery inevitably cause wound formation, making the patient vulnerable to infections as well as discomfort. As antioxidant agents exert great po... |
40689283 | Evaluating Children's Drawings as a Means of Expression in Children with Chronic Diseases. | Children's drawings are considered an important tool for detecting emotions and experiences that a child may be unable or unwilling to express verbally.</AbstractText This study aimed to assess the emotional state, psychological development, and adjustment mechanisms of children with chronic diseases using projective d... | [
[
"37966840",
"Ascertainment of Minimal Clinically Important Differences in the Diabetes Distress Scale-17: A Secondary Analysis of a Randomized Clinical Trial.",
"The Diabetes Distress Scale-17 (DDS-17) is a common measure of diabetes distress. Despite its popularity, there are no agreed-on minimal cli... | [
[
"39988194",
"The intrinsic functional connectivity patterns of the phonological and semantic networks in word reading.",
"Previous studies have revealed that phonological and semantic processing recruit separate brain networks. However, the intrinsic functional connectivity patterns of the phonologica... |
37019439 | Passive Recording of Bioelectrical Signals from Non-Excitable Cells by Fluorescent Mirroring. | Bioelectrical variations trigger different cell responses, including migration, mitosis, and mutation. At the tissue level, these actions result in phenomena such as wound healing, proliferation, and pathogenesis. Monitoring these mechanisms dynamically is highly desirable in diagnostics and drug testing. However, exis... | [
[
"12813152",
"Loss of force induced by high extracellular [K+] in rat muscle: effect of temperature, lactic acid and beta2-agonist.",
"Loss of K+ from active muscles, leading to increased [K+]o, has been proposed to cause muscle fatigue by reducing excitability. Since exercise increases muscle temperat... | [
[
"36398570",
"[Metacognitions and interoceptive sensibility in the perception of premonitory urges in tic disorders across the lifespan].",
"Metacognitions and interoceptive sensibility in the perception of premonitory urges in tic disorders across the lifespan <b <b"
]
] |
27861208 | Left Ventricular Myocardial Fibrosis, Atrophy, and Impaired Contractility in Patients With Pulmonary Arterial Hypertension and a Preserved Left Ventricular Function: A Cardiac Magnetic Resonance Study. | Using a cardiac magnetic resonance (CMR) approach we investigated left ventricular (LV) myocardial changes associated with pulmonary arterial hypertension (PAH) by strain analysis and mapping techniques.</AbstractText Seventeen patients with PAH (9 men; mean age, 64.2±13.6 y) and 20 controls (10 men, 63.2±10.... | [
[
"23319072",
"Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes.",
"Investigation of atrophy data from a pivotal natalizumab trial has demonstrated an increased rate of volume loss, compared to placebo, after the first year of therapy. It was considered to be ... | [
[
"28585255",
"Life years lost among patients with a given disease.",
"A number of suggested measures of life years lost among patients with a given disease are reviewed, and some new ones are proposed. The methods are all phrased in the framework of a (Markov or non-Markov) illness-death model in combi... |
37489383 | Management of Migraine-Associated Vestibulocochlear Disorders. | Migraine is a chronic neurological disorder that frequently coexists with different vestibular and cochlear symptoms (sudden hearing loss, tinnitus, otalgia, aural fullness, hyperacusis, dizziness, imbalance, and vertigo) and disorders (recurrent benign positional vertigo, persistent postural perceptual dizziness, mal ... | [
[
"34672361",
"Association Between Asthma and Meniere's Disease: A Nested Case-Control Study.",
"This study aimed to investigate the association between Meniere's disease and prior history of asthma.</AbstractText A nested case-control study.</AbstractText Among the patients aged ≥40 years... | [
[
"37393007",
"Mini-review: \"Enteric glia functions in nervous tissue repair: Therapeutic target or tool?\".",
"In the body, nerve tissue is not only present in the central nervous system, but also in the periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of neurons and... |
37336998 | A sub 1 GHz ultra miniaturized folded dipole patch antenna for biomedical applications. | A miniaturized folded dipole patch antenna (FDPA) design for biomedical applications operating at sub 1 GHz (434 MHz) band is presented. Antenna is fabricated on FR-4 substrate material having dimensions of 16.40 mm [Formula: see text] 8.60 mm [Formula: see text] 1.52 mm (0.023[Formula: see text] [Formula: see text] 0.... | [
[
"33730953",
"Challenges and recommendations for magnetic hyperthermia characterization measurements.",
"The localized heating of magnetic nanoparticles (MNPs) <i An interlaboratory study (across <i The data show that although there is very good intralaboratory repeatability, the overall interlaborator... | [
[
"33568700",
"Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures.",
"SARS-CoV-2 is the causative of the COVID-19 disease, which has spread pandemically around the globe within a few months. It is therefore necessary to collect fundamental infor... |
38754255 | Long-term seizure diary tracking habits in clinical studies: Evidence from the Human Epilepsy Project. | To characterize seizure tracking patterns of people with focal epilepsy using electronic seizure diary entries, and to assess for risk factors associated with poor tracking.</AbstractText We analyzed electronic seizure diary data from 410 participants with newly diagnosed focal epilepsy in the Human Epilepsy Project 1 ... | [
[
"36941137",
"Association of FAT1 with focal epilepsy and correlation between seizure relapse and gene expression stage.",
"The FAT1 gene encodes FAT atypical cadherin 1, which is essential for foetal development, including brain development. This study aimed to investigate the relationship between FAT... | [
[
"39141740",
"Single neuron responses to perceptual difficulty in the mouse auditory cortex.",
"Perceptual learning leads to improvement in behavioral performance, yet how the brain supports challenging perceptual demands is unknown. We used two photon imaging in the mouse primary auditory cortex durin... |
39060866 | Tension hydrothorax complicating syringopleural shunt for post-traumatic syringomyelia. | Syringomyelia is a rare phenomenon that is typically associated with Chiari malformations. However, they can occur in the setting of post-traumatic spinal injury. Potential diversion treatments include syringopleural (SPS), syringoperitoneal and syringosubarachnoid shunts. Short-term complications have been reported in... | [
[
"22186848",
"Trigger factors for rupture of intracranial aneurysms in relation to patient and aneurysm characteristics.",
"Female gender, age above 60 years, and an aneurysm larger than 5 mm or location on the posterior circulation are associated with a higher rupture risk of intracranial aneurysms. W... | [
[
"39705858",
"A minor role for hemispheric specialization in determining pseudoneglect: A pre-registered replication-extension study.",
"Neurologically intact individuals display a mild asymmetry in spatial attention that can be measured during experimental spatial tasks such as line bisection. Althoug... |
39709140 | Safety and efficacy of GLP-1/FGF21 dual agonist HEC88473 in MASLD and T2DM: A randomized, double-blind, placebo-controlled study. | Glucagon-like peptide-1 (GLP-1) and fibroblast growth factor 21 (FGF21) are key regulators of glucose and lipid metabolism. In the present study, we assessed the safety and efficacy of a novel GLP-1/FGF21 dual agonist HEC88473 for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) combine... | [
[
"35842609",
"Utilization of T1-Mapping for the pelvic and thigh muscles in Duchenne Muscular Dystrophy: a quantitative biomarker for disease involvement and correlation with clinical assessments.",
"Little is known about the disease distribution and severity detected by T1-mapping in Duchenne muscular... | [
[
"40634289",
"Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy.",
"Absence of dystrophin protein causes cardiac dysfunction in patients with Duchenne muscular dystrophy (DMD). Unlike boys with DMD, the common mouse model of DMD... |
38958626 | How to Achieve Highly Professional Care in the Postoperative Ward: The Care of Infants and Toddlers. | The purpose of this study was to describe the experiences of critical care nurses (CCNs) and registered nurse anesthetists (RNAs) when monitoring and observing infants and toddlers recovering from anesthesia.</AbstractText A qualitative design with a critical incident approach.</AbstractText Semistructured individual i... | [
[
"32498631",
"Relationships between sleep, exercise timing, and chronotype in young adults.",
"To examine the relationships between exercise timing, chronotype, sleep, and mood, college students (<i"
]
] | [
[
"40558907",
"Stress Distribution on Endodontically Treated Anterior Teeth Restored via Different Ceramic Materials with Varying Post Lengths Versus Endocrown-A 3D Finite Element Analysis.",
"This study aims to evaluate the stress distribution on endodontically treated anterior teeth restored using dif... |
40685869 | Analysis of ALPS-Index: Difference in Type 2 Diabetes Mellitus With or Without Mild Cognitive Impairment and Its Relationship With Hippocampal Microstructure. | Type 2 diabetes mellitus (T2DM) with cognitive impairment has a high incidence rate globally, and there is a need to investigate the relationship among the glymphatic system, hippocampus microstructure, and cognition in T2DM. The present study aims to delineate changes in the perivascular space index (ALPS-index) among... | [
[
"36041852",
"Cortical Ripples during NREM Sleep and Waking in Humans.",
"Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement sleep (NREM). Recently, cortical ripples in humans ha... | [
[
"40404790",
"Early life stress impairs hippocampal subfield myelination.",
"The hippocampus is an archicortical structure that is highly sensitive to experience and is made up of individual subfields. These subfields, crucial for learning and memory, rapidly develop and are vulnerable to early stress,... |
22028681 | The Relationship between Saccadic Choice and Reaction Times with Manipulations of Target Value. | Choosing the option with the highest expected value (EV; reward probability × reward magnitude) maximizes the intake of reward under conditions of uncertainty. However, human economic choices indicate that our value calculation has a subjective component whereby probability and reward magnitude are n... | [
[
"19321780",
"The neurobiology of reference-dependent value computation.",
"A key focus of current research in neuroeconomics concerns how the human brain computes value. Although, value has generally been viewed as an absolute measure (e.g., expected value, reward magnitude), much evidence suggests th... | [
[
"22254584",
"Graphic patterns of cortical functional connectivity of depressed patients on the basis of EEG measurements.",
"Considerable evidences have shown a decrease of neuronal activity in the left frontal lobe of depressed patients, but the underlying cortical network is still unclear. The prese... |
22609941 | Selective loss of AMPA receptors at corticothalamic synapses in the epileptic stargazer mouse. | Absence seizures are common in the stargazer mutant mouse. The mutation underlying the epileptic phenotype in stargazers is a defect in the gene encoding the normal expression of the protein stargazin. Stargazin is involved in the membrane trafficking and synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazo... | [
[
"22344687",
"T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.",
"Absence seizures are a common seizure type in children with genetic generalized epilepsy and are characterized by a temporary loss of awareness, arrest of physical activity, and accompan... | [
[
"22447075",
"Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.",
"Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an underst... |
23986248 | Using IQ discrepancy scores to examine the neural correlates of specific cognitive abilities. | The underlying neural determinants of general intelligence have been studied intensively, and seem to derive from the anatomical and functional characteristics of a frontoparietal network. Little is known, however, about the underlying neural correlates of domain-specific cognitive abilities, the other factors hypothes... | [
[
"17204295",
"Neural correlates of processing facial identity based on features versus their spacing.",
"Adults' expertise in recognizing facial identity involves encoding subtle differences among faces in the shape of individual facial features (featural processing) and in the spacing among features (... | [
[
"23990221",
"Locomotor activity and anxiety status, but not spatial working memory, are affected in mice after brief exposure to cuprizone.",
"Chronic long-term exposure to cuprizone causes severe brain demyelination in mice, which leads to changes in locomotion, working memory and anxiety. These find... |
40620288 | The correlation between muscle strength, inhibitory function, and cognitive function in older adults with cognitive impairment: evidence from resting-state electroencephalography. | This study explored the associations among muscle strength, inhibitory control, and cognitive function in older adults with cognitive impairment, focusing on related EEG changes.</AbstractText Among 247 adults aged 70 and above, 120 with cognitive impairment were included. Assessments included the Montreal Cognitive As... | [
[
"11834781",
"Placebo and opioid analgesia-- imaging a shared neuronal network.",
"It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia,... | [
[
"40097941",
"Integrating parent report, observed behavior, and physiological measures to identify biomarkers of sensory over-responsivity in autism.",
"Sensory over-responsivity (SOR) is a heightened reaction to environmental stimuli commonly seen in autism spectrum disorder (ASD) which impacts daily ... |
34900214 | Role of the Dorsal Posterior Parietal Cortex in the Accurate Perception of Object Magnitude in Peripheral Vision. | Following superior parietal lobule and intraparietal sulcus (SPL-IPS) damage, optic ataxia patients underestimate the distance of objects in the ataxic visual field such that they produce hypometric pointing errors. The metrics of these pointing errors relative to visual target eccentricity fit the cortical magnificati... | [
[
"30692225",
"An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.",
"The posterior parietal cortex (PPC) features close anatomical and functional relationships with the prefrontal cortex. However, the necessity of the PPC in executive functions ... | [
[
"33995766",
"Use of geographic information systems web mapping application to support active case search to guide public health and social measures in the context of COVID-19 in Zimbabwe: a preliminary report to guide replication of methods in similar resource settings.",
"the new coronavirus (COVID-1... |
39280509 | Anti-recoverin Antibody-Associated Post-acute COVID Vaccination Syndrome After BNT162b2 in HLA-B27-Positive Spondylarthritis: A Case Report. | Retinopathy, small fiber neuropathy (SFN), and encephalopathy associated with recoverin antibodies have not been previously reported as side effects of BNT162b2 vaccination in a patient with HLA-B27-associated spondylarthritis. The patient is a 47-year-old male with a 10-year history of HLA-B27-associated spondylarthri... | [
[
"26733600",
"Migraine and its psychiatric comorbidities.",
"Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. In this manuscript, we provide an overview of the link between migraine and several comorbid psychiatric disorders, ... | [
[
"38195625",
"Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.",
"Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (M<sup"
]
] |
37882887 | Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy. | Obesity is a worldwide problem in which genetic factors have a prominent role. We have selected two single nucleotide polymorphisms (SNPs) within glutamate metabotropic receptor 7 (GRM7) gene, namely rs6782011 and rs779867 to weigh their association with obesity in an Iranian cohort. The distribution of rs6782011 allel... | [
[
"20143275",
"Differential sensitivity of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotransfected CHO cell lines. Novel actions of cocaine independent of the DA transporter.",
"The effects of low and high concentrations of cocaine have been studied in vitro on t... | [
[
"36780364",
"Molding Helmet Therapy for Severe Deformational Brachycephaly: Position of Eurion and Therapeutic Effect.",
"Molding helmet therapy is used routinely for moderate to severe deformational plagiocephaly. However, there have been few reports of its use for deformational brachycephaly (DB). T... |
31019105 | Collateral blood flow measurement with intravoxel incoherent motion perfusion imaging in hyperacute brain stroke. | To determine if intravoxel incoherent motion (IVIM) magnetic resonance perfusion can measure the quality of the collateral blood flow in the penumbra in hyperacute stroke.</AbstractText A 6 b values IVIM MRI sequence was acquired in stroke patients with large vessel occlusion imaged <16 hours of last seen well. IVIM... | [
[
"35912523",
"Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus.",
"Febrile status epilepticus (FSE) is an important risk factor for temporal lobe epilepsy and early identification of those at high risk for epilepsy is vital. In a rat model of FSE, we iden... | [
[
"31790563",
"Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia.",
"In patients with probable dementia with Lewy bodies (DLB), overlapping Alzheimer disease pathology is frequent a... |
38957962 | Ileus at Altitude. | Ebert-Santos, Christine, and Ana Campos. Ileus at altitude. <i | [
[
"30578016",
"Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis.",
"IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and effective appro... | [
[
"37995745",
"Adolescent-Onset Epilepsy: Clinical Features and Predictive Factors for First-Year Seizure Freedom.",
"Teenagers with epilepsy require special attention to ensure a successful treatment journey. Our objective was to delineate the clinical characteristics of adolescent-onset epilepsy (AOE)... |
38580877 | Exploring variability in cognitive functioning in patients with spinal muscular atrophy: a scoping review. | The cognitive functioning of individuals with spinal muscular atrophy (SMA) is not well understood, prompting a call for more research to better grasp cognitive involvement in SMA. This study aims to explore recent findings regarding cognitive outcomes in SMA patients, including correlations between clinical features a... | [
[
"38664795",
"Dysregulation of innate immune signaling in animal models of spinal muscular atrophy.",
"Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron (SMN) protein. SMA presents across a broad spectrum of disease ... | [
[
"39289957",
"[Selection of inner ear fenestration strategy and surgical effect of patients with oval window atresia accompanied by facial nerve aberration].",
"<b <b"
]
] |
30203180 | The association between migraine and physical exercise. | There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role exercise plays in migraine prevention is unclear. Here, we review the associations between physical exercise an... | [
[
"21423403",
"Microbial induction of immunity, inflammation, and cancer.",
"The human microbiota presents a highly active metabolic that influences the state of health of our gastrointestinal tracts as well as our susceptibility to disease. Although much of our initial microbiota is adopted from our mo... | [
[
"28990857",
"The role of regional heterogeneity in age-related differences in functional hemispheric asymmetry: an fMRI study.",
"Neuroimaging literature has documented age-related hemispheric asymmetry reduction in frontal regions during task performances. As most studies employed working memory para... |
31408691 | Prion disease and recommended procedures for flexible endoscope reprocessing - a review of policies worldwide and proposal for a simplified approach. | Several guidelines recommend specific treatments for endoscopes, procedures of quarantine for endoscopes, or additional treatments for the endoscope washer disinfector (EWD) in suspected or confirmed cases of Creutzfeldt-Jakob disease (CJD) or variant CJD (vCJD) but vary in many details. This study therefore reviewed g... | [
[
"31088163",
"Speech network regional involvement in bulbar ALS: a multimodal structural MRI study.",
"<i"
]
] | [
[
"32243859",
"Stress Disrupts Human Hippocampal-Prefrontal Function during Prospective Spatial Navigation and Hinders Flexible Behavior.",
"The ability to anticipate and flexibly plan for the future is critical for achieving goal-directed outcomes. Extant data suggest that neural and cognitive stress m... |
22163987 | An innovations-based noise cancelling technique on inverse kepstrum whitening filter and adaptive FIR filter in beamforming structure. | This paper presents an acoustic noise cancelling technique using an inverse kepstrum system as an innovations-based whitening application for an adaptive finite impulse response (FIR) filter in beamforming structure. The inverse kepstrum method uses an innovations-whitened form from one acoustic path transfer function ... | [
[
"11077208",
"Effects of masker frequency and duration in forward masking: further evidence for the influence of peripheral nonlinearity.",
"Forward masking has often been thought of in terms of neural adaptation, with nonlinearities in the growth and decay of forward masking being accounted for by the... | [
[
"20652766",
"Juguloarterial endothelin-1 gradients after severe traumatic brain injury.",
"Endothelin-1 (ET-1) is a potent vasoconstrictor and is thought to be responsible for secondary ischemia and vasogenic edema after traumatic brain injury (TBI). Both CSF and plasma concentrations have been shown ... |
36149680 | Development of a Manual for Disaster Medical Support Using Korean Medicine for Disaster Survivors. | <b | [
[
"23895939",
"White matter in aphasia: a historical review of the Dejerines' studies.",
"The Objective was to describe the contributions of Joseph Jules Dejerine and his wife Augusta Dejerine-Klumpke to our understanding of cerebral association fiber tracts and language processing. The Dejerines (and n... | [
[
"37833406",
"A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory.",
"The pathogenesis of schizophrenia is believed to involve combined dysfunctions of many proteins including microtubule-associated protein 6 (MAP6) and Kv3.1 voltage-gated K<sup"... |
40772555 | Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis. | A better understanding of factors associated with multiple sclerosis (MS) disease activity and disability is needed. Given the strong link between comorbid depression and MS disease activity and disability, we aimed to determine whether the depression genetic burden, as modelled using its polygenic score, is associated... | [
[
"38383156",
"Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials.",
"Seizures are reported to be more prevalent in individuals with multiple sclerosis (MS) compared with the general population. Existing data predominantly originate from populatio... | [
[
"39946538",
"Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling.",
"The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in neuronal signaling throughout the nervou... |
17901391 | Evidence against a perihemorrhagic penumbra provided by perfusion computed tomography. | Several recent studies analyzing perfusion changes in acute intracerebral hemorrhage fed the debate whether there is secondary ischemic tissue damage in the vicinity of intracerebral hemorrhage. We used perfusion CT to address this question.</AbstractText We examined 36 patients between 2001 and 2002 with acute intrace... | [
[
"18055222",
"Accurate prediction of V1 location from cortical folds in a surface coordinate system.",
"Previous studies demonstrated substantial variability of the location of primary visual cortex (V1) in stereotaxic coordinates when linear volume-based registration is used to match volumetric image ... | [
[
"26382174",
"Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack: Three-Year Longitudinal Study.",
"We hypothesized that comorbid amyloid-beta (Aβ) deposition played a key role in long-term cognitive decline in subjects with stroke/transient ischemic attack.</Abstr... |
33794840 | Validation and investigation of cross cultural equivalence of the Fremantle back awareness questionnaire - German version (FreBAQ-G). | Disrupted self-perception of the low back might contribute to chronic non-specific low back pain. The Fremantle back awareness questionnaire is a simple questionnaire to assess back specific self-perception. The questionnaire has recently been translated to German (FreBAQ-G). The aim was to further investigate the psyc... | [
[
"32928886",
"Parallel Processing of Facial Expression and Head Orientation in the Macaque Brain.",
"When we move the features of our face, or turn our head, we communicate changes in our internal state to the people around us. How this information is encoded and used by an observer's brain is poorly u... | [
[
"34082217",
"Differential patterns of dynamic functional connectivity variability in major depressive disorder treated with cognitive behavioral therapy.",
"Numerous studies have shown that major depressive disorder (MDD) is characterized by a range of impairments in emotional and cognitive functions ... |
33194616 | Impact of Positioning Errors on the Dosimetry of Breath-Hold-Based Volumetric Arc Modulated and Tangential Field-in-Field Left-Sided Breast Treatments. | Heart diseases and cardiovascular events are well-known side effects in left-sided breast irradiation. Deep inspiration breath hold (BH) combined with fast delivery techniques such as volumetric modulated arc therapy (VMAT) or tangential field-in-field (TFiF) can serve as a valuable solution to reduce the dose to the h... | [
[
"26795695",
"Characterization of 3D geometric distortion of magnetic resonance imaging scanners commissioned for radiation therapy planning.",
"To develop a method for the assessment and characterization of 3D geometric distortion as part of routine quality assurance for MRI scanners commissioned for ... | [
[
"31713622",
"New developments on the Encyclopedia of DNA Elements (ENCODE) data portal.",
"The Encyclopedia of DNA Elements (ENCODE) is an ongoing collaborative research project aimed at identifying all the functional elements in the human and mouse genomes. Data generated by the ENCODE consortium are... |
39790816 | GFR Estimation and Correlation for Oncology Patients by Two Methods, Gates Method and Dual Time Point Plasma Sampling Method. | With the increasing number of oncology cases and a parallel surge in chemotherapeutic drugs for treatment, the treating physicians conducts nephrotoxicity evaluation to provide a personalized dosing strategy. Of the various tests available, glomerular filtration rate (GFR) under gamma camera with help of Gates method h... | [
[
"34928300",
"Association of Antenatal Diet and Physical Activity-Based Interventions With Gestational Weight Gain and Pregnancy Outcomes: A Systematic Review and Meta-analysis.",
"Excessive gestational weight gain (GWG) is common and associated with adverse pregnancy outcomes. Antenatal lifestyle inte... | [
[
"38844342",
"Cerebral Gray Matter May Not Explain Sleep Slow-Wave Characteristics after Severe Brain Injury.",
"Sleep slow waves are the hallmark of deeper non-rapid eye movement sleep. It is generally assumed that gray matter properties predict slow-wave density, morphology, and spectral power in hea... |
25536499 | (S)-citalopram influences amygdala modulation in healthy subjects: a randomized placebo-controlled double-blind fMRI study using dynamic causal modeling. | Citalopram and Escitalopram are gold standard pharmaceutical treatment options for affective, anxiety, and other psychiatric disorders. However, their neurophysiologic function on cortico-limbic circuits is incompletely characterized. Here we studied the neuropharmacological influence of Citalopram and Escitalopram on ... | [
[
"16680688",
"BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: parallel-acquired inhomogeneity-desensitized fMRI.",
"Functional MRI (fMRI) generally employs gradient-echo echo-planar imaging (GE-EPI) to measure blood oxygen level-dependent (BOLD) signal changes that resu... | [
[
"26286206",
"Use of perampanel in one case of super-refractory hypoxic myoclonic status: Case report.",
"Proper treatment of hypoxic myoclonic status is not clearly determined. Induced hypothermia is improving prognosis and a more aggressive treatment might be beneficial in some patients. Among the ne... |
24834409 | Tools for cardiovascular magnetic resonance imaging. | In less than fifteen years, as a non-invasive imaging option, cardiovascular MR has grown from a being a mere curiosity to becoming a widely used clinical tool for evaluating cardiovascular disease. Cardiovascular magnetic resonance imaging (CMRI) is now routinely used to study myocardial structure, cardiac function, m... | [
[
"1523332",
"Minimum scan speeds for suppression of motion artifacts in CT.",
"Cardiac and ventilatory motions cause artifacts at chest computed tomography (CT). To determine how short the scan times on third-generation units must be to avoid such artifacts, motion was measured with fast and ultrafast ... | [
[
"24741031",
"Seeing scenes: topographic visual hallucinations evoked by direct electrical stimulation of the parahippocampal place area.",
"In recent years, functional neuroimaging has disclosed a network of cortical areas in the basal temporal lobe that selectively respond to visual scenes, including... |
38165551 | Reducing pediatric total-body PET/CT imaging scan time with multimodal artificial intelligence technology. | This study aims to decrease the scan time and enhance image quality in pediatric total-body PET imaging by utilizing multimodal artificial intelligence techniques.</AbstractText A total of 270 pediatric patients who underwent total-body PET/CT scans with a uEXPLORER at the Sun Yat-sen University Cancer Center were retr... | [
[
"33545580",
"Optical brain imaging and its application to neurofeedback.",
"Besides passive recording of brain electric or magnetic activity, also non-ionizing electromagnetic or optical radiation can be used for real-time brain imaging. Here, changes in the radiation's absorption or scattering allow ... | [
[
"39061402",
"Creatine Kinase and Respiratory Decline in Amyotrophic Lateral Sclerosis.",
"Respiratory dysfunction is an important hallmark of amyotrophic lateral sclerosis (ALS). Elevation of creatine kinase (CK) has been reported in 23-75% of ALS patients, but the underlying mechanisms remain unknown... |
40016658 | Effects of multisystem exercises on balance, postural stability, mobility, walking speed, and pain in patients with diabetic peripheral neuropathy: a randomized controlled trial. | Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, is associated with peripheral nerve damage, leading to balance impairments, postural instability, and reduced mobility. Addressing these challenges requires comprehensive interventions that target multiple deficits simultaneously. Evidenc... | [
[
"29430561",
"The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K(+) stimulation but not cortical spreading depression-induced afferent sensitization.",
"Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing ... | [
[
"40618797",
"Preparation, characterization, and functional properties of zein/gallic acid/sodium alginate ternary composite nanoparticles for enhancing stability and bioaccessibility of phytosterols.",
"Phytosterols, a class of phytochemicals exhibiting limited aqueous solubility and low oil solubilit... |
40720222 | How Solvation Structures Define the Cryoprotection Efficiency of Ethylene Glycol. | Understanding the molecular mechanisms of cryopreservation is crucial for optimizing antifreeze formulations. In this study, we investigate the hydrogen bond (HB) configurations of aqueous ethylene glycol (EG) solutions using a combined approach of Fourier transform infrared (FTIR) spectroscopy and molecular dynamics (... | [
[
"38482933",
"Varying the degree of oxidation of graphite: effect of oxidation time and oxidant mass.",
"In this work, we employ a fast and less toxic modified Hummers' method to develop graphene oxide (GO) with varying degrees of oxidation and investigate the effect of the latter on the structure and ... | [
[
"40655172",
"Addiction Education in the Undergraduate Space: A Novel Course Connecting Neurobiology of Addiction and Compassion for Individuals with Substance Use Disorder.",
"Substance use disorder (SUD) is a chronic, relapsing disease with medical, psychological, and social complications. Sufficient... |
20633659 | Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children. | Recent theories of developmental dyslexia explain reading deficits in terms of deficient phonological awareness, attention, visual and auditory processing, or automaticity. Since dyslexia has a neurobiological basis, the question arises how the reader's proficiency in these cognitive variables affects the brain regions... | [
[
"11163606",
"Unilateral vibrotactile stimulation induces emotional biases in cognition and performance.",
"We administered 24 min of unilateral vibrotactile stimulation to the left or right ventral forearm of experimental participants. A separate control group did not receive stimulation but completed... | [
[
"27751941",
"Sources and implications of whole-brain fMRI signals in humans.",
"Whole-brain fMRI signals are a subject of intense interest: variance in the global fMRI signal (the spatial mean of all signals in the brain) indexes subject arousal, and psychiatric conditions such as schizophrenia and au... |
38415151 | Myelin water quantification in multiple sclerosis using short repetition time adiabatic inversion recovery prepared-fast spin echo (STAIR-FSE) imaging. | Myelin water imaging (MWI) is a myelin-specific technique, which has great potential for the assessment of demyelination and remyelination. This study develops a new MWI method, which employs a short repetition time adiabatic inversion recovery (STAIR) technique in combination with a commonly used fast spin echo (FSE) ... | [
[
"29908362",
"Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.",
"Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of... | [
[
"37918767",
"A powerful metric for expressive language lateralization in MEG.",
"Magnetoencephalography (MEG) has proven valuable for presurgical language lateralization. Investigators have established that low-beta (13-23 Hz) event-related desynchrony (ERD), a neuromagnetic signature for increas... |
38819648 | Haptic and visuo-haptic impairments for object recognition in children with autism spectrum disorder: focus on the sensory and multisensory processing dysfunctions. | Dysfunctions in sensory processing are widely described in individuals with autism spectrum disorder (ASD), although little is known about the developmental course and the impact of these difficulties on the learning processes during the preschool and school ages of ASD children. Specifically, as regards the interplay ... | [
[
"16768363",
"Electrophysiological evidence of the capture of visual attention.",
"We investigated the ability of salient yet task-irrelevant stimuli to capture attention in two visual search experiments. Participants were presented with circular search arrays that contained a highly salient distractor... | [
[
"38386744",
"The macroevolutionary singularity of snakes.",
"Snakes and lizards (Squamata) represent a third of terrestrial vertebrates and exhibit spectacular innovations in locomotion, feeding, and sensory processing. However, the evolutionary drivers of this radiation remain poorly known. We infer ... |
27608601 | Elucidating the neural correlates of related false memories using a systematic measure of perceptual relatedness. | Previous memory research has exploited the perceptual similarities between lures and targets in order to evoke false memories. Nevertheless, while some studies have attempted to use lures that are objectively more similar than others, no study has systematically controlled for perceptual overlap between target and lure... | [
[
"15772354",
"The roles of the caudate nucleus in human classification learning.",
"The caudate nucleus is commonly active when learning relationships between stimuli and responses or categories. Previous research has not differentiated between the contributions to learning in the caudate and its contr... | [
[
"28147273",
"miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA.",
"During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subse... |
40086873 | Feedback scales the spatial tuning of cortical responses during both visual working memory and long-term memory. | Perception, working memory, and long-term memory each evoke neural responses in visual cortex. While previous neuroimaging research on the role of visual cortex in memory has largely emphasized similarities between perception and memory, we hypothesized that responses in visual cortex would differ depending on the orig... | [
[
"16672292",
"Plasticity in the human central nervous system.",
"Long-term potentiation (LTP) is a well-characterized form of synaptic plasticity that fulfils many of the criteria for a neural correlate of memory. LTP has been studied in a variety of animal models and, in rodents in particular, there i... | [
[
"39716006",
"Isolating Synaptic Vesicles from Neurospheres for Proteomics.",
"This chapter presents an optimized method for isolating synaptic vesicles (SVs) from neurospheres derived from human induced pluripotent stem cells (hiPSCs). The protocol begins with neurosphere cultivation to achieve mature... |
15556023 | Conflict monitoring and anterior cingulate cortex: an update. | One hypothesis concerning the human dorsal anterior cingulate cortex (ACC) is that it functions, in part, to signal the occurrence of conflicts in information processing, thereby triggering compensatory adjustments in cognitive control. Since this idea was first proposed, a great deal of relevant empirical evidence has... | [
[
"16635578",
"Divide and conquer: a defense of functional localizers.",
"Numerous functionally distinct regions of cortex (e.g., V1, MT, the fusiform face area) can be easily identified in any normal human subject in just a few minutes of fMRI scanning. However, the locations of these regions vary acro... | [
[
"15082137",
"Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy.",
"Paclitaxel (Taxol) is one of the most effective and frequently used chemotherapeutics for the treatment of solid tumours. However, paclitaxel produces peripheral neurotoxicity with patients reporti... |
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