"""Shared per-tooth ROI cropping so training / inference / evaluation are consistent.""" import numpy as np from scipy import ndimage as ndi def _fit(a, n): out = np.zeros((n, n, n), dtype=a.dtype) s = [min(n, a.shape[k]) for k in range(3)] out[:s[0], :s[1], :s[2]] = a[:s[0], :s[1], :s[2]] return out def predicted_instances(d, cfg, dev, stage1_ckpt): """Stage-1-driven instance localization (NO GT). We predict the 4-class map and use the DESCRIPTOR-CORE class (3) -- eroded tooth centers that are spatially separated -- to connected-component into individual teeth, exactly like the 'tooth descriptor' idea in Chen 2025 / Duan 2021. Each core's centroid drives an ROI. Cores are matched to GT instances ONLY for evaluation alignment. Returns inst_pred (full-volume instance map) and match {pred_id -> gt_id}.""" import torch from monai.inferers import sliding_window_inference from .models import get_unet img = d["image"].astype(np.float32) s1 = cfg["stage1"] net = get_unet(s1["num_classes"], tuple(s1["channels"])).to(dev) st = torch.load(stage1_ckpt, map_location=dev) net.load_state_dict(st["model"]); net.eval() with torch.no_grad(): x = torch.from_numpy(img[None, None]).to(dev) logits = sliding_window_inference(x, tuple(s1["patch_size"]), 2, net, overlap=0.25) pred = torch.argmax(logits, 1)[0].cpu().numpy() use_desc = bool(s1.get("use_descriptor", True)) and (pred == 3).any() seed_mask = (pred == 3) if use_desc else (pred == 1) tooth_pred = (pred == 1) | (pred == 3) # full tooth region (core counts as tooth) # connected components on the separable seed cores lab, n = ndi.label(seed_mask, structure=np.ones((3, 3, 3))) inst_pred = np.zeros_like(lab, np.int16) match = {} gt_inst = d.get("inst") min_core = int(cfg["stage1"].get("min_core_voxels", 80)) sp = np.asarray(d.get("spacing", np.ones(3)), np.float32) merge_mm = float(cfg["stage1"].get("core_merge_mm", 3.0)) # over-split fix # 1) keep valid cores + their centroids (mm) cores = [] for k in range(1, n + 1): m = (lab == k) if m.sum() < min_core: continue cores.append((k, np.array(ndi.center_of_mass(m)) * sp)) # 2) union-find: merge cores whose centroids are within merge_mm of each other. # Fragments of ONE tooth's eroded core sit 0: for i in range(len(cores)): for j in range(i + 1, len(cores)): if np.linalg.norm(cores[i][1] - cores[j][1]) < merge_mm: ri, rj = _find(i), _find(j) if ri != rj: parent[ri] = rj from collections import defaultdict groups = defaultdict(list) for idx, (k, _c) in enumerate(cores): groups[_find(idx)].append(k) # 3) grow each (merged) core group back out to recover the full tooth next_id = 1 erode_iter = int(cfg["preprocess"].get("descriptor_erode_iter", 3)) + 2 for klist in groups.values(): core = np.zeros_like(lab, bool) for k in klist: core |= (lab == k) grown = core.copy() for _ in range(erode_iter): grown = ndi.binary_dilation(grown, iterations=1) & tooth_pred cid = next_id; next_id += 1 inst_pred[grown] = cid if gt_inst is not None: ov = gt_inst[grown]; ov = ov[ov > 0] if len(ov) > 0: vals, counts = np.unique(ov, return_counts=True) match[cid] = int(vals[np.argmax(counts)]) return inst_pred, match def crop_roi(d, iid, roi_mm, roi_vox, mask_for_center=None, center_mode="com"): """Crop a physical roi_mm cube around tooth `iid`, resample to roi_vox^3. d: processed npz dict with image/inst/cinst/spacing/origin. center_mode: 'com' (center of mass), 'bbox' (bounding-box center, stabler for tilted/multi-root teeth), or 'hybrid' (mean of the two). Returns dict(img, solid, canal, roi_sp, lo_world_mm, boundary_touch, ...) or None. """ img = d["image"]; inst = d["inst"]; cinst = d["cinst"] sp = np.asarray(d["spacing"], dtype=np.float32) origin = np.asarray(d.get("origin", np.zeros(3)), dtype=np.float32) center_mask = mask_for_center if mask_for_center is not None else (inst == iid) if not center_mask.any(): return None com_mass = np.array(ndi.center_of_mass(center_mask)) if center_mode in ("bbox", "hybrid"): pts = np.argwhere(center_mask) com_box = 0.5 * (pts.min(0) + pts.max(0)) com = com_box if center_mode == "bbox" else 0.5 * (com_mass + com_box) else: com = com_mass half_vox = (roi_mm / 2.0) / sp lo = np.floor(com - half_vox).astype(int) hi = np.ceil(com + half_vox).astype(int) shape = np.array(img.shape) lo_c = np.clip(lo, 0, shape - 1) hi_c = np.clip(hi, 1, shape) sl = tuple(slice(int(a), int(b)) for a, b in zip(lo_c, hi_c)) img_c = img[sl] solid_c = (inst == iid)[sl] canal_c = (cinst == iid)[sl] # clipping diagnostic: fraction of the tooth solid lying on the 6 ROI faces. # >0 means crown/root is being cut off -> ROI too small or mis-centered. if solid_c.any(): faces = [solid_c[0, :, :], solid_c[-1, :, :], solid_c[:, 0, :], solid_c[:, -1, :], solid_c[:, :, 0], solid_c[:, :, -1]] boundary_touch = float(sum(int(f.sum()) for f in faces) / (solid_c.sum() + 1e-9)) else: boundary_touch = 0.0 zoom = np.array([roi_vox] * 3) / np.array(img_c.shape) img_r = _fit(ndi.zoom(img_c, zoom, order=1).astype(np.float32), roi_vox) solid_r = _fit(ndi.zoom(solid_c.astype(np.float32), zoom, order=0) > 0.5, roi_vox) canal_r = _fit(ndi.zoom(canal_c.astype(np.float32), zoom, order=0) > 0.5, roi_vox) roi_sp = np.array([roi_mm / roi_vox] * 3, dtype=np.float32) lo_world_mm = origin + lo_c * sp # the ACTUAL physical size covered (may be < roi_mm for teeth clipped at the volume # border). Stamp-back / NIfTI export must use this, not the nominal roi_mm. actual_size_mm = (hi_c - lo_c).astype(np.float32) * sp return dict(img=img_r, solid=solid_r, canal=canal_r, roi_sp=roi_sp, lo_world_mm=lo_world_mm, actual_size_mm=actual_size_mm, boundary_touch=boundary_touch, orig_spacing=sp)