from __future__ import annotations import math from dataclasses import dataclass from numbers import Integral, Real from pathlib import Path SOURCE_IDS = { "clean_constant_map": 0, "random_global_mu_r": 1, "custom_heterogeneous": 2, "empirical_map_slice": 3, "stdpopsim_anchor": 4, } DEMOGRAPHY_TYPE_IDS = { # The public, scientific label for a row, coarser than the recipe that drew # it. Four labels went when their recipes did -- exponential growth and # decline, three-epoch and serial founder are all things the continuous # event samplers produce, and which of them a row *is* depends on the # trajectory rather than on which sampler ran, so it is resolved per row. "constant": 0, "random_walk": 1, "bottleneck": 2, "expansion": 3, "contraction": 4, "zigzag": 5, "empirical_human_ne_template": 6, "stdpopsim": 7, } ID_TO_DEMOGRAPHY_TYPE = {v: k for k, v in DEMOGRAPHY_TYPE_IDS.items()} # Append-only recipe IDs preserve the exact generator provenance used by older # datasets, where these values were stored as ``demography_id``. GENERATOR_RECIPE_IDS = { # The recipe a row was drawn from. Ids are dense and start at zero: they # name a sampler in this generator, not a position in its history, and a # dataset written before a change is refused by its schema version long # before any id is read. "constant": 0, "spectral_walk": 1, "size_event": 2, "bottleneck": 3, "multi_event": 4, "event_on_background": 5, "ooa_chain": 6, "exponential": 7, "sawtooth": 8, "literature_sawtooth": 9, "empirical_human_ne_template": 10, "stdpopsim_single_pop": 11, "stdpopsim": 12, } ID_TO_GENERATOR_RECIPE = {v: k for k, v in GENERATOR_RECIPE_IDS.items()} # ``None`` marks recipes whose public type depends on the sampled trajectory. GENERATOR_RECIPE_TO_DEMOGRAPHY_TYPE: dict[str, str | None] = { # ``None`` marks a recipe whose public label is a property of the drawn # trajectory rather than of the sampler: a size change is an expansion or a # contraction depending on its sign. "constant": "constant", "spectral_walk": "random_walk", "size_event": None, "bottleneck": "bottleneck", "multi_event": None, "event_on_background": None, "ooa_chain": "bottleneck", "exponential": None, "sawtooth": "zigzag", "literature_sawtooth": "zigzag", "empirical_human_ne_template": "empirical_human_ne_template", "stdpopsim_single_pop": "stdpopsim", "stdpopsim": "stdpopsim", } HISTORY_FAMILY_BY_DEMOGRAPHY_TYPE = { "constant": "stable", "random_walk": "free_form", "bottleneck": "single_pulse", "exponential_growth": "monotonic_change", "exponential_decline": "monotonic_change", "expansion": "monotonic_change", "contraction": "monotonic_change", "three_epoch": "compound_events", "serial_founder": "compound_events", "zigzag": "oscillatory", "empirical_human_ne_template": "free_form", "stdpopsim": "external_model", } GENERATOR_RECIPE_HISTORY_FAMILY_OVERRIDES = { # Keep the strict ``constant`` public label uncontaminated while still # recognizing the near-constant control as part of the stable family. "near_constant": "stable", } # deCODE 2019 (Halldorsson et al., Science 363:eaau1043): 4,531,535 localised # crossovers, average map resolution 682 bp, native GRCh38. It replaces the # Palsson 2025 table, which is published in 1 Mb windows and so holds nothing # at the scale that breaks haplotype tracts -- its crossover column is this # same map re-binned. Kept beside it for the megabase-scale non-crossover # information, which is a different quantity. # Paths are resolved against ``simulator/assets`` first and the working # directory second, so an installed copy finds its own data from anywhere. DEFAULT_RECOMB_MAP = "maps/decode2019_avg_hg38.bed" DEFAULT_MUT_MAP = "maps/roulette_2023_autosomes_hg38_1000bp.bed" SOURCE_PROB_FIELDS = ( "p_clean_constant", "p_random_global", "p_custom_hetero", "p_empirical_slice", "p_stdpopsim_anchor", ) EMPIRICAL_NE_SOURCE_KEYS = frozenset( { "smcpp_1kg", "phlash_unified", "phlash_super", "msmc2_example", "msmc_im_example", } ) DEMOGRAPHY_PROB_FIELDS = ( "p_constant", "p_spectral_walk", "p_size_event", "p_multi_event", "p_exponential", "p_sawtooth", "p_literature_sawtooth", "p_bottleneck", "p_event_on_background", "p_ooa_chain", "p_empirical_human_ne_template", "p_stdpopsim_single_pop", ) UINT32_MAX = 2**32 - 1 INT16_MAX = 2**15 - 1 FLOAT32_MAX = float.fromhex("0x1.fffffep+127") FLOAT32_MIN_POSITIVE = 2.0**-149 MAX_MSPRIME_RATE = 1.0e-4 MAX_SYNTHETIC_RATE_MULTIPLIER = 200.0 # Effective size bounds, declared here instead of at twenty clip sites. # # The anchor is the project's own real data: ``_empirical_human_ne_template`` # draws its curves from smc++ and phlash run on 1000 Genomes, and measured over # 1,500 draws its support is log10 Ne 2.963 to 5.711. The regular bound leaves # roughly an order of magnitude on each side of that -- a hundred individuals # below, a million above -- which is also exactly the support the samplers # already produced between them, so the distribution is unchanged and only the # reason for it becomes explicit. # # Before this, twenty clip sites used at least five different pairs: 2.7 with # an upper end of 5.7, 5.85 or 5.9 depending on which walk it was, and 200 to # 500,000 or 100 to 1,000,000 for the event samplers. Different samplers # therefore had different supports, and since each has a characteristic curve # shape that is a correspondence between shape and range which holds in this # generator and nowhere in biology. # # Stress samplers keep a wider band on purpose. That is a design choice rather # than an accident, so it is named, and every sample records which band it used. NE_LOG10_BOUNDS = (2.0, 6.0) NE_LOG10_STRESS_BOUNDS = (1.7, 6.3) NE_BOUNDS = (10.0 ** NE_LOG10_BOUNDS[0], 10.0 ** NE_LOG10_BOUNDS[1]) NE_STRESS_BOUNDS = (10.0 ** NE_LOG10_STRESS_BOUNDS[0], 10.0 ** NE_LOG10_STRESS_BOUNDS[1]) MAX_BASELINE_RATE = MAX_MSPRIME_RATE / MAX_SYNTHETIC_RATE_MULTIPLIER @dataclass class Config: dataset_name: str = "DLCoalSim-Core-v0.1" preset: str = "mini" out_dir: str = "./DLCoalSim-Out" seed: int = 12345 force: bool = False demography_mixture_version: str = "v1" n_samples: int = 2000 shard_size: int = 64 compute_chunk_size: int = 16 seq_len: int = 1_000_000 n_haplotypes: int = 32 # Supervised target resolution. Nothing about the latent history depends # on it: histories are continuous functions of time, discretised only far # enough to represent them, so the label grid can move without moving the # ground truth or the random-number stream. time_bins: int = 64 # How much log10 Ne error the piecewise-constant representation of a # continuous history may carry. A flat history costs one epoch and a rough # one costs as many as it needs; msprime's cost is flat in epoch count, so # this buys fidelity against metadata size and simulation time. # # It is set by the finest statistic the label carries, not by its RMSE. The # amplitude and total variation of the mixture have both converged by 0.02, # and the label RMSE against an exact representation is 0.0001 there -- but # half of all adjacent-bin steps in the label are smaller than 0.02, so a # tolerance that size erases turning points: the median spectral walk turns # 5 times at 0.05, 7 at 0.02, and 9 at 0.005 and below, and 9 is the human # anchor the mixture is built against. Costs 70 ms and 12.6 kB per row # against 186 s of simulation, so the tail of the sweep is affordable and # the body of it is not worth saving. demography_resolution_log10: float = 0.005 min_time: float = 50.0 max_time: float = 500_000.0 baseline_mu: float = 1.25e-8 baseline_rec: float = 1.0e-8 p_clean_constant: float = 0.25 p_random_global: float = 0.20 p_custom_hetero: float = 0.35 p_empirical_slice: float = 0.20 p_stdpopsim_anchor: float = 0.00 # The demography mixture. Two rules shape it. First, an axis that is # continuous in nature is one sampler with a continuous parameter, not # several samplers pinned to points along it -- the previous mixture had # 27 named recipes and a measured pairwise separability as low as 0.283 # against a 0.500 chance rate. Second, training weight and evaluation # weight are different things: the last three entries are histories other # people published, and rows drawn from them carry # ``held_out_evaluation`` or ``literature_demography_anchor`` so a split # can keep them out of the training gradient. # Weights were set against a measured quantity rather than a feeling: for # each recipe, the share of its rows whose label standard deviation is # under 0.24 -- the level every architecture arm sits at, so on those rows # a per-row constant predictor already beats every arm we have run. They # carry loss but not discrimination, and they are exactly the rows on which # the level-only shortcut is close to optimal. Across the mixture they # were 31.6% of it. # # Two recipes are deliberately not cut for it. ``constant`` is the control # and is trivial on purpose; without it the model invents structure in flat # data. ``bottleneck`` is 65% trivial by that measure, but only because a # dip occupies a few of 64 log-time bins, so its cross-bin spread is small # however deep it is -- cutting the most studied event in the field to # improve an aggregate metric would be optimising the metric, not the # science. What moved instead is the balance inside the background family, # towards the two recipes that are both realistic and structure-demanding: # the empirical templates, only 13% trivial, and the founder chain, 9%. p_constant: float = 0.04 # Carries what the four random walks, ``near_constant`` and the two # stress walks carried between them. p_spectral_walk: float = 0.200 p_size_event: float = 0.10 p_multi_event: float = 0.08 p_exponential: float = 0.04 p_sawtooth: float = 0.03 # The published sawtooth's own neighbourhood. ``p_sawtooth`` covers the # shape space broadly and reaches this shape only in its tail -- of six # thousand free draws the closest sat 0.199 RMSE away, against 0.312 # between two ordinary draws -- and widening it made that worse, because # more axes buy coverage at the cost of density anywhere in particular. p_literature_sawtooth: float = 0.03 # The most studied event in the field, and ``size_event`` was giving it one # row in fifty: only 12.8% of its draws are a drop of half a decade or more # that ends and comes back. This draws from the same space, tilted onto # that corner. The overlap is deliberate -- the alternative is a broader # prior, which puts less density everywhere rather than more density here. p_bottleneck: float = 0.10 # A moving background with sharp events on it. Across the other recipes # 28.4% of rows carry a sharp event and 41.0% a moving background, but only # 2.7% carry both, against the 11.6% independence would give: every other # recipe is one or the other by construction. This is also the row a # shortcut fails on from either side. p_event_on_background: float = 0.086 p_ooa_chain: float = 0.08 p_empirical_human_ne_template: float = 0.19 # Eighteen single-population models across eight species, verbatim. Error # measured on these is evidence about generalisation in a way that error on # our own prior redrawn can never be, and because each model draws one # fixed trajectory, a run of them is a set of data replicates of a known # history -- which is what makes bias and variance on it readable straight # out of the dataset. phlash's simulation study is built the same way, # three replicates per scenario. # # All eighteen models, so at 2,400 rows in a hundred thousand each gets # about 133 replicates. p_stdpopsim_single_pop: float = 0.024 empirical_ne_template_dir: str = "templates/human_ne" stdpopsim_template_path: str = ( "templates/stdpopsim_single_pop/trajectories.csv" ) empirical_ne_template_source_mix: str = "smcpp_1kg:0.25,phlash_unified:0.60,phlash_super:0.10,msmc2_example:0.04,msmc_im_example:0.01" # The templates are 191 curves whose levels all sit within about half a # decade of each other, so a small shift left this recipe with a level # spread of 0.24 against 0.49 to 0.80 for every other recipe -- enough # that the level alone half-announces which recipe a row came from. empirical_ne_template_log10_shift_sd: float = 0.70 empirical_ne_template_contrast_sd: float = 0.10 empirical_ne_template_time_warp_sd: float = 0.15 empirical_ne_template_bin_noise_sd: float = 0.025 map_segments_min: int = 128 map_segments_max: int = 512 # A ratio, not an amplitude: the observation error's log spread divided by # the true map's own log spread. It used to be absolute, and that cannot # serve two maps at once -- a recombination map's log rate has a standard # deviation near 0.5 across a row and a mutation map's near 0.04, so an # absolute 0.25 left the observed recombination map correlating 0.851 with # the truth and the observed mutation map 0.163. Five to eight times more # noise than signal is not a noisy map, it is no map. observed_map_noise: float = 0.55 # Noise on a real map handed to the model, kept separate from the # synthetic one because it stands for the error in a published map # rather than in a map this code generated. At 0.25 the observed map # correlates 0.993 in log rate with the truth, which is to say it is the # truth; two real maps of one region correlate 0.687 at a kilobase. empirical_map_noise: float = 0.80 hotspot_missing_prob: float = 0.10 recomb_map: str = DEFAULT_RECOMB_MAP mut_map: str = DEFAULT_MUT_MAP # The deCODE bigWig is distributed in cM/Mb; writing the source units # rather than pre-converting keeps the file checkable against UCSC. recomb_map_unit: str = "cM_per_Mb" mut_map_unit: str = "per_bp" mut_map_scale_to_baseline: bool = True # Sites a caller invents. Drawn per row on a log scale across four orders # of magnitude, because what survives variant calling is a property of the # pipeline rather than of the population: a hard-filtered callset and a raw # one are orders of magnitude apart. Covering the range and recording the # draw is the honest treatment; picking one number is not. # # The range is set from what is observable rather than from a per-base # error rate: the share of singletons that are not real. Published # callsets put that anywhere from a few percent after hard filtering to # roughly a third in a raw one, and at a typical effective size a megabase # carries about sixteen hundred singletons, so the rate that spans it runs # from about 1.5e-5 to 6e-4 per base pair. false_variant_rate_per_bp_min: float = 1.5e-5 false_variant_rate_per_bp_max: float = 6.0e-4 genotype_error_min: float = 0.001 genotype_error_max: float = 0.004 missing_rate_min: float = 0.002 missing_rate_max: float = 0.020 # Phasing errors happen between consecutive heterozygous sites, which is # where a phasing algorithm makes a decision, not at a fixed rate per base # pair. Published switch-error rates for statistical phasing are 0.5% to # 2% of adjacent heterozygous pairs. The previous physical-distance rate # of at most 0.05 per Mb produced 1.7 switches per diploid over twenty # megabases where the literature implies roughly a hundred, and it also # mis-weighted the genome: at a fixed rate per base pair a sparse region # accumulates switches it has no heterozygous sites to express. phase_switch_rate_per_het_min: float = 0.002 phase_switch_rate_per_het_max: float = 0.020 enable_stdpopsim: bool = False stdpopsim_species: str = "HomSap" stdpopsim_models: str = "" stdpopsim_contig_length: int = 0 workers: int = 1 compression: bool = True compression_level: int = 1 # The true maps are what makes an oracle ablation possible: hand the model # the map the data was simulated under instead of the one it is given, and # the difference separates "limited by map error" from "limited by not # using the map". With the observed map now genuinely wrong -- it is # re-binned and noised rather than returned on the true breakpoints -- that # question has an answer worth measuring. # # They roughly double a sample on disk, so they are written for a fraction # of rows rather than all of them. An ablation needs statistical power, # not every row. # How much of the genealogy to keep alongside the sequence. # # "none" nothing # "summary" coalescences and branch length per target time bin, two # vectors of 64 floats: 512 bytes a row, 0.08% of the # simulation's runtime, and the sufficient statistic for Ne(t) # "full" the tree sequence itself, as a .trees file per row # # "full" is off by default because it is not a storage trade-off, it is a # wall: measured at twenty megabases and sixty-four haplotypes a .trees # file runs 0.8 MB at an effective size of three thousand and 27.8 MB # gzipped at a hundred thousand, twenty times the sequence data it came # from. A hundred thousand rows of it would be six to eight terabytes. # It exists so a dedicated, small dataset can be generated for a genealogy # or TMRCA model later without re-running everything -- set # ``arg_detail="full"`` with a few thousand rows. # # TMRCA is not a separate setting: it is derivable from "full" and its own # per-tree form costs one to three megabytes a row, the same order as the # genotypes, for information "summary" mostly already carries. arg_detail: str = "summary" # Reproducible subset, on the same index hash as ``truth_fraction`` so it # neither consumes the noise stream nor depends on row order. arg_fraction: float = 1.0 include_truth: bool = True truth_fraction: float = 0.02 max_retries: int = 3 def apply_preset(cfg: Config) -> Config: if cfg.preset == "mini": cfg.dataset_name = "DLCoalSim-Mini" cfg.n_samples = 512 cfg.shard_size = 32 cfg.seq_len = 1_000_000 cfg.n_haplotypes = 24 cfg.time_bins = 64 cfg.workers = 1 cfg.enable_stdpopsim = False cfg.p_stdpopsim_anchor = 0.0 elif cfg.preset == "core_v01": cfg.dataset_name = "DLCoalSim-Core-v0.1" cfg.n_samples = 20_000 cfg.shard_size = 128 cfg.seq_len = 10_000_000 cfg.n_haplotypes = 64 cfg.time_bins = 64 cfg.workers = -1 cfg.p_clean_constant = 0.25 cfg.p_random_global = 0.20 cfg.p_custom_hetero = 0.35 cfg.p_empirical_slice = 0.20 cfg.p_stdpopsim_anchor = 0.0 elif cfg.preset == "full_v01": cfg.dataset_name = "DLCoalSim-Full-v0.1" cfg.n_samples = 100_000 cfg.shard_size = 128 cfg.seq_len = 20_000_000 cfg.n_haplotypes = 64 cfg.time_bins = 64 cfg.workers = -1 cfg.p_clean_constant = 0.10 cfg.p_random_global = 0.15 cfg.p_custom_hetero = 0.55 cfg.p_empirical_slice = 0.20 cfg.p_stdpopsim_anchor = 0.0 else: raise ValueError(f"Unknown preset: {cfg.preset}") return cfg def validate_config(cfg: Config) -> None: def nonempty_string(name: str) -> str: value = getattr(cfg, name) if not isinstance(value, str) or not value.strip(): raise ValueError(f"{name} must be a non-empty string") return value def integer(name: str) -> int: value = getattr(cfg, name) if isinstance(value, bool) or not isinstance(value, Integral): raise ValueError(f"{name} must be an integer") return int(value) def finite(name: str) -> float: value = getattr(cfg, name) if isinstance(value, bool) or not isinstance(value, Real): raise ValueError(f"{name} must be a finite number") result = float(value) if not math.isfinite(result): raise ValueError(f"{name} must be a finite number") return result def positive_integer(name: str) -> int: value = integer(name) if value <= 0: raise ValueError(f"{name} must be greater than 0") return value def probability_range(min_name: str, max_name: str) -> None: minimum = finite(min_name) maximum = finite(max_name) if not 0.0 <= minimum <= 1.0: raise ValueError(f"{min_name} must be between 0 and 1") if not 0.0 <= maximum <= 1.0: raise ValueError(f"{max_name} must be between 0 and 1") if minimum > maximum: raise ValueError(f"{min_name} must not exceed {max_name}") def nonnegative_range(min_name: str, max_name: str) -> None: minimum = finite(min_name) maximum = finite(max_name) if minimum < 0.0: raise ValueError(f"{min_name} must be non-negative") if maximum < 0.0: raise ValueError(f"{max_name} must be non-negative") if minimum > maximum: raise ValueError(f"{min_name} must not exceed {max_name}") def boolean(name: str) -> bool: value = getattr(cfg, name) if not isinstance(value, bool): raise ValueError(f"{name} must be a boolean") return value def weight_group(name: str, fields: tuple[str, ...]) -> float: total = 0.0 for field in fields: value = finite(field) if value < 0.0: raise ValueError(f"{field} must be non-negative") total += value if not math.isfinite(total) or total <= 0.0: raise ValueError(f"at least one {name} probability must be greater than 0") return total def empirical_ne_source_mix() -> None: text = cfg.empirical_ne_template_source_mix if not isinstance(text, str): raise ValueError("empirical_ne_template_source_mix must be a string") total = 0.0 found = False seen: set[str] = set() for raw_token in text.split(","): token = raw_token.strip() if not token: continue found = True if ":" in token: key, raw_weight = token.split(":", 1) key = key.strip() raw_weight = raw_weight.strip() if not key or not raw_weight: raise ValueError( "empirical_ne_template_source_mix entries must use 'source[:weight]'" ) try: weight = float(raw_weight) except ValueError as exc: raise ValueError( f"empirical_ne_template_source_mix has a non-numeric weight for {key!r}" ) from exc else: key = token weight = 1.0 if key not in EMPIRICAL_NE_SOURCE_KEYS: supported = ", ".join(sorted(EMPIRICAL_NE_SOURCE_KEYS)) raise ValueError( f"empirical_ne_template_source_mix contains unknown source {key!r}; " f"supported sources: {supported}" ) if key in seen: raise ValueError( f"empirical_ne_template_source_mix contains duplicate source {key!r}" ) seen.add(key) if not math.isfinite(weight) or weight < 0.0: raise ValueError( f"empirical_ne_template_source_mix weight for {key!r} must be finite and non-negative" ) total += weight if not math.isfinite(total): raise ValueError("empirical_ne_template_source_mix weights sum to a non-finite value") if not found or total <= 0.0: raise ValueError( "empirical_ne_template_source_mix must contain at least one positive source weight" ) nonempty_string("dataset_name") if cfg.preset not in {"mini", "core_v01", "full_v01"}: raise ValueError("preset must be 'mini', 'core_v01', or 'full_v01'") out_dir_text = nonempty_string("out_dir") out_dir = Path(out_dir_text).expanduser().resolve() protected_output_dirs = { Path(out_dir.anchor).resolve(), Path.home().resolve(), Path(__file__).resolve().parents[1], } if out_dir in protected_output_dirs: raise ValueError( f"out_dir must be a dedicated dataset directory, not protected path {out_dir}" ) nonempty_string("demography_mixture_version") nonempty_string("empirical_ne_template_dir") for name in ("recomb_map", "mut_map", "stdpopsim_models"): value = getattr(cfg, name) if not isinstance(value, str): raise ValueError(f"{name} must be a string") nonempty_string("stdpopsim_species") if cfg.arg_detail not in {"none", "summary", "full"}: raise ValueError("arg_detail must be 'none', 'summary', or 'full'") if not 0.0 <= cfg.arg_fraction <= 1.0: raise ValueError("arg_fraction must lie in [0, 1]") positive_integer("n_samples") positive_integer("shard_size") positive_integer("compute_chunk_size") seq_len = positive_integer("seq_len") n_haplotypes = positive_integer("n_haplotypes") positive_integer("time_bins") if n_haplotypes < 2: raise ValueError("n_haplotypes must be at least 2") if n_haplotypes % 2 != 0: raise ValueError("n_haplotypes must be even because samples are simulated as diploid individuals") if n_haplotypes > INT16_MAX: raise ValueError(f"n_haplotypes must not exceed the int16 storage limit ({INT16_MAX})") packed_hap_bytes = math.ceil(n_haplotypes / 8) if packed_hap_bytes > INT16_MAX: raise ValueError(f"packed haplotype width must not exceed the int16 storage limit ({INT16_MAX})") if seq_len > UINT32_MAX: raise ValueError(f"seq_len must not exceed the uint32 position limit ({UINT32_MAX})") # There is no bound on ``seq_len * n_haplotypes`` here. The sparse missing # index addresses the (variants, haplotypes) matrix, not the (bases, # haplotypes) one, and variants are three orders of magnitude rarer than # bases -- the old check rejected 60 Mb at 64 haplotypes, which stores an # index reaching about one billion. The width is chosen per row from the # matrix actually built and declared in ``missing_storage``. resolution = finite("demography_resolution_log10") if resolution <= 0.0: raise ValueError("demography_resolution_log10 must be greater than 0") min_time = finite("min_time") max_time = finite("max_time") if min_time <= 0.0: raise ValueError("min_time must be greater than 0") if max_time <= min_time: raise ValueError("max_time must be greater than min_time") for name in ("baseline_mu", "baseline_rec"): value = finite(name) if value <= 0.0: raise ValueError(f"{name} must be greater than 0") if value < FLOAT32_MIN_POSITIVE: raise ValueError(f"{name} is too small to remain positive in float32 storage") if value > MAX_BASELINE_RATE: raise ValueError( f"{name} must not exceed {MAX_BASELINE_RATE:g} per bp per generation " "because synthetic maps can amplify a baseline rate by up to " f"{MAX_SYNTHETIC_RATE_MULTIPLIER:g}x" ) if value > FLOAT32_MAX: raise ValueError(f"{name} exceeds the float32 storage limit") for name in ( "force", "compression", "include_truth", "enable_stdpopsim", "mut_map_scale_to_baseline", ): boolean(name) weight_group("source", SOURCE_PROB_FIELDS) enabled_source_total = sum( finite(name) for name in SOURCE_PROB_FIELDS if name != "p_stdpopsim_anchor" ) if cfg.enable_stdpopsim: enabled_source_total += finite("p_stdpopsim_anchor") if enabled_source_total <= 0.0: raise ValueError("at least one enabled source probability must be greater than 0") weight_group("demography", DEMOGRAPHY_PROB_FIELDS) empirical_ne_source_mix() probability_range("genotype_error_min", "genotype_error_max") probability_range("missing_rate_min", "missing_rate_max") if not 0.0 <= float(cfg.truth_fraction) <= 1.0: raise ValueError("truth_fraction must lie in [0, 1]") probability_range("phase_switch_rate_per_het_min", "phase_switch_rate_per_het_max") hotspot_missing_prob = finite("hotspot_missing_prob") if not 0.0 <= hotspot_missing_prob <= 1.0: raise ValueError("hotspot_missing_prob must be between 0 and 1") for name in ( "observed_map_noise", "empirical_ne_template_log10_shift_sd", "empirical_ne_template_contrast_sd", "empirical_ne_template_time_warp_sd", "empirical_ne_template_bin_noise_sd", ): if finite(name) < 0.0: raise ValueError(f"{name} must be non-negative") map_segments_min = positive_integer("map_segments_min") map_segments_max = positive_integer("map_segments_max") if map_segments_min > map_segments_max: raise ValueError("map_segments_min must not exceed map_segments_max") max_retries = integer("max_retries") if max_retries < 1: raise ValueError("max_retries must be at least 1") workers = integer("workers") if workers != -1 and workers < 1: raise ValueError("workers must be -1 or an integer greater than 0") compression_level = integer("compression_level") if not 0 <= compression_level <= 9: raise ValueError("compression_level must be between 0 and 9") integer("seed") stdpopsim_contig_length = integer("stdpopsim_contig_length") if stdpopsim_contig_length < 0: raise ValueError("stdpopsim_contig_length must be 0 or greater") if stdpopsim_contig_length > UINT32_MAX: raise ValueError(f"stdpopsim_contig_length must not exceed the uint32 position limit ({UINT32_MAX})") if cfg.recomb_map_unit not in {"per_bp", "cM_per_Mb"}: raise ValueError("recomb_map_unit must be 'per_bp' or 'cM_per_Mb'") if cfg.mut_map_unit not in {"per_bp", "relative", "roulette_raw"}: raise ValueError("mut_map_unit must be 'per_bp', 'relative', or 'roulette_raw'")