from __future__ import annotations import csv import hashlib import re from dataclasses import dataclass from pathlib import Path import numpy as np from .assets import asset_path from .config import Config @dataclass(frozen=True) class NeTemplate: source_key: str method: str population: str generations_ago: np.ndarray ne: np.ndarray path: str time_unit_note: str @dataclass class EmpiricalNeTemplateStore: templates: list[NeTemplate] source_counts: dict[str, int] def choose(self, rng: np.random.Generator, cfg: Config) -> NeTemplate: weights = _parse_source_mix(cfg.empirical_ne_template_source_mix) available = [key for key in weights if self.source_counts.get(key, 0) > 0 and weights[key] > 0] if not available: available = [key for key, count in self.source_counts.items() if count > 0] if not available: raise RuntimeError("no empirical Ne templates are available") p = np.asarray([weights.get(key, 1.0) for key in available], dtype=np.float64) source_key = str(rng.choice(available, p=p / p.sum())) choices = [t for t in self.templates if t.source_key == source_key] return choices[int(rng.integers(0, len(choices)))] _STORE_CACHE: dict[str, EmpiricalNeTemplateStore] = {} def empirical_ne_templates_available(cfg: Config) -> bool: return len(load_empirical_ne_templates(cfg).templates) > 0 def empirical_ne_template_provenance( cfg: Config, *, include_source_files: bool = True, ) -> dict: """Fingerprint the exact parsed template curves and their source files.""" store = load_empirical_ne_templates(cfg) digest = hashlib.sha256() ordered = sorted( store.templates, key=lambda template: ( template.source_key, template.method, template.population, template.path, ), ) def update_text(value: str) -> None: encoded = value.encode("utf-8") digest.update(len(encoded).to_bytes(8, "little")) digest.update(encoded) for template in ordered: for value in ( template.source_key, template.method, template.population, template.time_unit_note, ): update_text(value) for array in (template.generations_ago, template.ne): values = np.asarray(array, dtype=" EmpiricalNeTemplateStore: root = _resolve_template_dir(cfg.empirical_ne_template_dir) key = str(root.resolve()) if root.exists() else str(root) cached = _STORE_CACHE.get(key) if cached is not None: return cached templates: list[NeTemplate] = [] templates.extend(_load_smcpp_1kg(root / "smcpp_popsizes_1kg.csv")) templates.extend( _load_normalized( root / "phlash_unified_populations_normalized.csv", source_key="phlash_unified", method="PHLaSH", time_unit_note="generations; normalized from phlash_paper fig7a", ) ) if not any(t.source_key == "phlash_unified" for t in templates): templates.extend( _load_phlash_raw( root / "phlash_fig7a_unified_populations.csv", source_key="phlash_unified", method="PHLaSH", ) ) templates.extend( _load_normalized( root / "phlash_superpopulations_normalized.csv", source_key="phlash_super", method="PHLaSH", time_unit_note="generations; normalized from phlash_paper fig7b", ) ) if not any(t.source_key == "phlash_super" for t in templates): templates.extend( _load_phlash_raw( root / "phlash_fig7b_superpopulations.csv", source_key="phlash_super", method="PHLaSH", ) ) templates.extend( _load_normalized( root / "msmc2_yoruba_french_within_ne_normalized.csv", source_key="msmc2_example", method="MSMC2", time_unit_note="generations; converted from MSMC2 scaled time using mu=1.25e-8", ) ) templates.extend( _load_normalized( root / "msmc_im_yoruba_french_ne_normalized.csv", source_key="msmc_im_example", method="MSMC-IM", time_unit_note="generations; MSMC-IM example output", ) ) counts: dict[str, int] = {} for template in templates: counts[template.source_key] = counts.get(template.source_key, 0) + 1 store = EmpiricalNeTemplateStore(templates=templates, source_counts=counts) _STORE_CACHE[key] = store return store def _resolve_template_dir(path: str) -> Path: return asset_path(path) def _parse_source_mix(text: str) -> dict[str, float]: out: dict[str, float] = {} for token in text.split(","): token = token.strip() if not token: continue if ":" in token: key, value = token.split(":", 1) out[key.strip()] = max(0.0, float(value)) else: out[token] = 1.0 return out def _read_csv(path: Path) -> list[dict[str, str]]: if not path.exists(): return [] with path.open("r", encoding="utf-8", newline="") as f: return list(csv.DictReader(f)) def _load_smcpp_1kg(path: Path) -> list[NeTemplate]: rows = _read_csv(path) if not rows: return [] grouped: dict[str, list[tuple[float, float]]] = {} for row in rows: if row.get("plot_type", "path") != "path": continue pop = row["label"] generations = float(row["x"]) / 29.0 grouped.setdefault(pop, []).append((generations, float(row["y"]))) return _templates_from_groups( grouped, source_key="smcpp_1kg", method="SMC++", path=path, time_unit_note="years converted to generations using generation_time=29", ) def _load_normalized(path: Path, source_key: str, method: str, time_unit_note: str) -> list[NeTemplate]: rows = _read_csv(path) if not rows: return [] grouped: dict[str, list[tuple[float, float]]] = {} for row in rows: pop = row["population"] grouped.setdefault(pop, []).append((float(row["generations_ago"]), float(row["Ne"]))) return _templates_from_groups(grouped, source_key, method, path, time_unit_note) def _load_phlash_raw(path: Path, source_key: str, method: str) -> list[NeTemplate]: rows = _read_csv(path) if not rows: return [] grouped: dict[str, list[tuple[float, float]]] = {} for row in rows: pop = _clean_phlash_population(row["pop"]) grouped.setdefault(pop, []).append((float(row["years"]), float(row["Ne"]))) return _templates_from_groups( grouped, source_key=source_key, method=method, path=path, time_unit_note="generations; phlash_paper CSV column is named years but generated from T in generations", ) def _clean_phlash_population(value: str) -> str: match = re.search(r"unified/(.*?)/phlash/estimates\.pkl", value) return match.group(1) if match else value def _templates_from_groups( grouped: dict[str, list[tuple[float, float]]], source_key: str, method: str, path: Path, time_unit_note: str, ) -> list[NeTemplate]: out: list[NeTemplate] = [] for pop, pairs in grouped.items(): arr = np.asarray(sorted(pairs), dtype=np.float64) arr = arr[np.isfinite(arr).all(axis=1)] arr = arr[(arr[:, 0] >= 0) & (arr[:, 1] > 0)] if arr.shape[0] < 2: continue _, unique_idx = np.unique(arr[:, 0], return_index=True) arr = arr[np.sort(unique_idx)] out.append( NeTemplate( source_key=source_key, method=method, population=pop, generations_ago=arr[:, 0].astype(np.float64), ne=arr[:, 1].astype(np.float64), path=str(path), time_unit_note=time_unit_note, ) ) return out