from __future__ import annotations import numpy as np import pytest import simulator.empirical_maps as empirical_maps_module from simulator.config import Config from simulator.empirical_maps import ( EmpiricalMapStore, PiecewiseRateMap, load_empirical_rate_table, slice_piecewise_map, ) from simulator.maps import sample_maps_for_source def _rate_map(chrom: str, positions: list[float], rates: list[float]) -> PiecewiseRateMap: return PiecewiseRateMap( chrom=chrom, position=np.asarray(positions, dtype=np.float64), rate=np.asarray(rates, dtype=np.float64), ) def test_common_chroms_require_a_shared_coordinate_span() -> None: store = EmpiricalMapStore( rec_maps={"chr1": _rate_map("chr1", [100, 250, 400], [1e-8, 2e-8])}, mut_maps={"chr1": _rate_map("chr1", [120, 300, 500], [3e-8, 4e-8])}, ) assert store.common_slice_start_bounds("chr1", 280) == (120.0, 120.0) assert store.common_chroms(280) == ["chr1"] assert store.common_chroms(281) == [] def test_slice_piecewise_map_accepts_an_explicit_start_and_exact_end_boundary() -> None: rate_map = _rate_map("chr1", [100, 150, 250, 400], [1e-8, 2e-8, 3e-8]) pos, true_rate, obs_pos, _, meta = slice_piecewise_map( np.random.default_rng(1), rate_map, length=100, obs_noise_sigma=0.0, baseline_rate=1e-8, start=150, ) np.testing.assert_array_equal(pos, [0.0, 100.0]) np.testing.assert_array_equal(obs_pos, pos) np.testing.assert_array_equal(true_rate, [2e-8]) assert meta["slice_start_bp"] == 150.0 assert meta["slice_end_bp"] == 250.0 def test_empirical_source_uses_one_colocated_interval_for_both_maps() -> None: cfg = Config(seq_len=100, baseline_rec=1e-8, baseline_mu=1e-8, observed_map_noise=0.0) store = EmpiricalMapStore( rec_maps={"chr1": _rate_map("chr1", [100, 200, 300, 400], [1e-8, 2e-8, 3e-8])}, mut_maps={"chr1": _rate_map("chr1", [120, 220, 320, 420], [4e-8, 5e-8, 6e-8])}, ) *_, meta = sample_maps_for_source( np.random.default_rng(7), cfg, "empirical_map_slice", store, ) rec_meta = meta["rec_slice"] mut_meta = meta["mut_slice"] assert meta["slice_alignment"] == "shared_chromosomal_interval" assert meta["slice_chrom"] == rec_meta["chrom"] == mut_meta["chrom"] == "chr1" assert meta["slice_start_bp"] == rec_meta["slice_start_bp"] == mut_meta["slice_start_bp"] assert meta["slice_end_bp"] == rec_meta["slice_end_bp"] == mut_meta["slice_end_bp"] assert meta["slice_end_bp"] - meta["slice_start_bp"] == pytest.approx(cfg.seq_len) assert 120.0 <= meta["slice_start_bp"] <= 300.0 def test_explicit_start_must_fit_inside_the_source_map() -> None: rate_map = _rate_map("chr1", [100, 200, 300], [1e-8, 2e-8]) with pytest.raises(ValueError, match="outside the valid range"): slice_piecewise_map( np.random.default_rng(1), rate_map, length=100, obs_noise_sigma=0.0, baseline_rate=1e-8, start=201, ) def test_non_finite_empirical_coordinates_are_rejected(tmp_path) -> None: path = tmp_path / "invalid-map.bed" path.write_text( "chr1 0 100 1e-8\n" "chr1 100 inf 2e-8\n", encoding="utf-8", ) with pytest.raises(ValueError, match="non-finite"): load_empirical_rate_table( str(path), baseline_rate=1e-8, map_kind="recombination", ) def test_non_finite_manual_rate_map_is_rejected_before_slicing() -> None: rate_map = _rate_map("chr1", [0.0, 100.0], [float("inf")]) with pytest.raises(ValueError, match="non-finite"): slice_piecewise_map( np.random.default_rng(1), rate_map, length=50, obs_noise_sigma=0.0, baseline_rate=1e-8, ) def test_common_span_validation_is_cached_off_the_sample_hot_path( monkeypatch: pytest.MonkeyPatch, ) -> None: store = EmpiricalMapStore( rec_maps={"chr1": _rate_map("chr1", [0, 100, 200], [1e-8, 2e-8])}, mut_maps={"chr1": _rate_map("chr1", [0, 120, 220], [3e-8, 4e-8])}, ) original = empirical_maps_module._validate_piecewise_rate_map calls = 0 def counted(rate_map: PiecewiseRateMap) -> None: nonlocal calls calls += 1 original(rate_map) monkeypatch.setattr(empirical_maps_module, "_validate_piecewise_rate_map", counted) assert store.is_available(100) assert store.is_available(100) assert store.common_chroms(100) == ["chr1"] assert store.common_slice_start_bounds("chr1", 100) == (0.0, 100.0) assert calls == 2 cfg = Config(seq_len=100, observed_map_noise=0.0) sample_maps_for_source(np.random.default_rng(3), cfg, "empirical_map_slice", store) sample_maps_for_source(np.random.default_rng(4), cfg, "empirical_map_slice", store) assert calls == 2