id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
286,487,579
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ncc1Cl
Cl.Cl.NCc1ncccc1F
O=C(N[Dy])[C@@H]1Cc2ccccc2CN1c1nc(NCc2ncccc2F)nc(Nc2nc(Cl)ncc2Cl)n1
sEH
0
238,618,282
O=C(O)CC1(NC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
CC(=O)c1cccc(N)c1
Nc1nc(F)nc2nc[nH]c12
CC(=O)c1cccc(Nc2nc(Nc3nc(F)nc4nc[nH]c34)nc(NC3(CC(=O)N[Dy])CCCCC3)n2)c1
HSA
0
241,224,311
O=C(O)COC[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1sc(N)c(C#N)c1C
Cl.Cl.NCC1(c2ccncc2)CC1
Cc1sc(Nc2nc(NCC3(c4ccncc4)CC3)nc(N3CCC[C@@H]3COCC(=O)N[Dy])n2)c(C#N)c1C
sEH
0
39,705,663
COc1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O
Cl.Cl.NCCn1cnc2ccsc2c1=O
Cl.Cn1cc(N)ccc1=O
COc1cccc(Nc2nc(NCCn3cnc4ccsc4c3=O)nc(Nc3ccc(=O)n(C)c3)n2)c1C(=O)N[Dy]
BRD4
0
8,378,872
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC1CCC(C(F)F)CC1
Nc1ccc2c(c1)COC2=O
C=CCC[C@@H](Nc1nc(NCC2CCC(C(F)F)CC2)nc(Nc2ccc3c(c2)COC3=O)n1)C(=O)N[Dy]
HSA
0
157,246,726
O=C(Nc1cc(Br)c(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1O
Cl.Cl.NCc1nc2c(F)c(F)ccc2[nH]1
Cc1cc(Nc2nc(NCc3nc4c(F)c(F)ccc4[nH]3)nc(Nc3cc(Br)c(Cl)cc3C(=O)N[Dy])n2)ccc1O
HSA
0
81,773,643
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(O)(CN)CN1CCOCC1
NCCOc1cccnc1
CC(O)(CNc1nc(NCCOc2cccnc2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)CN1CCOCC1
BRD4
0
249,520,318
O=C(O)C[C@@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CC(C)(C)OC(=O)n1ncc2cc(N)ccc21
Cl.NCc1cc(C(F)(F)F)co1
CC(C)(C)OC(=O)n1ncc2cc(Nc3nc(NCc4cc(C(F)(F)F)co4)nc(N[C@@H](CC(=O)N[Dy])Cc4ccc(I)cc4)n3)ccc21
HSA
0
182,608,845
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nc2ccccc2o1
COC(=O)c1occc1N
COC(=O)c1occc1Nc1nc(NCc2nc3ccccc3o2)nc(Nc2ccc(C(=O)N[Dy])c(C(=O)O)c2)n1
BRD4
0
128,304,706
O=C(N[C@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1c2ccccc2nc2ccccc12
CN(CC(F)(F)F)C(=O)CN.Cl
CN(CC(F)(F)F)C(=O)CNc1nc(Nc2c3ccccc3nc3ccccc23)nc(N[C@H](Cc2csc3ccccc23)C(=O)N[Dy])n1
HSA
0
61,467,580
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.Cn1cncc1CN
CN(C)c1cccnc1CN
Cc1ccccc1[C@@H](CC(=O)N[Dy])Nc1nc(NCc2ncccc2N(C)C)nc(NCc2cncn2C)n1
HSA
0
248,235,953
O=C(O)C[C@@H](Cc1ccc(Cl)cc1Cl)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)cc1
Nc1cc(F)ccn1
O=C(C[C@@H](Cc1ccc(Cl)cc1Cl)Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(Nc2cc(F)ccn2)n1)N[Dy]
sEH
0
78,166,842
O=C(NC1(C(=O)O)CCCC1)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)n1
CCOc1ccnc(N)c1
CCOc1ccnc(Nc2nc(NCc3cccc(C(F)(F)F)n3)nc(NC3(C(=O)N[Dy])CCCC3)n2)c1
BRD4
0
112,660,552
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
Cc1sc(C)c(CN)c1Br.Cl
Cl.Cl.NCC(O)c1ccncc1
Cc1sc(C)c(CNc2nc(NCC(O)c3ccncc3)nc(N[C@H](C(=O)N[Dy])C3CCCC3)n2)c1Br
HSA
0
62,776,377
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Cl.NCc1noc2ccc(F)cc12
C[Si](C)(C)C#Cc1ccc(N)cn1
Cn1cc(C[C@@H](Nc2nc(NCc3noc4ccc(F)cc34)nc(Nc3ccc(C#C[Si](C)(C)C)nc3)n2)C(=O)N[Dy])c2ccccc21
BRD4
0
249,106,129
O=C(O)C[C@@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
N#Cc1ccc(N)c([N+](=O)[O-])c1
Nc1ccc(F)cc1Cl
N#Cc1ccc(Nc2nc(Nc3ccc(F)cc3Cl)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(F)cc3)n2)c([N+](=O)[O-])c1
HSA
0
54,081,336
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cn1nccc1CN1C[C@@H](F)C[C@H]1CN
Cn1ccc(N)n1
Cc1ccc(C(=O)N[Dy])c(Nc2nc(NC[C@@H]3C[C@H](F)CN3Cc3ccnn3C)nc(Nc3ccn(C)n3)n2)c1C
BRD4
0
189,329,077
O=C(Nc1ccc(C(=O)O)cc1C(F)(F)F)OCC1c2ccccc2-c2ccccc21
Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Cl.NCC1Cc2ccccc2NC1=O
O=C(N[Dy])c1ccc(Nc2nc(NCC3Cc4ccccc4NC3=O)nc(Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)c(C(F)(F)F)c1
HSA
0
52,207,123
Cc1cc(C)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Nc1cccnc1F
Cc1nc(Cl)c(N)c(Cl)n1
Cc1cc(C)c(Nc2nc(Nc3cccnc3F)nc(Nc3c(Cl)nc(C)nc3Cl)n2)c(C(=O)N[Dy])c1
HSA
0
93,551,429
O=C(N[C@@H](Cc1ccc(Br)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)C(O)CCC2
Cn1cc(N)cn1
Cn1cc(Nc2nc(Nc3ccc4c(c3)C(O)CCC4)nc(N[C@@H](Cc3ccc(Br)cc3)C(=O)N[Dy])n2)cn1
sEH
0
96,284,769
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
CCS(=O)(=O)N1CC(CN)C1.Cl
CCS(=O)(=O)N1CC(CNc2nc(Nc3cnccc3C)nc(N[C@@H](Cc3ccc(Cl)cc3Cl)C(=O)N[Dy])n2)C1
BRD4
0
10,297,017
C=CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1cc2n(n1)CCCO2
COc1ccccc1-c1nnc(N)s1
C=CC[C@H](Nc1nc(NCc2cc3n(n2)CCCO3)nc(Nc2nnc(-c3ccccc3OC)s2)n1)C(=O)N[Dy]
BRD4
0
151,616,364
O=C(Nc1c(F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(OC)c(OC)cc1N
Nc1cc[nH]c(=O)c1
COC(=O)c1cc(OC)c(OC)cc1Nc1nc(Nc2cc[nH]c(=O)c2)nc(Nc2c(F)cccc2C(=O)N[Dy])n1
BRD4
0
199,938,998
O=C(Nc1ccc(Cl)nc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC2(C1)CC2(F)F
CC(CN)Cn1cccn1
CC(CNc1nc(NCC2CC3(C2)CC3(F)F)nc(Nc2ccc(Cl)nc2C(=O)N[Dy])n1)Cn1cccn1
sEH
0
245,195,972
O=C(O)C[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
CC1(C)CC(CCN)C(=O)N1.Cl
Nc1ccc2c(c1)C(=O)CCC2
CC1(C)CC(CCNc2nc(Nc3ccc4c(c3)C(=O)CCC4)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(Cl)c(Cl)c3)n2)C(=O)N1
sEH
0
67,928,215
N#Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cc1cc(N)on1
CCN1CCN(Cc2ccc(N)nc2)CC1
CCN1CCN(Cc2ccc(Nc3nc(Nc4cc(C)no4)nc(Nc4ccc(C#N)cc4C(=O)N[Dy])n3)nc2)CC1
HSA
0
166,310,791
O=C(Nc1cc(C(=O)O)ccc1C(F)(F)F)OCC1c2ccccc2-c2ccccc21
N#Cc1ccccc1N
COC(=O)c1nc(N)sc1Br
COC(=O)c1nc(Nc2nc(Nc3ccccc3C#N)nc(Nc3cc(C(=O)N[Dy])ccc3C(F)(F)F)n2)sc1Br
HSA
0
222,086,629
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1
COc1nc(C)nc(N)n1
COc1nc(C)nc(Nc2nc(Nc3ccc(N4CCC=C(N5CCOCC5)C4=O)cc3)nc(Nc3cnccc3C(=O)N[Dy])n2)n1
HSA
0
9,100,708
C=CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1cc([N+](=O)[O-])c(Cl)cc1N
Nc1nc2ccccc2s1
C=CC[C@@H](Nc1nc(Nc2nc3ccccc3s2)nc(Nc2cc(Cl)c([N+](=O)[O-])cc2C)n1)C(=O)N[Dy]
HSA
0
8,311,303
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cn1cc(C2(CN)CCCO2)cn1
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
C=CCC[C@@H](Nc1nc(NCc2cn([C@@H]3COC[C@H]3OC)nn2)nc(NCC2(c3cnn(C)c3)CCCO2)n1)C(=O)N[Dy]
HSA
0
281,035,763
O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ccc1Cl
CCn1cc(N)c(C)n1
CCn1cc(Nc2nc(Nc3nc(Cl)ccc3Cl)nc(N3CCC[C@H]3C(=O)N[Dy])n2)c(C)n1
sEH
0
31,250,363
COc1cc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)cn1
NCC1(OCCO)CCC1
Nc1nc(Cl)c(C=O)c(Cl)n1
COc1cc(C(=O)N[Dy])c(Nc2nc(NCC3(OCCO)CCC3)nc(Nc3nc(Cl)c(C=O)c(Cl)n3)n2)cn1
sEH
0
255,880,301
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1ccc([N+](=O)[O-])cn1
Cl.NCCC1CN(c2ncnc3[nH]ncc23)c2ccccc21
O=C(C[C@@H](Nc1nc(NCCC2CN(c3ncnc4[nH]ncc34)c3ccccc32)nc(Nc2ccc([N+](=O)[O-])cn2)n1)c1ccc(Br)cc1)N[Dy]
sEH
0
129,307,890
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
NCC1CCCCC(F)(F)C1
COC(=O)c1occc1N
COC(=O)c1occc1Nc1nc(NCC2CCCCC(F)(F)C2)nc(N[C@H]2C=C[C@@H](C(=O)N[Dy])C2)n1
BRD4
0
111,308,337
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1OC
Cn1ncc2cc(N)ccc21
COC(=O)c1ccc(Nc2nc(Nc3ccc4c(cnn4C)c3)nc(N[C@H](C(=O)N[Dy])C3CC3)n2)cc1OC
BRD4
0
6,253,546
C=CCC(CC=C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cc(F)cc(F)c1
Cc1cc(N)n[nH]1
C=CCC(CC=C)(Nc1nc(NCc2cc(F)cc(F)c2)nc(Nc2cc(C)[nH]n2)n1)C(=O)N[Dy]
HSA
0
167,707,195
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1cnc(Cl)cc1Cl
Cl.NCC(F)(F)C1CC1
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCC(F)(F)C3CC3)nc(Nc3cnc(Cl)cc3Cl)n2)c1
HSA
0
39,239,426
COc1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O
CC(=O)Nc1cccc(N)n1
Cl.Cl.NCC1CCN(CC(F)F)CC1
COc1cccc(Nc2nc(NCC3CCN(CC(F)F)CC3)nc(Nc3cccc(NC(C)=O)n3)n2)c1C(=O)N[Dy]
sEH
0
204,087,970
O=C(Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1cc(F)ccc1N
Cl.Cl.NCC(O)c1ccncc1
Cc1cc(F)ccc1Nc1nc(NCC(O)c2ccncc2)nc(Nc2ccc([N+](=O)[O-])c(C(=O)N[Dy])c2)n1
HSA
0
129,073,212
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ncccc1F
Br.Br.NCC1CCCN1c1cccnn1
O=C(N[Dy])[C@@H]1C=C[C@H](Nc2nc(NCc3ncccc3F)nc(NCC3CCCN3c3cccnn3)n2)C1
BRD4
0
67,852,530
N#Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
COc1ncccc1N
Cl.NCc1noc2ccc(F)cc12
COc1ncccc1Nc1nc(NCc2noc3ccc(F)cc23)nc(Nc2ccc(C#N)cc2C(=O)N[Dy])n1
BRD4
0
97,957,669
O=C(N[C@@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccccc1-c1nnn[nH]1
Cl.Cl.NCc1ncccc1F
O=C(N[Dy])[C@H](Cc1ccc(F)c(F)c1)Nc1nc(NCc2ncccc2F)nc(Nc2ccccc2-c2nnn[nH]2)n1
HSA
0
163,824,386
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
Cc1cccc2oc(CCN)nc12.Cl.Cl
NCC1(c2ccc(Cl)cc2Cl)CCCC1
Cc1cccc2oc(CCNc3nc(NCC4(c5ccc(Cl)cc5Cl)CCCC4)nc(Nc4cc(C(=O)N[Dy])ccc4Br)n3)nc12
sEH
0
185,765,605
O=C(Nc1ccc(C(=O)O)c(F)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(F)CCOC1
Nc1ncc(F)cc1[N+](=O)[O-]
O=C(N[Dy])c1ccc(Nc2nc(NCC3(F)CCOC3)nc(Nc3ncc(F)cc3[N+](=O)[O-])n2)cc1F
HSA
0
255,483,031
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Cl.NCC(F)(F)C1CC1
CCOC(=O)c1cnn(C)c1N
CCOC(=O)c1cnn(C)c1Nc1nc(NCC(F)(F)C2CC2)nc(N[C@H](CC(=O)N[Dy])c2ccc(Br)cc2)n1
HSA
0
61,711,420
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
N#Cc1c(N)cccc1F
Nc1ncnc2[nH]cnc12
Cc1ccccc1[C@@H](CC(=O)N[Dy])Nc1nc(Nc2cccc(F)c2C#N)nc(Nc2ncnc3[nH]cnc23)n1
HSA
0
166,408,486
O=C(Nc1cc(C(=O)O)ccc1C(F)(F)F)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)c1
Cl.NCC1CCCOC1
O=C(N[Dy])c1ccc(C(F)(F)F)c(Nc2nc(NCc3cccc(C(F)(F)F)c3)nc(NCC3CCCOC3)n2)c1
HSA
0
164,810,437
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ncc(N)cn1
Nc1nc2cc(Br)ccn2n1
COc1ncc(Nc2nc(Nc3nc4cc(Br)ccn4n3)nc(Nc3cc(C(=O)N[Dy])ccc3C(=O)O)n2)cn1
HSA
0
86,569,201
O=C(N[C@@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cn[nH]c1
Nc1ncnc2c1ncn2C1CCCCO1
O=C(N[Dy])[C@H](Nc1nc(NCc2cn[nH]c2)nc(Nc2ncnc3c2ncn3C2CCCCO2)n1)C1CCCCC1
HSA
0
146,837,252
O=C(Nc1c(Cl)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
CC(C)NC(=O)NCCN.Cl.Cl
CC(C)NC(=O)NCCNc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(Nc2c(Cl)cc(F)cc2C(=O)N[Dy])n1
sEH
0
17,775,134
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1cc(C)c(CN)c(=O)[nH]1.Cl
Nc1n[nH]c2ncccc12
Cc1cc(C)c(CNc2nc(Nc3n[nH]c4ncccc34)nc(NC(CC(C)C)C(=O)N[Dy])n2)c(=O)[nH]1
sEH
0
116,313,053
O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cnn(Cc2ccccc2)c1
Cl.NCC(=O)NC1CCC1
O=C(CNc1nc(NCc2cnn(Cc3ccccc3)c2)nc(N[C@H](CC2CCCC2)C(=O)N[Dy])n1)NC1CCC1
sEH
0
111,408,160
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
COc1ccnc(N)n1
NCc1ccc(NC(=O)c2ccco2)cc1
COc1ccnc(Nc2nc(NCc3ccc(NC(=O)c4ccco4)cc3)nc(N[C@H](C(=O)N[Dy])C3CC3)n2)n1
HSA
0
185,530,535
O=C(Nc1ccc(C(=O)O)c(F)c1)OCC1c2ccccc2-c2ccccc21
CSC1(CN)CCOCC1.Cl
COc1ccc(N)c(Cl)c1
COc1ccc(Nc2nc(NCC3(SC)CCOCC3)nc(Nc3ccc(C(=O)N[Dy])c(F)c3)n2)c(Cl)c1
sEH
0
277,727,444
O=C(O)C[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1F
Nc1nccc(Cl)n1
O=C(C[C@H]1Cc2ccccc2CN1c1nc(Nc2nccc(Cl)n2)nc(Nc2cccnc2F)n1)N[Dy]
sEH
0
143,433,807
O=C(Nc1c(C(=O)O)sc2ncccc12)OCC1c2ccccc2-c2ccccc21
N#Cc1ccnc(N)c1
Nc1ccc(Cl)cn1
N#Cc1ccnc(Nc2nc(Nc3ccc(Cl)cn3)nc(Nc3c(C(=O)N[Dy])sc4ncccc34)n2)c1
BRD4
0
239,082,243
O=C(O)CC1(NC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
Cl.Cl.NCc1cc(Br)cc2cccnc12
CCn1cc2cc(N)ccc2n1
CCn1cc2cc(Nc3nc(NCc4cc(Br)cc5cccnc45)nc(NC4(CC(=O)N[Dy])CCCCC4)n3)ccc2n1
BRD4
0
104,238,972
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1(O)CCSC1
Cc1cc(N)ncn1
Cc1cc(Nc2nc(NCC3(O)CCSC3)nc(N[C@@H](Cc3cccnc3)C(=O)N[Dy])n2)ncn1
BRD4
0
191,176,821
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1nc2cnccc2s1
NCc1cn(C(F)F)c2ccccc12
O=C(N[Dy])c1ccc(Nc2nc(NCc3nc4cnccc4s3)nc(NCc3cn(C(F)F)c4ccccc34)n2)c(F)c1
BRD4
0
264,239,461
O=C(O)C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCC1CN(c2ncnc3[nH]ncc23)c2ccccc21
Cl.NCC1C=CCC1
O=C(C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)Nc1nc(NCCC2CN(c3ncnc4[nH]ncc34)c3ccccc32)nc(NCC2C=CCC2)n1)N[Dy]
HSA
0
213,018,458
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCC2(CCC2)CO1
Nc1nc2c(s1)COCC2
O=C(N[Dy])c1c(F)cccc1Nc1nc(NCC2CCC3(CCC3)CO2)nc(Nc2nc3c(s2)COCC3)n1
sEH
0
269,417,979
O=C(O)C[C@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CSC1(CN)CCOCC1.Cl
Nc1nc2ccccc2o1
CSC1(CNc2nc(Nc3nc4ccccc4o3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(F)cc3)n2)CCOCC1
BRD4
0
22,706,608
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
Nc1ccc(F)nc1
Nc1ccc(Cl)nc1
CCOc1cc(Nc2nc(Nc3ccc(F)nc3)nc(Nc3ccc(Cl)nc3)n2)c(Cl)cc1C(=O)N[Dy]
HSA
0
53,144,651
Cc1cc(Cl)cc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(CO)ccn1
NCc1cc2c(s1)CCSC2
Cc1cc(Cl)cc(C(=O)N[Dy])c1Nc1nc(NCc2cc3c(s2)CCSC3)nc(Nc2cc(CO)ccn2)n1
sEH
0
206,322,049
O=C(Nc1ccc2cc(C(=O)O)ccc2c1)OCC1c2ccccc2-c2ccccc21
Cc1ccccc1-n1nc(C)c(CN)c1C.Cl.Cl
Cc1nc(CCN)sc1C
Cc1ccccc1-n1nc(C)c(CNc2nc(NCCc3nc(C)c(C)s3)nc(Nc3ccc4cc(C(=O)N[Dy])ccc4c3)n2)c1C
HSA
0
28,695,236
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)n(-c2ccccc2)n1
NCc1ccc(C(=O)N2CCCC2)cc1
COc1c(F)ccc(C(=O)N[Dy])c1Nc1nc(NCc2ccc(C(=O)N3CCCC3)cc2)nc(Nc2cc(C)nn2-c2ccccc2)n1
sEH
0
243,462,672
O=C(O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1nc2cnccc2s1
CCOC(=O)c1sc(N)nc1C
CCOC(=O)c1sc(Nc2nc(NCc3nc4cnccc4s3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(Br)cc3)n2)nc1C
BRD4
0
217,467,152
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cocn1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCc4cocn4)nc(Nc4cccnc4C(=O)N[Dy])n3)ccc2[nH]1
sEH
0
131,198,190
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(C(N)=O)C1
Cl.NCc1nnc2ncccn12
NC(=O)N1CCC(CNc2nc(NCc3nnc4ncccn34)nc(N[C@H]3CC[C@@H](C(=O)N[Dy])C3)n2)C1
BRD4
0
191,101,816
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cc1nccn1-c1ncccc1CN
Cl.NCc1ccc[nH]c1=O
Cc1nccn1-c1ncccc1CNc1nc(NCc2ccc[nH]c2=O)nc(Nc2ccc(C(=O)N[Dy])cc2F)n1
HSA
0
155,422,705
O=C(Nc1c(OC(F)(F)F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1ncc(N)cc1C(F)(F)F
NCc1ccc2[nH]ccc2c1
N#Cc1ncc(Nc2nc(NCc3ccc4[nH]ccc4c3)nc(Nc3c(OC(F)(F)F)cccc3C(=O)N[Dy])n2)cc1C(F)(F)F
HSA
0
1,452,592
C#CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1cc(N)ccc1Cl
COc1ncc(N)cn1
C#CC[C@@H](Nc1nc(Nc2cnc(OC)nc2)nc(Nc2ccc(Cl)c(C)c2)n1)C(=O)N[Dy]
HSA
0
136,706,201
O=C(Nc1c(C(=O)O)cc(Cl)c(Br)c1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1nnc2n1CCOCC2
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
O=C(N[Dy])c1cc(Cl)c(Br)c(F)c1Nc1nc(NCc2nnc3n2CCOCC3)nc(Nc2n[nH]c3c(Cl)cc([N+](=O)[O-])cc23)n1
sEH
0
294,860,469
[N-]=[N+]=NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
N#Cc1cc(F)ccc1N
CC(C)(CN)CCS(C)(=O)=O.Cl
CC(C)(CCS(C)(=O)=O)CNc1nc(Nc2ccc(F)cc2C#N)nc(N[C@@H](CCCN=[N+]=[N-])C(=O)N[Dy])n1
BRD4
0
74,307,055
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COCC1(CN)CCCCC1
NCc1cnc(-c2ccccc2)s1
COCC1(CNc2nc(NCc3cnc(-c4ccccc4)s3)nc(NC(Cc3ccccc3)C(=O)N[Dy])n2)CCCCC1
HSA
0
168,351,696
O=C(Nc1cc(Cl)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCOC2(CCOCC2)C1
Cl.Cl.NCCc1nccn1C(F)F
O=C(N[Dy])c1cc(Cl)cc(Nc2nc(NCCc3nccn3C(F)F)nc(NCC3CCOC4(CCOCC4)C3)n2)c1
BRD4
0
153,911,886
O=C(Nc1c(I)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1nc(Cl)ncc1N
Nc1ccc(F)c([N+](=O)[O-])c1
COc1nc(Cl)ncc1Nc1nc(Nc2ccc(F)c([N+](=O)[O-])c2)nc(Nc2c(I)cccc2C(=O)N[Dy])n1
BRD4
0
15,430,020
CC(C)(C)OC(=O)N1C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)[C@H](C(=O)O)C1
COC(=O)c1cc(N)ccc1Cl
Cc1conc1CN
COC(=O)c1cc(Nc2nc(NCc3nocc3C)nc(N[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3C(=O)N[Dy])n2)ccc1Cl
BRD4
0
217,266,512
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.N=C(N)CCCN
NCc1c(Br)cncc1Br
N=C(CCCN)Nc1nc(NCc2c(Br)cncc2Br)nc(Nc2cccnc2C(=O)N[Dy])n1
sEH
0
122,842,524
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cccnc1N1CCC(C(N)=O)CC1
NCc1cnc(-c2ccccc2)o1
NC(=O)C1CCN(c2ncccc2CNc2nc(NCc3cnc(-c4ccccc4)o3)nc(N[C@H](Cc3ccc(Cl)cc3)C(=O)N[Dy])n2)CC1
BRD4
0
202,360,849
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cc(F)cc(F)c1
NCc1cccc2c1OCO2
O=C(N[Dy])c1cc(F)ccc1Nc1nc(NCc2cc(F)cc(F)c2)nc(NCc2cccc3c2OCO3)n1
HSA
0
1,417,894
C#CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CSc1ccc(CN)o1.Cl
NCc1noc2c1COCC2
C#CC[C@@H](Nc1nc(NCc2ccc(SC)o2)nc(NCc2noc3c2COCC3)n1)C(=O)N[Dy]
HSA
0
67,566,513
N#Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
C=CCSCCN
CSCc1nnc(CN)[nH]1.Cl
C=CCSCCNc1nc(NCc2nnc(CSC)[nH]2)nc(Nc2ccc(C#N)cc2C(=O)N[Dy])n1
BRD4
0
152,044,063
O=C(Nc1c(F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccc(Cl)cc1
Cn1cc(N)cn1
Cn1cc(Nc2nc(NCCNC(=O)c3ccc(Cl)cc3)nc(Nc3c(F)cccc3C(=O)N[Dy])n2)cn1
HSA
0
259,762,719
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc([N+](=O)[O-])c1
Cl.Cl.NCC=Cc1cccnc1
CS(=O)(=O)c1ccc(N)cc1
CS(=O)(=O)c1ccc(Nc2nc(NCC=Cc3cccnc3)nc(N[C@H](CC(=O)N[Dy])c3cccc([N+](=O)[O-])c3)n2)cc1
BRD4
0
177,475,087
O=C(Nc1cc(I)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc(CN2CCCCC2)c1
N#Cc1ccsc1N
N#Cc1ccsc1Nc1nc(Nc2cccc(CN3CCCCC3)c2)nc(Nc2cc(I)ccc2C(=O)N[Dy])n1
HSA
0
203,283,802
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cc(=O)[nH]c2ccccc12
Nc1nc(OCc2ccccc2)c2nc[nH]c2n1
O=C(N[Dy])c1cc(I)ccc1Nc1nc(NCc2cc(=O)[nH]c3ccccc23)nc(Nc2nc(OCc3ccccc3)c3nc[nH]c3n2)n1
HSA
0
118,718,366
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ncc([N+](=O)[O-])s1
Cc1ccc(N)c(CO)c1
Cc1ccc(Nc2nc(Nc3ncc([N+](=O)[O-])s3)nc(N[C@H](Cc3cc(F)cc(F)c3)C(=O)N[Dy])n2)c(CO)c1
sEH
0
258,063,370
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Nc1ccc2[nH]ncc2c1
Nc1nc(Cl)c2cn[nH]c2n1
O=C(C[C@@H](Nc1nc(Nc2ccc3[nH]ncc3c2)nc(Nc2nc(Cl)c3cn[nH]c3n2)n1)c1ccc(Cl)cc1)N[Dy]
HSA
0
73,148,888
O=C(NC(CCc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1CCN(C(=O)CN)CC1
Nc1nccc2cccnc12
CN1CCN(C(=O)CNc2nc(Nc3nccc4cccnc34)nc(NC(CCc3ccccc3)C(=O)N[Dy])n2)CC1
sEH
0
242,751,463
O=C(O)COc1cccc(-c2csc(NC(=O)OCC3c4ccccc4-c4ccccc43)n2)c1
Nc1ccc(Cl)c(C(F)(F)F)c1
Cl.NC1CCC(=O)CC1
O=C1CCC(Nc2nc(Nc3ccc(Cl)c(C(F)(F)F)c3)nc(Nc3nc(-c4cccc(OCC(=O)N[Dy])c4)cs3)n2)CC1
HSA
0
56,167,355
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.NCCC[C@@H]1NC(=O)NC1=O
NCC1(CO)CC=CC1
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(NCCC[C@@H]3NC(=O)NC3=O)nc(NCC3(CO)CC=CC3)n2)cc1
sEH
0
122,602,709
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCC1CCCC1(F)F
COCc1ccccc1CN
COCc1ccccc1CNc1nc(NCCC2CCCC2(F)F)nc(N[C@H](Cc2ccc(Cl)cc2)C(=O)N[Dy])n1
sEH
0
289,361,109
O=C(O)[C@H]1CCCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccc[nH]c1=O
Cn1nccc1[C@@H]1OCC[C@H]1CN
Cn1nccc1[C@@H]1OCC[C@H]1CNc1nc(NCc2ccc[nH]c2=O)nc(N2CCCC[C@@H]2C(=O)N[Dy])n1
BRD4
0
198,045,195
O=C(Nc1ccc(Cl)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1
Nc1nc2c(s1)CCCC2
O=C(N[Dy])c1cc(Nc2nc(Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)nc(Nc3nc4c(s3)CCCC4)n2)ccc1Cl
BRD4
0
198,814,659
O=C(Nc1ccc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(CN)c(=O)[nH]c1=O
C#CCOc1ccc(CN)cc1.Cl
C#CCOc1ccc(CNc2nc(NCc3cn(C)c(=O)[nH]c3=O)nc(Nc3ccc(Cl)cc3C(=O)N[Dy])n2)cc1
BRD4
0
218,948,400
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1ncc(Cl)c(Cl)n1
COC(=O)c1cc(OC)c(OC)cc1N
COC(=O)c1cc(OC)c(OC)cc1Nc1nc(Nc2ccnc(C(=O)N[Dy])c2)nc(Nc2ncc(Cl)c(Cl)n2)n1
BRD4
0
6,268,593
C=CCC(CC=C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1ccccc1N1CCOCC1
NCC12CC=CC(C1)OC2
C=CCC(CC=C)(Nc1nc(NCc2ccccc2N2CCOCC2)nc(NCC23CC=CC(C2)OC3)n1)C(=O)N[Dy]
BRD4
0
227,179,690
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCCC2(CCC2)C1O
Cl.NC[C@@H]1C[C@@H]2O[C@H]1[C@H]1C[C@H]12
O=C(N[Dy])c1ccc2nc(Nc3nc(NCC4CCCC5(CCC5)C4O)nc(NC[C@@H]4C[C@@H]5O[C@H]4[C@H]4C[C@H]45)n3)sc2c1
HSA
0
76,217,825
O=C(NC1(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ccc1Cl
COC(C)(CN)C1CC1
COC(C)(CNc1nc(Nc2nc(Cl)ccc2Cl)nc(NC2(C(=O)N[Dy])CC2)n1)C1CC1
sEH
0