T16	Negative_regulation 0 4	Loss
E1	Negative_regulation:T16 Theme:E2
T17	Positive_regulation 23 31	elevated
E2	Positive_regulation:T17 Theme:E3
T18	Gene_expression 32 42	expression
E3	Gene_expression:T18 Theme:T1
T19	Gene_expression 263 273	expression
E4	Gene_expression:T19 Theme:T5
T20	Negative_regulation 361 364	low
E5	Negative_regulation:T20 Theme:E6
T21	Gene_expression 379 389	expression
E6	Gene_expression:T21 Theme:T6
T22	Positive_regulation 483 492	elevation
E7	Positive_regulation:T22 Theme:T7
T23	Positive_regulation 582 590	increase
E8	Positive_regulation:T23 Theme:T8
T24	Gene_expression 792 799	express
E9	Gene_expression:T24 Theme:T9
T25	Positive_regulation 834 860	transcriptional activation
E10	Positive_regulation:T25 Theme:T9
T26	Transcription 916 929	transcription
E11	Transcription:T26 Theme:T9
T27	Positive_regulation 963 970	induced
E12	Positive_regulation:T27 Theme:E11
T28	Activation 1061 1070	activated
E13	Activation:T28 Theme:T9 Cause:T10
T29	Positive_regulation 1105 1118	up-regulation
E14	Positive_regulation:T29 Theme:T9 Cause:T10
T30	Regulation 1269 1280	association
E15	Regulation:T30 Theme:E16
M1	Negation E15
T31	Gene_expression 1288 1298	expression
E16	Gene_expression:T31 Theme:T11
T32	Gene_expression 1336 1346	expression
E17	Gene_expression:T32 Theme:T13
T33	Gene_expression 1499 1513	overexpression
E18	Gene_expression:T33 Theme:T15