LiteFold/InterPro · Datasets at Hugging Face

IPR006868

6,868

Domain of unknown function DUF630

DUF630

Domain

8,124

false

This region is sometimes found at the N terminus of putative plant bZIP proteins . The function of this conserved region is not known.

[]

0

[ "PFAM" ]

[ "PF04783" ]

[ "DUF630" ]

[ 8124 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 8124 ]

1

[ "Arabidopsis thaliana", "Mus musculus", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 81, 1, 54, 107 ]

4

true

Domain

Domain of unknown function DUF630

DUF630

9

IPR006869

6,869

Domain of unknown function DUF547

DUF547

Domain

14,647

false

This is a conserved region found in uncharacterised proteins from Caenorhabditis elegans and Arabidopsis thaliana (Mouse-ear cress).

[]

0

[ "PFAM" ]

[ "PF04784" ]

[ "DUF547" ]

[ 14647 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 148, 3004, 11435, 60 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 139, 4, 4, 51, 106 ]

5

true

Domain

Domain of unknown function DUF547

DUF547

6

IPR006870

6,870

Rhabdovirus matrix protein M

Rhabdo_M

Family

673

false

Matrix (M) protein is an important structural component of rhabdovirus virions, and also plays a number of roles during the replication cycle of the virus [ ]. It is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane. M interacts specifically with the transmembrane spike protei...

[ "GO:0016032", "GO:0019031" ]

[ "viral process", "viral envelope" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04785" ]

[ "Rhabdo_M2" ]

[ 673 ]

1

[]

0

[ "2w2s" ]

1

[ "PUB00008630", "PUB00050016" ]

[ "9847327", "19112510" ]

[ "Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G.", "Rhabdovirus matrix protein structures reveal a novel mode of self-association." ]

[ 1999, 2008 ]

2

[]

0

null

[ "Alpharhabdovirinae" ]

[ 673 ]

1

[]

0

true

Family

Rhabdovirus matrix protein M

Rhabdo_M

6

IPR006871

6,871

ssDNA-binding protein, baculovirus

ssDNA-bd_baculovirus

Family

172

false

This is a family of Baculovirus ssDNA-binding proteins.

[]

0

[ "PFAM" ]

[ "PF04786" ]

[ "Baculo_DNA_bind" ]

[ 172 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 172 ]

1

[]

0

true

Family

ssDNA-binding protein, baculovirus

ssDNA-bd_baculovirus

1

IPR006872

6,872

Late protein H7, poxvirus

Poxvirus_H7

Family

130

false

This is a family of poxvirus late H7 proteins.

[]

0

[ "PFAM" ]

[ "PF04787" ]

[ "Pox_H7" ]

[ 130 ]

1

[]

0

[ "4w5x", "4w60" ]

2

[]

0

[]

0

null

[ "Poxviridae" ]

[ 130 ]

1

[]

0

true

Family

Late protein H7, poxvirus

Poxvirus_H7

2

IPR006873

6,873

Protein of unknown function DUF620

DUF620

Family

4,820

false

This is a family of uncharacterised proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04788", "PTHR31300" ]

[ "DUF620", "" ]

[ 4760, 4753 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Embryophyta", "marine sediment metagenome" ]

[ 4, 4815, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 33, 47 ]

3

true

Family

Protein of unknown function DUF620

DUF620

8

IPR006874

6,874

Protein of unknown function DUF621

DUF621

Family

164

false

This is a conserved region found in uncharacterised proteins from Caenorhabditis elegans, and is noted to have possible G-protein-coupled receptor-like activity.

[]

0

[ "PFAM" ]

[ "PF04789" ]

[ "DUF621" ]

[ 164 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Finegoldia magna", "Opisthokonta" ]

[ 1, 163 ]

2

[ "Caenorhabditis elegans" ]

[ 15 ]

1

true

Family

Protein of unknown function DUF621

DUF621

6

IPR006875

6,875

Sarcoglycan complex subunit protein

Sarcoglycan

Family

5,539

false

The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglyc...

[ "GO:0016012", "GO:0016020" ]

[ "sarcoglycan complex", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04790" ]

[ "Sarcoglycan_1" ]

[ 5539 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9913351", "R-CFA-9913351", "R-HSA-9913351", "R-MMU-9913351" ]

[ "REACTOME:R-BTA-9913351", "REACTOME:R-CFA-9913351", "REACTOME:R-HSA-9913351", "REACTOME:R-MMU-9913351" ]

4

[ "8yt8", "9c3c" ]

2

[ "PUB00008631", "PUB00008632" ]

[ "12107060", "12189167" ]

[ "Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.", "Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy." ]

[ 2002, 2002 ]

2

[]

[ "IPR027659", "IPR039972" ]

0

2

0

[ "Gangjinia marincola", "Opisthokonta" ]

[ 1, 5538 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 16, 4, 12, 11, 17 ]

6

true

Family

Sarcoglycan complex subunit protein

Sarcoglycan

7

IPR006876

6,876

LMBR1-like membrane protein

LMBR1-like_membr_prot

Family

13,368

false

This group of proteins have a conserved C-terminal region which is found in LMBR1 and in the lipocalin-1 receptor. LMBR1 was thought to play a role in preaxial polydactyly, but recent evidence now suggests this not to be the case [ ]. Vertebrate members of this family may play a role in limb development [ ]. Lysosomal ...

[]

0

[ "PFAM" ]

[ "PF04791" ]

[ "LMBR1" ]

[ 13368 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-9758881", "R-DDI-9758890", "R-HSA-5683329", "R-HSA-9758881", "R-HSA-9758890", "R-MMU-9758881", "R-MMU-9758890" ]

[ "REACTOME:R-DDI-9758881", "REACTOME:R-DDI-9758890", "REACTOME:R-HSA-5683329", "REACTOME:R-HSA-9758881", "REACTOME:R-HSA-9758890", "REACTOME:R-MMU-9758881", "REACTOME:R-MMU-9758890" ]

7

[]

0

[ "PUB00009031", "PUB00010385", "PUB00019801", "PUB00094243", "PUB00094244" ]

[ "12032320", "11287427", "11090342", "19136951", "25535791" ]

[ "Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.", "Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display.", "Acheiropodia is caused by a genomic deletion in C7orf2, the human orthologue of the Lmbr1 gene.", "Identification o...

[ 2002, 2001, 2001, 2009, 2014 ]

5

[]

[ "IPR008075" ]

0

1

0

[ "Bacillus", "Eukaryota", "Klosneuvirinae" ]

[ 20, 13346, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 8, 3, 9, 4, 27, 9, 2, 5, 14, 1, 53 ]

11

true

Family

LMBR1-like membrane protein

LMBR1-like_membr_prot

1

IPR006879

6,879

Carbohydrate deacetylase YdjC-like

YdjC-like

Family

8,756

false

This entry includes YdjC deacetylase-like proteins [ ], including chitooligosaccharide deacetylase ChbG [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04794", "PTHR31609" ]

[ "YdjC", "" ]

[ 8746, 8389 ]

2

[ "EC", "GP" ]

[ "3.5.1.105", "GenProp1293" ]

[ "EC:3.5.1.105", "GP:GenProp1293" ]

2

[ "2e67", "2i5i", "7vi8", "8jqe", "8jqf" ]

5

[ "PUB00047343", "PUB00074303" ]

[ "18177738", "22797760" ]

[ "Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase.", "The chbG gene of the chitobiose (chb) operon of Escherichia coli encodes a chitooligosaccharide deacetylase." ]

[ 2008, 2012 ]

2

[]

[ "IPR017836", "IPR022948" ]

0

2

0

[ "Bacteria", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA259D18", "unclassified sequences" ]

[ 7398, 1201, 1, 156 ]

4

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 1, 4, 4 ]

5

true

Family

Carbohydrate deacetylase YdjC-like

YdjC-like

2

IPR006880

6,880

INO80 complex subunit B-like conserved region

INO80B_C

Domain

4,366

false

This is a group of proteins with a conserved C-terminal region which is found in INO80 complex subunit B (INO80B, Ies2 homologue, also known as PAPA-1). INO80B is a component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair [ , ].

[ "GO:0031011" ]

[ "Ino80 complex" ]

[ "cellular_component" ]

1

[ "PFAM", "SMART" ]

[ "PF04795", "SM01406" ]

[ "PAPA-1", "PAPA-1" ]

[ 4064, 4332 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5689603", "R-HSA-5696394", "R-MMU-5689603", "R-MMU-5696394" ]

[ "REACTOME:R-HSA-5689603", "REACTOME:R-HSA-5696394", "REACTOME:R-MMU-5689603", "REACTOME:R-MMU-5696394" ]

4

[ "6fhs", "6fml", "6hts", "7zi4", "8atf", "8av6", "8euf", "8oo7", "8ooc", "8oop", "8oor", "9c9g", "9c9s", "9c9t", "9c9z", "9can", "9cat", "9cb7", "9ccd", "9gcg", "9ge5", "9gev", "9gf6", "9gfb" ]

24

[ "PUB00062156", "PUB00066961" ]

[ "21303910", "15556297" ]

[ "Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.", "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase." ]

[ 2011, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4366 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 17, 1, 4, 5, 4, 2, 10, 3, 1, 1, 20 ]

11

true

Domain

INO80 complex subunit B-like conserved region

INO80B_C

9

IPR006881

6,881

Plasmid encoded RepA protein

RepA_C

Family

1,492

false

This is a family of plasmid encoded proteins involved in plasmid replication. The role of RepA in the replication process is not clearly understood [ ].

[]

0

[ "PFAM" ]

[ "PF04796" ]

[ "RepA_C" ]

[ 1492 ]

1

[]

0

[]

0

[ "PUB00008634" ]

[ "11914352" ]

[ "Origin binding activity of the Mycobacterial plasmid pAL5000 replication protein RepB is stimulated through interactions with host factors and coupled expression of repA." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 1479, 5, 2, 6 ]

4

[]

0

true

Family

Plasmid encoded RepA protein

RepA_C

2

IPR006882

6,882

Herpesvirus Orf11

Herpes_Orf11

Family

311

false

This family of proteins are found in Herpesvirus. This family includes proteins called ORF10 and ORF11 amongst others.

[]

0

[ "PFAM" ]

[ "PF04797" ]

[ "Herpes_ORF11" ]

[ 311 ]

1

[ "REACTOME" ]

[ "R-HSA-9609690" ]

[ "REACTOME:R-HSA-9609690" ]

1

[ "7byf" ]

1

[]

0

[]

0

null

[ "Orthoherpesviridae" ]

[ 311 ]

1

[]

0

true

Family

Herpesvirus Orf11

Herpes_Orf11

3

IPR006883

6,883

Per os infectivity factor 4

AcMNPV_PIF-4

Family

174

false

This family of viral proteins is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) Orf96, which encodes a per os infectivity factor (PIF-4) [ ]. Baculoviruses encode per os infectivity factors (PIFs) on the envelope surface of occlusion-derived virus (ODV) to initiate the efficient primary infec...

[]

0

[ "PFAM" ]

[ "PF04798" ]

[ "Baculo_19" ]

[ 174 ]

1

[]

0

[]

0

[ "PUB00082591" ]

[ "19759145" ]

[ "Autographa californica multiple nucleopolyhedrovirus core gene ac96 encodes a per Os infectivity factor (PIF-4)." ]

[ 2009 ]

1

[]

0

null

[ "Lefavirales", "Neoptera" ]

[ 163, 11 ]

2

[]

0

true

Family

Per os infectivity factor 4

AcMNPV_PIF-4

5

IPR006884

6,884

Fzo/mitofusin HR2 domain

Fzo/mitofusin_HR2

Domain

3,843

false

This entry represents the heptad repeat domain which is conserved at the C terminus of Fzo/mitofusion family of GTPases. Fzo is a mediator of mitochondrial fusion during spermatogenesis [ ]. This conserved region is also found in the human mitofusin protein [ ]. This domain forms a dimeric antiparallel coiled coil stru...

[ "GO:0003924", "GO:0008053", "GO:0005741", "GO:0016020" ]

[ "GTPase activity", "mitochondrial fusion", "mitochondrial outer membrane", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF04799" ]

[ "Fzo_mitofusin" ]

[ 3843 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.5.-", "R-CEL-5205685", "R-CEL-9013419", "R-CEL-983231", "R-DME-5205685", "R-DME-9013419", "R-DME-983231", "R-HSA-5205685", "R-HSA-9013419", "R-HSA-983231", "R-MMU-5205685", "R-MMU-9013419", "R-MMU-983231", "R-RNO-5205685", "R-RNO-9013419", "R-RNO-983231" ]

[ "EC:3.6.5.-", "REACTOME:R-CEL-5205685", "REACTOME:R-CEL-9013419", "REACTOME:R-CEL-983231", "REACTOME:R-DME-5205685", "REACTOME:R-DME-9013419", "REACTOME:R-DME-983231", "REACTOME:R-HSA-5205685", "REACTOME:R-HSA-9013419", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-5205685", "REACTOME:R-MMU-9013419...

16

[ "1t3j", "5gnr", "5gns", "5gnt", "5gnu", "5go4", "5goe", "5gof", "5gom", "5yew", "6jfk", "6jfl", "6jfm" ]

13

[ "PUB00008635", "PUB00008636", "PUB00031311" ]

[ "9230308", "11181170", "15297672" ]

[ "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.", "Control of mitochondrial morphology by a human mitofusin.", "Structural basis of mitochondrial tethering by mitofusin complexes." ]

[ 1997, 2001, 2004 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 2, 3841 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 13, 2, 14, 6, 10 ]

6

true

Domain

Fzo/mitofusin HR2 domain

Fzo/mitofusin_HR2

1

IPR006885

6,885

NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like

NADH_UbQ_FeS_4_mit-like

Family

8,516

false

This entry includes NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 (NDUS4), an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), initially identified in Neurospora crassa as a 21kDa protein [ , ]. It is believed that members of this family are not involved in catal...

[ "GO:0022900" ]

[ "electron transport chain" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04800", "PTHR12219" ]

[ "NDUS4", "" ]

[ 7570, 7940 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-BTA-611105", "R-BTA-6799198", "R-DME-611105", "R-DME-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198", "R-RNO-611105", "R-RNO-6799198" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-611105", "REACTOME:R-RNO-6799198" ]

12

[ "2jya", "2lju", "5gpn", "5gup", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6x89", "6y79", "6yj4", "6zk9"...

261

[ "PUB00008637", "PUB00098647" ]

[ "7947902", "19675153" ]

[ "Complementary DNA sequences of the 24 kDa and 21 kDa subunits of complex I from Neurospora.", "Remodeled respiration in ndufs4 with low phosphorylation efficiency suppresses Arabidopsis germination and growth and alters control of metabolism at night." ]

[ 1994, 2009 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati", "unclassified sequences" ]

[ 5328, 3147, 41 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 3, 1, 6, 6, 1, 2, 5, 13 ]

10

true

Family

NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like

NADH_UbQ_FeS_4_mit-like

7

IPR006886

6,886

DNA-directed RNA polymerase III subunit Rpc5

RNA_pol_III_Rpc5

Family

5,363

false

DNA-dependent RNA polymerase catalyses the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. RNA polymerase III (Pol III) is a complex consisting of 17 subunits, which synthesizes small RNAs, such as 5S rRNA and tRNAs. Pol III is essential for efficient transcription from both the...

[ "GO:0006351", "GO:0005634" ]

[ "DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04801", "PTHR12069" ]

[ "RPC5", "" ]

[ 5277, 5187 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071" ]

[ "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-MMU-76071" ]

10

[ "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7ast", "7asu", "7asv", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l", "7z1m"...

55

[ "PUB00060118", "PUB00095453" ]

[ "19631370", "32843346" ]

[ "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.", "A mutation in POLR3E impairs antiviral immune response and RNA polymerase III." ]

[ 2009, 2020 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5363 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 5, 11, 3, 1, 2, 4, 1, 1, 9 ]

12

true

Family

DNA-directed RNA polymerase III subunit Rpc5

RNA_pol_III_Rpc5

2

IPR006887

6,887

Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain

P4R3-like_central_dom

Domain

8,157

false

This entry represents a domain found in Serine/threonine-protein phosphatase 4 regulatory subunit 3A/B/C from humans (P4R3A/B/C, also known as SMEK homologue 1/2/3) and similar proteins from eukaryotes. P4R3B is a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) that form a complex with its catalytic ...

[]

0

[ "PFAM" ]

[ "PF04802" ]

[ "PP4R3" ]

[ 8157 ]

1

[]

0

[]

0

[ "PUB00090308", "PUB00101024", "PUB00101025", "PUB00101026" ]

[ "18715871", "16085932", "16530049", "20951350" ]

[ "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.", "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.", "SMK-1, an essential regulator of DAF-16-mediated longevity.", "A Mec1- and PP4-dependent checkpoint couples centromer...

[ 2008, 2005, 2006, 2010 ]

4

[]

0

null

[ "Eukaryota" ]

[ 8157 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 2, 3, 3, 8, 10, 1, 8, 18, 1, 1, 43 ]

12

true

Domain

Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain

P4R3-like_central_dom

7

IPR006888

6,888

XLR/SYCP3/FAM9 domain

XLR/SYCP3/FAM9_dom

Domain

1,409

false

This entry represents a conserved region found in the members of the FAM9 and XLR/SYCP3 families. SYCP3, also known as COR1, is a component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase [ , ].

[]

0

[ "PFAM" ]

[ "PF04803" ]

[ "Cor1" ]

[ 1409 ]

1

[ "REACTOME" ]

[ "R-HSA-1221632" ]

[ "REACTOME:R-HSA-1221632" ]

1

[ "4cpc", "6dd8", "6dd9" ]

3

[ "PUB00075470", "PUB00075471" ]

[ "22346761", "10678170" ]

[ "Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.", "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility." ]

[ 2012, 2000 ]

2

[]

0

null

[ "Metazoa" ]

[ 1409 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 94, 27 ]

4

true

Domain

XLR/SYCP3/FAM9 domain

XLR/SYCP3/FAM9_dom

9

IPR006889

6,889

Nonstructural protein NSM

Bunya_NSM

Family

357

false

This is a family of plant infecting tospovirus NSM proteins a number of which contain the phospholipase A2 histidine active site, .

[]

0

[ "PIRSF" ]

[ "PIRSF003959" ]

[ "NS-M_TospoV" ]

[ 357 ]

1

[]

0

[]

0

[]

0

[ "IPR000603" ]

[]

1

0

1

[ "Viruses" ]

[ 357 ]

1

[]

0

true

Family

Nonstructural protein NSM

Bunya_NSM

8

IPR006890

6,890

Sulphydryl oxidase, FAD-linked, ERV1/ALR-type

Sulphydryl_Oase_FAD-link_ERV1

Family

114

false

This entry represents a family of probable FAD-linked sulphydryl oxidases found in poxviruses.

[ "GO:0016972" ]

[ "thiol oxidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF" ]

[ "PF04805", "PIRSF015696" ]

[ "Pox_E10", "VAC_E10R" ]

[ 114, 108 ]

2

[ "EC", "METACYC" ]

[ "1.8.3.2", "PWY-7533" ]

[ "EC:1.8.3.2", "METACYC:PWY-7533" ]

2

[]

0

[]

0

[]

0

null

[ "Poxviridae" ]

[ 114 ]

1

[]

0

true

Family

Sulphydryl oxidase, FAD-linked, ERV1/ALR-type

Sulphydryl_Oase_FAD-link_ERV1

9

IPR006891

6,891

Type III secretion protein EspF

T3SS_EspF

Repeat

158

false

Enteropathogenic Escherichia coli O127:H6 attaches to the intestinal mucosa through actin pedestals that are created after it has injected the Type III secretion protein EspF (E. coli secreted protein F-like protein from prophage U) into the cells. EspF recruits the actin machinery by activating the WASP (Wiscott-Aldri...

[]

0

[ "PFAM" ]

[ "PF04806" ]

[ "EspF" ]

[ 158 ]

1

[]

0

[ "2k42", "2kxc", "2lnh", "9r3y", "9r4v", "9r4w" ]

6

[ "PUB00008642", "PUB00044746", "PUB00044747" ]

[ "11298644", "18650806", "15533930" ]

[ "Role of EspF in host cell death induced by enteropathogenic Escherichia coli.", "The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency.", "Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16...

[ 2001, 2008, 2005 ]

3

[]

0

null

[ "Bacteria", "Fungi" ]

[ 156, 2 ]

2

[]

0

true

Repeat

Type III secretion protein EspF

T3SS_EspF

1

IPR006892

6,892

Geminivirus AC4/5, conserved domain 1

Gemini_AC4_5_cons_dom_1

Domain

654

false

This entry represents a conserved domain found in Gemini virus AC4 and AC5 proteins [ ].

[]

0

[ "PFAM" ]

[ "PF04807" ]

[ "Gemini_AC4_5" ]

[ 654 ]

1

[]

0

[]

0

[ "PUB00017093" ]

[ "7844539" ]

[ "Tomato leaf curl geminivirus from India has a bipartite genome and coat protein is not essential for infectivity." ]

[ 1995 ]

1

[]

0

null

[ "Geminiviridae" ]

[ 654 ]

1

[]

0

true

Domain

Geminivirus AC4/5, conserved domain 1

Gemini_AC4_5_cons_dom_1

8

IPR006893

6,893

Citrus tristeza virus P23 protein

CTV_P23

Family

619

false

This family of proteins contains p23 from the citrus tristeza virus, which is a member of the Closteroviridae. CTV produces more positive than negative RNA strands, and p23 controls this asymmetrical RNA accumulation. Amino acids 42-180 are essential for function and are thought to contain RNA-binding and zinc finger d...

[]

0

[ "PFAM" ]

[ "PF04808" ]

[ "CTV_P23" ]

[ 619 ]

1

[]

0

[]

0

[ "PUB00008643" ]

[ "11752137" ]

[ "The p23 protein of citrus tristeza virus controls asymmetrical RNA accumulation." ]

[ 2002 ]

1

[]

0

null

[ "Citrus tristeza virus" ]

[ 619 ]

1

[]

0

true

Family

Citrus tristeza virus P23 protein

CTV_P23

5

IPR006894

6,894

HupH hydrogenase expression protein, C-terminal

HupH_Hydgase_express_prot_C

Domain

2,267

false

This entry represents the C-terminal conserved domain found in bacterial hydrogenase expression proteins (HupH), which are necessary for hydrogenase synthesis. The precise function of HupH is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF04809" ]

[ "HupH_C" ]

[ 2267 ]

1

[]

0

[ "3sb1" ]

1

[ "PUB00008644" ]

[ "8045431" ]

[ "Organization of the hydrogenase gene cluster from Bradyrhizobium japonicum: sequences and analysis of five more hydrogenase-related genes." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2240, 4, 23 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

HupH hydrogenase expression protein, C-terminal

HupH_Hydgase_express_prot_C

2

IPR006895

6,895

Zinc finger, Sec23/Sec24-type

Znf_Sec23_Sec24

Domain

23,720

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0008270", "GO:0006886", "GO:0006888", "GO:0030127" ]

[ "zinc ion binding", "intracellular protein transport", "endoplasmic reticulum to Golgi vesicle-mediated transport", "COPII vesicle coat" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF04810" ]

[ "zf-Sec23_Sec24" ]

[ 23720 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-204005", "R-BTA-2132295", "R-BTA-5694530", "R-BTA-983170", "R-DDI-204005", "R-DDI-5694530", "R-DDI-983170", "R-DRE-204005", "R-DRE-2132295", "R-DRE-983170", "R-HSA-1655829", "R-HSA-204005", "R-HSA-2132295", "R-HSA-5694530", "R-HSA-9705671", "R-HSA-983170", "R-MMU-204005", "R...

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-5694530", "REACTOME:R-BTA-983170", "REACTOME:R-DDI-204005", "REACTOME:R-DDI-5694530", "REACTOME:R-DDI-983170", "REACTOME:R-DRE-204005", "REACTOME:R-DRE-2132295", "REACTOME:R-DRE-983170", "REACTOME:R-HSA-1655829", "REACTOME:R-HS...

29

[ "1m2o", "1m2v", "1pcx", "1pd0", "1pd1", "2nup", "2nut", "2qtv", "2yrc", "2yrd", "3efo", "3eg9", "3egd", "3egx", "3eh1", "3eh2", "4bzi", "5kyn", "5kyu", "5kyw", "5kyx", "5kyy", "5vne", "5vnf", "5vng", "5vnh", "5vni", "5vnj", "5vnk", "5vnl", "5vnm", "5vnn"...

37

[ "PUB00014077", "PUB00014931", "PUB00014933", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "11535824", "12239560", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.", "Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger prote...

[ 2002, 2001, 2002, 2007, 2005, 2005, 1999, 2001 ]

8

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 23, 23697 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 45, 3, 25, 10, 26, 26, 3, 24, 25, 4, 4, 113 ]

12

true

Domain

Zinc finger, Sec23/Sec24-type

Znf_Sec23_Sec24

6

IPR006896

6,896

Sec23/Sec24, trunk domain

Sec23/24_trunk_dom

Domain

26,222

false

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [ ]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and ...

[ "GO:0006886", "GO:0006888", "GO:0030127" ]

[ "intracellular protein transport", "endoplasmic reticulum to Golgi vesicle-mediated transport", "COPII vesicle coat" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04811" ]

[ "Sec23_trunk" ]

[ 26222 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-204005", "R-BTA-2132295", "R-BTA-5694530", "R-BTA-983170", "R-DDI-204005", "R-DDI-5694530", "R-DDI-983170", "R-DRE-204005", "R-DRE-2132295", "R-DRE-983170", "R-HSA-1655829", "R-HSA-204005", "R-HSA-2132295", "R-HSA-5694530", "R-HSA-9705671", "R-HSA-983170", "R-MMU-204005", "R...

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-5694530", "REACTOME:R-BTA-983170", "REACTOME:R-DDI-204005", "REACTOME:R-DDI-5694530", "REACTOME:R-DDI-983170", "REACTOME:R-DRE-204005", "REACTOME:R-DRE-2132295", "REACTOME:R-DRE-983170", "REACTOME:R-HSA-1655829", "REACTOME:R-HS...

29

[ "1m2o", "1m2v", "1pcx", "1pd0", "1pd1", "2nup", "2nut", "2qtv", "3efo", "3eg9", "3egd", "3egx", "3eh1", "3eh2", "4bzi", "5kyn", "5kyu", "5kyw", "5kyx", "5kyy", "5vne", "5vnf", "5vng", "5vnh", "5vni", "5vnj", "5vnk", "5vnl", "5vnm", "5vnn", "5vno", "6gni"...

35

[ "PUB00014931", "PUB00014933" ]

[ "11535824", "12239560" ]

[ "Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.", "Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat." ]

[ 2001, 2002 ]

2

[]

[ "IPR041742" ]

0

1

0

[ "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "marine sediment metagenome" ]

[ 1, 26216, 5 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 45, 3, 25, 11, 27, 29, 3, 34, 27, 5, 4, 159 ]

12

true

Domain

Sec23/Sec24, trunk domain

Sec23/24_trunk_dom

4

IPR006897

6,897

Hepatocyte nuclear factor 1, beta isoform, C-terminal

HNF1b_C

Domain

2,438

false

This domain consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is re...

[ "GO:0045893", "GO:0005634" ]

[ "positive regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04812" ]

[ "HNF-1B_C" ]

[ 2438 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-210744", "R-HSA-210745", "R-HSA-210747", "R-HSA-9831926", "R-HSA-9925561", "R-HSA-9925563", "R-HSA-9937080" ]

[ "REACTOME:R-HSA-210744", "REACTOME:R-HSA-210745", "REACTOME:R-HSA-210747", "REACTOME:R-HSA-9831926", "REACTOME:R-HSA-9925561", "REACTOME:R-HSA-9925563", "REACTOME:R-HSA-9937080" ]

7

[]

0

[ "PUB00008645", "PUB00008646" ]

[ "7900999", "9133564" ]

[ "More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.", "A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an o...

[ 1993, 1997 ]

2

[]

0

null

[ "Vertebrata" ]

[ 2438 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 24, 5, 7 ]

4

true

Domain

Hepatocyte nuclear factor 1, beta isoform, C-terminal

HNF1b_C

9

IPR006898

6,898

Hepatocyte nuclear factor 1, alpha isoform C-terminal

HNF1a_C

Domain

900

false

This domain consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of tr...

[ "GO:0045893", "GO:0005634" ]

[ "positive regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04813" ]

[ "HNF-1A_C" ]

[ 900 ]

1

[ "REACTOME" ]

[ "R-HSA-210745" ]

[ "REACTOME:R-HSA-210745" ]

1

[]

0

[ "PUB00008645", "PUB00008646" ]

[ "7900999", "9133564" ]

[ "More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.", "A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an o...

[ 1993, 1997 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 900 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 10, 2, 2 ]

4

true

Domain

Hepatocyte nuclear factor 1, alpha isoform C-terminal

HNF1a_C

5

IPR006899

6,899

Hepatocyte nuclear factor 1, N-terminal

HNF-1_N

Domain

5,244

false

This domain consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence [ ] and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of ...

[ "GO:0045893", "GO:0005634" ]

[ "positive regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04814" ]

[ "HNF-1_N" ]

[ 5244 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-210744", "R-HSA-210745", "R-HSA-210747", "R-HSA-9831926", "R-HSA-9925561", "R-HSA-9925563", "R-HSA-9937080" ]

[ "REACTOME:R-HSA-210744", "REACTOME:R-HSA-210745", "REACTOME:R-HSA-210747", "REACTOME:R-HSA-9831926", "REACTOME:R-HSA-9925561", "REACTOME:R-HSA-9925563", "REACTOME:R-HSA-9937080" ]

7

[ "1ic8", "2h8r", "8pi7", "8pi8", "8pi9", "8pia" ]

6

[ "PUB00008646", "PUB00008647" ]

[ "9133564", "1988016" ]

[ "A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge.", "1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1." ]

[ 1997, 1991 ]

2

[]

0

null

[ "Metazoa" ]

[ 5244 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 22, 31, 16, 12 ]

5

true

Domain

Hepatocyte nuclear factor 1, N-terminal

HNF-1_N

4

IPR006900

6,900

Sec23/Sec24, helical domain

Sec23/24_helical_dom

Domain

24,430

false

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [ ]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and ...

[ "GO:0006886", "GO:0006888", "GO:0030127" ]

[ "intracellular protein transport", "endoplasmic reticulum to Golgi vesicle-mediated transport", "COPII vesicle coat" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04815" ]

[ "Sec23_helical" ]

[ 24430 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-204005", "R-BTA-2132295", "R-BTA-5694530", "R-BTA-983170", "R-DDI-204005", "R-DDI-5694530", "R-DDI-983170", "R-DRE-204005", "R-DRE-2132295", "R-DRE-983170", "R-HSA-1655829", "R-HSA-204005", "R-HSA-2132295", "R-HSA-5694530", "R-HSA-9705671", "R-HSA-983170", "R-MMU-204005", "R...

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-5694530", "REACTOME:R-BTA-983170", "REACTOME:R-DDI-204005", "REACTOME:R-DDI-5694530", "REACTOME:R-DDI-983170", "REACTOME:R-DRE-204005", "REACTOME:R-DRE-2132295", "REACTOME:R-DRE-983170", "REACTOME:R-HSA-1655829", "REACTOME:R-HS...

29

[ "1m2o", "1m2v", "1pcx", "1pd0", "1pd1", "2nup", "2nut", "2qtv", "3efo", "3eg9", "3egd", "3egx", "3eh1", "3eh2", "4bzi", "5kyn", "5kyu", "5kyw", "5kyx", "5kyy", "5vne", "5vnf", "5vng", "5vnh", "5vni", "5vnj", "5vnk", "5vnl", "5vnm", "5vnn", "5vno", "6gni"...

35

[ "PUB00014931", "PUB00014933" ]

[ "11535824", "12239560" ]

[ "Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.", "Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 24430 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 44, 3, 25, 10, 26, 23, 3, 34, 25, 4, 4, 117 ]

12

true

Domain

Sec23/Sec24, helical domain

Sec23/24_helical_dom

5

IPR006901

6,901

tRNA methyltransferase TrmK

TrmK

Family

5,860

false

This family of proteins includes the tRNA methyltransferase TrmK, which catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA [ ].

[ "GO:0160105" ]

[ "tRNA (adenine(22)-N1)-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF" ]

[ "PF04816", "PIRSF018637" ]

[ "TrmK", "TrmK" ]

[ 4659, 5704 ]

2

[]

0

[ "3gnl", "3kr9", "3ku1", "3lec", "6q56", "6qe6", "7o4m", "7o4n", "7o4o" ]

9

[ "PUB00057355" ]

[ "18420655" ]

[ "The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK)." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ct2th6", "metagenomes" ]

[ 5822, 15, 1, 22 ]

4

[]

0

true

Family

tRNA methyltransferase TrmK

TrmK

8

IPR006902

6,902

Umbravirus long distance movement protein

Umbravirus_LDM

Family

76

false

The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants [ ].

[]

0

[ "PFAM" ]

[ "PF04817" ]

[ "Umbravirus_LDM" ]

[ 76 ]

1

[]

0

[]

0

[ "PUB00008648" ]

[ "11601910" ]

[ "Umbravirus-encoded proteins both stabilize heterologous viral RNA and mediate its systemic movement in some plant species." ]

[ 2001 ]

1

[]

0

null

[ "Orthornavirae" ]

[ 76 ]

1

[]

0

true

Family

Umbravirus long distance movement protein

Umbravirus_LDM

4

IPR006904

6,904

Protein of unknown function DUF716

DUF716

Family

7,451

false

These sequences are a family of uncharacterised hypothetical proteins restricted to eukaryotes ( ) represents a sequence from Nicotiana tabacum (Common tobacco) which is up regulated in response to TMV infection.

[]

0

[ "PFAM" ]

[ "PF04819" ]

[ "DUF716" ]

[ 7451 ]

1

[]

0

[ "7oqz" ]

1

[]

0

[]

[ "IPR042127" ]

0

1

0

[ "Eukaryota" ]

[ 7451 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 25, 2, 6, 17, 20, 20, 21 ]

7

true

Family

Protein of unknown function DUF716

DUF716

4

IPR006906

6,906

Timeless, N-terminal

Timeless_N

Domain

5,143

false

This entry represents the N-terminal domain of the Timeless protein. The timeless gene in Drosophila melanogaster is involved in circadian rhythm control [ ]. Drosophila contains two paralogues, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (...

[]

0

[ "PFAM" ]

[ "PF04821" ]

[ "TIMELESS" ]

[ 5143 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-432395", "R-DME-432490", "R-DME-432501", "R-DME-432553", "R-DME-432620", "R-DME-538898", "R-HSA-5693607", "R-MMU-5693607", "R-RNO-5693607" ]

[ "REACTOME:R-DME-432395", "REACTOME:R-DME-432490", "REACTOME:R-DME-432501", "REACTOME:R-DME-432553", "REACTOME:R-DME-432620", "REACTOME:R-DME-538898", "REACTOME:R-HSA-5693607", "REACTOME:R-MMU-5693607", "REACTOME:R-RNO-5693607" ]

9

[ "5mqi", "6skl", "6xwx", "7pfo", "7plo", "7pmk", "7pmn", "8b9a", "8b9b", "8b9c", "8b9d", "8dd7", "8kg6", "8ouw", "8xgc", "9e2w", "9e2x" ]

17

[ "PUB00008650", "PUB00016387", "PUB00045036", "PUB00093466", "PUB00097687", "PUB00097689", "PUB00097690", "PUB00097691", "PUB00097692" ]

[ "11710984", "15367656", "12944972", "26344098", "19819872", "23418588", "10417378", "10899011", "32469068" ]

[ "Flies, clocks and evolution.", "Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.", "S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.", "Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.", "Csm3, Tof1, and Mr...

[ 2001, 2004, 2003, 2015, 2009, 2013, 1999, 2000, 2020 ]

9

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5142, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 12, 2, 4, 1, 3, 5, 1, 1, 9 ]

12

true

Domain

Timeless, N-terminal

Timeless_N

1

IPR006907

6,907

Disks large homolog 5, N-terminal

DLG5_N

Domain

2,482

false

This entry represents a domain found at the N-terminal of disks large homologue 5 (DLG5) from humans and similar proteins mainly found in chordates. It is is named takusan after a Japanese word meaning 'many'. Members of this group regulate synaptic activity [ ]. DLG5 acts as a regulator of the Hippo signaling pathway ...

[]

0

[ "PFAM" ]

[ "PF04822" ]

[ "Takusan" ]

[ 2482 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9013420", "R-HSA-9013424", "R-HSA-9696264", "R-HSA-9696270", "R-HSA-9696273", "R-MMU-9013420", "R-MMU-9013424", "R-MMU-9696264", "R-MMU-9696270", "R-MMU-9696273" ]

[ "REACTOME:R-HSA-9013420", "REACTOME:R-HSA-9013424", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-9013420", "REACTOME:R-MMU-9013424", "REACTOME:R-MMU-9696264", "REACTOME:R-MMU-9696270", "REACTOME:R-MMU-9696273" ]

10

[]

0

[ "PUB00057464", "PUB00101304", "PUB00101305" ]

[ "17610818", "28087714", "28169360" ]

[ "Takusan: a large gene family that regulates synaptic activity.", "DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.", "Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway." ]

[ 2007, 2016, 2017 ]

3

[]

0

null

[ "Bilateria" ]

[ 2482 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 2, 261, 231 ]

4

true

Domain

Disks large homolog 5, N-terminal

DLG5_N

7

IPR006908

6,908

Herpesvirus UL49 tegument protein

Herpes_UL49

Family

245

false

This is a family of herpesvirus UL49 tegument proteins. It was shown that interactions between herpesvirus envelope and tegument proteins may play a role in secondary envelopment during herpesvirus virion maturation.

[]

0

[ "PFAM" ]

[ "PF04823" ]

[ "Herpes_UL49_2" ]

[ 245 ]

1

[]

0

[ "4xal" ]

1

[]

0

[]

0

null

[ "Alphaherpesvirinae" ]

[ 245 ]

1

[]

0

true

Family

Herpesvirus UL49 tegument protein

Herpes_UL49

8

IPR006909

6,909

Rad21/Rec8-like protein, C-terminal, eukaryotic

Rad21/Rec8_C_eu

Domain

8,901

false

This domain represents a conserved C-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Rad21/Rec8 like proteins mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex [ ]. Cohesion is necessary for homologous recombination (including double-strand b...

[]

0

[ "PFAM" ]

[ "PF04824" ]

[ "Rad21_Rec8" ]

[ 8901 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2467813", "R-BTA-2468052", "R-BTA-2470946", "R-BTA-2500257", "R-BTA-3108214", "R-CEL-2468052", "R-CEL-2470946", "R-CEL-2500257", "R-CEL-3108214", "R-HSA-1221632", "R-HSA-2467813", "R-HSA-2468052", "R-HSA-2470946", "R-HSA-2500257", "R-HSA-3108214", "R-HSA-9018519", "R-MMU-24678...

[ "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2468052", "REACTOME:R-BTA-2470946", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-3108214", "REACTOME:R-CEL-2468052", "REACTOME:R-CEL-2470946", "REACTOME:R-CEL-2500257", "REACTOME:R-CEL-3108214", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-2467813", "REACTOM...

27

[ "1w1w", "6qpq", "6qpw", "6wg3", "6wge", "6yuf", "6zz6", "7w1m", "7zjs", "8p0a", "8pq5", "8ro6", "8ro7", "8ro8", "8ro9", "8roa", "8rob", "8roc", "8rod", "8roe", "8rof", "8rog" ]

22

[ "PUB00008651", "PUB00008652" ]

[ "11687503", "10207075" ]

[ "The molecular basis of sister-chromatid cohesion.", "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans." ]

[ 2001, 1999 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 7, 8, 8885, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 25, 9, 15, 3, 8, 9, 2, 13, 6, 1, 2, 42 ]

12

true

Domain

Rad21/Rec8-like protein, C-terminal, eukaryotic

Rad21/Rec8_C_eu

4

IPR006911

6,911

Armadillo repeat-containing domain

ARM-rpt_dom

Domain

3,910

false

This domain contains armadillo-like repeats [ ]. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis [ ], control of cellular ageing and survival [ ], regulation of circadian rhythm [ ] and lysosomal ...

[]

0

[ "PFAM" ]

[ "PF04826" ]

[ "Arm_2" ]

[ 3910 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9013404", "R-MMU-9013404", "R-RNO-9013404" ]

[ "REACTOME:R-HSA-9013404", "REACTOME:R-MMU-9013404", "REACTOME:R-RNO-9013404" ]

3

[]

0

[ "PUB00057475", "PUB00057476", "PUB00057477", "PUB00057478" ]

[ "15034937", "17904127", "11597585", "12142540" ]

[ "Characterizing the new transcription regulator protein p60TRP.", "SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.", "A novel protein interacts with a clock-related protein, rPer1.", "Modulation of postendocytic sorting of G protein-coupled receptors." ]

[ 2004, 2007, 2001, 2002 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 3907 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 22, 24, 28 ]

5

true

Domain

Armadillo repeat-containing domain

ARM-rpt_dom

6

IPR006912

6,912

Harbinger transposase-derived protein

Harbinger_derived_prot

Family

6,778

false

The majority of members of this family are from plants, including putative members of the PIF/Ping-Pong family [ , ].

[]

0

[ "PFAM" ]

[ "PF04827" ]

[ "Plant_tran" ]

[ 6778 ]

1

[]

0

[]

0

[ "PUB00033672", "PUB00033674" ]

[ "11675493", "12520303" ]

[ "P instability factor: an active maize transposon system associated with the amplification of Tourist-like MITEs and a new superfamily of transposases.", "The plant MITE mPing is mobilized in anther culture." ]

[ 2001, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6778 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 67, 9 ]

3

true

Family

Harbinger transposase-derived protein

Harbinger_derived_prot

9

IPR006913

6,913

CENP-V/GFA domain

CENP-V/GFA

Domain

49,241

false

Centromere protein (CENP)-V is a kinetochore protein that drives the progression of mitosis by coordinating chromatin condensation, positioning of sister chromatid centromeres and targeting of the chromosome passenger complex (CPC), a machinery that regulates the attachment of spindle microtubules (MTs) to kinetochores...

[ "GO:0016846" ]

[ "carbon-sulfur lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF04828", "PS51891" ]

[ "GFA", "CENP_V_GFA" ]

[ 48297, 47425 ]

2

[ "EC", "METACYC" ]

[ "4.4.1.22", "PWY-1801" ]

[ "EC:4.4.1.22", "METACYC:PWY-1801" ]

2

[ "1x6m", "1xa8", "3fac", "8ajq" ]

4

[ "PUB00032333", "PUB00056760", "PUB00094769" ]

[ "15548539", "18772885", "19930468" ]

[ "A dynamic zinc redox switch.", "CENP-V is required for centromere organization, chromosome alignment and cytokinesis.", "Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction." ]

[ 2005, 2008, 2009 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Mimiviridae", "unclassified sequences" ]

[ 30759, 18123, 4, 355 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea...

[ 4, 2, 1, 4, 1, 8, 3, 1, 1, 12 ]

10

true

Domain

CENP-V/GFA domain

CENP-V/GFA

8

IPR006915

6,915

Domain of unknown function DUF637, haemagglutinin putative

DUF637_hemagglutn_put

Domain

1,337

false

This entry represents a conserved region found in a bacterial proteins which may be hemagglutinins or hemolysins.

[]

0

[ "PFAM" ]

[ "PF04830" ]

[ "DUF637" ]

[ 1337 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Mimivirus LCMiAC01", "ecological metagenomes" ]

[ 1328, 4, 1, 4 ]

4

[]

0

true

Domain

Domain of unknown function DUF637, haemagglutinin putative

DUF637_hemagglutn_put

2

IPR006916

6,916

POPDC1-3

Family

4,415

false

This entry represents the POPDC family of proteins, also known as the Popeye (POP) family, which includes POPDC1, 2 and 3 and is mainly restricted to vertebrates. It is preferentially expressed in developing and adult striated muscle [ ]. These proteins act as cAMP effectors [ , , ] and play a role in cardiac pacemakin...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR12101" ]

[ "" ]

[ 4415 ]

1

[]

0

[]

0

[ "PUB00008654", "PUB00155276", "PUB00155277", "PUB00155278", "PUB00155279", "PUB00155280", "PUB00155281", "PUB00155282" ]

[ "10882522", "22354168", "30863095", "31119192", "36624536", "36843357", "38689644", "31610034" ]

[ "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart.", "Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.", "Ten years of research on the role of BVES/ POPDC1 in human disease: a review.", "Muscular ...

[ 2000, 2012, 2019, 2019, 2023, 2023, 2024, 2019 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 105, 4302, 8 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 5, 6, 13 ]

5

true

Family

POPDC1-3

1

IPR006918

6,918

COBRA

Family

4,596

false

This entry COBRA family proteins. In Arabidopsis thaliana, members of the family are all extracellular glycosyl-phosphatidyl inositol-anchored proteins (GPI-linked) [ ]. COBRA is involved in determining the orientation of cell expansion, probably by playing an important role in cellulose deposition. It may act by recru...

[ "GO:0010215", "GO:0016020" ]

[ "cellulose microfibril organization", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF038122", "PTHR31673" ]

[ "COBRA", "" ]

[ 3626, 4524 ]

2

[]

0

[]

0

[ "PUB00044727", "PUB00044728" ]

[ "15849274", "15375203" ]

[ "COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation.", "Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Streptophyta" ]

[ 4596 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 21, 40 ]

3

true

Family

COBRA

8

IPR006920

6,920

Poxvirus A9

Poxvirus_A9

Family

147

false

This entry represents a family of Chordopoxvirus A9 proteins. Chordopoxvirus belongs to the family Poxviridae and is the cause of vertebrate infections [ ].

[]

0

[ "PFAM" ]

[ "PF04835" ]

[ "Pox_A9" ]

[ 147 ]

1

[]

0

[]

0

[ "PUB00043400" ]

[ "17848071" ]

[ "Poxviruses and the passive quest for novel hosts." ]

[ 2007 ]

1

[]

0

null

[ "Poxviridae", "Trichomonas vaginalis (strain ATCC PRA-98 / G3)" ]

[ 144, 3 ]

2

[]

0

true

Family

Poxvirus A9

Poxvirus_A9

1

IPR006921

6,921

Interferon-related developmental regulator, C-terminal

Interferon-rel_develop_reg_C

Domain

3,577

false

This entry represents the C-terminal domain of IFRD1 and similar sequences predominantly found in animals. Interferon-related developmental regulator (IFRD1) is the human homologue of the Rattus norvegicus early response protein PC4 and its murine homologue TIS7 [ ]. IFRD1 is a transcriptional coactivator/repressor con...

[]

0

[ "PFAM" ]

[ "PF04836" ]

[ "IFRD_C" ]

[ 3577 ]

1

[]

0

[ "6mtc", "6xu6" ]

2

[ "PUB00008660", "PUB00010173", "PUB00090213", "PUB00103871" ]

[ "9722946", "9050919", "26391411", "30355441" ]

[ "Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.", "The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chrom...

[ 1998, 1997, 2016, 2018 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3577 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 1, 3, 1, 10, 5, 7 ]

7

true

Domain

Interferon-related developmental regulator, C-terminal

Interferon-rel_develop_reg_C

8

IPR006923

6,923

Baculoviridae late expression factor 5, N-terminal

Baculo_LEF5_N

Domain

149

false

This is the N-terminal domain of Baculoviridae late expression factor 5, required for late and very late gene expression.

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04838" ]

[ "Baculo_LEF5" ]

[ 149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 149 ]

1

[]

0

true

Domain

Baculoviridae late expression factor 5, N-terminal

Baculo_LEF5_N

8

IPR006924

6,924

Small ribosomal subunit protein cS23-like

Ribosomal_cS23-like

Family

1,602

false

This small acidic protein is found in 30S ribosomal subunit of cyanobacteria and plant plastids. In plants it has been named plastid-specific ribosomal protein 3 (PSRP-3), and in cyanobacteria it is named Ycf65, with both also known as small ribosomal subunit protein cS23. Plastid-specific ribosomal proteins may mediat...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF04839", "PTHR35108" ]

[ "PSRP-3_Ycf65", "" ]

[ 1592, 1591 ]

2

[]

0

[ "2kt9", "5mmj", "5mmm", "5x8p", "5x8r" ]

5

[ "PUB00008661" ]

[ "10874039" ]

[ "The plastid ribosomal proteins. Identification of all the proteins in the 30 S subunit of an organelle ribosome (chloroplast)." ]

[ 2000 ]

1

[]

[ "IPR057257" ]

0

1

0

[ "Cyanobacteriota", "Eukaryota" ]

[ 360, 1242 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 3, 5 ]

3

true

Family

Small ribosomal subunit protein cS23-like

Ribosomal_cS23-like

4

IPR006925

6,925

Vps16, C-terminal

Vps16_C

Domain

6,056

false

Vps16 forms part of the Class C vacuolar protein sorting (Vps) complex. It is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [ ]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential ...

[ "GO:0006886", "GO:0005737" ]

[ "intracellular protein transport", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04840" ]

[ "Vps16_C" ]

[ 6056 ]

1

[ "REACTOME" ]

[ "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9754560" ]

1

[ "4bx9", "4kmo", "5buz", "5bv0", "5bv1", "7zu0", "8dit", "8qx8" ]

8

[ "PUB00008662", "PUB00008663", "PUB00088227", "PUB00097428" ]

[ "11702788", "11422941", "23840694", "25783203" ]

[ "VACUOLELESS1 is an essential gene required for vacuole formation and morphogenesis in Arabidopsis.", "The class C Vps complex functions at multiple stages of the vacuolar transport pathway.", "Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein...

[ 2001, 2001, 2013, 2015 ]

4

[]

0

null

[ "Eukaryota", "marine metagenome" ]

[ 6055, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 3, 8, 6, 1, 3, 16, 1, 1, 5 ]

12

true

Domain

Vps16, C-terminal

Vps16_C

6

IPR006926

6,926

Vps16, N-terminal

Vps16_N

Domain

5,155

false

This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [ ]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play ...

[ "GO:0006886", "GO:0005737" ]

[ "intracellular protein transport", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04841" ]

[ "Vps16_N" ]

[ 5155 ]

1

[ "REACTOME" ]

[ "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9754560" ]

1

[ "7zu0", "8dit", "8qx8" ]

3

[ "PUB00008662", "PUB00008663" ]

[ "11702788", "11422941" ]

[ "VACUOLELESS1 is an essential gene required for vacuole formation and morphogenesis in Arabidopsis.", "The class C Vps complex functions at multiple stages of the vacuolar transport pathway." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5155 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 2, 4, 5, 1, 4, 6, 1, 1, 5 ]

12

true

Domain

Vps16, N-terminal

Vps16_N

2

IPR006927

6,927

Protein of unknown function DUF639

DUF639

Family

3,016

false

The sequences in this family are plant proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF04842" ]

[ "DUF639" ]

[ 3016 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3016 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 35, 20, 35 ]

3

true

Family

Protein of unknown function DUF639

DUF639

1

IPR006928

6,928

Herpesvirus large tegument protein, USP domain

Herpes_teg_USP

Domain

3,003

false

All herpesviruses contain a Ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within their large tegument protein. The herpesvirus tegument ubiquitin (Ub)-specific protease (htUSP) domain of ~200 amino acids adopts an α-β-α sandwich fold that features a central catalytic cleft, ideally suited to accommoda...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04843", "PS51521" ]

[ "Herpes_teg_N", "HTUSP" ]

[ 2992, 1296 ]

2

[ "EC", "EC", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "3.4.22.-", "R-HSA-9609690", "R-HSA-9610379" ]

[ "EC:3.4.19.12", "EC:3.4.22.-", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

4

[ "2j7q", "5zz8", "6cgr", "6m6g", "6m6h", "6odm", "6ppb", "6pph", "6w2d", "6w2e", "7bqx", "7br7", "7et3", "7etj", "7eto", "8add", "8tep", "8tes", "8tet", "8teu", "8tew", "9no1" ]

22

[ "PUB00047814", "PUB00074645", "PUB00074646", "PUB00074647", "PUB00074648" ]

[ "17349955", "16306630", "17634221", "19640989", "19759126" ]

[ "Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.", "A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.", "A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherp...

[ 2007, 2005, 2007, 2009, 2009 ]

5

[]

0

null

[ "Eukaryota", "Herpesvirales", "Mycobacterium kansasii" ]

[ 1715, 1287, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens" ]

[ 10, 5, 1 ]

3

true

Domain

Herpesvirus large tegument protein, USP domain

Herpes_teg_USP

2

IPR006930

6,930

Herpesvirus pp38 phosphoprotein

Herpes_pp38

Family

62

false

Members of this family contain a conserved region found in most herpesvirus pp38 phosphoproteins.

[]

0

[ "PFAM" ]

[ "PF04846" ]

[ "Herpes_pp38" ]

[ 62 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaherpesvirinae" ]

[ 62 ]

1

[]

0

true

Family

Herpesvirus pp38 phosphoprotein

Herpes_pp38

3

IPR006931

6,931

Calcipressin

Family

5,835

false

Calcipressins (RCANs) are a novel family of calcineurin regulators that have been suggested as key factors contributing to Down syndrome in humans. Three human calcipressins have been identified, calcipressin 1-3. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syn...

[ "GO:0019722" ]

[ "calcium-mediated signaling" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04847", "PTHR10300" ]

[ "Calcipressin", "" ]

[ 5826, 5739 ]

2

[ "REACTOME" ]

[ "R-HSA-9692916" ]

[ "REACTOME:R-HSA-9692916" ]

1

[ "1wey", "6uuq" ]

2

[ "PUB00044052", "PUB00084625" ]

[ "12942079", "19273587" ]

[ "Calcium-independent calcineurin regulation.", "Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast." ]

[ 2003, 2009 ]

2

[]

[ "IPR016523" ]

0

1

0

[ "Eukaryota" ]

[ 5835 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 9, 2, 15, 11, 1, 14, 1, 1 ]

9

true

Family

Calcipressin

6

IPR006932

6,932

Holliday junction resolvase, A22

HJ-resolvase_A22

Family

230

false

This family representis the Poxvirus A22 protein, a Holliday junction resolvase also known as Resolvase OPG149, and similar proteins from poxvirus. It specifically cleaves and resolves four-way DNA Holliday junctions into linear duplex products [ , , ].

[ "GO:0000287", "GO:0000400", "GO:0016788", "GO:0006281", "GO:0006310" ]

[ "magnesium ion binding", "four-way junction DNA binding", "hydrolase activity, acting on ester bonds", "DNA repair", "DNA recombination" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "PFAM" ]

[ "PF04848" ]

[ "Pox_A22" ]

[ 230 ]

1

[]

0

[ "5e6f", "6p7a", "6p7b" ]

3

[ "PUB00066839", "PUB00066840", "PUB00066841" ]

[ "10890916", "11413313", "16781759" ]

[ "Bacterial-type DNA holliday junction resolvases in eukaryotic viruses.", "Repression of vaccinia virus Holliday junction resolvase inhibits processing of viral DNA into unit-length genomes.", "DNA cleavage by the A22R resolvase of vaccinia virus." ]

[ 2000, 2001, 2006 ]

3

[]

0

null

[ "Eukaryota", "Lysinibacillus sphaericus", "Viruses", "viral metagenome" ]

[ 11, 1, 151, 67 ]

4

[]

0

true

Family

Holliday junction resolvase, A22

HJ-resolvase_A22

1

IPR006933

6,933

HAP1, N-terminal

HAP1_N

Domain

6,538

false

This entry represents a N-terminal conserved region found in huntingtin-associated protein 1 (HAP1), trafficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and similar proteins from animals [ ]. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner [ , , ]. It is involved in...

[]

0

[ "PFAM", "SMART" ]

[ "PF04849", "SM01424" ]

[ "HAP1_N", "HAP1_N" ]

[ 6499, 6270 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9013419", "R-DME-9013425", "R-HSA-6802952", "R-HSA-9013419", "R-HSA-9013425", "R-MMU-9013419", "R-MMU-9013425", "R-RNO-9013419" ]

[ "REACTOME:R-DME-9013419", "REACTOME:R-DME-9013425", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-9013419", "REACTOME:R-HSA-9013425", "REACTOME:R-MMU-9013419", "REACTOME:R-MMU-9013425", "REACTOME:R-RNO-9013419" ]

8

[ "9dgv" ]

1

[ "PUB00019668", "PUB00019669", "PUB00019670", "PUB00094282", "PUB00094283", "PUB00094284", "PUB00094285" ]

[ "7477378", "9599014", "9285789", "23395375", "22731248", "19262167", "27737633" ]

[ "A huntingtin-associated protein enriched in brain with implications for pathology.", "HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.", "Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exc...

[ 1995, 1998, 1997, 2013, 2012, 2009, 2016 ]

7

[]

0

null

[ "Eukaryota" ]

[ 6538 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 47, 5, 18, 18, 17 ]

6

true

Domain

HAP1, N-terminal

HAP1_N

2

IPR006934

6,934

Baculovirus ODV-E66, C-terminal domain

ODV-E66_C_baculovirus

Domain

199

false

This entry represents the C-terminal domain of Non-sulfated chondroitin lyase E66 from Autographa californica nuclear polyhedrosis virus (ODV-E66) and similar sequences from baculovirus. This domain, predominantly formed by β-strands, is often found associated with . ODV-E66 is a component of the polyhedra envelope tha...

[ "GO:0019031" ]

[ "viral envelope" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04850" ]

[ "Baculo_E66" ]

[ 199 ]

1

[]

0

[ "3vsm", "3vsn" ]

2

[ "PUB00008001", "PUB00152765", "PUB00152766" ]

[ "9108103", "21440017", "21715327" ]

[ "N-terminal sequences from Autographa californica nuclear polyhedrosis virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct reporter proteins to the nuclear envelope, intranuclear microvesicles and the envelope of occlusion derived virus.", "Autographa californica multiple nucleopolyhedrovirus odv...

[ 1997, 2011, 2011 ]

3

[]

0

null

[ "Ceutorhynchus assimilis", "Viruses" ]

[ 1, 198 ]

2

[]

0

true

Domain

Baculovirus ODV-E66, C-terminal domain

ODV-E66_C_baculovirus

4

IPR006935

6,935

Helicase/UvrB, N-terminal

Helicase/UvrB_N

Domain

108,265

false

This entry represents a domain found in the N terminus of several proteins, including helicases, the R subunit (HsdR) of type I restriction endonucleases ( ), the Res subunit of type III endonucleases ( ), and the B subunit of the UvrABC system (UvrB) [ , , ].

[ "GO:0003677", "GO:0005524", "GO:0016787" ]

[ "DNA binding", "ATP binding", "hydrolase activity" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF04851" ]

[ "ResIII" ]

[ 108265 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-113418", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-72086", "R-BTA-73762", "R-BTA-73772", "R-BTA-73776", "R-BTA-73779", "R-BTA-73863", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042", "R-BTA-77075"...

[ "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-73762", "REACTOME:R-BTA-73772", "REACTOME:R-BTA-...

183

[ "1c4o", "1d2m", "1d9x", "1d9z", "1rif", "1t5l", "2d7d", "2fdc", "2fwr", "2fz4", "2gjk", "2gk6", "2gk7", "2nmv", "2oca", "2wjv", "2wjy", "2xzo", "2xzp", "3b6e", "3h1t", "3uwx", "3v4r", "4gl2", "4xqk", "4zcf", "5ffj", "5fmf", "5ivw", "5iy6", "5iy7", "5iy8"...

152

[ "PUB00008667", "PUB00008668", "PUB00035713" ]

[ "11178902", "9628345", "16125908" ]

[ "Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I.", "Functional analysis of conserved motifs in type III restriction-modification enzymes.", "The uvrA gene is involved in oxidative and acid stress responses in Lactobacillus helveticus CNBL1156." ]

[ 2001, 1998, 2005 ]

3

[ "IPR014001" ]

[ "IPR044749" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2986, 80957, 18669, 3497, 2156 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 19, 2, 7, 4, 3, 31, 18, 5, 13, 16, 3, 5, 75 ]

13

true

Domain

Helicase/UvrB, N-terminal

Helicase/UvrB_N

2

IPR006936

6,936

ALOG domain

ALOG_dom

Domain

6,085

false

The 125-residue ALOG (Arabidopsis LSH1 and oryza G1) domain is rich in basic amino acids, especially arginine, and is highly conserved among land plants. Members of the ALOG family of proteins function as key developmental regulators. It has been proposed that the ALOG domain originated from the N- terminal DNA-binding...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04852", "PS51697" ]

[ "ALOG_dom", "ALOG" ]

[ 6002, 5976 ]

2

[]

0

[ "8p5q" ]

1

[ "PUB00072583", "PUB00072584" ]

[ "19901325", "23146749" ]

[ "The homeotic gene long sterile lemma (G1) specifies sterile lemma identity in the rice spikelet.", "ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons." ]

[ 2009, 2012 ]

2

[]

0

null

[ "Eukaryota", "Huberarchaeum crystalense", "Pseudomonadati" ]

[ 6082, 1, 2 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 34, 24, 59 ]

3

true

Domain

ALOG domain

ALOG_dom

2

IPR006938

6,938

Protein of unknown function DUF624

DUF624

Family

6,804

false

This family consists of uncharacterised or hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF04854" ]

[ "DUF624" ]

[ 6804 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 6768, 2, 14, 20 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF624

DUF624

2

IPR006939

6,939

SNF5/SMARCB1/INI1

SNF5

Family

7,038

false

SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterised so far [ ]. This family consists of the conserved region of SNF5, including a direc...

[ "GO:0006338", "GO:0000228" ]

[ "chromatin remodeling", "nuclear chromosome" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04855" ]

[ "SNF5" ]

[ 7038 ]

1

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp2081", "GenProp2084", "R-BTA-3214858", "R-BTA-8939243", "R-BTA-9933937", "R-BTA-9933939", "R-BTA-9933946", "R-BTA-9934037", "R-GGA-8939243", "R-GGA-9933937", "R-GGA-9933939", "R-GGA-9933946", "R-GGA-9934037", "R-HSA-3214858", "R-HSA-8939243", "R-HSA-9824585", "R-HSA-9845323",...

[ "GP:GenProp2081", "GP:GenProp2084", "REACTOME:R-BTA-3214858", "REACTOME:R-BTA-8939243", "REACTOME:R-BTA-9933937", "REACTOME:R-BTA-9933939", "REACTOME:R-BTA-9933946", "REACTOME:R-BTA-9934037", "REACTOME:R-GGA-8939243", "REACTOME:R-GGA-9933937", "REACTOME:R-GGA-9933939", "REACTOME:R-GGA-9933946"...

29

[ "5gjk", "5l7a", "5l7b", "6ax5", "6k15", "6kag", "6kw3", "6kw4", "6kw5", "6kz7", "6l9j", "6lth", "6ltj", "6lzp", "6tda", "6uxv", "6uxw", "6v8o", "6v92", "7c4j", "7eg6", "7egm", "7egp", "7vdv", "7y8r" ]

25

[ "PUB00008669", "PUB00008670", "PUB00008671" ]

[ "10325430", "11390659", "9671307" ]

[ "Identification and analysis of the Arabidopsis thaliana BSH gene, a member of the SNF5 gene family.", "Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo.", "Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer." ]

[ 1999, 2001, 1998 ]

3

[]

[ "IPR017393" ]

0

1

0

[ "Eukaryota" ]

[ 7038 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 5, 1, 6, 6, 2, 4, 6, 2, 2, 6 ]

12

true

Family

SNF5/SMARCB1/INI1

SNF5

7

IPR006940

6,940

Securin sister-chromatid separation inhibitor

Securin_separation_inhibitor

Family

1,105

false

Securin, also known as pituitary tumour-transforming gene product is a regulatory protein which plays a central role in chromosome stability in the p53/TP53 pathway, and in DNA repair. It probably acts by blocking the action of key proteins, for example, during mitosis it blocks Separase/ESPL1 function preventing the p...

[ "GO:0051276", "GO:0005634", "GO:0005737" ]

[ "chromosome organization", "nucleus", "cytoplasm" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF04856", "PTHR10418" ]

[ "Securin", "" ]

[ 971, 1016 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-174154", "R-HSA-174178", "R-HSA-2467813", "R-MMU-174154", "R-MMU-174178", "R-MMU-2467813", "R-RNO-174154", "R-RNO-174178", "R-RNO-2467813" ]

[ "REACTOME:R-HSA-174154", "REACTOME:R-HSA-174178", "REACTOME:R-HSA-2467813", "REACTOME:R-MMU-174154", "REACTOME:R-MMU-174178", "REACTOME:R-MMU-2467813", "REACTOME:R-RNO-174154", "REACTOME:R-RNO-174178", "REACTOME:R-RNO-2467813" ]

9

[ "5u1s", "5u1t", "7nj1" ]

3

[ "PUB00008672" ]

[ "10411507" ]

[ "Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis." ]

[ 1999 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1105 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 8, 5, 4, 1, 1 ]

7

true

Family

Securin sister-chromatid separation inhibitor

Securin_separation_inhibitor

9

IPR006941

6,941

Ribonuclease CAF1

RNase_CAF1

Family

18,054

false

The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly(A) tail. CAF1 (also known as CCR4-associated factor 1) is an RNase of the DEDD superfamily, and a subunit of the CCR4-NOT complex that mediates 3' to 5' mRNA deadenylation [ , ]. In yeast, CAF1 ( ) is also known as POP2, and encodes ...

[]

0

[ "PFAM" ]

[ "PF04857" ]

[ "CAF1" ]

[ 18054 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.13.4", "R-BTA-429947", "R-BTA-6804115", "R-DRE-6804115", "R-GGA-429947", "R-GGA-6804115", "R-HSA-380994", "R-HSA-429947", "R-HSA-450604", "R-HSA-6804115", "R-HSA-9820841", "R-MMU-429947", "R-MMU-450604", "R-MMU-6804115", "R-XTR-429947", "R-XTR-6804115" ]

[ "EC:3.1.13.4", "REACTOME:R-BTA-429947", "REACTOME:R-BTA-6804115", "REACTOME:R-DRE-6804115", "REACTOME:R-GGA-429947", "REACTOME:R-GGA-6804115", "REACTOME:R-HSA-380994", "REACTOME:R-HSA-429947", "REACTOME:R-HSA-450604", "REACTOME:R-HSA-6804115", "REACTOME:R-HSA-9820841", "REACTOME:R-MMU-429947",...

16

[ "1uoc", "2a1r", "2a1s", "2d5r", "2p51", "3d45", "3g0z", "3g10", "4b8a", "4b8c", "4gmj", "7ax1", "7voi", "9e7t", "9e7u" ]

15

[ "PUB00019239", "PUB00019241", "PUB00082302", "PUB00082305", "PUB00082306", "PUB00082307", "PUB00082309", "PUB00082310" ]

[ "11239395", "14618157", "11410650", "15215893", "15769875", "23388391", "15247430", "20379136" ]

[ "The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.", "X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex.", "The yeast POP2 gene encodes a nuclease involved in m...

[ 2001, 2003, 2001, 2004, 2005, 2013, 2004, 2010 ]

8

[]

[ "IPR039637" ]

0

1

0

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 6, 18047, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 52, 3, 22, 7, 39, 19, 2, 36, 33, 1, 2, 69 ]

12

true

Family

Ribonuclease CAF1

RNase_CAF1

5

IPR006942

6,942

TH1 protein

TH1

Family

2,664

false

TH1 is a highly conserved but uncharacterised metazoan protein. No homologue has been identified in Caenorhabditis elegans [ ]. TH1 binds specifically to A-Raf kinase [ ].

[ "GO:0045892", "GO:0005634" ]

[ "negative regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04858", "PTHR12144" ]

[ "TH1", "" ]

[ 2603, 2582 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-112382", "R-DME-113418", "R-DME-674695", "R-DME-6796648", "R-DME-75955", "R-HSA-112382", "R-HSA-113418", "R-HSA-167152", "R-HSA-167158", "R-HSA-167200", "R-HSA-167238", "R-HSA-167242", "R-HSA-167243", "R-HSA-167246", "R-HSA-167287", "R-HSA-167290", "R-HSA-674695", "R-HSA-679...

[ "REACTOME:R-DME-112382", "REACTOME:R-DME-113418", "REACTOME:R-DME-674695", "REACTOME:R-DME-6796648", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-113418", "REACTOME:R-HSA-167152", "REACTOME:R-HSA-167158", "REACTOME:R-HSA-167200", "REACTOME:R-HSA-167238", "REACTOME:R-HSA-167...

29

[ "5l3x", "6gml", "7pks", "7ycx", "8jj6", "8rbx", "8uha", "8uhd", "8uhg", "8ui0", "8uis", "8w8e", "9j0n", "9j0o", "9j0p", "9vd9" ]

16

[ "PUB00008673", "PUB00008674" ]

[ "11030415", "11952167" ]

[ "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.", "Identification of TH1 as an interaction partner of A-Raf kinase." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2664 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4, 2, 3 ]

5

true

Family

TH1 protein

TH1

1

IPR006943

6,943

Domain of unknown function DUF641, plant

DUF641_pln

Domain

3,840

false

This conserved region is found in a number of plant proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF04859" ]

[ "DUF641" ]

[ 3840 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Tracheophyta" ]

[ 3840 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 53, 24, 22 ]

3

true

Domain

Domain of unknown function DUF641, plant

DUF641_pln

2

IPR006944

6,944

Bacteriophage/Gene transfer agent portal protein

Phage/GTA_portal

Family

18,101

false

This is a family of bacteriophage, prophage and Gene Transfer Agent (GTA) portal proteins. Positioned at one of the twelve icosahedral vertices, of the viral capsid, is a dodecameric complex of the virus encoded portal protein. This dodecameric complex, known as the portal or connector complex, forms the channel throug...

[]

0

[ "PFAM" ]

[ "PF04860" ]

[ "Phage_portal" ]

[ 18101 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "3kdr", "6tba", "6te8", "6te9", "6to8", "6toa", "6tui", "8cez", "8fql", "8fwb", "8fwe", "8fxr", "8hqo", "8q7d", "8qek", "8qem", "8qje", "8r69", "9ilp", "9imv", "9lbn", "9lw9" ]

22

[ "PUB00008675" ]

[ "11839289" ]

[ "DNA packaging: a new class of molecular motors." ]

[ 2002 ]

1

[]

[ "IPR006427", "IPR006430" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 57, 15421, 34, 2159, 430 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bacteriophage/Gene transfer agent portal protein

Phage/GTA_portal

1

IPR006946

6,946

DUF642 L-galactono-1,4-lactone-responsive gene 2-like domain

DGR2-like_dom

Domain

5,213

false

This entry represents a domain found twice in the protein DUF642 L-galactono-1,4-lactone-responsive gene 2 from Arabidopsis thaliana (DGR2) and similar proteins found in plants and bacteria. DGR2 is involved in the regulation of testa rupture during seed germination [ ] and in the development of roots and rosettes [ ]....

[]

0

[ "PFAM" ]

[ "PF04862" ]

[ "DUF642" ]

[ 5213 ]

1

[]

0

[]

0

[ "PUB00101375", "PUB00101376" ]

[ "31284602", "22323769" ]

[ "Overview of the Role of Cell Wall DUF642 Proteins in Plant Development.", "Analysis of two L-Galactono-1,4-lactone-responsive genes with complementary expression during the development of Arabidopsis thaliana." ]

[ 2019, 2012 ]

2

[]

[ "IPR027576" ]

0

1

0

[ "Bacteria", "Eukaryota", "Nitrosopumilus adriaticus", "metagenomes" ]

[ 914, 4290, 1, 8 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 41, 39, 47 ]

3

true

Domain

DUF642 L-galactono-1,4-lactone-responsive gene 2-like domain

DGR2-like_dom

4

IPR006947

6,947

Alliinase, EGF-like domain

EGF_alliinase

Domain

1,099

false

Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulphoxide cysteine derivatives by alliinase, whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a...

[ "GO:0016846" ]

[ "carbon-sulfur lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04863" ]

[ "EGF_alliinase" ]

[ 1099 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.4.1.4", "PWY-5706", "PWY-5707", "PWY-5708", "PWY-6539", "PWY-6900", "PWY-7614" ]

[ "EC:4.4.1.4", "METACYC:PWY-5706", "METACYC:PWY-5707", "METACYC:PWY-5708", "METACYC:PWY-6539", "METACYC:PWY-6900", "METACYC:PWY-7614" ]

7

[ "1lk9", "2hor", "2hox" ]

3

[ "PUB00008677" ]

[ "12235163" ]

[ "The active principle of garlic at atomic resolution." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1099 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 5, 9 ]

3

true

Domain

Alliinase, EGF-like domain

EGF_alliinase

8

IPR006948

6,948

Alliinase, C-terminal

Alliinase_C

Domain

3,367

false

Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulphoxide cysteine derivatives by alliinase, whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a...

[ "GO:0016846" ]

[ "carbon-sulfur lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04864" ]

[ "Alliinase_C" ]

[ 3367 ]

1

[ "EC", "GP" ]

[ "2.6.1", "GenProp1464" ]

[ "EC:2.6.1", "GP:GenProp1464" ]

2

[ "1lk9", "2hor", "2hox", "3bwn", "3bwo" ]

5

[ "PUB00008677" ]

[ "12235163" ]

[ "The active principle of garlic at atomic resolution." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 13, 3349, 5 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 24, 9, 34 ]

3

true

Domain

Alliinase, C-terminal

Alliinase_C

6

IPR006949

6,949

Baseplate protein J-like, barrel domain

Barrel_Baseplate_J-like

Domain

8,560

false

The temperate bacteriophage P2 has four defined tail genes: V, J, W and I. Their order is the late gene promoter, VWJI, followed by the tail fibre genes H and G and then a transcription terminator. BAP V protein is the small spike at the tip of the tail and basal plate assembly protein J lies at the edge of the basepla...

[]

0

[ "PFAM" ]

[ "PF04865" ]

[ "Baseplate_J" ]

[ 8560 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "8env", "8eon", "8kea", "8v3w", "8v41", "8v43", "9b45", "9euf", "9eug", "9euh", "9eui", "9euj", "9euk", "9g8s", "9gb2", "9ki1" ]

16

[ "PUB00008577" ]

[ "7483254" ]

[ "Bacteriophage P2: genes involved in baseplate assembly." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 50, 7787, 20, 648, 55 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Baseplate protein J-like, barrel domain

Barrel_Baseplate_J-like

9

IPR006950

6,950

Rotavirus non-structural protein 6

Rotavirus_NSP6

Family

516

false

This family comprises the 11kDa non-structural proteins found in segment S11 of the Rotavirus genome. They may form part of a complex that is involved in the replication of the genome.

[]

0

[ "PFAM" ]

[ "PF04866" ]

[ "Rota_NS6" ]

[ 516 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rotavirus" ]

[ 516 ]

1

[]

0

true

Family

Rotavirus non-structural protein 6

Rotavirus_NSP6

7

IPR006951

6,951

Protein of unknown function DUF643

DUF643

Family

74

false

These are proteins of unknown function found in Borrelia burgdorferi (Lyme disease spirochete)

[]

0

[ "PFAM" ]

[ "PF04867" ]

[ "DUF643" ]

[ 74 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Borreliella", "SPHINX/BMMF group 2 DNA sequence" ]

[ 73, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF643

DUF643

1

IPR006952

6,952

Retinal cGMP phosphodiesterase, gamma subunit

PDE6_gamma

Family

2,321

false

Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit [ ], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling sys...

[ "GO:0004114", "GO:0030553", "GO:0007601" ]

[ "3',5'-cyclic-nucleotide phosphodiesterase activity", "cGMP binding", "visual perception" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF04868", "PIRSF000969", "PTHR12122" ]

[ "PDE6_gamma", "35-cGMP_Pdiase_g", "" ]

[ 2321, 1668, 2282 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.4.35", "R-BTA-2485179", "R-BTA-2514859", "R-BTA-4086398", "R-CFA-2485179", "R-CFA-2514859", "R-CFA-4086398", "R-HSA-2485179", "R-HSA-2514859", "R-HSA-4086398", "R-MMU-2485179", "R-MMU-2514859", "R-MMU-4086398" ]

[ "EC:3.1.4.35", "REACTOME:R-BTA-2485179", "REACTOME:R-BTA-2514859", "REACTOME:R-BTA-4086398", "REACTOME:R-CFA-2485179", "REACTOME:R-CFA-2514859", "REACTOME:R-CFA-4086398", "REACTOME:R-HSA-2485179", "REACTOME:R-HSA-2514859", "REACTOME:R-HSA-4086398", "REACTOME:R-MMU-2485179", "REACTOME:R-MMU-251...

13

[ "1fqj", "2ju4", "3jab", "3jbq", "3jwr", "6mzb", "7jsn", "8ufi", "8ugb", "8ugs", "8ulg", "9cxg", "9cxh", "9cxi", "9cxj" ]

15

[ "PUB00008678", "PUB00008679" ]

[ "11900530", "11502744" ]

[ "Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains.", "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human...

[ 2002, 2001 ]

2

[]

0

null

[ "Bilateria" ]

[ 2321 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 8, 6 ]

4

true

Family

Retinal cGMP phosphodiesterase, gamma subunit

PDE6_gamma

5

IPR006953

6,953

Vesicle tethering protein Uso1/P115-like, head domain

Vesicle_Uso1_P115_head

Domain

5,346

false

This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associated protein (TAP) or Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal aci...

[ "GO:0006886", "GO:0048280", "GO:0000139", "GO:0005737" ]

[ "intracellular protein transport", "vesicle fusion with Golgi apparatus", "Golgi membrane", "cytoplasm" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF04869" ]

[ "Uso1_p115_head" ]

[ 5346 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-204005", "R-BTA-6807878", "R-DME-204005", "R-DME-6807878", "R-HSA-162658", "R-HSA-204005", "R-HSA-6807878", "R-MMU-204005", "R-MMU-6807878", "R-RNO-204005", "R-RNO-6807878", "R-SCE-204005", "R-SCE-6807878", "R-SPO-204005", "R-SPO-6807878" ]

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-6807878", "REACTOME:R-DME-204005", "REACTOME:R-DME-6807878", "REACTOME:R-HSA-162658", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-6807878", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-6807878", "REACTOME:R-RNO-204005", "REACTOME:R-RNO-6807878", "REACTOME:R-SC...

15

[ "2w3c", "3gq2", "3grl", "6lst", "6lsu" ]

5

[ "PUB00008680" ]

[ "11927603" ]

[ "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115." ]

[ 2002 ]

1

[]

0

null

[ "Ciceribacter ferrooxidans", "Eukaryota" ]

[ 1, 5345 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 6, 3, 1, 1, 1, 3, 6, 1, 1, 30 ]

12

true

Domain

Vesicle tethering protein Uso1/P115-like, head domain

Vesicle_Uso1_P115_head

5

IPR006954

6,954

Moulting cycle mlt-10-like

Mlt-10-like

Family

1,497

false

This entry represents a family of proteins from nematodes, including Molting protein mlt-10 from Caenorhabditis elegans. Mlt-10 plays a role in the moulting cycle, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle [ ].

[]

0

[ "PFAM" ]

[ "PF04870" ]

[ "Moulting_cycle" ]

[ 1497 ]

1

[]

0

[]

0

[ "PUB00057485" ]

[ "20335506" ]

[ "MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans." ]

[ 2010 ]

1

[]

0

null

[ "Nematoda" ]

[ 1497 ]

1

[ "Caenorhabditis elegans" ]

[ 14 ]

1

true

Family

Moulting cycle mlt-10-like

Mlt-10-like

4

IPR006955

6,955

Uso1/p115-like vesicle tethering protein, C-terminal

Uso1_p115_C

Domain

4,070

false

This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein. This myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal aci...

[ "GO:0006886", "GO:0016192" ]

[ "intracellular protein transport", "vesicle-mediated transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF04871" ]

[ "Uso1_p115_C" ]

[ 4070 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-204005", "R-BTA-6807878", "R-DME-204005", "R-DME-6807878", "R-HSA-162658", "R-HSA-204005", "R-HSA-6807878", "R-MMU-204005", "R-MMU-6807878", "R-RNO-204005", "R-RNO-6807878", "R-SCE-204005", "R-SCE-6807878" ]

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-6807878", "REACTOME:R-DME-204005", "REACTOME:R-DME-6807878", "REACTOME:R-HSA-162658", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-6807878", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-6807878", "REACTOME:R-RNO-204005", "REACTOME:R-RNO-6807878", "REACTOME:R-SC...

13

[]

0

[ "PUB00008680", "PUB00009038" ]

[ "11927603", "12077354" ]

[ "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.", "Vesicle tethering complexes in membrane traffic." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4070 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 6, 1, 1, 1, 1, 3, 6, 1, 42 ]

11

true

Domain

Uso1/p115-like vesicle tethering protein, C-terminal

Uso1_p115_C

9

IPR006956

6,956

Poxvirus L5

Poxvirus_L5

Family

129

false

This family represents Protein L5 from variola (smallpox), vaccinia virus, and similar proteins from poxvirus. L5, also known as Entry-fusion complex protein OPG094, is a component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core int...

[]

0

[ "PFAM" ]

[ "PF04872" ]

[ "Pox_L5" ]

[ 129 ]

1

[]

0

[ "7ytt", "7ytu" ]

2

[ "PUB00008683", "PUB00034709", "PUB00103595", "PUB00103596" ]

[ "8383392", "16339313", "34076488", "16103150" ]

[ "Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments.", "Poxvirus multiprotein entry-fusion complex.", "Insights into the Organization of the Poxvirus Multicomponent Entry-Fusion Complex from Proximity Analyses in Living Infected Cells.", "The product of the vaccinia virus L5R gene ...

[ 1993, 2005, 2021, 2005 ]

4

[]

0

null

[ "Poxviridae" ]

[ 129 ]

1

[]

0

true

Family

Poxvirus L5

Poxvirus_L5

6

IPR006957

6,957

Ethylene insensitive 3

EIN3

Family

3,542

false

Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses [ ]. In the presence of ethylene, dark-grown dicotyledonous seedlings undergo dramatic morphological changes ...

[ "GO:0003700", "GO:0005634" ]

[ "DNA-binding transcription factor activity", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR33305" ]

[ "" ]

[ 3542 ]

1

[]

0

[ "1wij", "4zds" ]

2

[ "PUB00019506", "PUB00019507", "PUB00101835" ]

[ "9215635", "10508761", "26352699" ]

[ "Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins.", "The ethylene-response pathway: signal perception to gene regulation.", "Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSIT...

[ 1997, 1999, 2015 ]

3

[]

0

null

[ "Streptophyta" ]

[ 3542 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 58, 23, 29 ]

3

true

Family

Ethylene insensitive 3

EIN3

7

IPR006959

6,959

Protein of unknown function DUF645

DUF645

Family

238

false

This family contains uncharacterised proteins from Vibrio cholerae.

[]

0

[ "PFAM" ]

[ "PF04875" ]

[ "DUF645" ]

[ 238 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Vibrio" ]

[ 238 ]

1

[]

0

true

Family

Protein of unknown function DUF645

DUF645

5

IPR006960

6,960

Major non-capsid protein, tenuivirus

Major_non-capsid_tenuivirus

Family

90

false

This entry contains the tenuivirus major non-capsid protein. Proteins accumulate in large amounts in tenuivirus infected cells. They are found in the inclusion bodies that are formed after infection [ ].

[]

0

[ "PFAM" ]

[ "PF04876" ]

[ "Tenui_NCP" ]

[ 90 ]

1

[]

0

[ "7xcc", "7xcd" ]

2

[ "PUB00008685" ]

[ "8317091" ]

[ "Comparative light and electron microscopic analyses of tenuivirus major noncapsid protein (NCP) inclusion bodies in infected plants, and of the NCP in vitro." ]

[ 1993 ]

1

[]

0

null

[ "Lygus hesperus", "Phenuiviridae" ]

[ 1, 89 ]

2

[]

0

true

Family

Major non-capsid protein, tenuivirus

Major_non-capsid_tenuivirus

3

IPR006961

6,961

Harpin, HrpN/Z

HrpN/Z

Family

445

false

HrpZ (harpin elicitor) from the plant pathogen Pseudomonas syringae binds to lipid bilayers and forms a cation-conducting pore in vivo. This pore-forming activity may allow nutrient release or delivery of virulence factors during bacterial colonisation of host plants [ ].

[]

0

[ "PFAM" ]

[ "PF04877" ]

[ "Harpin" ]

[ 445 ]

1

[]

0

[]

0

[ "PUB00008686", "PUB00013011" ]

[ "11134504", "12650449" ]

[ "HrpZ(Psph) from the plant pathogen Pseudomonas syringae pv. phaseolicola binds to lipid bilayers and forms an ion-conducting pore in vitro.", "Erwinia carotovora subsp. carotovora and Erwinia-derived elicitors HrpN and PehA trigger distinct but interacting defense responses and cell death in Arabidopsis." ]

[ 2001, 2003 ]

2

[]

[ "IPR054634" ]

0

1

0

[ "Pseudomonadota" ]

[ 445 ]

1

[]

0

true

Family

Harpin, HrpN/Z

HrpN/Z

4

IPR006962

6,962

P48 protein, Baculovirus

P48_Baculovir

Family

159

false

This family comprises the Baculovirus P48 proteins. They contain two possible membrane-spanning domains and a cysteine-rich domain that are conserved in all of the proteins. The Bombyx mori (Silk moth) nuclear polyhedrosis virus protein, , has been described as a putative DNA helicase.

[]

0

[ "PFAM" ]

[ "PF04878" ]

[ "Baculo_p48" ]

[ 159 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 159 ]

1

[]

0

true

Family

P48 protein, Baculovirus

P48_Baculovir

7

IPR006963

6,963

Molybdopterin oxidoreductase, 4Fe-4S domain

Mopterin_OxRdtase_4Fe-4S_dom

Domain

93,194

false

The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [ ]. The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzym...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PFAM", "PROFILE", "SMART" ]

[ "PF04879", "PF22151", "PS51669", "SM00926" ]

[ "Molybdop_Fe4S4", "Fer4_NDSU1", "4FE4S_MOW_BIS_MGD", "Molybdop_Fe4S4" ]

[ 67638, 12112, 90335, 79127 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-DDI-6799198", "R-DDI-9837999", "R-DME-611105", "R-DME-6799198", "R-DME-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999", "R-RNO-611105", "R-RNO-6799198", "R-RNO-9837999" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9837999", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R...

17

[ "1aa6", "1fdi", "1fdo", "1h0h", "1kqf", "1kqg", "1ogy", "1q16", "1r27", "1siw", "1y4z", "1y5i", "1y5l", "1y5n", "2fug", "2iv2", "2ivf", "2jim", "2jio", "2jip", "2jiq", "2jir", "2nap", "2nya", "2v3v", "2v45", "2vpw", "2vpx", "2vpy", "2vpz", "2ybb", "3egw"...

400

[ "PUB00000608", "PUB00002890", "PUB00003788", "PUB00003854", "PUB00009739", "PUB00040815", "PUB00098489", "PUB00149919", "PUB00153614", "PUB00154099" ]

[ "2015248", "8125918", "3062312", "8022286", "9036855", "16469879", "27595392", "29395787", "27846502", "26940877" ]

[ "Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum and possible cofactor-binding domains.", "Multiple pathways of electron transfer in dimethyl sulfoxide reductase of Escherichia coli.", "Nucleotide sequence of the dmsABC operon encoding the anaerobic...

[ 1991, 1994, 1988, 1994, 1997, 2006, 2016, 2018, 2016, 2016 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Escherichia phage RCS47", "Eukaryota", "unclassified sequences" ]

[ 1894, 84612, 1, 5145, 1542 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 4, 10, 4, 3, 1, 2, 4, 9 ]

11

true

Domain

Molybdopterin oxidoreductase, 4Fe-4S domain

Mopterin_OxRdtase_4Fe-4S_dom

3

IPR006964

6,964

NUDE domain

NUDE_dom

Domain

5,238

false

This entry represents the conserved region of NUDE proteins. Proteins containing this domain are homologues of the nuclear distribution protein RO11 of Neurospora crassa. NUDE interacts with the NUDF via an N-terminal coiled coil domain; this is the only domain which is absolutely required for NUDE function.

[]

0

[ "PFAM" ]

[ "PF04880" ]

[ "NUDE_C" ]

[ 5238 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-2565942", "R-GGA-380259", "R-GGA-380270", "R-GGA-380284", "R-GGA-380320", "R-GGA-5620912", "R-GGA-5663220", "R-GGA-8854518", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-2565942", "R-HSA-380259", ...

[ "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-2565942", "REACTOME:R-GGA-380259", "REACTOME:R-GGA-380270", "REACTOME:R-GGA-380284", "REACTOME:R-GGA-380320", "REACTOME:R-GGA-5620912", "REACTOME:R-GGA-5663220", "REACTOME:R-GGA-8854518", "REACTOME:R-G...

63

[ "2v66", "2v71", "5yi4", "6kzj", "7e1t" ]

5

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5238 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 10, 4, 20, 3, 2, 11 ]

6

true

Domain

NUDE domain

NUDE_dom

2

IPR006966

6,966

Peroxin-3

Family

5,202

false

Peroxin 3 (Pex3p), also known as Peroxisomal biogenesis factor 3, has been identified and characterised as a peroxisomal membrane protein in yeasts and mammals [ ]. Two putative peroxisomal membrane-bound Pex3p homologues have also been found in Arabidopsis thaliana [ ]. They possess a membrane peroxisomal targeting si...

[ "GO:0007031", "GO:0005778" ]

[ "peroxisome organization", "peroxisomal membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04882", "PTHR28080" ]

[ "Peroxin-3", "" ]

[ 4992, 5052 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-1369062", "R-DDI-9603798", "R-HSA-1369062", "R-HSA-9603798", "R-MMU-1369062", "R-MMU-9603798", "R-RNO-1369062", "R-RNO-9603798", "R-SCE-1369062", "R-SCE-9603798", "R-SPO-9603798" ]

[ "REACTOME:R-DDI-1369062", "REACTOME:R-DDI-9603798", "REACTOME:R-HSA-1369062", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-1369062", "REACTOME:R-MMU-9603798", "REACTOME:R-RNO-1369062", "REACTOME:R-RNO-9603798", "REACTOME:R-SCE-1369062", "REACTOME:R-SCE-9603798", "REACTOME:R-SPO-9603798" ]

11

[ "3ajb", "3mk4", "9i5r" ]

3

[ "PUB00008689", "PUB00043390", "PUB00043391" ]

[ "10848631", "14733948", "10968777" ]

[ "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.", "Sorting pathway and molecular targeting signals for the Arabidopsis peroxin 3.", "PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G." ]

[ 2000, 2004, 2000 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5202 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 2, 1, 1, 3, 6, 1, 4, 4, 1, 1, 14 ]

12

true

Family

Peroxin-3

5

IPR006968

6,968

Root UVB sensitive family

RUS_fam

Family

8,186

false

This family is composed of root UVB sensitive proteins and their homologues. In Arabidopsis thaliana, proteins in this family are involved in UVB-sensing and in early seedling morphogenesis and development [ ]. In plants, these proteins play a role in auxin-transport, plant growth and development [ , ] and appears to b...

[]

0

[ "PANTHER" ]

[ "PTHR12770" ]

[ "" ]

[ 8186 ]

1

[]

0

[]

0

[ "PUB00057512", "PUB00057513", "PUB00066759", "PUB00072694", "PUB00154596" ]

[ "19515790", "20562234", "21511809", "19075229", "31268148" ]

[ "ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway.", "Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 is required for polar auxin transport.", "root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin...

[ 2009, 2010, 2011, 2008, 2019 ]

5

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 8183, 3 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 28, 9, 2, 9, 4, 1, 20, 5, 59 ]

9

true

Family

Root UVB sensitive family

RUS_fam

1

IPR006969

6,969

Stigma-specific protein Stig1-like

Stig-like

Family

3,963

false

This family represents the Stig1 cysteine rich protein and related plant proteins. The tobacco stigma-specific gene, STIG1 is developmentally regulated and expressed specifically in the stigmatic secretory zone. Pistils of transgenic STIG1-barnase tobacco plants undergo normal development, but lack the stigmatic secret...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04885", "PTHR33227" ]

[ "Stig1", "" ]

[ 3868, 3598 ]

2

[]

0

[]

0

[ "PUB00009706" ]

[ "8039494" ]

[ "Female sterile tobacco plants are produced by stigma-specific cell ablation." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 287, 3667, 6, 3 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 4, 6 ]

3

true

Family

Stigma-specific protein Stig1-like

Stig-like

2

IPR006972

6,972

Translocator protein BipB-like, C-terminal domain

BipB-like_C

Domain

2,127

false

This entry represents the C-terminal domain of Translocator protein BipB from Burkholderia pseudomallei and similar proteins predominantly found in proteobacteria. BipB plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercel...

[]

0

[ "PFAM" ]

[ "PF04888" ]

[ "SseC" ]

[ 2127 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "3wxx" ]

1

[ "PUB00008690", "PUB00009041", "PUB00053410", "PUB00085104", "PUB00151492" ]

[ "1156700", "11580752", "16159789", "18248436", "11567004" ]

[ "Theory of RNA-DNA hybridization--I. Stoichiometry at equilibrium.", "Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli.", "Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkhold...

[ 1975, 2001, 2005, 2008, 2001 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "invertebrate metagenome" ]

[ 2120, 6, 1 ]

3

[]

0

true

Domain

Translocator protein BipB-like, C-terminal domain

BipB-like_C

7

IPR006973

6,973

Pre-mRNA-splicing factor Cwf15/Cwc15

Cwf_Cwc_15

Family

4,666

false

This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologues. It is a component of a complex containing Cef1 and may be involved in pre-mRNA splicing [ ].

[ "GO:0000398", "GO:0005681" ]

[ "mRNA splicing, via spliceosome", "spliceosomal complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04889", "PTHR12718" ]

[ "Cwf_Cwc_15", "" ]

[ 4655, 4551 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-CEL-72163", "R-DME-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163", "R-SPO-72163", "R-XTR-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-CEL-72163", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163", "REACTOME:R-SPO-72163", "REACTOME:R-XTR-72163" ]

9

[ "3jb9", "5gm6", "5gmk", "5lj3", "5lj5", "5mps", "5mq0", "5mqf", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "6bk8", "6exn", "6ff4", "6ff7", "6icz", "6id0", "6id1", "6j6g", "6j6h", "6j6n", "6j6q", "6qdv", "6zym", "7aav", "7abf", "7abg"...

60

[ "PUB00008533" ]

[ "11884590" ]

[ "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4666 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 1, 1, 2, 1, 3, 3, 1, 1, 12 ]

12

true

Family

Pre-mRNA-splicing factor Cwf15/Cwc15

Cwf_Cwc_15

6

IPR006974

6,974

Protein of unknown function DUF648

DUF648

Family

84

false

This is a family of hypothetical proteins from Chlamydia pneumoniae.

[]

0

[ "PFAM" ]

[ "PF04890" ]

[ "DUF648" ]

[ 84 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 84 ]

1

[]

0

true

Family

Protein of unknown function DUF648

DUF648

8

IPR006975

6,975

NifQ

Family

1,389

false

NifQ is involved in early stages of the biosynthesis of the iron-molybdenum cofactor (FeMo-co) [ ], which is an integral part of the active site of dinitrogenase [ ]. The conserved C-terminal cysteine residues may be involved in metal binding [ ].

[ "GO:0030151", "GO:0009399" ]

[ "molybdenum ion binding", "nitrogen fixation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04891" ]

[ "NifQ" ]

[ 1389 ]

1

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[]

0

[ "PUB00008693", "PUB00008694" ]

[ "8316214", "7954845" ]

[ "Structure of the nifQ gene from Enterobacter agglomerans 333 and its overexpression in Escherichia coli.", "Biosynthesis of the iron-molybdenum cofactor of nitrogenase." ]

[ 1993, 1994 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1375, 14 ]

2

[]

0

true

Family

NifQ

6

IPR006977

6,977

Yip1 domain

Yip1_dom

Domain

25,482

false

This entry contains proteins belonging to the Yip1 family and represents the Yip1 domain. The Yip1 integral membrane domain contains four transmembrane α-helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a Golgi protein involved in vesicular transport that interacts with GTPases [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04893" ]

[ "Yip1" ]

[ 25482 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-432722", "R-HSA-432722", "R-MMU-432722", "R-RNO-432722", "R-XTR-432722" ]

[ "REACTOME:R-BTA-432722", "REACTOME:R-HSA-432722", "REACTOME:R-MMU-432722", "REACTOME:R-RNO-432722", "REACTOME:R-XTR-432722" ]

5

[]

0

[ "PUB00020577" ]

[ "9724632" ]

[ "Specific binding to a novel and essential Golgi membrane protein (Yip1p) functionally links the transport GTPases Ypt1p and Ypt31p." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 903, 9749, 14679, 151 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 30, 11, 9, 5, 1, 16, 9, 3, 13, 24, 2, 3, 32 ]

13

true

Domain

Yip1 domain

Yip1_dom

2

IPR006978

6,978

Archaeal Nre, N-terminal

Nre_N

Domain

1,077

false

This conserved region is found in the N-terminal region of archaeal Nre proteins. While most archaeal organisms encode only a single Nre protein, some encode two, NreA and NreB.

[]

0

[ "PFAM" ]

[ "PF04894" ]

[ "Nre_N" ]

[ 1077 ]

1

[]

0

[]

0

[ "PUB00077939" ]

[ "26337406" ]

[ "A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Candidatus Staskawiczbacteria bacterium RIFCSPHIGHO2_01_FULL_41_41", "ecological metagenomes" ]

[ 1023, 1, 53 ]

3

[]

0

true

Domain

Archaeal Nre, N-terminal

Nre_N

5

IPR006979

6,979

Archaeal Nre, C-terminal

Nre_C

Domain

1,057

false

This conserved region is found in the C-terminal region of archaeal Nre proteins. While most archaeal organisms encode only a single Nre protein, some encode two, NreA and NreB.

[]

0

[ "PFAM" ]

[ "PF04895" ]

[ "Nre_C" ]

[ 1057 ]

1

[]

0

[]

0

[ "PUB00077939" ]

[ "26337406" ]

[ "A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Candidatus Staskawiczbacteria bacterium RIFCSPHIGHO2_01_FULL_41_41", "ecological metagenomes" ]

[ 1015, 1, 41 ]

3

[]

0

true

Domain

Archaeal Nre, C-terminal

Nre_C

2

IPR006980

6,980

Ammonia monooxygenase/particulate methane monooxygenase, subunit C

NH3_CH4_mOase_C

Family

457

false

Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [ ]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04896", "TIGR03078" ]

[ "AmoC", "CH4_NH3mon_ox_C" ]

[ 457, 266 ]

2

[ "GP" ]

[ "GenProp0666" ]

[ "GP:GenProp0666" ]

1

[ "1yew", "3chx", "3rfr", "3rgb", "4phz", "4pi0", "4pi2", "6cxh", "7ev9", "7s4h", "7s4i", "7s4j", "7s4k", "7s4l", "7s4m", "7t4o", "7t4p", "7yzy", "8oyi", "8sqw", "8sr1", "8sr2", "8sr4", "8sr5", "9cl1", "9cl2", "9cl3", "9cl4", "9cl5", "9cl6" ]

30

[ "PUB00016963", "PUB00016964", "PUB00016965" ]

[ "7590173", "12209257", "15674245" ]

[ "Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.", "Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.", "Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane." ]

[ 1995, 2002, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 79, 345, 33 ]

3

[]

0

true

Family

Ammonia monooxygenase/particulate methane monooxygenase, subunit C

NH3_CH4_mOase_C

8

IPR006982

6,982

Glutamate synthase, central-N

Glu_synth_centr_N

Domain

28,018

false

The central domain of glutamate synthase connects the N-terminal amidotransferase domain with the FMN-binding domain and has an α/β overall topology [ ]. Glutamate synthase (GltS)1 is a key enzyme in the early stages of the assimilation of ammonia in bacteria, yeasts, and plants. In bacteria, L-glutamate is involved in...

[ "GO:0015930" ]

[ "glutamate synthase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04898" ]

[ "Glu_syn_central" ]

[ 28018 ]

1

[]

0

[ "1ea0", "1llw", "1llz", "1lm1", "1ofd", "1ofe", "2vdc", "6s6s", "6s6t", "6s6u", "6s6x", "7mfm", "7mft" ]

13

[ "PUB00008698", "PUB00009386" ]

[ "11967268", "10357231" ]

[ "Structural studies on the synchronization of catalytic centers in glutamate synthase.", "Glutamate synthase: a complex iron-sulfur flavoprotein." ]

[ 2002, 1999 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 402, 21607, 5568, 441 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosacchar...

[ 13, 2, 3, 1, 1, 8, 1, 1, 85 ]

9

true

Domain

Glutamate synthase, central-N

Glu_synth_centr_N

9

IPR006983

6,983

MbeD/MobD-like

MbeD_MobD

Family

768

false

The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmid mobilisation and transfer in the presence of conjugative plasmids [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF033829", "PF04899" ]

[ "plas_excl_MbeD", "MbeD_MobD" ]

[ 534, 768 ]

2

[]

0

[]

0

[ "PUB00008700", "PUB00105357" ]

[ "2671664", "7592368" ]

[ "Characterization of the ColE1 mobilization region and its protein products.", "A ColE1-encoded gene directs entry exclusion of the plasmid." ]

[ 1989, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 730, 32, 3, 3 ]

4

[]

0

true

Family

MbeD/MobD-like

MbeD_MobD

3

IPR006984

6,984

Fcf1/UTP23

Family

8,985

false

Utp23 share homology with PINc domain protein Fcf1. They are components of the small subunit processome (SSU) that are involved in rRNA-processing and ribosome biogenesis [ , ].

[ "GO:0032040" ]

[ "small-subunit processome" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04900" ]

[ "Fcf1" ]

[ 8985 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-DDI-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-DDI-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

7

[ "4mj7", "5jpq", "5oql", "5wlc", "5wyj", "5wyk", "5yz4", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6nd4", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqg", "7ajt", "7aju", "7d4i", "7d5s"...

57

[ "PUB00035397", "PUB00067997" ]

[ "16762320", "16769905" ]

[ "Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.", "The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation." ]

[ 2006, 2006 ]

2

[]

0

null

[ "Eukaryota", "Marine Group III euryarchaeote", "marine metagenome" ]

[ 8983, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 4, 4, 8, 5, 2, 4, 9, 2, 2, 23 ]

12

true

Family

Fcf1/UTP23

8

IPR006985

6,985

Receptor activity modifying protein

RAMP

Family

3,162

false

The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor activity modifying protein (RAMP). RAMPs are single-transmembrane-domain proteins [ ].

[ "GO:0015026", "GO:0006886", "GO:0008277", "GO:0016020" ]

[ "coreceptor activity", "intracellular protein transport", "regulation of G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF04901", "PTHR14076" ]

[ "RAMP", "" ]

[ 3143, 3128 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418555", "R-HSA-419812", "R-HSA-9856530", "R-MMU-418555", "R-MMU-419812", "R-MMU-9856530", "R-RNO-419812", "R-RNO-9856530", "R-SSC-418555", "R-SSC-419812" ]

[ "REACTOME:R-HSA-418555", "REACTOME:R-HSA-419812", "REACTOME:R-HSA-9856530", "REACTOME:R-MMU-418555", "REACTOME:R-MMU-419812", "REACTOME:R-MMU-9856530", "REACTOME:R-RNO-419812", "REACTOME:R-RNO-9856530", "REACTOME:R-SSC-418555", "REACTOME:R-SSC-419812" ]

10

[ "2xvt", "2yx8", "3aqe", "3aqf", "3n7p", "3n7r", "3n7s", "4rwf", "4rwg", "5v6y", "6d1u", "6e3y", "6umg", "6uun", "6uus", "6uva", "6v2e", "6zho", "6zis", "7knt", "7knu", "7p0f", "7p0i", "7tyf", "7tyh", "7tyw", "7tyx", "7tyy", "7tzf", "8ax5", "8ax6", "8ax7"...

41

[ "PUB00008701" ]

[ "9620797" ]

[ "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor." ]

[ 1998 ]

1

[]

0

null

[ "Chordata", "bird metagenome" ]

[ 3161, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 11, 8, 23 ]

4

true

Family

Receptor activity modifying protein

RAMP

6

IPR006986

6,986

Nab1, C-terminal

Nab1_C

Domain

1,130

false

Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors [ ]. This C-terminal region is found only in the Nab1 subfamily.

[ "GO:0003712", "GO:0006355", "GO:0005634" ]

[ "transcription coregulator activity", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04902" ]

[ "Nab1" ]

[ 1130 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9031628", "R-HSA-9619665" ]

[ "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-9619665" ]

2

[]

0

[ "PUB00008702" ]

[ "9418898" ]

[ "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain." ]

[ 1998 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 1130 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 5, 4, 4 ]

4

true

Domain

Nab1, C-terminal

Nab1_C

4